ModelBricks - Model Print Page

Name - Song_PNAS_2013

BioModel ID - 84275910

Reaction Diagram

Physiology

Universal ID's	Text Annotations

Reactions See in Dashboard
Reaction	Name Structure	Kinetics	Depiction
CaM_Ca3+CalciumCaM_Ca4	091 IC	MassAction	CaM_Ca3+CalciumCaM_Ca4
		reaction rate (J): (((Kf * CaM_Ca3) * Calcium) - (Kr * CaM_Ca4))[uM.s-1] forward rate constant (Kf): 0.465[s-1.uM-1] reverse rate constant (Kr): 10.0[s-1]
Int_TrkB2TrkB	005 PM	MassAction	Int_TrkB2TrkB
		reaction rate (J): ((Kf * Int_TrkB2) - (Kr * TrkB))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 0.001[s-1] reverse rate constant (Kr): 0.001[s-1]
CalciumCalcium_ER	r44 ER_Membrane	GeneralKinetics	CalciumCalcium_ER
		reaction rate (J): (Kcat * SERCA_active * Calcium * Calcium / (0.0625 + (Calcium * Calcium)))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] user defined (Kcat): 10.0[s-1]
PDE1+IBMXPDE1_IBMX	r19 IC	MassAction	PDE1+IBMXPDE1_IBMX
		reaction rate (J): (((Kf * PDE1) * IBMX) - (Kr * PDE1_IBMX))[uM.s-1] forward rate constant (Kf): 8.0[s-1.uM-1] reverse rate constant (Kr): 0.8[s-1]
Da+D1LR_GqbyDa_D1LR_Gqby	r20 PM	MassAction	Da+D1LR_GqbyDa_D1LR_Gqby
		reaction rate (J): (((Kf * Da) * D1LR_Gqby) - (Kr * Da_D1LR_Gqby))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 3.33[s-1.uM-1] reverse rate constant (Kr): 10.0[s-1]
IP3_145IP3_14	r40 IC	HMMIrreversible	IP3_145IP3_14
		reaction rate (J): ((Vmax * IP3_145) / (Km + IP3_145))[uM.s-1] Km (1/2 max) (Km): 18.0[uM] max reaction rate (Vmax): (Kcat * IP3_5Pase2)[uM.s-1] user defined (Kcat): 10.667[s-1]
DARPP32_PiDARPP32	057 IC	HMMIrreversible	DARPP32_PiDARPP32
		reaction rate (J): ((Vmax * DARPP32_Pi) / (Km + DARPP32_Pi))[uM.s-1] Km (1/2 max) (Km): 0.37[uM] max reaction rate (Vmax): (Kcat * PP2A_DI)[uM.s-1] user defined (Kcat): 6.7[s-1]
Da_D1LR_GqbyG_by+Da_D1LR+Gq_GTP	r28 PM	MassAction	Da_D1LR_GqbyG_by+Da_D1LR+Gq_GTP
		reaction rate (J): ((Kf * Da_D1LR_Gqby) - (((Kr * G_by) * Da_D1LR) * Gq_GTP))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 20.0[s-1] reverse rate constant (Kr): 0.0[um4.s-1.molecules-2]
R2C_cAMP4PKA_active+R2_cAMP4	087 IC	MassAction	R2C_cAMP4PKA_active+R2_cAMP4
		reaction rate (J): ((Kf * R2C_cAMP4) - ((Kr * PKA_active) * R2_cAMP4))[uM.s-1] forward rate constant (Kf): 60.0[s-1] reverse rate constant (Kr): 18.0[s-1.uM-1]
Rolipram+PDE4_ERK_PKAPDE4_Rolipram	r10 IC	MassAction	Rolipram+PDE4_ERK_PKAPDE4_Rolipram
		reaction rate (J): (((Kf * Rolipram) * PDE4_ERK_PKA) - (Kr * PDE4_Rolipram))[uM.s-1] forward rate constant (Kf): 1.0[s-1.uM-1] reverse rate constant (Kr): 0.019[s-1]
AC5+FskAC5_Fsk	r7 PM	MassAction	AC5+FskAC5_Fsk
		reaction rate (J): (((Kf * AC5) * Fsk) - (Kr * AC5_Fsk))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 0.026[s-1.uM-1] reverse rate constant (Kr): 1.0[s-1]
IBMX+PDE4PDE4_IBMX	r21 IC	MassAction	IBMX+PDE4PDE4_IBMX
		reaction rate (J): (((Kf * IBMX) * PDE4) - (Kr * PDE4_IBMX))[uM.s-1] forward rate constant (Kf): 8.0[s-1.uM-1] reverse rate constant (Kr): 0.8[s-1]
CaMKII_286CaMKII	096 IC	HMMIrreversible	CaMKII_286CaMKII
		reaction rate (J): ((Vmax * CaMKII_286) / (Km + CaMKII_286))[uM.s-1] Km (1/2 max) (Km): 5.1[uM] max reaction rate (Vmax): (Kcat * PP1)[uM.s-1] user defined (Kcat): 0.35[s-1]
DARPP32DARPP32_Pi	056 IC	HMMIrreversible	DARPP32DARPP32_Pi
		reaction rate (J): ((Vmax * DARPP32) / (Km + DARPP32))[uM.s-1] Km (1/2 max) (Km): 2.4[uM] max reaction rate (Vmax): (Kcat * PKA_active)[uM.s-1] user defined (Kcat): 2.7[s-1]
ERKERK_Tyr	036 IC	HMMIrreversible	ERKERK_Tyr
		reaction rate (J): ((Vmax * ERK) / (Km + ERK))[uM.s-1] Km (1/2 max) (Km): 0.046296[uM] max reaction rate (Vmax): (Kcat * MEK_active)[uM.s-1] user defined (Kcat): 0.15[s-1]
Da+D1RDa_D1R	064 PM	MassAction	Da+D1RDa_D1R
		reaction rate (J): (((Kf * Da) * D1R) - (Kr * Da_D1R))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 1.11[s-1.uM-1] reverse rate constant (Kr): 10.0[s-1]
cAMPAMP	r52 IC	HMMIrreversible	cAMPAMP
		reaction rate (J): ((Vmax * cAMP) / (Km + cAMP))[uM.s-1] Km (1/2 max) (Km): 90.0[uM] max reaction rate (Vmax): (Kcat * PDEbg)[uM.s-1] user defined (Kcat): 20.0[s-1]
cAMPAMP	078 IC	HMMIrreversible	cAMPAMP
		reaction rate (J): ((Vmax * cAMP) / (Km + cAMP))[uM.s-1] Km (1/2 max) (Km): 1.8[uM] max reaction rate (Vmax): (Kcat * PDE4_ERK_PKA)[uM.s-1] user defined (Kcat): 8.0[s-1]
Four1N+GluR1_845_818GluR1_Membrane	103 PM	MassAction	Four1N+GluR1_845_818GluR1_Membrane
		reaction rate (J): (((Kf * Four1N) * GluR1_845_818) - (Kr * GluR1_Membrane))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 0.0108[molecules.um-2.s-1.uM-2] reverse rate constant (Kr): 0.008[s-1]
