Reaction Diagram
Physiology
| Universal ID's | Text Annotations |
|---|---|
|
|
|
| Reaction |
Name
Structure
|
Kinetics | Depiction |
|---|---|---|---|
| PP1nuc_D34nucPP1nuc+D34nuc |
PP1nuc_D34nuc_off
nucleus
|
MassAction | PP1nuc_D34nucPP1nuc+D34nuc |
|
|
|
reaction rate (J): ((Kf * PP1nuc_D34nuc) - ((Kr * PP1nuc) * D34nuc))[uM.s-1]
forward rate constant (Kf): PP1_D34_koff[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1] |
|
| D3497cyto_PP2BcytoD3497cyto+PP2Bcyto |
D3497cyto_PP2Bcyto_off
cytosol
|
MassAction | D3497cyto_PP2BcytoD3497cyto+PP2Bcyto |
|
|
|
reaction rate (J): ((Kf * D3497cyto_PP2Bcyto) - ((Kr * D3497cyto) * PP2Bcyto))[uM.s-1]
forward rate constant (Kf): D34_PP2B_koff[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1] |
|
| PP1nuc_D3497nucPP1nuc+D3497nuc |
PP1nuc_D3497nuc_off
nucleus
|
MassAction | PP1nuc_D3497nucPP1nuc+D3497nuc |
|
|
|
reaction rate (J): ((Kf * PP1nuc_D3497nuc) - ((Kr * PP1nuc) * D3497nuc))[uM.s-1]
forward rate constant (Kf): PP1_D34_koff[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1] |
|
| PP1cyto_D34cyto_PP2BcytoPP1nuc_D34nuc_PP2Bnuc |
PP1cyto_D34cyto_PP2Bcyto_cyto2nuc
nucleusmembrane
|
MassAction | PP1cyto_D34cyto_PP2BcytoPP1nuc_D34nuc_PP2Bnuc |
|
|
|
reaction rate (J): ((Kf * PP1cyto_D34cyto_PP2Bcyto) - (Kr * PP1nuc_D34nuc_PP2Bnuc))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kDcyto2nuc[molecules.um-2.s-1.uM-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-1] |
|
| PP2ApcytoPP2Apnuc |
PP2Apcyto2nuc
nucleusmembrane
|
MassAction | PP2ApcytoPP2Apnuc |
|
|
|
reaction rate (J): ((Kf * PP2Apcyto) - (Kr * PP2Apnuc))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): 0.0[molecules.um-2.s-1.uM-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-1] |
|
| D97cyto_PKAcytoPKAcyto+D97cyto |
D97cyto_PKAcyto_off
cytosol
|
MassAction | D97cyto_PKAcytoPKAcyto+D97cyto |
|
|
|
reaction rate (J): ((Kf * D97cyto_PKAcyto) - ((Kr * PKAcyto) * D97cyto))[uM.s-1]
forward rate constant (Kf): D_PKA_koff[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1] |
|
| PP1cyto_D3497cyto_PP2BcytoPP1nuc_D3497nuc_PP2Bnuc |
PP1cyto_D3497cyto_PP2Bcyto_cyto2nuc
nucleusmembrane
|
MassAction | PP1cyto_D3497cyto_PP2BcytoPP1nuc_D3497nuc_PP2Bnuc |
|
|
|
reaction rate (J): ((Kf * PP1cyto_D3497cyto_PP2Bcyto) - (Kr * PP1nuc_D3497nuc_PP2Bnuc))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kDcyto2nuc[molecules.um-2.s-1.uM-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-1] |
|
| D97cyto_PP2ApcytoPP2Apcyto+D97cyto |
D97cyto_PP2Apcyto_off
cytosol
|
MassAction | D97cyto_PP2ApcytoPP2Apcyto+D97cyto |
|
|
|
reaction rate (J): ((Kf * D97cyto_PP2Apcyto) - ((Kr * PP2Apcyto) * D97cyto))[uM.s-1]
forward rate constant (Kf): D97_PP2Ap_koff[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1] |
|
| D97nucD97cyto |
D97nuc2cyto
nucleusmembrane
|
MassAction | D97nucD97cyto |
|
|
|
reaction rate (J): ((Kf * D97nuc) - (Kr * D97cyto))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kD97nuc2cyto[molecules.um-2.s-1.uM-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-1] |
|
| D3497cyto+PP2ApcytoD3497cyto_PP2Apcyto |
D3497cyto_PP2Apcyto_on
cytosol
|
MassAction | D3497cyto+PP2ApcytoD3497cyto_PP2Apcyto |
|
|
|
reaction rate (J): (((Kf * D3497cyto) * PP2Apcyto) - (Kr * D3497cyto_PP2Apcyto))[uM.s-1]
forward rate constant (Kf): D97_PP2Ap_kon[s-1.uM-1] reverse rate constant (Kr): 0.0[s-1] |
|
| DcytoDnuc |
Dcyto2nuc_passive
nucleusmembrane
|
MassAction | DcytoDnuc |
|
|
|
reaction rate (J): ((Kf * Dcyto) - (Kr * Dnuc))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kDcyto2nuc_passive[molecules.um-2.s-1.uM-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-1] |
|
| D34cytoD34nuc |
D34cyto2nuc_passive
nucleusmembrane
|
MassAction | D34cytoD34nuc |
|
|
|
reaction rate (J): ((Kf * D34cyto) - (Kr * D34nuc))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kDcyto2nuc_passive[molecules.um-2.s-1.uM-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-1] |
|
| PP2Bcyto+D3497cytoD3497cyto_PP2Bcyto |
D3497cyto_PP2Bcyto_on
cytosol
|
MassAction | PP2Bcyto+D3497cytoD3497cyto_PP2Bcyto |
|
|
|
reaction rate (J): (((Kf * PP2Bcyto) * D3497cyto) - (Kr * D3497cyto_PP2Bcyto))[uM.s-1]
forward rate constant (Kf): D34_PP2B_kon[s-1.uM-1] reverse rate constant (Kr): 0.0[s-1] |
|
| PP1nuc_D34nucPP1cyto_D34cyto |
PP1nuc_D34nuc_nuc2cyto
nucleusmembrane
|
MassAction | PP1nuc_D34nucPP1cyto_D34cyto |
|
|
|
reaction rate (J): ((Kf * PP1nuc_D34nuc) - (Kr * PP1cyto_D34cyto))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): 0.0[molecules.um-2.s-1.uM-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-1] |
|
| Dnuc_CK2D97nuc+CK2 |
Dnuc_CK2_cat
nucleus
|
MassAction | Dnuc_CK2D97nuc+CK2 |
|
|
|
reaction rate (J): ((Kf * Dnuc_CK2) - ((Kr * D97nuc) * CK2))[uM.s-1]
forward rate constant (Kf): D_CK2_kcat[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1] |
|
| D3497nucD3497cyto |
D3497nuc2cyto
nucleusmembrane
|
MassAction | D3497nucD3497cyto |
|
|
|
reaction rate (J): ((Kf * D3497nuc) - (Kr * D3497cyto))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kD97nuc2cyto[molecules.um-2.s-1.uM-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-1] |
|
| D97nuc_PKAnucD3497nuc+PKAnuc |
D97nuc_PKAnuc_cat
nucleus
|
MassAction | D97nuc_PKAnucD3497nuc+PKAnuc |
|
|
|
reaction rate (J): ((Kf * D97nuc_PKAnuc) - ((Kr * D3497nuc) * PKAnuc))[uM.s-1]
forward rate constant (Kf): D_PKA_kcat[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1] |
|
| PP2Anuc_PKAnucPP2Apnuc+PKAnuc |
PP2Anuc_PKAnuc_cat
nucleus
|
MassAction | PP2Anuc_PKAnucPP2Apnuc+PKAnuc |
|
|
|
reaction rate (J): ((Kf * PP2Anuc_PKAnuc) - ((Kr * PP2Apnuc) * PKAnuc))[uM.s-1]
forward rate constant (Kf): PP2A_PKA_kcat[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1] |
|
| D97nuc_PP2ApnucPP2Apnuc+Dnuc |
D97nuc_PP2Apnuc_cat
nucleus
|
MassAction | D97nuc_PP2ApnucPP2Apnuc+Dnuc |
|
|
|
reaction rate (J): ((Kf * D97nuc_PP2Apnuc) - ((Kr * PP2Apnuc) * Dnuc))[uM.s-1]
forward rate constant (Kf): D97_PP2Ap_kcat[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1] |
|
| PP1nuc_D3497nuc_PP2BnucPP2Bnuc+PP1nuc+D97nuc |
PP1nuc_D3497nuc_PP2Bnuc_cat
nucleus
|
MassAction | PP1nuc_D3497nuc_PP2BnucPP2Bnuc+PP1nuc+D97nuc |
|
|
|
reaction rate (J): ((Kf * PP1nuc_D3497nuc_PP2Bnuc) - (((Kr * PP2Bnuc) * PP1nuc) * D97nuc))[uM.s-1]
forward rate constant (Kf): D34_PP2B_kcat[s-1] reverse rate constant (Kr): 0.0[s-1.uM-2] |
|
| PP1nuc_D3497nuc_PP2BnucPP1nuc_D3497nuc+PP2Bnuc |
PP1nuc_D3497nuc_PP2Bnuc_off
nucleus
|
MassAction | PP1nuc_D3497nuc_PP2BnucPP1nuc_D3497nuc+PP2Bnuc |
|
|
|
reaction rate (J): ((Kf * PP1nuc_D3497nuc_PP2Bnuc) - ((Kr * PP1nuc_D3497nuc) * PP2Bnuc))[uM.s-1]
forward rate constant (Kf): D34_PP2B_koff[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1] |
|
| PP1cyto_D34cyto_PP2BcytoDcyto+PP2Bcyto+PP1cyto |
PP1cyto_D34cyto_PP2Bcyto_cat
cytosol
|
MassAction | PP1cyto_D34cyto_PP2BcytoDcyto+PP2Bcyto+PP1cyto |
|
|
|
reaction rate (J): ((Kf * PP1cyto_D34cyto_PP2Bcyto) - (((Kr * Dcyto) * PP2Bcyto) * PP1cyto))[uM.s-1]
forward rate constant (Kf): D34_PP2B_kcat[s-1] reverse rate constant (Kr): 0.0[s-1.uM-2] |
|
| D3497cytoD3497nuc |
D3497cyto2nuc
nucleusmembrane
|
MassAction | D3497cytoD3497nuc |
|
|
|
reaction rate (J): ((Kf * D3497cyto) - (Kr * D3497nuc))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kDcyto2nuc[molecules.um-2.s-1.uM-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-1] |
|
| D3497nucD3497cyto |
D3497nuc2cyto_passive
nucleusmembrane
|
MassAction | D3497nucD3497cyto |
|
|
|
reaction rate (J): ((Kf * D3497nuc) - (Kr * D3497cyto))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kDnuc2cyto_passive[molecules.um-2.s-1.uM-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-1] |
|
| D3497nuc+PP2BnucD3497nuc_PP2Bnuc |
D3497nuc_PP2Bnuc_on
nucleus
|
MassAction | D3497nuc+PP2BnucD3497nuc_PP2Bnuc |
|
|
|
reaction rate (J): (((Kf * D3497nuc) * PP2Bnuc) - (Kr * D3497nuc_PP2Bnuc))[uM.s-1]
forward rate constant (Kf): D34_PP2B_kon[s-1.uM-1] reverse rate constant (Kr): 0.0[s-1] |
|
| PP2AnucPP2Acyto |
PP2Anuc2cyto
nucleusmembrane
|
MassAction | PP2AnucPP2Acyto |
|
|
|
reaction rate (J): ((Kf * PP2Anuc) - (Kr * PP2Acyto))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): 0.0[molecules.um-2.s-1.uM-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-1] |
|
| PP2Acyto_PKAcytoPKAcyto+PP2Apcyto |
PP2Acyto_PKAcyto_cat
cytosol
|
MassAction | PP2Acyto_PKAcytoPKAcyto+PP2Apcyto |
|
|
|
reaction rate (J): ((Kf * PP2Acyto_PKAcyto) - ((Kr * PKAcyto) * PP2Apcyto))[uM.s-1]
forward rate constant (Kf): PP2A_PKA_kcat[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1] |
|
| PP2Acyto_PKAcytoPKAcyto+PP2Acyto |
PP2Acyto_PKAcyto_off
cytosol
|
MassAction | PP2Acyto_PKAcytoPKAcyto+PP2Acyto |
|
|
|
reaction rate (J): ((Kf * PP2Acyto_PKAcyto) - ((Kr * PKAcyto) * PP2Acyto))[uM.s-1]
forward rate constant (Kf): PP2A_PKA_koff[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1] |
|
| D34nuc_CK2CK2+D3497nuc |
D34nuc_CK2_cat
nucleus
|
MassAction | D34nuc_CK2CK2+D3497nuc |
|
|
|
reaction rate (J): ((Kf * D34nuc_CK2) - ((Kr * CK2) * D3497nuc))[uM.s-1]
forward rate constant (Kf): D_CK2_kcat[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1] |
|
| DnucDcyto |
Dnuc2cyto_passive
nucleusmembrane
|
MassAction | DnucDcyto |
|
|
|
reaction rate (J): ((Kf * Dnuc) - (Kr * Dcyto))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kDnuc2cyto_passive[molecules.um-2.s-1.uM-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-1] |
|
| Dnuc_CK2Dnuc+CK2 |
Dnuc_CK2_off
nucleus
|
MassAction | Dnuc_CK2Dnuc+CK2 |
|
|
|
reaction rate (J): ((Kf * Dnuc_CK2) - ((Kr * Dnuc) * CK2))[uM.s-1]
forward rate constant (Kf): D_CK2_koff[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1] |
|
| DMNB_cAMPcAMP |
photoUncaging_DMNB_cAMP
cytosol
|
GeneralKinetics | DMNB_cAMPcAMP |
|
|
|
reaction rate (J): (kphoto * light * DMNB_cAMP)[uM.s-1]
user defined (light): (((t > ton_global) * (t < toff_global)) + ((t > ton_local) * (t < toff_local) * light_spot))[tbd] user defined (kphoto): 0.1[tbd] user defined (ton_global): 0.0[tbd] user defined (toff_global): 0.0[tbd] user defined (ton_local): 0.0[tbd] user defined (toff_local): 0.0[tbd] |
|
| Dcyto+PKAcytoDcyto_PKAcyto |
Dcyto_PKAcyto_on
cytosol
|
MassAction | Dcyto+PKAcytoDcyto_PKAcyto |
|
|
|
reaction rate (J): (((Kf * Dcyto) * PKAcyto) - (Kr * Dcyto_PKAcyto))[uM.s-1]
forward rate constant (Kf): D_PKA_kon[s-1.uM-1] reverse rate constant (Kr): 0.0[s-1] |
|
| Dnuc_PKAnucD34nuc+PKAnuc |
Dnuc_PKAnuc_cat
nucleus
|
MassAction | Dnuc_PKAnucD34nuc+PKAnuc |
|
|
|
reaction rate (J): ((Kf * Dnuc_PKAnuc) - ((Kr * D34nuc) * PKAnuc))[uM.s-1]
forward rate constant (Kf): D_PKA_kcat[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1] |
|
| D97nuc+PKAnucD97nuc_PKAnuc |
D97nuc_PKAnuc_on
nucleus
|
MassAction | D97nuc+PKAnucD97nuc_PKAnuc |
|
|
|
reaction rate (J): (((Kf * D97nuc) * PKAnuc) - (Kr * D97nuc_PKAnuc))[uM.s-1]
forward rate constant (Kf): D_PKA_kon[s-1.uM-1] reverse rate constant (Kr): 0.0[s-1] |
|
| D3497cyto_PP2BcytoD3497nuc_PP2Bnuc |
D3497cyto_PP2Bcyto_cyto2nuc
nucleusmembrane
|
MassAction | D3497cyto_PP2BcytoD3497nuc_PP2Bnuc |
|
|
|
reaction rate (J): ((Kf * D3497cyto_PP2Bcyto) - (Kr * D3497nuc_PP2Bnuc))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kDcyto2nuc[molecules.um-2.s-1.uM-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-1] |
|
| PP2Bcyto+PP1cyto_D34cytoPP1cyto_D34cyto_PP2Bcyto |
PP1cyto_D34cyto_PP2Bcyto_on
cytosol
|
MassAction | PP2Bcyto+PP1cyto_D34cytoPP1cyto_D34cyto_PP2Bcyto |
|
|
|
reaction rate (J): (((Kf * PP2Bcyto) * PP1cyto_D34cyto) - (Kr * PP1cyto_D34cyto_PP2Bcyto))[uM.s-1]
forward rate constant (Kf): D34_PP2B_kon[s-1.uM-1] reverse rate constant (Kr): 0.0[s-1] |
|
| D34nuc+PP2BnucD34nuc_PP2Bnuc |
D34nuc_PP2Bnuc_on
nucleus
|
MassAction | D34nuc+PP2BnucD34nuc_PP2Bnuc |
|
|
|
reaction rate (J): (((Kf * D34nuc) * PP2Bnuc) - (Kr * D34nuc_PP2Bnuc))[uM.s-1]
forward rate constant (Kf): D34_PP2B_kon[s-1.uM-1] reverse rate constant (Kr): 0.0[s-1] |
|
| R2+PKAcytoR2C |
R2_PKAcyto_bind
cytosol
|
MassAction | R2+PKAcytoR2C |
|
|
|
reaction rate (J): (((Kf * R2) * PKAcyto) - (Kr * R2C))[uM.s-1]
forward rate constant (Kf): 18.0[s-1.uM-1] reverse rate constant (Kr): 0.0[s-1] |
|
| Dcyto_PKAcytoPKAcyto+Dcyto |
Dcyto_PKAcyto_off
cytosol
|
MassAction | Dcyto_PKAcytoPKAcyto+Dcyto |
|
|
|
reaction rate (J): ((Kf * Dcyto_PKAcyto) - ((Kr * PKAcyto) * Dcyto))[uM.s-1]
forward rate constant (Kf): D_PKA_koff[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1] |
|
| D3497cyto_PP2ApcytoD34cyto+PP2Apcyto |
D3497cyto_PP2Apcyto_cat
cytosol
|
MassAction | D3497cyto_PP2ApcytoD34cyto+PP2Apcyto |
|
|
|
reaction rate (J): ((Kf * D3497cyto_PP2Apcyto) - ((Kr * D34cyto) * PP2Apcyto))[uM.s-1]
forward rate constant (Kf): D97_PP2Ap_kcat[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1] |
|
| PP2Anuc+PKAnucPP2Anuc_PKAnuc |
PP2Anuc_PKAnuc_on
nucleus
|
MassAction | PP2Anuc+PKAnucPP2Anuc_PKAnuc |
|
|
|
reaction rate (J): (((Kf * PP2Anuc) * PKAnuc) - (Kr * PP2Anuc_PKAnuc))[uM.s-1]
forward rate constant (Kf): PP2A_PKA_kon[s-1.uM-1] reverse rate constant (Kr): 0.0[s-1] |
|
| PP2BnucPP2Bcyto |
PP2Bnuc2cyto
nucleusmembrane
|
MassAction | PP2BnucPP2Bcyto |
|
|
|
reaction rate (J): ((Kf * PP2Bnuc) - (Kr * PP2Bcyto))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): 0.0[molecules.um-2.s-1.uM-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-1] |
|
| PP2Acyto+PKAcytoPP2Acyto_PKAcyto |
PP2Acyto_PKAcyto_on
cytosol
|
MassAction | PP2Acyto+PKAcytoPP2Acyto_PKAcyto |
|
|
|
reaction rate (J): (((Kf * PP2Acyto) * PKAcyto) - (Kr * PP2Acyto_PKAcyto))[uM.s-1]
forward rate constant (Kf): PP2A_PKA_kon[s-1.uM-1] reverse rate constant (Kr): 0.0[s-1] |
|
| PP2Bnuc+PP1nuc_D3497nucPP1nuc_D3497nuc_PP2Bnuc |
PP1nuc_D3497nuc_PP2Bnuc_on
nucleus
|
MassAction | PP2Bnuc+PP1nuc_D3497nucPP1nuc_D3497nuc_PP2Bnuc |
|
|
|
reaction rate (J): (((Kf * PP2Bnuc) * PP1nuc_D3497nuc) - (Kr * PP1nuc_D3497nuc_PP2Bnuc))[uM.s-1]
forward rate constant (Kf): D34_PP2B_kon[s-1.uM-1] reverse rate constant (Kr): 0.0[s-1] |
|
| R2C+PKAcytoR2C2 |
R2C_PKAcyto_bind
cytosol
|
MassAction | R2C+PKAcytoR2C2 |
|
|
|
reaction rate (J): (((Kf * R2C) * PKAcyto) - (Kr * R2C2))[uM.s-1]
forward rate constant (Kf): 18.0[s-1.uM-1] reverse rate constant (Kr): 0.0[s-1] |
|
| PP1cyto_D3497cytoPP1cyto+D3497cyto |
PP1cyto_D3497_off
cytosol
|
MassAction | PP1cyto_D3497cytoPP1cyto+D3497cyto |
|
|
|
reaction rate (J): ((Kf * PP1cyto_D3497cyto) - ((Kr * PP1cyto) * D3497cyto))[uM.s-1]
forward rate constant (Kf): PP1_D34_koff[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1] |
|
| D3497cyto_PP2BcytoD97cyto+PP2Bcyto |
D3497cyto_PP2Bcyto_cat
cytosol
|
MassAction | D3497cyto_PP2BcytoD97cyto+PP2Bcyto |
|
|
|
reaction rate (J): ((Kf * D3497cyto_PP2Bcyto) - ((Kr * D97cyto) * PP2Bcyto))[uM.s-1]
forward rate constant (Kf): D34_PP2B_kcat[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1] |
|
| PP1nuc_D34nuc_PP2BnucPP1nuc+Dnuc+PP2Bnuc |
PP1nuc_D34nuc_PP2Bnuc_cat
nucleus
|
MassAction | PP1nuc_D34nuc_PP2BnucPP1nuc+Dnuc+PP2Bnuc |
|
|
|
reaction rate (J): ((Kf * PP1nuc_D34nuc_PP2Bnuc) - (((Kr * PP1nuc) * Dnuc) * PP2Bnuc))[uM.s-1]
forward rate constant (Kf): D34_PP2B_kcat[s-1] reverse rate constant (Kr): 0.0[s-1.uM-2] |
|
| D34nuc+PP1nucPP1nuc_D34nuc |
PP1nuc_D34nuc_on
nucleus
