Physiology
Reaction Diagram
Cross-References
Annotations
Reactions
| Reactions | Name | Structure | Kinetics | Depiction |
|---|---|---|---|---|
| PP1nuc_D34nucPP1nuc+D34nuc | PP1nuc_D34nuc_off | nucleus | MassAction | |
| D3497cyto_PP2BcytoD3497cyto+PP2Bcyto | D3497cyto_PP2Bcyto_off | cytosol | MassAction | |
| PP1nuc_D3497nucPP1nuc+D3497nuc | PP1nuc_D3497nuc_off | nucleus | MassAction | |
| PP1cyto_D34cyto_PP2BcytoPP1nuc_D34nuc_PP2Bnuc | PP1cyto_D34cyto_PP2Bcyto_cyto2nuc | nucleusmembrane | MassAction | |
| PP2ApcytoPP2Apnuc | PP2Apcyto2nuc | nucleusmembrane | MassAction | |
| D97cyto_PKAcytoPKAcyto+D97cyto | D97cyto_PKAcyto_off | cytosol | MassAction | |
| PP1cyto_D3497cyto_PP2BcytoPP1nuc_D3497nuc_PP2Bnuc | PP1cyto_D3497cyto_PP2Bcyto_cyto2nuc | nucleusmembrane | MassAction | |
| D97cyto_PP2ApcytoPP2Apcyto+D97cyto | D97cyto_PP2Apcyto_off | cytosol | MassAction | |
| D97nucD97cyto | D97nuc2cyto | nucleusmembrane | MassAction | |
| D3497cyto+PP2ApcytoD3497cyto_PP2Apcyto | D3497cyto_PP2Apcyto_on | cytosol | MassAction | |
| DcytoDnuc | Dcyto2nuc_passive | nucleusmembrane | MassAction | |
| D34cytoD34nuc | D34cyto2nuc_passive | nucleusmembrane | MassAction | |
| PP2Bcyto+D3497cytoD3497cyto_PP2Bcyto | D3497cyto_PP2Bcyto_on | cytosol | MassAction | |
| PP1nuc_D34nucPP1cyto_D34cyto | PP1nuc_D34nuc_nuc2cyto | nucleusmembrane | MassAction | |
| Dnuc_CK2D97nuc+CK2 | Dnuc_CK2_cat | nucleus | MassAction | |
| D3497nucD3497cyto | D3497nuc2cyto | nucleusmembrane | MassAction | |
| D97nuc_PKAnucD3497nuc+PKAnuc | D97nuc_PKAnuc_cat | nucleus | MassAction | |
| PP2Anuc_PKAnucPP2Apnuc+PKAnuc | PP2Anuc_PKAnuc_cat | nucleus | MassAction | |
| D97nuc_PP2ApnucPP2Apnuc+Dnuc | D97nuc_PP2Apnuc_cat | nucleus | MassAction | |
| PP1nuc_D3497nuc_PP2BnucPP2Bnuc+PP1nuc+D97nuc | PP1nuc_D3497nuc_PP2Bnuc_cat | nucleus | MassAction | |
| PP1nuc_D3497nuc_PP2BnucPP1nuc_D3497nuc+PP2Bnuc | PP1nuc_D3497nuc_PP2Bnuc_off | nucleus | MassAction | |
| PP1cyto_D34cyto_PP2BcytoDcyto+PP2Bcyto+PP1cyto | PP1cyto_D34cyto_PP2Bcyto_cat | cytosol | MassAction | |
| D3497cytoD3497nuc | D3497cyto2nuc | nucleusmembrane | MassAction | |
| D3497nucD3497cyto | D3497nuc2cyto_passive | nucleusmembrane | MassAction | |
| D3497nuc+PP2BnucD3497nuc_PP2Bnuc | D3497nuc_PP2Bnuc_on | nucleus | MassAction | |
| PP2AnucPP2Acyto | PP2Anuc2cyto | nucleusmembrane | MassAction | |
| PP2Acyto_PKAcytoPKAcyto+PP2Apcyto | PP2Acyto_PKAcyto_cat | cytosol | MassAction | |
| PP2Acyto_PKAcytoPKAcyto+PP2Acyto | PP2Acyto_PKAcyto_off | cytosol | MassAction | |
| D34nuc_CK2CK2+D3497nuc | D34nuc_CK2_cat | nucleus | MassAction | |
| DnucDcyto | Dnuc2cyto_passive | nucleusmembrane | MassAction | |
| Dnuc_CK2Dnuc+CK2 | Dnuc_CK2_off | nucleus | MassAction | |
| DMNB_cAMPcAMP | photoUncaging_DMNB_cAMP | cytosol | GeneralKinetics | |
| Dcyto+PKAcytoDcyto_PKAcyto | Dcyto_PKAcyto_on | cytosol | MassAction | |
| Dnuc_PKAnucD34nuc+PKAnuc | Dnuc_PKAnuc_cat | nucleus | MassAction | |
| D97nuc+PKAnucD97nuc_PKAnuc | D97nuc_PKAnuc_on | nucleus | MassAction | |
| D3497cyto_PP2BcytoD3497nuc_PP2Bnuc | D3497cyto_PP2Bcyto_cyto2nuc | nucleusmembrane | MassAction | |
| PP2Bcyto+PP1cyto_D34cytoPP1cyto_D34cyto_PP2Bcyto | PP1cyto_D34cyto_PP2Bcyto_on | cytosol | MassAction | |
| D34nuc+PP2BnucD34nuc_PP2Bnuc | D34nuc_PP2Bnuc_on | nucleus | MassAction | |
| R2+PKAcytoR2C | R2_PKAcyto_bind | cytosol | MassAction | |
| Dcyto_PKAcytoPKAcyto+Dcyto | Dcyto_PKAcyto_off | cytosol | MassAction | |
| D3497cyto_PP2ApcytoD34cyto+PP2Apcyto | D3497cyto_PP2Apcyto_cat | cytosol | MassAction | |
| PP2Anuc+PKAnucPP2Anuc_PKAnuc | PP2Anuc_PKAnuc_on | nucleus | MassAction | |
| PP2BnucPP2Bcyto | PP2Bnuc2cyto | nucleusmembrane | MassAction | |
| PP2Acyto+PKAcytoPP2Acyto_PKAcyto | PP2Acyto_PKAcyto_on | cytosol | MassAction | |
| PP2Bnuc+PP1nuc_D3497nucPP1nuc_D3497nuc_PP2Bnuc | PP1nuc_D3497nuc_PP2Bnuc_on | nucleus | MassAction | |
| R2C+PKAcytoR2C2 | R2C_PKAcyto_bind | cytosol | MassAction | |
| PP1cyto_D3497cytoPP1cyto+D3497cyto | PP1cyto_D3497_off | cytosol | MassAction | |
| D3497cyto_PP2BcytoD97cyto+PP2Bcyto | D3497cyto_PP2Bcyto_cat | cytosol | MassAction | |
| PP1nuc_D34nuc_PP2BnucPP1nuc+Dnuc+PP2Bnuc | PP1nuc_D34nuc_PP2Bnuc_cat | nucleus | MassAction | |
| D34nuc+PP1nucPP1nuc_D34nuc | PP1nuc_D34nuc_on | nucleus | MassAction | |
| Dcyto_PKAcytoPKAcyto+D34cyto | Dcyto_PKAcyto_cat | cytosol | MassAction | |
| PP1cyto_D34cyto_PP2BcytoPP2Bcyto+PP1cyto_D34cyto | PP1cyto_D34cyto_PP2Bcyto_off | cytosol | MassAction | |
| D97cyto_PP2ApcytoD97nuc_PP2Apnuc | D97cyto_PP2Apcyto_cyto2nuc | nucleusmembrane | MassAction | |
| Dnuc+CK2Dnuc_CK2 | Dnuc_CK2_on | nucleus | MassAction | |
| PP1cyto_D34cytoPP1nuc_D34nuc | PP1cyto_D34cyto_cyto2nuc | nucleusmembrane | MassAction | |
| D3497nuc_PP2BnucD3497cyto_PP2Bcyto | D3497nuc_PP2Bnuc_nuc2cyto | nucleusmembrane | MassAction | |
| D3497nuc_PP2ApnucD34nuc+PP2Apnuc | D3497nuc_PP2Apnuc_cat | nucleus | MassAction | |
| D34nuc_PP2BnucPP2Bnuc+Dnuc | D34nuc_PP2Bnuc_cat | nucleus | MassAction | |
| DcytoDnuc | Dcyto2nuc | nucleusmembrane | MassAction | |
| cAMPsourcecAMP+cAMPsource | cAMPsource2cAMP | cytosol | MassAction | |
| D97nuc_PKAnucD97cyto_PKAcyto | D97nuc_PKAnuc_nuc2cyto | nucleusmembrane | MassAction | |
| cAMP_PDE10AAMP+PDE10A | cAMP_PDE10A_cat | cytosol | MassAction | |
| PP1cyto_D34cytoPP1cyto+D34cyto | PP1cyto_D34cyto_off | cytosol | MassAction | |
| PKAnucPKAcyto | PKAnuc2cyto | nucleusmembrane | MassAction | |
| D3497nuc+PP2ApnucD3497nuc_PP2Apnuc | D3497nuc_PP2Apnuc_on | nucleus | MassAction | |
| PKAnuc+DnucDnuc_PKAnuc | Dnuc_PKAnuc_on | nucleus | MassAction | |
| D34cyto_PP2BcytoD34cyto+PP2Bcyto | D34cyto_PP2Bcyto_off | cytosol | MassAction | |
| D3497cyto_PP2ApcytoPP2Apcyto+D3497cyto | D3497cyto_PP2Apcyto_off | cytosol | MassAction | |
| PP1cytoPP1nuc | PP1cyto2nuc | nucleusmembrane | MassAction | |
| D34nuc_CK2CK2+D34nuc | D34nuc_CK2_off | nucleus | MassAction | |
| PP1nuc_D34nuc_PP2BnucPP1nuc_D34nuc+PP2Bnuc | PP1nuc_D34nuc_PP2Bnuc_off | nucleus | MassAction | |
| PP1nuc_D3497nuc_PP2BnucPP1cyto_D3497cyto_PP2Bcyto | PP1nuc_D3497nuc_PP2Bnuc_nuc2cyto | nucleusmembrane | MassAction | |
| D97cyto+PP2ApcytoD97cyto_PP2Apcyto | D97cyto_PP2Apcyto_on | cytosol | MassAction | |
| cAMP4_R2cAMP+cAMP+cAMP+R2+cAMP | cAMP4_R2_releasecAMP | cytosol | MassAction | |
| PP2Anuc_PKAnucPP2Acyto_PKAcyto | PP2Anuc_PKAnuc_nuc2cyto | nucleusmembrane | MassAction | |
| D34nuc_PP2BnucPP2Bnuc+D34nuc | D34nuc_PP2Bnuc_off | nucleus | MassAction | |
| D97cyto_PP2ApcytoDcyto+PP2Apcyto | D97cyto_PP2Apcyto_cat | cytosol | MassAction | |
| PP1cyto_D3497cyto_PP2BcytoPP1cyto+D97cyto+PP2Bcyto | PP1cyto_D3497cyto_PP2Bcyto_cat | cytosol | MassAction | |
| cAMP+R2C2cAMP_R2C2 | cAMP_R2C2_onoff | cytosol | MassAction | |
| D3497nuc_PP2BnucPP2Bnuc+D97nuc | D3497nuc_PP2Bnuc_cat | nucleus | MassAction | |
| D34nuc+CK2D34nuc_CK2 | D34nuc_CK2_on | nucleus | MassAction | |
| D97nuc_PP2ApnucPP2Apnuc+D97nuc | D97nuc_PP2Apnuc_off | nucleus | MassAction | |
| D34cyto_PP2BcytoD34nuc_PP2Bnuc | D34cyto_PP2Bcyto_cyto2nuc | nucleusmembrane | MassAction | |
| cAMP4_R2C2cAMP4_R2C+PKAcyto | cAMP4_R2C_PKA_onoff | cytosol | MassAction | |
| cAMP+cAMP2_R2C2cAMP3_R2C2 | cAMP_cAMP2_R2C2_onoff | cytosol | MassAction | |
| cAMP4_R2CcAMP4_R2+PKAcyto | cAMP4_R2_PKA_onoff | cytosol | MassAction | |
| D97nucD97cyto | D97nuc2cyto_passive | nucleusmembrane | MassAction | |
| Dcyto_PKAcytoDnuc_PKAnuc | Dcyto_PKAcyto_cyto2nuc | nucleusmembrane | MassAction | |
| PP2ApnucPP2Apcyto | PP2Apnuc2cyto | nucleusmembrane | MassAction | |
| PP2Anuc_PKAnucPP2Anuc+PKAnuc | PP2Anuc_PKANuc_off | nucleus | MassAction | |
| PKAcytoPKAnuc | PKAcyto2nuc | nucleusmembrane | MassAction | |
| PP2Acyto_PKAcytoPP2Anuc_PKAnuc | PP2Acyto_PKAcyto_cyto2nuc | nucleusmembrane | MassAction | |
| D3497cyto+PP1cytoPP1cyto_D3497cyto | PP1cyto_D3497cyto_on | cytosol | MassAction | |
| D97nuc_PP2ApnucD97cyto_PP2Apcyto | D97nuc_PP2Apnuc_nuc2cyto | nucleusmembrane | MassAction | |
| PP2ApcytoPP2Acyto | PP2Apcytodephosphorylation | cytosol | MassAction | |
| PP2BcytoPP2Bnuc | PP2Bcyto2nuc | nucleusmembrane | MassAction | |
| PP1cyto_D3497cyto+PP2BcytoPP1cyto_D3497cyto_PP2Bcyto | PP1cyto_D3497cyto_PP2Bcyto_on | cytosol | MassAction | |
| PP1nuc_D34nuc+PP2BnucPP1nuc_D34nuc_PP2Bnuc | PP1nuc_D34nuc_PP2Bnuc_on | nucleus | MassAction | |
| PP2Apnuc+D97nucD97nuc_PP2Apnuc | D97nuc_PP2Apnuc_on | nucleus | MassAction | |
| D34cytoD34nuc | D34cyto2nuc | nucleusmembrane | MassAction | |
| PP2AcytoPP2Anuc | PP2Acyto2nuc | nucleusmembrane | MassAction | |
| PP1cyto_D3497cyto_PP2BcytoPP1cyto_D3497cyto+PP2Bcyto | PP1cyto_D3497cyto_PP2Bcyto_off | cytosol | MassAction | |
| PP1nucPP1cyto | PP1nuc2cyto | nucleusmembrane | MassAction | |
| D97cytoD97nuc | D97cyto2nuc_passive | nucleusmembrane | MassAction | |
| cAMP+cAMP_R2C2cAMP2_R2C2 | cAMP_cAMP_R2C2_onoff | cytosol | MassAction | |
| PP1cyto_D3497cytoPP1nuc_D3497nuc | PP1cyto_D3497cyto_cyto2nuc | nucleusmembrane | MassAction | |
| PP1nuc_D3497nucPP1cyto_D3497cyto | PP1nuc_D3497nuc_nuc2cyto | nucleusmembrane | MassAction | |
| D34cyto_PP2BcytoDcyto+PP2Bcyto | D34cyto_PP2Bcyto_cat | cytosol | MassAction | |
| D34cyto+PP2BcytoD34cyto_PP2Bcyto | D34cyto_PP2Bcyto_on | cytosol | MassAction | |
| D3497nuc_PP2BnucD3497nuc+PP2Bnuc | D3497nuc_PP2Bnuc_off | nucleus | MassAction | |
| D3497cytoD3497nuc | D3497cyto2nuc_passive | nucleusmembrane | MassAction | |
| D34nucD34cyto | D34nuc2cyto_passive | nucleusmembrane | MassAction | |
| D97cyto_PKAcytoD97nuc_PKAnuc | D97cyto_PKAcyto_cyto2nuc | nucleusmembrane | MassAction | |
| D3497nuc_PP2ApnucPP2Apnuc+D3497nuc | D3497nuc_PP2Apnuc_off | nucleus | MassAction | |
| PP2ApnucPP2Anuc | PP2Apnucdephosphorylation | nucleus | MassAction | |
| D3497nuc+PP1nucPP1nuc_D3497nuc | PP1nuc_D3497nuc_on | nucleus | MassAction | |
| D97cyto+PKAcytoD97cyto_PKAcyto | D97cyto_PKAcyto_on | cytosol | MassAction | |
| PP1cyto+D34cytoPP1cyto_D34cyto | PP1cyto_D34cyto_on | cytosol | MassAction | |
| D97cytoD97nuc | D97cyto2nuc | nucleusmembrane | MassAction | |
| Dnuc_PKAnucPKAnuc+Dnuc | Dnuc_PKAnuc_off | nucleus | MassAction | |
| cAMP3_R2C2+cAMPcAMP4_R2C2 | cAMP_cAMP3_R2C2_onoff | cytosol | MassAction | |
| D3497cyto_PP2ApcytoD3497nuc_PP2Apnuc | D3497cyto_PP2Apcyto_cyto2nuc | nucleusmembrane | MassAction | |
| D3497nuc_PP2ApnucD3497cyto_PP2Apcyto | D3497nuc_PP2Apnuc_nuc2cyto | nucleusmembrane | MassAction | |
| D97cyto_PKAcytoD3497cyto+PKAcyto | D97cyto_PKAcyto_cat | cytosol | MassAction | |
| D97nuc_PKAnucD97nuc+PKAnuc | D97nuc_PKAnuc_off | nucleus | MassAction | |
| cAMP+PDE10AcAMP_PDE10A | cAMP_PDE10A_onoff | cytosol | MassAction |
PP1nuc_D34nuc_off Universal ID's
PP1nuc_D34nuc_off Text Annotations
D3497cyto_PP2Bcyto_off Universal ID's
D3497cyto_PP2Bcyto_off Text Annotations
PP1nuc_D3497nuc_off Universal ID's
PP1nuc_D3497nuc_off Text Annotations
PP1cyto_D34cyto_PP2Bcyto_cyto2nuc Universal ID's
PP1cyto_D34cyto_PP2Bcyto_cyto2nuc Text Annotations
PP2Apcyto2nuc Universal ID's
PP2Apcyto2nuc Text Annotations
D97cyto_PKAcyto_off Universal ID's
D97cyto_PKAcyto_off Text Annotations
PP1cyto_D3497cyto_PP2Bcyto_cyto2nuc Universal ID's
PP1cyto_D3497cyto_PP2Bcyto_cyto2nuc Text Annotations
D97cyto_PP2Apcyto_off Universal ID's
D97cyto_PP2Apcyto_off Text Annotations
D97nuc2cyto Universal ID's
D97nuc2cyto Text Annotations
D3497cyto_PP2Apcyto_on Universal ID's
D3497cyto_PP2Apcyto_on Text Annotations
Dcyto2nuc_passive Universal ID's
Dcyto2nuc_passive Text Annotations
D34cyto2nuc_passive Universal ID's
D34cyto2nuc_passive Text Annotations
D3497cyto_PP2Bcyto_on Universal ID's
D3497cyto_PP2Bcyto_on Text Annotations
PP1nuc_D34nuc_nuc2cyto Universal ID's
PP1nuc_D34nuc_nuc2cyto Text Annotations
Dnuc_CK2_cat Universal ID's
Dnuc_CK2_cat Text Annotations
D3497nuc2cyto Universal ID's
D3497nuc2cyto Text Annotations
D97nuc_PKAnuc_cat Universal ID's
D97nuc_PKAnuc_cat Text Annotations
PP2Anuc_PKAnuc_cat Universal ID's
PP2Anuc_PKAnuc_cat Text Annotations
D97nuc_PP2Apnuc_cat Universal ID's
D97nuc_PP2Apnuc_cat Text Annotations
PP1nuc_D3497nuc_PP2Bnuc_cat Universal ID's
PP1nuc_D3497nuc_PP2Bnuc_cat Text Annotations
PP1nuc_D3497nuc_PP2Bnuc_off Universal ID's
PP1nuc_D3497nuc_PP2Bnuc_off Text Annotations
PP1cyto_D34cyto_PP2Bcyto_cat Universal ID's
PP1cyto_D34cyto_PP2Bcyto_cat Text Annotations
D3497cyto2nuc Universal ID's
D3497cyto2nuc Text Annotations
D3497nuc2cyto_passive Universal ID's
D3497nuc2cyto_passive Text Annotations
D3497nuc_PP2Bnuc_on Universal ID's
D3497nuc_PP2Bnuc_on Text Annotations
PP2Anuc2cyto Universal ID's
PP2Anuc2cyto Text Annotations
PP2Acyto_PKAcyto_cat Universal ID's
PP2Acyto_PKAcyto_cat Text Annotations
PP2Acyto_PKAcyto_off Universal ID's
PP2Acyto_PKAcyto_off Text Annotations
D34nuc_CK2_cat Universal ID's
D34nuc_CK2_cat Text Annotations
Dnuc2cyto_passive Universal ID's
Dnuc2cyto_passive Text Annotations
Dnuc_CK2_off Universal ID's
Dnuc_CK2_off Text Annotations
photoUncaging_DMNB_cAMP Universal ID's
photoUncaging_DMNB_cAMP Text Annotations
Dcyto_PKAcyto_on Universal ID's
Dcyto_PKAcyto_on Text Annotations
Dnuc_PKAnuc_cat Universal ID's
Dnuc_PKAnuc_cat Text Annotations
D97nuc_PKAnuc_on Universal ID's
D97nuc_PKAnuc_on Text Annotations
D3497cyto_PP2Bcyto_cyto2nuc Universal ID's
D3497cyto_PP2Bcyto_cyto2nuc Text Annotations
PP1cyto_D34cyto_PP2Bcyto_on Universal ID's
PP1cyto_D34cyto_PP2Bcyto_on Text Annotations
D34nuc_PP2Bnuc_on Universal ID's
D34nuc_PP2Bnuc_on Text Annotations
R2_PKAcyto_bind Universal ID's
R2_PKAcyto_bind Text Annotations
Dcyto_PKAcyto_off Universal ID's
Dcyto_PKAcyto_off Text Annotations
D3497cyto_PP2Apcyto_cat Universal ID's
D3497cyto_PP2Apcyto_cat Text Annotations
PP2Anuc_PKAnuc_on Universal ID's
PP2Anuc_PKAnuc_on Text Annotations
PP2Bnuc2cyto Universal ID's
PP2Bnuc2cyto Text Annotations
PP2Acyto_PKAcyto_on Universal ID's
PP2Acyto_PKAcyto_on Text Annotations
PP1nuc_D3497nuc_PP2Bnuc_on Universal ID's
PP1nuc_D3497nuc_PP2Bnuc_on Text Annotations
R2C_PKAcyto_bind Universal ID's
R2C_PKAcyto_bind Text Annotations
PP1cyto_D3497_off Universal ID's
PP1cyto_D3497_off Text Annotations
D3497cyto_PP2Bcyto_cat Universal ID's
D3497cyto_PP2Bcyto_cat Text Annotations
PP1nuc_D34nuc_PP2Bnuc_cat Universal ID's
PP1nuc_D34nuc_PP2Bnuc_cat Text Annotations
PP1nuc_D34nuc_on Universal ID's
PP1nuc_D34nuc_on Text Annotations
Dcyto_PKAcyto_cat Universal ID's
Dcyto_PKAcyto_cat Text Annotations
PP1cyto_D34cyto_PP2Bcyto_off Universal ID's
PP1cyto_D34cyto_PP2Bcyto_off Text Annotations
D97cyto_PP2Apcyto_cyto2nuc Universal ID's
D97cyto_PP2Apcyto_cyto2nuc Text Annotations
Dnuc_CK2_on Universal ID's
Dnuc_CK2_on Text Annotations
PP1cyto_D34cyto_cyto2nuc Universal ID's
PP1cyto_D34cyto_cyto2nuc Text Annotations
D3497nuc_PP2Bnuc_nuc2cyto Universal ID's
D3497nuc_PP2Bnuc_nuc2cyto Text Annotations
D3497nuc_PP2Apnuc_cat Universal ID's
D3497nuc_PP2Apnuc_cat Text Annotations
D34nuc_PP2Bnuc_cat Universal ID's
D34nuc_PP2Bnuc_cat Text Annotations
Dcyto2nuc Universal ID's
Dcyto2nuc Text Annotations
cAMPsource2cAMP Universal ID's
cAMPsource2cAMP Text Annotations
D97nuc_PKAnuc_nuc2cyto Universal ID's
D97nuc_PKAnuc_nuc2cyto Text Annotations
cAMP_PDE10A_cat Universal ID's
cAMP_PDE10A_cat Text Annotations
PP1cyto_D34cyto_off Universal ID's
PP1cyto_D34cyto_off Text Annotations
PKAnuc2cyto Universal ID's
PKAnuc2cyto Text Annotations
D3497nuc_PP2Apnuc_on Universal ID's
D3497nuc_PP2Apnuc_on Text Annotations
Dnuc_PKAnuc_on Universal ID's
Dnuc_PKAnuc_on Text Annotations
D34cyto_PP2Bcyto_off Universal ID's
D34cyto_PP2Bcyto_off Text Annotations
D3497cyto_PP2Apcyto_off Universal ID's
D3497cyto_PP2Apcyto_off Text Annotations
PP1cyto2nuc Universal ID's
PP1cyto2nuc Text Annotations
D34nuc_CK2_off Universal ID's
D34nuc_CK2_off Text Annotations
PP1nuc_D34nuc_PP2Bnuc_off Universal ID's
PP1nuc_D34nuc_PP2Bnuc_off Text Annotations
PP1nuc_D3497nuc_PP2Bnuc_nuc2cyto Universal ID's
PP1nuc_D3497nuc_PP2Bnuc_nuc2cyto Text Annotations
D97cyto_PP2Apcyto_on Universal ID's
D97cyto_PP2Apcyto_on Text Annotations
cAMP4_R2_releasecAMP Universal ID's
cAMP4_R2_releasecAMP Text Annotations
PP2Anuc_PKAnuc_nuc2cyto Universal ID's
PP2Anuc_PKAnuc_nuc2cyto Text Annotations
D34nuc_PP2Bnuc_off Universal ID's
D34nuc_PP2Bnuc_off Text Annotations
D97cyto_PP2Apcyto_cat Universal ID's
D97cyto_PP2Apcyto_cat Text Annotations
PP1cyto_D3497cyto_PP2Bcyto_cat Universal ID's
PP1cyto_D3497cyto_PP2Bcyto_cat Text Annotations
cAMP_R2C2_onoff Universal ID's
cAMP_R2C2_onoff Text Annotations
D3497nuc_PP2Bnuc_cat Universal ID's
D3497nuc_PP2Bnuc_cat Text Annotations
D34nuc_CK2_on Universal ID's
D34nuc_CK2_on Text Annotations
D97nuc_PP2Apnuc_off Universal ID's
D97nuc_PP2Apnuc_off Text Annotations
D34cyto_PP2Bcyto_cyto2nuc Universal ID's
D34cyto_PP2Bcyto_cyto2nuc Text Annotations
cAMP4_R2C_PKA_onoff Universal ID's
cAMP4_R2C_PKA_onoff Text Annotations
cAMP_cAMP2_R2C2_onoff Universal ID's
cAMP_cAMP2_R2C2_onoff Text Annotations
cAMP4_R2_PKA_onoff Universal ID's
cAMP4_R2_PKA_onoff Text Annotations
D97nuc2cyto_passive Universal ID's
D97nuc2cyto_passive Text Annotations
Dcyto_PKAcyto_cyto2nuc Universal ID's
Dcyto_PKAcyto_cyto2nuc Text Annotations
PP2Apnuc2cyto Universal ID's
PP2Apnuc2cyto Text Annotations
PP2Anuc_PKANuc_off Universal ID's
PP2Anuc_PKANuc_off Text Annotations
PKAcyto2nuc Universal ID's
PKAcyto2nuc Text Annotations
PP2Acyto_PKAcyto_cyto2nuc Universal ID's
PP2Acyto_PKAcyto_cyto2nuc Text Annotations
PP1cyto_D3497cyto_on Universal ID's
PP1cyto_D3497cyto_on Text Annotations
D97nuc_PP2Apnuc_nuc2cyto Universal ID's
D97nuc_PP2Apnuc_nuc2cyto Text Annotations
PP2Apcytodephosphorylation Universal ID's
PP2Apcytodephosphorylation Text Annotations
PP2Bcyto2nuc Universal ID's
PP2Bcyto2nuc Text Annotations
PP1cyto_D3497cyto_PP2Bcyto_on Universal ID's
PP1cyto_D3497cyto_PP2Bcyto_on Text Annotations
PP1nuc_D34nuc_PP2Bnuc_on Universal ID's
PP1nuc_D34nuc_PP2Bnuc_on Text Annotations
D97nuc_PP2Apnuc_on Universal ID's
D97nuc_PP2Apnuc_on Text Annotations
D34cyto2nuc Universal ID's
D34cyto2nuc Text Annotations
PP2Acyto2nuc Universal ID's
PP2Acyto2nuc Text Annotations
PP1cyto_D3497cyto_PP2Bcyto_off Universal ID's
PP1cyto_D3497cyto_PP2Bcyto_off Text Annotations
PP1nuc2cyto Universal ID's
PP1nuc2cyto Text Annotations
D97cyto2nuc_passive Universal ID's
D97cyto2nuc_passive Text Annotations
cAMP_cAMP_R2C2_onoff Universal ID's
cAMP_cAMP_R2C2_onoff Text Annotations
PP1cyto_D3497cyto_cyto2nuc Universal ID's
PP1cyto_D3497cyto_cyto2nuc Text Annotations
PP1nuc_D3497nuc_nuc2cyto Universal ID's