Ga_GDP+GbyGaby	073 PM	MassAction	Ga_GDP+GbyGaby
		reaction rate (J): (((Kf * Ga_GDP) * Gby) - (Kr * Gaby))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 100.0[um2.s-1.molecules-1] reverse rate constant (Kr): 0.0[s-1]
IP3_145IP3_degraded	r38 IC	MassAction	IP3_145IP3_degraded
		reaction rate (J): ((Kf * IP3_145) - (Kr * IP3_degraded))[uM.s-1] forward rate constant (Kf): 2.5[s-1] reverse rate constant (Kr): 0.0[s-1]
cAMPAMP	r12 IC	HMMIrreversible	cAMPAMP
		reaction rate (J): ((Vmax * cAMP) / (Km + cAMP))[uM.s-1] Km (1/2 max) (Km): 0.3[uM] max reaction rate (Vmax): (Kcat * PDE3)[uM.s-1] user defined (Kcat): 30.0[s-1]
PDE3+IBMXPDE3_IBMX	r6 IC	MassAction	PDE3+IBMXPDE3_IBMX
		reaction rate (J): (((Kf * PDE3) * IBMX) - (Kr * PDE3_IBMX))[uM.s-1] forward rate constant (Kf): 8.0[s-1.uM-1] reverse rate constant (Kr): 0.8[s-1]
AMPAR_BulkGluR1	100 IC	MassAction	AMPAR_BulkGluR1
		reaction rate (J): ((Kf * AMPAR_Bulk) - (Kr * GluR1))[uM.s-1] forward rate constant (Kf): 0.018[s-1] reverse rate constant (Kr): 1.0[s-1]
Da_D5R_GabyDa_D5R+Gby+Ga_GTP	r0 PM	MassAction	Da_D5R_GabyDa_D5R+Gby+Ga_GTP
		reaction rate (J): ((Kf * Da_D5R_Gaby) - (((Kr * Da_D5R) * Gby) * Ga_GTP))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 20.0[s-1] reverse rate constant (Kr): 0.0[um4.s-1.molecules-2]
Rolipram+PDE4_PKAPDE4_Rolipram	r11 IC	MassAction	Rolipram+PDE4_PKAPDE4_Rolipram
		reaction rate (J): (((Kf * Rolipram) * PDE4_PKA) - (Kr * PDE4_Rolipram))[uM.s-1] forward rate constant (Kf): 1.0[s-1.uM-1] reverse rate constant (Kr): 0.019[s-1]
ATPcAMP	r3 PM	HMMIrreversible	ATPcAMP
		reaction rate (J): ((Vmax * ATP) / (Km + ATP))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] Km (1/2 max) (Km): 20.1149[uM] max reaction rate (Vmax): (Kcat * AC_basal)[molecules.um-2.s-1] user defined (Kcat): 7.0[s-1]
PDE4_ERK_PKAPDE4	r55 IC	HMMIrreversible	PDE4_ERK_PKAPDE4
		reaction rate (J): ((Vmax * PDE4_ERK_PKA) / (Km + PDE4_ERK_PKA))[uM.s-1] Km (1/2 max) (Km): 8.0[uM] max reaction rate (Vmax): (Kcat * PP1_PDE)[uM.s-1] user defined (Kcat): 1.0[s-1]
ShcShc_Pi	011 IC	HMMIrreversible	ShcShc_Pi
		reaction rate (J): ((Vmax * Shc) / (Km + Shc))[uM.s-1] Km (1/2 max) (Km): 0.83331[uM] max reaction rate (Vmax): (0.3 * BDNF_TrkB2_Pi)[uM.s-1]
SoSSoS_Pi	012 IC	HMMIrreversible	SoSSoS_Pi
		reaction rate (J): ((Vmax * SoS) / (Km + SoS))[uM.s-1] Km (1/2 max) (Km): 25.641[uM] max reaction rate (Vmax): (10.0 * ERK_active)[uM.s-1]
CaMKII_286_CaMCaMKII_CaM	097 IC	HMMIrreversible	CaMKII_286_CaMCaMKII_CaM
		reaction rate (J): ((Vmax * CaMKII_286_CaM) / (Km + CaMKII_286_CaM))[uM.s-1] Km (1/2 max) (Km): 5.1[uM] max reaction rate (Vmax): (Kcat * PP1)[uM.s-1] user defined (Kcat): 0.35[s-1]
Da_D5R+GabyDa_D5R_Gaby	071 PM	MassAction	Da_D5R+GabyDa_D5R_Gaby
		reaction rate (J): (((Kf * Da_D5R) * Gaby) - (Kr * Da_D5R_Gaby))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 0.6[um2.s-1.molecules-1] reverse rate constant (Kr): 0.001[s-1]
TrkB+BDNF_TrkBBDNF_TrkB2	002 PM	MassAction	TrkB+BDNF_TrkBBDNF_TrkB2
		reaction rate (J): (((Kf * TrkB) * BDNF_TrkB) - (Kr * BDNF_TrkB2))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 1.0[um2.s-1.molecules-1] reverse rate constant (Kr): 0.02[s-1]
PLC+CalciumPLC_Ca	r35 PM	MassAction	PLC+CalciumPLC_Ca
		reaction rate (J): (((Kf * PLC) * Calcium) - (Kr * PLC_Ca))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 1.0[s-1.uM-1] reverse rate constant (Kr): 1.0[s-1]
Ras_GTPRas_GDP	023 IC	HMMIrreversible	Ras_GTPRas_GDP
		reaction rate (J): ((Vmax * Ras_GTP) / (Km + Ras_GTP))[uM.s-1] Km (1/2 max) (Km): 1.0104[uM] max reaction rate (Vmax): (10.0 * Gap)[uM.s-1]
BDNF+TrkBBDNF_TrkB	001 PM	MassAction	BDNF+TrkBBDNF_TrkB
		reaction rate (J): (((Kf * BDNF) * TrkB) - (Kr * BDNF_TrkB))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 1.0[s-1.uM-1] reverse rate constant (Kr): 0.05[s-1]
PLC_GqGq_GDP+PLC	r36 PM	MassAction	PLC_GqGq_GDP+PLC
		reaction rate (J): ((Kf * PLC_Gq) - ((Kr * Gq_GDP) * PLC))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 0.094[s-1] reverse rate constant (Kr): 0.0[um2.s-1.molecules-1]
R2C2_cAMP2+cAMPR2C2_cAMP3	084 IC	MassAction	R2C2_cAMP2+cAMPR2C2_cAMP3
		reaction rate (J): (((Kf * R2C2_cAMP2) * cAMP) - (Kr * R2C2_cAMP3))[uM.s-1] forward rate constant (Kf): 75.0[s-1.uM-1] reverse rate constant (Kr): 110.0[s-1]
PDE1+CaM_Ca4PDE1_CaM_Ca4	098 IC	MassAction	PDE1+CaM_Ca4PDE1_CaM_Ca4
		reaction rate (J): (((Kf * PDE1) * CaM_Ca4) - (Kr * PDE1_CaM_Ca4))[uM.s-1] forward rate constant (Kf): 0.1[s-1.uM-1] reverse rate constant (Kr): 1.0[s-1]
