Reaction Diagram
Physiology
Universal ID's | Text Annotations |
---|---|
|
|
Reaction |
Name
Structure
|
Kinetics | Depiction |
---|---|---|---|
CaM_Ca3+CalciumCaM_Ca4 |
091
IC
|
MassAction | CaM_Ca3+CalciumCaM_Ca4 |
|
|
reaction rate (J): (((Kf * CaM_Ca3) * Calcium) - (Kr * CaM_Ca4))[uM.s-1]
forward rate constant (Kf): 0.465[s-1.uM-1] reverse rate constant (Kr): 10.0[s-1] |
|
Int_TrkB2TrkB |
005
PM
|
MassAction | Int_TrkB2TrkB |
|
|
reaction rate (J): ((Kf * Int_TrkB2) - (Kr * TrkB))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 0.001[s-1] reverse rate constant (Kr): 0.001[s-1] |
|
CalciumCalcium_ER |
r44
ER_Membrane
|
GeneralKinetics | CalciumCalcium_ER |
|
|
reaction rate (J): (Kcat * SERCA_active * Calcium * Calcium / (0.0625 + (Calcium * Calcium)))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] user defined (Kcat): 10.0[s-1] |
|
PDE1+IBMXPDE1_IBMX |
r19
IC
|
MassAction | PDE1+IBMXPDE1_IBMX |
|
|
reaction rate (J): (((Kf * PDE1) * IBMX) - (Kr * PDE1_IBMX))[uM.s-1]
forward rate constant (Kf): 8.0[s-1.uM-1] reverse rate constant (Kr): 0.8[s-1] |
|
Da+D1LR_GqbyDa_D1LR_Gqby |
r20
PM
|
MassAction | Da+D1LR_GqbyDa_D1LR_Gqby |
|
|
reaction rate (J): (((Kf * Da) * D1LR_Gqby) - (Kr * Da_D1LR_Gqby))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 3.33[s-1.uM-1] reverse rate constant (Kr): 10.0[s-1] |
|
IP3_145IP3_14 |
r40
IC
|
HMMIrreversible | IP3_145IP3_14 |
|
|
reaction rate (J): ((Vmax * IP3_145) / (Km + IP3_145))[uM.s-1]
Km (1/2 max) (Km): 18.0[uM] max reaction rate (Vmax): (Kcat * IP3_5Pase2)[uM.s-1] user defined (Kcat): 10.667[s-1] |
|
DARPP32_PiDARPP32 |
057
IC
|
HMMIrreversible | DARPP32_PiDARPP32 |
|
|
reaction rate (J): ((Vmax * DARPP32_Pi) / (Km + DARPP32_Pi))[uM.s-1]
Km (1/2 max) (Km): 0.37[uM] max reaction rate (Vmax): (Kcat * PP2A_DI)[uM.s-1] user defined (Kcat): 6.7[s-1] |
|
Da_D1LR_GqbyG_by+Da_D1LR+Gq_GTP |
r28
PM
|
MassAction | Da_D1LR_GqbyG_by+Da_D1LR+Gq_GTP |
|
|
reaction rate (J): ((Kf * Da_D1LR_Gqby) - (((Kr * G_by) * Da_D1LR) * Gq_GTP))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 20.0[s-1] reverse rate constant (Kr): 0.0[um4.s-1.molecules-2] |
|
R2C_cAMP4PKA_active+R2_cAMP4 |
087
IC
|
MassAction | R2C_cAMP4PKA_active+R2_cAMP4 |
|
|
reaction rate (J): ((Kf * R2C_cAMP4) - ((Kr * PKA_active) * R2_cAMP4))[uM.s-1]
forward rate constant (Kf): 60.0[s-1] reverse rate constant (Kr): 18.0[s-1.uM-1] |
|
Rolipram+PDE4_ERK_PKAPDE4_Rolipram |
r10
IC
|
MassAction | Rolipram+PDE4_ERK_PKAPDE4_Rolipram |
|
|
reaction rate (J): (((Kf * Rolipram) * PDE4_ERK_PKA) - (Kr * PDE4_Rolipram))[uM.s-1]
forward rate constant (Kf): 1.0[s-1.uM-1] reverse rate constant (Kr): 0.019[s-1] |
|
AC5+FskAC5_Fsk |
r7
PM
|
MassAction | AC5+FskAC5_Fsk |
|
|
reaction rate (J): (((Kf * AC5) * Fsk) - (Kr * AC5_Fsk))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 0.026[s-1.uM-1] reverse rate constant (Kr): 1.0[s-1] |
|
IBMX+PDE4PDE4_IBMX |
r21
IC
|
MassAction | IBMX+PDE4PDE4_IBMX |
|
|
reaction rate (J): (((Kf * IBMX) * PDE4) - (Kr * PDE4_IBMX))[uM.s-1]
forward rate constant (Kf): 8.0[s-1.uM-1] reverse rate constant (Kr): 0.8[s-1] |
|
CaMKII_286CaMKII |
096
IC
|
HMMIrreversible | CaMKII_286CaMKII |
|
|
reaction rate (J): ((Vmax * CaMKII_286) / (Km + CaMKII_286))[uM.s-1]
Km (1/2 max) (Km): 5.1[uM] max reaction rate (Vmax): (Kcat * PP1)[uM.s-1] user defined (Kcat): 0.35[s-1] |
|
DARPP32DARPP32_Pi |
056
IC
|
HMMIrreversible | DARPP32DARPP32_Pi |
|
|
reaction rate (J): ((Vmax * DARPP32) / (Km + DARPP32))[uM.s-1]
Km (1/2 max) (Km): 2.4[uM] max reaction rate (Vmax): (Kcat * PKA_active)[uM.s-1] user defined (Kcat): 2.7[s-1] |
|
ERKERK_Tyr |
036
IC
|
HMMIrreversible | ERKERK_Tyr |
|
|
reaction rate (J): ((Vmax * ERK) / (Km + ERK))[uM.s-1]
Km (1/2 max) (Km): 0.046296[uM] max reaction rate (Vmax): (Kcat * MEK_active)[uM.s-1] user defined (Kcat): 0.15[s-1] |
|
Da+D1RDa_D1R |
064
PM
|
MassAction | Da+D1RDa_D1R |
|
|
reaction rate (J): (((Kf * Da) * D1R) - (Kr * Da_D1R))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 1.11[s-1.uM-1] reverse rate constant (Kr): 10.0[s-1] |
|
cAMPAMP |
r52
IC
|
HMMIrreversible | cAMPAMP |
|
|
reaction rate (J): ((Vmax * cAMP) / (Km + cAMP))[uM.s-1]
Km (1/2 max) (Km): 90.0[uM] max reaction rate (Vmax): (Kcat * PDEbg)[uM.s-1] user defined (Kcat): 20.0[s-1] |
|
cAMPAMP |
078
IC
|
HMMIrreversible | cAMPAMP |
|
|
reaction rate (J): ((Vmax * cAMP) / (Km + cAMP))[uM.s-1]
Km (1/2 max) (Km): 1.8[uM] max reaction rate (Vmax): (Kcat * PDE4_ERK_PKA)[uM.s-1] user defined (Kcat): 8.0[s-1] |
|
Four1N+GluR1_845_818GluR1_Membrane |
103
PM
|
MassAction | Four1N+GluR1_845_818GluR1_Membrane |
|
|
reaction rate (J): (((Kf * Four1N) * GluR1_845_818) - (Kr * GluR1_Membrane))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 0.0108[molecules.um-2.s-1.uM-2] reverse rate constant (Kr): 0.008[s-1] |
|
Ga_GDP+GbyGaby |
073
PM
|
MassAction | Ga_GDP+GbyGaby |
|
|
reaction rate (J): (((Kf * Ga_GDP) * Gby) - (Kr * Gaby))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 100.0[um2.s-1.molecules-1] reverse rate constant (Kr): 0.0[s-1] |
|