PP1nuc_D3497nuc_nuc2cyto Text Annotations
D34cyto_PP2Bcyto_cat Universal ID's
D34cyto_PP2Bcyto_cat Text Annotations
D34cyto_PP2Bcyto_on Universal ID's
D34cyto_PP2Bcyto_on Text Annotations
D3497nuc_PP2Bnuc_off Universal ID's
D3497nuc_PP2Bnuc_off Text Annotations
D3497cyto2nuc_passive Universal ID's
D3497cyto2nuc_passive Text Annotations
D34nuc2cyto_passive Universal ID's
D34nuc2cyto_passive Text Annotations
D97cyto_PKAcyto_cyto2nuc Universal ID's
D97cyto_PKAcyto_cyto2nuc Text Annotations
D3497nuc_PP2Apnuc_off Universal ID's
D3497nuc_PP2Apnuc_off Text Annotations
PP2Apnucdephosphorylation Universal ID's
PP2Apnucdephosphorylation Text Annotations
PP1nuc_D3497nuc_on Universal ID's
PP1nuc_D3497nuc_on Text Annotations
D97cyto_PKAcyto_on Universal ID's
D97cyto_PKAcyto_on Text Annotations
PP1cyto_D34cyto_on Universal ID's
PP1cyto_D34cyto_on Text Annotations
D97cyto2nuc Universal ID's
D97cyto2nuc Text Annotations
Dnuc_PKAnuc_off Universal ID's
Dnuc_PKAnuc_off Text Annotations
cAMP_cAMP3_R2C2_onoff Universal ID's
cAMP_cAMP3_R2C2_onoff Text Annotations
D3497cyto_PP2Apcyto_cyto2nuc Universal ID's
D3497cyto_PP2Apcyto_cyto2nuc Text Annotations
D3497nuc_PP2Apnuc_nuc2cyto Universal ID's
D3497nuc_PP2Apnuc_nuc2cyto Text Annotations
D97cyto_PKAcyto_cat Universal ID's
D97cyto_PKAcyto_cat Text Annotations
D97nuc_PKAnuc_off Universal ID's
D97nuc_PKAnuc_off Text Annotations
cAMP_PDE10A_onoff Universal ID's
cAMP_PDE10A_onoff Text Annotations
Expressions for PP1nuc_D34nuc_off
reaction rate
J
((Kf * PP1nuc_D34nuc) - ((Kr * PP1nuc) * D34nuc)) [uM.s-1]
forward rate constant
Kf
PP1_D34_koff [s-1]
global
PP1_D34_koff
0.4 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-1]
Expressions for D3497cyto_PP2Bcyto_off
reaction rate
J
((Kf * D3497cyto_PP2Bcyto) - ((Kr * D3497cyto) * PP2Bcyto)) [uM.s-1]
forward rate constant
Kf
D34_PP2B_koff [s-1]
global
D34_PP2B_koff
6.4 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-1]
Expressions for PP1nuc_D3497nuc_off
reaction rate
J
((Kf * PP1nuc_D3497nuc) - ((Kr * PP1nuc) * D3497nuc)) [uM.s-1]
forward rate constant
Kf
PP1_D34_koff [s-1]
global
PP1_D34_koff
0.4 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-1]
Expressions for PP1cyto_D34cyto_PP2Bcyto_cyto2nuc
reaction rate
J
((Kf * PP1cyto_D34cyto_PP2Bcyto) - (Kr * PP1nuc_D34nuc_PP2Bnuc)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
1.0 [1]
forward rate constant
Kf
kDcyto2nuc [molecules.um-2.s-1.uM-1]
global
kDcyto2nuc
80.0 [molecules.um-2.uM-1.s-1]
reverse rate constant
Kr
0.0 [molecules.um-2.s-1.uM-1]
Expressions for PP2Apcyto2nuc
reaction rate
J
((Kf * PP2Apcyto) - (Kr * PP2Apnuc)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
1.0 [1]
forward rate constant
Kf
0.0 [molecules.um-2.s-1.uM-1]
reverse rate constant
Kr
0.0 [molecules.um-2.s-1.uM-1]
Expressions for D97cyto_PKAcyto_off
reaction rate
J
((Kf * D97cyto_PKAcyto) - ((Kr * PKAcyto) * D97cyto)) [uM.s-1]
forward rate constant
Kf
D_PKA_koff [s-1]
global
D_PKA_koff
10.8 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-1]
Expressions for PP1cyto_D3497cyto_PP2Bcyto_cyto2nuc
reaction rate
J
((Kf * PP1cyto_D3497cyto_PP2Bcyto) - (Kr * PP1nuc_D3497nuc_PP2Bnuc)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
1.0 [1]
forward rate constant
Kf
kDcyto2nuc [molecules.um-2.s-1.uM-1]
global
kDcyto2nuc
80.0 [molecules.um-2.uM-1.s-1]
reverse rate constant
Kr
0.0 [molecules.um-2.s-1.uM-1]
Expressions for D97cyto_PP2Apcyto_off
reaction rate
J
((Kf * D97cyto_PP2Apcyto) - ((Kr * PP2Apcyto) * D97cyto)) [uM.s-1]
forward rate constant
Kf
D97_PP2Ap_koff [s-1]
global
D97_PP2Ap_koff
4.45 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-1]
Expressions for D97nuc2cyto
reaction rate
J
((Kf * D97nuc) - (Kr * D97cyto)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
1.0 [1]
forward rate constant
Kf
kD97nuc2cyto [molecules.um-2.s-1.uM-1]
global
kD97nuc2cyto
133.6313 [molecules.um-2.uM-1.s-1]
reverse rate constant
Kr
0.0 [molecules.um-2.s-1.uM-1]
Expressions for D3497cyto_PP2Apcyto_on
reaction rate
J
(((Kf * D3497cyto) * PP2Apcyto) - (Kr * D3497cyto_PP2Apcyto)) [uM.s-1]
forward rate constant
Kf
D97_PP2Ap_kon [s-1.uM-1]
global
D97_PP2Ap_kon
2.7 [uM-1.s-1]
reverse rate constant
Kr
0.0 [s-1]
Expressions for Dcyto2nuc_passive
reaction rate
J
((Kf * Dcyto) - (Kr * Dnuc)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
1.0 [1]
forward rate constant
Kf
kDcyto2nuc_passive [molecules.um-2.s-1.uM-1]
global
kDcyto2nuc
80.0 [molecules.um-2.uM-1.s-1]
global
kDcyto2nuc_passive
1.62 [molecules.um-2.uM-1.s-1]
reverse rate constant
Kr
0.0 [molecules.um-2.s-1.uM-1]
Expressions for D34cyto2nuc_passive
reaction rate
J
((Kf * D34cyto) - (Kr * D34nuc)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
1.0 [1]
forward rate constant
Kf
kDcyto2nuc_passive [molecules.um-2.s-1.uM-1]
global
kDcyto2nuc
80.0 [molecules.um-2.uM-1.s-1]
global
kDcyto2nuc_passive
1.62 [molecules.um-2.uM-1.s-1]
reverse rate constant
Kr
0.0 [molecules.um-2.s-1.uM-1]
Expressions for D3497cyto_PP2Bcyto_on
reaction rate
J
(((Kf * PP2Bcyto) * D3497cyto) - (Kr * D3497cyto_PP2Bcyto)) [uM.s-1]
forward rate constant
Kf
D34_PP2B_kon [s-1.uM-1]
global
D34_PP2B_kon
4.1 [uM-1.s-1]
reverse rate constant
Kr
0.0 [s-1]
Expressions for PP1nuc_D34nuc_nuc2cyto
reaction rate
J
((Kf * PP1nuc_D34nuc) - (Kr * PP1cyto_D34cyto)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
1.0 [1]
forward rate constant
Kf
0.0 [molecules.um-2.s-1.uM-1]
reverse rate constant
Kr
0.0 [molecules.um-2.s-1.uM-1]
Expressions for Dnuc_CK2_cat
reaction rate
J
((Kf * Dnuc_CK2) - ((Kr * D97nuc) * CK2)) [uM.s-1]
forward rate constant
Kf
D_CK2_kcat [s-1]
global
D_CK2_kcat
0.32 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-1]
Expressions for D3497nuc2cyto
reaction rate
J
((Kf * D3497nuc) - (Kr * D3497cyto)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
1.0 [1]
forward rate constant
Kf
kD97nuc2cyto [molecules.um-2.s-1.uM-1]
global
kD97nuc2cyto
133.6313 [molecules.um-2.uM-1.s-1]
reverse rate constant
Kr
0.0 [molecules.um-2.s-1.uM-1]
Expressions for D97nuc_PKAnuc_cat
reaction rate
J
((Kf * D97nuc_PKAnuc) - ((Kr * D3497nuc) * PKAnuc)) [uM.s-1]
forward rate constant
Kf
D_PKA_kcat [s-1]
global
D_PKA_kcat
2.7 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-1]
Expressions for PP2Anuc_PKAnuc_cat
reaction rate
J
((Kf * PP2Anuc_PKAnuc) - ((Kr * PP2Apnuc) * PKAnuc)) [uM.s-1]
forward rate constant
Kf
PP2A_PKA_kcat [s-1]
global
PP2A_PKA_kcat
0.3 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-1]
Expressions for D97nuc_PP2Apnuc_cat
reaction rate
J
((Kf * D97nuc_PP2Apnuc) - ((Kr * PP2Apnuc) * Dnuc)) [uM.s-1]
forward rate constant
Kf
D97_PP2Ap_kcat [s-1]
global
D97_PP2Ap_kcat
0.2 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-1]
Expressions for PP1nuc_D3497nuc_PP2Bnuc_cat
reaction rate
J
((Kf * PP1nuc_D3497nuc_PP2Bnuc) - (((Kr * PP2Bnuc) * PP1nuc) * D97nuc)) [uM.s-1]
forward rate constant
Kf
D34_PP2B_kcat [s-1]
global
D34_PP2B_kcat
0.1 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-2]
Expressions for PP1nuc_D3497nuc_PP2Bnuc_off
reaction rate
J
((Kf * PP1nuc_D3497nuc_PP2Bnuc) - ((Kr * PP1nuc_D3497nuc) * PP2Bnuc)) [uM.s-1]
forward rate constant
Kf
D34_PP2B_koff [s-1]
global
D34_PP2B_koff
6.4 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-1]
Expressions for PP1cyto_D34cyto_PP2Bcyto_cat
reaction rate
J
((Kf * PP1cyto_D34cyto_PP2Bcyto) - (((Kr * Dcyto) * PP2Bcyto) * PP1cyto)) [uM.s-1]
forward rate constant
Kf
D34_PP2B_kcat [s-1]
global
D34_PP2B_kcat
0.1 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-2]
Expressions for D3497cyto2nuc
reaction rate
J
((Kf * D3497cyto) - (Kr * D3497nuc)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
1.0 [1]
forward rate constant
Kf
kDcyto2nuc [molecules.um-2.s-1.uM-1]
global
kDcyto2nuc
80.0 [molecules.um-2.uM-1.s-1]
reverse rate constant
Kr
0.0 [molecules.um-2.s-1.uM-1]
Expressions for D3497nuc2cyto_passive
reaction rate
J
((Kf * D3497nuc) - (Kr * D3497cyto)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
1.0 [1]
forward rate constant
Kf
kDnuc2cyto_passive [molecules.um-2.s-1.uM-1]
global
kDnuc2cyto_passive
1.62 [molecules.um-2.uM-1.s-1]
reverse rate constant
Kr
0.0 [molecules.um-2.s-1.uM-1]
Expressions for D3497nuc_PP2Bnuc_on
reaction rate
J
(((Kf * D3497nuc) * PP2Bnuc) - (Kr * D3497nuc_PP2Bnuc)) [uM.s-1]
forward rate constant
Kf
D34_PP2B_kon [s-1.uM-1]
global
D34_PP2B_kon
4.1 [uM-1.s-1]
reverse rate constant
Kr
0.0 [s-1]
Expressions for PP2Anuc2cyto
reaction rate
J
((Kf * PP2Anuc) - (Kr * PP2Acyto)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
1.0 [1]
forward rate constant
Kf
0.0 [molecules.um-2.s-1.uM-1]
reverse rate constant
Kr
0.0 [molecules.um-2.s-1.uM-1]
Expressions for PP2Acyto_PKAcyto_cat
reaction rate
J
((Kf * PP2Acyto_PKAcyto) - ((Kr * PKAcyto) * PP2Apcyto)) [uM.s-1]
forward rate constant
Kf
PP2A_PKA_kcat [s-1]
global
PP2A_PKA_kcat
0.3 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-1]
Expressions for PP2Acyto_PKAcyto_off
reaction rate
J
((Kf * PP2Acyto_PKAcyto) - ((Kr * PKAcyto) * PP2Acyto)) [uM.s-1]
forward rate constant
Kf
PP2A_PKA_koff [s-1]
global
PP2A_PKA_koff
0.1 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-1]
Expressions for D34nuc_CK2_cat
reaction rate
J
((Kf * D34nuc_CK2) - ((Kr * CK2) * D3497nuc)) [uM.s-1]
forward rate constant
Kf
D_CK2_kcat [s-1]
global
D_CK2_kcat
0.32 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-1]
Expressions for Dnuc2cyto_passive
reaction rate
J
((Kf * Dnuc) - (Kr * Dcyto)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
1.0 [1]
forward rate constant
Kf
kDnuc2cyto_passive [molecules.um-2.s-1.uM-1]
global
kDnuc2cyto_passive
1.62 [molecules.um-2.uM-1.s-1]
reverse rate constant
Kr
0.0 [molecules.um-2.s-1.uM-1]
Expressions for Dnuc_CK2_off
reaction rate
J
((Kf * Dnuc_CK2) - ((Kr * Dnuc) * CK2)) [uM.s-1]
forward rate constant
Kf
D_CK2_koff [s-1]
global
D_CK2_koff
10.0 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-1]
Expressions for photoUncaging_DMNB_cAMP
reaction rate
J
(kphoto * light * DMNB_cAMP) [uM.s-1]
local
light
(((t > ton_global) * (t < toff_global)) + ((t > ton_local) * (t < toff_local) * light_spot)) [tbd]
local
kphoto
0.1 [tbd]
local
ton_global
0.0 [tbd]
local
toff_global
0.0 [tbd]
local
ton_local
0.0 [tbd]
local
toff_local
0.0 [tbd]
Expressions for Dcyto_PKAcyto_on
reaction rate
J
(((Kf * Dcyto) * PKAcyto) - (Kr * Dcyto_PKAcyto)) [uM.s-1]
forward rate constant
Kf
D_PKA_kon [s-1.uM-1]
global
D_PKA_kon
5.6 [uM-1.s-1]
reverse rate constant
Kr
0.0 [s-1]
Expressions for Dnuc_PKAnuc_cat
reaction rate
J
((Kf * Dnuc_PKAnuc) - ((Kr * D34nuc) * PKAnuc)) [uM.s-1]
forward rate constant
Kf
D_PKA_kcat [s-1]
global
D_PKA_kcat
2.7 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-1]
Expressions for D97nuc_PKAnuc_on
reaction rate
J
(((Kf * D97nuc) * PKAnuc) - (Kr * D97nuc_PKAnuc)) [uM.s-1]
forward rate constant
Kf
D_PKA_kon [s-1.uM-1]
global
D_PKA_kon
5.6 [uM-1.s-1]
reverse rate constant
Kr
0.0 [s-1]
Expressions for D3497cyto_PP2Bcyto_cyto2nuc
reaction rate
J
((Kf * D3497cyto_PP2Bcyto) - (Kr * D3497nuc_PP2Bnuc)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
1.0 [1]
forward rate constant
Kf
kDcyto2nuc [molecules.um-2.s-1.uM-1]
global
kDcyto2nuc
80.0 [molecules.um-2.uM-1.s-1]
reverse rate constant
Kr
0.0 [molecules.um-2.s-1.uM-1]
Expressions for PP1cyto_D34cyto_PP2Bcyto_on
reaction rate
J
(((Kf * PP2Bcyto) * PP1cyto_D34cyto) - (Kr * PP1cyto_D34cyto_PP2Bcyto)) [uM.s-1]
forward rate constant
Kf
D34_PP2B_kon [s-1.uM-1]
global
D34_PP2B_kon
4.1 [uM-1.s-1]
reverse rate constant
Kr
0.0 [s-1]
Expressions for D34nuc_PP2Bnuc_on
reaction rate
J
(((Kf * D34nuc) * PP2Bnuc) - (Kr * D34nuc_PP2Bnuc)) [uM.s-1]
forward rate constant
Kf
D34_PP2B_kon [s-1.uM-1]
global
D34_PP2B_kon
4.1 [uM-1.s-1]
reverse rate constant
Kr
0.0 [s-1]
Expressions for R2_PKAcyto_bind
reaction rate
J
(((Kf * R2) * PKAcyto) - (Kr * R2C)) [uM.s-1]
forward rate constant
Kf
18.0 [s-1.uM-1]
reverse rate constant
Kr
0.0 [s-1]
Expressions for Dcyto_PKAcyto_off
reaction rate
J
((Kf * Dcyto_PKAcyto) - ((Kr * PKAcyto) * Dcyto)) [uM.s-1]
forward rate constant
Kf
D_PKA_koff [s-1]
global
D_PKA_koff
10.8 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-1]
Expressions for D3497cyto_PP2Apcyto_cat
reaction rate
J
((Kf * D3497cyto_PP2Apcyto) - ((Kr * D34cyto) * PP2Apcyto)) [uM.s-1]
forward rate constant
Kf
D97_PP2Ap_kcat [s-1]
global
D97_PP2Ap_kcat
0.2 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-1]
Expressions for PP2Anuc_PKAnuc_on
reaction rate
J
(((Kf * PP2Anuc) * PKAnuc) - (Kr * PP2Anuc_PKAnuc)) [uM.s-1]
forward rate constant
Kf
PP2A_PKA_kon [s-1.uM-1]
global
PP2A_PKA_kon
2.4 [uM-1.s-1]
reverse rate constant
Kr
0.0 [s-1]
Expressions for PP2Bnuc2cyto
reaction rate
J
((Kf * PP2Bnuc) - (Kr * PP2Bcyto)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
1.0 [1]
forward rate constant
Kf
0.0 [molecules.um-2.s-1.uM-1]
reverse rate constant
Kr
0.0 [molecules.um-2.s-1.uM-1]
Expressions for PP2Acyto_PKAcyto_on
reaction rate
J
(((Kf * PP2Acyto) * PKAcyto) - (Kr * PP2Acyto_PKAcyto)) [uM.s-1]
forward rate constant
Kf
PP2A_PKA_kon [s-1.uM-1]
global
PP2A_PKA_kon
2.4 [uM-1.s-1]
reverse rate constant
Kr
0.0 [s-1]
Expressions for PP1nuc_D3497nuc_PP2Bnuc_on
reaction rate
J
(((Kf * PP2Bnuc) * PP1nuc_D3497nuc) - (Kr * PP1nuc_D3497nuc_PP2Bnuc)) [uM.s-1]
forward rate constant
Kf
D34_PP2B_kon [s-1.uM-1]
global
D34_PP2B_kon
4.1 [uM-1.s-1]
reverse rate constant
Kr
0.0 [s-1]
Expressions for R2C_PKAcyto_bind
reaction rate
J
(((Kf * R2C) * PKAcyto) - (Kr * R2C2)) [uM.s-1]
forward rate constant
Kf
18.0 [s-1.uM-1]
reverse rate constant
Kr
0.0 [s-1]
Expressions for PP1cyto_D3497_off
reaction rate
J
((Kf * PP1cyto_D3497cyto) - ((Kr * PP1cyto) * D3497cyto)) [uM.s-1]
forward rate constant
Kf
PP1_D34_koff [s-1]
global
PP1_D34_koff
0.4 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-1]
Expressions for D3497cyto_PP2Bcyto_cat
reaction rate
J
((Kf * D3497cyto_PP2Bcyto) - ((Kr * D97cyto) * PP2Bcyto)) [uM.s-1]
forward rate constant
Kf
D34_PP2B_kcat [s-1]
global
D34_PP2B_kcat
0.1 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-1]
Expressions for PP1nuc_D34nuc_PP2Bnuc_cat
reaction rate
J
((Kf * PP1nuc_D34nuc_PP2Bnuc) - (((Kr * PP1nuc) * Dnuc) * PP2Bnuc)) [uM.s-1]
forward rate constant
Kf
D34_PP2B_kcat [s-1]
global
D34_PP2B_kcat
0.1 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-2]
Expressions for PP1nuc_D34nuc_on
reaction rate
J
(((Kf * D34nuc) * PP1nuc) - (Kr * PP1nuc_D34nuc)) [uM.s-1]
forward rate constant
Kf
PP1_D34_kon [s-1.uM-1]
global
PP1_D34_kon
40.0 [uM-1.s-1]
reverse rate constant
Kr
0.0 [s-1]
Expressions for Dcyto_PKAcyto_cat
reaction rate
J
((Kf * Dcyto_PKAcyto) - ((Kr * PKAcyto) * D34cyto)) [uM.s-1]
forward rate constant
Kf
D_PKA_kcat [s-1]
global
D_PKA_kcat
2.7 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-1]
Expressions for PP1cyto_D34cyto_PP2Bcyto_off
reaction rate
J
((Kf * PP1cyto_D34cyto_PP2Bcyto) - ((Kr * PP2Bcyto) * PP1cyto_D34cyto)) [uM.s-1]
forward rate constant
Kf
D34_PP2B_koff [s-1]
global
D34_PP2B_koff
6.4 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-1]
Expressions for D97cyto_PP2Apcyto_cyto2nuc
reaction rate
J
((Kf * D97cyto_PP2Apcyto) - (Kr * D97nuc_PP2Apnuc)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
1.0 [1]
forward rate constant
Kf
kDcyto2nuc [molecules.um-2.s-1.uM-1]
global
kDcyto2nuc
80.0 [molecules.um-2.uM-1.s-1]
reverse rate constant
Kr
0.0 [molecules.um-2.s-1.uM-1]
Expressions for Dnuc_CK2_on
reaction rate
J
(((Kf * Dnuc) * CK2) - (Kr * Dnuc_CK2)) [uM.s-1]
forward rate constant
Kf
D_CK2_kon [s-1.uM-1]
global
D_CK2_kon
3.0 [uM-1.s-1]
reverse rate constant
Kr
0.0 [s-1]
Expressions for PP1cyto_D34cyto_cyto2nuc
reaction rate
J
((Kf * PP1cyto_D34cyto) - (Kr * PP1nuc_D34nuc)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
1.0 [1]
forward rate constant
Kf
kDcyto2nuc [molecules.um-2.s-1.uM-1]
global
kDcyto2nuc
80.0 [molecules.um-2.uM-1.s-1]
reverse rate constant
Kr
0.0 [molecules.um-2.s-1.uM-1]
Expressions for D3497nuc_PP2Bnuc_nuc2cyto
reaction rate
J
((Kf * D3497nuc_PP2Bnuc) - (Kr * D3497cyto_PP2Bcyto)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
1.0 [1]
forward rate constant
Kf
kD97nuc2cyto [molecules.um-2.s-1.uM-1]
global
kD97nuc2cyto
133.6313 [molecules.um-2.uM-1.s-1]
reverse rate constant
Kr
0.0 [molecules.um-2.s-1.uM-1]
Expressions for D3497nuc_PP2Apnuc_cat
reaction rate
J
((Kf * D3497nuc_PP2Apnuc) - ((Kr * D34nuc) * PP2Apnuc)) [uM.s-1]
forward rate constant
Kf
D97_PP2Ap_kcat [s-1]
global
D97_PP2Ap_kcat
0.2 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-1]
Expressions for D34nuc_PP2Bnuc_cat
reaction rate
J
((Kf * D34nuc_PP2Bnuc) - ((Kr * PP2Bnuc) * Dnuc)) [uM.s-1]
forward rate constant
Kf
D34_PP2B_kcat [s-1]
global
D34_PP2B_kcat
0.1 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-1]
Expressions for Dcyto2nuc
reaction rate
J
((Kf * Dcyto) - (Kr * Dnuc)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
1.0 [1]
forward rate constant
Kf
kDcyto2nuc [molecules.um-2.s-1.uM-1]
global
kDcyto2nuc
80.0 [molecules.um-2.uM-1.s-1]
reverse rate constant
Kr
0.0 [molecules.um-2.s-1.uM-1]
Expressions for cAMPsource2cAMP
reaction rate
J
((Kf * cAMPsource) - ((Kr * cAMP) * cAMPsource)) [uM.s-1]
forward rate constant
Kf
0.1 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-1]
Expressions for D97nuc_PKAnuc_nuc2cyto
reaction rate
J
((Kf * D97nuc_PKAnuc) - (Kr * D97cyto_PKAcyto)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
1.0 [1]
forward rate constant
Kf
kD97nuc2cyto [molecules.um-2.s-1.uM-1]
global
kD97nuc2cyto
133.6313 [molecules.um-2.uM-1.s-1]
reverse rate constant
Kr
0.0 [molecules.um-2.s-1.uM-1]
Expressions for cAMP_PDE10A_cat
reaction rate
J
((Kf * cAMP_PDE10A) - ((Kr * AMP) * PDE10A)) [uM.s-1]
forward rate constant
Kf
cAMP_PDE10A_kcat [s-1]
global
cAMP_PDE10A_kcat
0.5 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-1]
Expressions for PP1cyto_D34cyto_off
reaction rate
J
((Kf * PP1cyto_D34cyto) - ((Kr * PP1cyto) * D34cyto)) [uM.s-1]
forward rate constant
Kf
PP1_D34_koff [s-1]
global
PP1_D34_koff
0.4 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-1]
Expressions for PKAnuc2cyto
reaction rate
J
((Kf * PKAnuc) - (Kr * PKAcyto)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
1.0 [1]
forward rate constant
Kf
kPKAnuc2cyto_passive [molecules.um-2.s-1.uM-1]
global
kPKAnuc2cyto_passive
2.73 [molecules.um-2.uM-1.s-1]
reverse rate constant
Kr
0.0 [molecules.um-2.s-1.uM-1]