Da+D1LRDa_D1LR	r26 PM	MassAction	Da+D1LRDa_D1LR
		reaction rate (J): (((Kf * Da) * D1LR) - (Kr * Da_D1LR))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 1.11[s-1.uM-1] reverse rate constant (Kr): 10.0[s-1]
cAMPAMP	081 IC	HMMIrreversible	cAMPAMP
		reaction rate (J): ((Vmax * cAMP) / (Km + cAMP))[uM.s-1] Km (1/2 max) (Km): 39.683[uM] max reaction rate (Vmax): (Kcat * PDE1_CaM_Ca4)[uM.s-1] user defined (Kcat): 10.0[s-1]
GluR1_Membrane_dephosphorylated1GluR1+Four1N	104 PM	MassAction	GluR1_Membrane_dephosphorylated1GluR1+Four1N
		reaction rate (J): ((Kf * GluR1_Membrane_dephosphorylated1) - ((Kr * GluR1) * Four1N))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 8.0E-4[s-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-2]
cAMPAMP	077 IC	HMMIrreversible	cAMPAMP
		reaction rate (J): ((Vmax * cAMP) / (Km + cAMP))[uM.s-1] Km (1/2 max) (Km): 1.8[uM] max reaction rate (Vmax): (Kcat * PDE4)[uM.s-1] user defined (Kcat): 10.0[s-1]
MEK_SerMEK	032 IC	HMMIrreversible	MEK_SerMEK
		reaction rate (J): ((Vmax * MEK_Ser) / (Km + MEK_Ser))[uM.s-1] Km (1/2 max) (Km): 15.657[uM] max reaction rate (Vmax): (Kcat * PP2A)[uM.s-1] user defined (Kcat): 6.0[s-1]
SoS_Pi+Grb2SoS_Pi_Grb2	008 IC	MassAction	SoS_Pi+Grb2SoS_Pi_Grb2
		reaction rate (J): (((Kf * SoS_Pi) * Grb2) - (Kr * SoS_Pi_Grb2))[uM.s-1] forward rate constant (Kf): 0.025[s-1.uM-1] reverse rate constant (Kr): 0.0168[s-1]
Shc_PiShc	006 IC	MassAction	Shc_PiShc
		reaction rate (J): ((Kf * Shc_Pi) - (Kr * Shc))[uM.s-1] forward rate constant (Kf): 1.0E-4[s-1] reverse rate constant (Kr): 0.0[s-1]
Da_D1LR+GqbyDa_D1LR_Gqby	r27 PM	MassAction	Da_D1LR+GqbyDa_D1LR_Gqby
		reaction rate (J): (((Kf * Da_D1LR) * Gqby) - (Kr * Da_D1LR_Gqby))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 0.6[um2.s-1.molecules-1] reverse rate constant (Kr): 0.001[s-1]
PDE4_PKAPDE4	046 IC	HMMIrreversible	PDE4_PKAPDE4
		reaction rate (J): ((Vmax * PDE4_PKA) / (Km + PDE4_PKA))[uM.s-1] Km (1/2 max) (Km): 8.0[uM] max reaction rate (Vmax): (Kcat * PP1_PDE)[uM.s-1] user defined (Kcat): 5.0[s-1]
I1I1_Pi	060 IC	HMMIrreversible	I1I1_Pi
		reaction rate (J): ((Vmax * I1) / (Km + I1))[uM.s-1] Km (1/2 max) (Km): 7.5[uM] max reaction rate (Vmax): (Kcat * PKA_active)[uM.s-1] user defined (Kcat): 6.0[s-1]
Ras_GDPRas_GTP	018 IC	HMMIrreversible	Ras_GDPRas_GTP
		reaction rate (J): ((Vmax * Ras_GDP) / (Km + Ras_GDP))[uM.s-1] Km (1/2 max) (Km): 0.50505[uM] max reaction rate (Vmax): (0.2 * Shc_Pi_SoS_Grb2)[uM.s-1]
cAMPAMP	r48 IC	HMMIrreversible	cAMPAMP
		reaction rate (J): ((Vmax * cAMP) / (Km + cAMP))[uM.s-1] Km (1/2 max) (Km): 1.8[uM] max reaction rate (Vmax): (Kcat * PDE4_ERK)[uM.s-1] user defined (Kcat): 0.01[s-1]
PDE4PDE4_PKA	045 IC	HMMIrreversible	PDE4PDE4_PKA
		reaction rate (J): ((Vmax * PDE4) / (Km + PDE4))[uM.s-1] Km (1/2 max) (Km): 7.5[uM] max reaction rate (Vmax): (Kcat * PKA_active)[uM.s-1] user defined (Kcat): 3.0[s-1]
Ga_GTP+AC5AC5_Ga	075 PM	MassAction	Ga_GTP+AC5AC5_Ga
		reaction rate (J): (((Kf * Ga_GTP) * AC5) - (Kr * AC5_Ga))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 38.5[um2.s-1.molecules-1] reverse rate constant (Kr): 50.0[s-1]
SoS_PiSoS	009 IC	MassAction	SoS_PiSoS
		reaction rate (J): ((Kf * SoS_Pi) - (Kr * SoS))[uM.s-1] forward rate constant (Kf): 0.001[s-1] reverse rate constant (Kr): 0.0[s-1]
cAMPAMP	r50 IC	HMMIrreversible	cAMPAMP
		reaction rate (J): ((Vmax * cAMP) / (Km + cAMP))[uM.s-1] Km (1/2 max) (Km): 30.0[uM] max reaction rate (Vmax): (Kcat * PDE2)[uM.s-1] user defined (Kcat): 12.0[s-1]
BDNF_TrkB2_PiInt_TrkB2	004 PM	MassAction	BDNF_TrkB2_PiInt_TrkB2
		reaction rate (J): ((Kf * BDNF_TrkB2_Pi) - (Kr * Int_TrkB2))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 1.0E-4[molecules.um-2.s-1.uM-1] reverse rate constant (Kr): 0.0[s-1]
GluR1_845_818GluR1_845	r56 IC	HMMIrreversible	GluR1_845_818GluR1_845
		reaction rate (J): ((Vmax * GluR1_845_818) / (Km + GluR1_845_818))[uM.s-1] Km (1/2 max) (Km): 0.97145[uM] max reaction rate (Vmax): (Kcat * PP1)[uM.s-1] user defined (Kcat): 0.17[s-1]
PLC_Gq+CalciumPLC_Ca_Gq	r37 PM	MassAction	PLC_Gq+CalciumPLC_Ca_Gq
		reaction rate (J): (((Kf * PLC_Gq) * Calcium) - (Kr * PLC_Ca_Gq))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 30.0[s-1.uM-1] reverse rate constant (Kr): 1.0[s-1]
PIP2DAG+IP3_145	r32 PM	HMMIrreversible	PIP2DAG+IP3_145
		reaction rate (J): ((Vmax * PIP2) / (Km + PIP2))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] Km (1/2 max) (Km): 5.0[molecules.um-2] max reaction rate (Vmax): (Kcat * PLC_Ca_Gq)[molecules.um-2.s-1] user defined (Kcat): 48.0[s-1]