|
MassAction | D34nuc+PP1nucPP1nuc_D34nuc |
|
|
|
reaction rate (J): (((Kf * D34nuc) * PP1nuc) - (Kr * PP1nuc_D34nuc))[uM.s-1]
forward rate constant (Kf): PP1_D34_kon[s-1.uM-1] reverse rate constant (Kr): 0.0[s-1] |
|
| Dcyto_PKAcytoPKAcyto+D34cyto |
Dcyto_PKAcyto_cat
cytosol
|
MassAction | Dcyto_PKAcytoPKAcyto+D34cyto |
|
|
|
reaction rate (J): ((Kf * Dcyto_PKAcyto) - ((Kr * PKAcyto) * D34cyto))[uM.s-1]
forward rate constant (Kf): D_PKA_kcat[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1] |
|
| PP1cyto_D34cyto_PP2BcytoPP2Bcyto+PP1cyto_D34cyto |
PP1cyto_D34cyto_PP2Bcyto_off
cytosol
|
MassAction | PP1cyto_D34cyto_PP2BcytoPP2Bcyto+PP1cyto_D34cyto |
|
|
|
reaction rate (J): ((Kf * PP1cyto_D34cyto_PP2Bcyto) - ((Kr * PP2Bcyto) * PP1cyto_D34cyto))[uM.s-1]
forward rate constant (Kf): D34_PP2B_koff[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1] |
|
| D97cyto_PP2ApcytoD97nuc_PP2Apnuc |
D97cyto_PP2Apcyto_cyto2nuc
nucleusmembrane
|
MassAction | D97cyto_PP2ApcytoD97nuc_PP2Apnuc |
|
|
|
reaction rate (J): ((Kf * D97cyto_PP2Apcyto) - (Kr * D97nuc_PP2Apnuc))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kDcyto2nuc[molecules.um-2.s-1.uM-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-1] |
|
| Dnuc+CK2Dnuc_CK2 |
Dnuc_CK2_on
nucleus
|
MassAction | Dnuc+CK2Dnuc_CK2 |
|
|
|
reaction rate (J): (((Kf * Dnuc) * CK2) - (Kr * Dnuc_CK2))[uM.s-1]
forward rate constant (Kf): D_CK2_kon[s-1.uM-1] reverse rate constant (Kr): 0.0[s-1] |
|
| PP1cyto_D34cytoPP1nuc_D34nuc |
PP1cyto_D34cyto_cyto2nuc
nucleusmembrane
|
MassAction | PP1cyto_D34cytoPP1nuc_D34nuc |
|
|
|
reaction rate (J): ((Kf * PP1cyto_D34cyto) - (Kr * PP1nuc_D34nuc))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kDcyto2nuc[molecules.um-2.s-1.uM-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-1] |
|
| D3497nuc_PP2BnucD3497cyto_PP2Bcyto |
D3497nuc_PP2Bnuc_nuc2cyto
nucleusmembrane
|
MassAction | D3497nuc_PP2BnucD3497cyto_PP2Bcyto |
|
|
|
reaction rate (J): ((Kf * D3497nuc_PP2Bnuc) - (Kr * D3497cyto_PP2Bcyto))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kD97nuc2cyto[molecules.um-2.s-1.uM-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-1] |
|
| D3497nuc_PP2ApnucD34nuc+PP2Apnuc |
D3497nuc_PP2Apnuc_cat
nucleus
|
MassAction | D3497nuc_PP2ApnucD34nuc+PP2Apnuc |
|
|
|
reaction rate (J): ((Kf * D3497nuc_PP2Apnuc) - ((Kr * D34nuc) * PP2Apnuc))[uM.s-1]
forward rate constant (Kf): D97_PP2Ap_kcat[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1] |
|
| D34nuc_PP2BnucPP2Bnuc+Dnuc |
D34nuc_PP2Bnuc_cat
nucleus
|
MassAction | D34nuc_PP2BnucPP2Bnuc+Dnuc |
|
|
|
reaction rate (J): ((Kf * D34nuc_PP2Bnuc) - ((Kr * PP2Bnuc) * Dnuc))[uM.s-1]
forward rate constant (Kf): D34_PP2B_kcat[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1] |
|
| DcytoDnuc |
Dcyto2nuc
nucleusmembrane
|
MassAction | DcytoDnuc |
|
|
|
reaction rate (J): ((Kf * Dcyto) - (Kr * Dnuc))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kDcyto2nuc[molecules.um-2.s-1.uM-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-1] |
|
| cAMPsourcecAMP+cAMPsource |
cAMPsource2cAMP
cytosol
|
MassAction | cAMPsourcecAMP+cAMPsource |
|
|
|
reaction rate (J): ((Kf * cAMPsource) - ((Kr * cAMP) * cAMPsource))[uM.s-1]
forward rate constant (Kf): 0.1[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1] |
|
| D97nuc_PKAnucD97cyto_PKAcyto |
D97nuc_PKAnuc_nuc2cyto
nucleusmembrane
|
MassAction | D97nuc_PKAnucD97cyto_PKAcyto |
|
|
|
reaction rate (J): ((Kf * D97nuc_PKAnuc) - (Kr * D97cyto_PKAcyto))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kD97nuc2cyto[molecules.um-2.s-1.uM-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-1] |
|
| cAMP_PDE10AAMP+PDE10A |
cAMP_PDE10A_cat
cytosol
|
MassAction | cAMP_PDE10AAMP+PDE10A |
|
|
|
reaction rate (J): ((Kf * cAMP_PDE10A) - ((Kr * AMP) * PDE10A))[uM.s-1]
forward rate constant (Kf): cAMP_PDE10A_kcat[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1] |
|
| PP1cyto_D34cytoPP1cyto+D34cyto |
PP1cyto_D34cyto_off
cytosol
|
MassAction | PP1cyto_D34cytoPP1cyto+D34cyto |
|
|
|
reaction rate (J): ((Kf * PP1cyto_D34cyto) - ((Kr * PP1cyto) * D34cyto))[uM.s-1]
forward rate constant (Kf): PP1_D34_koff[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1] |
|
| PKAnucPKAcyto |
PKAnuc2cyto
nucleusmembrane
|
MassAction | PKAnucPKAcyto |
|
|
|
reaction rate (J): ((Kf * PKAnuc) - (Kr * PKAcyto))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kPKAnuc2cyto_passive[molecules.um-2.s-1.uM-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-1] |
|
| D3497nuc+PP2ApnucD3497nuc_PP2Apnuc |
D3497nuc_PP2Apnuc_on
nucleus
|
MassAction | D3497nuc+PP2ApnucD3497nuc_PP2Apnuc |
|
|
|
reaction rate (J): (((Kf * D3497nuc) * PP2Apnuc) - (Kr * D3497nuc_PP2Apnuc))[uM.s-1]
forward rate constant (Kf): D97_PP2Ap_kon[s-1.uM-1] reverse rate constant (Kr): 0.0[s-1] |
|
| PKAnuc+DnucDnuc_PKAnuc |
Dnuc_PKAnuc_on
nucleus
|
MassAction | PKAnuc+DnucDnuc_PKAnuc |
|
|
|
reaction rate (J): (((Kf * PKAnuc) * Dnuc) - (Kr * Dnuc_PKAnuc))[uM.s-1]
forward rate constant (Kf): D_PKA_kon[s-1.uM-1] reverse rate constant (Kr): 0.0[s-1] |
|
| D34cyto_PP2BcytoD34cyto+PP2Bcyto |
D34cyto_PP2Bcyto_off
cytosol
|
MassAction | D34cyto_PP2BcytoD34cyto+PP2Bcyto |
|
|
|
reaction rate (J): ((Kf * D34cyto_PP2Bcyto) - ((Kr * D34cyto) * PP2Bcyto))[uM.s-1]
forward rate constant (Kf): D34_PP2B_koff[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1] |
|
| D3497cyto_PP2ApcytoPP2Apcyto+D3497cyto |
D3497cyto_PP2Apcyto_off
cytosol
|
MassAction | D3497cyto_PP2ApcytoPP2Apcyto+D3497cyto |
|
|
|
reaction rate (J): ((Kf * D3497cyto_PP2Apcyto) - ((Kr * PP2Apcyto) * D3497cyto))[uM.s-1]
forward rate constant (Kf): D97_PP2Ap_koff[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1] |
|
| PP1cytoPP1nuc |
PP1cyto2nuc
nucleusmembrane
|
MassAction | PP1cytoPP1nuc |
|
|
|
reaction rate (J): ((Kf * PP1cyto) - (Kr * PP1nuc))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): 0.0[molecules.um-2.s-1.uM-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-1] |
|
| D34nuc_CK2CK2+D34nuc |
D34nuc_CK2_off
nucleus
|
MassAction | D34nuc_CK2CK2+D34nuc |
|
|
|
reaction rate (J): ((Kf * D34nuc_CK2) - ((Kr * CK2) * D34nuc))[uM.s-1]
forward rate constant (Kf): D_CK2_koff[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1] |
|
| PP1nuc_D34nuc_PP2BnucPP1nuc_D34nuc+PP2Bnuc |
PP1nuc_D34nuc_PP2Bnuc_off
nucleus
|
MassAction | PP1nuc_D34nuc_PP2BnucPP1nuc_D34nuc+PP2Bnuc |
|
|
|
reaction rate (J): ((Kf * PP1nuc_D34nuc_PP2Bnuc) - ((Kr * PP1nuc_D34nuc) * PP2Bnuc))[uM.s-1]
forward rate constant (Kf): D34_PP2B_koff[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1] |
|
| PP1nuc_D3497nuc_PP2BnucPP1cyto_D3497cyto_PP2Bcyto |
PP1nuc_D3497nuc_PP2Bnuc_nuc2cyto
nucleusmembrane
|
MassAction | PP1nuc_D3497nuc_PP2BnucPP1cyto_D3497cyto_PP2Bcyto |
|
|
|
reaction rate (J): ((Kf * PP1nuc_D3497nuc_PP2Bnuc) - (Kr * PP1cyto_D3497cyto_PP2Bcyto))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kD97nuc2cyto[molecules.um-2.s-1.uM-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-1] |
|
| D97cyto+PP2ApcytoD97cyto_PP2Apcyto |
D97cyto_PP2Apcyto_on
cytosol
|
MassAction | D97cyto+PP2ApcytoD97cyto_PP2Apcyto |
|
|
|
reaction rate (J): (((Kf * D97cyto) * PP2Apcyto) - (Kr * D97cyto_PP2Apcyto))[uM.s-1]
forward rate constant (Kf): D97_PP2Ap_kon[s-1.uM-1] reverse rate constant (Kr): 0.0[s-1] |
|
| cAMP4_R2cAMP+cAMP+cAMP+R2+cAMP |
cAMP4_R2_releasecAMP
cytosol
|
MassAction | cAMP4_R2cAMP+cAMP+cAMP+R2+cAMP |
|
|
|
reaction rate (J): ((Kf * cAMP4_R2) - (((((Kr * cAMP) * cAMP) * cAMP) * R2) * cAMP))[uM.s-1]
forward rate constant (Kf): 0.0012[s-1] reverse rate constant (Kr): 0.0[s-1.uM-4] |
|
| PP2Anuc_PKAnucPP2Acyto_PKAcyto |
PP2Anuc_PKAnuc_nuc2cyto
nucleusmembrane
|
MassAction | PP2Anuc_PKAnucPP2Acyto_PKAcyto |
|
|
|
reaction rate (J): ((Kf * PP2Anuc_PKAnuc) - (Kr * PP2Acyto_PKAcyto))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): 0.0[molecules.um-2.s-1.uM-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-1] |
|
| D34nuc_PP2BnucPP2Bnuc+D34nuc |
D34nuc_PP2Bnuc_off
nucleus
|
MassAction | D34nuc_PP2BnucPP2Bnuc+D34nuc |
|
|
|
reaction rate (J): ((Kf * D34nuc_PP2Bnuc) - ((Kr * PP2Bnuc) * D34nuc))[uM.s-1]
forward rate constant (Kf): D34_PP2B_koff[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1] |
|
| D97cyto_PP2ApcytoDcyto+PP2Apcyto |
D97cyto_PP2Apcyto_cat
cytosol
|
MassAction | D97cyto_PP2ApcytoDcyto+PP2Apcyto |
|
|
|
reaction rate (J): ((Kf * D97cyto_PP2Apcyto) - ((Kr * Dcyto) * PP2Apcyto))[uM.s-1]
forward rate constant (Kf): D97_PP2Ap_kcat[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1] |
|
| PP1cyto_D3497cyto_PP2BcytoPP1cyto+D97cyto+PP2Bcyto |
PP1cyto_D3497cyto_PP2Bcyto_cat
cytosol
|
MassAction | PP1cyto_D3497cyto_PP2BcytoPP1cyto+D97cyto+PP2Bcyto |
|
|
|
reaction rate (J): ((Kf * PP1cyto_D3497cyto_PP2Bcyto) - (((Kr * PP1cyto) * D97cyto) * PP2Bcyto))[uM.s-1]
forward rate constant (Kf): D34_PP2B_kcat[s-1] reverse rate constant (Kr): 0.0[s-1.uM-2] |
|
| cAMP+R2C2cAMP_R2C2 |
cAMP_R2C2_onoff
cytosol
|
MassAction | cAMP+R2C2cAMP_R2C2 |
|
|
|
reaction rate (J): (((Kf * cAMP) * R2C2) - (Kr * cAMP_R2C2))[uM.s-1]
forward rate constant (Kf): cAMP_R2C2_kon[s-1.uM-1] reverse rate constant (Kr): cAMP_R2C2_koff[s-1] |
|
| D3497nuc_PP2BnucPP2Bnuc+D97nuc |
D3497nuc_PP2Bnuc_cat
nucleus
|
MassAction | D3497nuc_PP2BnucPP2Bnuc+D97nuc |
|
|
|
reaction rate (J): ((Kf * D3497nuc_PP2Bnuc) - ((Kr * PP2Bnuc) * D97nuc))[uM.s-1]
forward rate constant (Kf): D34_PP2B_kcat[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1] |
|
| D34nuc+CK2D34nuc_CK2 |
D34nuc_CK2_on
nucleus
|
MassAction | D34nuc+CK2D34nuc_CK2 |
|
|
|
reaction rate (J): (((Kf * D34nuc) * CK2) - (Kr * D34nuc_CK2))[uM.s-1]
forward rate constant (Kf): D_CK2_kon[s-1.uM-1] reverse rate constant (Kr): 0.0[s-1] |
|
| D97nuc_PP2ApnucPP2Apnuc+D97nuc |
D97nuc_PP2Apnuc_off
nucleus
|
MassAction | D97nuc_PP2ApnucPP2Apnuc+D97nuc |
|
|
|
reaction rate (J): ((Kf * D97nuc_PP2Apnuc) - ((Kr * PP2Apnuc) * D97nuc))[uM.s-1]
forward rate constant (Kf): D97_PP2Ap_koff[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1] |
|
| D34cyto_PP2BcytoD34nuc_PP2Bnuc |
D34cyto_PP2Bcyto_cyto2nuc
nucleusmembrane
|
MassAction | D34cyto_PP2BcytoD34nuc_PP2Bnuc |
|
|
|
reaction rate (J): ((Kf * D34cyto_PP2Bcyto) - (Kr * D34nuc_PP2Bnuc))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kDcyto2nuc[molecules.um-2.s-1.uM-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-1] |
|
| cAMP4_R2C2cAMP4_R2C+PKAcyto |
cAMP4_R2C_PKA_onoff
cytosol
|
MassAction | cAMP4_R2C2cAMP4_R2C+PKAcyto |
|
|
|
reaction rate (J): ((Kf * cAMP4_R2C2) - ((Kr * cAMP4_R2C) * PKAcyto))[uM.s-1]
forward rate constant (Kf): cAMP4R2C_PKA_koff[s-1] reverse rate constant (Kr): cAMP4R2C_PKA_kon[s-1.uM-1] |
|
| cAMP+cAMP2_R2C2cAMP3_R2C2 |
cAMP_cAMP2_R2C2_onoff
cytosol
|
MassAction | cAMP+cAMP2_R2C2cAMP3_R2C2 |
|
|
|
reaction rate (J): (((Kf * cAMP) * cAMP2_R2C2) - (Kr * cAMP3_R2C2))[uM.s-1]
forward rate constant (Kf): cAMP_cAMP2R2C2_kon[s-1.uM-1] reverse rate constant (Kr): cAMP_cAMP2R2C2_koff[s-1] |
|
| cAMP4_R2CcAMP4_R2+PKAcyto |
cAMP4_R2_PKA_onoff
cytosol
|
MassAction | cAMP4_R2CcAMP4_R2+PKAcyto |
|
|
|
reaction rate (J): ((Kf * cAMP4_R2C) - ((Kr * cAMP4_R2) * PKAcyto))[uM.s-1]
forward rate constant (Kf): cAMP4R2_PKA_koff[s-1] reverse rate constant (Kr): cAMP4R2_PKA_kon[s-1.uM-1] |
|
| D97nucD97cyto |
D97nuc2cyto_passive
nucleusmembrane
|
MassAction | D97nucD97cyto |
|
|
|
reaction rate (J): ((Kf * D97nuc) - (Kr * D97cyto))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kDnuc2cyto_passive[molecules.um-2.s-1.uM-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-1] |
|
| Dcyto_PKAcytoDnuc_PKAnuc |
Dcyto_PKAcyto_cyto2nuc
nucleusmembrane
|
MassAction | Dcyto_PKAcytoDnuc_PKAnuc |
|
|
|
reaction rate (J): ((Kf * Dcyto_PKAcyto) - (Kr * Dnuc_PKAnuc))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kDcyto2nuc[molecules.um-2.s-1.uM-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-1] |
|
| PP2ApnucPP2Apcyto |
PP2Apnuc2cyto
nucleusmembrane
|
MassAction | PP2ApnucPP2Apcyto |
|
|
|
reaction rate (J): ((Kf * PP2Apnuc) - (Kr * PP2Apcyto))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): 0.0[molecules.um-2.s-1.uM-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-1] |
|
| PP2Anuc_PKAnucPP2Anuc+PKAnuc |
PP2Anuc_PKANuc_off
nucleus
|
MassAction | PP2Anuc_PKAnucPP2Anuc+PKAnuc |
|
|
|
reaction rate (J): ((Kf * PP2Anuc_PKAnuc) - ((Kr * PP2Anuc) * PKAnuc))[uM.s-1]
forward rate constant (Kf): PP2A_PKA_koff[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1] |
|
| PKAcytoPKAnuc |
PKAcyto2nuc
nucleusmembrane
|
MassAction | PKAcytoPKAnuc |
|
|
|
reaction rate (J): ((Kf * PKAcyto) - (Kr * PKAnuc))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kPKAcyto2nuc_passive[molecules.um-2.s-1.uM-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-1] |
|
| PP2Acyto_PKAcytoPP2Anuc_PKAnuc |
PP2Acyto_PKAcyto_cyto2nuc
nucleusmembrane
|
MassAction | PP2Acyto_PKAcytoPP2Anuc_PKAnuc |
|
|
|
reaction rate (J): ((Kf * PP2Acyto_PKAcyto) - (Kr * PP2Anuc_PKAnuc))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): 0.0[molecules.um-2.s-1.uM-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-1] |
|
| D3497cyto+PP1cytoPP1cyto_D3497cyto |
PP1cyto_D3497cyto_on
cytosol
|
MassAction | D3497cyto+PP1cytoPP1cyto_D3497cyto |
|
|
|
reaction rate (J): (((Kf * D3497cyto) * PP1cyto) - (Kr * PP1cyto_D3497cyto))[uM.s-1]
forward rate constant (Kf): PP1_D34_kon[s-1.uM-1] reverse rate constant (Kr): 0.0[s-1] |
|
| D97nuc_PP2ApnucD97cyto_PP2Apcyto |
D97nuc_PP2Apnuc_nuc2cyto
nucleusmembrane
|
MassAction | D97nuc_PP2ApnucD97cyto_PP2Apcyto |
|
|
|
reaction rate (J): ((Kf * D97nuc_PP2Apnuc) - (Kr * D97cyto_PP2Apcyto))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kD97nuc2cyto[molecules.um-2.s-1.uM-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-1] |
|
| PP2ApcytoPP2Acyto |
PP2Apcytodephosphorylation
cytosol
|
MassAction | PP2ApcytoPP2Acyto |
|
|
|
reaction rate (J): ((Kf * PP2Apcyto) - (Kr * PP2Acyto))[uM.s-1]
forward rate constant (Kf): 0.1[s-1] reverse rate constant (Kr): 0.0[s-1] |
|
| PP2BcytoPP2Bnuc |
PP2Bcyto2nuc
nucleusmembrane
|
MassAction | PP2BcytoPP2Bnuc |
|
|
|
reaction rate (J): ((Kf * PP2Bcyto) - (Kr * PP2Bnuc))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): 0.0[molecules.um-2.s-1.uM-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-1] |
|
| PP1cyto_D3497cyto+PP2BcytoPP1cyto_D3497cyto_PP2Bcyto |
PP1cyto_D3497cyto_PP2Bcyto_on
cytosol
|
MassAction | PP1cyto_D3497cyto+PP2BcytoPP1cyto_D3497cyto_PP2Bcyto |
|
|
|
reaction rate (J): (((Kf * PP1cyto_D3497cyto) * PP2Bcyto) - (Kr * PP1cyto_D3497cyto_PP2Bcyto))[uM.s-1]
forward rate constant (Kf): D34_PP2B_kon[s-1.uM-1] reverse rate constant (Kr): 0.0[s-1] |
|
| PP1nuc_D34nuc+PP2BnucPP1nuc_D34nuc_PP2Bnuc |
PP1nuc_D34nuc_PP2Bnuc_on
nucleus
|
MassAction | PP1nuc_D34nuc+PP2BnucPP1nuc_D34nuc_PP2Bnuc |
|
|
|
reaction rate (J): (((Kf * PP1nuc_D34nuc) * PP2Bnuc) - (Kr * PP1nuc_D34nuc_PP2Bnuc))[uM.s-1]
forward rate constant (Kf): D34_PP2B_kon[s-1.uM-1] reverse rate constant (Kr): 0.0[s-1] |
|
| PP2Apnuc+D97nucD97nuc_PP2Apnuc |
D97nuc_PP2Apnuc_on
nucleus
|
MassAction | PP2Apnuc+D97nucD97nuc_PP2Apnuc |
|
|
|
reaction rate (J): (((Kf * PP2Apnuc) * D97nuc) - (Kr * D97nuc_PP2Apnuc))[uM.s-1]
forward rate constant (Kf): D97_PP2Ap_kon[s-1.uM-1] reverse rate constant (Kr): 0.0[s-1] |