Expressions for D3497nuc_PP2Apnuc_on
reaction rate
J
(((Kf * D3497nuc) * PP2Apnuc) - (Kr * D3497nuc_PP2Apnuc)) [uM.s-1]
forward rate constant
Kf
D97_PP2Ap_kon [s-1.uM-1]
global
D97_PP2Ap_kon
2.7 [uM-1.s-1]
reverse rate constant
Kr
0.0 [s-1]
Expressions for Dnuc_PKAnuc_on
reaction rate
J
(((Kf * PKAnuc) * Dnuc) - (Kr * Dnuc_PKAnuc)) [uM.s-1]
forward rate constant
Kf
D_PKA_kon [s-1.uM-1]
global
D_PKA_kon
5.6 [uM-1.s-1]
reverse rate constant
Kr
0.0 [s-1]
Expressions for D34cyto_PP2Bcyto_off
reaction rate
J
((Kf * D34cyto_PP2Bcyto) - ((Kr * D34cyto) * PP2Bcyto)) [uM.s-1]
forward rate constant
Kf
D34_PP2B_koff [s-1]
global
D34_PP2B_koff
6.4 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-1]
Expressions for D3497cyto_PP2Apcyto_off
reaction rate
J
((Kf * D3497cyto_PP2Apcyto) - ((Kr * PP2Apcyto) * D3497cyto)) [uM.s-1]
forward rate constant
Kf
D97_PP2Ap_koff [s-1]
global
D97_PP2Ap_koff
4.45 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-1]
Expressions for PP1cyto2nuc
reaction rate
J
((Kf * PP1cyto) - (Kr * PP1nuc)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
1.0 [1]
forward rate constant
Kf
0.0 [molecules.um-2.s-1.uM-1]
reverse rate constant
Kr
0.0 [molecules.um-2.s-1.uM-1]
Expressions for D34nuc_CK2_off
reaction rate
J
((Kf * D34nuc_CK2) - ((Kr * CK2) * D34nuc)) [uM.s-1]
forward rate constant
Kf
D_CK2_koff [s-1]
global
D_CK2_koff
10.0 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-1]
Expressions for PP1nuc_D34nuc_PP2Bnuc_off
reaction rate
J
((Kf * PP1nuc_D34nuc_PP2Bnuc) - ((Kr * PP1nuc_D34nuc) * PP2Bnuc)) [uM.s-1]
forward rate constant
Kf
D34_PP2B_koff [s-1]
global
D34_PP2B_koff
6.4 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-1]
Expressions for PP1nuc_D3497nuc_PP2Bnuc_nuc2cyto
reaction rate
J
((Kf * PP1nuc_D3497nuc_PP2Bnuc) - (Kr * PP1cyto_D3497cyto_PP2Bcyto)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
1.0 [1]
forward rate constant
Kf
kD97nuc2cyto [molecules.um-2.s-1.uM-1]
global
kD97nuc2cyto
133.6313 [molecules.um-2.uM-1.s-1]
reverse rate constant
Kr
0.0 [molecules.um-2.s-1.uM-1]
Expressions for D97cyto_PP2Apcyto_on
reaction rate
J
(((Kf * D97cyto) * PP2Apcyto) - (Kr * D97cyto_PP2Apcyto)) [uM.s-1]
forward rate constant
Kf
D97_PP2Ap_kon [s-1.uM-1]
global
D97_PP2Ap_kon
2.7 [uM-1.s-1]
reverse rate constant
Kr
0.0 [s-1]
Expressions for cAMP4_R2_releasecAMP
reaction rate
J
((Kf * cAMP4_R2) - (((((Kr * cAMP) * cAMP) * cAMP) * R2) * cAMP)) [uM.s-1]
forward rate constant
Kf
0.0012 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-4]
Expressions for PP2Anuc_PKAnuc_nuc2cyto
reaction rate
J
((Kf * PP2Anuc_PKAnuc) - (Kr * PP2Acyto_PKAcyto)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
1.0 [1]
forward rate constant
Kf
0.0 [molecules.um-2.s-1.uM-1]
reverse rate constant
Kr
0.0 [molecules.um-2.s-1.uM-1]
Expressions for D34nuc_PP2Bnuc_off
reaction rate
J
((Kf * D34nuc_PP2Bnuc) - ((Kr * PP2Bnuc) * D34nuc)) [uM.s-1]
forward rate constant
Kf
D34_PP2B_koff [s-1]
global
D34_PP2B_koff
6.4 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-1]
Expressions for D97cyto_PP2Apcyto_cat
reaction rate
J
((Kf * D97cyto_PP2Apcyto) - ((Kr * Dcyto) * PP2Apcyto)) [uM.s-1]
forward rate constant
Kf
D97_PP2Ap_kcat [s-1]
global
D97_PP2Ap_kcat
0.2 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-1]
Expressions for PP1cyto_D3497cyto_PP2Bcyto_cat
reaction rate
J
((Kf * PP1cyto_D3497cyto_PP2Bcyto) - (((Kr * PP1cyto) * D97cyto) * PP2Bcyto)) [uM.s-1]
forward rate constant
Kf
D34_PP2B_kcat [s-1]
global
D34_PP2B_kcat
0.1 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-2]
Expressions for cAMP_R2C2_onoff
reaction rate
J
(((Kf * cAMP) * R2C2) - (Kr * cAMP_R2C2)) [uM.s-1]
forward rate constant
Kf
cAMP_R2C2_kon [s-1.uM-1]
global
cAMP_R2C2_kon
54.0 [uM-1.s-1]
reverse rate constant
Kr
cAMP_R2C2_koff [s-1]
global
cAMP_R2C2_koff
3.0 [s-1]
Expressions for D3497nuc_PP2Bnuc_cat
reaction rate
J
((Kf * D3497nuc_PP2Bnuc) - ((Kr * PP2Bnuc) * D97nuc)) [uM.s-1]
forward rate constant
Kf
D34_PP2B_kcat [s-1]
global
D34_PP2B_kcat
0.1 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-1]
Expressions for D34nuc_CK2_on
reaction rate
J
(((Kf * D34nuc) * CK2) - (Kr * D34nuc_CK2)) [uM.s-1]
forward rate constant
Kf
D_CK2_kon [s-1.uM-1]
global
D_CK2_kon
3.0 [uM-1.s-1]
reverse rate constant
Kr
0.0 [s-1]
Expressions for D97nuc_PP2Apnuc_off
reaction rate
J
((Kf * D97nuc_PP2Apnuc) - ((Kr * PP2Apnuc) * D97nuc)) [uM.s-1]
forward rate constant
Kf
D97_PP2Ap_koff [s-1]
global
D97_PP2Ap_koff
4.45 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-1]
Expressions for D34cyto_PP2Bcyto_cyto2nuc
reaction rate
J
((Kf * D34cyto_PP2Bcyto) - (Kr * D34nuc_PP2Bnuc)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
1.0 [1]
forward rate constant
Kf
kDcyto2nuc [molecules.um-2.s-1.uM-1]
global
kDcyto2nuc
80.0 [molecules.um-2.uM-1.s-1]
reverse rate constant
Kr
0.0 [molecules.um-2.s-1.uM-1]
Expressions for cAMP4_R2C_PKA_onoff
reaction rate
J
((Kf * cAMP4_R2C2) - ((Kr * cAMP4_R2C) * PKAcyto)) [uM.s-1]
forward rate constant
Kf
cAMP4R2C_PKA_koff [s-1]
global
cAMP4R2C_PKA_koff
0.1 [s-1]
reverse rate constant
Kr
cAMP4R2C_PKA_kon [s-1.uM-1]
global
cAMP4R2C_PKA_kon
18.0 [uM-1.s-1]
Expressions for cAMP_cAMP2_R2C2_onoff
reaction rate
J
(((Kf * cAMP) * cAMP2_R2C2) - (Kr * cAMP3_R2C2)) [uM.s-1]
forward rate constant
Kf
cAMP_cAMP2R2C2_kon [s-1.uM-1]
global
cAMP_cAMP2R2C2_kon
75.0 [uM-1.s-1]
reverse rate constant
Kr
cAMP_cAMP2R2C2_koff [s-1]
global
cAMP_cAMP2R2C2_koff
110.0 [s-1]
Expressions for cAMP4_R2_PKA_onoff
reaction rate
J
((Kf * cAMP4_R2C) - ((Kr * cAMP4_R2) * PKAcyto)) [uM.s-1]
forward rate constant
Kf
cAMP4R2_PKA_koff [s-1]
global
cAMP4R2_PKA_koff
0.1 [s-1]
reverse rate constant
Kr
cAMP4R2_PKA_kon [s-1.uM-1]
global
cAMP4R2_PKA_kon
18.0 [uM-1.s-1]
Expressions for D97nuc2cyto_passive
reaction rate
J
((Kf * D97nuc) - (Kr * D97cyto)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
1.0 [1]
forward rate constant
Kf
kDnuc2cyto_passive [molecules.um-2.s-1.uM-1]
global
kDnuc2cyto_passive
1.62 [molecules.um-2.uM-1.s-1]
reverse rate constant
Kr
0.0 [molecules.um-2.s-1.uM-1]
Expressions for Dcyto_PKAcyto_cyto2nuc
reaction rate
J
((Kf * Dcyto_PKAcyto) - (Kr * Dnuc_PKAnuc)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
1.0 [1]
forward rate constant
Kf
kDcyto2nuc [molecules.um-2.s-1.uM-1]
global
kDcyto2nuc
80.0 [molecules.um-2.uM-1.s-1]
reverse rate constant
Kr
0.0 [molecules.um-2.s-1.uM-1]
Expressions for PP2Apnuc2cyto
reaction rate
J
((Kf * PP2Apnuc) - (Kr * PP2Apcyto)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
1.0 [1]
forward rate constant
Kf
0.0 [molecules.um-2.s-1.uM-1]
reverse rate constant
Kr
0.0 [molecules.um-2.s-1.uM-1]
Expressions for PP2Anuc_PKANuc_off
reaction rate
J
((Kf * PP2Anuc_PKAnuc) - ((Kr * PP2Anuc) * PKAnuc)) [uM.s-1]
forward rate constant
Kf
PP2A_PKA_koff [s-1]
global
PP2A_PKA_koff
0.1 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-1]
Expressions for PKAcyto2nuc
reaction rate
J
((Kf * PKAcyto) - (Kr * PKAnuc)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
1.0 [1]
forward rate constant
Kf
kPKAcyto2nuc_passive [molecules.um-2.s-1.uM-1]
global
kPKAcyto2nuc_passive
2.73 [molecules.um-2.uM-1.s-1]
reverse rate constant
Kr
0.0 [molecules.um-2.s-1.uM-1]
Expressions for PP2Acyto_PKAcyto_cyto2nuc
reaction rate
J
((Kf * PP2Acyto_PKAcyto) - (Kr * PP2Anuc_PKAnuc)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
1.0 [1]
forward rate constant
Kf
0.0 [molecules.um-2.s-1.uM-1]
reverse rate constant
Kr
0.0 [molecules.um-2.s-1.uM-1]
Expressions for PP1cyto_D3497cyto_on
reaction rate
J
(((Kf * D3497cyto) * PP1cyto) - (Kr * PP1cyto_D3497cyto)) [uM.s-1]
forward rate constant
Kf
PP1_D34_kon [s-1.uM-1]
global
PP1_D34_kon
40.0 [uM-1.s-1]
reverse rate constant
Kr
0.0 [s-1]
Expressions for D97nuc_PP2Apnuc_nuc2cyto
reaction rate
J
((Kf * D97nuc_PP2Apnuc) - (Kr * D97cyto_PP2Apcyto)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
1.0 [1]
forward rate constant
Kf
kD97nuc2cyto [molecules.um-2.s-1.uM-1]
global
kD97nuc2cyto
133.6313 [molecules.um-2.uM-1.s-1]
reverse rate constant
Kr
0.0 [molecules.um-2.s-1.uM-1]
Expressions for PP2Apcytodephosphorylation
reaction rate
J
((Kf * PP2Apcyto) - (Kr * PP2Acyto)) [uM.s-1]
forward rate constant
Kf
0.1 [s-1]
reverse rate constant
Kr
0.0 [s-1]
Expressions for PP2Bcyto2nuc
reaction rate
J
((Kf * PP2Bcyto) - (Kr * PP2Bnuc)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
1.0 [1]
forward rate constant
Kf
0.0 [molecules.um-2.s-1.uM-1]
reverse rate constant
Kr
0.0 [molecules.um-2.s-1.uM-1]
Expressions for PP1cyto_D3497cyto_PP2Bcyto_on
reaction rate
J
(((Kf * PP1cyto_D3497cyto) * PP2Bcyto) - (Kr * PP1cyto_D3497cyto_PP2Bcyto)) [uM.s-1]
forward rate constant
Kf
D34_PP2B_kon [s-1.uM-1]
global
D34_PP2B_kon
4.1 [uM-1.s-1]
reverse rate constant
Kr
0.0 [s-1]
Expressions for PP1nuc_D34nuc_PP2Bnuc_on
reaction rate
J
(((Kf * PP1nuc_D34nuc) * PP2Bnuc) - (Kr * PP1nuc_D34nuc_PP2Bnuc)) [uM.s-1]
forward rate constant
Kf
D34_PP2B_kon [s-1.uM-1]
global
D34_PP2B_kon
4.1 [uM-1.s-1]
reverse rate constant
Kr
0.0 [s-1]
Expressions for D97nuc_PP2Apnuc_on
reaction rate
J
(((Kf * PP2Apnuc) * D97nuc) - (Kr * D97nuc_PP2Apnuc)) [uM.s-1]
forward rate constant
Kf
D97_PP2Ap_kon [s-1.uM-1]
global
D97_PP2Ap_kon
2.7 [uM-1.s-1]
reverse rate constant
Kr
0.0 [s-1]
Expressions for D34cyto2nuc
reaction rate
J
((Kf * D34cyto) - (Kr * D34nuc)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
1.0 [1]
forward rate constant
Kf
kDcyto2nuc [molecules.um-2.s-1.uM-1]
global
kDcyto2nuc
80.0 [molecules.um-2.uM-1.s-1]
reverse rate constant
Kr
0.0 [molecules.um-2.s-1.uM-1]
Expressions for PP2Acyto2nuc
reaction rate
J
((Kf * PP2Acyto) - (Kr * PP2Anuc)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
1.0 [1]
forward rate constant
Kf
0.0 [molecules.um-2.s-1.uM-1]
reverse rate constant
Kr
0.0 [molecules.um-2.s-1.uM-1]
Expressions for PP1cyto_D3497cyto_PP2Bcyto_off
reaction rate
J
((Kf * PP1cyto_D3497cyto_PP2Bcyto) - ((Kr * PP1cyto_D3497cyto) * PP2Bcyto)) [uM.s-1]
forward rate constant
Kf
D34_PP2B_koff [s-1]
global
D34_PP2B_koff
6.4 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-1]
Expressions for PP1nuc2cyto
reaction rate
J
((Kf * PP1nuc) - (Kr * PP1cyto)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
1.0 [1]
forward rate constant
Kf
0.0 [molecules.um-2.s-1.uM-1]
reverse rate constant
Kr
0.0 [molecules.um-2.s-1.uM-1]
Expressions for D97cyto2nuc_passive
reaction rate
J
((Kf * D97cyto) - (Kr * D97nuc)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
1.0 [1]
forward rate constant
Kf
kDcyto2nuc_passive [molecules.um-2.s-1.uM-1]
global
kDcyto2nuc
80.0 [molecules.um-2.uM-1.s-1]
global
kDcyto2nuc_passive
1.62 [molecules.um-2.uM-1.s-1]
reverse rate constant
Kr
0.0 [molecules.um-2.s-1.uM-1]
Expressions for cAMP_cAMP_R2C2_onoff
reaction rate
J
(((Kf * cAMP) * cAMP_R2C2) - (Kr * cAMP2_R2C2)) [uM.s-1]
forward rate constant
Kf
cAMP_cAMPR2C2_kon [s-1.uM-1]
global
cAMP_cAMPR2C2_kon
54.0 [uM-1.s-1]
reverse rate constant
Kr
cAMP_cAMPR2C2_koff [s-1]
global
cAMP_cAMPR2C2_koff
3.0 [s-1]
Expressions for PP1cyto_D3497cyto_cyto2nuc
reaction rate
J
((Kf * PP1cyto_D3497cyto) - (Kr * PP1nuc_D3497nuc)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
1.0 [1]
forward rate constant
Kf
kDcyto2nuc [molecules.um-2.s-1.uM-1]
global
kDcyto2nuc
80.0 [molecules.um-2.uM-1.s-1]
reverse rate constant
Kr
0.0 [molecules.um-2.s-1.uM-1]
Expressions for PP1nuc_D3497nuc_nuc2cyto
reaction rate
J
((Kf * PP1nuc_D3497nuc) - (Kr * PP1cyto_D3497cyto)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
1.0 [1]
forward rate constant
Kf
kD97nuc2cyto [molecules.um-2.s-1.uM-1]
global
kD97nuc2cyto
133.6313 [molecules.um-2.uM-1.s-1]
reverse rate constant
Kr
0.0 [molecules.um-2.s-1.uM-1]
Expressions for D34cyto_PP2Bcyto_cat
reaction rate
J
((Kf * D34cyto_PP2Bcyto) - ((Kr * Dcyto) * PP2Bcyto)) [uM.s-1]
forward rate constant
Kf
D34_PP2B_kcat [s-1]
global
D34_PP2B_kcat
0.1 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-1]
Expressions for D34cyto_PP2Bcyto_on
reaction rate
J
(((Kf * D34cyto) * PP2Bcyto) - (Kr * D34cyto_PP2Bcyto)) [uM.s-1]
forward rate constant
Kf
D34_PP2B_kon [s-1.uM-1]
global
D34_PP2B_kon
4.1 [uM-1.s-1]
reverse rate constant
Kr
0.0 [s-1]
Expressions for D3497nuc_PP2Bnuc_off
reaction rate
J
((Kf * D3497nuc_PP2Bnuc) - ((Kr * D3497nuc) * PP2Bnuc)) [uM.s-1]
forward rate constant
Kf
D34_PP2B_koff [s-1]
global
D34_PP2B_koff
6.4 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-1]
Expressions for D3497cyto2nuc_passive
reaction rate
J
((Kf * D3497cyto) - (Kr * D3497nuc)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
1.0 [1]
forward rate constant
Kf
kDcyto2nuc_passive [molecules.um-2.s-1.uM-1]
global
kDcyto2nuc
80.0 [molecules.um-2.uM-1.s-1]
global
kDcyto2nuc_passive
1.62 [molecules.um-2.uM-1.s-1]
reverse rate constant
Kr
0.0 [molecules.um-2.s-1.uM-1]
Expressions for D34nuc2cyto_passive
reaction rate
J
((Kf * D34nuc) - (Kr * D34cyto)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
1.0 [1]
forward rate constant
Kf
kDnuc2cyto_passive [molecules.um-2.s-1.uM-1]
global
kDnuc2cyto_passive
1.62 [molecules.um-2.uM-1.s-1]
reverse rate constant
Kr
0.0 [molecules.um-2.s-1.uM-1]
Expressions for D97cyto_PKAcyto_cyto2nuc
reaction rate
J
((Kf * D97cyto_PKAcyto) - (Kr * D97nuc_PKAnuc)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
1.0 [1]
forward rate constant
Kf
kDcyto2nuc [molecules.um-2.s-1.uM-1]
global
kDcyto2nuc
80.0 [molecules.um-2.uM-1.s-1]
reverse rate constant
Kr
0.0 [molecules.um-2.s-1.uM-1]
Expressions for D3497nuc_PP2Apnuc_off
reaction rate
J
((Kf * D3497nuc_PP2Apnuc) - ((Kr * PP2Apnuc) * D3497nuc)) [uM.s-1]
forward rate constant
Kf
D97_PP2Ap_koff [s-1]
global
D97_PP2Ap_koff
4.45 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-1]
Expressions for PP2Apnucdephosphorylation
reaction rate
J
((Kf * PP2Apnuc) - (Kr * PP2Anuc)) [uM.s-1]
forward rate constant
Kf
0.1 [s-1]
reverse rate constant
Kr
0.0 [s-1]
Expressions for PP1nuc_D3497nuc_on
reaction rate
J
(((Kf * D3497nuc) * PP1nuc) - (Kr * PP1nuc_D3497nuc)) [uM.s-1]
forward rate constant
Kf
PP1_D34_kon [s-1.uM-1]
global
PP1_D34_kon
40.0 [uM-1.s-1]
reverse rate constant
Kr
0.0 [s-1]
Expressions for D97cyto_PKAcyto_on
reaction rate
J
(((Kf * D97cyto) * PKAcyto) - (Kr * D97cyto_PKAcyto)) [uM.s-1]
forward rate constant
Kf
D_PKA_kon [s-1.uM-1]
global
D_PKA_kon
5.6 [uM-1.s-1]
reverse rate constant
Kr
0.0 [s-1]
Expressions for PP1cyto_D34cyto_on
reaction rate
J
(((Kf * PP1cyto) * D34cyto) - (Kr * PP1cyto_D34cyto)) [uM.s-1]
forward rate constant
Kf
PP1_D34_kon [s-1.uM-1]
global
PP1_D34_kon
40.0 [uM-1.s-1]
reverse rate constant
Kr
0.0 [s-1]
Expressions for D97cyto2nuc
reaction rate
J
((Kf * D97cyto) - (Kr * D97nuc)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
1.0 [1]
forward rate constant
Kf
kDcyto2nuc [molecules.um-2.s-1.uM-1]
global
kDcyto2nuc
80.0 [molecules.um-2.uM-1.s-1]
reverse rate constant
Kr
0.0 [molecules.um-2.s-1.uM-1]
Expressions for Dnuc_PKAnuc_off
reaction rate
J
((Kf * Dnuc_PKAnuc) - ((Kr * PKAnuc) * Dnuc)) [uM.s-1]
forward rate constant
Kf
D_PKA_koff [s-1]
global
D_PKA_koff
10.8 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-1]
Expressions for cAMP_cAMP3_R2C2_onoff
reaction rate
J
(((Kf * cAMP3_R2C2) * cAMP) - (Kr * cAMP4_R2C2)) [uM.s-1]
forward rate constant
Kf
cAMP_cAMP3R2C2_kon [s-1.uM-1]
global
cAMP_cAMP3R2C2_kon
75.0 [uM-1.s-1]
reverse rate constant
Kr
cAMP_cAMP3R2C2_koff [s-1]
global
cAMP_cAMP3R2C2_koff
110.0 [s-1]
Expressions for D3497cyto_PP2Apcyto_cyto2nuc
reaction rate
J
((Kf * D3497cyto_PP2Apcyto) - (Kr * D3497nuc_PP2Apnuc)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
1.0 [1]
forward rate constant
Kf
kDcyto2nuc [molecules.um-2.s-1.uM-1]
global
kDcyto2nuc
80.0 [molecules.um-2.uM-1.s-1]
reverse rate constant
Kr
0.0 [molecules.um-2.s-1.uM-1]
Expressions for D3497nuc_PP2Apnuc_nuc2cyto
reaction rate
J
((Kf * D3497nuc_PP2Apnuc) - (Kr * D3497cyto_PP2Apcyto)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
1.0 [1]
forward rate constant
Kf
kD97nuc2cyto [molecules.um-2.s-1.uM-1]
global
kD97nuc2cyto
133.6313 [molecules.um-2.uM-1.s-1]
reverse rate constant
Kr
0.0 [molecules.um-2.s-1.uM-1]
Expressions for D97cyto_PKAcyto_cat
reaction rate
J
((Kf * D97cyto_PKAcyto) - ((Kr * D3497cyto) * PKAcyto)) [uM.s-1]
forward rate constant
Kf
D_PKA_kcat [s-1]
global
D_PKA_kcat
2.7 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-1]
Expressions for D97nuc_PKAnuc_off
reaction rate
J
((Kf * D97nuc_PKAnuc) - ((Kr * D97nuc) * PKAnuc)) [uM.s-1]
forward rate constant
Kf
D_PKA_koff [s-1]
global
D_PKA_koff
10.8 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-1]
Expressions for cAMP_PDE10A_onoff
reaction rate
J
(((Kf * cAMP) * PDE10A) - (Kr * cAMP_PDE10A)) [uM.s-1]
forward rate constant
Kf
cAMP_PDE10A_kon [s-1.uM-1]
global
cAMP_PDE10A_kon
80.0 [uM-1.s-1]
reverse rate constant
Kr
cAMP_PDE10A_koff [s-1]
global
cAMP_PDE10A_koff
16.8 [s-1]
Structures
| Name | Type | Electrical |
|---|---|---|
| cellmembrane | Membrane | cytosol(+) c0(-) |
| nucleusmembrane | Membrane | nucleus(+) cytosol(-) |
| c0 | Compartment | (+) (-) |
| cytosol | Compartment | (+) (-) |
| nucleus | Compartment | (+) (-) |
cellmembrane Universal ID's
cellmembrane Text Annotations
nucleusmembrane Universal ID's
nucleusmembrane Text Annotations
c0 Universal ID's
c0 Text Annotations
cytosol Universal ID's
cytosol Text Annotations
nucleus Universal ID's
nucleus Text Annotations
Species
cAMPsource Universal ID's
cAMPsource Text Annotations
D3497cyto Universal ID's
D3497cyto Text Annotations
PP1cyto Universal ID's
PP1cyto Text Annotations
PP1cyto_D34cyto Universal ID's
PP1cyto_D34cyto Text Annotations
Dcyto Universal ID's
Dcyto Text Annotations
D97cyto_PP2Apcyto Universal ID's
D97cyto_PP2Apcyto Text Annotations
R2 Universal ID's
R2 Text Annotations
PP2Bcyto Universal ID's
PP2Bcyto Text Annotations
PP2Anuc Universal ID's
PP2Anuc Text Annotations
Dnuc_PKAnuc Universal ID's
Dnuc_PKAnuc Text Annotations
D97nuc_PP2Apnuc Universal ID's
D97nuc_PP2Apnuc Text Annotations
PP1cyto_D3497cyto_PP2Bcyto Universal ID's
PP1cyto_D3497cyto_PP2Bcyto Text Annotations
PDE10A Universal ID's
PDE10A Text Annotations
cAMP_PDE10A Universal ID's
cAMP_PDE10A Text Annotations
D97cyto_PKAcyto Universal ID's
D97cyto_PKAcyto Text Annotations
PP1cyto_D34cyto_PP2Bcyto Universal ID's
PP1cyto_D34cyto_PP2Bcyto Text Annotations
AMP Universal ID's
AMP Text Annotations
PP1nuc_D34nuc_PP2Bnuc Universal ID's
PP1nuc_D34nuc_PP2Bnuc Text Annotations