IP3_145IP3_degraded |
r38
IC
|
MassAction | IP3_145IP3_degraded |
|
|
reaction rate (J): ((Kf * IP3_145) - (Kr * IP3_degraded))[uM.s-1]
forward rate constant (Kf): 2.5[s-1] reverse rate constant (Kr): 0.0[s-1] |
|
cAMPAMP |
r12
IC
|
HMMIrreversible | cAMPAMP |
|
|
reaction rate (J): ((Vmax * cAMP) / (Km + cAMP))[uM.s-1]
Km (1/2 max) (Km): 0.3[uM] max reaction rate (Vmax): (Kcat * PDE3)[uM.s-1] user defined (Kcat): 30.0[s-1] |
|
PDE3+IBMXPDE3_IBMX |
r6
IC
|
MassAction | PDE3+IBMXPDE3_IBMX |
|
|
reaction rate (J): (((Kf * PDE3) * IBMX) - (Kr * PDE3_IBMX))[uM.s-1]
forward rate constant (Kf): 8.0[s-1.uM-1] reverse rate constant (Kr): 0.8[s-1] |
|
AMPAR_BulkGluR1 |
100
IC
|
MassAction | AMPAR_BulkGluR1 |
|
|
reaction rate (J): ((Kf * AMPAR_Bulk) - (Kr * GluR1))[uM.s-1]
forward rate constant (Kf): 0.018[s-1] reverse rate constant (Kr): 1.0[s-1] |
|
Da_D5R_GabyDa_D5R+Gby+Ga_GTP |
r0
PM
|
MassAction | Da_D5R_GabyDa_D5R+Gby+Ga_GTP |
|
|
reaction rate (J): ((Kf * Da_D5R_Gaby) - (((Kr * Da_D5R) * Gby) * Ga_GTP))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 20.0[s-1] reverse rate constant (Kr): 0.0[um4.s-1.molecules-2] |
|
Rolipram+PDE4_PKAPDE4_Rolipram |
r11
IC
|
MassAction | Rolipram+PDE4_PKAPDE4_Rolipram |
|
|
reaction rate (J): (((Kf * Rolipram) * PDE4_PKA) - (Kr * PDE4_Rolipram))[uM.s-1]
forward rate constant (Kf): 1.0[s-1.uM-1] reverse rate constant (Kr): 0.019[s-1] |
|
ATPcAMP |
r3
PM
|
HMMIrreversible | ATPcAMP |
|
|
reaction rate (J): ((Vmax * ATP) / (Km + ATP))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] Km (1/2 max) (Km): 20.1149[uM] max reaction rate (Vmax): (Kcat * AC_basal)[molecules.um-2.s-1] user defined (Kcat): 7.0[s-1] |
|
PDE4_ERK_PKAPDE4 |
r55
IC
|
HMMIrreversible | PDE4_ERK_PKAPDE4 |
|
|
reaction rate (J): ((Vmax * PDE4_ERK_PKA) / (Km + PDE4_ERK_PKA))[uM.s-1]
Km (1/2 max) (Km): 8.0[uM] max reaction rate (Vmax): (Kcat * PP1_PDE)[uM.s-1] user defined (Kcat): 1.0[s-1] |
|
ShcShc_Pi |
011
IC
|
HMMIrreversible | ShcShc_Pi |
|
|
reaction rate (J): ((Vmax * Shc) / (Km + Shc))[uM.s-1]
Km (1/2 max) (Km): 0.83331[uM] max reaction rate (Vmax): (0.3 * BDNF_TrkB2_Pi)[uM.s-1] |
|
SoSSoS_Pi |
012
IC
|
HMMIrreversible | SoSSoS_Pi |
|
|
reaction rate (J): ((Vmax * SoS) / (Km + SoS))[uM.s-1]
Km (1/2 max) (Km): 25.641[uM] max reaction rate (Vmax): (10.0 * ERK_active)[uM.s-1] |
|
CaMKII_286_CaMCaMKII_CaM |
097
IC
|
HMMIrreversible | CaMKII_286_CaMCaMKII_CaM |
|
|
reaction rate (J): ((Vmax * CaMKII_286_CaM) / (Km + CaMKII_286_CaM))[uM.s-1]
Km (1/2 max) (Km): 5.1[uM] max reaction rate (Vmax): (Kcat * PP1)[uM.s-1] user defined (Kcat): 0.35[s-1] |
|
Da_D5R+GabyDa_D5R_Gaby |
071
PM
|
MassAction | Da_D5R+GabyDa_D5R_Gaby |
|
|
reaction rate (J): (((Kf * Da_D5R) * Gaby) - (Kr * Da_D5R_Gaby))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 0.6[um2.s-1.molecules-1] reverse rate constant (Kr): 0.001[s-1] |
|
TrkB+BDNF_TrkBBDNF_TrkB2 |
002
PM
|
MassAction | TrkB+BDNF_TrkBBDNF_TrkB2 |
|
|
reaction rate (J): (((Kf * TrkB) * BDNF_TrkB) - (Kr * BDNF_TrkB2))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 1.0[um2.s-1.molecules-1] reverse rate constant (Kr): 0.02[s-1] |
|
PLC+CalciumPLC_Ca |
r35
PM
|
MassAction | PLC+CalciumPLC_Ca |
|
|
reaction rate (J): (((Kf * PLC) * Calcium) - (Kr * PLC_Ca))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 1.0[s-1.uM-1] reverse rate constant (Kr): 1.0[s-1] |
|
Ras_GTPRas_GDP |
023
IC
|
HMMIrreversible | Ras_GTPRas_GDP |
|
|
reaction rate (J): ((Vmax * Ras_GTP) / (Km + Ras_GTP))[uM.s-1]
Km (1/2 max) (Km): 1.0104[uM] max reaction rate (Vmax): (10.0 * Gap)[uM.s-1] |
|
BDNF+TrkBBDNF_TrkB |
001
PM
|
MassAction | BDNF+TrkBBDNF_TrkB |
|
|
reaction rate (J): (((Kf * BDNF) * TrkB) - (Kr * BDNF_TrkB))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 1.0[s-1.uM-1] reverse rate constant (Kr): 0.05[s-1] |
|
PLC_GqGq_GDP+PLC |
r36
PM
|
MassAction | PLC_GqGq_GDP+PLC |
|
|
reaction rate (J): ((Kf * PLC_Gq) - ((Kr * Gq_GDP) * PLC))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 0.094[s-1] reverse rate constant (Kr): 0.0[um2.s-1.molecules-1] |
|
R2C2_cAMP2+cAMPR2C2_cAMP3 |
084
IC
|
MassAction | R2C2_cAMP2+cAMPR2C2_cAMP3 |
|
|
reaction rate (J): (((Kf * R2C2_cAMP2) * cAMP) - (Kr * R2C2_cAMP3))[uM.s-1]
forward rate constant (Kf): 75.0[s-1.uM-1] reverse rate constant (Kr): 110.0[s-1] |
|
PDE1+CaM_Ca4PDE1_CaM_Ca4 |
098
IC
|
MassAction | PDE1+CaM_Ca4PDE1_CaM_Ca4 |
|
|
reaction rate (J): (((Kf * PDE1) * CaM_Ca4) - (Kr * PDE1_CaM_Ca4))[uM.s-1]
forward rate constant (Kf): 0.1[s-1.uM-1] reverse rate constant (Kr): 1.0[s-1] |
|
Da+D1LRDa_D1LR |
r26
PM
|
MassAction | Da+D1LRDa_D1LR |
|
|
reaction rate (J): (((Kf * Da) * D1LR) - (Kr * Da_D1LR))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 1.11[s-1.uM-1] reverse rate constant (Kr): 10.0[s-1] |
|
cAMPAMP |
081
IC
|
HMMIrreversible | cAMPAMP |
|
|
reaction rate (J): ((Vmax * cAMP) / (Km + cAMP))[uM.s-1]
Km (1/2 max) (Km): 39.683[uM] max reaction rate (Vmax): (Kcat * PDE1_CaM_Ca4)[uM.s-1] user defined (Kcat): 10.0[s-1] |
|
GluR1_Membrane_dephosphorylated1GluR1+Four1N |