|
| D34cytoD34nuc |
D34cyto2nuc
nucleusmembrane
|
MassAction | D34cytoD34nuc |
|
|
|
reaction rate (J): ((Kf * D34cyto) - (Kr * D34nuc))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kDcyto2nuc[molecules.um-2.s-1.uM-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-1] |
|
| PP2AcytoPP2Anuc |
PP2Acyto2nuc
nucleusmembrane
|
MassAction | PP2AcytoPP2Anuc |
|
|
|
reaction rate (J): ((Kf * PP2Acyto) - (Kr * PP2Anuc))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): 0.0[molecules.um-2.s-1.uM-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-1] |
|
| PP1cyto_D3497cyto_PP2BcytoPP1cyto_D3497cyto+PP2Bcyto |
PP1cyto_D3497cyto_PP2Bcyto_off
cytosol
|
MassAction | PP1cyto_D3497cyto_PP2BcytoPP1cyto_D3497cyto+PP2Bcyto |
|
|
|
reaction rate (J): ((Kf * PP1cyto_D3497cyto_PP2Bcyto) - ((Kr * PP1cyto_D3497cyto) * PP2Bcyto))[uM.s-1]
forward rate constant (Kf): D34_PP2B_koff[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1] |
|
| PP1nucPP1cyto |
PP1nuc2cyto
nucleusmembrane
|
MassAction | PP1nucPP1cyto |
|
|
|
reaction rate (J): ((Kf * PP1nuc) - (Kr * PP1cyto))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): 0.0[molecules.um-2.s-1.uM-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-1] |
|
| D97cytoD97nuc |
D97cyto2nuc_passive
nucleusmembrane
|
MassAction | D97cytoD97nuc |
|
|
|
reaction rate (J): ((Kf * D97cyto) - (Kr * D97nuc))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kDcyto2nuc_passive[molecules.um-2.s-1.uM-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-1] |
|
| cAMP+cAMP_R2C2cAMP2_R2C2 |
cAMP_cAMP_R2C2_onoff
cytosol
|
MassAction | cAMP+cAMP_R2C2cAMP2_R2C2 |
|
|
|
reaction rate (J): (((Kf * cAMP) * cAMP_R2C2) - (Kr * cAMP2_R2C2))[uM.s-1]
forward rate constant (Kf): cAMP_cAMPR2C2_kon[s-1.uM-1] reverse rate constant (Kr): cAMP_cAMPR2C2_koff[s-1] |
|
| PP1cyto_D3497cytoPP1nuc_D3497nuc |
PP1cyto_D3497cyto_cyto2nuc
nucleusmembrane
|
MassAction | PP1cyto_D3497cytoPP1nuc_D3497nuc |
|
|
|
reaction rate (J): ((Kf * PP1cyto_D3497cyto) - (Kr * PP1nuc_D3497nuc))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kDcyto2nuc[molecules.um-2.s-1.uM-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-1] |
|
| PP1nuc_D3497nucPP1cyto_D3497cyto |
PP1nuc_D3497nuc_nuc2cyto
nucleusmembrane
|
MassAction | PP1nuc_D3497nucPP1cyto_D3497cyto |
|
|
|
reaction rate (J): ((Kf * PP1nuc_D3497nuc) - (Kr * PP1cyto_D3497cyto))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kD97nuc2cyto[molecules.um-2.s-1.uM-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-1] |
|
| D34cyto_PP2BcytoDcyto+PP2Bcyto |
D34cyto_PP2Bcyto_cat
cytosol
|
MassAction | D34cyto_PP2BcytoDcyto+PP2Bcyto |
|
|
|
reaction rate (J): ((Kf * D34cyto_PP2Bcyto) - ((Kr * Dcyto) * PP2Bcyto))[uM.s-1]
forward rate constant (Kf): D34_PP2B_kcat[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1] |
|
| D34cyto+PP2BcytoD34cyto_PP2Bcyto |
D34cyto_PP2Bcyto_on
cytosol
|
MassAction | D34cyto+PP2BcytoD34cyto_PP2Bcyto |
|
|
|
reaction rate (J): (((Kf * D34cyto) * PP2Bcyto) - (Kr * D34cyto_PP2Bcyto))[uM.s-1]
forward rate constant (Kf): D34_PP2B_kon[s-1.uM-1] reverse rate constant (Kr): 0.0[s-1] |
|
| D3497nuc_PP2BnucD3497nuc+PP2Bnuc |
D3497nuc_PP2Bnuc_off
nucleus
|
MassAction | D3497nuc_PP2BnucD3497nuc+PP2Bnuc |
|
|
|
reaction rate (J): ((Kf * D3497nuc_PP2Bnuc) - ((Kr * D3497nuc) * PP2Bnuc))[uM.s-1]
forward rate constant (Kf): D34_PP2B_koff[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1] |
|
| D3497cytoD3497nuc |
D3497cyto2nuc_passive
nucleusmembrane
|
MassAction | D3497cytoD3497nuc |
|
|
|
reaction rate (J): ((Kf * D3497cyto) - (Kr * D3497nuc))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kDcyto2nuc_passive[molecules.um-2.s-1.uM-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-1] |
|
| D34nucD34cyto |
D34nuc2cyto_passive
nucleusmembrane
|
MassAction | D34nucD34cyto |
|
|
|
reaction rate (J): ((Kf * D34nuc) - (Kr * D34cyto))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kDnuc2cyto_passive[molecules.um-2.s-1.uM-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-1] |
|
| D97cyto_PKAcytoD97nuc_PKAnuc |
D97cyto_PKAcyto_cyto2nuc
nucleusmembrane
|
MassAction | D97cyto_PKAcytoD97nuc_PKAnuc |
|
|
|
reaction rate (J): ((Kf * D97cyto_PKAcyto) - (Kr * D97nuc_PKAnuc))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kDcyto2nuc[molecules.um-2.s-1.uM-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-1] |
|
| D3497nuc_PP2ApnucPP2Apnuc+D3497nuc |
D3497nuc_PP2Apnuc_off
nucleus
|
MassAction | D3497nuc_PP2ApnucPP2Apnuc+D3497nuc |
|
|
|
reaction rate (J): ((Kf * D3497nuc_PP2Apnuc) - ((Kr * PP2Apnuc) * D3497nuc))[uM.s-1]
forward rate constant (Kf): D97_PP2Ap_koff[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1] |
|
| PP2ApnucPP2Anuc |
PP2Apnucdephosphorylation
nucleus
|
MassAction | PP2ApnucPP2Anuc |
|
|
|
reaction rate (J): ((Kf * PP2Apnuc) - (Kr * PP2Anuc))[uM.s-1]
forward rate constant (Kf): 0.1[s-1] reverse rate constant (Kr): 0.0[s-1] |
|
| D3497nuc+PP1nucPP1nuc_D3497nuc |
PP1nuc_D3497nuc_on
nucleus
|
MassAction | D3497nuc+PP1nucPP1nuc_D3497nuc |
|
|
|
reaction rate (J): (((Kf * D3497nuc) * PP1nuc) - (Kr * PP1nuc_D3497nuc))[uM.s-1]
forward rate constant (Kf): PP1_D34_kon[s-1.uM-1] reverse rate constant (Kr): 0.0[s-1] |
|
| D97cyto+PKAcytoD97cyto_PKAcyto |
D97cyto_PKAcyto_on
cytosol
|
MassAction | D97cyto+PKAcytoD97cyto_PKAcyto |
|
|
|
reaction rate (J): (((Kf * D97cyto) * PKAcyto) - (Kr * D97cyto_PKAcyto))[uM.s-1]
forward rate constant (Kf): D_PKA_kon[s-1.uM-1] reverse rate constant (Kr): 0.0[s-1] |
|
| PP1cyto+D34cytoPP1cyto_D34cyto |
PP1cyto_D34cyto_on
cytosol
|
MassAction | PP1cyto+D34cytoPP1cyto_D34cyto |
|
|
|
reaction rate (J): (((Kf * PP1cyto) * D34cyto) - (Kr * PP1cyto_D34cyto))[uM.s-1]
forward rate constant (Kf): PP1_D34_kon[s-1.uM-1] reverse rate constant (Kr): 0.0[s-1] |
|
| D97cytoD97nuc |
D97cyto2nuc
nucleusmembrane
|
MassAction | D97cytoD97nuc |
|
|
|
reaction rate (J): ((Kf * D97cyto) - (Kr * D97nuc))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kDcyto2nuc[molecules.um-2.s-1.uM-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-1] |
|
| Dnuc_PKAnucPKAnuc+Dnuc |
Dnuc_PKAnuc_off
nucleus
|
MassAction | Dnuc_PKAnucPKAnuc+Dnuc |
|
|
|
reaction rate (J): ((Kf * Dnuc_PKAnuc) - ((Kr * PKAnuc) * Dnuc))[uM.s-1]
forward rate constant (Kf): D_PKA_koff[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1] |
|
| cAMP3_R2C2+cAMPcAMP4_R2C2 |
cAMP_cAMP3_R2C2_onoff
cytosol
|
MassAction | cAMP3_R2C2+cAMPcAMP4_R2C2 |
|
|
|
reaction rate (J): (((Kf * cAMP3_R2C2) * cAMP) - (Kr * cAMP4_R2C2))[uM.s-1]
forward rate constant (Kf): cAMP_cAMP3R2C2_kon[s-1.uM-1] reverse rate constant (Kr): cAMP_cAMP3R2C2_koff[s-1] |
|
| D3497cyto_PP2ApcytoD3497nuc_PP2Apnuc |
D3497cyto_PP2Apcyto_cyto2nuc
nucleusmembrane
|
MassAction | D3497cyto_PP2ApcytoD3497nuc_PP2Apnuc |
|
|
|
reaction rate (J): ((Kf * D3497cyto_PP2Apcyto) - (Kr * D3497nuc_PP2Apnuc))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kDcyto2nuc[molecules.um-2.s-1.uM-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-1] |
|
| D3497nuc_PP2ApnucD3497cyto_PP2Apcyto |
D3497nuc_PP2Apnuc_nuc2cyto
nucleusmembrane
|
MassAction | D3497nuc_PP2ApnucD3497cyto_PP2Apcyto |
|
|
|
reaction rate (J): ((Kf * D3497nuc_PP2Apnuc) - (Kr * D3497cyto_PP2Apcyto))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kD97nuc2cyto[molecules.um-2.s-1.uM-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-1] |
|
| D97cyto_PKAcytoD3497cyto+PKAcyto |
D97cyto_PKAcyto_cat
cytosol
|
MassAction | D97cyto_PKAcytoD3497cyto+PKAcyto |
|
|
|
reaction rate (J): ((Kf * D97cyto_PKAcyto) - ((Kr * D3497cyto) * PKAcyto))[uM.s-1]
forward rate constant (Kf): D_PKA_kcat[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1] |
|
| D97nuc_PKAnucD97nuc+PKAnuc |
D97nuc_PKAnuc_off
nucleus
|
MassAction | D97nuc_PKAnucD97nuc+PKAnuc |
|
|
|
reaction rate (J): ((Kf * D97nuc_PKAnuc) - ((Kr * D97nuc) * PKAnuc))[uM.s-1]
forward rate constant (Kf): D_PKA_koff[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1] |
|
| cAMP+PDE10AcAMP_PDE10A |
cAMP_PDE10A_onoff
cytosol
|
MassAction | cAMP+PDE10AcAMP_PDE10A |
|
|
|
reaction rate (J): (((Kf * cAMP) * PDE10A) - (Kr * cAMP_PDE10A))[uM.s-1]
forward rate constant (Kf): cAMP_PDE10A_kon[s-1.uM-1] reverse rate constant (Kr): cAMP_PDE10A_koff[s-1] |
| Name |
Type
Electrical (Membrane Polarity)
|
|---|---|
| c0 |
Compartment
(+) (-)
|
|
|
|
| cytosol |
Compartment
(+) (-)
|
|
|
|
| nucleus |
Compartment
(+) (-)
|
|
|
|
| cellmembrane |
Membrane
N/A
|
|
|
|
| nucleusmembrane |
Membrane
N/A
|
|
|
|
| Name | Structure | BioNetGen Definition |
|---|---|---|
| cAMPsource | cytosol | |
|
|
|
|
| D3497cyto | cytosol | |
|
|
|
|
| PP1cyto | cytosol | |
|
|
|
|
| PP1cyto_D34cyto | cytosol | |
|
|
|
|
| Dcyto | cytosol | |
|
|
|
|
| D97cyto_PP2Apcyto | cytosol | |
|
|
|
|
| R2 | cytosol | |
|
|
|
|
| PP2Bcyto | cytosol | |
|
|
|
|
| PP2Anuc | nucleus | |
|
|
|
|
| Dnuc_PKAnuc | nucleus | |
|
|
|
|
| D97nuc_PP2Apnuc | nucleus | |
|
|
|
|
| PP1cyto_D3497cyto_PP2Bcyto | cytosol | |
|
|
|
|
| PDE10A | cytosol | |
|
|
|
|
| cAMP_PDE10A | cytosol | |
|
|
|
|
| D97cyto_PKAcyto | cytosol | |
|
|
|
|
| PP1cyto_D34cyto_PP2Bcyto | cytosol | |
|
|
|
|
| AMP | cytosol | |
|
|
|
|
| PP1nuc_D34nuc_PP2Bnuc | nucleus | |
|
|
|
|
| cAMP | cytosol | |
|
|
|
|
| DMNB_cAMP | cytosol | |
|
|
|
|
| light_spot | cytosol | |
|
|
|
|
| R2C | cytosol | |
|
|
|
|
| D34nuc_CK2 | nucleus | |
|
|
|
|
| cAMP4_R2C2 | cytosol | |
|
|
|
|
| cAMP4_R2C | cytosol | |
|
|
|
|
| cAMP3_R2C2 | cytosol | |
|
|
|
|
| cAMP_R2C2 | cytosol | |
|
|
|
|
| cAMP2_R2C2 | cytosol | |
|
|
|
|
| D34cyto_PP2Bcyto | cytosol | |
|
|
|
|
| PKAcyto | cytosol | |
|
|
|
|
| D3497cyto_PP2Apcyto | cytosol | |
|
|
|
|
| Dcyto_PKAcyto | cytosol | |
|
|
|
|
| PP2Acyto_PKAcyto | cytosol | |
|
|
|
|
| Dnuc_CK2 | nucleus | |
|
|
|
|
| PP2Acyto | cytosol | |
|
|
|
|
| PP2Anuc_PKAnuc | nucleus | |
|
|
|
|
| Dnuc | nucleus | |
|
|
|
|
| cAMP4_R2 | cytosol | |
|
|
|
|
| D34nuc_PP2Bnuc | nucleus | |
|
|
|
|
| PP1nuc | nucleus | |
|
|
|
|
| PP1nuc_D34nuc | nucleus | |
|
|
|
|
| PP1nuc_D3497nuc | nucleus | |
|
|
|
|
| PP1nuc_D3497nuc_PP2Bnuc | nucleus | |
|
|
|
|
| D3497nuc_PP2Apnuc | nucleus | |
|
|
|
|
| D97nuc | nucleus | |
|
|
|
|
| D3497nuc_PP2Bnuc | nucleus | |
|
|
|
|
| CK2 | nucleus | |
|
|
|
|
| PP2Apcyto | cytosol | |
|
|
|
|
| PP2Apnuc | nucleus | |
|
|
|
|
| D97cyto | cytosol | |
|
|
|
|
| PP1cyto_D3497cyto | cytosol | |
|
|
|
|
| PP2Bnuc | nucleus | |
|
|
|
|
| D34cyto | cytosol | |
|
|
|
|
| D34nuc | nucleus | |
|
|
|
|
| D3497nuc | nucleus | |
|
|
|
|
| PKAnuc | nucleus | |
|
|
|
|
| D97nuc_PKAnuc | nucleus | |
|
|
|
|
| R2C2 | cytosol | |
|
|
|
|
| D3497cyto_PP2Bcyto | cytosol | |
|
|
|
| Name | Text Annotations | BioNetGen Definition |
|---|
| Name |
Type
Count
|
BioNetGen Definition |
|---|
Applications
| Name | Math Type | Annotation |
|---|---|---|
| cAMPinput_tertiary3 | Deterministic (ODE) Spatial (3D) | NA |
| cAMPinput_secondary3 | Deterministic (ODE) Spatial (3D) | NA |
| cAMPinput_primary3 | Deterministic (ODE) Spatial (3D) | NA |
| cAMPinput_primary1 | Deterministic (ODE) Spatial (3D) | NA |
| cAMPinput_primary2 | Deterministic (ODE) Spatial (3D) | NA |
| cAMPinput_secondary1 | Deterministic (ODE) Spatial (3D) | NA |
| cAMPinput_secondary2 | Deterministic (ODE) Spatial (3D) | NA |
| cAMPinput_tertiary1 | Deterministic (ODE) Spatial (3D) | NA |
| cAMPinput_tertiary2 | Deterministic (ODE) Spatial (3D) | NA |
Application - cAMPinput_tertiary3
| Species | Initial Condition | Diffusion Constant | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| cAMPsource | (200.0 * (t < 5.0) * (((x >= 150.0) && (x <= 151.8) && (y >= - 12.0) && (y <= - 10.5) && (z >= 5.0) && (z <= 6.0)) + ((x >= 152.0) && (x <= 152.5) && (y >= - 12.0) && (y <= - 10.5) && (z >= 5.0) && (z <= 5.5)))) [uM] | 0.0
[um2/s] | D3497cyto |
0.0
[uM]
|
D_d32
[um2/s] | PP1cyto |
5.0
[uM]
|
D_pp1
[um2/s] | PP1cyto_D34cyto |
0.0
[uM]
|
D_d32pp1
[um2/s] | Dcyto |
0.0
[uM]
|
D_d32
[um2/s] | D97cyto_PP2Apcyto |
0.0
[uM]
|
D_d32pp2a
[um2/s] | R2 |
0.0
[uM]
|
D_r2
[um2/s] | PP2Bcyto |
1.6
[uM]
|
D_pp2b
[um2/s] | PP1cyto_D3497cyto_PP2Bcyto |
0.0
[uM]
|
D_d32pp1pp2b
[um2/s] | PDE10A |
1.0
[uM]
|
D_pde10a
[um2/s] | cAMP_PDE10A |
0.0
[uM]
|
D_pde10a
[um2/s] | D97cyto_PKAcyto |
0.0
[uM]
|
D_d32pkac
[um2/s] | PP1cyto_D34cyto_PP2Bcyto |
0.0
[uM]
|
D_d32pp1pp2b
[um2/s] | AMP |
0.0
[uM]
|
0.0
[um2/s] | cAMP |
0.0
[uM]
|
100.0
[um2/s] | DMNB_cAMP |
0.0
[uM]
|
100.0
[um2/s] | light_spot |
0.0
[uM]
|
0.0
[um2/s] | R2C |
0.0
[uM]
|
D_r2c
[um2/s] | cAMP4_R2C2 |
0.0
[uM]
|
D_r2c2
[um2/s] | cAMP4_R2C |
0.0
[uM]
|
D_r2c
[um2/s] | cAMP3_R2C2 |
0.0
[uM]
|
D_r2c2
[um2/s] | cAMP_R2C2 |
0.0
[uM]
|
D_r2c2
[um2/s] | cAMP2_R2C2 |
0.0
[uM]
|
D_r2c2
[um2/s] | D34cyto_PP2Bcyto |
0.0
[uM]
|
D_d32pp2b
[um2/s] | PKAcyto |
0.0
[uM]
|
D_pkac
[um2/s] | D3497cyto_PP2Apcyto |
0.0
[uM]
|
D_d32pp2a
[um2/s] | Dcyto_PKAcyto |
0.0
[uM]
|
D_d32pkac
[um2/s] | PP2Acyto_PKAcyto |
0.0
[uM]
|
D_pp2apka
[um2/s] | PP2Acyto |
2.0
[uM]
|
D_pp2a
[um2/s] | cAMP4_R2 |
0.0
[uM]
|
D_r2
[um2/s] | PP2Apcyto |
0.0
[uM]
|
D_pp2a
[um2/s] | D97cyto |
50.0
[uM]
|
D_d32
[um2/s] | PP1cyto_D3497cyto |
0.0
[uM]
|
D_d32pp1
[um2/s] | D34cyto |
0.0
[uM]
|
D_d32
[um2/s] | R2C2 |
1.0
[uM]
|
D_r2c2
[um2/s] | D3497cyto_PP2Bcyto |
0.0
[uM]
|
D_d32pp2b
[um2/s] | PP2Anuc |
2.0
[uM]
|
D_pp2a
[um2/s] | Dnuc_PKAnuc |
0.0
[uM]
|
D_d32pkac
[um2/s] | D97nuc_PP2Apnuc |
0.0
[uM]
|
D_d32pp2a
[um2/s] | PP1nuc_D34nuc_PP2Bnuc |
0.0
[uM]
|
D_d32pp1pp2b
[um2/s] | D34nuc_CK2 |
0.0
[uM]
|
D_d32ck2
[um2/s] | Dnuc_CK2 |
0.0
[uM]
|
D_d32ck2
[um2/s] | PP2Anuc_PKAnuc |
0.0
[uM]
|
D_pp2apka
[um2/s] | Dnuc |
0.0
[uM]
|
D_d32
[um2/s] | D34nuc_PP2Bnuc |
0.0
[uM]
|
D_d32pp2b
[um2/s] | PP1nuc |
5.0
[uM]
|
D_pp1
[um2/s] | PP1nuc_D34nuc |
0.0
[uM]
|
D_d32pp1
[um2/s] | PP1nuc_D3497nuc |
0.0
[uM]
|
D_d32pp1
[um2/s] | PP1nuc_D3497nuc_PP2Bnuc |
0.0
[uM]
|
D_d32pp1pp2b
[um2/s] | D3497nuc_PP2Apnuc |
0.0
[uM]
|
D_d32pp2a
[um2/s] | D97nuc |
30.0
[uM]
|
D_d32
[um2/s] | D3497nuc_PP2Bnuc |
0.0
[uM]
|
D_d32pp2b
[um2/s] | CK2 |
1.0
[uM]
|
D_ck2
[um2/s] | PP2Apnuc |
0.0
[uM]
|
D_pp2a
[um2/s] | PP2Bnuc |
1.6
[uM]
|
D_pp2b
[um2/s] | D34nuc |
0.0
[uM]
|
D_d32
[um2/s] | D3497nuc |
0.0
[uM]
|
D_d32
[um2/s] | PKAnuc |
0.0
[uM]
|
D_pkac
[um2/s] | D97nuc_PKAnuc |
0.0
[uM]
|
D_d32pkac
[um2/s]
|
|
| Name | Reaction Mapping |
|---|---|
| PP1nuc_D34nuc_off | included |
| D3497cyto_PP2Bcyto_off | included |
| PP1nuc_D3497nuc_off | included |
| PP1cyto_D34cyto_PP2Bcyto_cyto2nuc | included |
| PP2Apcyto2nuc | included |
| D97cyto_PKAcyto_off | included |
| PP1cyto_D3497cyto_PP2Bcyto_cyto2nuc | included |
| D97cyto_PP2Apcyto_off | included |
| D97nuc2cyto | included |
| D3497cyto_PP2Apcyto_on | included |
| Dcyto2nuc_passive | included |
| D34cyto2nuc_passive | included |
| D3497cyto_PP2Bcyto_on | included |
| PP1nuc_D34nuc_nuc2cyto | included |
| Dnuc_CK2_cat | included |
| D3497nuc2cyto | included |
| D97nuc_PKAnuc_cat | included |
| PP2Anuc_PKAnuc_cat | included |
| D97nuc_PP2Apnuc_cat | included |
| PP1nuc_D3497nuc_PP2Bnuc_cat | included |
| PP1nuc_D3497nuc_PP2Bnuc_off | included |
| PP1cyto_D34cyto_PP2Bcyto_cat | included |
| D3497cyto2nuc | included |
| D3497nuc2cyto_passive | included |
| D3497nuc_PP2Bnuc_on | included |
| PP2Anuc2cyto | included |