SoS_Grb2+Shc_PiShc_Pi_SoS_Grb2	007 IC	MassAction	SoS_Grb2+Shc_PiShc_Pi_SoS_Grb2
		reaction rate (J): (((Kf * SoS_Grb2) * Shc_Pi) - (Kr * Shc_Pi_SoS_Grb2))[uM.s-1] forward rate constant (Kf): 0.5[s-1.uM-1] reverse rate constant (Kr): 0.1[s-1]
GluR1GluR1_845	106 IC	HMMIrreversible	GluR1GluR1_845
		reaction rate (J): ((Vmax * GluR1) / (Km + GluR1))[uM.s-1] Km (1/2 max) (Km): 7.5002[uM] max reaction rate (Vmax): (Kcat * PKA_active)[uM.s-1] user defined (Kcat): 6.0[s-1]
Gq_GDP+G_byGqby	r29 PM	MassAction	Gq_GDP+G_byGqby
		reaction rate (J): (((Kf * Gq_GDP) * G_by) - (Kr * Gqby))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 100.0[um2.s-1.molecules-1] reverse rate constant (Kr): 0.0[s-1]
D1R_Gaby+DaDa_D1R_Gaby	067 PM	MassAction	D1R_Gaby+DaDa_D1R_Gaby
		reaction rate (J): (((Kf * D1R_Gaby) * Da) - (Kr * Da_D1R_Gaby))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 3.33[s-1.uM-1] reverse rate constant (Kr): 10.0[s-1]
PKA_active+PKA_InhibitorPKA_inhibited	088 IC	MassAction	PKA_active+PKA_InhibitorPKA_inhibited
		reaction rate (J): (((Kf * PKA_active) * PKA_Inhibitor) - (Kr * PKA_inhibited))[uM.s-1] forward rate constant (Kf): 60.0[s-1.uM-1] reverse rate constant (Kr): 1.0[s-1]
PDE4_ERK+IBMXPDE4_IBMX	r24 IC	MassAction	PDE4_ERK+IBMXPDE4_IBMX
		reaction rate (J): (((Kf * PDE4_ERK) * IBMX) - (Kr * PDE4_IBMX))[uM.s-1] forward rate constant (Kf): 8.0[s-1.uM-1] reverse rate constant (Kr): 0.8[s-1]
PIP2IP3_145+DAG	r31 PM	HMMIrreversible	PIP2IP3_145+DAG
		reaction rate (J): ((Vmax * PIP2) / (Km + PIP2))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] Km (1/2 max) (Km): 5.0[molecules.um-2] max reaction rate (Vmax): (Kcat * PLC_Gq)[molecules.um-2.s-1] user defined (Kcat): 75.0[s-1]
PDE4_PKA+IBMXPDE4_IBMX	r22 IC	MassAction	PDE4_PKA+IBMXPDE4_IBMX
		reaction rate (J): (((Kf * PDE4_PKA) * IBMX) - (Kr * PDE4_IBMX))[uM.s-1] forward rate constant (Kf): 8.0[s-1.uM-1] reverse rate constant (Kr): 0.8[s-1]
PLC+Gq_GTPPLC_Gq	r34 PM	MassAction	PLC+Gq_GTPPLC_Gq
		reaction rate (J): (((Kf * PLC) * Gq_GTP) - (Kr * PLC_Gq))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 0.25[um2.s-1.molecules-1] reverse rate constant (Kr): 0.003[s-1]
Grb2+SoSSoS_Grb2	010 IC	MassAction	Grb2+SoSSoS_Grb2
		reaction rate (J): (((Kf * Grb2) * SoS) - (Kr * SoS_Grb2))[uM.s-1] forward rate constant (Kf): 0.025[s-1.uM-1] reverse rate constant (Kr): 0.0168[s-1]
DARPP32_Pi+PP1DARPP32_Pi_PP1	r18 IC	MassAction	DARPP32_Pi+PP1DARPP32_Pi_PP1
		reaction rate (J): (((Kf * DARPP32_Pi) * PP1) - (Kr * DARPP32_Pi_PP1))[uM.s-1] forward rate constant (Kf): 100.0[s-1.uM-1] reverse rate constant (Kr): 0.2[s-1]
ATPcAMP	r1 PM	HMMIrreversible	ATPcAMP
		reaction rate (J): ((Vmax * ATP) / (Km + ATP))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] Km (1/2 max) (Km): 315.0[uM] max reaction rate (Vmax): (Kcat * AC5_Ga)[molecules.um-2.s-1] user defined (Kcat): 8.5[s-1]
ERK_activeERK_Tyr	r49 IC	HMMIrreversible	ERK_activeERK_Tyr
		reaction rate (J): ((Vmax * ERK_active) / (Km + ERK_active))[uM.s-1] Km (1/2 max) (Km): 0.77[uM] max reaction rate (Vmax): (Kcat * PP2A)[uM.s-1] user defined (Kcat): 0.636[s-1]
GluR1_MembraneGluR1_degraded	105 PM	MassAction	GluR1_MembraneGluR1_degraded
		reaction rate (J): ((Kf * GluR1_Membrane) - (Kr * GluR1_degraded))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 3.6E-5[s-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-1]
MEKMEK_Ser	034 IC	HMMIrreversible	MEKMEK_Ser
		reaction rate (J): ((Vmax * MEK) / (Km + MEK))[uM.s-1] Km (1/2 max) (Km): 0.15909[uM] max reaction rate (Vmax): (Kcat * BRaf_Pi)[uM.s-1] user defined (Kcat): 0.18[s-1]
BRaf_PiBRaf	063 IC	HMMIrreversible	BRaf_PiBRaf
		reaction rate (J): ((Vmax * BRaf_Pi) / (Km + BRaf_Pi))[uM.s-1] Km (1/2 max) (Km): 15.657[uM] max reaction rate (Vmax): (Kcat * PP2A)[uM.s-1] user defined (Kcat): 6.0[s-1]
DARPP32_Pi_PP1PP1+DARPP32	r47 IC	MassAction	DARPP32_Pi_PP1PP1+DARPP32
		reaction rate (J): ((Kf * DARPP32_Pi_PP1) - ((Kr * PP1) * DARPP32))[uM.s-1] forward rate constant (Kf): 10.0[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1]
CaMKII_CaMCaMKII_286_CaM	095 IC	HMMIrreversible	CaMKII_CaMCaMKII_286_CaM
		reaction rate (J): ((Vmax * CaMKII_CaM) / (Km + CaMKII_CaM))[uM.s-1] Km (1/2 max) (Km): 113.6[uM] max reaction rate (Vmax): (Kcat * CaMKII)[uM.s-1] user defined (Kcat): 0.5[s-1]
Gaby+D1RD1R_Gaby	065 PM	MassAction	Gaby+D1RD1R_Gaby
		reaction rate (J): (((Kf * Gaby) * D1R) - (Kr * D1R_Gaby))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 0.06[um2.s-1.molecules-1] reverse rate constant (Kr): 3.0E-4[s-1]