104
PM
|
MassAction | GluR1_Membrane_dephosphorylated1GluR1+Four1N |
|
|
reaction rate (J): ((Kf * GluR1_Membrane_dephosphorylated1) - ((Kr * GluR1) * Four1N))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 8.0E-4[s-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-2] |
|
cAMPAMP |
077
IC
|
HMMIrreversible | cAMPAMP |
|
|
reaction rate (J): ((Vmax * cAMP) / (Km + cAMP))[uM.s-1]
Km (1/2 max) (Km): 1.8[uM] max reaction rate (Vmax): (Kcat * PDE4)[uM.s-1] user defined (Kcat): 10.0[s-1] |
|
MEK_SerMEK |
032
IC
|
HMMIrreversible | MEK_SerMEK |
|
|
reaction rate (J): ((Vmax * MEK_Ser) / (Km + MEK_Ser))[uM.s-1]
Km (1/2 max) (Km): 15.657[uM] max reaction rate (Vmax): (Kcat * PP2A)[uM.s-1] user defined (Kcat): 6.0[s-1] |
|
SoS_Pi+Grb2SoS_Pi_Grb2 |
008
IC
|
MassAction | SoS_Pi+Grb2SoS_Pi_Grb2 |
|
|
reaction rate (J): (((Kf * SoS_Pi) * Grb2) - (Kr * SoS_Pi_Grb2))[uM.s-1]
forward rate constant (Kf): 0.025[s-1.uM-1] reverse rate constant (Kr): 0.0168[s-1] |
|
Shc_PiShc |
006
IC
|
MassAction | Shc_PiShc |
|
|
reaction rate (J): ((Kf * Shc_Pi) - (Kr * Shc))[uM.s-1]
forward rate constant (Kf): 1.0E-4[s-1] reverse rate constant (Kr): 0.0[s-1] |
|
Da_D1LR+GqbyDa_D1LR_Gqby |
r27
PM
|
MassAction | Da_D1LR+GqbyDa_D1LR_Gqby |
|
|
reaction rate (J): (((Kf * Da_D1LR) * Gqby) - (Kr * Da_D1LR_Gqby))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 0.6[um2.s-1.molecules-1] reverse rate constant (Kr): 0.001[s-1] |
|
PDE4_PKAPDE4 |
046
IC
|
HMMIrreversible | PDE4_PKAPDE4 |
|
|
reaction rate (J): ((Vmax * PDE4_PKA) / (Km + PDE4_PKA))[uM.s-1]
Km (1/2 max) (Km): 8.0[uM] max reaction rate (Vmax): (Kcat * PP1_PDE)[uM.s-1] user defined (Kcat): 5.0[s-1] |
|
I1I1_Pi |
060
IC
|
HMMIrreversible | I1I1_Pi |
|
|
reaction rate (J): ((Vmax * I1) / (Km + I1))[uM.s-1]
Km (1/2 max) (Km): 7.5[uM] max reaction rate (Vmax): (Kcat * PKA_active)[uM.s-1] user defined (Kcat): 6.0[s-1] |
|
Ras_GDPRas_GTP |
018
IC
|
HMMIrreversible | Ras_GDPRas_GTP |
|
|
reaction rate (J): ((Vmax * Ras_GDP) / (Km + Ras_GDP))[uM.s-1]
Km (1/2 max) (Km): 0.50505[uM] max reaction rate (Vmax): (0.2 * Shc_Pi_SoS_Grb2)[uM.s-1] |
|
cAMPAMP |
r48
IC
|
HMMIrreversible | cAMPAMP |
|
|
reaction rate (J): ((Vmax * cAMP) / (Km + cAMP))[uM.s-1]
Km (1/2 max) (Km): 1.8[uM] max reaction rate (Vmax): (Kcat * PDE4_ERK)[uM.s-1] user defined (Kcat): 0.01[s-1] |
|
PDE4PDE4_PKA |
045
IC
|
HMMIrreversible | PDE4PDE4_PKA |
|
|
reaction rate (J): ((Vmax * PDE4) / (Km + PDE4))[uM.s-1]
Km (1/2 max) (Km): 7.5[uM] max reaction rate (Vmax): (Kcat * PKA_active)[uM.s-1] user defined (Kcat): 3.0[s-1] |
|
Ga_GTP+AC5AC5_Ga |
075
PM
|
MassAction | Ga_GTP+AC5AC5_Ga |
|
|
reaction rate (J): (((Kf * Ga_GTP) * AC5) - (Kr * AC5_Ga))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 38.5[um2.s-1.molecules-1] reverse rate constant (Kr): 50.0[s-1] |
|
SoS_PiSoS |
009
IC
|
MassAction | SoS_PiSoS |
|
|
reaction rate (J): ((Kf * SoS_Pi) - (Kr * SoS))[uM.s-1]
forward rate constant (Kf): 0.001[s-1] reverse rate constant (Kr): 0.0[s-1] |
|
cAMPAMP |
r50
IC
|
HMMIrreversible | cAMPAMP |
|
|
reaction rate (J): ((Vmax * cAMP) / (Km + cAMP))[uM.s-1]
Km (1/2 max) (Km): 30.0[uM] max reaction rate (Vmax): (Kcat * PDE2)[uM.s-1] user defined (Kcat): 12.0[s-1] |
|
BDNF_TrkB2_PiInt_TrkB2 |
004
PM
|
MassAction | BDNF_TrkB2_PiInt_TrkB2 |
|
|
reaction rate (J): ((Kf * BDNF_TrkB2_Pi) - (Kr * Int_TrkB2))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 1.0E-4[molecules.um-2.s-1.uM-1] reverse rate constant (Kr): 0.0[s-1] |
|
GluR1_845_818GluR1_845 |
r56
IC
|
HMMIrreversible | GluR1_845_818GluR1_845 |
|
|
reaction rate (J): ((Vmax * GluR1_845_818) / (Km + GluR1_845_818))[uM.s-1]
Km (1/2 max) (Km): 0.97145[uM] max reaction rate (Vmax): (Kcat * PP1)[uM.s-1] user defined (Kcat): 0.17[s-1] |
|
PLC_Gq+CalciumPLC_Ca_Gq |
r37
PM
|
MassAction | PLC_Gq+CalciumPLC_Ca_Gq |
|
|
reaction rate (J): (((Kf * PLC_Gq) * Calcium) - (Kr * PLC_Ca_Gq))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 30.0[s-1.uM-1] reverse rate constant (Kr): 1.0[s-1] |
|
PIP2DAG+IP3_145 |
r32
PM
|
HMMIrreversible | PIP2DAG+IP3_145 |
|
|
reaction rate (J): ((Vmax * PIP2) / (Km + PIP2))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] Km (1/2 max) (Km): 5.0[molecules.um-2] max reaction rate (Vmax): (Kcat * PLC_Ca_Gq)[molecules.um-2.s-1] user defined (Kcat): 48.0[s-1] |
|
SoS_Grb2+Shc_PiShc_Pi_SoS_Grb2 |
007
IC
|
MassAction | SoS_Grb2+Shc_PiShc_Pi_SoS_Grb2 |
|
|
reaction rate (J): (((Kf * SoS_Grb2) * Shc_Pi) - (Kr * Shc_Pi_SoS_Grb2))[uM.s-1]
forward rate constant (Kf): 0.5[s-1.uM-1] reverse rate constant (Kr): 0.1[s-1] |
|
GluR1GluR1_845 |
106
IC
|
HMMIrreversible | GluR1GluR1_845 |
|
|
reaction rate (J): ((Vmax * GluR1) / (Km + GluR1))[uM.s-1]
Km (1/2 max) (Km): 7.5002[uM] max reaction rate (Vmax): (Kcat * PKA_active)[uM.s-1] user defined (Kcat): 6.0[s-1] |
|
Gq_GDP+G_byGqby |
r29
PM
|
MassAction | Gq_GDP+G_byGqby |
|
|
reaction rate (J): (((Kf * Gq_GDP) * G_by) - (Kr * Gqby))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 100.0[um2.s-1.molecules-1] reverse rate constant (Kr): 0.0[s-1] |