| PP2Acyto_PKAcyto_cat | included |
| PP2Acyto_PKAcyto_off | included |
| D34nuc_CK2_cat | included |
| Dnuc2cyto_passive | included |
| Dnuc_CK2_off | included |
| photoUncaging_DMNB_cAMP | included |
| Dcyto_PKAcyto_on | included |
| Dnuc_PKAnuc_cat | included |
| D97nuc_PKAnuc_on | included |
| D3497cyto_PP2Bcyto_cyto2nuc | included |
| PP1cyto_D34cyto_PP2Bcyto_on | included |
| D34nuc_PP2Bnuc_on | included |
| R2_PKAcyto_bind | included |
| Dcyto_PKAcyto_off | included |
| D3497cyto_PP2Apcyto_cat | included |
| PP2Anuc_PKAnuc_on | included |
| PP2Bnuc2cyto | included |
| PP2Acyto_PKAcyto_on | included |
| PP1nuc_D3497nuc_PP2Bnuc_on | included |
| R2C_PKAcyto_bind | included |
| PP1cyto_D3497_off | included |
| D3497cyto_PP2Bcyto_cat | included |
| PP1nuc_D34nuc_PP2Bnuc_cat | included |
| PP1nuc_D34nuc_on | included |
| Dcyto_PKAcyto_cat | included |
| PP1cyto_D34cyto_PP2Bcyto_off | included |
| D97cyto_PP2Apcyto_cyto2nuc | included |
| Dnuc_CK2_on | included |
| PP1cyto_D34cyto_cyto2nuc | included |
| D3497nuc_PP2Bnuc_nuc2cyto | included |
| D3497nuc_PP2Apnuc_cat | included |
| D34nuc_PP2Bnuc_cat | included |
| Dcyto2nuc | included |
| cAMPsource2cAMP | included |
| D97nuc_PKAnuc_nuc2cyto | included |
| cAMP_PDE10A_cat | included |
| PP1cyto_D34cyto_off | included |
| PKAnuc2cyto | included |
| D3497nuc_PP2Apnuc_on | included |
| Dnuc_PKAnuc_on | included |
| D34cyto_PP2Bcyto_off | included |
| D3497cyto_PP2Apcyto_off | included |
| PP1cyto2nuc | included |
| D34nuc_CK2_off | included |
| PP1nuc_D34nuc_PP2Bnuc_off | included |
| PP1nuc_D3497nuc_PP2Bnuc_nuc2cyto | included |
| D97cyto_PP2Apcyto_on | included |
| cAMP4_R2_releasecAMP | included |
| PP2Anuc_PKAnuc_nuc2cyto | included |
| D34nuc_PP2Bnuc_off | included |
| D97cyto_PP2Apcyto_cat | included |
| PP1cyto_D3497cyto_PP2Bcyto_cat | included |
| cAMP_R2C2_onoff | included |
| D3497nuc_PP2Bnuc_cat | included |
| D34nuc_CK2_on | included |
| D97nuc_PP2Apnuc_off | included |
| D34cyto_PP2Bcyto_cyto2nuc | included |
| cAMP4_R2C_PKA_onoff | included |
| cAMP_cAMP2_R2C2_onoff | included |
| cAMP4_R2_PKA_onoff | included |
| D97nuc2cyto_passive | included |
| Dcyto_PKAcyto_cyto2nuc | included |
| PP2Apnuc2cyto | included |
| PP2Anuc_PKANuc_off | included |
| PKAcyto2nuc | included |
| PP2Acyto_PKAcyto_cyto2nuc | included |
| PP1cyto_D3497cyto_on | included |
| D97nuc_PP2Apnuc_nuc2cyto | included |
| PP2Apcytodephosphorylation | included |
| PP2Bcyto2nuc | included |
| PP1cyto_D3497cyto_PP2Bcyto_on | included |
| PP1nuc_D34nuc_PP2Bnuc_on | included |
| D97nuc_PP2Apnuc_on | included |
| D34cyto2nuc | included |
| PP2Acyto2nuc | included |
| PP1cyto_D3497cyto_PP2Bcyto_off | included |
| PP1nuc2cyto | included |
| D97cyto2nuc_passive | included |
| cAMP_cAMP_R2C2_onoff | included |
| PP1cyto_D3497cyto_cyto2nuc | included |
| PP1nuc_D3497nuc_nuc2cyto | included |
| D34cyto_PP2Bcyto_cat | included |
| D34cyto_PP2Bcyto_on | included |
| D3497nuc_PP2Bnuc_off | included |
| D3497cyto2nuc_passive | included |
| D34nuc2cyto_passive | included |
| D97cyto_PKAcyto_cyto2nuc | included |
| D3497nuc_PP2Apnuc_off | included |
| PP2Apnucdephosphorylation | included |
| PP1nuc_D3497nuc_on | included |
| D97cyto_PKAcyto_on | included |
| PP1cyto_D34cyto_on | included |
| D97cyto2nuc | included |
| Dnuc_PKAnuc_off | included |
| cAMP_cAMP3_R2C2_onoff | included |
| D3497cyto_PP2Apcyto_cyto2nuc | included |
| D3497nuc_PP2Apnuc_nuc2cyto | included |
| D97cyto_PKAcyto_cat | included |
| D97nuc_PKAnuc_off | included |
| cAMP_PDE10A_onoff | included |
| Name | End Time | Output Options |
|---|---|---|
| cAMPtertiaryEnd | 3600.0 [s] |
OutputTimeStep 5.0 |
| Dimension | Type | Subdomain | Adjacent Subvolumes | Size | Mapped Compartment |
|---|---|---|---|---|---|
| Volume | Analytical | subdomain2 | 301.60068965661543 [um3] | nucleus | |
| Volume | Analytical | subdomain1 | 1202.1930494498022 [um3] | cytosol | |
| Volume | Analytical | subdomain0 | 66696.20626089358 [um3] | c0 | |
| Surface | subdomain0_subdomain1_membrane | subdomain0 | subdomain1 | 1432.4688299433924 [um2] | cellmembrane | |
| Surface | subdomain1_subdomain2_membrane | subdomain1 | subdomain2 | 211.84616618489457 [um2] | nucleusmembrane |
Application - cAMPinput_secondary3
| Species | Initial Condition | Diffusion Constant | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| cAMPsource | (200.0 * (t < 5.0) * ((x >= 90.0) && (x <= 91.8) && (y >= - 11.5) && (y <= - 10.0) && (z >= 5.0) && (z <= 5.5))) [uM] | 0.0
[um2/s] | D3497cyto |
0.0
[uM]
|
D_d32
[um2/s] | PP1cyto |
5.0
[uM]
|
D_pp1
[um2/s] | PP1cyto_D34cyto |
0.0
[uM]
|
D_d32pp1
[um2/s] | Dcyto |
0.0
[uM]
|
D_d32
[um2/s] | D97cyto_PP2Apcyto |
0.0
[uM]
|
D_d32pp2a
[um2/s] | R2 |
0.0
[uM]
|
D_r2
[um2/s] | PP2Bcyto |
1.6
[uM]
|
D_pp2b
[um2/s] | PP1cyto_D3497cyto_PP2Bcyto |
0.0
[uM]
|
D_d32pp1pp2b
[um2/s] | PDE10A |
1.0
[uM]
|
D_pde10a
[um2/s] | cAMP_PDE10A |
0.0
[uM]
|
D_pde10a
[um2/s] | D97cyto_PKAcyto |
0.0
[uM]
|
D_d32pkac
[um2/s] | PP1cyto_D34cyto_PP2Bcyto |
0.0
[uM]
|
D_d32pp1pp2b
[um2/s] | AMP |
0.0
[uM]
|
0.0
[um2/s] | cAMP |
0.0
[uM]
|
100.0
[um2/s] | DMNB_cAMP |
0.0
[uM]
|
100.0
[um2/s] | light_spot |
0.0
[uM]
|
0.0
[um2/s] | R2C |
0.0
[uM]
|
D_r2c
[um2/s] | cAMP4_R2C2 |
0.0
[uM]
|
D_r2c2
[um2/s] | cAMP4_R2C |
0.0
[uM]
|
D_r2c
[um2/s] | cAMP3_R2C2 |
0.0
[uM]
|
D_r2c2
[um2/s] | cAMP_R2C2 |
0.0
[uM]
|
D_r2c2
[um2/s] | cAMP2_R2C2 |
0.0
[uM]
|
D_r2c2
[um2/s] | D34cyto_PP2Bcyto |
0.0
[uM]
|
D_d32pp2b
[um2/s] | PKAcyto |
0.0
[uM]
|
D_pkac
[um2/s] | D3497cyto_PP2Apcyto |
0.0
[uM]
|
D_d32pp2a
[um2/s] | Dcyto_PKAcyto |
0.0
[uM]
|
D_d32pkac
[um2/s] | PP2Acyto_PKAcyto |
0.0
[uM]
|
D_pp2apka
[um2/s] | PP2Acyto |
2.0
[uM]
|
D_pp2a
[um2/s] | cAMP4_R2 |
0.0
[uM]
|
D_r2
[um2/s] | PP2Apcyto |
0.0
[uM]
|
D_pp2a
[um2/s] | D97cyto |
50.0
[uM]
|
D_d32
[um2/s] | PP1cyto_D3497cyto |
0.0
[uM]
|
D_d32pp1
[um2/s] | D34cyto |
0.0
[uM]
|
D_d32
[um2/s] | R2C2 |
1.0
[uM]
|
D_r2c2
[um2/s] | D3497cyto_PP2Bcyto |
0.0
[uM]
|
D_d32pp2b
[um2/s] | PP2Anuc |
2.0
[uM]
|
D_pp2a
[um2/s] | Dnuc_PKAnuc |
0.0
[uM]
|
D_d32pkac
[um2/s] | D97nuc_PP2Apnuc |
0.0
[uM]
|
D_d32pp2a
[um2/s] | PP1nuc_D34nuc_PP2Bnuc |
0.0
[uM]
|
D_d32pp1pp2b
[um2/s] | D34nuc_CK2 |
0.0
[uM]
|
D_d32ck2
[um2/s] | Dnuc_CK2 |
0.0
[uM]
|
D_d32ck2
[um2/s] | PP2Anuc_PKAnuc |
0.0
[uM]
|
D_pp2apka
[um2/s] | Dnuc |
0.0
[uM]
|
D_d32
[um2/s] | D34nuc_PP2Bnuc |
0.0
[uM]
|
D_d32pp2b
[um2/s] | PP1nuc |
5.0
[uM]
|
D_pp1
[um2/s] | PP1nuc_D34nuc |
0.0
[uM]
|
D_d32pp1
[um2/s] | PP1nuc_D3497nuc |
0.0
[uM]
|
D_d32pp1
[um2/s] | PP1nuc_D3497nuc_PP2Bnuc |
0.0
[uM]
|
D_d32pp1pp2b
[um2/s] | D3497nuc_PP2Apnuc |
0.0
[uM]
|
D_d32pp2a
[um2/s] | D97nuc |
30.0
[uM]
|
D_d32
[um2/s] | D3497nuc_PP2Bnuc |
0.0
[uM]
|
D_d32pp2b
[um2/s] | CK2 |
1.0
[uM]
|
D_ck2
[um2/s] | PP2Apnuc |
0.0
[uM]
|
D_pp2a
[um2/s] | PP2Bnuc |
1.6
[uM]
|
D_pp2b
[um2/s] | D34nuc |
0.0
[uM]
|
D_d32
[um2/s] | D3497nuc |
0.0
[uM]
|
D_d32
[um2/s] | PKAnuc |
0.0
[uM]
|
D_pkac
[um2/s] | D97nuc_PKAnuc |
0.0
[uM]
|
D_d32pkac
[um2/s]
|
|
| Name | Reaction Mapping |
|---|---|
| PP1nuc_D34nuc_off | included |
| D3497cyto_PP2Bcyto_off | included |
| PP1nuc_D3497nuc_off | included |
| PP1cyto_D34cyto_PP2Bcyto_cyto2nuc | included |
| PP2Apcyto2nuc | included |
| D97cyto_PKAcyto_off | included |
| PP1cyto_D3497cyto_PP2Bcyto_cyto2nuc | included |
| D97cyto_PP2Apcyto_off | included |
| D97nuc2cyto | included |
| D3497cyto_PP2Apcyto_on | included |
| Dcyto2nuc_passive | included |
| D34cyto2nuc_passive | included |
| D3497cyto_PP2Bcyto_on | included |
| PP1nuc_D34nuc_nuc2cyto | included |
| Dnuc_CK2_cat | included |
| D3497nuc2cyto | included |
| D97nuc_PKAnuc_cat | included |
| PP2Anuc_PKAnuc_cat | included |
| D97nuc_PP2Apnuc_cat | included |
| PP1nuc_D3497nuc_PP2Bnuc_cat | included |
| PP1nuc_D3497nuc_PP2Bnuc_off | included |
| PP1cyto_D34cyto_PP2Bcyto_cat | included |
| D3497cyto2nuc | included |
| D3497nuc2cyto_passive | included |
| D3497nuc_PP2Bnuc_on | included |
| PP2Anuc2cyto | included |
| PP2Acyto_PKAcyto_cat | included |
| PP2Acyto_PKAcyto_off | included |
| D34nuc_CK2_cat | included |
| Dnuc2cyto_passive | included |
| Dnuc_CK2_off | included |
| photoUncaging_DMNB_cAMP | included |
| Dcyto_PKAcyto_on | included |
| Dnuc_PKAnuc_cat | included |
| D97nuc_PKAnuc_on | included |
| D3497cyto_PP2Bcyto_cyto2nuc | included |
| PP1cyto_D34cyto_PP2Bcyto_on | included |
| D34nuc_PP2Bnuc_on | included |
| R2_PKAcyto_bind | included |
| Dcyto_PKAcyto_off | included |
| D3497cyto_PP2Apcyto_cat | included |
| PP2Anuc_PKAnuc_on | included |
| PP2Bnuc2cyto | included |
| PP2Acyto_PKAcyto_on | included |
| PP1nuc_D3497nuc_PP2Bnuc_on | included |
| R2C_PKAcyto_bind | included |
| PP1cyto_D3497_off | included |
| D3497cyto_PP2Bcyto_cat | included |
| PP1nuc_D34nuc_PP2Bnuc_cat | included |
| PP1nuc_D34nuc_on | included |
| Dcyto_PKAcyto_cat | included |
| PP1cyto_D34cyto_PP2Bcyto_off | included |
| D97cyto_PP2Apcyto_cyto2nuc | included |
| Dnuc_CK2_on | included |
| PP1cyto_D34cyto_cyto2nuc | included |
| D3497nuc_PP2Bnuc_nuc2cyto | included |
| D3497nuc_PP2Apnuc_cat | included |
| D34nuc_PP2Bnuc_cat | included |
| Dcyto2nuc | included |
| cAMPsource2cAMP | included |
| D97nuc_PKAnuc_nuc2cyto | included |
| cAMP_PDE10A_cat | included |
| PP1cyto_D34cyto_off | included |
| PKAnuc2cyto | included |
| D3497nuc_PP2Apnuc_on | included |
| Dnuc_PKAnuc_on | included |
| D34cyto_PP2Bcyto_off | included |
| D3497cyto_PP2Apcyto_off | included |
| PP1cyto2nuc | included |
| D34nuc_CK2_off | included |
| PP1nuc_D34nuc_PP2Bnuc_off | included |
| PP1nuc_D3497nuc_PP2Bnuc_nuc2cyto | included |
| D97cyto_PP2Apcyto_on | included |
| cAMP4_R2_releasecAMP | included |
| PP2Anuc_PKAnuc_nuc2cyto | included |
| D34nuc_PP2Bnuc_off | included |
| D97cyto_PP2Apcyto_cat | included |
| PP1cyto_D3497cyto_PP2Bcyto_cat | included |
| cAMP_R2C2_onoff | included |
| D3497nuc_PP2Bnuc_cat | included |
| D34nuc_CK2_on | included |
| D97nuc_PP2Apnuc_off | included |
| D34cyto_PP2Bcyto_cyto2nuc | included |
| cAMP4_R2C_PKA_onoff | included |
| cAMP_cAMP2_R2C2_onoff | included |
| cAMP4_R2_PKA_onoff | included |
| D97nuc2cyto_passive | included |
| Dcyto_PKAcyto_cyto2nuc | included |
| PP2Apnuc2cyto | included |
| PP2Anuc_PKANuc_off | included |
| PKAcyto2nuc | included |
| PP2Acyto_PKAcyto_cyto2nuc | included |
| PP1cyto_D3497cyto_on | included |
| D97nuc_PP2Apnuc_nuc2cyto | included |
| PP2Apcytodephosphorylation | included |
| PP2Bcyto2nuc | included |
| PP1cyto_D3497cyto_PP2Bcyto_on | included |
| PP1nuc_D34nuc_PP2Bnuc_on | included |
| D97nuc_PP2Apnuc_on | included |
| D34cyto2nuc | included |
| PP2Acyto2nuc | included |
| PP1cyto_D3497cyto_PP2Bcyto_off | included |
| PP1nuc2cyto | included |
| D97cyto2nuc_passive | included |
| cAMP_cAMP_R2C2_onoff | included |
| PP1cyto_D3497cyto_cyto2nuc | included |
| PP1nuc_D3497nuc_nuc2cyto | included |
| D34cyto_PP2Bcyto_cat | included |
| D34cyto_PP2Bcyto_on | included |
| D3497nuc_PP2Bnuc_off | included |
| D3497cyto2nuc_passive | included |
| D34nuc2cyto_passive | included |
| D97cyto_PKAcyto_cyto2nuc | included |
| D3497nuc_PP2Apnuc_off | included |
| PP2Apnucdephosphorylation | included |
| PP1nuc_D3497nuc_on | included |
| D97cyto_PKAcyto_on | included |
| PP1cyto_D34cyto_on | included |
| D97cyto2nuc | included |
| Dnuc_PKAnuc_off | included |
| cAMP_cAMP3_R2C2_onoff | included |
| D3497cyto_PP2Apcyto_cyto2nuc | included |
| D3497nuc_PP2Apnuc_nuc2cyto | included |
| D97cyto_PKAcyto_cat | included |
| D97nuc_PKAnuc_off | included |
| cAMP_PDE10A_onoff | included |
| Name | End Time | Output Options |
|---|---|---|
| cAMPsecondaryEnd | 3600.0 [s] |
OutputTimeStep 5.0 |
| Dimension | Type | Subdomain | Adjacent Subvolumes | Size | Mapped Compartment |
|---|---|---|---|---|---|
| Volume | Analytical | subdomain2 | 301.60068965661543 [um3] | nucleus | |
| Volume | Analytical | subdomain1 | 1202.1930494498022 [um3] | cytosol | |
| Volume | Analytical | subdomain0 | 66696.20626089358 [um3] | c0 | |
| Surface | subdomain0_subdomain1_membrane | subdomain0 | subdomain1 | 1432.4688299433924 [um2] | cellmembrane | |
| Surface | subdomain1_subdomain2_membrane | subdomain1 | subdomain2 | 211.84616618489457 [um2] | nucleusmembrane |
Application - cAMPinput_primary3
| Species | Initial Condition | Diffusion Constant | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| cAMPsource | (200.0 * (t < 5.0) * ((x >= 43.5) && (x <= 45.3) && (y >= 4.5) && (y <= 5.5) && (z >= 5.0) && (z <= 5.5))) [uM] | 0.0
[um2/s] | D3497cyto |
0.0
[uM]
|
D_d32
[um2/s] | PP1cyto |
5.0
[uM]
|
D_pp1
[um2/s] | PP1cyto_D34cyto |
0.0
[uM]
|
D_d32pp1
[um2/s] | Dcyto |
0.0
[uM]
|
D_d32
[um2/s] | D97cyto_PP2Apcyto |
0.0
[uM]
|
D_d32pp2a
[um2/s] | R2 |
0.0
[uM]
|
D_r2
[um2/s] | PP2Bcyto |
1.6
[uM]
|
D_pp2b
[um2/s] | PP1cyto_D3497cyto_PP2Bcyto |
0.0
[uM]
|
D_d32pp1pp2b
[um2/s] | PDE10A |
1.0
[uM]
|
D_pde10a
[um2/s] | cAMP_PDE10A |
0.0
[uM]
|
D_pde10a
[um2/s] | D97cyto_PKAcyto |
0.0
[uM]
|
D_d32pkac
[um2/s] | PP1cyto_D34cyto_PP2Bcyto |
0.0
[uM]
|
D_d32pp1pp2b
[um2/s] | AMP |
0.0
[uM]
|
0.0
[um2/s] | cAMP |
0.0
[uM]
|
100.0
[um2/s] | DMNB_cAMP |
0.0
[uM]
|
100.0
[um2/s] | light_spot |
0.0
[uM]
|
0.0
[um2/s] | R2C |
0.0
[uM]
|
D_r2c
[um2/s] | cAMP4_R2C2 |
0.0
[uM]
|
D_r2c2
[um2/s] | cAMP4_R2C |
0.0
[uM]
|
D_r2c
[um2/s] | cAMP3_R2C2 |
0.0
[uM]
|
D_r2c2
[um2/s] | cAMP_R2C2 |
0.0
[uM]
|
D_r2c2
[um2/s] | cAMP2_R2C2 |
0.0
[uM]
|
D_r2c2
[um2/s] | D34cyto_PP2Bcyto |
0.0
[uM]
|
D_d32pp2b
[um2/s] | PKAcyto |
0.0
[uM]
|
D_pkac
[um2/s] | D3497cyto_PP2Apcyto |
0.0
[uM]
|
D_d32pp2a
[um2/s] | Dcyto_PKAcyto |
0.0
[uM]
|
D_d32pkac
[um2/s] | PP2Acyto_PKAcyto |
0.0
[uM]
|
D_pp2apka
[um2/s] | PP2Acyto |
2.0
[uM]
|
D_pp2a
[um2/s] | cAMP4_R2 |
0.0
[uM]
|
D_r2
[um2/s] | PP2Apcyto |
0.0
[uM]
|
D_pp2a
[um2/s] | D97cyto |
50.0
[uM]
|
D_d32
[um2/s] | PP1cyto_D3497cyto |
0.0
[uM]
|
D_d32pp1
[um2/s] | D34cyto |
0.0
[uM]
|
D_d32
[um2/s] | R2C2 |
1.0
[uM]
|
D_r2c2
[um2/s] | D3497cyto_PP2Bcyto |
0.0
[uM]
|
D_d32pp2b
[um2/s] | PP2Anuc |
2.0
[uM]
|
D_pp2a
[um2/s] | Dnuc_PKAnuc |
0.0
[uM]
|
D_d32pkac
[um2/s] | D97nuc_PP2Apnuc |
0.0
[uM]
|
D_d32pp2a
[um2/s] | PP1nuc_D34nuc_PP2Bnuc |
0.0
[uM]
|
D_d32pp1pp2b
[um2/s] | D34nuc_CK2 |
0.0
[uM]
|
D_d32ck2
[um2/s] | Dnuc_CK2 |
0.0
[uM]
|
D_d32ck2
[um2/s] | PP2Anuc_PKAnuc |
0.0
[uM]
|
D_pp2apka
[um2/s] | Dnuc |
0.0
[uM]
|
D_d32
[um2/s] | D34nuc_PP2Bnuc |
0.0
[uM]
|
D_d32pp2b
[um2/s] | PP1nuc |
5.0
[uM]
|
D_pp1
[um2/s] | PP1nuc_D34nuc |
0.0
[uM]
|
D_d32pp1
[um2/s] | PP1nuc_D3497nuc |
0.0
[uM]
|
D_d32pp1
[um2/s] | PP1nuc_D3497nuc_PP2Bnuc |
0.0
[uM]
|
D_d32pp1pp2b
[um2/s] | D3497nuc_PP2Apnuc |
0.0
[uM]
|
D_d32pp2a
[um2/s] | D97nuc |
30.0
[uM]
|
D_d32
[um2/s] | D3497nuc_PP2Bnuc |
0.0
[uM]
|
D_d32pp2b
[um2/s] | CK2 |
1.0
[uM]
|
D_ck2
[um2/s] | PP2Apnuc |
0.0
[uM]
|
D_pp2a
[um2/s] | PP2Bnuc |
1.6
[uM]
|
D_pp2b
[um2/s] | D34nuc |
0.0
[uM]
|
D_d32
[um2/s] | D3497nuc |
0.0
[uM]
|
D_d32
[um2/s] | PKAnuc |
0.0
[uM]
|
D_pkac
[um2/s] | D97nuc_PKAnuc |
0.0
[uM]
|
D_d32pkac
[um2/s]
|
|
| Name | Reaction Mapping |
|---|---|
| PP1nuc_D34nuc_off | included |
| D3497cyto_PP2Bcyto_off | included |
| PP1nuc_D3497nuc_off | included |
| PP1cyto_D34cyto_PP2Bcyto_cyto2nuc | included |
| PP2Apcyto2nuc | included |
| D97cyto_PKAcyto_off | included |
| PP1cyto_D3497cyto_PP2Bcyto_cyto2nuc | included |