PDE2+IBMXPDE2_IBMX	r51 IC	MassAction	PDE2+IBMXPDE2_IBMX
		reaction rate (J): (((Kf * PDE2) * IBMX) - (Kr * PDE2_IBMX))[uM.s-1] forward rate constant (Kf): 8.0[s-1.uM-1] reverse rate constant (Kr): 0.8[s-1]
MEK_SerMEK_active	029 IC	HMMIrreversible	MEK_SerMEK_active
		reaction rate (J): ((Vmax * MEK_Ser) / (Km + MEK_Ser))[uM.s-1] Km (1/2 max) (Km): 0.15909[uM] max reaction rate (Vmax): (0.3 * Ras_Raf_active)[uM.s-1]
CaM+CalciumCaM_Ca2	089 IC	MassAction	CaM+CalciumCaM_Ca2
		reaction rate (J): (((Kf * CaM) * pow(Calcium,2.0)) - (Kr * CaM_Ca2))[uM.s-1] forward rate constant (Kf): 72.0[s-1.uM-2] reverse rate constant (Kr): 72.0[s-1]
Calcium_ERCalcium	r43 ER_Membrane	MassAction	Calcium_ERCalcium
		reaction rate (J): ((Kf * Calcium_ER) - (Kr * Calcium))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 5.34E-4[molecules.um-2.s-1.uM-1] reverse rate constant (Kr): 5.34E-4[molecules.um-2.s-1.uM-1]
I1_Pi+PP1I1_Pi_PP1	r53 IC	MassAction	I1_Pi+PP1I1_Pi_PP1
		reaction rate (J): (((Kf * I1_Pi) * PP1) - (Kr * I1_Pi_PP1))[uM.s-1] forward rate constant (Kf): 150.0[s-1.uM-1] reverse rate constant (Kr): 0.1[s-1]
PIP2DAG+IP3_145	r33 PM	HMMIrreversible	PIP2DAG+IP3_145
		reaction rate (J): ((Vmax * PIP2) / (Km + PIP2))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] Km (1/2 max) (Km): 19.8413[molecules.um-2] max reaction rate (Vmax): (Kcat * PLC_Ca)[molecules.um-2.s-1] user defined (Kcat): 10.0[s-1]
R2C2+cAMPR2C2_cAMP	082 IC	MassAction	R2C2+cAMPR2C2_cAMP
		reaction rate (J): (((Kf * R2C2) * cAMP) - (Kr * R2C2_cAMP))[uM.s-1] forward rate constant (Kf): 54.0[s-1.uM-1] reverse rate constant (Kr): 33.0[s-1]
STEPSTEP_PKA	040 IC	HMMIrreversible	STEPSTEP_PKA
		reaction rate (J): ((Vmax * STEP) / (Km + STEP))[uM.s-1] Km (1/2 max) (Km): 25.641[uM] max reaction rate (Vmax): (Kcat * PKA_active)[uM.s-1] user defined (Kcat): 1.0[s-1]
PDE4+RolipramPDE4_Rolipram	r9 IC	MassAction	PDE4+RolipramPDE4_Rolipram
		reaction rate (J): (((Kf * PDE4) * Rolipram) - (Kr * PDE4_Rolipram))[uM.s-1] forward rate constant (Kf): 1.0[s-1.uM-1] reverse rate constant (Kr): 0.019[s-1]
PDE4_ERKPDE4_ERK_PKA	052 IC	HMMIrreversible	PDE4_ERKPDE4_ERK_PKA
		reaction rate (J): ((Vmax * PDE4_ERK) / (Km + PDE4_ERK))[uM.s-1] Km (1/2 max) (Km): 7.5[uM] max reaction rate (Vmax): (Kcat * PKA_active)[uM.s-1] user defined (Kcat): 0.1[s-1]
Da+D5R_GabyDa_D5R_Gaby	070 PM	MassAction	Da+D5R_GabyDa_D5R_Gaby
		reaction rate (J): (((Kf * Da) * D5R_Gaby) - (Kr * Da_D5R_Gaby))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 3.33[s-1.uM-1] reverse rate constant (Kr): 1.0[s-1]
Gq_GTPGq_GDP	r30 PM	MassAction	Gq_GTPGq_GDP
		reaction rate (J): ((Kf * Gq_GTP) - (Kr * Gq_GDP))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 10.0[s-1] reverse rate constant (Kr): 0.0[s-1]
Gaby+D5RD5R_Gaby	069 PM	MassAction	Gaby+D5RD5R_Gaby
		reaction rate (J): (((Kf * Gaby) * D5R) - (Kr * D5R_Gaby))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 0.06[um2.s-1.molecules-1] reverse rate constant (Kr): 3.0E-4[s-1]
cAMPAMP	079 IC	HMMIrreversible	cAMPAMP
		reaction rate (J): ((Vmax * cAMP) / (Km + cAMP))[uM.s-1] Km (1/2 max) (Km): 1.8[uM] max reaction rate (Vmax): (Kcat * PDE4_PKA)[uM.s-1] user defined (Kcat): 27.0[s-1]
ATPcAMP	r4 PM	HMMIrreversible	ATPcAMP
		reaction rate (J): ((Vmax * ATP) / (Km + ATP))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] Km (1/2 max) (Km): 1030.0[uM] max reaction rate (Vmax): (Kcat * AC5)[molecules.um-2.s-1] user defined (Kcat): 0.2[s-1]
ERK_TyrERK_active	037 IC	HMMIrreversible	ERK_TyrERK_active
		reaction rate (J): ((Vmax * ERK_Tyr) / (Km + ERK_Tyr))[uM.s-1] Km (1/2 max) (Km): 0.046296[uM] max reaction rate (Vmax): (Kcat * MEK_active)[uM.s-1] user defined (Kcat): 0.15[s-1]
Ras_GTP+RafRas_Raf_active	016 IC	MassAction	Ras_GTP+RafRas_Raf_active
		reaction rate (J): (((Kf * Ras_GTP) * Raf) - (Kr * Ras_Raf_active))[uM.s-1] forward rate constant (Kf): 6.0[s-1.uM-1] reverse rate constant (Kr): 1.0[s-1]
Ga_GTPGa_GDP	074 PM	MassAction	Ga_GTPGa_GDP
		reaction rate (J): ((Kf * Ga_GTP) - (Kr * Ga_GDP))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 10.0[s-1] reverse rate constant (Kr): 0.0[s-1]
CaMKII_286+CaM_Ca4CaMKII_286_CaM	093 IC	MassAction	CaMKII_286+CaM_Ca4CaMKII_286_CaM
		reaction rate (J): (((Kf * CaMKII_286) * CaM_Ca4) - (Kr * CaMKII_286_CaM))[uM.s-1] forward rate constant (Kf): 1000.0[s-1.uM-1] reverse rate constant (Kr): 0.1[s-1]
I1_Pi_PP1PP1+I1	r54 IC	MassAction	I1_Pi_PP1PP1+I1
		reaction rate (J): ((Kf * I1_Pi_PP1) - ((Kr * PP1) * I1))[uM.s-1] forward rate constant (Kf): 1.0[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1]