cAMP Universal ID's
cAMP Text Annotations
DMNB_cAMP Universal ID's
DMNB_cAMP Text Annotations
light_spot Universal ID's
light_spot Text Annotations
R2C Universal ID's
R2C Text Annotations
D34nuc_CK2 Universal ID's
D34nuc_CK2 Text Annotations
cAMP4_R2C2 Universal ID's
cAMP4_R2C2 Text Annotations
cAMP4_R2C Universal ID's
cAMP4_R2C Text Annotations
cAMP3_R2C2 Universal ID's
cAMP3_R2C2 Text Annotations
cAMP_R2C2 Universal ID's
cAMP_R2C2 Text Annotations
cAMP2_R2C2 Universal ID's
cAMP2_R2C2 Text Annotations
D34cyto_PP2Bcyto Universal ID's
D34cyto_PP2Bcyto Text Annotations
PKAcyto Universal ID's
PKAcyto Text Annotations
D3497cyto_PP2Apcyto Universal ID's
D3497cyto_PP2Apcyto Text Annotations
Dcyto_PKAcyto Universal ID's
Dcyto_PKAcyto Text Annotations
PP2Acyto_PKAcyto Universal ID's
PP2Acyto_PKAcyto Text Annotations
Dnuc_CK2 Universal ID's
Dnuc_CK2 Text Annotations
PP2Acyto Universal ID's
PP2Acyto Text Annotations
PP2Anuc_PKAnuc Universal ID's
PP2Anuc_PKAnuc Text Annotations
Dnuc Universal ID's
Dnuc Text Annotations
cAMP4_R2 Universal ID's
cAMP4_R2 Text Annotations
D34nuc_PP2Bnuc Universal ID's
D34nuc_PP2Bnuc Text Annotations
PP1nuc Universal ID's
PP1nuc Text Annotations
PP1nuc_D34nuc Universal ID's
PP1nuc_D34nuc Text Annotations
PP1nuc_D3497nuc Universal ID's
PP1nuc_D3497nuc Text Annotations
PP1nuc_D3497nuc_PP2Bnuc Universal ID's
PP1nuc_D3497nuc_PP2Bnuc Text Annotations
D3497nuc_PP2Apnuc Universal ID's
D3497nuc_PP2Apnuc Text Annotations
D97nuc Universal ID's
D97nuc Text Annotations
D3497nuc_PP2Bnuc Universal ID's
D3497nuc_PP2Bnuc Text Annotations
CK2 Universal ID's
CK2 Text Annotations
PP2Apcyto Universal ID's
PP2Apcyto Text Annotations
PP2Apnuc Universal ID's
PP2Apnuc Text Annotations
D97cyto Universal ID's
D97cyto Text Annotations
PP1cyto_D3497cyto Universal ID's
PP1cyto_D3497cyto Text Annotations
PP2Bnuc Universal ID's
PP2Bnuc Text Annotations
D34cyto Universal ID's
D34cyto Text Annotations
D34nuc Universal ID's
D34nuc Text Annotations
D3497nuc Universal ID's
D3497nuc Text Annotations
PKAnuc Universal ID's
PKAnuc Text Annotations
D97nuc_PKAnuc Universal ID's
D97nuc_PKAnuc Text Annotations
R2C2 Universal ID's
R2C2 Text Annotations
D3497cyto_PP2Bcyto Universal ID's
D3497cyto_PP2Bcyto Text Annotations
Applications
| Name | Properties | Math Type | Annotation |
|---|---|---|---|
| cAMPinput_tertiary3 |
Specs -
Species Specs - Reaction Simulations |
Deterministic (ODE) Spatial (3D) | NA |
| cAMPinput_secondary3 |
Specs -
Species Specs - Reaction Simulations |
Deterministic (ODE) Spatial (3D) | NA |
| cAMPinput_primary3 |
Specs -
Species Specs - Reaction Simulations |
Deterministic (ODE) Spatial (3D) | NA |
| cAMPinput_primary1 |
Specs -
Species Specs - Reaction Simulations |
Deterministic (ODE) Spatial (3D) | NA |
| cAMPinput_primary2 |
Specs -
Species Specs - Reaction Simulations |
Deterministic (ODE) Spatial (3D) | NA |
| cAMPinput_secondary1 |
Specs -
Species Specs - Reaction Simulations |
Deterministic (ODE) Spatial (3D) | NA |
| cAMPinput_secondary2 |
Specs -
Species Specs - Reaction Simulations |
Deterministic (ODE) Spatial (3D) | NA |
| cAMPinput_tertiary1 |
Specs -
Species Specs - Reaction Simulations |
Deterministic (ODE) Spatial (3D) | NA |
| cAMPinput_tertiary2 |
Specs -
Species Specs - Reaction Simulations |
Deterministic (ODE) Spatial (3D) | NA |
cAMPinput_tertiary3 Universal ID's
cAMPinput_tertiary3 Text Annotations
cAMPinput_secondary3 Universal ID's
cAMPinput_secondary3 Text Annotations
cAMPinput_primary3 Universal ID's
cAMPinput_primary3 Text Annotations
cAMPinput_primary1 Universal ID's
cAMPinput_primary1 Text Annotations
cAMPinput_primary2 Universal ID's
cAMPinput_primary2 Text Annotations
cAMPinput_secondary1 Universal ID's
cAMPinput_secondary1 Text Annotations
cAMPinput_secondary2 Universal ID's
cAMPinput_secondary2 Text Annotations
cAMPinput_tertiary1 Universal ID's
cAMPinput_tertiary1 Text Annotations
cAMPinput_tertiary2 Universal ID's
cAMPinput_tertiary2 Text Annotations
Specifications (Species) - cAMPinput_tertiary3 go to Simulations
| Species | Initial Condition | Diffusion Constant | Structure |
|---|---|---|---|
| cAMPsource | (200.0 * (t < 5.0) * (((x >= 150.0) && (x <= 151.8) && (y >= - 12.0) && (y <= - 10.5) && (z >= 5.0) && (z <= 6.0)) + ((x >= 152.0) && (x <= 152.5) && (y >= - 12.0) && (y <= - 10.5) && (z >= 5.0) && (z <= 5.5)))) [uM] | 0.0 [um2/s] | cytosol |
| D3497cyto | 0.0 [uM] | D_d32 [um2/s] | cytosol |
| PP1cyto | 5.0 [uM] | D_pp1 [um2/s] | cytosol |
| PP1cyto_D34cyto | 0.0 [uM] | D_d32pp1 [um2/s] | cytosol |
| Dcyto | 0.0 [uM] | D_d32 [um2/s] | cytosol |
| D97cyto_PP2Apcyto | 0.0 [uM] | D_d32pp2a [um2/s] | cytosol |
| R2 | 0.0 [uM] | D_r2 [um2/s] | cytosol |
| PP2Bcyto | 1.6 [uM] | D_pp2b [um2/s] | cytosol |
| PP1cyto_D3497cyto_PP2Bcyto | 0.0 [uM] | D_d32pp1pp2b [um2/s] | cytosol |
| PDE10A | 1.0 [uM] | D_pde10a [um2/s] | cytosol |
| cAMP_PDE10A | 0.0 [uM] | D_pde10a [um2/s] | cytosol |
| D97cyto_PKAcyto | 0.0 [uM] | D_d32pkac [um2/s] | cytosol |
| PP1cyto_D34cyto_PP2Bcyto | 0.0 [uM] | D_d32pp1pp2b [um2/s] | cytosol |
| AMP | 0.0 [uM] | 0.0 [um2/s] | cytosol |
| cAMP | 0.0 [uM] | 100.0 [um2/s] | cytosol |
| DMNB_cAMP | 0.0 [uM] | 100.0 [um2/s] | cytosol |
| light_spot | 0.0 [uM] | 0.0 [um2/s] | cytosol |
| R2C | 0.0 [uM] | D_r2c [um2/s] | cytosol |
| cAMP4_R2C2 | 0.0 [uM] | D_r2c2 [um2/s] | cytosol |
| cAMP4_R2C | 0.0 [uM] | D_r2c [um2/s] | cytosol |
| cAMP3_R2C2 | 0.0 [uM] | D_r2c2 [um2/s] | cytosol |
| cAMP_R2C2 | 0.0 [uM] | D_r2c2 [um2/s] | cytosol |
| cAMP2_R2C2 | 0.0 [uM] | D_r2c2 [um2/s] | cytosol |
| D34cyto_PP2Bcyto | 0.0 [uM] | D_d32pp2b [um2/s] | cytosol |
| PKAcyto | 0.0 [uM] | D_pkac [um2/s] | cytosol |
| D3497cyto_PP2Apcyto | 0.0 [uM] | D_d32pp2a [um2/s] | cytosol |
| Dcyto_PKAcyto | 0.0 [uM] | D_d32pkac [um2/s] | cytosol |
| PP2Acyto_PKAcyto | 0.0 [uM] | D_pp2apka [um2/s] | cytosol |
| PP2Acyto | 2.0 [uM] | D_pp2a [um2/s] | cytosol |
| cAMP4_R2 | 0.0 [uM] | D_r2 [um2/s] | cytosol |
| PP2Apcyto | 0.0 [uM] | D_pp2a [um2/s] | cytosol |
| D97cyto | 50.0 [uM] | D_d32 [um2/s] | cytosol |
| PP1cyto_D3497cyto | 0.0 [uM] | D_d32pp1 [um2/s] | cytosol |
| D34cyto | 0.0 [uM] | D_d32 [um2/s] | cytosol |
| R2C2 | 1.0 [uM] | D_r2c2 [um2/s] | cytosol |
| D3497cyto_PP2Bcyto | 0.0 [uM] | D_d32pp2b [um2/s] | cytosol |
| PP2Anuc | 2.0 [uM] | D_pp2a [um2/s] | nucleus |
| Dnuc_PKAnuc | 0.0 [uM] | D_d32pkac [um2/s] | nucleus |
| D97nuc_PP2Apnuc | 0.0 [uM] | D_d32pp2a [um2/s] | nucleus |
| PP1nuc_D34nuc_PP2Bnuc | 0.0 [uM] | D_d32pp1pp2b [um2/s] | nucleus |
| D34nuc_CK2 | 0.0 [uM] | D_d32ck2 [um2/s] | nucleus |
| Dnuc_CK2 | 0.0 [uM] | D_d32ck2 [um2/s] | nucleus |
| PP2Anuc_PKAnuc | 0.0 [uM] | D_pp2apka [um2/s] | nucleus |
| Dnuc | 0.0 [uM] | D_d32 [um2/s] | nucleus |
| D34nuc_PP2Bnuc | 0.0 [uM] | D_d32pp2b [um2/s] | nucleus |
| PP1nuc | 5.0 [uM] | D_pp1 [um2/s] | nucleus |
| PP1nuc_D34nuc | 0.0 [uM] | D_d32pp1 [um2/s] | nucleus |
| PP1nuc_D3497nuc | 0.0 [uM] | D_d32pp1 [um2/s] | nucleus |
| PP1nuc_D3497nuc_PP2Bnuc | 0.0 [uM] | D_d32pp1pp2b [um2/s] | nucleus |
| D3497nuc_PP2Apnuc | 0.0 [uM] | D_d32pp2a [um2/s] | nucleus |
| D97nuc | 30.0 [uM] | D_d32 [um2/s] | nucleus |
| D3497nuc_PP2Bnuc | 0.0 [uM] | D_d32pp2b [um2/s] | nucleus |
| CK2 | 1.0 [uM] | D_ck2 [um2/s] | nucleus |
| PP2Apnuc | 0.0 [uM] | D_pp2a [um2/s] | nucleus |
| PP2Bnuc | 1.6 [uM] | D_pp2b [um2/s] | nucleus |
| D34nuc | 0.0 [uM] | D_d32 [um2/s] | nucleus |
| D3497nuc | 0.0 [uM] | D_d32 [um2/s] | nucleus |
| PKAnuc | 0.0 [uM] | D_pkac [um2/s] | nucleus |
| D97nuc_PKAnuc | 0.0 [uM] | D_d32pkac [um2/s] | nucleus |
Specifications (Reaction) - cAMPinput_tertiary3 go to Simulations
| Name | Enabled? |
|---|---|
| PP1nuc_D34nuc_off | included |
| D3497cyto_PP2Bcyto_off | included |
| PP1nuc_D3497nuc_off | included |
| PP1cyto_D34cyto_PP2Bcyto_cyto2nuc | included |
| PP2Apcyto2nuc | included |
| D97cyto_PKAcyto_off | included |
| PP1cyto_D3497cyto_PP2Bcyto_cyto2nuc | included |
| D97cyto_PP2Apcyto_off | included |
| D97nuc2cyto | included |
| D3497cyto_PP2Apcyto_on | included |
| Dcyto2nuc_passive | included |
| D34cyto2nuc_passive | included |
| D3497cyto_PP2Bcyto_on | included |
| PP1nuc_D34nuc_nuc2cyto | included |
| Dnuc_CK2_cat | included |
| D3497nuc2cyto | included |
| D97nuc_PKAnuc_cat | included |
| PP2Anuc_PKAnuc_cat | included |
| D97nuc_PP2Apnuc_cat | included |
| PP1nuc_D3497nuc_PP2Bnuc_cat | included |
| PP1nuc_D3497nuc_PP2Bnuc_off | included |
| PP1cyto_D34cyto_PP2Bcyto_cat | included |
| D3497cyto2nuc | included |
| D3497nuc2cyto_passive | included |
| D3497nuc_PP2Bnuc_on | included |
| PP2Anuc2cyto | included |
| PP2Acyto_PKAcyto_cat | included |
| PP2Acyto_PKAcyto_off | included |
| D34nuc_CK2_cat | included |
| Dnuc2cyto_passive | included |
| Dnuc_CK2_off | included |
| photoUncaging_DMNB_cAMP | included |
| Dcyto_PKAcyto_on | included |
| Dnuc_PKAnuc_cat | included |
| D97nuc_PKAnuc_on | included |
| D3497cyto_PP2Bcyto_cyto2nuc | included |
| PP1cyto_D34cyto_PP2Bcyto_on | included |
| D34nuc_PP2Bnuc_on | included |
| R2_PKAcyto_bind | included |
| Dcyto_PKAcyto_off | included |
| D3497cyto_PP2Apcyto_cat | included |
| PP2Anuc_PKAnuc_on | included |
| PP2Bnuc2cyto | included |
| PP2Acyto_PKAcyto_on | included |
| PP1nuc_D3497nuc_PP2Bnuc_on | included |
| R2C_PKAcyto_bind | included |
| PP1cyto_D3497_off | included |
| D3497cyto_PP2Bcyto_cat | included |
| PP1nuc_D34nuc_PP2Bnuc_cat | included |
| PP1nuc_D34nuc_on | included |
| Dcyto_PKAcyto_cat | included |
| PP1cyto_D34cyto_PP2Bcyto_off | included |
| D97cyto_PP2Apcyto_cyto2nuc | included |
| Dnuc_CK2_on | included |
| PP1cyto_D34cyto_cyto2nuc | included |
| D3497nuc_PP2Bnuc_nuc2cyto | included |
| D3497nuc_PP2Apnuc_cat | included |
| D34nuc_PP2Bnuc_cat | included |
| Dcyto2nuc | included |
| cAMPsource2cAMP | included |
| D97nuc_PKAnuc_nuc2cyto | included |
| cAMP_PDE10A_cat | included |
| PP1cyto_D34cyto_off | included |
| PKAnuc2cyto | included |
| D3497nuc_PP2Apnuc_on | included |
| Dnuc_PKAnuc_on | included |
| D34cyto_PP2Bcyto_off | included |
| D3497cyto_PP2Apcyto_off | included |
| PP1cyto2nuc | included |
| D34nuc_CK2_off | included |
| PP1nuc_D34nuc_PP2Bnuc_off | included |
| PP1nuc_D3497nuc_PP2Bnuc_nuc2cyto | included |
| D97cyto_PP2Apcyto_on | included |
| cAMP4_R2_releasecAMP | included |
| PP2Anuc_PKAnuc_nuc2cyto | included |
| D34nuc_PP2Bnuc_off | included |
| D97cyto_PP2Apcyto_cat | included |
| PP1cyto_D3497cyto_PP2Bcyto_cat | included |
| cAMP_R2C2_onoff | included |
| D3497nuc_PP2Bnuc_cat | included |
| D34nuc_CK2_on | included |
| D97nuc_PP2Apnuc_off | included |
| D34cyto_PP2Bcyto_cyto2nuc | included |
| cAMP4_R2C_PKA_onoff | included |
| cAMP_cAMP2_R2C2_onoff | included |
| cAMP4_R2_PKA_onoff | included |
| D97nuc2cyto_passive | included |
| Dcyto_PKAcyto_cyto2nuc | included |
| PP2Apnuc2cyto | included |
| PP2Anuc_PKANuc_off | included |
| PKAcyto2nuc | included |
| PP2Acyto_PKAcyto_cyto2nuc | included |
| PP1cyto_D3497cyto_on | included |
| D97nuc_PP2Apnuc_nuc2cyto | included |
| PP2Apcytodephosphorylation | included |
| PP2Bcyto2nuc | included |
| PP1cyto_D3497cyto_PP2Bcyto_on | included |
| PP1nuc_D34nuc_PP2Bnuc_on | included |
| D97nuc_PP2Apnuc_on | included |
| D34cyto2nuc | included |
| PP2Acyto2nuc | included |
| PP1cyto_D3497cyto_PP2Bcyto_off | included |
| PP1nuc2cyto | included |
| D97cyto2nuc_passive | included |
| cAMP_cAMP_R2C2_onoff | included |
| PP1cyto_D3497cyto_cyto2nuc | included |
| PP1nuc_D3497nuc_nuc2cyto | included |
| D34cyto_PP2Bcyto_cat | included |
| D34cyto_PP2Bcyto_on | included |
| D3497nuc_PP2Bnuc_off | included |
| D3497cyto2nuc_passive | included |
| D34nuc2cyto_passive | included |
| D97cyto_PKAcyto_cyto2nuc | included |
| D3497nuc_PP2Apnuc_off | included |
| PP2Apnucdephosphorylation | included |
| PP1nuc_D3497nuc_on | included |
| D97cyto_PKAcyto_on | included |
| PP1cyto_D34cyto_on | included |
| D97cyto2nuc | included |
| Dnuc_PKAnuc_off | included |
| cAMP_cAMP3_R2C2_onoff | included |
| D3497cyto_PP2Apcyto_cyto2nuc | included |
| D3497nuc_PP2Apnuc_nuc2cyto | included |
| D97cyto_PKAcyto_cat | included |
| D97nuc_PKAnuc_off | included |
| cAMP_PDE10A_onoff | included |
Simulations - cAMPinput_tertiary3 go to Specifications
| Name | End Time | Output Options |
|---|---|---|
| cAMPtertiaryEnd | 3600.0 |
OutputTimeStep 5.0 |
cAMPinput_tertiary3 Universal ID's
cAMPinput_tertiary3 Text Annotations
Assignments
| Name | Variable | Assignment Function Expression |
|---|
Events
| Name | Trigger Type | Variable Assignment |
|---|
Geometry Geometry1760091997
(Origin: 0.0, -14.0, 0.0; Extent: 155.0, 40.0, 11.0 [um])
| Dimension | Type | Subdomain | Adjacent Subvolumes | Size | Mapped Compartment |
|---|---|---|---|---|---|
| Volume | Analytical | subdomain2 | 301.60068965661543 [um3] | nucleus | |
| Volume | Analytical | subdomain1 | 1202.1930494498022 [um3] | cytosol | |
| Volume | Analytical | subdomain0 | 66696.20626089358 [um3] | c0 | |
| Surface | subdomain0_subdomain1_membrane | subdomain0 | subdomain1 | 1432.4688299433924 [um2] | cellmembrane | |
| Surface | subdomain1_subdomain2_membrane | subdomain1 | subdomain2 | 211.84616618489457 [um2] | nucleusmembrane |
Events
| Name | Variable | Rate Expression |
|---|
Specifications (Species) - cAMPinput_secondary3 go to Simulations
| Species | Initial Condition | Diffusion Constant | Structure |
|---|---|---|---|
| cAMPsource | (200.0 * (t < 5.0) * ((x >= 90.0) && (x <= 91.8) && (y >= - 11.5) && (y <= - 10.0) && (z >= 5.0) && (z <= 5.5))) [uM] | 0.0 [um2/s] | cytosol |
| D3497cyto | 0.0 [uM] | D_d32 [um2/s] | cytosol |
| PP1cyto | 5.0 [uM] | D_pp1 [um2/s] | cytosol |
| PP1cyto_D34cyto | 0.0 [uM] | D_d32pp1 [um2/s] | cytosol |
| Dcyto | 0.0 [uM] | D_d32 [um2/s] | cytosol |
| D97cyto_PP2Apcyto | 0.0 [uM] | D_d32pp2a [um2/s] | cytosol |
| R2 | 0.0 [uM] | D_r2 [um2/s] | cytosol |
| PP2Bcyto | 1.6 [uM] | D_pp2b [um2/s] | cytosol |
| PP1cyto_D3497cyto_PP2Bcyto | 0.0 [uM] | D_d32pp1pp2b [um2/s] | cytosol |
| PDE10A | 1.0 [uM] | D_pde10a [um2/s] | cytosol |
| cAMP_PDE10A | 0.0 [uM] | D_pde10a [um2/s] | cytosol |
| D97cyto_PKAcyto | 0.0 [uM] | D_d32pkac [um2/s] | cytosol |
| PP1cyto_D34cyto_PP2Bcyto | 0.0 [uM] | D_d32pp1pp2b [um2/s] | cytosol |
| AMP | 0.0 [uM] | 0.0 [um2/s] | cytosol |
| cAMP | 0.0 [uM] | 100.0 [um2/s] | cytosol |
| DMNB_cAMP | 0.0 [uM] | 100.0 [um2/s] | cytosol |
| light_spot | 0.0 [uM] | 0.0 [um2/s] | cytosol |
| R2C | 0.0 [uM] | D_r2c [um2/s] | cytosol |
| cAMP4_R2C2 | 0.0 [uM] | D_r2c2 [um2/s] | cytosol |
| cAMP4_R2C | 0.0 [uM] | D_r2c [um2/s] | cytosol |
| cAMP3_R2C2 | 0.0 [uM] | D_r2c2 [um2/s] | cytosol |
| cAMP_R2C2 | 0.0 [uM] | D_r2c2 [um2/s] | cytosol |
| cAMP2_R2C2 | 0.0 [uM] | D_r2c2 [um2/s] | cytosol |
| D34cyto_PP2Bcyto | 0.0 [uM] | D_d32pp2b [um2/s] | cytosol |
| PKAcyto | 0.0 [uM] | D_pkac [um2/s] | cytosol |
| D3497cyto_PP2Apcyto | 0.0 [uM] | D_d32pp2a [um2/s] | cytosol |
| Dcyto_PKAcyto | 0.0 [uM] | D_d32pkac [um2/s] | cytosol |
| PP2Acyto_PKAcyto | 0.0 [uM] | D_pp2apka [um2/s] | cytosol |
| PP2Acyto | 2.0 [uM] | D_pp2a [um2/s] | cytosol |
| cAMP4_R2 | 0.0 [uM] | D_r2 [um2/s] | cytosol |
| PP2Apcyto | 0.0 [uM] | D_pp2a [um2/s] | cytosol |
| D97cyto | 50.0 [uM] | D_d32 [um2/s] | cytosol |
| PP1cyto_D3497cyto | 0.0 [uM] | D_d32pp1 [um2/s] | cytosol |
| D34cyto | 0.0 [uM] | D_d32 [um2/s] | cytosol |
| R2C2 | 1.0 [uM] | D_r2c2 [um2/s] | cytosol |
| D3497cyto_PP2Bcyto | 0.0 [uM] | D_d32pp2b [um2/s] | cytosol |
| PP2Anuc | 2.0 [uM] | D_pp2a [um2/s] | nucleus |
| Dnuc_PKAnuc | 0.0 [uM] | D_d32pkac [um2/s] | nucleus |
| D97nuc_PP2Apnuc | 0.0 [uM] | D_d32pp2a [um2/s] | nucleus |
| PP1nuc_D34nuc_PP2Bnuc | 0.0 [uM] | D_d32pp1pp2b [um2/s] | nucleus |
| D34nuc_CK2 | 0.0 [uM] | D_d32ck2 [um2/s] | nucleus |
| Dnuc_CK2 | 0.0 [uM] | D_d32ck2 [um2/s] | nucleus |
| PP2Anuc_PKAnuc | 0.0 [uM] | D_pp2apka [um2/s] | nucleus |
| Dnuc | 0.0 [uM] | D_d32 [um2/s] | nucleus |
| D34nuc_PP2Bnuc | 0.0 [uM] | D_d32pp2b [um2/s] | nucleus |
| PP1nuc | 5.0 [uM] | D_pp1 [um2/s] | nucleus |
| PP1nuc_D34nuc | 0.0 [uM] | D_d32pp1 [um2/s] | nucleus |
| PP1nuc_D3497nuc | 0.0 [uM] | D_d32pp1 [um2/s] | nucleus |
| PP1nuc_D3497nuc_PP2Bnuc | 0.0 [uM] | D_d32pp1pp2b [um2/s] | nucleus |
| D3497nuc_PP2Apnuc | 0.0 [uM] | D_d32pp2a [um2/s] | nucleus |
| D97nuc | 30.0 [uM] | D_d32 [um2/s] | nucleus |
| D3497nuc_PP2Bnuc | 0.0 [uM] | D_d32pp2b [um2/s] | nucleus |
| CK2 | 1.0 [uM] | D_ck2 [um2/s] | nucleus |
| PP2Apnuc | 0.0 [uM] | D_pp2a [um2/s] | nucleus |
| PP2Bnuc | 1.6 [uM] | D_pp2b [um2/s] | nucleus |
| D34nuc | 0.0 [uM] | D_d32 [um2/s] | nucleus |
| D3497nuc | 0.0 [uM] | D_d32 [um2/s] | nucleus |
| PKAnuc | 0.0 [uM] | D_pkac [um2/s] | nucleus |
| D97nuc_PKAnuc | 0.0 [uM] | D_d32pkac [um2/s] | nucleus |
Specifications (Reaction) - cAMPinput_secondary3 go to Simulations
| Name | Enabled? |
|---|---|
| PP1nuc_D34nuc_off | included |
| D3497cyto_PP2Bcyto_off | included |
| PP1nuc_D3497nuc_off | included |
| PP1cyto_D34cyto_PP2Bcyto_cyto2nuc | included |
| PP2Apcyto2nuc | included |
| D97cyto_PKAcyto_off | included |
| PP1cyto_D3497cyto_PP2Bcyto_cyto2nuc | included |
| D97cyto_PP2Apcyto_off | included |
| D97nuc2cyto | included |
| D3497cyto_PP2Apcyto_on | included |
| Dcyto2nuc_passive | included |
| D34cyto2nuc_passive | included |
| D3497cyto_PP2Bcyto_on | included |
| PP1nuc_D34nuc_nuc2cyto | included |
| Dnuc_CK2_cat | included |
| D3497nuc2cyto | included |
| D97nuc_PKAnuc_cat | included |
| PP2Anuc_PKAnuc_cat | included |
| D97nuc_PP2Apnuc_cat | included |
| PP1nuc_D3497nuc_PP2Bnuc_cat | included |
| PP1nuc_D3497nuc_PP2Bnuc_off | included |
| PP1cyto_D34cyto_PP2Bcyto_cat | included |
| D3497cyto2nuc | included |
| D3497nuc2cyto_passive | included |
| D3497nuc_PP2Bnuc_on | included |
| PP2Anuc2cyto | included |
| PP2Acyto_PKAcyto_cat | included |
| PP2Acyto_PKAcyto_off | included |
| D34nuc_CK2_cat | included |
| Dnuc2cyto_passive | included |
| Dnuc_CK2_off | included |
| photoUncaging_DMNB_cAMP | included |
| Dcyto_PKAcyto_on | included |
| Dnuc_PKAnuc_cat | included |
| D97nuc_PKAnuc_on | included |
| D3497cyto_PP2Bcyto_cyto2nuc | included |
| PP1cyto_D34cyto_PP2Bcyto_on | included |
| D34nuc_PP2Bnuc_on | included |
| R2_PKAcyto_bind | included |
| Dcyto_PKAcyto_off | included |
| D3497cyto_PP2Apcyto_cat | included |
| PP2Anuc_PKAnuc_on | included |
| PP2Bnuc2cyto | included |
| PP2Acyto_PKAcyto_on | included |
| PP1nuc_D3497nuc_PP2Bnuc_on | included |