| D97cyto_PP2Apcyto_off | included |
| D97nuc2cyto | included |
| D3497cyto_PP2Apcyto_on | included |
| Dcyto2nuc_passive | included |
| D34cyto2nuc_passive | included |
| D3497cyto_PP2Bcyto_on | included |
| PP1nuc_D34nuc_nuc2cyto | included |
| Dnuc_CK2_cat | included |
| D3497nuc2cyto | included |
| D97nuc_PKAnuc_cat | included |
| PP2Anuc_PKAnuc_cat | included |
| D97nuc_PP2Apnuc_cat | included |
| PP1nuc_D3497nuc_PP2Bnuc_cat | included |
| PP1nuc_D3497nuc_PP2Bnuc_off | included |
| PP1cyto_D34cyto_PP2Bcyto_cat | included |
| D3497cyto2nuc | included |
| D3497nuc2cyto_passive | included |
| D3497nuc_PP2Bnuc_on | included |
| PP2Anuc2cyto | included |
| PP2Acyto_PKAcyto_cat | included |
| PP2Acyto_PKAcyto_off | included |
| D34nuc_CK2_cat | included |
| Dnuc2cyto_passive | included |
| Dnuc_CK2_off | included |
| photoUncaging_DMNB_cAMP | included |
| Dcyto_PKAcyto_on | included |
| Dnuc_PKAnuc_cat | included |
| D97nuc_PKAnuc_on | included |
| D3497cyto_PP2Bcyto_cyto2nuc | included |
| PP1cyto_D34cyto_PP2Bcyto_on | included |
| D34nuc_PP2Bnuc_on | included |
| R2_PKAcyto_bind | included |
| Dcyto_PKAcyto_off | included |
| D3497cyto_PP2Apcyto_cat | included |
| PP2Anuc_PKAnuc_on | included |
| PP2Bnuc2cyto | included |
| PP2Acyto_PKAcyto_on | included |
| PP1nuc_D3497nuc_PP2Bnuc_on | included |
| R2C_PKAcyto_bind | included |
| PP1cyto_D3497_off | included |
| D3497cyto_PP2Bcyto_cat | included |
| PP1nuc_D34nuc_PP2Bnuc_cat | included |
| PP1nuc_D34nuc_on | included |
| Dcyto_PKAcyto_cat | included |
| PP1cyto_D34cyto_PP2Bcyto_off | included |
| D97cyto_PP2Apcyto_cyto2nuc | included |
| Dnuc_CK2_on | included |
| PP1cyto_D34cyto_cyto2nuc | included |
| D3497nuc_PP2Bnuc_nuc2cyto | included |
| D3497nuc_PP2Apnuc_cat | included |
| D34nuc_PP2Bnuc_cat | included |
| Dcyto2nuc | included |
| cAMPsource2cAMP | included |
| D97nuc_PKAnuc_nuc2cyto | included |
| cAMP_PDE10A_cat | included |
| PP1cyto_D34cyto_off | included |
| PKAnuc2cyto | included |
| D3497nuc_PP2Apnuc_on | included |
| Dnuc_PKAnuc_on | included |
| D34cyto_PP2Bcyto_off | included |
| D3497cyto_PP2Apcyto_off | included |
| PP1cyto2nuc | included |
| D34nuc_CK2_off | included |
| PP1nuc_D34nuc_PP2Bnuc_off | included |
| PP1nuc_D3497nuc_PP2Bnuc_nuc2cyto | included |
| D97cyto_PP2Apcyto_on | included |
| cAMP4_R2_releasecAMP | included |
| PP2Anuc_PKAnuc_nuc2cyto | included |
| D34nuc_PP2Bnuc_off | included |
| D97cyto_PP2Apcyto_cat | included |
| PP1cyto_D3497cyto_PP2Bcyto_cat | included |
| cAMP_R2C2_onoff | included |
| D3497nuc_PP2Bnuc_cat | included |
| D34nuc_CK2_on | included |
| D97nuc_PP2Apnuc_off | included |
| D34cyto_PP2Bcyto_cyto2nuc | included |
| cAMP4_R2C_PKA_onoff | included |
| cAMP_cAMP2_R2C2_onoff | included |
| cAMP4_R2_PKA_onoff | included |
| D97nuc2cyto_passive | included |
| Dcyto_PKAcyto_cyto2nuc | included |
| PP2Apnuc2cyto | included |
| PP2Anuc_PKANuc_off | included |
| PKAcyto2nuc | included |
| PP2Acyto_PKAcyto_cyto2nuc | included |
| PP1cyto_D3497cyto_on | included |
| D97nuc_PP2Apnuc_nuc2cyto | included |
| PP2Apcytodephosphorylation | included |
| PP2Bcyto2nuc | included |
| PP1cyto_D3497cyto_PP2Bcyto_on | included |
| PP1nuc_D34nuc_PP2Bnuc_on | included |
| D97nuc_PP2Apnuc_on | included |
| D34cyto2nuc | included |
| PP2Acyto2nuc | included |
| PP1cyto_D3497cyto_PP2Bcyto_off | included |
| PP1nuc2cyto | included |
| D97cyto2nuc_passive | included |
| cAMP_cAMP_R2C2_onoff | included |
| PP1cyto_D3497cyto_cyto2nuc | included |
| PP1nuc_D3497nuc_nuc2cyto | included |
| D34cyto_PP2Bcyto_cat | included |
| D34cyto_PP2Bcyto_on | included |
| D3497nuc_PP2Bnuc_off | included |
| D3497cyto2nuc_passive | included |
| D34nuc2cyto_passive | included |
| D97cyto_PKAcyto_cyto2nuc | included |
| D3497nuc_PP2Apnuc_off | included |
| PP2Apnucdephosphorylation | included |
| PP1nuc_D3497nuc_on | included |
| D97cyto_PKAcyto_on | included |
| PP1cyto_D34cyto_on | included |
| D97cyto2nuc | included |
| Dnuc_PKAnuc_off | included |
| cAMP_cAMP3_R2C2_onoff | included |
| D3497cyto_PP2Apcyto_cyto2nuc | included |
| D3497nuc_PP2Apnuc_nuc2cyto | included |
| D97cyto_PKAcyto_cat | included |
| D97nuc_PKAnuc_off | included |
| cAMP_PDE10A_onoff | included |
| Name | End Time | Output Options |
|---|---|---|
| cAMPprimaryEnd | 3600.0 [s] |
OutputTimeStep 5.0 |
| Dimension | Type | Subdomain | Adjacent Subvolumes | Size | Mapped Compartment |
|---|---|---|---|---|---|
| Volume | Analytical | subdomain2 | 301.60068965661543 [um3] | nucleus | |
| Volume | Analytical | subdomain1 | 1202.1930494498022 [um3] | cytosol | |
| Volume | Analytical | subdomain0 | 66696.20626089358 [um3] | c0 | |
| Surface | subdomain0_subdomain1_membrane | subdomain0 | subdomain1 | 1432.4688299433924 [um2] | cellmembrane | |
| Surface | subdomain1_subdomain2_membrane | subdomain1 | subdomain2 | 211.84616618489457 [um2] | nucleusmembrane |
Application - cAMPinput_primary1
| Species | Initial Condition | Diffusion Constant | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| cAMPsource | (200.0 * (t < 5.0) * ((x >= 20.5) && (x <= 22.3) && (y >= 4.5) && (y <= 5.5) && (z >= 5.0) && (z <= 5.5))) [uM] | 0.0
[um2/s] | D3497cyto |
0.0
[uM]
|
D_d32
[um2/s] | PP1cyto |
5.0
[uM]
|
D_pp1
[um2/s] | PP1cyto_D34cyto |
0.0
[uM]
|
D_d32pp1
[um2/s] | Dcyto |
0.0
[uM]
|
D_d32
[um2/s] | D97cyto_PP2Apcyto |
0.0
[uM]
|
D_d32pp2a
[um2/s] | R2 |
0.0
[uM]
|
D_r2
[um2/s] | PP2Bcyto |
1.6
[uM]
|
D_pp2b
[um2/s] | PP1cyto_D3497cyto_PP2Bcyto |
0.0
[uM]
|
D_d32pp1pp2b
[um2/s] | PDE10A |
1.0
[uM]
|
D_pde10a
[um2/s] | cAMP_PDE10A |
0.0
[uM]
|
D_pde10a
[um2/s] | D97cyto_PKAcyto |
0.0
[uM]
|
D_d32pkac
[um2/s] | PP1cyto_D34cyto_PP2Bcyto |
0.0
[uM]
|
D_d32pp1pp2b
[um2/s] | AMP |
0.0
[uM]
|
0.0
[um2/s] | cAMP |
0.0
[uM]
|
100.0
[um2/s] | DMNB_cAMP |
0.0
[uM]
|
100.0
[um2/s] | light_spot |
0.0
[uM]
|
0.0
[um2/s] | R2C |
0.0
[uM]
|
D_r2c
[um2/s] | cAMP4_R2C2 |
0.0
[uM]
|
D_r2c2
[um2/s] | cAMP4_R2C |
0.0
[uM]
|
D_r2c
[um2/s] | cAMP3_R2C2 |
0.0
[uM]
|
D_r2c2
[um2/s] | cAMP_R2C2 |
0.0
[uM]
|
D_r2c2
[um2/s] | cAMP2_R2C2 |
0.0
[uM]
|
D_r2c2
[um2/s] | D34cyto_PP2Bcyto |
0.0
[uM]
|
D_d32pp2b
[um2/s] | PKAcyto |
0.0
[uM]
|
D_pkac
[um2/s] | D3497cyto_PP2Apcyto |
0.0
[uM]
|
D_d32pp2a
[um2/s] | Dcyto_PKAcyto |
0.0
[uM]
|
D_d32pkac
[um2/s] | PP2Acyto_PKAcyto |
0.0
[uM]
|
D_pp2apka
[um2/s] | PP2Acyto |
2.0
[uM]
|
D_pp2a
[um2/s] | cAMP4_R2 |
0.0
[uM]
|
D_r2
[um2/s] | PP2Apcyto |
0.0
[uM]
|
D_pp2a
[um2/s] | D97cyto |
50.0
[uM]
|
D_d32
[um2/s] | PP1cyto_D3497cyto |
0.0
[uM]
|
D_d32pp1
[um2/s] | D34cyto |
0.0
[uM]
|
D_d32
[um2/s] | R2C2 |
1.0
[uM]
|
D_r2c2
[um2/s] | D3497cyto_PP2Bcyto |
0.0
[uM]
|
D_d32pp2b
[um2/s] | PP2Anuc |
2.0
[uM]
|
D_pp2a
[um2/s] | Dnuc_PKAnuc |
0.0
[uM]
|
D_d32pkac
[um2/s] | D97nuc_PP2Apnuc |
0.0
[uM]
|
D_d32pp2a
[um2/s] | PP1nuc_D34nuc_PP2Bnuc |
0.0
[uM]
|
D_d32pp1pp2b
[um2/s] | D34nuc_CK2 |
0.0
[uM]
|
D_d32ck2
[um2/s] | Dnuc_CK2 |
0.0
[uM]
|
D_d32ck2
[um2/s] | PP2Anuc_PKAnuc |
0.0
[uM]
|
D_pp2apka
[um2/s] | Dnuc |
0.0
[uM]
|
D_d32
[um2/s] | D34nuc_PP2Bnuc |
0.0
[uM]
|
D_d32pp2b
[um2/s] | PP1nuc |
5.0
[uM]
|
D_pp1
[um2/s] | PP1nuc_D34nuc |
0.0
[uM]
|
D_d32pp1
[um2/s] | PP1nuc_D3497nuc |
0.0
[uM]
|
D_d32pp1
[um2/s] | PP1nuc_D3497nuc_PP2Bnuc |
0.0
[uM]
|
D_d32pp1pp2b
[um2/s] | D3497nuc_PP2Apnuc |
0.0
[uM]
|
D_d32pp2a
[um2/s] | D97nuc |
30.0
[uM]
|
D_d32
[um2/s] | D3497nuc_PP2Bnuc |
0.0
[uM]
|
D_d32pp2b
[um2/s] | CK2 |
1.0
[uM]
|
D_ck2
[um2/s] | PP2Apnuc |
0.0
[uM]
|
D_pp2a
[um2/s] | PP2Bnuc |
1.6
[uM]
|
D_pp2b
[um2/s] | D34nuc |
0.0
[uM]
|
D_d32
[um2/s] | D3497nuc |
0.0
[uM]
|
D_d32
[um2/s] | PKAnuc |
0.0
[uM]
|
D_pkac
[um2/s] | D97nuc_PKAnuc |
0.0
[uM]
|
D_d32pkac
[um2/s]
|
|
| Name | Reaction Mapping |
|---|---|
| PP1nuc_D34nuc_off | included |
| D3497cyto_PP2Bcyto_off | included |
| PP1nuc_D3497nuc_off | included |
| PP1cyto_D34cyto_PP2Bcyto_cyto2nuc | included |
| PP2Apcyto2nuc | included |
| D97cyto_PKAcyto_off | included |
| PP1cyto_D3497cyto_PP2Bcyto_cyto2nuc | included |
| D97cyto_PP2Apcyto_off | included |
| D97nuc2cyto | included |
| D3497cyto_PP2Apcyto_on | included |
| Dcyto2nuc_passive | included |
| D34cyto2nuc_passive | included |
| D3497cyto_PP2Bcyto_on | included |
| PP1nuc_D34nuc_nuc2cyto | included |
| Dnuc_CK2_cat | included |
| D3497nuc2cyto | included |
| D97nuc_PKAnuc_cat | included |
| PP2Anuc_PKAnuc_cat | included |
| D97nuc_PP2Apnuc_cat | included |
| PP1nuc_D3497nuc_PP2Bnuc_cat | included |
| PP1nuc_D3497nuc_PP2Bnuc_off | included |
| PP1cyto_D34cyto_PP2Bcyto_cat | included |
| D3497cyto2nuc | included |
| D3497nuc2cyto_passive | included |
| D3497nuc_PP2Bnuc_on | included |
| PP2Anuc2cyto | included |
| PP2Acyto_PKAcyto_cat | included |
| PP2Acyto_PKAcyto_off | included |
| D34nuc_CK2_cat | included |
| Dnuc2cyto_passive | included |
| Dnuc_CK2_off | included |
| photoUncaging_DMNB_cAMP | included |
| Dcyto_PKAcyto_on | included |
| Dnuc_PKAnuc_cat | included |
| D97nuc_PKAnuc_on | included |
| D3497cyto_PP2Bcyto_cyto2nuc | included |
| PP1cyto_D34cyto_PP2Bcyto_on | included |
| D34nuc_PP2Bnuc_on | included |
| R2_PKAcyto_bind | included |
| Dcyto_PKAcyto_off | included |
| D3497cyto_PP2Apcyto_cat | included |
| PP2Anuc_PKAnuc_on | included |
| PP2Bnuc2cyto | included |
| PP2Acyto_PKAcyto_on | included |
| PP1nuc_D3497nuc_PP2Bnuc_on | included |
| R2C_PKAcyto_bind | included |
| PP1cyto_D3497_off | included |
| D3497cyto_PP2Bcyto_cat | included |
| PP1nuc_D34nuc_PP2Bnuc_cat | included |
| PP1nuc_D34nuc_on | included |
| Dcyto_PKAcyto_cat | included |
| PP1cyto_D34cyto_PP2Bcyto_off | included |
| D97cyto_PP2Apcyto_cyto2nuc | included |
| Dnuc_CK2_on | included |
| PP1cyto_D34cyto_cyto2nuc | included |
| D3497nuc_PP2Bnuc_nuc2cyto | included |
| D3497nuc_PP2Apnuc_cat | included |
| D34nuc_PP2Bnuc_cat | included |
| Dcyto2nuc | included |
| cAMPsource2cAMP | included |
| D97nuc_PKAnuc_nuc2cyto | included |
| cAMP_PDE10A_cat | included |
| PP1cyto_D34cyto_off | included |
| PKAnuc2cyto | included |
| D3497nuc_PP2Apnuc_on | included |
| Dnuc_PKAnuc_on | included |
| D34cyto_PP2Bcyto_off | included |
| D3497cyto_PP2Apcyto_off | included |
| PP1cyto2nuc | included |
| D34nuc_CK2_off | included |
| PP1nuc_D34nuc_PP2Bnuc_off | included |
| PP1nuc_D3497nuc_PP2Bnuc_nuc2cyto | included |
| D97cyto_PP2Apcyto_on | included |
| cAMP4_R2_releasecAMP | included |
| PP2Anuc_PKAnuc_nuc2cyto | included |
| D34nuc_PP2Bnuc_off | included |
| D97cyto_PP2Apcyto_cat | included |
| PP1cyto_D3497cyto_PP2Bcyto_cat | included |
| cAMP_R2C2_onoff | included |
| D3497nuc_PP2Bnuc_cat | included |
| D34nuc_CK2_on | included |
| D97nuc_PP2Apnuc_off | included |
| D34cyto_PP2Bcyto_cyto2nuc | included |
| cAMP4_R2C_PKA_onoff | included |
| cAMP_cAMP2_R2C2_onoff | included |
| cAMP4_R2_PKA_onoff | included |
| D97nuc2cyto_passive | included |
| Dcyto_PKAcyto_cyto2nuc | included |
| PP2Apnuc2cyto | included |
| PP2Anuc_PKANuc_off | included |
| PKAcyto2nuc | included |
| PP2Acyto_PKAcyto_cyto2nuc | included |
| PP1cyto_D3497cyto_on | included |
| D97nuc_PP2Apnuc_nuc2cyto | included |
| PP2Apcytodephosphorylation | included |
| PP2Bcyto2nuc | included |
| PP1cyto_D3497cyto_PP2Bcyto_on | included |
| PP1nuc_D34nuc_PP2Bnuc_on | included |
| D97nuc_PP2Apnuc_on | included |
| D34cyto2nuc | included |
| PP2Acyto2nuc | included |
| PP1cyto_D3497cyto_PP2Bcyto_off | included |
| PP1nuc2cyto | included |
| D97cyto2nuc_passive | included |
| cAMP_cAMP_R2C2_onoff | included |
| PP1cyto_D3497cyto_cyto2nuc | included |
| PP1nuc_D3497nuc_nuc2cyto | included |
| D34cyto_PP2Bcyto_cat | included |
| D34cyto_PP2Bcyto_on | included |
| D3497nuc_PP2Bnuc_off | included |
| D3497cyto2nuc_passive | included |
| D34nuc2cyto_passive | included |
| D97cyto_PKAcyto_cyto2nuc | included |
| D3497nuc_PP2Apnuc_off | included |
| PP2Apnucdephosphorylation | included |
| PP1nuc_D3497nuc_on | included |
| D97cyto_PKAcyto_on | included |
| PP1cyto_D34cyto_on | included |
| D97cyto2nuc | included |
| Dnuc_PKAnuc_off | included |
| cAMP_cAMP3_R2C2_onoff | included |
| D3497cyto_PP2Apcyto_cyto2nuc | included |
| D3497nuc_PP2Apnuc_nuc2cyto | included |
| D97cyto_PKAcyto_cat | included |
| D97nuc_PKAnuc_off | included |
| cAMP_PDE10A_onoff | included |
| Name | End Time | Output Options |
|---|---|---|
| cAMPprimaryBegin | 3600.0 [s] |
OutputTimeStep 5.0 |
| Dimension | Type | Subdomain | Adjacent Subvolumes | Size | Mapped Compartment |
|---|---|---|---|---|---|
| Volume | Analytical | subdomain2 | 301.60068965661543 [um3] | nucleus | |
| Volume | Analytical | subdomain1 | 1202.1930494498022 [um3] | cytosol | |
| Volume | Analytical | subdomain0 | 66696.20626089358 [um3] | c0 | |
| Surface | subdomain0_subdomain1_membrane | subdomain0 | subdomain1 | 1432.4688299433924 [um2] | cellmembrane | |
| Surface | subdomain1_subdomain2_membrane | subdomain1 | subdomain2 | 211.84616618489457 [um2] | nucleusmembrane |
Application - cAMPinput_primary2
| Species | Initial Condition | Diffusion Constant | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| cAMPsource | (200.0 * ((x >= 32.5) && (x <= 34.3) && (y >= 4.5) && (y <= 5.5) && (z >= 5.0) && (z <= 5.5)) * (t < 5.0)) [uM] | 0.0
[um2/s] | D3497cyto |
0.0
[uM]
|
D_d32
[um2/s] | PP1cyto |
5.0
[uM]
|
D_pp1
[um2/s] | PP1cyto_D34cyto |
0.0
[uM]
|
D_d32pp1
[um2/s] | Dcyto |
0.0
[uM]
|
D_d32
[um2/s] | D97cyto_PP2Apcyto |
0.0
[uM]
|
D_d32pp2a
[um2/s] | R2 |
0.0
[uM]
|
D_r2
[um2/s] | PP2Bcyto |
1.6
[uM]
|
D_pp2b
[um2/s] | PP1cyto_D3497cyto_PP2Bcyto |
0.0
[uM]
|
D_d32pp1pp2b
[um2/s] | PDE10A |
1.0
[uM]
|
D_pde10a
[um2/s] | cAMP_PDE10A |
0.0
[uM]
|
D_pde10a
[um2/s] | D97cyto_PKAcyto |
0.0
[uM]
|
D_d32pkac
[um2/s] | PP1cyto_D34cyto_PP2Bcyto |
0.0
[uM]
|
D_d32pp1pp2b
[um2/s] | AMP |
0.0
[uM]
|
0.0
[um2/s] | cAMP |
0.0
[uM]
|
100.0
[um2/s] | DMNB_cAMP |
0.0
[uM]
|
100.0
[um2/s] | light_spot |
0.0
[uM]
|
0.0
[um2/s] | R2C |
0.0
[uM]
|
D_r2c
[um2/s] | cAMP4_R2C2 |
0.0
[uM]
|
D_r2c2
[um2/s] | cAMP4_R2C |
0.0
[uM]
|
D_r2c
[um2/s] | cAMP3_R2C2 |
0.0
[uM]
|
D_r2c2
[um2/s] | cAMP_R2C2 |
0.0
[uM]
|
D_r2c2
[um2/s] | cAMP2_R2C2 |
0.0
[uM]
|
D_r2c2
[um2/s] | D34cyto_PP2Bcyto |
0.0
[uM]
|
D_d32pp2b
[um2/s] | PKAcyto |
0.0
[uM]
|
D_pkac
[um2/s] | D3497cyto_PP2Apcyto |
0.0
[uM]
|
D_d32pp2a
[um2/s] | Dcyto_PKAcyto |
0.0
[uM]
|
D_d32pkac
[um2/s] | PP2Acyto_PKAcyto |
0.0
[uM]
|
D_pp2apka
[um2/s] | PP2Acyto |
2.0
[uM]
|
D_pp2a
[um2/s] | cAMP4_R2 |
0.0
[uM]
|
D_r2
[um2/s] | PP2Apcyto |
0.0
[uM]
|
D_pp2a
[um2/s] | D97cyto |
50.0
[uM]
|
D_d32
[um2/s] | PP1cyto_D3497cyto |
0.0
[uM]
|
D_d32pp1
[um2/s] | D34cyto |
0.0
[uM]
|
D_d32
[um2/s] | R2C2 |
1.0
[uM]
|
D_r2c2
[um2/s] | D3497cyto_PP2Bcyto |
0.0
[uM]
|
D_d32pp2b
[um2/s] | PP2Anuc |
2.0
[uM]
|
D_pp2a
[um2/s] | Dnuc_PKAnuc |
0.0
[uM]
|
D_d32pkac
[um2/s] | D97nuc_PP2Apnuc |
0.0
[uM]
|
D_d32pp2a
[um2/s] | PP1nuc_D34nuc_PP2Bnuc |
0.0
[uM]
|
D_d32pp1pp2b
[um2/s] | D34nuc_CK2 |
0.0
[uM]
|
D_d32ck2
[um2/s] | Dnuc_CK2 |
0.0
[uM]
|
D_d32ck2
[um2/s] | PP2Anuc_PKAnuc |
0.0
[uM]
|
D_pp2apka
[um2/s] | Dnuc |
0.0
[uM]
|
D_d32
[um2/s] | D34nuc_PP2Bnuc |
0.0
[uM]
|
D_d32pp2b
[um2/s] | PP1nuc |
5.0
[uM]
|
D_pp1
[um2/s] | PP1nuc_D34nuc |
0.0
[uM]
|
D_d32pp1
[um2/s] | PP1nuc_D3497nuc |
0.0
[uM]
|
D_d32pp1
[um2/s] | PP1nuc_D3497nuc_PP2Bnuc |
0.0
[uM]
|
D_d32pp1pp2b
[um2/s] | D3497nuc_PP2Apnuc |
0.0
[uM]
|
D_d32pp2a