cAMPAMP	080 IC	HMMIrreversible	cAMPAMP
		reaction rate (J): ((Vmax * cAMP) / (Km + cAMP))[uM.s-1] Km (1/2 max) (Km): 39.7[uM] max reaction rate (Vmax): (Kcat * PDE1)[uM.s-1] user defined (Kcat): 1.667[s-1]
Da_D1R_GabyGby+Ga_GTP+Da_D1R	072 PM	MassAction	Da_D1R_GabyGby+Ga_GTP+Da_D1R
		reaction rate (J): ((Kf * Da_D1R_Gaby) - (((Kr * Gby) * Ga_GTP) * Da_D1R))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 20.0[s-1] reverse rate constant (Kr): 0.0[um4.s-1.molecules-2]
PDE4_PKAPDE4_ERK_PKA	049 IC	HMMIrreversible	PDE4_PKAPDE4_ERK_PKA
		reaction rate (J): ((Vmax * PDE4_PKA) / (Km + PDE4_PKA))[uM.s-1] Km (1/2 max) (Km): 25.641[uM] max reaction rate (Vmax): (Kcat * ERK_active)[uM.s-1] user defined (Kcat): 0.1[s-1]
MEK+U0126MEK_inhibited	r16 IC	MassAction	MEK+U0126MEK_inhibited
		reaction rate (J): (((Kf * MEK) * U0126) - (Kr * MEK_inhibited))[uM.s-1] forward rate constant (Kf): 1.0[s-1.uM-1] reverse rate constant (Kr): 0.03[s-1]
IP3_145IP3_14	r39 IC	HMMIrreversible	IP3_145IP3_14
		reaction rate (J): ((Vmax * IP3_145) / (Km + IP3_145))[uM.s-1] Km (1/2 max) (Km): 3.0[uM] max reaction rate (Vmax): (Kcat * IP3_5pase1)[uM.s-1] user defined (Kcat): 1.1[s-1]
D5R+DaDa_D5R	068 PM	MassAction	D5R+DaDa_D5R
		reaction rate (J): (((Kf * D5R) * Da) - (Kr * Da_D5R))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 1.11[s-1.uM-1] reverse rate constant (Kr): 1.0[s-1]
PDE4PDE4_ERK	047 IC	HMMIrreversible	PDE4PDE4_ERK
		reaction rate (J): ((Vmax * PDE4) / (Km + PDE4))[uM.s-1] Km (1/2 max) (Km): 0.47[uM] max reaction rate (Vmax): (Kcat * ERK_active)[uM.s-1] user defined (Kcat): 10.0[s-1]
PDE1_CaM_Ca4+IBMXPDE1_IBMX	r5 IC	MassAction	PDE1_CaM_Ca4+IBMXPDE1_IBMX
		reaction rate (J): (((Kf * PDE1_CaM_Ca4) * IBMX) - (Kr * PDE1_IBMX))[uM.s-1] forward rate constant (Kf): 8.0[s-1.uM-1] reverse rate constant (Kr): 0.8[s-1]
ERK_TyrERK	044 IC	HMMIrreversible	ERK_TyrERK
		reaction rate (J): ((Vmax * ERK_Tyr) / (Km + ERK_Tyr))[uM.s-1] Km (1/2 max) (Km): 9.0[uM] max reaction rate (Vmax): (Kcat * STEP_PKA)[uM.s-1] user defined (Kcat): 0.1[s-1]
cAMP+R2C2_cAMPR2C2_cAMP2	083 IC	MassAction	cAMP+R2C2_cAMPR2C2_cAMP2
		reaction rate (J): (((Kf * cAMP) * R2C2_cAMP) - (Kr * R2C2_cAMP2))[uM.s-1] forward rate constant (Kf): 54.0[s-1.uM-1] reverse rate constant (Kr): 33.0[s-1]
CaM_Ca2+CalciumCaM_Ca3	090 IC	MassAction	CaM_Ca2+CalciumCaM_Ca3
		reaction rate (J): (((Kf * CaM_Ca2) * Calcium) - (Kr * CaM_Ca3))[uM.s-1] forward rate constant (Kf): 3.6[s-1.uM-1] reverse rate constant (Kr): 10.0[s-1]
Calcium_ERCalcium	r45 ER_Membrane	GeneralKinetics	Calcium_ERCalcium
		reaction rate (J): (J0 * Kc * (Calcium_ER - Calcium) * IP3R_open / (Kc + Calcium))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] user defined (J0): 0.8[uM-1.s-1] user defined (Kc): 4.69[uM]
MEKMEK_Ser	028 IC	HMMIrreversible	MEKMEK_Ser
		reaction rate (J): ((Vmax * MEK) / (Km + MEK))[uM.s-1] Km (1/2 max) (Km): 0.15909[uM] max reaction rate (Vmax): (0.3 * Ras_Raf_active)[uM.s-1]
CaMKIICaMKII_286	094 IC	MassAction	CaMKIICaMKII_286
		reaction rate (J): ((Kf * CaMKII) - (Kr * CaMKII_286))[uM.s-1] forward rate constant (Kf): 0.003[s-1] reverse rate constant (Kr): 0.0[s-1]
BDNF_TrkB2BDNF_TrkB2_Pi	003 PM	MassAction	BDNF_TrkB2BDNF_TrkB2_Pi
		reaction rate (J): ((Kf * BDNF_TrkB2) - (Kr * BDNF_TrkB2_Pi))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 0.02[s-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-1]
MEK_SerMEK_active	035 IC	HMMIrreversible	MEK_SerMEK_active
		reaction rate (J): ((Vmax * MEK_Ser) / (Km + MEK_Ser))[uM.s-1] Km (1/2 max) (Km): 0.15909[uM] max reaction rate (Vmax): (Kcat * BRaf_Pi)[uM.s-1] user defined (Kcat): 0.18[s-1]
MEK_activeMEK_Ser	033 IC	HMMIrreversible	MEK_activeMEK_Ser
		reaction rate (J): ((Vmax * MEK_active) / (Km + MEK_active))[uM.s-1] Km (1/2 max) (Km): 15.657[uM] max reaction rate (Vmax): (Kcat * PP2A)[uM.s-1] user defined (Kcat): 6.0[s-1]
MEK_Ser+U0126MEK_inhibited	r14 IC	MassAction	MEK_Ser+U0126MEK_inhibited
		reaction rate (J): (((Kf * MEK_Ser) * U0126) - (Kr * MEK_inhibited))[uM.s-1] forward rate constant (Kf): 1.0[s-1.uM-1] reverse rate constant (Kr): 0.03[s-1]
MEK_active+U0126MEK_inhibited	r15 IC	MassAction	MEK_active+U0126MEK_inhibited
		reaction rate (J): (((Kf * MEK_active) * U0126) - (Kr * MEK_inhibited))[uM.s-1] forward rate constant (Kf): 1.0[s-1.uM-1] reverse rate constant (Kr): 0.03[s-1]
GluR1_845GluR1	108 IC	HMMIrreversible	GluR1_845GluR1
		reaction rate (J): ((Vmax * GluR1_845) / (Km + GluR1_845))[uM.s-1] Km (1/2 max) (Km): 0.97145[uM] max reaction rate (Vmax): (Kcat * PP1)[uM.s-1] user defined (Kcat): 0.17[s-1]