| R2C_PKAcyto_bind | included |
| PP1cyto_D3497_off | included |
| D3497cyto_PP2Bcyto_cat | included |
| PP1nuc_D34nuc_PP2Bnuc_cat | included |
| PP1nuc_D34nuc_on | included |
| Dcyto_PKAcyto_cat | included |
| PP1cyto_D34cyto_PP2Bcyto_off | included |
| D97cyto_PP2Apcyto_cyto2nuc | included |
| Dnuc_CK2_on | included |
| PP1cyto_D34cyto_cyto2nuc | included |
| D3497nuc_PP2Bnuc_nuc2cyto | included |
| D3497nuc_PP2Apnuc_cat | included |
| D34nuc_PP2Bnuc_cat | included |
| Dcyto2nuc | included |
| cAMPsource2cAMP | included |
| D97nuc_PKAnuc_nuc2cyto | included |
| cAMP_PDE10A_cat | included |
| PP1cyto_D34cyto_off | included |
| PKAnuc2cyto | included |
| D3497nuc_PP2Apnuc_on | included |
| Dnuc_PKAnuc_on | included |
| D34cyto_PP2Bcyto_off | included |
| D3497cyto_PP2Apcyto_off | included |
| PP1cyto2nuc | included |
| D34nuc_CK2_off | included |
| PP1nuc_D34nuc_PP2Bnuc_off | included |
| PP1nuc_D3497nuc_PP2Bnuc_nuc2cyto | included |
| D97cyto_PP2Apcyto_on | included |
| cAMP4_R2_releasecAMP | included |
| PP2Anuc_PKAnuc_nuc2cyto | included |
| D34nuc_PP2Bnuc_off | included |
| D97cyto_PP2Apcyto_cat | included |
| PP1cyto_D3497cyto_PP2Bcyto_cat | included |
| cAMP_R2C2_onoff | included |
| D3497nuc_PP2Bnuc_cat | included |
| D34nuc_CK2_on | included |
| D97nuc_PP2Apnuc_off | included |
| D34cyto_PP2Bcyto_cyto2nuc | included |
| cAMP4_R2C_PKA_onoff | included |
| cAMP_cAMP2_R2C2_onoff | included |
| cAMP4_R2_PKA_onoff | included |
| D97nuc2cyto_passive | included |
| Dcyto_PKAcyto_cyto2nuc | included |
| PP2Apnuc2cyto | included |
| PP2Anuc_PKANuc_off | included |
| PKAcyto2nuc | included |
| PP2Acyto_PKAcyto_cyto2nuc | included |
| PP1cyto_D3497cyto_on | included |
| D97nuc_PP2Apnuc_nuc2cyto | included |
| PP2Apcytodephosphorylation | included |
| PP2Bcyto2nuc | included |
| PP1cyto_D3497cyto_PP2Bcyto_on | included |
| PP1nuc_D34nuc_PP2Bnuc_on | included |
| D97nuc_PP2Apnuc_on | included |
| D34cyto2nuc | included |
| PP2Acyto2nuc | included |
| PP1cyto_D3497cyto_PP2Bcyto_off | included |
| PP1nuc2cyto | included |
| D97cyto2nuc_passive | included |
| cAMP_cAMP_R2C2_onoff | included |
| PP1cyto_D3497cyto_cyto2nuc | included |
| PP1nuc_D3497nuc_nuc2cyto | included |
| D34cyto_PP2Bcyto_cat | included |
| D34cyto_PP2Bcyto_on | included |
| D3497nuc_PP2Bnuc_off | included |
| D3497cyto2nuc_passive | included |
| D34nuc2cyto_passive | included |
| D97cyto_PKAcyto_cyto2nuc | included |
| D3497nuc_PP2Apnuc_off | included |
| PP2Apnucdephosphorylation | included |
| PP1nuc_D3497nuc_on | included |
| D97cyto_PKAcyto_on | included |
| PP1cyto_D34cyto_on | included |
| D97cyto2nuc | included |
| Dnuc_PKAnuc_off | included |
| cAMP_cAMP3_R2C2_onoff | included |
| D3497cyto_PP2Apcyto_cyto2nuc | included |
| D3497nuc_PP2Apnuc_nuc2cyto | included |
| D97cyto_PKAcyto_cat | included |
| D97nuc_PKAnuc_off | included |
| cAMP_PDE10A_onoff | included |
Simulations - cAMPinput_secondary3 go to Specifications
| Name | End Time | Output Options |
|---|---|---|
| cAMPsecondaryEnd | 3600.0 |
OutputTimeStep 5.0 |
cAMPinput_secondary3 Universal ID's
cAMPinput_secondary3 Text Annotations
Assignments
| Name | Variable | Assignment Function Expression |
|---|
Events
| Name | Trigger Type | Variable Assignment |
|---|
Geometry Geometry1760091997
(Origin: 0.0, -14.0, 0.0; Extent: 155.0, 40.0, 11.0 [um])
| Dimension | Type | Subdomain | Adjacent Subvolumes | Size | Mapped Compartment |
|---|---|---|---|---|---|
| Volume | Analytical | subdomain2 | 301.60068965661543 [um3] | nucleus | |
| Volume | Analytical | subdomain1 | 1202.1930494498022 [um3] | cytosol | |
| Volume | Analytical | subdomain0 | 66696.20626089358 [um3] | c0 | |
| Surface | subdomain0_subdomain1_membrane | subdomain0 | subdomain1 | 1432.4688299433924 [um2] | cellmembrane | |
| Surface | subdomain1_subdomain2_membrane | subdomain1 | subdomain2 | 211.84616618489457 [um2] | nucleusmembrane |
Events
| Name | Variable | Rate Expression |
|---|
Specifications (Species) - cAMPinput_primary3 go to Simulations
| Species | Initial Condition | Diffusion Constant | Structure |
|---|---|---|---|
| cAMPsource | (200.0 * (t < 5.0) * ((x >= 43.5) && (x <= 45.3) && (y >= 4.5) && (y <= 5.5) && (z >= 5.0) && (z <= 5.5))) [uM] | 0.0 [um2/s] | cytosol |
| D3497cyto | 0.0 [uM] | D_d32 [um2/s] | cytosol |
| PP1cyto | 5.0 [uM] | D_pp1 [um2/s] | cytosol |
| PP1cyto_D34cyto | 0.0 [uM] | D_d32pp1 [um2/s] | cytosol |
| Dcyto | 0.0 [uM] | D_d32 [um2/s] | cytosol |
| D97cyto_PP2Apcyto | 0.0 [uM] | D_d32pp2a [um2/s] | cytosol |
| R2 | 0.0 [uM] | D_r2 [um2/s] | cytosol |
| PP2Bcyto | 1.6 [uM] | D_pp2b [um2/s] | cytosol |
| PP1cyto_D3497cyto_PP2Bcyto | 0.0 [uM] | D_d32pp1pp2b [um2/s] | cytosol |
| PDE10A | 1.0 [uM] | D_pde10a [um2/s] | cytosol |
| cAMP_PDE10A | 0.0 [uM] | D_pde10a [um2/s] | cytosol |
| D97cyto_PKAcyto | 0.0 [uM] | D_d32pkac [um2/s] | cytosol |
| PP1cyto_D34cyto_PP2Bcyto | 0.0 [uM] | D_d32pp1pp2b [um2/s] | cytosol |
| AMP | 0.0 [uM] | 0.0 [um2/s] | cytosol |
| cAMP | 0.0 [uM] | 100.0 [um2/s] | cytosol |
| DMNB_cAMP | 0.0 [uM] | 100.0 [um2/s] | cytosol |
| light_spot | 0.0 [uM] | 0.0 [um2/s] | cytosol |
| R2C | 0.0 [uM] | D_r2c [um2/s] | cytosol |
| cAMP4_R2C2 | 0.0 [uM] | D_r2c2 [um2/s] | cytosol |
| cAMP4_R2C | 0.0 [uM] | D_r2c [um2/s] | cytosol |
| cAMP3_R2C2 | 0.0 [uM] | D_r2c2 [um2/s] | cytosol |
| cAMP_R2C2 | 0.0 [uM] | D_r2c2 [um2/s] | cytosol |
| cAMP2_R2C2 | 0.0 [uM] | D_r2c2 [um2/s] | cytosol |
| D34cyto_PP2Bcyto | 0.0 [uM] | D_d32pp2b [um2/s] | cytosol |
| PKAcyto | 0.0 [uM] | D_pkac [um2/s] | cytosol |
| D3497cyto_PP2Apcyto | 0.0 [uM] | D_d32pp2a [um2/s] | cytosol |
| Dcyto_PKAcyto | 0.0 [uM] | D_d32pkac [um2/s] | cytosol |
| PP2Acyto_PKAcyto | 0.0 [uM] | D_pp2apka [um2/s] | cytosol |
| PP2Acyto | 2.0 [uM] | D_pp2a [um2/s] | cytosol |
| cAMP4_R2 | 0.0 [uM] | D_r2 [um2/s] | cytosol |
| PP2Apcyto | 0.0 [uM] | D_pp2a [um2/s] | cytosol |
| D97cyto | 50.0 [uM] | D_d32 [um2/s] | cytosol |
| PP1cyto_D3497cyto | 0.0 [uM] | D_d32pp1 [um2/s] | cytosol |
| D34cyto | 0.0 [uM] | D_d32 [um2/s] | cytosol |
| R2C2 | 1.0 [uM] | D_r2c2 [um2/s] | cytosol |
| D3497cyto_PP2Bcyto | 0.0 [uM] | D_d32pp2b [um2/s] | cytosol |
| PP2Anuc | 2.0 [uM] | D_pp2a [um2/s] | nucleus |
| Dnuc_PKAnuc | 0.0 [uM] | D_d32pkac [um2/s] | nucleus |
| D97nuc_PP2Apnuc | 0.0 [uM] | D_d32pp2a [um2/s] | nucleus |
| PP1nuc_D34nuc_PP2Bnuc | 0.0 [uM] | D_d32pp1pp2b [um2/s] | nucleus |
| D34nuc_CK2 | 0.0 [uM] | D_d32ck2 [um2/s] | nucleus |
| Dnuc_CK2 | 0.0 [uM] | D_d32ck2 [um2/s] | nucleus |
| PP2Anuc_PKAnuc | 0.0 [uM] | D_pp2apka [um2/s] | nucleus |
| Dnuc | 0.0 [uM] | D_d32 [um2/s] | nucleus |
| D34nuc_PP2Bnuc | 0.0 [uM] | D_d32pp2b [um2/s] | nucleus |
| PP1nuc | 5.0 [uM] | D_pp1 [um2/s] | nucleus |
| PP1nuc_D34nuc | 0.0 [uM] | D_d32pp1 [um2/s] | nucleus |
| PP1nuc_D3497nuc | 0.0 [uM] | D_d32pp1 [um2/s] | nucleus |
| PP1nuc_D3497nuc_PP2Bnuc | 0.0 [uM] | D_d32pp1pp2b [um2/s] | nucleus |
| D3497nuc_PP2Apnuc | 0.0 [uM] | D_d32pp2a [um2/s] | nucleus |
| D97nuc | 30.0 [uM] | D_d32 [um2/s] | nucleus |
| D3497nuc_PP2Bnuc | 0.0 [uM] | D_d32pp2b [um2/s] | nucleus |
| CK2 | 1.0 [uM] | D_ck2 [um2/s] | nucleus |
| PP2Apnuc | 0.0 [uM] | D_pp2a [um2/s] | nucleus |
| PP2Bnuc | 1.6 [uM] | D_pp2b [um2/s] | nucleus |
| D34nuc | 0.0 [uM] | D_d32 [um2/s] | nucleus |
| D3497nuc | 0.0 [uM] | D_d32 [um2/s] | nucleus |
| PKAnuc | 0.0 [uM] | D_pkac [um2/s] | nucleus |
| D97nuc_PKAnuc | 0.0 [uM] | D_d32pkac [um2/s] | nucleus |
Specifications (Reaction) - cAMPinput_primary3 go to Simulations
| Name | Enabled? |
|---|---|
| PP1nuc_D34nuc_off | included |
| D3497cyto_PP2Bcyto_off | included |
| PP1nuc_D3497nuc_off | included |
| PP1cyto_D34cyto_PP2Bcyto_cyto2nuc | included |
| PP2Apcyto2nuc | included |
| D97cyto_PKAcyto_off | included |
| PP1cyto_D3497cyto_PP2Bcyto_cyto2nuc | included |
| D97cyto_PP2Apcyto_off | included |
| D97nuc2cyto | included |
| D3497cyto_PP2Apcyto_on | included |
| Dcyto2nuc_passive | included |
| D34cyto2nuc_passive | included |
| D3497cyto_PP2Bcyto_on | included |
| PP1nuc_D34nuc_nuc2cyto | included |
| Dnuc_CK2_cat | included |
| D3497nuc2cyto | included |
| D97nuc_PKAnuc_cat | included |
| PP2Anuc_PKAnuc_cat | included |
| D97nuc_PP2Apnuc_cat | included |
| PP1nuc_D3497nuc_PP2Bnuc_cat | included |
| PP1nuc_D3497nuc_PP2Bnuc_off | included |
| PP1cyto_D34cyto_PP2Bcyto_cat | included |
| D3497cyto2nuc | included |
| D3497nuc2cyto_passive | included |
| D3497nuc_PP2Bnuc_on | included |
| PP2Anuc2cyto | included |
| PP2Acyto_PKAcyto_cat | included |
| PP2Acyto_PKAcyto_off | included |
| D34nuc_CK2_cat | included |
| Dnuc2cyto_passive | included |
| Dnuc_CK2_off | included |
| photoUncaging_DMNB_cAMP | included |
| Dcyto_PKAcyto_on | included |
| Dnuc_PKAnuc_cat | included |
| D97nuc_PKAnuc_on | included |
| D3497cyto_PP2Bcyto_cyto2nuc | included |
| PP1cyto_D34cyto_PP2Bcyto_on | included |
| D34nuc_PP2Bnuc_on | included |
| R2_PKAcyto_bind | included |
| Dcyto_PKAcyto_off | included |
| D3497cyto_PP2Apcyto_cat | included |
| PP2Anuc_PKAnuc_on | included |
| PP2Bnuc2cyto | included |
| PP2Acyto_PKAcyto_on | included |
| PP1nuc_D3497nuc_PP2Bnuc_on | included |
| R2C_PKAcyto_bind | included |
| PP1cyto_D3497_off | included |
| D3497cyto_PP2Bcyto_cat | included |
| PP1nuc_D34nuc_PP2Bnuc_cat | included |
| PP1nuc_D34nuc_on | included |
| Dcyto_PKAcyto_cat | included |
| PP1cyto_D34cyto_PP2Bcyto_off | included |
| D97cyto_PP2Apcyto_cyto2nuc | included |
| Dnuc_CK2_on | included |
| PP1cyto_D34cyto_cyto2nuc | included |
| D3497nuc_PP2Bnuc_nuc2cyto | included |
| D3497nuc_PP2Apnuc_cat | included |
| D34nuc_PP2Bnuc_cat | included |
| Dcyto2nuc | included |
| cAMPsource2cAMP | included |
| D97nuc_PKAnuc_nuc2cyto | included |
| cAMP_PDE10A_cat | included |
| PP1cyto_D34cyto_off | included |
| PKAnuc2cyto | included |
| D3497nuc_PP2Apnuc_on | included |
| Dnuc_PKAnuc_on | included |
| D34cyto_PP2Bcyto_off | included |
| D3497cyto_PP2Apcyto_off | included |
| PP1cyto2nuc | included |
| D34nuc_CK2_off | included |
| PP1nuc_D34nuc_PP2Bnuc_off | included |
| PP1nuc_D3497nuc_PP2Bnuc_nuc2cyto | included |
| D97cyto_PP2Apcyto_on | included |
| cAMP4_R2_releasecAMP | included |
| PP2Anuc_PKAnuc_nuc2cyto | included |
| D34nuc_PP2Bnuc_off | included |
| D97cyto_PP2Apcyto_cat | included |
| PP1cyto_D3497cyto_PP2Bcyto_cat | included |
| cAMP_R2C2_onoff | included |
| D3497nuc_PP2Bnuc_cat | included |
| D34nuc_CK2_on | included |
| D97nuc_PP2Apnuc_off | included |
| D34cyto_PP2Bcyto_cyto2nuc | included |
| cAMP4_R2C_PKA_onoff | included |
| cAMP_cAMP2_R2C2_onoff | included |
| cAMP4_R2_PKA_onoff | included |
| D97nuc2cyto_passive | included |
| Dcyto_PKAcyto_cyto2nuc | included |
| PP2Apnuc2cyto | included |
| PP2Anuc_PKANuc_off | included |
| PKAcyto2nuc | included |
| PP2Acyto_PKAcyto_cyto2nuc | included |
| PP1cyto_D3497cyto_on | included |
| D97nuc_PP2Apnuc_nuc2cyto | included |
| PP2Apcytodephosphorylation | included |
| PP2Bcyto2nuc | included |
| PP1cyto_D3497cyto_PP2Bcyto_on | included |
| PP1nuc_D34nuc_PP2Bnuc_on | included |
| D97nuc_PP2Apnuc_on | included |
| D34cyto2nuc | included |
| PP2Acyto2nuc | included |
| PP1cyto_D3497cyto_PP2Bcyto_off | included |
| PP1nuc2cyto | included |
| D97cyto2nuc_passive | included |
| cAMP_cAMP_R2C2_onoff | included |
| PP1cyto_D3497cyto_cyto2nuc | included |
| PP1nuc_D3497nuc_nuc2cyto | included |
| D34cyto_PP2Bcyto_cat | included |
| D34cyto_PP2Bcyto_on | included |
| D3497nuc_PP2Bnuc_off | included |
| D3497cyto2nuc_passive | included |
| D34nuc2cyto_passive | included |
| D97cyto_PKAcyto_cyto2nuc | included |
| D3497nuc_PP2Apnuc_off | included |
| PP2Apnucdephosphorylation | included |
| PP1nuc_D3497nuc_on | included |
| D97cyto_PKAcyto_on | included |
| PP1cyto_D34cyto_on | included |
| D97cyto2nuc | included |
| Dnuc_PKAnuc_off | included |
| cAMP_cAMP3_R2C2_onoff | included |
| D3497cyto_PP2Apcyto_cyto2nuc | included |
| D3497nuc_PP2Apnuc_nuc2cyto | included |
| D97cyto_PKAcyto_cat | included |
| D97nuc_PKAnuc_off | included |
| cAMP_PDE10A_onoff | included |
Simulations - cAMPinput_primary3 go to Specifications
| Name | End Time | Output Options |
|---|---|---|
| cAMPprimaryEnd | 3600.0 |
OutputTimeStep 5.0 |
cAMPinput_primary3 Universal ID's
cAMPinput_primary3 Text Annotations
Assignments
| Name | Variable | Assignment Function Expression |
|---|
Events
| Name | Trigger Type | Variable Assignment |
|---|
Geometry Geometry1760091997
(Origin: 0.0, -14.0, 0.0; Extent: 155.0, 40.0, 11.0 [um])
| Dimension | Type | Subdomain | Adjacent Subvolumes | Size | Mapped Compartment |
|---|---|---|---|---|---|
| Volume | Analytical | subdomain2 | 301.60068965661543 [um3] | nucleus | |
| Volume | Analytical | subdomain1 | 1202.1930494498022 [um3] | cytosol | |
| Volume | Analytical | subdomain0 | 66696.20626089358 [um3] | c0 | |
| Surface | subdomain0_subdomain1_membrane | subdomain0 | subdomain1 | 1432.4688299433924 [um2] | cellmembrane | |
| Surface | subdomain1_subdomain2_membrane | subdomain1 | subdomain2 | 211.84616618489457 [um2] | nucleusmembrane |
Events
| Name | Variable | Rate Expression |
|---|
Specifications (Species) - cAMPinput_primary1 go to Simulations
| Species | Initial Condition | Diffusion Constant | Structure |
|---|---|---|---|
| cAMPsource | (200.0 * (t < 5.0) * ((x >= 20.5) && (x <= 22.3) && (y >= 4.5) && (y <= 5.5) && (z >= 5.0) && (z <= 5.5))) [uM] | 0.0 [um2/s] | cytosol |
| D3497cyto | 0.0 [uM] | D_d32 [um2/s] | cytosol |
| PP1cyto | 5.0 [uM] | D_pp1 [um2/s] | cytosol |
| PP1cyto_D34cyto | 0.0 [uM] | D_d32pp1 [um2/s] | cytosol |
| Dcyto | 0.0 [uM] | D_d32 [um2/s] | cytosol |
| D97cyto_PP2Apcyto | 0.0 [uM] | D_d32pp2a [um2/s] | cytosol |
| R2 | 0.0 [uM] | D_r2 [um2/s] | cytosol |
| PP2Bcyto | 1.6 [uM] | D_pp2b [um2/s] | cytosol |
| PP1cyto_D3497cyto_PP2Bcyto | 0.0 [uM] | D_d32pp1pp2b [um2/s] | cytosol |
| PDE10A | 1.0 [uM] | D_pde10a [um2/s] | cytosol |
| cAMP_PDE10A | 0.0 [uM] | D_pde10a [um2/s] | cytosol |
| D97cyto_PKAcyto | 0.0 [uM] | D_d32pkac [um2/s] | cytosol |
| PP1cyto_D34cyto_PP2Bcyto | 0.0 [uM] | D_d32pp1pp2b [um2/s] | cytosol |
| AMP | 0.0 [uM] | 0.0 [um2/s] | cytosol |
| cAMP | 0.0 [uM] | 100.0 [um2/s] | cytosol |
| DMNB_cAMP | 0.0 [uM] | 100.0 [um2/s] | cytosol |
| light_spot | 0.0 [uM] | 0.0 [um2/s] | cytosol |
| R2C | 0.0 [uM] | D_r2c [um2/s] | cytosol |
| cAMP4_R2C2 | 0.0 [uM] | D_r2c2 [um2/s] | cytosol |
| cAMP4_R2C | 0.0 [uM] | D_r2c [um2/s] | cytosol |
| cAMP3_R2C2 | 0.0 [uM] | D_r2c2 [um2/s] | cytosol |
| cAMP_R2C2 | 0.0 [uM] | D_r2c2 [um2/s] | cytosol |
| cAMP2_R2C2 | 0.0 [uM] | D_r2c2 [um2/s] | cytosol |
| D34cyto_PP2Bcyto | 0.0 [uM] | D_d32pp2b [um2/s] | cytosol |
| PKAcyto | 0.0 [uM] | D_pkac [um2/s] | cytosol |
| D3497cyto_PP2Apcyto | 0.0 [uM] | D_d32pp2a [um2/s] | cytosol |
| Dcyto_PKAcyto | 0.0 [uM] | D_d32pkac [um2/s] | cytosol |
| PP2Acyto_PKAcyto | 0.0 [uM] | D_pp2apka [um2/s] | cytosol |
| PP2Acyto | 2.0 [uM] | D_pp2a [um2/s] | cytosol |
| cAMP4_R2 | 0.0 [uM] | D_r2 [um2/s] | cytosol |
| PP2Apcyto | 0.0 [uM] | D_pp2a [um2/s] | cytosol |
| D97cyto | 50.0 [uM] | D_d32 [um2/s] | cytosol |
| PP1cyto_D3497cyto | 0.0 [uM] | D_d32pp1 [um2/s] | cytosol |
| D34cyto | 0.0 [uM] | D_d32 [um2/s] | cytosol |
| R2C2 | 1.0 [uM] | D_r2c2 [um2/s] | cytosol |
| D3497cyto_PP2Bcyto | 0.0 [uM] | D_d32pp2b [um2/s] | cytosol |
| PP2Anuc | 2.0 [uM] | D_pp2a [um2/s] | nucleus |
| Dnuc_PKAnuc | 0.0 [uM] | D_d32pkac [um2/s] | nucleus |
| D97nuc_PP2Apnuc | 0.0 [uM] | D_d32pp2a [um2/s] | nucleus |
| PP1nuc_D34nuc_PP2Bnuc | 0.0 [uM] | D_d32pp1pp2b [um2/s] | nucleus |
| D34nuc_CK2 | 0.0 [uM] | D_d32ck2 [um2/s] | nucleus |
| Dnuc_CK2 | 0.0 [uM] | D_d32ck2 [um2/s] | nucleus |
| PP2Anuc_PKAnuc | 0.0 [uM] | D_pp2apka [um2/s] | nucleus |
| Dnuc | 0.0 [uM] | D_d32 [um2/s] | nucleus |
| D34nuc_PP2Bnuc | 0.0 [uM] | D_d32pp2b [um2/s] | nucleus |
| PP1nuc | 5.0 [uM] | D_pp1 [um2/s] | nucleus |
| PP1nuc_D34nuc | 0.0 [uM] | D_d32pp1 [um2/s] | nucleus |
| PP1nuc_D3497nuc | 0.0 [uM] | D_d32pp1 [um2/s] | nucleus |
| PP1nuc_D3497nuc_PP2Bnuc | 0.0 [uM] | D_d32pp1pp2b [um2/s] | nucleus |
| D3497nuc_PP2Apnuc | 0.0 [uM] | D_d32pp2a [um2/s] | nucleus |
| D97nuc | 30.0 [uM] | D_d32 [um2/s] | nucleus |
| D3497nuc_PP2Bnuc | 0.0 [uM] | D_d32pp2b [um2/s] | nucleus |
| CK2 | 1.0 [uM] | D_ck2 [um2/s] | nucleus |
| PP2Apnuc | 0.0 [uM] | D_pp2a [um2/s] | nucleus |
| PP2Bnuc | 1.6 [uM] | D_pp2b [um2/s] | nucleus |
| D34nuc | 0.0 [uM] | D_d32 [um2/s] | nucleus |
| D3497nuc | 0.0 [uM] | D_d32 [um2/s] | nucleus |
| PKAnuc | 0.0 [uM] | D_pkac [um2/s] | nucleus |
| D97nuc_PKAnuc | 0.0 [uM] | D_d32pkac [um2/s] | nucleus |
Specifications (Reaction) - cAMPinput_primary1 go to Simulations
| Name | Enabled? |
|---|---|
| PP1nuc_D34nuc_off | included |
| D3497cyto_PP2Bcyto_off | included |
| PP1nuc_D3497nuc_off | included |
| PP1cyto_D34cyto_PP2Bcyto_cyto2nuc | included |
| PP2Apcyto2nuc | included |
| D97cyto_PKAcyto_off | included |
| PP1cyto_D3497cyto_PP2Bcyto_cyto2nuc | included |
| D97cyto_PP2Apcyto_off | included |
| D97nuc2cyto | included |
| D3497cyto_PP2Apcyto_on | included |
| Dcyto2nuc_passive | included |
| D34cyto2nuc_passive | included |
| D3497cyto_PP2Bcyto_on | included |
| PP1nuc_D34nuc_nuc2cyto | included |
| Dnuc_CK2_cat | included |
| D3497nuc2cyto | included |
| D97nuc_PKAnuc_cat | included |
| PP2Anuc_PKAnuc_cat | included |
| D97nuc_PP2Apnuc_cat | included |
| PP1nuc_D3497nuc_PP2Bnuc_cat | included |
| PP1nuc_D3497nuc_PP2Bnuc_off | included |
| PP1cyto_D34cyto_PP2Bcyto_cat | included |
| D3497cyto2nuc | included |
| D3497nuc2cyto_passive | included |
| D3497nuc_PP2Bnuc_on | included |
| PP2Anuc2cyto | included |
| PP2Acyto_PKAcyto_cat | included |
| PP2Acyto_PKAcyto_off | included |
| D34nuc_CK2_cat | included |
| Dnuc2cyto_passive | included |
| Dnuc_CK2_off | included |
| photoUncaging_DMNB_cAMP | included |
| Dcyto_PKAcyto_on | included |
| Dnuc_PKAnuc_cat | included |
| D97nuc_PKAnuc_on | included |
| D3497cyto_PP2Bcyto_cyto2nuc | included |
| PP1cyto_D34cyto_PP2Bcyto_on | included |
| D34nuc_PP2Bnuc_on | included |
| R2_PKAcyto_bind | included |
| Dcyto_PKAcyto_off | included |
| D3497cyto_PP2Apcyto_cat | included |
| PP2Anuc_PKAnuc_on | included |
| PP2Bnuc2cyto | included |
| PP2Acyto_PKAcyto_on | included |
| PP1nuc_D3497nuc_PP2Bnuc_on | included |
| R2C_PKAcyto_bind | included |
| PP1cyto_D3497_off | included |
| D3497cyto_PP2Bcyto_cat | included |
| PP1nuc_D34nuc_PP2Bnuc_cat | included |