|
D1R_Gaby+DaDa_D1R_Gaby |
067
PM
|
MassAction | D1R_Gaby+DaDa_D1R_Gaby |
|
|
reaction rate (J): (((Kf * D1R_Gaby) * Da) - (Kr * Da_D1R_Gaby))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 3.33[s-1.uM-1] reverse rate constant (Kr): 10.0[s-1] |
|
PKA_active+PKA_InhibitorPKA_inhibited |
088
IC
|
MassAction | PKA_active+PKA_InhibitorPKA_inhibited |
|
|
reaction rate (J): (((Kf * PKA_active) * PKA_Inhibitor) - (Kr * PKA_inhibited))[uM.s-1]
forward rate constant (Kf): 60.0[s-1.uM-1] reverse rate constant (Kr): 1.0[s-1] |
|
PDE4_ERK+IBMXPDE4_IBMX |
r24
IC
|
MassAction | PDE4_ERK+IBMXPDE4_IBMX |
|
|
reaction rate (J): (((Kf * PDE4_ERK) * IBMX) - (Kr * PDE4_IBMX))[uM.s-1]
forward rate constant (Kf): 8.0[s-1.uM-1] reverse rate constant (Kr): 0.8[s-1] |
|
PIP2IP3_145+DAG |
r31
PM
|
HMMIrreversible | PIP2IP3_145+DAG |
|
|
reaction rate (J): ((Vmax * PIP2) / (Km + PIP2))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] Km (1/2 max) (Km): 5.0[molecules.um-2] max reaction rate (Vmax): (Kcat * PLC_Gq)[molecules.um-2.s-1] user defined (Kcat): 75.0[s-1] |
|
PDE4_PKA+IBMXPDE4_IBMX |
r22
IC
|
MassAction | PDE4_PKA+IBMXPDE4_IBMX |
|
|
reaction rate (J): (((Kf * PDE4_PKA) * IBMX) - (Kr * PDE4_IBMX))[uM.s-1]
forward rate constant (Kf): 8.0[s-1.uM-1] reverse rate constant (Kr): 0.8[s-1] |
|
PLC+Gq_GTPPLC_Gq |
r34
PM
|
MassAction | PLC+Gq_GTPPLC_Gq |
|
|
reaction rate (J): (((Kf * PLC) * Gq_GTP) - (Kr * PLC_Gq))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 0.25[um2.s-1.molecules-1] reverse rate constant (Kr): 0.003[s-1] |
|
Grb2+SoSSoS_Grb2 |
010
IC
|
MassAction | Grb2+SoSSoS_Grb2 |
|
|
reaction rate (J): (((Kf * Grb2) * SoS) - (Kr * SoS_Grb2))[uM.s-1]
forward rate constant (Kf): 0.025[s-1.uM-1] reverse rate constant (Kr): 0.0168[s-1] |
|
DARPP32_Pi+PP1DARPP32_Pi_PP1 |
r18
IC
|
MassAction | DARPP32_Pi+PP1DARPP32_Pi_PP1 |
|
|
reaction rate (J): (((Kf * DARPP32_Pi) * PP1) - (Kr * DARPP32_Pi_PP1))[uM.s-1]
forward rate constant (Kf): 100.0[s-1.uM-1] reverse rate constant (Kr): 0.2[s-1] |
|
ATPcAMP |
r1
PM
|
HMMIrreversible | ATPcAMP |
|
|
reaction rate (J): ((Vmax * ATP) / (Km + ATP))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] Km (1/2 max) (Km): 315.0[uM] max reaction rate (Vmax): (Kcat * AC5_Ga)[molecules.um-2.s-1] user defined (Kcat): 8.5[s-1] |
|
ERK_activeERK_Tyr |
r49
IC
|
HMMIrreversible | ERK_activeERK_Tyr |
|
|
reaction rate (J): ((Vmax * ERK_active) / (Km + ERK_active))[uM.s-1]
Km (1/2 max) (Km): 0.77[uM] max reaction rate (Vmax): (Kcat * PP2A)[uM.s-1] user defined (Kcat): 0.636[s-1] |
|
GluR1_MembraneGluR1_degraded |
105
PM
|
MassAction | GluR1_MembraneGluR1_degraded |
|
|
reaction rate (J): ((Kf * GluR1_Membrane) - (Kr * GluR1_degraded))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 3.6E-5[s-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-1] |
|
MEKMEK_Ser |
034
IC
|
HMMIrreversible | MEKMEK_Ser |
|
|
reaction rate (J): ((Vmax * MEK) / (Km + MEK))[uM.s-1]
Km (1/2 max) (Km): 0.15909[uM] max reaction rate (Vmax): (Kcat * BRaf_Pi)[uM.s-1] user defined (Kcat): 0.18[s-1] |
|
BRaf_PiBRaf |
063
IC
|
HMMIrreversible | BRaf_PiBRaf |
|
|
reaction rate (J): ((Vmax * BRaf_Pi) / (Km + BRaf_Pi))[uM.s-1]
Km (1/2 max) (Km): 15.657[uM] max reaction rate (Vmax): (Kcat * PP2A)[uM.s-1] user defined (Kcat): 6.0[s-1] |
|
DARPP32_Pi_PP1PP1+DARPP32 |
r47
IC
|
MassAction | DARPP32_Pi_PP1PP1+DARPP32 |
|
|
reaction rate (J): ((Kf * DARPP32_Pi_PP1) - ((Kr * PP1) * DARPP32))[uM.s-1]
forward rate constant (Kf): 10.0[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1] |
|
CaMKII_CaMCaMKII_286_CaM |
095
IC
|
HMMIrreversible | CaMKII_CaMCaMKII_286_CaM |
|
|
reaction rate (J): ((Vmax * CaMKII_CaM) / (Km + CaMKII_CaM))[uM.s-1]
Km (1/2 max) (Km): 113.6[uM] max reaction rate (Vmax): (Kcat * CaMKII)[uM.s-1] user defined (Kcat): 0.5[s-1] |
|
Gaby+D1RD1R_Gaby |
065
PM
|
MassAction | Gaby+D1RD1R_Gaby |
|
|
reaction rate (J): (((Kf * Gaby) * D1R) - (Kr * D1R_Gaby))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 0.06[um2.s-1.molecules-1] reverse rate constant (Kr): 3.0E-4[s-1] |
|
PDE2+IBMXPDE2_IBMX |
r51
IC
|
MassAction | PDE2+IBMXPDE2_IBMX |
|
|
reaction rate (J): (((Kf * PDE2) * IBMX) - (Kr * PDE2_IBMX))[uM.s-1]
forward rate constant (Kf): 8.0[s-1.uM-1] reverse rate constant (Kr): 0.8[s-1] |
|
MEK_SerMEK_active |
029
IC
|
HMMIrreversible | MEK_SerMEK_active |
|
|
reaction rate (J): ((Vmax * MEK_Ser) / (Km + MEK_Ser))[uM.s-1]
Km (1/2 max) (Km): 0.15909[uM] max reaction rate (Vmax): (0.3 * Ras_Raf_active)[uM.s-1] |
|
CaM+CalciumCaM_Ca2 |
089
IC
|
MassAction | CaM+CalciumCaM_Ca2 |
|
|
reaction rate (J): (((Kf * CaM) * pow(Calcium,2.0)) - (Kr * CaM_Ca2))[uM.s-1]
forward rate constant (Kf): 72.0[s-1.uM-2] reverse rate constant (Kr): 72.0[s-1] |
|
Calcium_ERCalcium |
r43
ER_Membrane
|
MassAction | Calcium_ERCalcium |
|
|
reaction rate (J): ((Kf * Calcium_ER) - (Kr * Calcium))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 5.34E-4[molecules.um-2.s-1.uM-1] reverse rate constant (Kr): 5.34E-4[molecules.um-2.s-1.uM-1] |
|
I1_Pi+PP1I1_Pi_PP1 |