GluR1_845GluR1_845_818	r57 IC	HMMIrreversible	GluR1_845GluR1_845_818
		reaction rate (J): ((Vmax * GluR1_845) / (Km + GluR1_845))[uM.s-1] Km (1/2 max) (Km): 33.0[uM] max reaction rate (Vmax): (Kcat * PKC_active)[uM.s-1] user defined (Kcat): 4.0[s-1]
Rolipram+PDE4_ERKPDE4_Rolipram	r8 IC	MassAction	Rolipram+PDE4_ERKPDE4_Rolipram
		reaction rate (J): (((Kf * Rolipram) * PDE4_ERK) - (Kr * PDE4_Rolipram))[uM.s-1] forward rate constant (Kf): 1.0[s-1.uM-1] reverse rate constant (Kr): 0.019[s-1]
PDE4_ERK_PKA+IBMXPDE4_IBMX	r23 IC	MassAction	PDE4_ERK_PKA+IBMXPDE4_IBMX
		reaction rate (J): (((Kf * PDE4_ERK_PKA) * IBMX) - (Kr * PDE4_IBMX))[uM.s-1] forward rate constant (Kf): 8.0[s-1.uM-1] reverse rate constant (Kr): 0.8[s-1]
Gqby+D1LRD1LR_Gqby	r13 PM	MassAction	Gqby+D1LRD1LR_Gqby
		reaction rate (J): (((Kf * Gqby) * D1LR) - (Kr * D1LR_Gqby))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 0.06[um2.s-1.molecules-1] reverse rate constant (Kr): 3.0E-4[s-1]
I1_PiI1	061 IC	HMMIrreversible	I1_PiI1
		reaction rate (J): ((Vmax * I1_Pi) / (Km + I1_Pi))[uM.s-1] Km (1/2 max) (Km): 16.0[uM] max reaction rate (Vmax): (Kcat * PP2A_DI)[uM.s-1] user defined (Kcat): 2.0[s-1]
Gaby+Da_D1RDa_D1R_Gaby	066 PM	MassAction	Gaby+Da_D1RDa_D1R_Gaby
		reaction rate (J): (((Kf * Gaby) * Da_D1R) - (Kr * Da_D1R_Gaby))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 0.6[um2.s-1.molecules-1] reverse rate constant (Kr): 0.001[s-1]
Ras_GTPRas_GDP	014 IC	MassAction	Ras_GTPRas_GDP
		reaction rate (J): ((Kf * Ras_GTP) - (Kr * Ras_GDP))[uM.s-1] forward rate constant (Kf): 1.0E-4[s-1] reverse rate constant (Kr): 0.0[s-1]
GluR1_MembraneGluR1_Membrane_dephosphorylated1	r17 PM	HMMIrreversible	GluR1_MembraneGluR1_Membrane_dephosphorylated1
		reaction rate (J): ((Vmax * GluR1_Membrane) / (Km + GluR1_Membrane))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] Km (1/2 max) (Km): 0.97145[molecules.um-2] max reaction rate (Vmax): (Kcat * PP1)[molecules.um-2.s-1] user defined (Kcat): 0.17[molecules.um-2.uM-1.s-1]
BRafBRaf_Pi	062 IC	HMMIrreversible	BRafBRaf_Pi
		reaction rate (J): ((Vmax * BRaf) / (Km + BRaf))[uM.s-1] Km (1/2 max) (Km): 7.5[uM] max reaction rate (Vmax): (Kcat * PKA_active)[uM.s-1] user defined (Kcat): 3.0[s-1]
SERCA+CalciumSERCA_active	r42 ER_Membrane	GeneralKinetics	SERCA+CalciumSERCA_active
		reaction rate (J): (SERCA / (1.0 + (2.5 / (Calcium * Calcium)) + (0.25 / Calcium)))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1]
PDE1_CaM_Ca4PDE1	099 IC	MassAction	PDE1_CaM_Ca4PDE1
		reaction rate (J): ((Kf * PDE1_CaM_Ca4) - (Kr * PDE1))[uM.s-1] forward rate constant (Kf): 0.1[s-1] reverse rate constant (Kr): 0.0[s-1]
ATPcAMP	r25 PM	HMMIrreversible	ATPcAMP
		reaction rate (J): ((Vmax * ATP) / (Km + ATP))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] Km (1/2 max) (Km): 315.0[uM] max reaction rate (Vmax): (Kcat * AC5_Fsk)[molecules.um-2.s-1] user defined (Kcat): 8.5[s-1]
R2C2_cAMP4PKA_active+R2C_cAMP4	086 IC	MassAction	R2C2_cAMP4PKA_active+R2C_cAMP4
		reaction rate (J): ((Kf * R2C2_cAMP4) - ((Kr * PKA_active) * R2C_cAMP4))[uM.s-1] forward rate constant (Kf): 60.0[s-1] reverse rate constant (Kr): 18.0[s-1.uM-1]
IP3R+IP3_145IP3R_open	r41 ER_Membrane	MassAction	IP3R+IP3_145IP3R_open
		reaction rate (J): (((Kf * IP3R) * pow(IP3_145,3.0)) - (Kr * IP3R_open))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 1.0[s-1.uM-3] reverse rate constant (Kr): 2.7[s-1]
PDE4_ERKPDE4	048 IC	HMMIrreversible	PDE4_ERKPDE4
		reaction rate (J): ((Vmax * PDE4_ERK) / (Km + PDE4_ERK))[uM.s-1] Km (1/2 max) (Km): 8.0[uM] max reaction rate (Vmax): (Kcat * PP1_PDE)[uM.s-1] user defined (Kcat): 5.0[s-1]
ERK_TyrERK	043 IC	HMMIrreversible	ERK_TyrERK
		reaction rate (J): ((Vmax * ERK_Tyr) / (Km + ERK_Tyr))[uM.s-1] Km (1/2 max) (Km): 0.46[uM] max reaction rate (Vmax): (Kcat * STEP)[uM.s-1] user defined (Kcat): 1.06[s-1]
R2C2_cAMP3+cAMPR2C2_cAMP4	085 IC	MassAction	R2C2_cAMP3+cAMPR2C2_cAMP4
		reaction rate (J): (((Kf * R2C2_cAMP3) * cAMP) - (Kr * R2C2_cAMP4))[uM.s-1] forward rate constant (Kf): 75.0[s-1.uM-1] reverse rate constant (Kr): 32.5[s-1]
CaM_Ca4+CaMKIICaMKII_CaM	092 IC	MassAction	CaM_Ca4+CaMKIICaMKII_CaM
		reaction rate (J): (((Kf * CaM_Ca4) * CaMKII) - (Kr * CaMKII_CaM))[uM.s-1] forward rate constant (Kf): 50.0[s-1.uM-1] reverse rate constant (Kr): 5.0[s-1]
STEP_PKASTEP	041 IC	HMMIrreversible	STEP_PKASTEP
		reaction rate (J): ((Vmax * STEP_PKA) / (Km + STEP_PKA))[uM.s-1] Km (1/2 max) (Km): 6.0[uM] max reaction rate (Vmax): (Kcat * PP1)[uM.s-1] user defined (Kcat): 5.0[s-1]