| PP1nuc_D34nuc_on | included |
| Dcyto_PKAcyto_cat | included |
| PP1cyto_D34cyto_PP2Bcyto_off | included |
| D97cyto_PP2Apcyto_cyto2nuc | included |
| Dnuc_CK2_on | included |
| PP1cyto_D34cyto_cyto2nuc | included |
| D3497nuc_PP2Bnuc_nuc2cyto | included |
| D3497nuc_PP2Apnuc_cat | included |
| D34nuc_PP2Bnuc_cat | included |
| Dcyto2nuc | included |
| cAMPsource2cAMP | included |
| D97nuc_PKAnuc_nuc2cyto | included |
| cAMP_PDE10A_cat | included |
| PP1cyto_D34cyto_off | included |
| PKAnuc2cyto | included |
| D3497nuc_PP2Apnuc_on | included |
| Dnuc_PKAnuc_on | included |
| D34cyto_PP2Bcyto_off | included |
| D3497cyto_PP2Apcyto_off | included |
| PP1cyto2nuc | included |
| D34nuc_CK2_off | included |
| PP1nuc_D34nuc_PP2Bnuc_off | included |
| PP1nuc_D3497nuc_PP2Bnuc_nuc2cyto | included |
| D97cyto_PP2Apcyto_on | included |
| cAMP4_R2_releasecAMP | included |
| PP2Anuc_PKAnuc_nuc2cyto | included |
| D34nuc_PP2Bnuc_off | included |
| D97cyto_PP2Apcyto_cat | included |
| PP1cyto_D3497cyto_PP2Bcyto_cat | included |
| cAMP_R2C2_onoff | included |
| D3497nuc_PP2Bnuc_cat | included |
| D34nuc_CK2_on | included |
| D97nuc_PP2Apnuc_off | included |
| D34cyto_PP2Bcyto_cyto2nuc | included |
| cAMP4_R2C_PKA_onoff | included |
| cAMP_cAMP2_R2C2_onoff | included |
| cAMP4_R2_PKA_onoff | included |
| D97nuc2cyto_passive | included |
| Dcyto_PKAcyto_cyto2nuc | included |
| PP2Apnuc2cyto | included |
| PP2Anuc_PKANuc_off | included |
| PKAcyto2nuc | included |
| PP2Acyto_PKAcyto_cyto2nuc | included |
| PP1cyto_D3497cyto_on | included |
| D97nuc_PP2Apnuc_nuc2cyto | included |
| PP2Apcytodephosphorylation | included |
| PP2Bcyto2nuc | included |
| PP1cyto_D3497cyto_PP2Bcyto_on | included |
| PP1nuc_D34nuc_PP2Bnuc_on | included |
| D97nuc_PP2Apnuc_on | included |
| D34cyto2nuc | included |
| PP2Acyto2nuc | included |
| PP1cyto_D3497cyto_PP2Bcyto_off | included |
| PP1nuc2cyto | included |
| D97cyto2nuc_passive | included |
| cAMP_cAMP_R2C2_onoff | included |
| PP1cyto_D3497cyto_cyto2nuc | included |
| PP1nuc_D3497nuc_nuc2cyto | included |
| D34cyto_PP2Bcyto_cat | included |
| D34cyto_PP2Bcyto_on | included |
| D3497nuc_PP2Bnuc_off | included |
| D3497cyto2nuc_passive | included |
| D34nuc2cyto_passive | included |
| D97cyto_PKAcyto_cyto2nuc | included |
| D3497nuc_PP2Apnuc_off | included |
| PP2Apnucdephosphorylation | included |
| PP1nuc_D3497nuc_on | included |
| D97cyto_PKAcyto_on | included |
| PP1cyto_D34cyto_on | included |
| D97cyto2nuc | included |
| Dnuc_PKAnuc_off | included |
| cAMP_cAMP3_R2C2_onoff | included |
| D3497cyto_PP2Apcyto_cyto2nuc | included |
| D3497nuc_PP2Apnuc_nuc2cyto | included |
| D97cyto_PKAcyto_cat | included |
| D97nuc_PKAnuc_off | included |
| cAMP_PDE10A_onoff | included |
Simulations - cAMPinput_primary1 go to Specifications
| Name | End Time | Output Options |
|---|---|---|
| cAMPprimaryBegin | 3600.0 |
OutputTimeStep 5.0 |
cAMPinput_primary1 Universal ID's
cAMPinput_primary1 Text Annotations
Assignments
| Name | Variable | Assignment Function Expression |
|---|
Events
| Name | Trigger Type | Variable Assignment |
|---|
Geometry Geometry1760091997
(Origin: 0.0, -14.0, 0.0; Extent: 155.0, 40.0, 11.0 [um])
| Dimension | Type | Subdomain | Adjacent Subvolumes | Size | Mapped Compartment |
|---|---|---|---|---|---|
| Volume | Analytical | subdomain2 | 301.60068965661543 [um3] | nucleus | |
| Volume | Analytical | subdomain1 | 1202.1930494498022 [um3] | cytosol | |
| Volume | Analytical | subdomain0 | 66696.20626089358 [um3] | c0 | |
| Surface | subdomain0_subdomain1_membrane | subdomain0 | subdomain1 | 1432.4688299433924 [um2] | cellmembrane | |
| Surface | subdomain1_subdomain2_membrane | subdomain1 | subdomain2 | 211.84616618489457 [um2] | nucleusmembrane |
Events
| Name | Variable | Rate Expression |
|---|
Specifications (Species) - cAMPinput_primary2 go to Simulations
| Species | Initial Condition | Diffusion Constant | Structure |
|---|---|---|---|
| cAMPsource | (200.0 * ((x >= 32.5) && (x <= 34.3) && (y >= 4.5) && (y <= 5.5) && (z >= 5.0) && (z <= 5.5)) * (t < 5.0)) [uM] | 0.0 [um2/s] | cytosol |
| D3497cyto | 0.0 [uM] | D_d32 [um2/s] | cytosol |
| PP1cyto | 5.0 [uM] | D_pp1 [um2/s] | cytosol |
| PP1cyto_D34cyto | 0.0 [uM] | D_d32pp1 [um2/s] | cytosol |
| Dcyto | 0.0 [uM] | D_d32 [um2/s] | cytosol |
| D97cyto_PP2Apcyto | 0.0 [uM] | D_d32pp2a [um2/s] | cytosol |
| R2 | 0.0 [uM] | D_r2 [um2/s] | cytosol |
| PP2Bcyto | 1.6 [uM] | D_pp2b [um2/s] | cytosol |
| PP1cyto_D3497cyto_PP2Bcyto | 0.0 [uM] | D_d32pp1pp2b [um2/s] | cytosol |
| PDE10A | 1.0 [uM] | D_pde10a [um2/s] | cytosol |
| cAMP_PDE10A | 0.0 [uM] | D_pde10a [um2/s] | cytosol |
| D97cyto_PKAcyto | 0.0 [uM] | D_d32pkac [um2/s] | cytosol |
| PP1cyto_D34cyto_PP2Bcyto | 0.0 [uM] | D_d32pp1pp2b [um2/s] | cytosol |
| AMP | 0.0 [uM] | 0.0 [um2/s] | cytosol |
| cAMP | 0.0 [uM] | 100.0 [um2/s] | cytosol |
| DMNB_cAMP | 0.0 [uM] | 100.0 [um2/s] | cytosol |
| light_spot | 0.0 [uM] | 0.0 [um2/s] | cytosol |
| R2C | 0.0 [uM] | D_r2c [um2/s] | cytosol |
| cAMP4_R2C2 | 0.0 [uM] | D_r2c2 [um2/s] | cytosol |
| cAMP4_R2C | 0.0 [uM] | D_r2c [um2/s] | cytosol |
| cAMP3_R2C2 | 0.0 [uM] | D_r2c2 [um2/s] | cytosol |
| cAMP_R2C2 | 0.0 [uM] | D_r2c2 [um2/s] | cytosol |
| cAMP2_R2C2 | 0.0 [uM] | D_r2c2 [um2/s] | cytosol |
| D34cyto_PP2Bcyto | 0.0 [uM] | D_d32pp2b [um2/s] | cytosol |
| PKAcyto | 0.0 [uM] | D_pkac [um2/s] | cytosol |
| D3497cyto_PP2Apcyto | 0.0 [uM] | D_d32pp2a [um2/s] | cytosol |
| Dcyto_PKAcyto | 0.0 [uM] | D_d32pkac [um2/s] | cytosol |
| PP2Acyto_PKAcyto | 0.0 [uM] | D_pp2apka [um2/s] | cytosol |
| PP2Acyto | 2.0 [uM] | D_pp2a [um2/s] | cytosol |
| cAMP4_R2 | 0.0 [uM] | D_r2 [um2/s] | cytosol |
| PP2Apcyto | 0.0 [uM] | D_pp2a [um2/s] | cytosol |
| D97cyto | 50.0 [uM] | D_d32 [um2/s] | cytosol |
| PP1cyto_D3497cyto | 0.0 [uM] | D_d32pp1 [um2/s] | cytosol |
| D34cyto | 0.0 [uM] | D_d32 [um2/s] | cytosol |
| R2C2 | 1.0 [uM] | D_r2c2 [um2/s] | cytosol |
| D3497cyto_PP2Bcyto | 0.0 [uM] | D_d32pp2b [um2/s] | cytosol |
| PP2Anuc | 2.0 [uM] | D_pp2a [um2/s] | nucleus |
| Dnuc_PKAnuc | 0.0 [uM] | D_d32pkac [um2/s] | nucleus |
| D97nuc_PP2Apnuc | 0.0 [uM] | D_d32pp2a [um2/s] | nucleus |
| PP1nuc_D34nuc_PP2Bnuc | 0.0 [uM] | D_d32pp1pp2b [um2/s] | nucleus |
| D34nuc_CK2 | 0.0 [uM] | D_d32ck2 [um2/s] | nucleus |
| Dnuc_CK2 | 0.0 [uM] | D_d32ck2 [um2/s] | nucleus |
| PP2Anuc_PKAnuc | 0.0 [uM] | D_pp2apka [um2/s] | nucleus |
| Dnuc | 0.0 [uM] | D_d32 [um2/s] | nucleus |
| D34nuc_PP2Bnuc | 0.0 [uM] | D_d32pp2b [um2/s] | nucleus |
| PP1nuc | 5.0 [uM] | D_pp1 [um2/s] | nucleus |
| PP1nuc_D34nuc | 0.0 [uM] | D_d32pp1 [um2/s] | nucleus |
| PP1nuc_D3497nuc | 0.0 [uM] | D_d32pp1 [um2/s] | nucleus |
| PP1nuc_D3497nuc_PP2Bnuc | 0.0 [uM] | D_d32pp1pp2b [um2/s] | nucleus |
| D3497nuc_PP2Apnuc | 0.0 [uM] | D_d32pp2a [um2/s] | nucleus |
| D97nuc | 30.0 [uM] | D_d32 [um2/s] | nucleus |
| D3497nuc_PP2Bnuc | 0.0 [uM] | D_d32pp2b [um2/s] | nucleus |
| CK2 | 1.0 [uM] | D_ck2 [um2/s] | nucleus |
| PP2Apnuc | 0.0 [uM] | D_pp2a [um2/s] | nucleus |
| PP2Bnuc | 1.6 [uM] | D_pp2b [um2/s] | nucleus |
| D34nuc | 0.0 [uM] | D_d32 [um2/s] | nucleus |
| D3497nuc | 0.0 [uM] | D_d32 [um2/s] | nucleus |
| PKAnuc | 0.0 [uM] | D_pkac [um2/s] | nucleus |
| D97nuc_PKAnuc | 0.0 [uM] | D_d32pkac [um2/s] | nucleus |
Specifications (Reaction) - cAMPinput_primary2 go to Simulations
| Name | Enabled? |
|---|---|
| PP1nuc_D34nuc_off | included |
| D3497cyto_PP2Bcyto_off | included |
| PP1nuc_D3497nuc_off | included |
| PP1cyto_D34cyto_PP2Bcyto_cyto2nuc | included |
| PP2Apcyto2nuc | included |
| D97cyto_PKAcyto_off | included |
| PP1cyto_D3497cyto_PP2Bcyto_cyto2nuc | included |
| D97cyto_PP2Apcyto_off | included |
| D97nuc2cyto | included |
| D3497cyto_PP2Apcyto_on | included |
| Dcyto2nuc_passive | included |
| D34cyto2nuc_passive | included |
| D3497cyto_PP2Bcyto_on | included |
| PP1nuc_D34nuc_nuc2cyto | included |
| Dnuc_CK2_cat | included |
| D3497nuc2cyto | included |
| D97nuc_PKAnuc_cat | included |
| PP2Anuc_PKAnuc_cat | included |
| D97nuc_PP2Apnuc_cat | included |
| PP1nuc_D3497nuc_PP2Bnuc_cat | included |
| PP1nuc_D3497nuc_PP2Bnuc_off | included |
| PP1cyto_D34cyto_PP2Bcyto_cat | included |
| D3497cyto2nuc | included |
| D3497nuc2cyto_passive | included |
| D3497nuc_PP2Bnuc_on | included |
| PP2Anuc2cyto | included |
| PP2Acyto_PKAcyto_cat | included |
| PP2Acyto_PKAcyto_off | included |
| D34nuc_CK2_cat | included |
| Dnuc2cyto_passive | included |
| Dnuc_CK2_off | included |
| photoUncaging_DMNB_cAMP | included |
| Dcyto_PKAcyto_on | included |
| Dnuc_PKAnuc_cat | included |
| D97nuc_PKAnuc_on | included |
| D3497cyto_PP2Bcyto_cyto2nuc | included |
| PP1cyto_D34cyto_PP2Bcyto_on | included |
| D34nuc_PP2Bnuc_on | included |
| R2_PKAcyto_bind | included |
| Dcyto_PKAcyto_off | included |
| D3497cyto_PP2Apcyto_cat | included |
| PP2Anuc_PKAnuc_on | included |
| PP2Bnuc2cyto | included |
| PP2Acyto_PKAcyto_on | included |
| PP1nuc_D3497nuc_PP2Bnuc_on | included |
| R2C_PKAcyto_bind | included |
| PP1cyto_D3497_off | included |
| D3497cyto_PP2Bcyto_cat | included |
| PP1nuc_D34nuc_PP2Bnuc_cat | included |
| PP1nuc_D34nuc_on | included |
| Dcyto_PKAcyto_cat | included |
| PP1cyto_D34cyto_PP2Bcyto_off | included |
| D97cyto_PP2Apcyto_cyto2nuc | included |
| Dnuc_CK2_on | included |
| PP1cyto_D34cyto_cyto2nuc | included |
| D3497nuc_PP2Bnuc_nuc2cyto | included |
| D3497nuc_PP2Apnuc_cat | included |
| D34nuc_PP2Bnuc_cat | included |
| Dcyto2nuc | included |
| cAMPsource2cAMP | included |
| D97nuc_PKAnuc_nuc2cyto | included |
| cAMP_PDE10A_cat | included |
| PP1cyto_D34cyto_off | included |
| PKAnuc2cyto | included |
| D3497nuc_PP2Apnuc_on | included |
| Dnuc_PKAnuc_on | included |
| D34cyto_PP2Bcyto_off | included |
| D3497cyto_PP2Apcyto_off | included |
| PP1cyto2nuc | included |
| D34nuc_CK2_off | included |
| PP1nuc_D34nuc_PP2Bnuc_off | included |
| PP1nuc_D3497nuc_PP2Bnuc_nuc2cyto | included |
| D97cyto_PP2Apcyto_on | included |
| cAMP4_R2_releasecAMP | included |
| PP2Anuc_PKAnuc_nuc2cyto | included |
| D34nuc_PP2Bnuc_off | included |
| D97cyto_PP2Apcyto_cat | included |
| PP1cyto_D3497cyto_PP2Bcyto_cat | included |
| cAMP_R2C2_onoff | included |
| D3497nuc_PP2Bnuc_cat | included |
| D34nuc_CK2_on | included |
| D97nuc_PP2Apnuc_off | included |
| D34cyto_PP2Bcyto_cyto2nuc | included |
| cAMP4_R2C_PKA_onoff | included |
| cAMP_cAMP2_R2C2_onoff | included |
| cAMP4_R2_PKA_onoff | included |
| D97nuc2cyto_passive | included |
| Dcyto_PKAcyto_cyto2nuc | included |
| PP2Apnuc2cyto | included |
| PP2Anuc_PKANuc_off | included |
| PKAcyto2nuc | included |
| PP2Acyto_PKAcyto_cyto2nuc | included |
| PP1cyto_D3497cyto_on | included |
| D97nuc_PP2Apnuc_nuc2cyto | included |
| PP2Apcytodephosphorylation | included |
| PP2Bcyto2nuc | included |
| PP1cyto_D3497cyto_PP2Bcyto_on | included |
| PP1nuc_D34nuc_PP2Bnuc_on | included |
| D97nuc_PP2Apnuc_on | included |
| D34cyto2nuc | included |
| PP2Acyto2nuc | included |
| PP1cyto_D3497cyto_PP2Bcyto_off | included |
| PP1nuc2cyto | included |
| D97cyto2nuc_passive | included |
| cAMP_cAMP_R2C2_onoff | included |
| PP1cyto_D3497cyto_cyto2nuc | included |
| PP1nuc_D3497nuc_nuc2cyto | included |
| D34cyto_PP2Bcyto_cat | included |
| D34cyto_PP2Bcyto_on | included |
| D3497nuc_PP2Bnuc_off | included |
| D3497cyto2nuc_passive | included |
| D34nuc2cyto_passive | included |
| D97cyto_PKAcyto_cyto2nuc | included |
| D3497nuc_PP2Apnuc_off | included |
| PP2Apnucdephosphorylation | included |
| PP1nuc_D3497nuc_on | included |
| D97cyto_PKAcyto_on | included |
| PP1cyto_D34cyto_on | included |
| D97cyto2nuc | included |
| Dnuc_PKAnuc_off | included |
| cAMP_cAMP3_R2C2_onoff | included |
| D3497cyto_PP2Apcyto_cyto2nuc | included |
| D3497nuc_PP2Apnuc_nuc2cyto | included |
| D97cyto_PKAcyto_cat | included |
| D97nuc_PKAnuc_off | included |
| cAMP_PDE10A_onoff | included |
Simulations - cAMPinput_primary2 go to Specifications
| Name | End Time | Output Options |
|---|---|---|
| primaryMiddle | 3600.0 |
OutputTimeStep 5.0 |
cAMPinput_primary2 Universal ID's
cAMPinput_primary2 Text Annotations
Assignments
| Name | Variable | Assignment Function Expression |
|---|
Events
| Name | Trigger Type | Variable Assignment |
|---|
Geometry Geometry1760091997
(Origin: 0.0, -14.0, 0.0; Extent: 155.0, 40.0, 11.0 [um])
| Dimension | Type | Subdomain | Adjacent Subvolumes | Size | Mapped Compartment |
|---|---|---|---|---|---|
| Volume | Analytical | subdomain2 | 301.60068965661543 [um3] | nucleus | |
| Volume | Analytical | subdomain1 | 1202.1930494498022 [um3] | cytosol | |
| Volume | Analytical | subdomain0 | 66696.20626089358 [um3] | c0 | |
| Surface | subdomain0_subdomain1_membrane | subdomain0 | subdomain1 | 1432.4688299433924 [um2] | cellmembrane | |
| Surface | subdomain1_subdomain2_membrane | subdomain1 | subdomain2 | 211.84616618489457 [um2] | nucleusmembrane |
Events
| Name | Variable | Rate Expression |
|---|
Specifications (Species) - cAMPinput_secondary1 go to Simulations
| Species | Initial Condition | Diffusion Constant | Structure |
|---|---|---|---|
| cAMPsource | (200.0 * ((x >= 61.0) && (x <= 62.8) && (y >= - 1.5) && (y <= 0.0) && (z >= 5.0) && (z <= 5.5)) * (t < 5.0)) [uM] | 0.0 [um2/s] | cytosol |
| D3497cyto | 0.0 [uM] | D_d32 [um2/s] | cytosol |
| PP1cyto | 5.0 [uM] | D_pp1 [um2/s] | cytosol |
| PP1cyto_D34cyto | 0.0 [uM] | D_d32pp1 [um2/s] | cytosol |
| Dcyto | 0.0 [uM] | D_d32 [um2/s] | cytosol |
| D97cyto_PP2Apcyto | 0.0 [uM] | D_d32pp2a [um2/s] | cytosol |
| R2 | 0.0 [uM] | D_r2 [um2/s] | cytosol |
| PP2Bcyto | 1.6 [uM] | D_pp2b [um2/s] | cytosol |
| PP1cyto_D3497cyto_PP2Bcyto | 0.0 [uM] | D_d32pp1pp2b [um2/s] | cytosol |
| PDE10A | 1.0 [uM] | D_pde10a [um2/s] | cytosol |
| cAMP_PDE10A | 0.0 [uM] | D_pde10a [um2/s] | cytosol |
| D97cyto_PKAcyto | 0.0 [uM] | D_d32pkac [um2/s] | cytosol |
| PP1cyto_D34cyto_PP2Bcyto | 0.0 [uM] | D_d32pp1pp2b [um2/s] | cytosol |
| AMP | 0.0 [uM] | 0.0 [um2/s] | cytosol |
| cAMP | 0.0 [uM] | 100.0 [um2/s] | cytosol |
| DMNB_cAMP | 0.0 [uM] | 100.0 [um2/s] | cytosol |
| light_spot | 0.0 [uM] | 0.0 [um2/s] | cytosol |
| R2C | 0.0 [uM] | D_r2c [um2/s] | cytosol |
| cAMP4_R2C2 | 0.0 [uM] | D_r2c2 [um2/s] | cytosol |
| cAMP4_R2C | 0.0 [uM] | D_r2c [um2/s] | cytosol |
| cAMP3_R2C2 | 0.0 [uM] | D_r2c2 [um2/s] | cytosol |
| cAMP_R2C2 | 0.0 [uM] | D_r2c2 [um2/s] | cytosol |
| cAMP2_R2C2 | 0.0 [uM] | D_r2c2 [um2/s] | cytosol |
| D34cyto_PP2Bcyto | 0.0 [uM] | D_d32pp2b [um2/s] | cytosol |
| PKAcyto | 0.0 [uM] | D_pkac [um2/s] | cytosol |
| D3497cyto_PP2Apcyto | 0.0 [uM] | D_d32pp2a [um2/s] | cytosol |
| Dcyto_PKAcyto | 0.0 [uM] | D_d32pkac [um2/s] | cytosol |
| PP2Acyto_PKAcyto | 0.0 [uM] | D_pp2apka [um2/s] | cytosol |
| PP2Acyto | 2.0 [uM] | D_pp2a [um2/s] | cytosol |
| cAMP4_R2 | 0.0 [uM] | D_r2 [um2/s] | cytosol |
| PP2Apcyto | 0.0 [uM] | D_pp2a [um2/s] | cytosol |
| D97cyto | 50.0 [uM] | D_d32 [um2/s] | cytosol |
| PP1cyto_D3497cyto | 0.0 [uM] | D_d32pp1 [um2/s] | cytosol |
| D34cyto | 0.0 [uM] | D_d32 [um2/s] | cytosol |
| R2C2 | 1.0 [uM] | D_r2c2 [um2/s] | cytosol |
| D3497cyto_PP2Bcyto | 0.0 [uM] | D_d32pp2b [um2/s] | cytosol |
| PP2Anuc | 2.0 [uM] | D_pp2a [um2/s] | nucleus |
| Dnuc_PKAnuc | 0.0 [uM] | D_d32pkac [um2/s] | nucleus |
| D97nuc_PP2Apnuc | 0.0 [uM] | D_d32pp2a [um2/s] | nucleus |
| PP1nuc_D34nuc_PP2Bnuc | 0.0 [uM] | D_d32pp1pp2b [um2/s] | nucleus |
| D34nuc_CK2 | 0.0 [uM] | D_d32ck2 [um2/s] | nucleus |
| Dnuc_CK2 | 0.0 [uM] | D_d32ck2 [um2/s] | nucleus |
| PP2Anuc_PKAnuc | 0.0 [uM] | D_pp2apka [um2/s] | nucleus |
| Dnuc | 0.0 [uM] | D_d32 [um2/s] | nucleus |
| D34nuc_PP2Bnuc | 0.0 [uM] | D_d32pp2b [um2/s] | nucleus |
| PP1nuc | 5.0 [uM] | D_pp1 [um2/s] | nucleus |
| PP1nuc_D34nuc | 0.0 [uM] | D_d32pp1 [um2/s] | nucleus |
| PP1nuc_D3497nuc | 0.0 [uM] | D_d32pp1 [um2/s] | nucleus |
| PP1nuc_D3497nuc_PP2Bnuc | 0.0 [uM] | D_d32pp1pp2b [um2/s] | nucleus |
| D3497nuc_PP2Apnuc | 0.0 [uM] | D_d32pp2a [um2/s] | nucleus |
| D97nuc | 30.0 [uM] | D_d32 [um2/s] | nucleus |
| D3497nuc_PP2Bnuc | 0.0 [uM] | D_d32pp2b [um2/s] | nucleus |
| CK2 | 1.0 [uM] | D_ck2 [um2/s] | nucleus |
| PP2Apnuc | 0.0 [uM] | D_pp2a [um2/s] | nucleus |
| PP2Bnuc | 1.6 [uM] | D_pp2b [um2/s] | nucleus |
| D34nuc | 0.0 [uM] | D_d32 [um2/s] | nucleus |
| D3497nuc | 0.0 [uM] | D_d32 [um2/s] | nucleus |
| PKAnuc | 0.0 [uM] | D_pkac [um2/s] | nucleus |
| D97nuc_PKAnuc | 0.0 [uM] | D_d32pkac [um2/s] | nucleus |
Specifications (Reaction) - cAMPinput_secondary1 go to Simulations
| Name | Enabled? |
|---|---|
| PP1nuc_D34nuc_off | included |
| D3497cyto_PP2Bcyto_off | included |
| PP1nuc_D3497nuc_off | included |
| PP1cyto_D34cyto_PP2Bcyto_cyto2nuc | included |
| PP2Apcyto2nuc | included |
| D97cyto_PKAcyto_off | included |
| PP1cyto_D3497cyto_PP2Bcyto_cyto2nuc | included |
| D97cyto_PP2Apcyto_off | included |
| D97nuc2cyto | included |
| D3497cyto_PP2Apcyto_on | included |
| Dcyto2nuc_passive | included |
| D34cyto2nuc_passive | included |
| D3497cyto_PP2Bcyto_on | included |
| PP1nuc_D34nuc_nuc2cyto | included |
| Dnuc_CK2_cat | included |
| D3497nuc2cyto | included |
| D97nuc_PKAnuc_cat | included |
| PP2Anuc_PKAnuc_cat | included |
| D97nuc_PP2Apnuc_cat | included |
| PP1nuc_D3497nuc_PP2Bnuc_cat | included |
| PP1nuc_D3497nuc_PP2Bnuc_off | included |
| PP1cyto_D34cyto_PP2Bcyto_cat | included |
| D3497cyto2nuc | included |
| D3497nuc2cyto_passive | included |
| D3497nuc_PP2Bnuc_on | included |
| PP2Anuc2cyto | included |
| PP2Acyto_PKAcyto_cat | included |
| PP2Acyto_PKAcyto_off | included |
| D34nuc_CK2_cat | included |
| Dnuc2cyto_passive | included |
| Dnuc_CK2_off | included |
| photoUncaging_DMNB_cAMP | included |
| Dcyto_PKAcyto_on | included |
| Dnuc_PKAnuc_cat | included |
| D97nuc_PKAnuc_on | included |
| D3497cyto_PP2Bcyto_cyto2nuc | included |
| PP1cyto_D34cyto_PP2Bcyto_on | included |
| D34nuc_PP2Bnuc_on | included |
| R2_PKAcyto_bind | included |
| Dcyto_PKAcyto_off | included |
| D3497cyto_PP2Apcyto_cat | included |
| PP2Anuc_PKAnuc_on | included |
| PP2Bnuc2cyto | included |
| PP2Acyto_PKAcyto_on | included |
| PP1nuc_D3497nuc_PP2Bnuc_on | included |
| R2C_PKAcyto_bind | included |
| PP1cyto_D3497_off | included |
| D3497cyto_PP2Bcyto_cat | included |
| PP1nuc_D34nuc_PP2Bnuc_cat | included |
| PP1nuc_D34nuc_on | included |
| Dcyto_PKAcyto_cat | included |
| PP1cyto_D34cyto_PP2Bcyto_off | included |
| D97cyto_PP2Apcyto_cyto2nuc | included |