r53
IC
|
MassAction | I1_Pi+PP1I1_Pi_PP1 |
|
|
reaction rate (J): (((Kf * I1_Pi) * PP1) - (Kr * I1_Pi_PP1))[uM.s-1]
forward rate constant (Kf): 150.0[s-1.uM-1] reverse rate constant (Kr): 0.1[s-1] |
|
PIP2DAG+IP3_145 |
r33
PM
|
HMMIrreversible | PIP2DAG+IP3_145 |
|
|
reaction rate (J): ((Vmax * PIP2) / (Km + PIP2))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] Km (1/2 max) (Km): 19.8413[molecules.um-2] max reaction rate (Vmax): (Kcat * PLC_Ca)[molecules.um-2.s-1] user defined (Kcat): 10.0[s-1] |
|
R2C2+cAMPR2C2_cAMP |
082
IC
|
MassAction | R2C2+cAMPR2C2_cAMP |
|
|
reaction rate (J): (((Kf * R2C2) * cAMP) - (Kr * R2C2_cAMP))[uM.s-1]
forward rate constant (Kf): 54.0[s-1.uM-1] reverse rate constant (Kr): 33.0[s-1] |
|
STEPSTEP_PKA |
040
IC
|
HMMIrreversible | STEPSTEP_PKA |
|
|
reaction rate (J): ((Vmax * STEP) / (Km + STEP))[uM.s-1]
Km (1/2 max) (Km): 25.641[uM] max reaction rate (Vmax): (Kcat * PKA_active)[uM.s-1] user defined (Kcat): 1.0[s-1] |
|
PDE4+RolipramPDE4_Rolipram |
r9
IC
|
MassAction | PDE4+RolipramPDE4_Rolipram |
|
|
reaction rate (J): (((Kf * PDE4) * Rolipram) - (Kr * PDE4_Rolipram))[uM.s-1]
forward rate constant (Kf): 1.0[s-1.uM-1] reverse rate constant (Kr): 0.019[s-1] |
|
PDE4_ERKPDE4_ERK_PKA |
052
IC
|
HMMIrreversible | PDE4_ERKPDE4_ERK_PKA |
|
|
reaction rate (J): ((Vmax * PDE4_ERK) / (Km + PDE4_ERK))[uM.s-1]
Km (1/2 max) (Km): 7.5[uM] max reaction rate (Vmax): (Kcat * PKA_active)[uM.s-1] user defined (Kcat): 0.1[s-1] |
|
Da+D5R_GabyDa_D5R_Gaby |
070
PM
|
MassAction | Da+D5R_GabyDa_D5R_Gaby |
|
|
reaction rate (J): (((Kf * Da) * D5R_Gaby) - (Kr * Da_D5R_Gaby))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 3.33[s-1.uM-1] reverse rate constant (Kr): 1.0[s-1] |
|
Gq_GTPGq_GDP |
r30
PM
|
MassAction | Gq_GTPGq_GDP |
|
|
reaction rate (J): ((Kf * Gq_GTP) - (Kr * Gq_GDP))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 10.0[s-1] reverse rate constant (Kr): 0.0[s-1] |
|
Gaby+D5RD5R_Gaby |
069
PM
|
MassAction | Gaby+D5RD5R_Gaby |
|
|
reaction rate (J): (((Kf * Gaby) * D5R) - (Kr * D5R_Gaby))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 0.06[um2.s-1.molecules-1] reverse rate constant (Kr): 3.0E-4[s-1] |
|
cAMPAMP |
079
IC
|
HMMIrreversible | cAMPAMP |
|
|
reaction rate (J): ((Vmax * cAMP) / (Km + cAMP))[uM.s-1]
Km (1/2 max) (Km): 1.8[uM] max reaction rate (Vmax): (Kcat * PDE4_PKA)[uM.s-1] user defined (Kcat): 27.0[s-1] |
|
ATPcAMP |
r4
PM
|
HMMIrreversible | ATPcAMP |
|
|
reaction rate (J): ((Vmax * ATP) / (Km + ATP))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] Km (1/2 max) (Km): 1030.0[uM] max reaction rate (Vmax): (Kcat * AC5)[molecules.um-2.s-1] user defined (Kcat): 0.2[s-1] |
|
ERK_TyrERK_active |
037
IC
|
HMMIrreversible | ERK_TyrERK_active |
|
|
reaction rate (J): ((Vmax * ERK_Tyr) / (Km + ERK_Tyr))[uM.s-1]
Km (1/2 max) (Km): 0.046296[uM] max reaction rate (Vmax): (Kcat * MEK_active)[uM.s-1] user defined (Kcat): 0.15[s-1] |
|
Ras_GTP+RafRas_Raf_active |
016
IC
|
MassAction | Ras_GTP+RafRas_Raf_active |
|
|
reaction rate (J): (((Kf * Ras_GTP) * Raf) - (Kr * Ras_Raf_active))[uM.s-1]
forward rate constant (Kf): 6.0[s-1.uM-1] reverse rate constant (Kr): 1.0[s-1] |
|
Ga_GTPGa_GDP |
074
PM
|
MassAction | Ga_GTPGa_GDP |
|
|
reaction rate (J): ((Kf * Ga_GTP) - (Kr * Ga_GDP))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 10.0[s-1] reverse rate constant (Kr): 0.0[s-1] |
|
CaMKII_286+CaM_Ca4CaMKII_286_CaM |
093
IC
|
MassAction | CaMKII_286+CaM_Ca4CaMKII_286_CaM |
|
|
reaction rate (J): (((Kf * CaMKII_286) * CaM_Ca4) - (Kr * CaMKII_286_CaM))[uM.s-1]
forward rate constant (Kf): 1000.0[s-1.uM-1] reverse rate constant (Kr): 0.1[s-1] |
|
I1_Pi_PP1PP1+I1 |
r54
IC
|
MassAction | I1_Pi_PP1PP1+I1 |
|
|
reaction rate (J): ((Kf * I1_Pi_PP1) - ((Kr * PP1) * I1))[uM.s-1]
forward rate constant (Kf): 1.0[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1] |
|
cAMPAMP |
080
IC
|
HMMIrreversible | cAMPAMP |
|
|
reaction rate (J): ((Vmax * cAMP) / (Km + cAMP))[uM.s-1]
Km (1/2 max) (Km): 39.7[uM] max reaction rate (Vmax): (Kcat * PDE1)[uM.s-1] user defined (Kcat): 1.667[s-1] |
|
Da_D1R_GabyGby+Ga_GTP+Da_D1R |
072
PM
|
MassAction | Da_D1R_GabyGby+Ga_GTP+Da_D1R |
|
|
reaction rate (J): ((Kf * Da_D1R_Gaby) - (((Kr * Gby) * Ga_GTP) * Da_D1R))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 20.0[s-1] reverse rate constant (Kr): 0.0[um4.s-1.molecules-2] |
|
PDE4_PKAPDE4_ERK_PKA |
049
IC
|
HMMIrreversible | PDE4_PKAPDE4_ERK_PKA |
|
|
reaction rate (J): ((Vmax * PDE4_PKA) / (Km + PDE4_PKA))[uM.s-1]
Km (1/2 max) (Km): 25.641[uM] max reaction rate (Vmax): (Kcat * ERK_active)[uM.s-1] user defined (Kcat): 0.1[s-1] |
|
MEK+U0126MEK_inhibited |
r16
IC
|
MassAction | MEK+U0126MEK_inhibited |
|
|
reaction rate (J): (((Kf * MEK) * U0126) - (Kr * MEK_inhibited))[uM.s-1]
forward rate constant (Kf): 1.0[s-1.uM-1] reverse rate constant (Kr): 0.03[s-1] |
|
IP3_145IP3_14 |
r39
IC
|
HMMIrreversible | IP3_145IP3_14 |
|
|
reaction rate (J): ((Vmax * IP3_145) / (Km + IP3_145))[uM.s-1]