[um2/s] | D97nuc |
30.0
[uM]
|
D_d32
[um2/s] | D3497nuc_PP2Bnuc |
0.0
[uM]
|
D_d32pp2b
[um2/s] | CK2 |
1.0
[uM]
|
D_ck2
[um2/s] | PP2Apnuc |
0.0
[uM]
|
D_pp2a
[um2/s] | PP2Bnuc |
1.6
[uM]
|
D_pp2b
[um2/s] | D34nuc |
0.0
[uM]
|
D_d32
[um2/s] | D3497nuc |
0.0
[uM]
|
D_d32
[um2/s] | PKAnuc |
0.0
[uM]
|
D_pkac
[um2/s] | D97nuc_PKAnuc |
0.0
[uM]
|
D_d32pkac
[um2/s]
|
|
| Name | Reaction Mapping |
|---|---|
| PP1nuc_D34nuc_off | included |
| D3497cyto_PP2Bcyto_off | included |
| PP1nuc_D3497nuc_off | included |
| PP1cyto_D34cyto_PP2Bcyto_cyto2nuc | included |
| PP2Apcyto2nuc | included |
| D97cyto_PKAcyto_off | included |
| PP1cyto_D3497cyto_PP2Bcyto_cyto2nuc | included |
| D97cyto_PP2Apcyto_off | included |
| D97nuc2cyto | included |
| D3497cyto_PP2Apcyto_on | included |
| Dcyto2nuc_passive | included |
| D34cyto2nuc_passive | included |
| D3497cyto_PP2Bcyto_on | included |
| PP1nuc_D34nuc_nuc2cyto | included |
| Dnuc_CK2_cat | included |
| D3497nuc2cyto | included |
| D97nuc_PKAnuc_cat | included |
| PP2Anuc_PKAnuc_cat | included |
| D97nuc_PP2Apnuc_cat | included |
| PP1nuc_D3497nuc_PP2Bnuc_cat | included |
| PP1nuc_D3497nuc_PP2Bnuc_off | included |
| PP1cyto_D34cyto_PP2Bcyto_cat | included |
| D3497cyto2nuc | included |
| D3497nuc2cyto_passive | included |
| D3497nuc_PP2Bnuc_on | included |
| PP2Anuc2cyto | included |
| PP2Acyto_PKAcyto_cat | included |
| PP2Acyto_PKAcyto_off | included |
| D34nuc_CK2_cat | included |
| Dnuc2cyto_passive | included |
| Dnuc_CK2_off | included |
| photoUncaging_DMNB_cAMP | included |
| Dcyto_PKAcyto_on | included |
| Dnuc_PKAnuc_cat | included |
| D97nuc_PKAnuc_on | included |
| D3497cyto_PP2Bcyto_cyto2nuc | included |
| PP1cyto_D34cyto_PP2Bcyto_on | included |
| D34nuc_PP2Bnuc_on | included |
| R2_PKAcyto_bind | included |
| Dcyto_PKAcyto_off | included |
| D3497cyto_PP2Apcyto_cat | included |
| PP2Anuc_PKAnuc_on | included |
| PP2Bnuc2cyto | included |
| PP2Acyto_PKAcyto_on | included |
| PP1nuc_D3497nuc_PP2Bnuc_on | included |
| R2C_PKAcyto_bind | included |
| PP1cyto_D3497_off | included |
| D3497cyto_PP2Bcyto_cat | included |
| PP1nuc_D34nuc_PP2Bnuc_cat | included |
| PP1nuc_D34nuc_on | included |
| Dcyto_PKAcyto_cat | included |
| PP1cyto_D34cyto_PP2Bcyto_off | included |
| D97cyto_PP2Apcyto_cyto2nuc | included |
| Dnuc_CK2_on | included |
| PP1cyto_D34cyto_cyto2nuc | included |
| D3497nuc_PP2Bnuc_nuc2cyto | included |
| D3497nuc_PP2Apnuc_cat | included |
| D34nuc_PP2Bnuc_cat | included |
| Dcyto2nuc | included |
| cAMPsource2cAMP | included |
| D97nuc_PKAnuc_nuc2cyto | included |
| cAMP_PDE10A_cat | included |
| PP1cyto_D34cyto_off | included |
| PKAnuc2cyto | included |
| D3497nuc_PP2Apnuc_on | included |
| Dnuc_PKAnuc_on | included |
| D34cyto_PP2Bcyto_off | included |
| D3497cyto_PP2Apcyto_off | included |
| PP1cyto2nuc | included |
| D34nuc_CK2_off | included |
| PP1nuc_D34nuc_PP2Bnuc_off | included |
| PP1nuc_D3497nuc_PP2Bnuc_nuc2cyto | included |
| D97cyto_PP2Apcyto_on | included |
| cAMP4_R2_releasecAMP | included |
| PP2Anuc_PKAnuc_nuc2cyto | included |
| D34nuc_PP2Bnuc_off | included |
| D97cyto_PP2Apcyto_cat | included |
| PP1cyto_D3497cyto_PP2Bcyto_cat | included |
| cAMP_R2C2_onoff | included |
| D3497nuc_PP2Bnuc_cat | included |
| D34nuc_CK2_on | included |
| D97nuc_PP2Apnuc_off | included |
| D34cyto_PP2Bcyto_cyto2nuc | included |
| cAMP4_R2C_PKA_onoff | included |
| cAMP_cAMP2_R2C2_onoff | included |
| cAMP4_R2_PKA_onoff | included |
| D97nuc2cyto_passive | included |
| Dcyto_PKAcyto_cyto2nuc | included |
| PP2Apnuc2cyto | included |
| PP2Anuc_PKANuc_off | included |
| PKAcyto2nuc | included |
| PP2Acyto_PKAcyto_cyto2nuc | included |
| PP1cyto_D3497cyto_on | included |
| D97nuc_PP2Apnuc_nuc2cyto | included |
| PP2Apcytodephosphorylation | included |
| PP2Bcyto2nuc | included |
| PP1cyto_D3497cyto_PP2Bcyto_on | included |
| PP1nuc_D34nuc_PP2Bnuc_on | included |
| D97nuc_PP2Apnuc_on | included |
| D34cyto2nuc | included |
| PP2Acyto2nuc | included |
| PP1cyto_D3497cyto_PP2Bcyto_off | included |
| PP1nuc2cyto | included |
| D97cyto2nuc_passive | included |
| cAMP_cAMP_R2C2_onoff | included |
| PP1cyto_D3497cyto_cyto2nuc | included |
| PP1nuc_D3497nuc_nuc2cyto | included |
| D34cyto_PP2Bcyto_cat | included |
| D34cyto_PP2Bcyto_on | included |
| D3497nuc_PP2Bnuc_off | included |
| D3497cyto2nuc_passive | included |
| D34nuc2cyto_passive | included |
| D97cyto_PKAcyto_cyto2nuc | included |
| D3497nuc_PP2Apnuc_off | included |
| PP2Apnucdephosphorylation | included |
| PP1nuc_D3497nuc_on | included |
| D97cyto_PKAcyto_on | included |
| PP1cyto_D34cyto_on | included |
| D97cyto2nuc | included |
| Dnuc_PKAnuc_off | included |
| cAMP_cAMP3_R2C2_onoff | included |
| D3497cyto_PP2Apcyto_cyto2nuc | included |
| D3497nuc_PP2Apnuc_nuc2cyto | included |
| D97cyto_PKAcyto_cat | included |
| D97nuc_PKAnuc_off | included |
| cAMP_PDE10A_onoff | included |
| Name | End Time | Output Options |
|---|---|---|
| primaryMiddle | 3600.0 [s] |
OutputTimeStep 5.0 |
| Dimension | Type | Subdomain | Adjacent Subvolumes | Size | Mapped Compartment |
|---|---|---|---|---|---|
| Volume | Analytical | subdomain2 | 301.60068965661543 [um3] | nucleus | |
| Volume | Analytical | subdomain1 | 1202.1930494498022 [um3] | cytosol | |
| Volume | Analytical | subdomain0 | 66696.20626089358 [um3] | c0 | |
| Surface | subdomain0_subdomain1_membrane | subdomain0 | subdomain1 | 1432.4688299433924 [um2] | cellmembrane | |
| Surface | subdomain1_subdomain2_membrane | subdomain1 | subdomain2 | 211.84616618489457 [um2] | nucleusmembrane |
Application - cAMPinput_secondary1
| Species | Initial Condition | Diffusion Constant | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| cAMPsource | (200.0 * ((x >= 61.0) && (x <= 62.8) && (y >= - 1.5) && (y <= 0.0) && (z >= 5.0) && (z <= 5.5)) * (t < 5.0)) [uM] | 0.0
[um2/s] | D3497cyto |
0.0
[uM]
|
D_d32
[um2/s] | PP1cyto |
5.0
[uM]
|
D_pp1
[um2/s] | PP1cyto_D34cyto |
0.0
[uM]
|
D_d32pp1
[um2/s] | Dcyto |
0.0
[uM]
|
D_d32
[um2/s] | D97cyto_PP2Apcyto |
0.0
[uM]
|
D_d32pp2a
[um2/s] | R2 |
0.0
[uM]
|
D_r2
[um2/s] | PP2Bcyto |
1.6
[uM]
|
D_pp2b
[um2/s] | PP1cyto_D3497cyto_PP2Bcyto |
0.0
[uM]
|
D_d32pp1pp2b
[um2/s] | PDE10A |
1.0
[uM]
|
D_pde10a
[um2/s] | cAMP_PDE10A |
0.0
[uM]
|
D_pde10a
[um2/s] | D97cyto_PKAcyto |
0.0
[uM]
|
D_d32pkac
[um2/s] | PP1cyto_D34cyto_PP2Bcyto |
0.0
[uM]
|
D_d32pp1pp2b
[um2/s] | AMP |
0.0
[uM]
|
0.0
[um2/s] | cAMP |
0.0
[uM]
|
100.0
[um2/s] | DMNB_cAMP |
0.0
[uM]
|
100.0
[um2/s] | light_spot |
0.0
[uM]
|
0.0
[um2/s] | R2C |
0.0
[uM]
|
D_r2c
[um2/s] | cAMP4_R2C2 |
0.0
[uM]
|
D_r2c2
[um2/s] | cAMP4_R2C |
0.0
[uM]
|
D_r2c
[um2/s] | cAMP3_R2C2 |
0.0
[uM]
|
D_r2c2
[um2/s] | cAMP_R2C2 |
0.0
[uM]
|
D_r2c2
[um2/s] | cAMP2_R2C2 |
0.0
[uM]
|
D_r2c2
[um2/s] | D34cyto_PP2Bcyto |
0.0
[uM]
|
D_d32pp2b
[um2/s] | PKAcyto |
0.0
[uM]
|
D_pkac
[um2/s] | D3497cyto_PP2Apcyto |
0.0
[uM]
|
D_d32pp2a
[um2/s] | Dcyto_PKAcyto |
0.0
[uM]
|
D_d32pkac
[um2/s] | PP2Acyto_PKAcyto |
0.0
[uM]
|
D_pp2apka
[um2/s] | PP2Acyto |
2.0
[uM]
|
D_pp2a
[um2/s] | cAMP4_R2 |
0.0
[uM]
|
D_r2
[um2/s] | PP2Apcyto |
0.0
[uM]
|
D_pp2a
[um2/s] | D97cyto |
50.0
[uM]
|
D_d32
[um2/s] | PP1cyto_D3497cyto |
0.0
[uM]
|
D_d32pp1
[um2/s] | D34cyto |
0.0
[uM]
|
D_d32
[um2/s] | R2C2 |
1.0
[uM]
|
D_r2c2
[um2/s] | D3497cyto_PP2Bcyto |
0.0
[uM]
|
D_d32pp2b
[um2/s] | PP2Anuc |
2.0
[uM]
|
D_pp2a
[um2/s] | Dnuc_PKAnuc |
0.0
[uM]
|
D_d32pkac
[um2/s] | D97nuc_PP2Apnuc |
0.0
[uM]
|
D_d32pp2a
[um2/s] | PP1nuc_D34nuc_PP2Bnuc |
0.0
[uM]
|
D_d32pp1pp2b
[um2/s] | D34nuc_CK2 |
0.0
[uM]
|
D_d32ck2
[um2/s] | Dnuc_CK2 |
0.0
[uM]
|
D_d32ck2
[um2/s] | PP2Anuc_PKAnuc |
0.0
[uM]
|
D_pp2apka
[um2/s] | Dnuc |
0.0
[uM]
|
D_d32
[um2/s] | D34nuc_PP2Bnuc |
0.0
[uM]
|
D_d32pp2b
[um2/s] | PP1nuc |
5.0
[uM]
|
D_pp1
[um2/s] | PP1nuc_D34nuc |
0.0
[uM]
|
D_d32pp1
[um2/s] | PP1nuc_D3497nuc |
0.0
[uM]
|
D_d32pp1
[um2/s] | PP1nuc_D3497nuc_PP2Bnuc |
0.0
[uM]
|
D_d32pp1pp2b
[um2/s] | D3497nuc_PP2Apnuc |
0.0
[uM]
|
D_d32pp2a
[um2/s] | D97nuc |
30.0
[uM]
|
D_d32
[um2/s] | D3497nuc_PP2Bnuc |
0.0
[uM]
|
D_d32pp2b
[um2/s] | CK2 |
1.0
[uM]
|
D_ck2
[um2/s] | PP2Apnuc |
0.0
[uM]
|
D_pp2a
[um2/s] | PP2Bnuc |
1.6
[uM]
|
D_pp2b
[um2/s] | D34nuc |
0.0
[uM]
|
D_d32
[um2/s] | D3497nuc |
0.0
[uM]
|
D_d32
[um2/s] | PKAnuc |
0.0
[uM]
|
D_pkac
[um2/s] | D97nuc_PKAnuc |
0.0
[uM]
|
D_d32pkac
[um2/s]
|
|
| Name | Reaction Mapping |
|---|---|
| PP1nuc_D34nuc_off | included |
| D3497cyto_PP2Bcyto_off | included |
| PP1nuc_D3497nuc_off | included |
| PP1cyto_D34cyto_PP2Bcyto_cyto2nuc | included |
| PP2Apcyto2nuc | included |
| D97cyto_PKAcyto_off | included |
| PP1cyto_D3497cyto_PP2Bcyto_cyto2nuc | included |
| D97cyto_PP2Apcyto_off | included |
| D97nuc2cyto | included |
| D3497cyto_PP2Apcyto_on | included |
| Dcyto2nuc_passive | included |
| D34cyto2nuc_passive | included |
| D3497cyto_PP2Bcyto_on | included |
| PP1nuc_D34nuc_nuc2cyto | included |
| Dnuc_CK2_cat | included |
| D3497nuc2cyto | included |
| D97nuc_PKAnuc_cat | included |
| PP2Anuc_PKAnuc_cat | included |
| D97nuc_PP2Apnuc_cat | included |
| PP1nuc_D3497nuc_PP2Bnuc_cat | included |
| PP1nuc_D3497nuc_PP2Bnuc_off | included |
| PP1cyto_D34cyto_PP2Bcyto_cat | included |
| D3497cyto2nuc | included |
| D3497nuc2cyto_passive | included |
| D3497nuc_PP2Bnuc_on | included |
| PP2Anuc2cyto | included |
| PP2Acyto_PKAcyto_cat | included |
| PP2Acyto_PKAcyto_off | included |
| D34nuc_CK2_cat | included |
| Dnuc2cyto_passive | included |
| Dnuc_CK2_off | included |
| photoUncaging_DMNB_cAMP | included |
| Dcyto_PKAcyto_on | included |
| Dnuc_PKAnuc_cat | included |
| D97nuc_PKAnuc_on | included |
| D3497cyto_PP2Bcyto_cyto2nuc | included |
| PP1cyto_D34cyto_PP2Bcyto_on | included |
| D34nuc_PP2Bnuc_on | included |
| R2_PKAcyto_bind | included |
| Dcyto_PKAcyto_off | included |
| D3497cyto_PP2Apcyto_cat | included |
| PP2Anuc_PKAnuc_on | included |
| PP2Bnuc2cyto | included |
| PP2Acyto_PKAcyto_on | included |
| PP1nuc_D3497nuc_PP2Bnuc_on | included |
| R2C_PKAcyto_bind | included |
| PP1cyto_D3497_off | included |
| D3497cyto_PP2Bcyto_cat | included |
| PP1nuc_D34nuc_PP2Bnuc_cat | included |
| PP1nuc_D34nuc_on | included |
| Dcyto_PKAcyto_cat | included |
| PP1cyto_D34cyto_PP2Bcyto_off | included |
| D97cyto_PP2Apcyto_cyto2nuc | included |
| Dnuc_CK2_on | included |
| PP1cyto_D34cyto_cyto2nuc | included |
| D3497nuc_PP2Bnuc_nuc2cyto | included |
| D3497nuc_PP2Apnuc_cat | included |
| D34nuc_PP2Bnuc_cat | included |
| Dcyto2nuc | included |
| cAMPsource2cAMP | included |
| D97nuc_PKAnuc_nuc2cyto | included |
| cAMP_PDE10A_cat | included |
| PP1cyto_D34cyto_off | included |
| PKAnuc2cyto | included |
| D3497nuc_PP2Apnuc_on | included |
| Dnuc_PKAnuc_on | included |
| D34cyto_PP2Bcyto_off | included |
| D3497cyto_PP2Apcyto_off | included |
| PP1cyto2nuc | included |
| D34nuc_CK2_off | included |
| PP1nuc_D34nuc_PP2Bnuc_off | included |
| PP1nuc_D3497nuc_PP2Bnuc_nuc2cyto | included |
| D97cyto_PP2Apcyto_on | included |
| cAMP4_R2_releasecAMP | included |
| PP2Anuc_PKAnuc_nuc2cyto | included |
| D34nuc_PP2Bnuc_off | included |
| D97cyto_PP2Apcyto_cat | included |
| PP1cyto_D3497cyto_PP2Bcyto_cat | included |
| cAMP_R2C2_onoff | included |
| D3497nuc_PP2Bnuc_cat | included |
| D34nuc_CK2_on | included |
| D97nuc_PP2Apnuc_off | included |
| D34cyto_PP2Bcyto_cyto2nuc | included |
| cAMP4_R2C_PKA_onoff | included |
| cAMP_cAMP2_R2C2_onoff | included |
| cAMP4_R2_PKA_onoff | included |
| D97nuc2cyto_passive | included |
| Dcyto_PKAcyto_cyto2nuc | included |
| PP2Apnuc2cyto | included |
| PP2Anuc_PKANuc_off | included |
| PKAcyto2nuc | included |
| PP2Acyto_PKAcyto_cyto2nuc | included |
| PP1cyto_D3497cyto_on | included |
| D97nuc_PP2Apnuc_nuc2cyto | included |
| PP2Apcytodephosphorylation | included |
| PP2Bcyto2nuc | included |
| PP1cyto_D3497cyto_PP2Bcyto_on | included |
| PP1nuc_D34nuc_PP2Bnuc_on | included |
| D97nuc_PP2Apnuc_on | included |
| D34cyto2nuc | included |
| PP2Acyto2nuc | included |
| PP1cyto_D3497cyto_PP2Bcyto_off | included |
| PP1nuc2cyto | included |
| D97cyto2nuc_passive | included |
| cAMP_cAMP_R2C2_onoff | included |
| PP1cyto_D3497cyto_cyto2nuc | included |
| PP1nuc_D3497nuc_nuc2cyto | included |
| D34cyto_PP2Bcyto_cat | included |
| D34cyto_PP2Bcyto_on | included |
| D3497nuc_PP2Bnuc_off | included |
| D3497cyto2nuc_passive | included |
| D34nuc2cyto_passive | included |
| D97cyto_PKAcyto_cyto2nuc | included |
| D3497nuc_PP2Apnuc_off | included |
| PP2Apnucdephosphorylation | included |
| PP1nuc_D3497nuc_on | included |
| D97cyto_PKAcyto_on | included |
| PP1cyto_D34cyto_on | included |
| D97cyto2nuc | included |
| Dnuc_PKAnuc_off | included |
| cAMP_cAMP3_R2C2_onoff | included |
| D3497cyto_PP2Apcyto_cyto2nuc | included |
| D3497nuc_PP2Apnuc_nuc2cyto | included |
| D97cyto_PKAcyto_cat | included |
| D97nuc_PKAnuc_off | included |
| cAMP_PDE10A_onoff | included |
| Name | End Time | Output Options |
|---|---|---|
| cAMPsecondaryMiddle1 | 3600.0 [s] |
OutputTimeStep 5.0 |
| Dimension | Type | Subdomain | Adjacent Subvolumes | Size | Mapped Compartment |
|---|---|---|---|---|---|
| Volume | Analytical | subdomain2 | 301.60068965661543 [um3] | nucleus | |
| Volume | Analytical | subdomain1 | 1202.1930494498022 [um3] | cytosol | |
| Volume | Analytical | subdomain0 | 66696.20626089358 [um3] | c0 | |
| Surface | subdomain0_subdomain1_membrane | subdomain0 | subdomain1 | 1432.4688299433924 [um2] | cellmembrane | |
| Surface | subdomain1_subdomain2_membrane | subdomain1 | subdomain2 | 211.84616618489457 [um2] | nucleusmembrane |
Application - cAMPinput_secondary2
| Species | Initial Condition | Diffusion Constant | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| cAMPsource | (200.0 * ((x >= 77.5) && (x <= 79.3) && (y >= - 7.5) && (y <= - 6.0) && (z >= 5.0) && (z <= 5.5)) * (t < 5.0)) [uM] | 0.0
[um2/s] | D3497cyto |
0.0
[uM]
|
D_d32
[um2/s] | PP1cyto |
5.0
[uM]
|
D_pp1
[um2/s] | PP1cyto_D34cyto |
0.0
[uM]
|
D_d32pp1
[um2/s] | Dcyto |
0.0
[uM]
|
D_d32
[um2/s] | D97cyto_PP2Apcyto |
0.0
[uM]
|
D_d32pp2a
[um2/s] | R2 |
0.0
[uM]
|
D_r2
[um2/s] | PP2Bcyto |
1.6
[uM]
|
D_pp2b
[um2/s] | PP1cyto_D3497cyto_PP2Bcyto |
0.0
[uM]
|
D_d32pp1pp2b
[um2/s] | PDE10A |
1.0
[uM]
|
D_pde10a
[um2/s] | cAMP_PDE10A |
0.0
[uM]
|
D_pde10a
[um2/s] | D97cyto_PKAcyto |
0.0
[uM]
|
D_d32pkac
[um2/s] | PP1cyto_D34cyto_PP2Bcyto |
0.0
[uM]
|
D_d32pp1pp2b
[um2/s] | AMP |
0.0
[uM]
|
0.0
[um2/s] | cAMP |
0.0
[uM]
|
100.0
[um2/s] | DMNB_cAMP |
0.0
[uM]
|
100.0
[um2/s] | light_spot |
0.0
[uM]
|
0.0
[um2/s] | R2C |
0.0
[uM]
|
D_r2c
[um2/s] | cAMP4_R2C2 |
0.0
[uM]
|
D_r2c2
[um2/s] | cAMP4_R2C |
0.0
[uM]
|
D_r2c
[um2/s] | cAMP3_R2C2 |
0.0
[uM]
|
D_r2c2
[um2/s] | cAMP_R2C2 |
0.0
[uM]
|
D_r2c2
[um2/s] | cAMP2_R2C2 |
0.0
[uM]
|
D_r2c2
[um2/s] | D34cyto_PP2Bcyto |
0.0
[uM]
|
D_d32pp2b
[um2/s] | PKAcyto |
0.0
[uM]
|
D_pkac
[um2/s] | D3497cyto_PP2Apcyto |
0.0
[uM]
|
D_d32pp2a
[um2/s] | Dcyto_PKAcyto |
0.0
[uM]
|
D_d32pkac
[um2/s] | PP2Acyto_PKAcyto |
0.0
[uM]
|
D_pp2apka
[um2/s] | PP2Acyto |
2.0
[uM]
|
D_pp2a
[um2/s] | cAMP4_R2 |
0.0
[uM]
|
D_r2
[um2/s] | PP2Apcyto |
0.0
[uM]
|
D_pp2a
[um2/s] | D97cyto |
50.0
[uM]
|
D_d32
[um2/s] | PP1cyto_D3497cyto |
0.0
[uM]
|
D_d32pp1
[um2/s] | D34cyto |
0.0
[uM]
|
D_d32
[um2/s] | R2C2 |
1.0
[uM]
|
D_r2c2
[um2/s] | D3497cyto_PP2Bcyto |
0.0