| Dnuc_CK2_on | included |
| PP1cyto_D34cyto_cyto2nuc | included |
| D3497nuc_PP2Bnuc_nuc2cyto | included |
| D3497nuc_PP2Apnuc_cat | included |
| D34nuc_PP2Bnuc_cat | included |
| Dcyto2nuc | included |
| cAMPsource2cAMP | included |
| D97nuc_PKAnuc_nuc2cyto | included |
| cAMP_PDE10A_cat | included |
| PP1cyto_D34cyto_off | included |
| PKAnuc2cyto | included |
| D3497nuc_PP2Apnuc_on | included |
| Dnuc_PKAnuc_on | included |
| D34cyto_PP2Bcyto_off | included |
| D3497cyto_PP2Apcyto_off | included |
| PP1cyto2nuc | included |
| D34nuc_CK2_off | included |
| PP1nuc_D34nuc_PP2Bnuc_off | included |
| PP1nuc_D3497nuc_PP2Bnuc_nuc2cyto | included |
| D97cyto_PP2Apcyto_on | included |
| cAMP4_R2_releasecAMP | included |
| PP2Anuc_PKAnuc_nuc2cyto | included |
| D34nuc_PP2Bnuc_off | included |
| D97cyto_PP2Apcyto_cat | included |
| PP1cyto_D3497cyto_PP2Bcyto_cat | included |
| cAMP_R2C2_onoff | included |
| D3497nuc_PP2Bnuc_cat | included |
| D34nuc_CK2_on | included |
| D97nuc_PP2Apnuc_off | included |
| D34cyto_PP2Bcyto_cyto2nuc | included |
| cAMP4_R2C_PKA_onoff | included |
| cAMP_cAMP2_R2C2_onoff | included |
| cAMP4_R2_PKA_onoff | included |
| D97nuc2cyto_passive | included |
| Dcyto_PKAcyto_cyto2nuc | included |
| PP2Apnuc2cyto | included |
| PP2Anuc_PKANuc_off | included |
| PKAcyto2nuc | included |
| PP2Acyto_PKAcyto_cyto2nuc | included |
| PP1cyto_D3497cyto_on | included |
| D97nuc_PP2Apnuc_nuc2cyto | included |
| PP2Apcytodephosphorylation | included |
| PP2Bcyto2nuc | included |
| PP1cyto_D3497cyto_PP2Bcyto_on | included |
| PP1nuc_D34nuc_PP2Bnuc_on | included |
| D97nuc_PP2Apnuc_on | included |
| D34cyto2nuc | included |
| PP2Acyto2nuc | included |
| PP1cyto_D3497cyto_PP2Bcyto_off | included |
| PP1nuc2cyto | included |
| D97cyto2nuc_passive | included |
| cAMP_cAMP_R2C2_onoff | included |
| PP1cyto_D3497cyto_cyto2nuc | included |
| PP1nuc_D3497nuc_nuc2cyto | included |
| D34cyto_PP2Bcyto_cat | included |
| D34cyto_PP2Bcyto_on | included |
| D3497nuc_PP2Bnuc_off | included |
| D3497cyto2nuc_passive | included |
| D34nuc2cyto_passive | included |
| D97cyto_PKAcyto_cyto2nuc | included |
| D3497nuc_PP2Apnuc_off | included |
| PP2Apnucdephosphorylation | included |
| PP1nuc_D3497nuc_on | included |
| D97cyto_PKAcyto_on | included |
| PP1cyto_D34cyto_on | included |
| D97cyto2nuc | included |
| Dnuc_PKAnuc_off | included |
| cAMP_cAMP3_R2C2_onoff | included |
| D3497cyto_PP2Apcyto_cyto2nuc | included |
| D3497nuc_PP2Apnuc_nuc2cyto | included |
| D97cyto_PKAcyto_cat | included |
| D97nuc_PKAnuc_off | included |
| cAMP_PDE10A_onoff | included |
Simulations - cAMPinput_secondary1 go to Specifications
| Name | End Time | Output Options |
|---|---|---|
| cAMPsecondaryMiddle1 | 3600.0 |
OutputTimeStep 5.0 |
cAMPinput_secondary1 Universal ID's
cAMPinput_secondary1 Text Annotations
Assignments
| Name | Variable | Assignment Function Expression |
|---|
Events
| Name | Trigger Type | Variable Assignment |
|---|
Geometry Geometry1760091997
(Origin: 0.0, -14.0, 0.0; Extent: 155.0, 40.0, 11.0 [um])
| Dimension | Type | Subdomain | Adjacent Subvolumes | Size | Mapped Compartment |
|---|---|---|---|---|---|
| Volume | Analytical | subdomain2 | 301.60068965661543 [um3] | nucleus | |
| Volume | Analytical | subdomain1 | 1202.1930494498022 [um3] | cytosol | |
| Volume | Analytical | subdomain0 | 66696.20626089358 [um3] | c0 | |
| Surface | subdomain0_subdomain1_membrane | subdomain0 | subdomain1 | 1432.4688299433924 [um2] | cellmembrane | |
| Surface | subdomain1_subdomain2_membrane | subdomain1 | subdomain2 | 211.84616618489457 [um2] | nucleusmembrane |
Events
| Name | Variable | Rate Expression |
|---|
Specifications (Species) - cAMPinput_secondary2 go to Simulations
| Species | Initial Condition | Diffusion Constant | Structure |
|---|---|---|---|
| cAMPsource | (200.0 * ((x >= 77.5) && (x <= 79.3) && (y >= - 7.5) && (y <= - 6.0) && (z >= 5.0) && (z <= 5.5)) * (t < 5.0)) [uM] | 0.0 [um2/s] | cytosol |
| D3497cyto | 0.0 [uM] | D_d32 [um2/s] | cytosol |
| PP1cyto | 5.0 [uM] | D_pp1 [um2/s] | cytosol |
| PP1cyto_D34cyto | 0.0 [uM] | D_d32pp1 [um2/s] | cytosol |
| Dcyto | 0.0 [uM] | D_d32 [um2/s] | cytosol |
| D97cyto_PP2Apcyto | 0.0 [uM] | D_d32pp2a [um2/s] | cytosol |
| R2 | 0.0 [uM] | D_r2 [um2/s] | cytosol |
| PP2Bcyto | 1.6 [uM] | D_pp2b [um2/s] | cytosol |
| PP1cyto_D3497cyto_PP2Bcyto | 0.0 [uM] | D_d32pp1pp2b [um2/s] | cytosol |
| PDE10A | 1.0 [uM] | D_pde10a [um2/s] | cytosol |
| cAMP_PDE10A | 0.0 [uM] | D_pde10a [um2/s] | cytosol |
| D97cyto_PKAcyto | 0.0 [uM] | D_d32pkac [um2/s] | cytosol |
| PP1cyto_D34cyto_PP2Bcyto | 0.0 [uM] | D_d32pp1pp2b [um2/s] | cytosol |
| AMP | 0.0 [uM] | 0.0 [um2/s] | cytosol |
| cAMP | 0.0 [uM] | 100.0 [um2/s] | cytosol |
| DMNB_cAMP | 0.0 [uM] | 100.0 [um2/s] | cytosol |
| light_spot | 0.0 [uM] | 0.0 [um2/s] | cytosol |
| R2C | 0.0 [uM] | D_r2c [um2/s] | cytosol |
| cAMP4_R2C2 | 0.0 [uM] | D_r2c2 [um2/s] | cytosol |
| cAMP4_R2C | 0.0 [uM] | D_r2c [um2/s] | cytosol |
| cAMP3_R2C2 | 0.0 [uM] | D_r2c2 [um2/s] | cytosol |
| cAMP_R2C2 | 0.0 [uM] | D_r2c2 [um2/s] | cytosol |
| cAMP2_R2C2 | 0.0 [uM] | D_r2c2 [um2/s] | cytosol |
| D34cyto_PP2Bcyto | 0.0 [uM] | D_d32pp2b [um2/s] | cytosol |
| PKAcyto | 0.0 [uM] | D_pkac [um2/s] | cytosol |
| D3497cyto_PP2Apcyto | 0.0 [uM] | D_d32pp2a [um2/s] | cytosol |
| Dcyto_PKAcyto | 0.0 [uM] | D_d32pkac [um2/s] | cytosol |
| PP2Acyto_PKAcyto | 0.0 [uM] | D_pp2apka [um2/s] | cytosol |
| PP2Acyto | 2.0 [uM] | D_pp2a [um2/s] | cytosol |
| cAMP4_R2 | 0.0 [uM] | D_r2 [um2/s] | cytosol |
| PP2Apcyto | 0.0 [uM] | D_pp2a [um2/s] | cytosol |
| D97cyto | 50.0 [uM] | D_d32 [um2/s] | cytosol |
| PP1cyto_D3497cyto | 0.0 [uM] | D_d32pp1 [um2/s] | cytosol |
| D34cyto | 0.0 [uM] | D_d32 [um2/s] | cytosol |
| R2C2 | 1.0 [uM] | D_r2c2 [um2/s] | cytosol |
| D3497cyto_PP2Bcyto | 0.0 [uM] | D_d32pp2b [um2/s] | cytosol |
| PP2Anuc | 2.0 [uM] | D_pp2a [um2/s] | nucleus |
| Dnuc_PKAnuc | 0.0 [uM] | D_d32pkac [um2/s] | nucleus |
| D97nuc_PP2Apnuc | 0.0 [uM] | D_d32pp2a [um2/s] | nucleus |
| PP1nuc_D34nuc_PP2Bnuc | 0.0 [uM] | D_d32pp1pp2b [um2/s] | nucleus |
| D34nuc_CK2 | 0.0 [uM] | D_d32ck2 [um2/s] | nucleus |
| Dnuc_CK2 | 0.0 [uM] | D_d32ck2 [um2/s] | nucleus |
| PP2Anuc_PKAnuc | 0.0 [uM] | D_pp2apka [um2/s] | nucleus |
| Dnuc | 0.0 [uM] | D_d32 [um2/s] | nucleus |
| D34nuc_PP2Bnuc | 0.0 [uM] | D_d32pp2b [um2/s] | nucleus |
| PP1nuc | 5.0 [uM] | D_pp1 [um2/s] | nucleus |
| PP1nuc_D34nuc | 0.0 [uM] | D_d32pp1 [um2/s] | nucleus |
| PP1nuc_D3497nuc | 0.0 [uM] | D_d32pp1 [um2/s] | nucleus |
| PP1nuc_D3497nuc_PP2Bnuc | 0.0 [uM] | D_d32pp1pp2b [um2/s] | nucleus |
| D3497nuc_PP2Apnuc | 0.0 [uM] | D_d32pp2a [um2/s] | nucleus |
| D97nuc | 30.0 [uM] | D_d32 [um2/s] | nucleus |
| D3497nuc_PP2Bnuc | 0.0 [uM] | D_d32pp2b [um2/s] | nucleus |
| CK2 | 1.0 [uM] | D_ck2 [um2/s] | nucleus |
| PP2Apnuc | 0.0 [uM] | D_pp2a [um2/s] | nucleus |
| PP2Bnuc | 1.6 [uM] | D_pp2b [um2/s] | nucleus |
| D34nuc | 0.0 [uM] | D_d32 [um2/s] | nucleus |
| D3497nuc | 0.0 [uM] | D_d32 [um2/s] | nucleus |
| PKAnuc | 0.0 [uM] | D_pkac [um2/s] | nucleus |
| D97nuc_PKAnuc | 0.0 [uM] | D_d32pkac [um2/s] | nucleus |
Specifications (Reaction) - cAMPinput_secondary2 go to Simulations
| Name | Enabled? |
|---|---|
| PP1nuc_D34nuc_off | included |
| D3497cyto_PP2Bcyto_off | included |
| PP1nuc_D3497nuc_off | included |
| PP1cyto_D34cyto_PP2Bcyto_cyto2nuc | included |
| PP2Apcyto2nuc | included |
| D97cyto_PKAcyto_off | included |
| PP1cyto_D3497cyto_PP2Bcyto_cyto2nuc | included |
| D97cyto_PP2Apcyto_off | included |
| D97nuc2cyto | included |
| D3497cyto_PP2Apcyto_on | included |
| Dcyto2nuc_passive | included |
| D34cyto2nuc_passive | included |
| D3497cyto_PP2Bcyto_on | included |
| PP1nuc_D34nuc_nuc2cyto | included |
| Dnuc_CK2_cat | included |
| D3497nuc2cyto | included |
| D97nuc_PKAnuc_cat | included |
| PP2Anuc_PKAnuc_cat | included |
| D97nuc_PP2Apnuc_cat | included |
| PP1nuc_D3497nuc_PP2Bnuc_cat | included |
| PP1nuc_D3497nuc_PP2Bnuc_off | included |
| PP1cyto_D34cyto_PP2Bcyto_cat | included |
| D3497cyto2nuc | included |
| D3497nuc2cyto_passive | included |
| D3497nuc_PP2Bnuc_on | included |
| PP2Anuc2cyto | included |
| PP2Acyto_PKAcyto_cat | included |
| PP2Acyto_PKAcyto_off | included |
| D34nuc_CK2_cat | included |
| Dnuc2cyto_passive | included |
| Dnuc_CK2_off | included |
| photoUncaging_DMNB_cAMP | included |
| Dcyto_PKAcyto_on | included |
| Dnuc_PKAnuc_cat | included |
| D97nuc_PKAnuc_on | included |
| D3497cyto_PP2Bcyto_cyto2nuc | included |
| PP1cyto_D34cyto_PP2Bcyto_on | included |
| D34nuc_PP2Bnuc_on | included |
| R2_PKAcyto_bind | included |
| Dcyto_PKAcyto_off | included |
| D3497cyto_PP2Apcyto_cat | included |
| PP2Anuc_PKAnuc_on | included |
| PP2Bnuc2cyto | included |
| PP2Acyto_PKAcyto_on | included |
| PP1nuc_D3497nuc_PP2Bnuc_on | included |
| R2C_PKAcyto_bind | included |
| PP1cyto_D3497_off | included |
| D3497cyto_PP2Bcyto_cat | included |
| PP1nuc_D34nuc_PP2Bnuc_cat | included |
| PP1nuc_D34nuc_on | included |
| Dcyto_PKAcyto_cat | included |
| PP1cyto_D34cyto_PP2Bcyto_off | included |
| D97cyto_PP2Apcyto_cyto2nuc | included |
| Dnuc_CK2_on | included |
| PP1cyto_D34cyto_cyto2nuc | included |
| D3497nuc_PP2Bnuc_nuc2cyto | included |
| D3497nuc_PP2Apnuc_cat | included |
| D34nuc_PP2Bnuc_cat | included |
| Dcyto2nuc | included |
| cAMPsource2cAMP | included |
| D97nuc_PKAnuc_nuc2cyto | included |
| cAMP_PDE10A_cat | included |
| PP1cyto_D34cyto_off | included |
| PKAnuc2cyto | included |
| D3497nuc_PP2Apnuc_on | included |
| Dnuc_PKAnuc_on | included |
| D34cyto_PP2Bcyto_off | included |
| D3497cyto_PP2Apcyto_off | included |
| PP1cyto2nuc | included |
| D34nuc_CK2_off | included |
| PP1nuc_D34nuc_PP2Bnuc_off | included |
| PP1nuc_D3497nuc_PP2Bnuc_nuc2cyto | included |
| D97cyto_PP2Apcyto_on | included |
| cAMP4_R2_releasecAMP | included |
| PP2Anuc_PKAnuc_nuc2cyto | included |
| D34nuc_PP2Bnuc_off | included |
| D97cyto_PP2Apcyto_cat | included |
| PP1cyto_D3497cyto_PP2Bcyto_cat | included |
| cAMP_R2C2_onoff | included |
| D3497nuc_PP2Bnuc_cat | included |
| D34nuc_CK2_on | included |
| D97nuc_PP2Apnuc_off | included |
| D34cyto_PP2Bcyto_cyto2nuc | included |
| cAMP4_R2C_PKA_onoff | included |
| cAMP_cAMP2_R2C2_onoff | included |
| cAMP4_R2_PKA_onoff | included |
| D97nuc2cyto_passive | included |
| Dcyto_PKAcyto_cyto2nuc | included |
| PP2Apnuc2cyto | included |
| PP2Anuc_PKANuc_off | included |
| PKAcyto2nuc | included |
| PP2Acyto_PKAcyto_cyto2nuc | included |
| PP1cyto_D3497cyto_on | included |
| D97nuc_PP2Apnuc_nuc2cyto | included |
| PP2Apcytodephosphorylation | included |
| PP2Bcyto2nuc | included |
| PP1cyto_D3497cyto_PP2Bcyto_on | included |
| PP1nuc_D34nuc_PP2Bnuc_on | included |
| D97nuc_PP2Apnuc_on | included |
| D34cyto2nuc | included |
| PP2Acyto2nuc | included |
| PP1cyto_D3497cyto_PP2Bcyto_off | included |
| PP1nuc2cyto | included |
| D97cyto2nuc_passive | included |
| cAMP_cAMP_R2C2_onoff | included |
| PP1cyto_D3497cyto_cyto2nuc | included |
| PP1nuc_D3497nuc_nuc2cyto | included |
| D34cyto_PP2Bcyto_cat | included |
| D34cyto_PP2Bcyto_on | included |
| D3497nuc_PP2Bnuc_off | included |
| D3497cyto2nuc_passive | included |
| D34nuc2cyto_passive | included |
| D97cyto_PKAcyto_cyto2nuc | included |
| D3497nuc_PP2Apnuc_off | included |
| PP2Apnucdephosphorylation | included |
| PP1nuc_D3497nuc_on | included |
| D97cyto_PKAcyto_on | included |
| PP1cyto_D34cyto_on | included |
| D97cyto2nuc | included |
| Dnuc_PKAnuc_off | included |
| cAMP_cAMP3_R2C2_onoff | included |
| D3497cyto_PP2Apcyto_cyto2nuc | included |
| D3497nuc_PP2Apnuc_nuc2cyto | included |
| D97cyto_PKAcyto_cat | included |
| D97nuc_PKAnuc_off | included |
| cAMP_PDE10A_onoff | included |
Simulations - cAMPinput_secondary2 go to Specifications
| Name | End Time | Output Options |
|---|---|---|
| cAMPsecondaryMiddle2 | 3600.0 |
OutputTimeStep 5.0 |
cAMPinput_secondary2 Universal ID's
cAMPinput_secondary2 Text Annotations
Assignments
| Name | Variable | Assignment Function Expression |
|---|
Events
| Name | Trigger Type | Variable Assignment |
|---|
Geometry Geometry1760091997
(Origin: 0.0, -14.0, 0.0; Extent: 155.0, 40.0, 11.0 [um])
| Dimension | Type | Subdomain | Adjacent Subvolumes | Size | Mapped Compartment |
|---|---|---|---|---|---|
| Volume | Analytical | subdomain2 | 301.60068965661543 [um3] | nucleus | |
| Volume | Analytical | subdomain1 | 1202.1930494498022 [um3] | cytosol | |
| Volume | Analytical | subdomain0 | 66696.20626089358 [um3] | c0 | |
| Surface | subdomain0_subdomain1_membrane | subdomain0 | subdomain1 | 1432.4688299433924 [um2] | cellmembrane | |
| Surface | subdomain1_subdomain2_membrane | subdomain1 | subdomain2 | 211.84616618489457 [um2] | nucleusmembrane |
Events
| Name | Variable | Rate Expression |
|---|
Specifications (Species) - cAMPinput_tertiary1 go to Simulations
| Species | Initial Condition | Diffusion Constant | Structure |
|---|---|---|---|
| cAMPsource | (200.0 * (((x >= 110.5) && (x <= 112.3) && (y >= - 12.0) && (y <= - 10.5) && (z >= 5.0) && (z <= 6.0)) + ((x >= 112.5) && (x <= 112.8) && (y >= - 12.0) && (y <= - 10.5) && (z >= 5.0) && (z <= 5.5))) * (t < 5.0)) [uM] | 0.0 [um2/s] | cytosol |
| D3497cyto | 0.0 [uM] | D_d32 [um2/s] | cytosol |
| PP1cyto | 5.0 [uM] | D_pp1 [um2/s] | cytosol |
| PP1cyto_D34cyto | 0.0 [uM] | D_d32pp1 [um2/s] | cytosol |
| Dcyto | 0.0 [uM] | D_d32 [um2/s] | cytosol |
| D97cyto_PP2Apcyto | 0.0 [uM] | D_d32pp2a [um2/s] | cytosol |
| R2 | 0.0 [uM] | D_r2 [um2/s] | cytosol |
| PP2Bcyto | 1.6 [uM] | D_pp2b [um2/s] | cytosol |
| PP1cyto_D3497cyto_PP2Bcyto | 0.0 [uM] | D_d32pp1pp2b [um2/s] | cytosol |
| PDE10A | 1.0 [uM] | D_pde10a [um2/s] | cytosol |
| cAMP_PDE10A | 0.0 [uM] | D_pde10a [um2/s] | cytosol |
| D97cyto_PKAcyto | 0.0 [uM] | D_d32pkac [um2/s] | cytosol |
| PP1cyto_D34cyto_PP2Bcyto | 0.0 [uM] | D_d32pp1pp2b [um2/s] | cytosol |
| AMP | 0.0 [uM] | 0.0 [um2/s] | cytosol |
| cAMP | 0.0 [uM] | 100.0 [um2/s] | cytosol |
| DMNB_cAMP | 0.0 [uM] | 100.0 [um2/s] | cytosol |
| light_spot | 0.0 [uM] | 0.0 [um2/s] | cytosol |
| R2C | 0.0 [uM] | D_r2c [um2/s] | cytosol |
| cAMP4_R2C2 | 0.0 [uM] | D_r2c2 [um2/s] | cytosol |
| cAMP4_R2C | 0.0 [uM] | D_r2c [um2/s] | cytosol |
| cAMP3_R2C2 | 0.0 [uM] | D_r2c2 [um2/s] | cytosol |
| cAMP_R2C2 | 0.0 [uM] | D_r2c2 [um2/s] | cytosol |
| cAMP2_R2C2 | 0.0 [uM] | D_r2c2 [um2/s] | cytosol |
| D34cyto_PP2Bcyto | 0.0 [uM] | D_d32pp2b [um2/s] | cytosol |
| PKAcyto | 0.0 [uM] | D_pkac [um2/s] | cytosol |
| D3497cyto_PP2Apcyto | 0.0 [uM] | D_d32pp2a [um2/s] | cytosol |
| Dcyto_PKAcyto | 0.0 [uM] | D_d32pkac [um2/s] | cytosol |
| PP2Acyto_PKAcyto | 0.0 [uM] | D_pp2apka [um2/s] | cytosol |
| PP2Acyto | 2.0 [uM] | D_pp2a [um2/s] | cytosol |
| cAMP4_R2 | 0.0 [uM] | D_r2 [um2/s] | cytosol |
| PP2Apcyto | 0.0 [uM] | D_pp2a [um2/s] | cytosol |
| D97cyto | 50.0 [uM] | D_d32 [um2/s] | cytosol |
| PP1cyto_D3497cyto | 0.0 [uM] | D_d32pp1 [um2/s] | cytosol |
| D34cyto | 0.0 [uM] | D_d32 [um2/s] | cytosol |
| R2C2 | 1.0 [uM] | D_r2c2 [um2/s] | cytosol |
| D3497cyto_PP2Bcyto | 0.0 [uM] | D_d32pp2b [um2/s] | cytosol |
| PP2Anuc | 2.0 [uM] | D_pp2a [um2/s] | nucleus |
| Dnuc_PKAnuc | 0.0 [uM] | D_d32pkac [um2/s] | nucleus |
| D97nuc_PP2Apnuc | 0.0 [uM] | D_d32pp2a [um2/s] | nucleus |
| PP1nuc_D34nuc_PP2Bnuc | 0.0 [uM] | D_d32pp1pp2b [um2/s] | nucleus |
| D34nuc_CK2 | 0.0 [uM] | D_d32ck2 [um2/s] | nucleus |
| Dnuc_CK2 | 0.0 [uM] | D_d32ck2 [um2/s] | nucleus |
| PP2Anuc_PKAnuc | 0.0 [uM] | D_pp2apka [um2/s] | nucleus |
| Dnuc | 0.0 [uM] | D_d32 [um2/s] | nucleus |
| D34nuc_PP2Bnuc | 0.0 [uM] | D_d32pp2b [um2/s] | nucleus |
| PP1nuc | 5.0 [uM] | D_pp1 [um2/s] | nucleus |
| PP1nuc_D34nuc | 0.0 [uM] | D_d32pp1 [um2/s] | nucleus |
| PP1nuc_D3497nuc | 0.0 [uM] | D_d32pp1 [um2/s] | nucleus |
| PP1nuc_D3497nuc_PP2Bnuc | 0.0 [uM] | D_d32pp1pp2b [um2/s] | nucleus |
| D3497nuc_PP2Apnuc | 0.0 [uM] | D_d32pp2a [um2/s] | nucleus |
| D97nuc | 30.0 [uM] | D_d32 [um2/s] | nucleus |
| D3497nuc_PP2Bnuc | 0.0 [uM] | D_d32pp2b [um2/s] | nucleus |
| CK2 | 1.0 [uM] | D_ck2 [um2/s] | nucleus |
| PP2Apnuc | 0.0 [uM] | D_pp2a [um2/s] | nucleus |
| PP2Bnuc | 1.6 [uM] | D_pp2b [um2/s] | nucleus |
| D34nuc | 0.0 [uM] | D_d32 [um2/s] | nucleus |
| D3497nuc | 0.0 [uM] | D_d32 [um2/s] | nucleus |
| PKAnuc | 0.0 [uM] | D_pkac [um2/s] | nucleus |
| D97nuc_PKAnuc | 0.0 [uM] | D_d32pkac [um2/s] | nucleus |
Specifications (Reaction) - cAMPinput_tertiary1 go to Simulations
| Name | Enabled? |
|---|---|
| PP1nuc_D34nuc_off | included |
| D3497cyto_PP2Bcyto_off | included |
| PP1nuc_D3497nuc_off | included |
| PP1cyto_D34cyto_PP2Bcyto_cyto2nuc | included |
| PP2Apcyto2nuc | included |
| D97cyto_PKAcyto_off | included |
| PP1cyto_D3497cyto_PP2Bcyto_cyto2nuc | included |
| D97cyto_PP2Apcyto_off | included |
| D97nuc2cyto | included |
| D3497cyto_PP2Apcyto_on | included |
| Dcyto2nuc_passive | included |
| D34cyto2nuc_passive | included |
| D3497cyto_PP2Bcyto_on | included |
| PP1nuc_D34nuc_nuc2cyto | included |
| Dnuc_CK2_cat | included |
| D3497nuc2cyto | included |
| D97nuc_PKAnuc_cat | included |
| PP2Anuc_PKAnuc_cat | included |
| D97nuc_PP2Apnuc_cat | included |
| PP1nuc_D3497nuc_PP2Bnuc_cat | included |
| PP1nuc_D3497nuc_PP2Bnuc_off | included |
| PP1cyto_D34cyto_PP2Bcyto_cat | included |
| D3497cyto2nuc | included |
| D3497nuc2cyto_passive | included |
| D3497nuc_PP2Bnuc_on | included |
| PP2Anuc2cyto | included |
| PP2Acyto_PKAcyto_cat | included |
| PP2Acyto_PKAcyto_off | included |
| D34nuc_CK2_cat | included |
| Dnuc2cyto_passive | included |
| Dnuc_CK2_off | included |
| photoUncaging_DMNB_cAMP | included |
| Dcyto_PKAcyto_on | included |
| Dnuc_PKAnuc_cat | included |
| D97nuc_PKAnuc_on | included |
| D3497cyto_PP2Bcyto_cyto2nuc | included |
| PP1cyto_D34cyto_PP2Bcyto_on | included |
| D34nuc_PP2Bnuc_on | included |
| R2_PKAcyto_bind | included |
| Dcyto_PKAcyto_off | included |
| D3497cyto_PP2Apcyto_cat | included |
| PP2Anuc_PKAnuc_on | included |
| PP2Bnuc2cyto | included |
| PP2Acyto_PKAcyto_on | included |
| PP1nuc_D3497nuc_PP2Bnuc_on | included |
| R2C_PKAcyto_bind | included |
| PP1cyto_D3497_off | included |
| D3497cyto_PP2Bcyto_cat | included |
| PP1nuc_D34nuc_PP2Bnuc_cat | included |
| PP1nuc_D34nuc_on | included |
| Dcyto_PKAcyto_cat | included |
| PP1cyto_D34cyto_PP2Bcyto_off | included |
| D97cyto_PP2Apcyto_cyto2nuc | included |