Km (1/2 max) (Km): 3.0[uM] max reaction rate (Vmax): (Kcat * IP3_5pase1)[uM.s-1] user defined (Kcat): 1.1[s-1] |
|
D5R+DaDa_D5R |
068
PM
|
MassAction | D5R+DaDa_D5R |
|
|
reaction rate (J): (((Kf * D5R) * Da) - (Kr * Da_D5R))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 1.11[s-1.uM-1] reverse rate constant (Kr): 1.0[s-1] |
|
PDE4PDE4_ERK |
047
IC
|
HMMIrreversible | PDE4PDE4_ERK |
|
|
reaction rate (J): ((Vmax * PDE4) / (Km + PDE4))[uM.s-1]
Km (1/2 max) (Km): 0.47[uM] max reaction rate (Vmax): (Kcat * ERK_active)[uM.s-1] user defined (Kcat): 10.0[s-1] |
|
PDE1_CaM_Ca4+IBMXPDE1_IBMX |
r5
IC
|
MassAction | PDE1_CaM_Ca4+IBMXPDE1_IBMX |
|
|
reaction rate (J): (((Kf * PDE1_CaM_Ca4) * IBMX) - (Kr * PDE1_IBMX))[uM.s-1]
forward rate constant (Kf): 8.0[s-1.uM-1] reverse rate constant (Kr): 0.8[s-1] |
|
ERK_TyrERK |
044
IC
|
HMMIrreversible | ERK_TyrERK |
|
|
reaction rate (J): ((Vmax * ERK_Tyr) / (Km + ERK_Tyr))[uM.s-1]
Km (1/2 max) (Km): 9.0[uM] max reaction rate (Vmax): (Kcat * STEP_PKA)[uM.s-1] user defined (Kcat): 0.1[s-1] |
|
cAMP+R2C2_cAMPR2C2_cAMP2 |
083
IC
|
MassAction | cAMP+R2C2_cAMPR2C2_cAMP2 |
|
|
reaction rate (J): (((Kf * cAMP) * R2C2_cAMP) - (Kr * R2C2_cAMP2))[uM.s-1]
forward rate constant (Kf): 54.0[s-1.uM-1] reverse rate constant (Kr): 33.0[s-1] |
|
CaM_Ca2+CalciumCaM_Ca3 |
090
IC
|
MassAction | CaM_Ca2+CalciumCaM_Ca3 |
|
|
reaction rate (J): (((Kf * CaM_Ca2) * Calcium) - (Kr * CaM_Ca3))[uM.s-1]
forward rate constant (Kf): 3.6[s-1.uM-1] reverse rate constant (Kr): 10.0[s-1] |
|
Calcium_ERCalcium |
r45
ER_Membrane
|
GeneralKinetics | Calcium_ERCalcium |
|
|
reaction rate (J): (J0 * Kc * (Calcium_ER - Calcium) * IP3R_open / (Kc + Calcium))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] user defined (J0): 0.8[uM-1.s-1] user defined (Kc): 4.69[uM] |
|
MEKMEK_Ser |
028
IC
|
HMMIrreversible | MEKMEK_Ser |
|
|
reaction rate (J): ((Vmax * MEK) / (Km + MEK))[uM.s-1]
Km (1/2 max) (Km): 0.15909[uM] max reaction rate (Vmax): (0.3 * Ras_Raf_active)[uM.s-1] |
|
CaMKIICaMKII_286 |
094
IC
|
MassAction | CaMKIICaMKII_286 |
|
|
reaction rate (J): ((Kf * CaMKII) - (Kr * CaMKII_286))[uM.s-1]
forward rate constant (Kf): 0.003[s-1] reverse rate constant (Kr): 0.0[s-1] |
|
BDNF_TrkB2BDNF_TrkB2_Pi |
003
PM
|
MassAction | BDNF_TrkB2BDNF_TrkB2_Pi |
|
|
reaction rate (J): ((Kf * BDNF_TrkB2) - (Kr * BDNF_TrkB2_Pi))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 0.02[s-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-1] |
|
MEK_SerMEK_active |
035
IC
|
HMMIrreversible | MEK_SerMEK_active |
|
|
reaction rate (J): ((Vmax * MEK_Ser) / (Km + MEK_Ser))[uM.s-1]
Km (1/2 max) (Km): 0.15909[uM] max reaction rate (Vmax): (Kcat * BRaf_Pi)[uM.s-1] user defined (Kcat): 0.18[s-1] |
|
MEK_activeMEK_Ser |
033
IC
|
HMMIrreversible | MEK_activeMEK_Ser |
|
|
reaction rate (J): ((Vmax * MEK_active) / (Km + MEK_active))[uM.s-1]
Km (1/2 max) (Km): 15.657[uM] max reaction rate (Vmax): (Kcat * PP2A)[uM.s-1] user defined (Kcat): 6.0[s-1] |
|
MEK_Ser+U0126MEK_inhibited |
r14
IC
|
MassAction | MEK_Ser+U0126MEK_inhibited |
|
|
reaction rate (J): (((Kf * MEK_Ser) * U0126) - (Kr * MEK_inhibited))[uM.s-1]
forward rate constant (Kf): 1.0[s-1.uM-1] reverse rate constant (Kr): 0.03[s-1] |
|
MEK_active+U0126MEK_inhibited |
r15
IC
|
MassAction | MEK_active+U0126MEK_inhibited |
|
|
reaction rate (J): (((Kf * MEK_active) * U0126) - (Kr * MEK_inhibited))[uM.s-1]
forward rate constant (Kf): 1.0[s-1.uM-1] reverse rate constant (Kr): 0.03[s-1] |
|
GluR1_845GluR1 |
108
IC
|
HMMIrreversible | GluR1_845GluR1 |
|
|
reaction rate (J): ((Vmax * GluR1_845) / (Km + GluR1_845))[uM.s-1]
Km (1/2 max) (Km): 0.97145[uM] max reaction rate (Vmax): (Kcat * PP1)[uM.s-1] user defined (Kcat): 0.17[s-1] |
|
GluR1_845GluR1_845_818 |
r57
IC
|
HMMIrreversible | GluR1_845GluR1_845_818 |
|
|
reaction rate (J): ((Vmax * GluR1_845) / (Km + GluR1_845))[uM.s-1]
Km (1/2 max) (Km): 33.0[uM] max reaction rate (Vmax): (Kcat * PKC_active)[uM.s-1] user defined (Kcat): 4.0[s-1] |
|
Rolipram+PDE4_ERKPDE4_Rolipram |
r8
IC
|
MassAction | Rolipram+PDE4_ERKPDE4_Rolipram |
|
|
reaction rate (J): (((Kf * Rolipram) * PDE4_ERK) - (Kr * PDE4_Rolipram))[uM.s-1]
forward rate constant (Kf): 1.0[s-1.uM-1] reverse rate constant (Kr): 0.019[s-1] |
|
PDE4_ERK_PKA+IBMXPDE4_IBMX |
r23
IC
|
MassAction | PDE4_ERK_PKA+IBMXPDE4_IBMX |
|
|
reaction rate (J): (((Kf * PDE4_ERK_PKA) * IBMX) - (Kr * PDE4_IBMX))[uM.s-1]
forward rate constant (Kf): 8.0[s-1.uM-1] reverse rate constant (Kr): 0.8[s-1] |
|
Gqby+D1LRD1LR_Gqby |
r13
PM
|
MassAction | Gqby+D1LRD1LR_Gqby |
|
|
reaction rate (J): (((Kf * Gqby) * D1LR) - (Kr * D1LR_Gqby))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 0.06[um2.s-1.molecules-1] reverse rate constant (Kr): 3.0E-4[s-1] |
|
I1_PiI1 |
061
IC
|
HMMIrreversible | I1_PiI1 |
|
|
reaction rate (J): ((Vmax * I1_Pi) / (Km + I1_Pi))[uM.s-1]
Km (1/2 max) (Km): 16.0[uM] max reaction rate (Vmax): (Kcat * PP2A_DI)[uM.s-1] user defined (Kcat): 2.0[s-1] |
|
Gaby+Da_D1RDa_D1R_Gaby |
066
PM
|
MassAction | Gaby+Da_D1RDa_D1R_Gaby |
|
|