[uM]
|
D_d32pp2b
[um2/s] | PP2Anuc |
2.0
[uM]
|
D_pp2a
[um2/s] | Dnuc_PKAnuc |
0.0
[uM]
|
D_d32pkac
[um2/s] | D97nuc_PP2Apnuc |
0.0
[uM]
|
D_d32pp2a
[um2/s] | PP1nuc_D34nuc_PP2Bnuc |
0.0
[uM]
|
D_d32pp1pp2b
[um2/s] | D34nuc_CK2 |
0.0
[uM]
|
D_d32ck2
[um2/s] | Dnuc_CK2 |
0.0
[uM]
|
D_d32ck2
[um2/s] | PP2Anuc_PKAnuc |
0.0
[uM]
|
D_pp2apka
[um2/s] | Dnuc |
0.0
[uM]
|
D_d32
[um2/s] | D34nuc_PP2Bnuc |
0.0
[uM]
|
D_d32pp2b
[um2/s] | PP1nuc |
5.0
[uM]
|
D_pp1
[um2/s] | PP1nuc_D34nuc |
0.0
[uM]
|
D_d32pp1
[um2/s] | PP1nuc_D3497nuc |
0.0
[uM]
|
D_d32pp1
[um2/s] | PP1nuc_D3497nuc_PP2Bnuc |
0.0
[uM]
|
D_d32pp1pp2b
[um2/s] | D3497nuc_PP2Apnuc |
0.0
[uM]
|
D_d32pp2a
[um2/s] | D97nuc |
30.0
[uM]
|
D_d32
[um2/s] | D3497nuc_PP2Bnuc |
0.0
[uM]
|
D_d32pp2b
[um2/s] | CK2 |
1.0
[uM]
|
D_ck2
[um2/s] | PP2Apnuc |
0.0
[uM]
|
D_pp2a
[um2/s] | PP2Bnuc |
1.6
[uM]
|
D_pp2b
[um2/s] | D34nuc |
0.0
[uM]
|
D_d32
[um2/s] | D3497nuc |
0.0
[uM]
|
D_d32
[um2/s] | PKAnuc |
0.0
[uM]
|
D_pkac
[um2/s] | D97nuc_PKAnuc |
0.0
[uM]
|
D_d32pkac
[um2/s]
|
|
| Name | Reaction Mapping |
|---|---|
| PP1nuc_D34nuc_off | included |
| D3497cyto_PP2Bcyto_off | included |
| PP1nuc_D3497nuc_off | included |
| PP1cyto_D34cyto_PP2Bcyto_cyto2nuc | included |
| PP2Apcyto2nuc | included |
| D97cyto_PKAcyto_off | included |
| PP1cyto_D3497cyto_PP2Bcyto_cyto2nuc | included |
| D97cyto_PP2Apcyto_off | included |
| D97nuc2cyto | included |
| D3497cyto_PP2Apcyto_on | included |
| Dcyto2nuc_passive | included |
| D34cyto2nuc_passive | included |
| D3497cyto_PP2Bcyto_on | included |
| PP1nuc_D34nuc_nuc2cyto | included |
| Dnuc_CK2_cat | included |
| D3497nuc2cyto | included |
| D97nuc_PKAnuc_cat | included |
| PP2Anuc_PKAnuc_cat | included |
| D97nuc_PP2Apnuc_cat | included |
| PP1nuc_D3497nuc_PP2Bnuc_cat | included |
| PP1nuc_D3497nuc_PP2Bnuc_off | included |
| PP1cyto_D34cyto_PP2Bcyto_cat | included |
| D3497cyto2nuc | included |
| D3497nuc2cyto_passive | included |
| D3497nuc_PP2Bnuc_on | included |
| PP2Anuc2cyto | included |
| PP2Acyto_PKAcyto_cat | included |
| PP2Acyto_PKAcyto_off | included |
| D34nuc_CK2_cat | included |
| Dnuc2cyto_passive | included |
| Dnuc_CK2_off | included |
| photoUncaging_DMNB_cAMP | included |
| Dcyto_PKAcyto_on | included |
| Dnuc_PKAnuc_cat | included |
| D97nuc_PKAnuc_on | included |
| D3497cyto_PP2Bcyto_cyto2nuc | included |
| PP1cyto_D34cyto_PP2Bcyto_on | included |
| D34nuc_PP2Bnuc_on | included |
| R2_PKAcyto_bind | included |
| Dcyto_PKAcyto_off | included |
| D3497cyto_PP2Apcyto_cat | included |
| PP2Anuc_PKAnuc_on | included |
| PP2Bnuc2cyto | included |
| PP2Acyto_PKAcyto_on | included |
| PP1nuc_D3497nuc_PP2Bnuc_on | included |
| R2C_PKAcyto_bind | included |
| PP1cyto_D3497_off | included |
| D3497cyto_PP2Bcyto_cat | included |
| PP1nuc_D34nuc_PP2Bnuc_cat | included |
| PP1nuc_D34nuc_on | included |
| Dcyto_PKAcyto_cat | included |
| PP1cyto_D34cyto_PP2Bcyto_off | included |
| D97cyto_PP2Apcyto_cyto2nuc | included |
| Dnuc_CK2_on | included |
| PP1cyto_D34cyto_cyto2nuc | included |
| D3497nuc_PP2Bnuc_nuc2cyto | included |
| D3497nuc_PP2Apnuc_cat | included |
| D34nuc_PP2Bnuc_cat | included |
| Dcyto2nuc | included |
| cAMPsource2cAMP | included |
| D97nuc_PKAnuc_nuc2cyto | included |
| cAMP_PDE10A_cat | included |
| PP1cyto_D34cyto_off | included |
| PKAnuc2cyto | included |
| D3497nuc_PP2Apnuc_on | included |
| Dnuc_PKAnuc_on | included |
| D34cyto_PP2Bcyto_off | included |
| D3497cyto_PP2Apcyto_off | included |
| PP1cyto2nuc | included |
| D34nuc_CK2_off | included |
| PP1nuc_D34nuc_PP2Bnuc_off | included |
| PP1nuc_D3497nuc_PP2Bnuc_nuc2cyto | included |
| D97cyto_PP2Apcyto_on | included |
| cAMP4_R2_releasecAMP | included |
| PP2Anuc_PKAnuc_nuc2cyto | included |
| D34nuc_PP2Bnuc_off | included |
| D97cyto_PP2Apcyto_cat | included |
| PP1cyto_D3497cyto_PP2Bcyto_cat | included |
| cAMP_R2C2_onoff | included |
| D3497nuc_PP2Bnuc_cat | included |
| D34nuc_CK2_on | included |
| D97nuc_PP2Apnuc_off | included |
| D34cyto_PP2Bcyto_cyto2nuc | included |
| cAMP4_R2C_PKA_onoff | included |
| cAMP_cAMP2_R2C2_onoff | included |
| cAMP4_R2_PKA_onoff | included |
| D97nuc2cyto_passive | included |
| Dcyto_PKAcyto_cyto2nuc | included |
| PP2Apnuc2cyto | included |
| PP2Anuc_PKANuc_off | included |
| PKAcyto2nuc | included |
| PP2Acyto_PKAcyto_cyto2nuc | included |
| PP1cyto_D3497cyto_on | included |
| D97nuc_PP2Apnuc_nuc2cyto | included |
| PP2Apcytodephosphorylation | included |
| PP2Bcyto2nuc | included |
| PP1cyto_D3497cyto_PP2Bcyto_on | included |
| PP1nuc_D34nuc_PP2Bnuc_on | included |
| D97nuc_PP2Apnuc_on | included |
| D34cyto2nuc | included |
| PP2Acyto2nuc | included |
| PP1cyto_D3497cyto_PP2Bcyto_off | included |
| PP1nuc2cyto | included |
| D97cyto2nuc_passive | included |
| cAMP_cAMP_R2C2_onoff | included |
| PP1cyto_D3497cyto_cyto2nuc | included |
| PP1nuc_D3497nuc_nuc2cyto | included |
| D34cyto_PP2Bcyto_cat | included |
| D34cyto_PP2Bcyto_on | included |
| D3497nuc_PP2Bnuc_off | included |
| D3497cyto2nuc_passive | included |
| D34nuc2cyto_passive | included |
| D97cyto_PKAcyto_cyto2nuc | included |
| D3497nuc_PP2Apnuc_off | included |
| PP2Apnucdephosphorylation | included |
| PP1nuc_D3497nuc_on | included |
| D97cyto_PKAcyto_on | included |
| PP1cyto_D34cyto_on | included |
| D97cyto2nuc | included |
| Dnuc_PKAnuc_off | included |
| cAMP_cAMP3_R2C2_onoff | included |
| D3497cyto_PP2Apcyto_cyto2nuc | included |
| D3497nuc_PP2Apnuc_nuc2cyto | included |
| D97cyto_PKAcyto_cat | included |
| D97nuc_PKAnuc_off | included |
| cAMP_PDE10A_onoff | included |
| Name | End Time | Output Options |
|---|---|---|
| cAMPsecondaryMiddle2 | 3600.0 [s] |
OutputTimeStep 5.0 |
| Dimension | Type | Subdomain | Adjacent Subvolumes | Size | Mapped Compartment |
|---|---|---|---|---|---|
| Volume | Analytical | subdomain2 | 301.60068965661543 [um3] | nucleus | |
| Volume | Analytical | subdomain1 | 1202.1930494498022 [um3] | cytosol | |
| Volume | Analytical | subdomain0 | 66696.20626089358 [um3] | c0 | |
| Surface | subdomain0_subdomain1_membrane | subdomain0 | subdomain1 | 1432.4688299433924 [um2] | cellmembrane | |
| Surface | subdomain1_subdomain2_membrane | subdomain1 | subdomain2 | 211.84616618489457 [um2] | nucleusmembrane |
Application - cAMPinput_tertiary1
| Species | Initial Condition | Diffusion Constant | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| cAMPsource | (200.0 * (((x >= 110.5) && (x <= 112.3) && (y >= - 12.0) && (y <= - 10.5) && (z >= 5.0) && (z <= 6.0)) + ((x >= 112.5) && (x <= 112.8) && (y >= - 12.0) && (y <= - 10.5) && (z >= 5.0) && (z <= 5.5))) * (t < 5.0)) [uM] | 0.0
[um2/s] | D3497cyto |
0.0
[uM]
|
D_d32
[um2/s] | PP1cyto |
5.0
[uM]
|
D_pp1
[um2/s] | PP1cyto_D34cyto |
0.0
[uM]
|
D_d32pp1
[um2/s] | Dcyto |
0.0
[uM]
|
D_d32
[um2/s] | D97cyto_PP2Apcyto |
0.0
[uM]
|
D_d32pp2a
[um2/s] | R2 |
0.0
[uM]
|
D_r2
[um2/s] | PP2Bcyto |
1.6
[uM]
|
D_pp2b
[um2/s] | PP1cyto_D3497cyto_PP2Bcyto |
0.0
[uM]
|
D_d32pp1pp2b
[um2/s] | PDE10A |
1.0
[uM]
|
D_pde10a
[um2/s] | cAMP_PDE10A |
0.0
[uM]
|
D_pde10a
[um2/s] | D97cyto_PKAcyto |
0.0
[uM]
|
D_d32pkac
[um2/s] | PP1cyto_D34cyto_PP2Bcyto |
0.0
[uM]
|
D_d32pp1pp2b
[um2/s] | AMP |
0.0
[uM]
|
0.0
[um2/s] | cAMP |
0.0
[uM]
|
100.0
[um2/s] | DMNB_cAMP |
0.0
[uM]
|
100.0
[um2/s] | light_spot |
0.0
[uM]
|
0.0
[um2/s] | R2C |
0.0
[uM]
|
D_r2c
[um2/s] | cAMP4_R2C2 |
0.0
[uM]
|
D_r2c2
[um2/s] | cAMP4_R2C |
0.0
[uM]
|
D_r2c
[um2/s] | cAMP3_R2C2 |
0.0
[uM]
|
D_r2c2
[um2/s] | cAMP_R2C2 |
0.0
[uM]
|
D_r2c2
[um2/s] | cAMP2_R2C2 |
0.0
[uM]
|
D_r2c2
[um2/s] | D34cyto_PP2Bcyto |
0.0
[uM]
|
D_d32pp2b
[um2/s] | PKAcyto |
0.0
[uM]
|
D_pkac
[um2/s] | D3497cyto_PP2Apcyto |
0.0
[uM]
|
D_d32pp2a
[um2/s] | Dcyto_PKAcyto |
0.0
[uM]
|
D_d32pkac
[um2/s] | PP2Acyto_PKAcyto |
0.0
[uM]
|
D_pp2apka
[um2/s] | PP2Acyto |
2.0
[uM]
|
D_pp2a
[um2/s] | cAMP4_R2 |
0.0
[uM]
|
D_r2
[um2/s] | PP2Apcyto |
0.0
[uM]
|
D_pp2a
[um2/s] | D97cyto |
50.0
[uM]
|
D_d32
[um2/s] | PP1cyto_D3497cyto |
0.0
[uM]
|
D_d32pp1
[um2/s] | D34cyto |
0.0
[uM]
|
D_d32
[um2/s] | R2C2 |
1.0
[uM]
|
D_r2c2
[um2/s] | D3497cyto_PP2Bcyto |
0.0
[uM]
|
D_d32pp2b
[um2/s] | PP2Anuc |
2.0
[uM]
|
D_pp2a
[um2/s] | Dnuc_PKAnuc |
0.0
[uM]
|
D_d32pkac
[um2/s] | D97nuc_PP2Apnuc |
0.0
[uM]
|
D_d32pp2a
[um2/s] | PP1nuc_D34nuc_PP2Bnuc |
0.0
[uM]
|
D_d32pp1pp2b
[um2/s] | D34nuc_CK2 |
0.0
[uM]
|
D_d32ck2
[um2/s] | Dnuc_CK2 |
0.0
[uM]
|
D_d32ck2
[um2/s] | PP2Anuc_PKAnuc |
0.0
[uM]
|
D_pp2apka
[um2/s] | Dnuc |
0.0
[uM]
|
D_d32
[um2/s] | D34nuc_PP2Bnuc |
0.0
[uM]
|
D_d32pp2b
[um2/s] | PP1nuc |
5.0
[uM]
|
D_pp1
[um2/s] | PP1nuc_D34nuc |
0.0
[uM]
|
D_d32pp1
[um2/s] | PP1nuc_D3497nuc |
0.0
[uM]
|
D_d32pp1
[um2/s] | PP1nuc_D3497nuc_PP2Bnuc |
0.0
[uM]
|
D_d32pp1pp2b
[um2/s] | D3497nuc_PP2Apnuc |
0.0
[uM]
|
D_d32pp2a
[um2/s] | D97nuc |
30.0
[uM]
|
D_d32
[um2/s] | D3497nuc_PP2Bnuc |
0.0
[uM]
|
D_d32pp2b
[um2/s] | CK2 |
1.0
[uM]
|
D_ck2
[um2/s] | PP2Apnuc |
0.0
[uM]
|
D_pp2a
[um2/s] | PP2Bnuc |
1.6
[uM]
|
D_pp2b
[um2/s] | D34nuc |
0.0
[uM]
|
D_d32
[um2/s] | D3497nuc |
0.0
[uM]
|
D_d32
[um2/s] | PKAnuc |
0.0
[uM]
|
D_pkac
[um2/s] | D97nuc_PKAnuc |
0.0
[uM]
|
D_d32pkac
[um2/s]
|
|
| Name | Reaction Mapping |
|---|---|
| PP1nuc_D34nuc_off | included |
| D3497cyto_PP2Bcyto_off | included |
| PP1nuc_D3497nuc_off | included |
| PP1cyto_D34cyto_PP2Bcyto_cyto2nuc | included |
| PP2Apcyto2nuc | included |
| D97cyto_PKAcyto_off | included |
| PP1cyto_D3497cyto_PP2Bcyto_cyto2nuc | included |
| D97cyto_PP2Apcyto_off | included |
| D97nuc2cyto | included |
| D3497cyto_PP2Apcyto_on | included |
| Dcyto2nuc_passive | included |
| D34cyto2nuc_passive | included |
| D3497cyto_PP2Bcyto_on | included |
| PP1nuc_D34nuc_nuc2cyto | included |
| Dnuc_CK2_cat | included |
| D3497nuc2cyto | included |
| D97nuc_PKAnuc_cat | included |
| PP2Anuc_PKAnuc_cat | included |
| D97nuc_PP2Apnuc_cat | included |
| PP1nuc_D3497nuc_PP2Bnuc_cat | included |
| PP1nuc_D3497nuc_PP2Bnuc_off | included |
| PP1cyto_D34cyto_PP2Bcyto_cat | included |
| D3497cyto2nuc | included |
| D3497nuc2cyto_passive | included |
| D3497nuc_PP2Bnuc_on | included |
| PP2Anuc2cyto | included |
| PP2Acyto_PKAcyto_cat | included |
| PP2Acyto_PKAcyto_off | included |
| D34nuc_CK2_cat | included |
| Dnuc2cyto_passive | included |
| Dnuc_CK2_off | included |
| photoUncaging_DMNB_cAMP | included |
| Dcyto_PKAcyto_on | included |
| Dnuc_PKAnuc_cat | included |
| D97nuc_PKAnuc_on | included |
| D3497cyto_PP2Bcyto_cyto2nuc | included |
| PP1cyto_D34cyto_PP2Bcyto_on | included |
| D34nuc_PP2Bnuc_on | included |
| R2_PKAcyto_bind | included |
| Dcyto_PKAcyto_off | included |
| D3497cyto_PP2Apcyto_cat | included |
| PP2Anuc_PKAnuc_on | included |
| PP2Bnuc2cyto | included |
| PP2Acyto_PKAcyto_on | included |
| PP1nuc_D3497nuc_PP2Bnuc_on | included |
| R2C_PKAcyto_bind | included |
| PP1cyto_D3497_off | included |
| D3497cyto_PP2Bcyto_cat | included |
| PP1nuc_D34nuc_PP2Bnuc_cat | included |
| PP1nuc_D34nuc_on | included |
| Dcyto_PKAcyto_cat | included |
| PP1cyto_D34cyto_PP2Bcyto_off | included |
| D97cyto_PP2Apcyto_cyto2nuc | included |
| Dnuc_CK2_on | included |
| PP1cyto_D34cyto_cyto2nuc | included |
| D3497nuc_PP2Bnuc_nuc2cyto | included |
| D3497nuc_PP2Apnuc_cat | included |
| D34nuc_PP2Bnuc_cat | included |
| Dcyto2nuc | included |
| cAMPsource2cAMP | included |
| D97nuc_PKAnuc_nuc2cyto | included |
| cAMP_PDE10A_cat | included |
| PP1cyto_D34cyto_off | included |
| PKAnuc2cyto | included |
| D3497nuc_PP2Apnuc_on | included |
| Dnuc_PKAnuc_on | included |
| D34cyto_PP2Bcyto_off | included |
| D3497cyto_PP2Apcyto_off | included |
| PP1cyto2nuc | included |
| D34nuc_CK2_off | included |
| PP1nuc_D34nuc_PP2Bnuc_off | included |
| PP1nuc_D3497nuc_PP2Bnuc_nuc2cyto | included |
| D97cyto_PP2Apcyto_on | included |
| cAMP4_R2_releasecAMP | included |
| PP2Anuc_PKAnuc_nuc2cyto | included |
| D34nuc_PP2Bnuc_off | included |
| D97cyto_PP2Apcyto_cat | included |
| PP1cyto_D3497cyto_PP2Bcyto_cat | included |
| cAMP_R2C2_onoff | included |
| D3497nuc_PP2Bnuc_cat | included |
| D34nuc_CK2_on | included |
| D97nuc_PP2Apnuc_off | included |
| D34cyto_PP2Bcyto_cyto2nuc | included |
| cAMP4_R2C_PKA_onoff | included |
| cAMP_cAMP2_R2C2_onoff | included |
| cAMP4_R2_PKA_onoff | included |
| D97nuc2cyto_passive | included |
| Dcyto_PKAcyto_cyto2nuc | included |
| PP2Apnuc2cyto | included |
| PP2Anuc_PKANuc_off | included |
| PKAcyto2nuc | included |
| PP2Acyto_PKAcyto_cyto2nuc | included |
| PP1cyto_D3497cyto_on | included |
| D97nuc_PP2Apnuc_nuc2cyto | included |
| PP2Apcytodephosphorylation | included |
| PP2Bcyto2nuc | included |
| PP1cyto_D3497cyto_PP2Bcyto_on | included |
| PP1nuc_D34nuc_PP2Bnuc_on | included |
| D97nuc_PP2Apnuc_on | included |
| D34cyto2nuc | included |
| PP2Acyto2nuc | included |
| PP1cyto_D3497cyto_PP2Bcyto_off | included |
| PP1nuc2cyto | included |
| D97cyto2nuc_passive | included |
| cAMP_cAMP_R2C2_onoff | included |
| PP1cyto_D3497cyto_cyto2nuc | included |
| PP1nuc_D3497nuc_nuc2cyto | included |
| D34cyto_PP2Bcyto_cat | included |
| D34cyto_PP2Bcyto_on | included |
| D3497nuc_PP2Bnuc_off | included |
| D3497cyto2nuc_passive | included |
| D34nuc2cyto_passive | included |
| D97cyto_PKAcyto_cyto2nuc | included |
| D3497nuc_PP2Apnuc_off | included |
| PP2Apnucdephosphorylation | included |
| PP1nuc_D3497nuc_on | included |
| D97cyto_PKAcyto_on | included |
| PP1cyto_D34cyto_on | included |
| D97cyto2nuc | included |
| Dnuc_PKAnuc_off | included |
| cAMP_cAMP3_R2C2_onoff | included |
| D3497cyto_PP2Apcyto_cyto2nuc | included |
| D3497nuc_PP2Apnuc_nuc2cyto | included |
| D97cyto_PKAcyto_cat | included |
| D97nuc_PKAnuc_off | included |
| cAMP_PDE10A_onoff | included |
| Name | End Time | Output Options |
|---|---|---|
| cAMPtertiaryMiddle1 | 3600.0 [s] |
OutputTimeStep 5.0 |
| Dimension | Type | Subdomain | Adjacent Subvolumes | Size | Mapped Compartment |
|---|---|---|---|---|---|
| Volume | Analytical | subdomain2 | 301.60068965661543 [um3] | nucleus | |
| Volume | Analytical | subdomain1 | 1202.1930494498022 [um3] | cytosol | |
| Volume | Analytical | subdomain0 | 66696.20626089358 [um3] | c0 | |
| Surface | subdomain0_subdomain1_membrane | subdomain0 | subdomain1 | 1432.4688299433924 [um2] | cellmembrane | |
| Surface | subdomain1_subdomain2_membrane | subdomain1 | subdomain2 | 211.84616618489457 [um2] | nucleusmembrane |
Application - cAMPinput_tertiary2
| Species | Initial Condition | Diffusion Constant | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| cAMPsource | (200.0 * (((x >= 130.5) && (x <= 132.3) && (y >= - 12.0) && (y <= - 10.5) && (z >= 5.0) && (z <= 6.0)) + ((x >= 132.5) && (x <= 132.8) && (y >= - 12.0) && (y <= - 10.5) && (z >= 5.0) && (z <= 5.5))) * (t < 5.0)) [uM] | 0.0
[um2/s] | D3497cyto |
0.0
[uM]
|
D_d32
[um2/s] | PP1cyto |
5.0
[uM]
|
D_pp1
[um2/s] | PP1cyto_D34cyto |
0.0
[uM]
|
D_d32pp1
[um2/s] | Dcyto |
0.0
[uM]
|
D_d32
[um2/s] | D97cyto_PP2Apcyto |
0.0
[uM]
|
D_d32pp2a
[um2/s] | R2 |
0.0
[uM]
|
D_r2
[um2/s] | PP2Bcyto |
1.6
[uM]
|
D_pp2b
[um2/s] | PP1cyto_D3497cyto_PP2Bcyto |
0.0
[uM]
|
D_d32pp1pp2b
[um2/s] | PDE10A |
1.0
[uM]
|
D_pde10a
[um2/s] | cAMP_PDE10A |
0.0
[uM]
|
D_pde10a
[um2/s] | D97cyto_PKAcyto |
0.0
[uM]
|
D_d32pkac
[um2/s] | PP1cyto_D34cyto_PP2Bcyto |
0.0
[uM]
|
D_d32pp1pp2b
[um2/s] | AMP |
0.0
[uM]
|
0.0
[um2/s] | cAMP |
0.0