| Dnuc_CK2_on | included |
| PP1cyto_D34cyto_cyto2nuc | included |
| D3497nuc_PP2Bnuc_nuc2cyto | included |
| D3497nuc_PP2Apnuc_cat | included |
| D34nuc_PP2Bnuc_cat | included |
| Dcyto2nuc | included |
| cAMPsource2cAMP | included |
| D97nuc_PKAnuc_nuc2cyto | included |
| cAMP_PDE10A_cat | included |
| PP1cyto_D34cyto_off | included |
| PKAnuc2cyto | included |
| D3497nuc_PP2Apnuc_on | included |
| Dnuc_PKAnuc_on | included |
| D34cyto_PP2Bcyto_off | included |
| D3497cyto_PP2Apcyto_off | included |
| PP1cyto2nuc | included |
| D34nuc_CK2_off | included |
| PP1nuc_D34nuc_PP2Bnuc_off | included |
| PP1nuc_D3497nuc_PP2Bnuc_nuc2cyto | included |
| D97cyto_PP2Apcyto_on | included |
| cAMP4_R2_releasecAMP | included |
| PP2Anuc_PKAnuc_nuc2cyto | included |
| D34nuc_PP2Bnuc_off | included |
| D97cyto_PP2Apcyto_cat | included |
| PP1cyto_D3497cyto_PP2Bcyto_cat | included |
| cAMP_R2C2_onoff | included |
| D3497nuc_PP2Bnuc_cat | included |
| D34nuc_CK2_on | included |
| D97nuc_PP2Apnuc_off | included |
| D34cyto_PP2Bcyto_cyto2nuc | included |
| cAMP4_R2C_PKA_onoff | included |
| cAMP_cAMP2_R2C2_onoff | included |
| cAMP4_R2_PKA_onoff | included |
| D97nuc2cyto_passive | included |
| Dcyto_PKAcyto_cyto2nuc | included |
| PP2Apnuc2cyto | included |
| PP2Anuc_PKANuc_off | included |
| PKAcyto2nuc | included |
| PP2Acyto_PKAcyto_cyto2nuc | included |
| PP1cyto_D3497cyto_on | included |
| D97nuc_PP2Apnuc_nuc2cyto | included |
| PP2Apcytodephosphorylation | included |
| PP2Bcyto2nuc | included |
| PP1cyto_D3497cyto_PP2Bcyto_on | included |
| PP1nuc_D34nuc_PP2Bnuc_on | included |
| D97nuc_PP2Apnuc_on | included |
| D34cyto2nuc | included |
| PP2Acyto2nuc | included |
| PP1cyto_D3497cyto_PP2Bcyto_off | included |
| PP1nuc2cyto | included |
| D97cyto2nuc_passive | included |
| cAMP_cAMP_R2C2_onoff | included |
| PP1cyto_D3497cyto_cyto2nuc | included |
| PP1nuc_D3497nuc_nuc2cyto | included |
| D34cyto_PP2Bcyto_cat | included |
| D34cyto_PP2Bcyto_on | included |
| D3497nuc_PP2Bnuc_off | included |
| D3497cyto2nuc_passive | included |
| D34nuc2cyto_passive | included |
| D97cyto_PKAcyto_cyto2nuc | included |
| D3497nuc_PP2Apnuc_off | included |
| PP2Apnucdephosphorylation | included |
| PP1nuc_D3497nuc_on | included |
| D97cyto_PKAcyto_on | included |
| PP1cyto_D34cyto_on | included |
| D97cyto2nuc | included |
| Dnuc_PKAnuc_off | included |
| cAMP_cAMP3_R2C2_onoff | included |
| D3497cyto_PP2Apcyto_cyto2nuc | included |
| D3497nuc_PP2Apnuc_nuc2cyto | included |
| D97cyto_PKAcyto_cat | included |
| D97nuc_PKAnuc_off | included |
| cAMP_PDE10A_onoff | included |
Simulations - cAMPinput_tertiary1 go to Specifications
| Name | End Time | Output Options |
|---|---|---|
| cAMPtertiaryMiddle1 | 3600.0 |
OutputTimeStep 5.0 |
cAMPinput_tertiary1 Universal ID's
cAMPinput_tertiary1 Text Annotations
Assignments
| Name | Variable | Assignment Function Expression |
|---|
Events
| Name | Trigger Type | Variable Assignment |
|---|
Geometry Geometry1760091997
(Origin: 0.0, -14.0, 0.0; Extent: 155.0, 40.0, 11.0 [um])
| Dimension | Type | Subdomain | Adjacent Subvolumes | Size | Mapped Compartment |
|---|---|---|---|---|---|
| Volume | Analytical | subdomain2 | 301.60068965661543 [um3] | nucleus | |
| Volume | Analytical | subdomain1 | 1202.1930494498022 [um3] | cytosol | |
| Volume | Analytical | subdomain0 | 66696.20626089358 [um3] | c0 | |
| Surface | subdomain0_subdomain1_membrane | subdomain0 | subdomain1 | 1432.4688299433924 [um2] | cellmembrane | |
| Surface | subdomain1_subdomain2_membrane | subdomain1 | subdomain2 | 211.84616618489457 [um2] | nucleusmembrane |
Events
| Name | Variable | Rate Expression |
|---|
Specifications (Species) - cAMPinput_tertiary2 go to Simulations
| Species | Initial Condition | Diffusion Constant | Structure |
|---|---|---|---|
| cAMPsource | (200.0 * (((x >= 130.5) && (x <= 132.3) && (y >= - 12.0) && (y <= - 10.5) && (z >= 5.0) && (z <= 6.0)) + ((x >= 132.5) && (x <= 132.8) && (y >= - 12.0) && (y <= - 10.5) && (z >= 5.0) && (z <= 5.5))) * (t < 5.0)) [uM] | 0.0 [um2/s] | cytosol |
| D3497cyto | 0.0 [uM] | D_d32 [um2/s] | cytosol |
| PP1cyto | 5.0 [uM] | D_pp1 [um2/s] | cytosol |
| PP1cyto_D34cyto | 0.0 [uM] | D_d32pp1 [um2/s] | cytosol |
| Dcyto | 0.0 [uM] | D_d32 [um2/s] | cytosol |
| D97cyto_PP2Apcyto | 0.0 [uM] | D_d32pp2a [um2/s] | cytosol |
| R2 | 0.0 [uM] | D_r2 [um2/s] | cytosol |
| PP2Bcyto | 1.6 [uM] | D_pp2b [um2/s] | cytosol |
| PP1cyto_D3497cyto_PP2Bcyto | 0.0 [uM] | D_d32pp1pp2b [um2/s] | cytosol |
| PDE10A | 1.0 [uM] | D_pde10a [um2/s] | cytosol |
| cAMP_PDE10A | 0.0 [uM] | D_pde10a [um2/s] | cytosol |
| D97cyto_PKAcyto | 0.0 [uM] | D_d32pkac [um2/s] | cytosol |
| PP1cyto_D34cyto_PP2Bcyto | 0.0 [uM] | D_d32pp1pp2b [um2/s] | cytosol |
| AMP | 0.0 [uM] | 0.0 [um2/s] | cytosol |
| cAMP | 0.0 [uM] | 100.0 [um2/s] | cytosol |
| DMNB_cAMP | 0.0 [uM] | 100.0 [um2/s] | cytosol |
| light_spot | 0.0 [uM] | 0.0 [um2/s] | cytosol |
| R2C | 0.0 [uM] | D_r2c [um2/s] | cytosol |
| cAMP4_R2C2 | 0.0 [uM] | D_r2c2 [um2/s] | cytosol |
| cAMP4_R2C | 0.0 [uM] | D_r2c [um2/s] | cytosol |
| cAMP3_R2C2 | 0.0 [uM] | D_r2c2 [um2/s] | cytosol |
| cAMP_R2C2 | 0.0 [uM] | D_r2c2 [um2/s] | cytosol |
| cAMP2_R2C2 | 0.0 [uM] | D_r2c2 [um2/s] | cytosol |
| D34cyto_PP2Bcyto | 0.0 [uM] | D_d32pp2b [um2/s] | cytosol |
| PKAcyto | 0.0 [uM] | D_pkac [um2/s] | cytosol |
| D3497cyto_PP2Apcyto | 0.0 [uM] | D_d32pp2a [um2/s] | cytosol |
| Dcyto_PKAcyto | 0.0 [uM] | D_d32pkac [um2/s] | cytosol |
| PP2Acyto_PKAcyto | 0.0 [uM] | D_pp2apka [um2/s] | cytosol |
| PP2Acyto | 2.0 [uM] | D_pp2a [um2/s] | cytosol |
| cAMP4_R2 | 0.0 [uM] | D_r2 [um2/s] | cytosol |
| PP2Apcyto | 0.0 [uM] | D_pp2a [um2/s] | cytosol |
| D97cyto | 50.0 [uM] | D_d32 [um2/s] | cytosol |
| PP1cyto_D3497cyto | 0.0 [uM] | D_d32pp1 [um2/s] | cytosol |
| D34cyto | 0.0 [uM] | D_d32 [um2/s] | cytosol |
| R2C2 | 1.0 [uM] | D_r2c2 [um2/s] | cytosol |
| D3497cyto_PP2Bcyto | 0.0 [uM] | D_d32pp2b [um2/s] | cytosol |
| PP2Anuc | 2.0 [uM] | D_pp2a [um2/s] | nucleus |
| Dnuc_PKAnuc | 0.0 [uM] | D_d32pkac [um2/s] | nucleus |
| D97nuc_PP2Apnuc | 0.0 [uM] | D_d32pp2a [um2/s] | nucleus |
| PP1nuc_D34nuc_PP2Bnuc | 0.0 [uM] | D_d32pp1pp2b [um2/s] | nucleus |
| D34nuc_CK2 | 0.0 [uM] | D_d32ck2 [um2/s] | nucleus |
| Dnuc_CK2 | 0.0 [uM] | D_d32ck2 [um2/s] | nucleus |
| PP2Anuc_PKAnuc | 0.0 [uM] | D_pp2apka [um2/s] | nucleus |
| Dnuc | 0.0 [uM] | D_d32 [um2/s] | nucleus |
| D34nuc_PP2Bnuc | 0.0 [uM] | D_d32pp2b [um2/s] | nucleus |
| PP1nuc | 5.0 [uM] | D_pp1 [um2/s] | nucleus |
| PP1nuc_D34nuc | 0.0 [uM] | D_d32pp1 [um2/s] | nucleus |
| PP1nuc_D3497nuc | 0.0 [uM] | D_d32pp1 [um2/s] | nucleus |
| PP1nuc_D3497nuc_PP2Bnuc | 0.0 [uM] | D_d32pp1pp2b [um2/s] | nucleus |
| D3497nuc_PP2Apnuc | 0.0 [uM] | D_d32pp2a [um2/s] | nucleus |
| D97nuc | 30.0 [uM] | D_d32 [um2/s] | nucleus |
| D3497nuc_PP2Bnuc | 0.0 [uM] | D_d32pp2b [um2/s] | nucleus |
| CK2 | 1.0 [uM] | D_ck2 [um2/s] | nucleus |
| PP2Apnuc | 0.0 [uM] | D_pp2a [um2/s] | nucleus |
| PP2Bnuc | 1.6 [uM] | D_pp2b [um2/s] | nucleus |
| D34nuc | 0.0 [uM] | D_d32 [um2/s] | nucleus |
| D3497nuc | 0.0 [uM] | D_d32 [um2/s] | nucleus |
| PKAnuc | 0.0 [uM] | D_pkac [um2/s] | nucleus |
| D97nuc_PKAnuc | 0.0 [uM] | D_d32pkac [um2/s] | nucleus |
Specifications (Reaction) - cAMPinput_tertiary2 go to Simulations
| Name | Enabled? |
|---|---|
| PP1nuc_D34nuc_off | included |
| D3497cyto_PP2Bcyto_off | included |
| PP1nuc_D3497nuc_off | included |
| PP1cyto_D34cyto_PP2Bcyto_cyto2nuc | included |
| PP2Apcyto2nuc | included |
| D97cyto_PKAcyto_off | included |
| PP1cyto_D3497cyto_PP2Bcyto_cyto2nuc | included |
| D97cyto_PP2Apcyto_off | included |
| D97nuc2cyto | included |
| D3497cyto_PP2Apcyto_on | included |
| Dcyto2nuc_passive | included |
| D34cyto2nuc_passive | included |
| D3497cyto_PP2Bcyto_on | included |
| PP1nuc_D34nuc_nuc2cyto | included |
| Dnuc_CK2_cat | included |
| D3497nuc2cyto | included |
| D97nuc_PKAnuc_cat | included |
| PP2Anuc_PKAnuc_cat | included |
| D97nuc_PP2Apnuc_cat | included |
| PP1nuc_D3497nuc_PP2Bnuc_cat | included |
| PP1nuc_D3497nuc_PP2Bnuc_off | included |
| PP1cyto_D34cyto_PP2Bcyto_cat | included |
| D3497cyto2nuc | included |
| D3497nuc2cyto_passive | included |
| D3497nuc_PP2Bnuc_on | included |
| PP2Anuc2cyto | included |
| PP2Acyto_PKAcyto_cat | included |
| PP2Acyto_PKAcyto_off | included |
| D34nuc_CK2_cat | included |
| Dnuc2cyto_passive | included |
| Dnuc_CK2_off | included |
| photoUncaging_DMNB_cAMP | included |
| Dcyto_PKAcyto_on | included |
| Dnuc_PKAnuc_cat | included |
| D97nuc_PKAnuc_on | included |
| D3497cyto_PP2Bcyto_cyto2nuc | included |
| PP1cyto_D34cyto_PP2Bcyto_on | included |
| D34nuc_PP2Bnuc_on | included |
| R2_PKAcyto_bind | included |
| Dcyto_PKAcyto_off | included |
| D3497cyto_PP2Apcyto_cat | included |
| PP2Anuc_PKAnuc_on | included |
| PP2Bnuc2cyto | included |
| PP2Acyto_PKAcyto_on | included |
| PP1nuc_D3497nuc_PP2Bnuc_on | included |
| R2C_PKAcyto_bind | included |
| PP1cyto_D3497_off | included |
| D3497cyto_PP2Bcyto_cat | included |
| PP1nuc_D34nuc_PP2Bnuc_cat | included |
| PP1nuc_D34nuc_on | included |
| Dcyto_PKAcyto_cat | included |
| PP1cyto_D34cyto_PP2Bcyto_off | included |
| D97cyto_PP2Apcyto_cyto2nuc | included |
| Dnuc_CK2_on | included |
| PP1cyto_D34cyto_cyto2nuc | included |
| D3497nuc_PP2Bnuc_nuc2cyto | included |
| D3497nuc_PP2Apnuc_cat | included |
| D34nuc_PP2Bnuc_cat | included |
| Dcyto2nuc | included |
| cAMPsource2cAMP | included |
| D97nuc_PKAnuc_nuc2cyto | included |
| cAMP_PDE10A_cat | included |
| PP1cyto_D34cyto_off | included |
| PKAnuc2cyto | included |
| D3497nuc_PP2Apnuc_on | included |
| Dnuc_PKAnuc_on | included |
| D34cyto_PP2Bcyto_off | included |
| D3497cyto_PP2Apcyto_off | included |
| PP1cyto2nuc | included |
| D34nuc_CK2_off | included |
| PP1nuc_D34nuc_PP2Bnuc_off | included |
| PP1nuc_D3497nuc_PP2Bnuc_nuc2cyto | included |
| D97cyto_PP2Apcyto_on | included |
| cAMP4_R2_releasecAMP | included |
| PP2Anuc_PKAnuc_nuc2cyto | included |
| D34nuc_PP2Bnuc_off | included |
| D97cyto_PP2Apcyto_cat | included |
| PP1cyto_D3497cyto_PP2Bcyto_cat | included |
| cAMP_R2C2_onoff | included |
| D3497nuc_PP2Bnuc_cat | included |
| D34nuc_CK2_on | included |
| D97nuc_PP2Apnuc_off | included |
| D34cyto_PP2Bcyto_cyto2nuc | included |
| cAMP4_R2C_PKA_onoff | included |
| cAMP_cAMP2_R2C2_onoff | included |
| cAMP4_R2_PKA_onoff | included |
| D97nuc2cyto_passive | included |
| Dcyto_PKAcyto_cyto2nuc | included |
| PP2Apnuc2cyto | included |
| PP2Anuc_PKANuc_off | included |
| PKAcyto2nuc | included |
| PP2Acyto_PKAcyto_cyto2nuc | included |
| PP1cyto_D3497cyto_on | included |
| D97nuc_PP2Apnuc_nuc2cyto | included |
| PP2Apcytodephosphorylation | included |
| PP2Bcyto2nuc | included |
| PP1cyto_D3497cyto_PP2Bcyto_on | included |
| PP1nuc_D34nuc_PP2Bnuc_on | included |
| D97nuc_PP2Apnuc_on | included |
| D34cyto2nuc | included |
| PP2Acyto2nuc | included |
| PP1cyto_D3497cyto_PP2Bcyto_off | included |
| PP1nuc2cyto | included |
| D97cyto2nuc_passive | included |
| cAMP_cAMP_R2C2_onoff | included |
| PP1cyto_D3497cyto_cyto2nuc | included |
| PP1nuc_D3497nuc_nuc2cyto | included |
| D34cyto_PP2Bcyto_cat | included |
| D34cyto_PP2Bcyto_on | included |
| D3497nuc_PP2Bnuc_off | included |
| D3497cyto2nuc_passive | included |
| D34nuc2cyto_passive | included |
| D97cyto_PKAcyto_cyto2nuc | included |
| D3497nuc_PP2Apnuc_off | included |
| PP2Apnucdephosphorylation | included |
| PP1nuc_D3497nuc_on | included |
| D97cyto_PKAcyto_on | included |
| PP1cyto_D34cyto_on | included |
| D97cyto2nuc | included |
| Dnuc_PKAnuc_off | included |
| cAMP_cAMP3_R2C2_onoff | included |
| D3497cyto_PP2Apcyto_cyto2nuc | included |
| D3497nuc_PP2Apnuc_nuc2cyto | included |
| D97cyto_PKAcyto_cat | included |
| D97nuc_PKAnuc_off | included |
| cAMP_PDE10A_onoff | included |
Simulations - cAMPinput_tertiary2 go to Specifications
| Name | End Time | Output Options |
|---|---|---|
| cAMPtertiaryMiddle2 | 3600.0 |
OutputTimeStep 5.0 |
cAMPinput_tertiary2 Universal ID's
cAMPinput_tertiary2 Text Annotations
Assignments
| Name | Variable | Assignment Function Expression |
|---|
Events
| Name | Trigger Type | Variable Assignment |
|---|
Geometry Geometry1760091997
(Origin: 0.0, -14.0, 0.0; Extent: 155.0, 40.0, 11.0 [um])
| Dimension | Type | Subdomain | Adjacent Subvolumes | Size | Mapped Compartment |
|---|---|---|---|---|---|
| Volume | Analytical | subdomain2 | 301.60068965661543 [um3] | nucleus | |
| Volume | Analytical | subdomain1 | 1202.1930494498022 [um3] | cytosol | |
| Volume | Analytical | subdomain0 | 66696.20626089358 [um3] | c0 | |
| Surface | subdomain0_subdomain1_membrane | subdomain0 | subdomain1 | 1432.4688299433924 [um2] | cellmembrane | |
| Surface | subdomain1_subdomain2_membrane | subdomain1 | subdomain2 | 211.84616618489457 [um2] | nucleusmembrane |
Events
| Name | Variable | Rate Expression |
|---|
Global Parameters
| Name | Expression |
|---|---|
| D_PKA_kon | 5.6[uM-1.s-1] |
| D_PKA_koff | 10.8[s-1] |
| D_PKA_kcat | 2.7[s-1] |
| D34_PP2B_kon | 4.1[uM-1.s-1] |
| D34_PP2B_koff | 6.4[s-1] |
| D34_PP2B_kcat | 0.1[s-1] |
| D_CK2_kon | 3.0[uM-1.s-1] |
| D_CK2_koff | 10.0[s-1] |
| D_CK2_kcat | 0.32[s-1] |
| D97_PP2Ap_kon | 2.7[uM-1.s-1] |
| D97_PP2Ap_koff | 4.45[s-1] |
| D97_PP2Ap_kcat | 0.2[s-1] |
| PP1_D34_kon | 40.0[uM-1.s-1] |
| PP1_D34_koff | 0.4[s-1] |
| kD97nuc2cyto | 133.6313[molecules.um-2.uM-1.s-1] |
| kDcyto2nuc | 80.0[molecules.um-2.uM-1.s-1] |
| kfastnuc2cyto | 0.7[tbd] |
| kfastcyto2nuc | 0.7[tbd] |
| PP2A_PKA_kon | 2.4[uM-1.s-1] |
| PP2A_PKA_koff | 0.1[s-1] |
| PP2A_PKA_kcat | 0.3[s-1] |
| gDnuctotal | (Dnuc + D34nuc + D97nuc + D3497nuc + Dnuc_PKAnuc + D97nuc_PKAnuc + D34nuc_PP2Bnuc + D3497nuc_PP2Bnuc + D97nuc_PP2Apnuc + D3497nuc_PP2Apnuc + Dnuc_CK2 + D34nuc_CK2 + PP1nuc_D34nuc + PP1nuc_D3497nuc + PP1nuc_D34nuc_PP2Bnuc + PP1nuc_D3497nuc_PP2Bnuc)[uM] |
| gDcytototal | (Dcyto + D34cyto + D97cyto + D3497cyto + Dcyto_PKAcyto + D97cyto_PKAcyto + D34cyto_PP2Bcyto + D3497cyto_PP2Bcyto + D97cyto_PP2Apcyto + D3497cyto_PP2Apcyto + PP1cyto_D34cyto + PP1cyto_D3497cyto + PP1cyto_D34cyto_PP2Bcyto + PP1cyto_D3497cyto_PP2Bcyto)[uM] |
| gD34total | (D34cyto + D34nuc + D3497cyto + D3497nuc + D34cyto_PP2Bcyto + D34nuc_PP2Bnuc + D3497cyto_PP2Bcyto + D3497nuc_PP2Bnuc + D3497cyto_PP2Apcyto + D3497nuc_PP2Apnuc + D34nuc_CK2 + PP1nuc_D34nuc + PP1nuc_D3497nuc + PP1cyto_D34cyto + PP1cyto_D3497cyto + PP1cyto_D34cyto_PP2Bcyto + PP1cyto_D3497cyto_PP2Bcyto + PP1nuc_D34nuc_PP2Bnuc + PP1nuc_D3497nuc_PP2Bnuc)[uM] |
| gD34nuctotal | (D34nuc + D3497nuc + D34nuc_PP2Bnuc + D3497nuc_PP2Bnuc + D3497nuc_PP2Apnuc + D34nuc_CK2 + PP1nuc_D34nuc + PP1nuc_D3497nuc + PP1nuc_D34nuc_PP2Bnuc + PP1nuc_D3497nuc_PP2Bnuc)[uM] |
| gD34cytototal | (D34cyto + D3497cyto + D34cyto_PP2Bcyto + D3497cyto_PP2Bcyto + D3497cyto_PP2Apcyto + PP1cyto_D34cyto + PP1cyto_D3497cyto + PP1cyto_D34cyto_PP2Bcyto + PP1cyto_D3497cyto_PP2Bcyto)[uM] |
| gD97total | (D97cyto + D97nuc + D3497cyto + D3497nuc + D97cyto_PKAcyto + D97nuc_PKAnuc + D3497cyto_PP2Bcyto + D3497nuc_PP2Bnuc + D97cyto_PP2Apcyto + D97nuc_PP2Apnuc + D3497cyto_PP2Apcyto + D3497nuc_PP2Apnuc + PP1nuc_D3497nuc + PP1cyto_D3497cyto + PP1cyto_D3497cyto_PP2Bcyto + PP1nuc_D3497nuc_PP2Bnuc)[uM] |
| gD97nuctotal | (D97nuc + D3497nuc + D97nuc_PKAnuc + D3497nuc_PP2Bnuc + D97nuc_PP2Apnuc + D3497nuc_PP2Apnuc + PP1nuc_D3497nuc + PP1nuc_D3497nuc_PP2Bnuc)[uM] |
| gD97cytototal | (D97cyto + D3497cyto + D97cyto_PKAcyto + D3497cyto_PP2Bcyto + D97cyto_PP2Apcyto + D3497cyto_PP2Apcyto + PP1cyto_D3497cyto + PP1cyto_D3497cyto_PP2Bcyto)[uM] |
| gDncratio | ((Dnuc + D34nuc + D97nuc + D3497nuc + Dnuc_PKAnuc + D97nuc_PKAnuc + D34nuc_PP2Bnuc + D3497nuc_PP2Bnuc + D97nuc_PP2Apnuc + D3497nuc_PP2Apnuc + Dnuc_CK2 + D34nuc_CK2 + PP1nuc_D34nuc + PP1nuc_D3497nuc + PP1nuc_D34nuc_PP2Bnuc + PP1nuc_D3497nuc_PP2Bnuc) / (Dcyto + D34cyto + D97cyto + D3497cyto + Dcyto_PKAcyto + D97cyto_PKAcyto + D34cyto_PP2Bcyto + D3497cyto_PP2Bcyto + D97cyto_PP2Apcyto + D3497cyto_PP2Apcyto + PP1cyto_D34cyto + PP1cyto_D3497cyto + PP1cyto_D34cyto_PP2Bcyto + PP1cyto_D3497cyto_PP2Bcyto))[tbd] |
| gPP1itotal | (PP1nuc_D3497nuc + PP1nuc_D34nuc + PP1cyto_D34cyto + PP1cyto_D3497cyto + PP1cyto_D34cyto_PP2Bcyto + PP1cyto_D3497cyto_PP2Bcyto + PP1nuc_D34nuc_PP2Bnuc + PP1nuc_D3497nuc_PP2Bnuc)[uM] |
| gPP1ibar | (0.625 * (PP1nuc_D3497nuc + PP1nuc_D34nuc + PP1cyto_D34cyto + PP1cyto_D3497cyto + PP1cyto_D34cyto_PP2Bcyto + PP1cyto_D3497cyto_PP2Bcyto + PP1nuc_D34nuc_PP2Bnuc + PP1nuc_D3497nuc_PP2Bnuc)) [tbd] |
| gPKAtotal | (PKAcyto + PKAnuc + PP2Acyto_PKAcyto + PP2Anuc_PKAnuc + Dcyto_PKAcyto + Dnuc_PKAnuc + D97cyto_PKAcyto + D97nuc_PKAnuc)[uM] |
| gPKAnuctotal | (PKAnuc + PP2Anuc_PKAnuc + Dnuc_PKAnuc + D97nuc_PKAnuc)[uM] |
| gPKAcytototal | (PKAcyto + PP2Acyto_PKAcyto + Dcyto_PKAcyto + D97cyto_PKAcyto)[uM] |
| gPP2Acytototal | (D3497cyto_PP2Apcyto + D97cyto_PP2Apcyto + PP2Acyto + PP2Acyto_PKAcyto + PP2Apcyto)[uM] |
| gPP2Anuctotal | (D3497nuc_PP2Apnuc + D97nuc_PP2Apnuc + PP2Anuc + PP2Anuc_PKAnuc + PP2Apnuc)[uM] |
| D_d32 | 7.0[um2.s-1] |
| D_pp2a | 3.6[um2.s-1] |
| D_pp2b | 4.7[um2.s-1] |
| D_pkac | 4.4[um2.s-1] |
| D_d32pkac | 3.8[um2.s-1] |
| D_d32pp2a | 3.4[um2.s-1] |
| D_d32pp2b | 4.3[um2.s-1] |
| D_r2c2 | 2.7[um2.s-1] |
| D_r2c | 3.0[um2.s-1] |
| D_r2 | 3.3[um2.s-1] |
| D_ck2 | 5.0[um2.s-1] |
| D_d32ck2 | 4.6[um2.s-1] |
| D_pp1 | 4.6[um2.s-1] |
| D_d32pp1 | 4.3[um2.s-1] |
| D_pp2apka | 2.5[um2.s-1] |
| D_d32pp1pp2b | 3.5[um2.s-1] |
| D_rc | 3.4[um2.s-1] |
| D_r | 4.1[um2.s-1] |
| cAMP_PDE10A_kon | 80.0[uM-1.s-1] |
| cAMP_PDE10A_koff | 16.8[s-1] |
| cAMP_PDE10A_kcat | 0.5[s-1] |
| kDcyto2nuc_passive | 1.62[molecules.um-2.uM-1.s-1] |
| kDnuc2cyto_passive | 1.62[molecules.um-2.uM-1.s-1] |
| D_pde10a | 5.0[um2.s-1] |
| gcAMPboundR2 | (cAMP_R2C2 + cAMP2_R2C2 + cAMP3_R2C2 + cAMP4_R2C2 + cAMP4_R2C + cAMP4_R2)[uM] |
| cAMP_R2C2_kon | 54.0[uM-1.s-1] |
| cAMP_R2C2_koff | 3.0[s-1] |
| cAMP_cAMPR2C2_kon | 54.0[uM-1.s-1] |
| cAMP_cAMPR2C2_koff | 3.0[s-1] |
| cAMP_cAMP2R2C2_kon | 75.0[uM-1.s-1] |
| cAMP_cAMP2R2C2_koff | 110.0[s-1] |
| cAMP_cAMP3R2C2_kon | 75.0[uM-1.s-1] |
| cAMP_cAMP3R2C2_koff | 110.0[s-1] |
| cAMP4R2C_PKA_kon | 18.0[uM-1.s-1] |
| cAMP4R2C_PKA_koff | 0.1[s-1] |
| cAMP4R2_PKA_kon | 18.0[uM-1.s-1] |
| cAMP4R2_PKA_koff | 0.1[s-1] |
| kPKAcyto2nuc_passive | 2.73[molecules.um-2.uM-1.s-1] |
| kPKAnuc2cyto_passive | 2.73[molecules.um-2.uM-1.s-1] |