reaction rate (J): (((Kf * Gaby) * Da_D1R) - (Kr * Da_D1R_Gaby))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 0.6[um2.s-1.molecules-1] reverse rate constant (Kr): 0.001[s-1] |
|
Ras_GTPRas_GDP |
014
IC
|
MassAction | Ras_GTPRas_GDP |
|
|
reaction rate (J): ((Kf * Ras_GTP) - (Kr * Ras_GDP))[uM.s-1]
forward rate constant (Kf): 1.0E-4[s-1] reverse rate constant (Kr): 0.0[s-1] |
|
GluR1_MembraneGluR1_Membrane_dephosphorylated1 |
r17
PM
|
HMMIrreversible | GluR1_MembraneGluR1_Membrane_dephosphorylated1 |
|
|
reaction rate (J): ((Vmax * GluR1_Membrane) / (Km + GluR1_Membrane))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] Km (1/2 max) (Km): 0.97145[molecules.um-2] max reaction rate (Vmax): (Kcat * PP1)[molecules.um-2.s-1] user defined (Kcat): 0.17[molecules.um-2.uM-1.s-1] |
|
BRafBRaf_Pi |
062
IC
|
HMMIrreversible | BRafBRaf_Pi |
|
|
reaction rate (J): ((Vmax * BRaf) / (Km + BRaf))[uM.s-1]
Km (1/2 max) (Km): 7.5[uM] max reaction rate (Vmax): (Kcat * PKA_active)[uM.s-1] user defined (Kcat): 3.0[s-1] |
|
SERCA+CalciumSERCA_active |
r42
ER_Membrane
|
GeneralKinetics | SERCA+CalciumSERCA_active |
|
|
reaction rate (J): (SERCA / (1.0 + (2.5 / (Calcium * Calcium)) + (0.25 / Calcium)))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] |
|
PDE1_CaM_Ca4PDE1 |
099
IC
|
MassAction | PDE1_CaM_Ca4PDE1 |
|
|
reaction rate (J): ((Kf * PDE1_CaM_Ca4) - (Kr * PDE1))[uM.s-1]
forward rate constant (Kf): 0.1[s-1] reverse rate constant (Kr): 0.0[s-1] |
|
ATPcAMP |
r25
PM
|
HMMIrreversible | ATPcAMP |
|
|
reaction rate (J): ((Vmax * ATP) / (Km + ATP))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] Km (1/2 max) (Km): 315.0[uM] max reaction rate (Vmax): (Kcat * AC5_Fsk)[molecules.um-2.s-1] user defined (Kcat): 8.5[s-1] |
|
R2C2_cAMP4PKA_active+R2C_cAMP4 |
086
IC
|
MassAction | R2C2_cAMP4PKA_active+R2C_cAMP4 |
|
|
reaction rate (J): ((Kf * R2C2_cAMP4) - ((Kr * PKA_active) * R2C_cAMP4))[uM.s-1]
forward rate constant (Kf): 60.0[s-1] reverse rate constant (Kr): 18.0[s-1.uM-1] |
|
IP3R+IP3_145IP3R_open |
r41
ER_Membrane
|
MassAction | IP3R+IP3_145IP3R_open |
|
|
reaction rate (J): (((Kf * IP3R) * pow(IP3_145,3.0)) - (Kr * IP3R_open))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 1.0[s-1.uM-3] reverse rate constant (Kr): 2.7[s-1] |
|
PDE4_ERKPDE4 |
048
IC
|
HMMIrreversible | PDE4_ERKPDE4 |
|
|
reaction rate (J): ((Vmax * PDE4_ERK) / (Km + PDE4_ERK))[uM.s-1]
Km (1/2 max) (Km): 8.0[uM] max reaction rate (Vmax): (Kcat * PP1_PDE)[uM.s-1] user defined (Kcat): 5.0[s-1] |
|
ERK_TyrERK |
043
IC
|
HMMIrreversible | ERK_TyrERK |
|
|
reaction rate (J): ((Vmax * ERK_Tyr) / (Km + ERK_Tyr))[uM.s-1]
Km (1/2 max) (Km): 0.46[uM] max reaction rate (Vmax): (Kcat * STEP)[uM.s-1] user defined (Kcat): 1.06[s-1] |
|
R2C2_cAMP3+cAMPR2C2_cAMP4 |
085
IC
|
MassAction | R2C2_cAMP3+cAMPR2C2_cAMP4 |
|
|
reaction rate (J): (((Kf * R2C2_cAMP3) * cAMP) - (Kr * R2C2_cAMP4))[uM.s-1]
forward rate constant (Kf): 75.0[s-1.uM-1] reverse rate constant (Kr): 32.5[s-1] |
|
CaM_Ca4+CaMKIICaMKII_CaM |
092
IC
|
MassAction | CaM_Ca4+CaMKIICaMKII_CaM |
|
|
reaction rate (J): (((Kf * CaM_Ca4) * CaMKII) - (Kr * CaMKII_CaM))[uM.s-1]
forward rate constant (Kf): 50.0[s-1.uM-1] reverse rate constant (Kr): 5.0[s-1] |
|
STEP_PKASTEP |
041
IC
|
HMMIrreversible | STEP_PKASTEP |
|
|
reaction rate (J): ((Vmax * STEP_PKA) / (Km + STEP_PKA))[uM.s-1]
Km (1/2 max) (Km): 6.0[uM] max reaction rate (Vmax): (Kcat * PP1)[uM.s-1] user defined (Kcat): 5.0[s-1] |
Name |
Type
Electrical (Membrane Polarity)
|
---|---|
IC |
Compartment
(+) (-)
|
|
|
EC |
Compartment
(+) (-)
|
|
|
ER |
Compartment
(+) (-)
|
|
|
PM |
Membrane
N/A
|
|
|
ER_Membrane |
Membrane
N/A
|
|
|
Name | Structure | BioNetGen Definition |
---|---|---|
BDNF | EC | |
|
|
|
CaM_Ca4 | IC | |
|
|
|
PDE2_IBMX | IC | |
|
|
|
Gap | IC | |
|
|
|
R2C2_cAMP3 | IC | |
|
|
|
SoS_Pi_Grb2 | IC | |
|
|
|
PDE4_ERK_PKA | IC | |
|
|
|
Gby | PM | |
|
|
|
R2C2_cAMP | IC | |
|
|
|
AC5_Ga | PM | |
|
|
|
D1LR_Gqby | PM | |
|
|
|
PP1 | IC | |
|
|
|
DARPP32_Pi_PP1 | IC | |
|
|
|
I1_Pi_PP1 | IC | |
|
|
|
PDE4_ERK | IC | |
|
|
|
AMPAR_Bulk | IC | |
|
|
|
GluR1_Membrane | PM | |
|
|
|
Gqby | PM | |
|
|
|
PLC | PM | |
|
|
|
PLC_Ca | PM | |
|
|
|
PLC_Ca_Gq | PM | |
|
|
|
IP3_degraded | IC | |
|
|
|
IP3_14 | IC | |
|
|
|
IP3R | ER_Membrane | |
|
|
|
AC_basal | PM | |
|
|
|
G_by | PM | |
|
|
|
Gq_GDP | PM | |
|
|
|
PKC_active | IC | |
|
|
|
PP2A | IC | |
|
|
|
Da_D5R | PM | |
|
|
|
PP1_PDE | IC | |
|
|
|
cAMP | IC | |
|
|
|
Gaby | PM | |
|
|
|
U0126 | IC | |
|
|
|
DARPP32 | IC | |
|
|
|
Rolipram | IC | |
|
|
|
Da_D5R_Gaby | PM | |
|
|
|
AC5 | PM | |
|
|
|
R2C_cAMP4 | IC | |
|
|
|
PDE3_IBMX | IC | |
|
|
|
R2_cAMP4 | IC | |
|
|
|
BDNF_TrkB | PM | |
|
|
|
AC5_Fsk | PM | |
|
|
|
STEP_PKA | IC | |
|
|
|
BRaf_Pi | IC | |
|
|
|
D1R_Gaby | PM | |
|
|
|
Gq_GTP | PM | |
|
|
|
PDE1_CaM_Ca4 | IC | |
|
|
|
GluR1_845_818 | IC | |
|
|
|
Raf | IC | |
|
|
|
IBMX | IC | |
|
|
|
PDEbg | IC | |
|
|
|
PKA_active | IC | |
|
|
|
PDE1_IBMX | IC | |
|
|
|
TrkB | PM | |
|
|
|
GluR1_degraded | IC | |
|
|
|
GluR1 | IC | |
|
|
|
MEK_Ser | IC | |
|
|
|