[uM]
|
100.0
[um2/s] | DMNB_cAMP |
0.0
[uM]
|
100.0
[um2/s] | light_spot |
0.0
[uM]
|
0.0
[um2/s] | R2C |
0.0
[uM]
|
D_r2c
[um2/s] | cAMP4_R2C2 |
0.0
[uM]
|
D_r2c2
[um2/s] | cAMP4_R2C |
0.0
[uM]
|
D_r2c
[um2/s] | cAMP3_R2C2 |
0.0
[uM]
|
D_r2c2
[um2/s] | cAMP_R2C2 |
0.0
[uM]
|
D_r2c2
[um2/s] | cAMP2_R2C2 |
0.0
[uM]
|
D_r2c2
[um2/s] | D34cyto_PP2Bcyto |
0.0
[uM]
|
D_d32pp2b
[um2/s] | PKAcyto |
0.0
[uM]
|
D_pkac
[um2/s] | D3497cyto_PP2Apcyto |
0.0
[uM]
|
D_d32pp2a
[um2/s] | Dcyto_PKAcyto |
0.0
[uM]
|
D_d32pkac
[um2/s] | PP2Acyto_PKAcyto |
0.0
[uM]
|
D_pp2apka
[um2/s] | PP2Acyto |
2.0
[uM]
|
D_pp2a
[um2/s] | cAMP4_R2 |
0.0
[uM]
|
D_r2
[um2/s] | PP2Apcyto |
0.0
[uM]
|
D_pp2a
[um2/s] | D97cyto |
50.0
[uM]
|
D_d32
[um2/s] | PP1cyto_D3497cyto |
0.0
[uM]
|
D_d32pp1
[um2/s] | D34cyto |
0.0
[uM]
|
D_d32
[um2/s] | R2C2 |
1.0
[uM]
|
D_r2c2
[um2/s] | D3497cyto_PP2Bcyto |
0.0
[uM]
|
D_d32pp2b
[um2/s] | PP2Anuc |
2.0
[uM]
|
D_pp2a
[um2/s] | Dnuc_PKAnuc |
0.0
[uM]
|
D_d32pkac
[um2/s] | D97nuc_PP2Apnuc |
0.0
[uM]
|
D_d32pp2a
[um2/s] | PP1nuc_D34nuc_PP2Bnuc |
0.0
[uM]
|
D_d32pp1pp2b
[um2/s] | D34nuc_CK2 |
0.0
[uM]
|
D_d32ck2
[um2/s] | Dnuc_CK2 |
0.0
[uM]
|
D_d32ck2
[um2/s] | PP2Anuc_PKAnuc |
0.0
[uM]
|
D_pp2apka
[um2/s] | Dnuc |
0.0
[uM]
|
D_d32
[um2/s] | D34nuc_PP2Bnuc |
0.0
[uM]
|
D_d32pp2b
[um2/s] | PP1nuc |
5.0
[uM]
|
D_pp1
[um2/s] | PP1nuc_D34nuc |
0.0
[uM]
|
D_d32pp1
[um2/s] | PP1nuc_D3497nuc |
0.0
[uM]
|
D_d32pp1
[um2/s] | PP1nuc_D3497nuc_PP2Bnuc |
0.0
[uM]
|
D_d32pp1pp2b
[um2/s] | D3497nuc_PP2Apnuc |
0.0
[uM]
|
D_d32pp2a
[um2/s] | D97nuc |
30.0
[uM]
|
D_d32
[um2/s] | D3497nuc_PP2Bnuc |
0.0
[uM]
|
D_d32pp2b
[um2/s] | CK2 |
1.0
[uM]
|
D_ck2
[um2/s] | PP2Apnuc |
0.0
[uM]
|
D_pp2a
[um2/s] | PP2Bnuc |
1.6
[uM]
|
D_pp2b
[um2/s] | D34nuc |
0.0
[uM]
|
D_d32
[um2/s] | D3497nuc |
0.0
[uM]
|
D_d32
[um2/s] | PKAnuc |
0.0
[uM]
|
D_pkac
[um2/s] | D97nuc_PKAnuc |
0.0
[uM]
|
D_d32pkac
[um2/s]
|
|
| Name | Reaction Mapping |
|---|---|
| PP1nuc_D34nuc_off | included |
| D3497cyto_PP2Bcyto_off | included |
| PP1nuc_D3497nuc_off | included |
| PP1cyto_D34cyto_PP2Bcyto_cyto2nuc | included |
| PP2Apcyto2nuc | included |
| D97cyto_PKAcyto_off | included |
| PP1cyto_D3497cyto_PP2Bcyto_cyto2nuc | included |
| D97cyto_PP2Apcyto_off | included |
| D97nuc2cyto | included |
| D3497cyto_PP2Apcyto_on | included |
| Dcyto2nuc_passive | included |
| D34cyto2nuc_passive | included |
| D3497cyto_PP2Bcyto_on | included |
| PP1nuc_D34nuc_nuc2cyto | included |
| Dnuc_CK2_cat | included |
| D3497nuc2cyto | included |
| D97nuc_PKAnuc_cat | included |
| PP2Anuc_PKAnuc_cat | included |
| D97nuc_PP2Apnuc_cat | included |
| PP1nuc_D3497nuc_PP2Bnuc_cat | included |
| PP1nuc_D3497nuc_PP2Bnuc_off | included |
| PP1cyto_D34cyto_PP2Bcyto_cat | included |
| D3497cyto2nuc | included |
| D3497nuc2cyto_passive | included |
| D3497nuc_PP2Bnuc_on | included |
| PP2Anuc2cyto | included |
| PP2Acyto_PKAcyto_cat | included |
| PP2Acyto_PKAcyto_off | included |
| D34nuc_CK2_cat | included |
| Dnuc2cyto_passive | included |
| Dnuc_CK2_off | included |
| photoUncaging_DMNB_cAMP | included |
| Dcyto_PKAcyto_on | included |
| Dnuc_PKAnuc_cat | included |
| D97nuc_PKAnuc_on | included |
| D3497cyto_PP2Bcyto_cyto2nuc | included |
| PP1cyto_D34cyto_PP2Bcyto_on | included |
| D34nuc_PP2Bnuc_on | included |
| R2_PKAcyto_bind | included |
| Dcyto_PKAcyto_off | included |
| D3497cyto_PP2Apcyto_cat | included |
| PP2Anuc_PKAnuc_on | included |
| PP2Bnuc2cyto | included |
| PP2Acyto_PKAcyto_on | included |
| PP1nuc_D3497nuc_PP2Bnuc_on | included |
| R2C_PKAcyto_bind | included |
| PP1cyto_D3497_off | included |
| D3497cyto_PP2Bcyto_cat | included |
| PP1nuc_D34nuc_PP2Bnuc_cat | included |
| PP1nuc_D34nuc_on | included |
| Dcyto_PKAcyto_cat | included |
| PP1cyto_D34cyto_PP2Bcyto_off | included |
| D97cyto_PP2Apcyto_cyto2nuc | included |
| Dnuc_CK2_on | included |
| PP1cyto_D34cyto_cyto2nuc | included |
| D3497nuc_PP2Bnuc_nuc2cyto | included |
| D3497nuc_PP2Apnuc_cat | included |
| D34nuc_PP2Bnuc_cat | included |
| Dcyto2nuc | included |
| cAMPsource2cAMP | included |
| D97nuc_PKAnuc_nuc2cyto | included |
| cAMP_PDE10A_cat | included |
| PP1cyto_D34cyto_off | included |
| PKAnuc2cyto | included |
| D3497nuc_PP2Apnuc_on | included |
| Dnuc_PKAnuc_on | included |
| D34cyto_PP2Bcyto_off | included |
| D3497cyto_PP2Apcyto_off | included |
| PP1cyto2nuc | included |
| D34nuc_CK2_off | included |
| PP1nuc_D34nuc_PP2Bnuc_off | included |
| PP1nuc_D3497nuc_PP2Bnuc_nuc2cyto | included |
| D97cyto_PP2Apcyto_on | included |
| cAMP4_R2_releasecAMP | included |
| PP2Anuc_PKAnuc_nuc2cyto | included |
| D34nuc_PP2Bnuc_off | included |
| D97cyto_PP2Apcyto_cat | included |
| PP1cyto_D3497cyto_PP2Bcyto_cat | included |
| cAMP_R2C2_onoff | included |
| D3497nuc_PP2Bnuc_cat | included |
| D34nuc_CK2_on | included |
| D97nuc_PP2Apnuc_off | included |
| D34cyto_PP2Bcyto_cyto2nuc | included |
| cAMP4_R2C_PKA_onoff | included |
| cAMP_cAMP2_R2C2_onoff | included |
| cAMP4_R2_PKA_onoff | included |
| D97nuc2cyto_passive | included |
| Dcyto_PKAcyto_cyto2nuc | included |
| PP2Apnuc2cyto | included |
| PP2Anuc_PKANuc_off | included |
| PKAcyto2nuc | included |
| PP2Acyto_PKAcyto_cyto2nuc | included |
| PP1cyto_D3497cyto_on | included |
| D97nuc_PP2Apnuc_nuc2cyto | included |
| PP2Apcytodephosphorylation | included |
| PP2Bcyto2nuc | included |
| PP1cyto_D3497cyto_PP2Bcyto_on | included |
| PP1nuc_D34nuc_PP2Bnuc_on | included |
| D97nuc_PP2Apnuc_on | included |
| D34cyto2nuc | included |
| PP2Acyto2nuc | included |
| PP1cyto_D3497cyto_PP2Bcyto_off | included |
| PP1nuc2cyto | included |
| D97cyto2nuc_passive | included |
| cAMP_cAMP_R2C2_onoff | included |
| PP1cyto_D3497cyto_cyto2nuc | included |
| PP1nuc_D3497nuc_nuc2cyto | included |
| D34cyto_PP2Bcyto_cat | included |
| D34cyto_PP2Bcyto_on | included |
| D3497nuc_PP2Bnuc_off | included |
| D3497cyto2nuc_passive | included |
| D34nuc2cyto_passive | included |
| D97cyto_PKAcyto_cyto2nuc | included |
| D3497nuc_PP2Apnuc_off | included |
| PP2Apnucdephosphorylation | included |
| PP1nuc_D3497nuc_on | included |
| D97cyto_PKAcyto_on | included |
| PP1cyto_D34cyto_on | included |
| D97cyto2nuc | included |
| Dnuc_PKAnuc_off | included |
| cAMP_cAMP3_R2C2_onoff | included |
| D3497cyto_PP2Apcyto_cyto2nuc | included |
| D3497nuc_PP2Apnuc_nuc2cyto | included |
| D97cyto_PKAcyto_cat | included |
| D97nuc_PKAnuc_off | included |
| cAMP_PDE10A_onoff | included |
| Name | End Time | Output Options |
|---|---|---|
| cAMPtertiaryMiddle2 | 3600.0 [s] |
OutputTimeStep 5.0 |
| Dimension | Type | Subdomain | Adjacent Subvolumes | Size | Mapped Compartment |
|---|---|---|---|---|---|
| Volume | Analytical | subdomain2 | 301.60068965661543 [um3] | nucleus | |
| Volume | Analytical | subdomain1 | 1202.1930494498022 [um3] | cytosol | |
| Volume | Analytical | subdomain0 | 66696.20626089358 [um3] | c0 | |
| Surface | subdomain0_subdomain1_membrane | subdomain0 | subdomain1 | 1432.4688299433924 [um2] | cellmembrane | |
| Surface | subdomain1_subdomain2_membrane | subdomain1 | subdomain2 | 211.84616618489457 [um2] | nucleusmembrane |
Global Parameters
| Name | Expression |
|---|---|
| D_PKA_kon | 5.6[uM-1.s-1] |
|
|
|
| D_PKA_koff | 10.8[s-1] |
|
|
|
| D_PKA_kcat | 2.7[s-1] |
|
|
|
| D34_PP2B_kon | 4.1[uM-1.s-1] |
|
|
|
| D34_PP2B_koff | 6.4[s-1] |
|
|
|
| D34_PP2B_kcat | 0.1[s-1] |
|
|
|
| D_CK2_kon | 3.0[uM-1.s-1] |
|
|
|
| D_CK2_koff | 10.0[s-1] |
|
|
|
| D_CK2_kcat | 0.32[s-1] |
|
|
|
| D97_PP2Ap_kon | 2.7[uM-1.s-1] |
|
|
|
| D97_PP2Ap_koff | 4.45[s-1] |
|
|
|
| D97_PP2Ap_kcat | 0.2[s-1] |
|
|
|
| PP1_D34_kon | 40.0[uM-1.s-1] |
|
|
|
| PP1_D34_koff | 0.4[s-1] |
|
|
|
| kD97nuc2cyto | 133.6313[molecules.um-2.uM-1.s-1] |
|
|
|
| kDcyto2nuc | 80.0[molecules.um-2.uM-1.s-1] |
|
|
|
| kfastnuc2cyto | 0.7[tbd] |
|
|
|
| kfastcyto2nuc | 0.7[tbd] |
|
|
|
| PP2A_PKA_kon | 2.4[uM-1.s-1] |
|
|
|
| PP2A_PKA_koff | 0.1[s-1] |
|
|
|
| PP2A_PKA_kcat | 0.3[s-1] |
|
|
|
| gDnuctotal | (Dnuc + D34nuc + D97nuc + D3497nuc + Dnuc_PKAnuc + D97nuc_PKAnuc + D34nuc_PP2Bnuc + D3497nuc_PP2Bnuc + D97nuc_PP2Apnuc + D3497nuc_PP2Apnuc + Dnuc_CK2 + D34nuc_CK2 + PP1nuc_D34nuc + PP1nuc_D3497nuc + PP1nuc_D34nuc_PP2Bnuc + PP1nuc_D3497nuc_PP2Bnuc)[uM] |
|
|
|
| gDcytototal | (Dcyto + D34cyto + D97cyto + D3497cyto + Dcyto_PKAcyto + D97cyto_PKAcyto + D34cyto_PP2Bcyto + D3497cyto_PP2Bcyto + D97cyto_PP2Apcyto + D3497cyto_PP2Apcyto + PP1cyto_D34cyto + PP1cyto_D3497cyto + PP1cyto_D34cyto_PP2Bcyto + PP1cyto_D3497cyto_PP2Bcyto)[uM] |
|
|
|
| gD34total | (D34cyto + D34nuc + D3497cyto + D3497nuc + D34cyto_PP2Bcyto + D34nuc_PP2Bnuc + D3497cyto_PP2Bcyto + D3497nuc_PP2Bnuc + D3497cyto_PP2Apcyto + D3497nuc_PP2Apnuc + D34nuc_CK2 + PP1nuc_D34nuc + PP1nuc_D3497nuc + PP1cyto_D34cyto + PP1cyto_D3497cyto + PP1cyto_D34cyto_PP2Bcyto + PP1cyto_D3497cyto_PP2Bcyto + PP1nuc_D34nuc_PP2Bnuc + PP1nuc_D3497nuc_PP2Bnuc)[uM] |
|
|
|
| gD34nuctotal | (D34nuc + D3497nuc + D34nuc_PP2Bnuc + D3497nuc_PP2Bnuc + D3497nuc_PP2Apnuc + D34nuc_CK2 + PP1nuc_D34nuc + PP1nuc_D3497nuc + PP1nuc_D34nuc_PP2Bnuc + PP1nuc_D3497nuc_PP2Bnuc)[uM] |
|
|
|
| gD34cytototal | (D34cyto + D3497cyto + D34cyto_PP2Bcyto + D3497cyto_PP2Bcyto + D3497cyto_PP2Apcyto + PP1cyto_D34cyto + PP1cyto_D3497cyto + PP1cyto_D34cyto_PP2Bcyto + PP1cyto_D3497cyto_PP2Bcyto)[uM] |
|
|
|
| gD97total | (D97cyto + D97nuc + D3497cyto + D3497nuc + D97cyto_PKAcyto + D97nuc_PKAnuc + D3497cyto_PP2Bcyto + D3497nuc_PP2Bnuc + D97cyto_PP2Apcyto + D97nuc_PP2Apnuc + D3497cyto_PP2Apcyto + D3497nuc_PP2Apnuc + PP1nuc_D3497nuc + PP1cyto_D3497cyto + PP1cyto_D3497cyto_PP2Bcyto + PP1nuc_D3497nuc_PP2Bnuc)[uM] |
|
|
|
| gD97nuctotal | (D97nuc + D3497nuc + D97nuc_PKAnuc + D3497nuc_PP2Bnuc + D97nuc_PP2Apnuc + D3497nuc_PP2Apnuc + PP1nuc_D3497nuc + PP1nuc_D3497nuc_PP2Bnuc)[uM] |
|
|
|
| gD97cytototal | (D97cyto + D3497cyto + D97cyto_PKAcyto + D3497cyto_PP2Bcyto + D97cyto_PP2Apcyto + D3497cyto_PP2Apcyto + PP1cyto_D3497cyto + PP1cyto_D3497cyto_PP2Bcyto)[uM] |
|
|
|
| gDncratio | ((Dnuc + D34nuc + D97nuc + D3497nuc + Dnuc_PKAnuc + D97nuc_PKAnuc + D34nuc_PP2Bnuc + D3497nuc_PP2Bnuc + D97nuc_PP2Apnuc + D3497nuc_PP2Apnuc + Dnuc_CK2 + D34nuc_CK2 + PP1nuc_D34nuc + PP1nuc_D3497nuc + PP1nuc_D34nuc_PP2Bnuc + PP1nuc_D3497nuc_PP2Bnuc) / (Dcyto + D34cyto + D97cyto + D3497cyto + Dcyto_PKAcyto + D97cyto_PKAcyto + D34cyto_PP2Bcyto + D3497cyto_PP2Bcyto + D97cyto_PP2Apcyto + D3497cyto_PP2Apcyto + PP1cyto_D34cyto + PP1cyto_D3497cyto + PP1cyto_D34cyto_PP2Bcyto + PP1cyto_D3497cyto_PP2Bcyto))[tbd] |
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| gPP1itotal | (PP1nuc_D3497nuc + PP1nuc_D34nuc + PP1cyto_D34cyto + PP1cyto_D3497cyto + PP1cyto_D34cyto_PP2Bcyto + PP1cyto_D3497cyto_PP2Bcyto + PP1nuc_D34nuc_PP2Bnuc + PP1nuc_D3497nuc_PP2Bnuc)[uM] |
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| gPP1ibar | (0.625 * (PP1nuc_D3497nuc + PP1nuc_D34nuc + PP1cyto_D34cyto + PP1cyto_D3497cyto + PP1cyto_D34cyto_PP2Bcyto + PP1cyto_D3497cyto_PP2Bcyto + PP1nuc_D34nuc_PP2Bnuc + PP1nuc_D3497nuc_PP2Bnuc)) [tbd] |
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| gPKAtotal | (PKAcyto + PKAnuc + PP2Acyto_PKAcyto + PP2Anuc_PKAnuc + Dcyto_PKAcyto + Dnuc_PKAnuc + D97cyto_PKAcyto + D97nuc_PKAnuc)[uM] |
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| gPKAnuctotal | (PKAnuc + PP2Anuc_PKAnuc + Dnuc_PKAnuc + D97nuc_PKAnuc)[uM] |
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| gPKAcytototal | (PKAcyto + PP2Acyto_PKAcyto + Dcyto_PKAcyto + D97cyto_PKAcyto)[uM] |
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| gPP2Acytototal | (D3497cyto_PP2Apcyto + D97cyto_PP2Apcyto + PP2Acyto + PP2Acyto_PKAcyto + PP2Apcyto)[uM] |
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| gPP2Anuctotal | (D3497nuc_PP2Apnuc + D97nuc_PP2Apnuc + PP2Anuc + PP2Anuc_PKAnuc + PP2Apnuc)[uM] |
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| D_d32 | 7.0[um2.s-1] |
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| D_pp2a | 3.6[um2.s-1] |
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| D_pp2b | 4.7[um2.s-1] |
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| D_pkac | 4.4[um2.s-1] |
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| D_d32pkac | 3.8[um2.s-1] |
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| D_d32pp2a | 3.4[um2.s-1] |
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| D_d32pp2b | 4.3[um2.s-1] |
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| D_r2c2 | 2.7[um2.s-1] |
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| D_r2c | 3.0[um2.s-1] |
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| D_r2 | 3.3[um2.s-1] |
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| D_ck2 | 5.0[um2.s-1] |
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| D_d32ck2 | 4.6[um2.s-1] |
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| D_pp1 | 4.6[um2.s-1] |
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| D_d32pp1 | 4.3[um2.s-1] |
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| D_pp2apka | 2.5[um2.s-1] |
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| D_d32pp1pp2b | 3.5[um2.s-1] |
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| D_rc | 3.4[um2.s-1] |
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| D_r | 4.1[um2.s-1] |
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| cAMP_PDE10A_kon | 80.0[uM-1.s-1] |
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| cAMP_PDE10A_koff | 16.8[s-1] |
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| cAMP_PDE10A_kcat | 0.5[s-1] |
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| kDcyto2nuc_passive | 1.62[molecules.um-2.uM-1.s-1] |
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| kDnuc2cyto_passive | 1.62[molecules.um-2.uM-1.s-1] |
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| D_pde10a | 5.0[um2.s-1] |
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| gcAMPboundR2 | (cAMP_R2C2 + cAMP2_R2C2 + cAMP3_R2C2 + cAMP4_R2C2 + cAMP4_R2C + cAMP4_R2)[uM] |
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| cAMP_R2C2_kon | 54.0[uM-1.s-1] |
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| cAMP_R2C2_koff | 3.0[s-1] |
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| cAMP_cAMPR2C2_kon | 54.0[uM-1.s-1] |
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| cAMP_cAMPR2C2_koff | 3.0[s-1] |
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| cAMP_cAMP2R2C2_kon | 75.0[uM-1.s-1] |
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| cAMP_cAMP2R2C2_koff | 110.0[s-1] |
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| cAMP_cAMP3R2C2_kon | 75.0[uM-1.s-1] |
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| cAMP_cAMP3R2C2_koff | 110.0[s-1] |
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| cAMP4R2C_PKA_kon | 18.0[uM-1.s-1] |
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| cAMP4R2C_PKA_koff | 0.1[s-1] |
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| cAMP4R2_PKA_kon | 18.0[uM-1.s-1] |
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| cAMP4R2_PKA_koff | 0.1[s-1] |
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| kPKAcyto2nuc_passive | 2.73[molecules.um-2.uM-1.s-1] |
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| kPKAnuc2cyto_passive | 2.73[molecules.um-2.uM-1.s-1] |
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