IP3R_open | ER_Membrane | |
|
|
|
ERK_Tyr | IC | |
|
|
|
D1LR | PM | |
|
|
|
Da | EC | |
|
|
|
SERCA | ER_Membrane | |
|
|
|
SERCA_active | ER_Membrane | |
|
|
|
IP3_5pase1 | IC | |
|
|
|
PLC_Gq | PM | |
|
|
|
PDE4_PKA | IC | |
|
|
|
MEK | IC | |
|
|
|
Ga_GDP | PM | |
|
|
|
CaM | IC | |
|
|
|
Fsk | EC | |
|
|
|
Four1N | IC | |
|
|
|
PDE4_IBMX | IC | |
|
|
|
D5R_Gaby | PM | |
|
|
|
BDNF_TrkB2 | PM | |
|
|
|
I1_Pi | IC | |
|
|
|
ERK | IC | |
|
|
|
Ga_GTP | PM | |
|
|
|
PDE4_Rolipram | IC | |
|
|
|
PKA_Inhibitor | IC | |
|
|
|
CaMKII_286_CaM | IC | |
|
|
|
Ras_GDP | IC | |
|
|
|
MEK_inhibited | IC | |
|
|
|
R2C2_cAMP4 | IC | |
|
|
|
Ras_Raf_active | IC | |
|
|
|
Da_D1R_Gaby | PM | |
|
|
|
SoS_Grb2 | IC | |
|
|
|
ATP | IC | |
|
|
|
GluR1_845 | IC | |
|
|
|
IP3_5Pase2 | IC | |
|
|
|
Shc | IC | |
|
|
|
Ras_GTP | IC | |
|
|
|
R2C2 | IC | |
|
|
|
D1R | PM | |
|
|
|
PIP2 | PM | |
|
|
|
Da_D1LR_Gqby | PM | |
|
|
|
Int_TrkB2 | PM | |
|
|
|
CaMKII | IC | |
|
|
|
BRaf | IC | |
|
|
|
R2C2_cAMP2 | IC | |
|
|
|
PDE1 | IC | |
|
|
|
CaM_Ca2 | IC | |
|
|
|
PDE2 | IC | |
|
|
|
BDNF_TrkB2_Pi | IC | |
|
|
|
ERK_active | IC | |
|
|
|
Shc_Pi | IC | |
|
|
|
DAG | PM | |
|
|
|
IP3_145 | IC | |
|
|
|
MEK_active | IC | |
|
|
|
AMP | IC | |
|
|
|
Grb2 | IC | |
|
|
|
STEP | IC | |
|
|
|
PDE3 | IC | |
|
|
|
Calcium | IC | |
|
|
|
CaMKII_CaM | IC | |
|
|
|
SoS | IC | |
|
|
|
PDE4 | IC | |
|
|
|
CaMKII_286 | IC | |
|
|
|
Da_D1R | PM | |
|
|
|
SoS_Pi | IC | |
|
|
|
D5R | PM | |
|
|
|
PKA_inhibited | IC | |
|
|
|
CaM_Ca3 | IC | |
|
|
|
Calcium_ER | ER | |
|
|
|
GluR1_Membrane_dephosphorylated1 | PM | |
|
|
|
I1 | IC | |
|
|
|
Da_D1LR | PM | |
|
|
|
DARPP32_Pi | IC | |
|
|
|
Shc_Pi_SoS_Grb2 | IC | |
|
|
|
PP2A_DI | IC | |
|
|
Name | Text Annotations | BioNetGen Definition |
---|
Name |
Type
Count
|
BioNetGen Definition |
---|
Applications
Name | Math Type | Annotation |
---|---|---|
Application0 | Deterministic (ODE) Compartmental |
Application - Application0
Species | Initial Condition | Diffusion Constant | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CaM_Ca4 | 0.0 [uM] | 0.0
[um2/s] PDE2_IBMX |
0.0
[uM]
|
0.0
[um2/s] | Gap |
0.01
[uM]
|
1.0
[um2/s] | R2C2_cAMP3 |
0.0
[uM]
|
0.0
[um2/s] | SoS_Pi_Grb2 |
0.0
[uM]
|
1.0
[um2/s] | PDE4_ERK_PKA |
0.0
[uM]
|
0.0
[um2/s] | R2C2_cAMP |
0.0
[uM]
|
0.0
[um2/s] | PP1 |
0.25
[uM]
|
0.0
[um2/s] | DARPP32_Pi_PP1 |
0.0
[uM]
|
0.0
[um2/s] | I1_Pi_PP1 |
0.0
[uM]
|
0.0
[um2/s] | PDE4_ERK |
0.0
[uM]
|
0.0
[um2/s] | AMPAR_Bulk |
0.011111
[uM]
|
0.0
[um2/s] | IP3_degraded |
0.0
[uM]
|
0.0
[um2/s] | IP3_14 |
0.0
[uM]
|
0.0
[um2/s] | PKC_active |
0.05
[uM]
|
0.0
[um2/s] | PP2A |
0.2
[uM]
|
0.0
[um2/s] | PP1_PDE |
0.1
[uM]
|
0.0
[um2/s] | cAMP |
0.0
[uM]
|
0.0
[um2/s] | U0126 |
0.0
[uM]
|
0.0
[um2/s] | DARPP32 |
0.5
[uM]
|
0.0
[um2/s] | Rolipram |
0.0
[uM]
|
0.0
[um2/s] | R2C_cAMP4 |
0.0
[uM]
|
0.0
[um2/s] | PDE3_IBMX |
0.0
[uM]
|
0.0
[um2/s] | R2_cAMP4 |
0.0
[uM]
|
0.0
[um2/s] | STEP_PKA |
0.0
[uM]
|
0.0
[um2/s] | BRaf_Pi |
0.0
[uM]
|
0.0
[um2/s] | PDE1_CaM_Ca4 |
0.0
[uM]
|
0.0
[um2/s] | GluR1_845_818 |
0.0
[uM]
|
0.0
[um2/s] | Raf |
3.0
[uM]
|
1.0
[um2/s] | IBMX |
0.0
[uM]
|
0.0
[um2/s] | PDEbg |
3.0
[uM]
|
0.0
[um2/s] | PKA_active |
0.0
[uM]
|
0.0
[um2/s] | PDE1_IBMX |
0.0
[uM]
|
0.0
[um2/s] | GluR1_degraded |
0.0
[uM]
|
0.0
[um2/s] | GluR1 |
0.0
[uM]
|
0.0
[um2/s] | MEK_Ser |
0.0
[uM]
|
1.0
[um2/s] | ERK_Tyr |
0.0
[uM]
|
1.0
[um2/s] | IP3_5pase1 |
12.0
[uM]
|
0.0
[um2/s] | PDE4_PKA |
0.0
[uM]
|
0.0
[um2/s] | MEK |
0.18
[uM]
|
1.0
[um2/s] | CaM |
2.0
[uM]
|
0.0
[um2/s] | Four1N |
0.01
[uM]
|
0.0
[um2/s] | PDE4_IBMX |
0.0
[uM]
|
0.0
[um2/s] | I1_Pi |
0.0
[uM]
|
0.0
[um2/s] | ERK |
0.36
[uM]
|
1.0
[um2/s] | PDE4_Rolipram |
0.0
[uM]
|
0.0
[um2/s] | PKA_Inhibitor |
0.25
[uM]
|
0.0
[um2/s] | CaMKII_286_CaM |
0.0
[uM]
|
0.0
[um2/s] | Ras_GDP |
3.0
[uM]
|
1.0
[um2/s] | MEK_inhibited |
0.0
[uM]
|
0.0
[um2/s] | R2C2_cAMP4 |
0.0
[uM]
|
0.0
[um2/s] | Ras_Raf_active |
0.0
[uM]
|
1.0
[um2/s] | SoS_Grb2 |
0.0
[uM]
|
1.0
[um2/s] | ATP |
2000.0
[uM]
|
0.0
[um2/s] | GluR1_845 |
0.0
[uM]
|
0.0
[um2/s] | IP3_5Pase2 |
0.463
[uM]
|
0.0
[um2/s] | Shc |
1.0
[uM]
|
1.0
[um2/s] | Ras_GTP |
0.0
[uM]
|
1.0
[um2/s] | R2C2 |
0.5
[uM]
|
0.0
[um2/s] | CaMKII |
2.0
[uM]
|
0.0
[um2/s] | BRaf |
0.18
[uM]
|
0.0
[um2/s] | R2C2_cAMP2 |
0.0
[uM]
|
0.0
[um2/s] | PDE1 |
1.0
[uM]
|
0.0
[um2/s] | CaM_Ca2 |
0.0
[uM]
|
0.0
[um2/s] | PDE2 |
1.0
[uM]
|
0.0
[um2/s] | BDNF_TrkB2_Pi |
0.0
[uM]
|
0.0
[um2/s] | ERK_active |
0.0
[uM]
|
1.0
[um2/s] | Shc_Pi |
0.0
[uM]
|
1.0
[um2/s] | IP3_145 |
0.0
[uM]
|
0.0
[um2/s] | MEK_active |
0.0
[uM]
|
1.0
[um2/s] | AMP |
0.0
[uM]
|
0.0
[um2/s] | Grb2 |
1.0
[uM]
|
1.0
[um2/s] | STEP |
0.2
[uM]
|
0.0
[um2/s] | PDE3 |
0.005
[uM]
|
0.0
[um2/s] | Calcium |
0.08
[uM]
|
0.0
[um2/s] | CaMKII_CaM |
0.0
[uM]
|
0.0
[um2/s] | SoS |
1.0
[uM]
|
1.0
[um2/s] | PDE4 |
0.4
[uM]
|
0.0
[um2/s] | CaMKII_286 |
0.0
[uM]
|
0.0
[um2/s] | SoS_Pi |
0.0
[uM]
|
1.0
[um2/s] | PKA_inhibited |
0.0
[uM]
|
0.0
[um2/s] | CaM_Ca3 |
0.0
[uM]
|
0.0
[um2/s] | I1 |
0.68
[uM]
|
0.0
[um2/s] | |