Structures See in Dashboard
Name	Type Electrical (Membrane Polarity)
IC	Compartment (+) (-)

EC	Compartment (+) (-)

ER	Compartment (+) (-)

PM	Membrane N/A

ER_Membrane	Membrane N/A

Species See in Dashboard
Name	Structure	BioNetGen Definition
BDNF	EC

CaM_Ca4	IC

PDE2_IBMX	IC

Gap	IC

R2C2_cAMP3	IC

SoS_Pi_Grb2	IC

PDE4_ERK_PKA	IC

Gby	PM

R2C2_cAMP	IC

AC5_Ga	PM

D1LR_Gqby	PM

PP1	IC

DARPP32_Pi_PP1	IC

I1_Pi_PP1	IC

PDE4_ERK	IC

AMPAR_Bulk	IC

GluR1_Membrane	PM

Gqby	PM

PLC	PM

PLC_Ca	PM

PLC_Ca_Gq	PM

IP3_degraded	IC

IP3_14	IC

IP3R	ER_Membrane

AC_basal	PM

G_by	PM

Gq_GDP	PM

PKC_active	IC

PP2A	IC

Da_D5R	PM

PP1_PDE	IC

cAMP	IC

Gaby	PM

U0126	IC

DARPP32	IC

Rolipram	IC

Da_D5R_Gaby	PM

AC5	PM

R2C_cAMP4	IC

PDE3_IBMX	IC

R2_cAMP4	IC

BDNF_TrkB	PM

AC5_Fsk	PM

STEP_PKA	IC

BRaf_Pi	IC

D1R_Gaby	PM

Gq_GTP	PM

PDE1_CaM_Ca4	IC

GluR1_845_818	IC

Raf	IC

IBMX	IC

PDEbg	IC

PKA_active	IC

PDE1_IBMX	IC

TrkB	PM

GluR1_degraded	IC

GluR1	IC

MEK_Ser	IC

IP3R_open	ER_Membrane

ERK_Tyr	IC

D1LR	PM

Da	EC

SERCA	ER_Membrane

SERCA_active	ER_Membrane

IP3_5pase1	IC

PLC_Gq	PM

PDE4_PKA	IC

MEK	IC

Ga_GDP	PM

CaM	IC

Fsk	EC

Four1N	IC

PDE4_IBMX	IC

D5R_Gaby	PM

BDNF_TrkB2	PM

I1_Pi	IC

ERK	IC

Ga_GTP	PM

PDE4_Rolipram	IC

PKA_Inhibitor	IC

CaMKII_286_CaM	IC

Ras_GDP	IC

MEK_inhibited	IC

R2C2_cAMP4	IC

Ras_Raf_active	IC

Da_D1R_Gaby	PM

SoS_Grb2	IC

ATP	IC

GluR1_845	IC

IP3_5Pase2	IC

Shc	IC

Ras_GTP	IC

R2C2	IC

D1R	PM

PIP2	PM

Da_D1LR_Gqby	PM

Int_TrkB2	PM

CaMKII	IC

BRaf	IC

R2C2_cAMP2	IC

PDE1	IC

CaM_Ca2	IC

PDE2	IC

BDNF_TrkB2_Pi	IC

ERK_active	IC

Shc_Pi	IC

DAG	PM

IP3_145	IC

MEK_active	IC

AMP	IC

Grb2	IC

STEP	IC

PDE3	IC

Calcium	IC

CaMKII_CaM	IC

SoS	IC

PDE4	IC

CaMKII_286	IC

Da_D1R	PM

SoS_Pi	IC

D5R	PM

PKA_inhibited	IC

CaM_Ca3	IC

Calcium_ER	ER

GluR1_Membrane_dephosphorylated1	PM

I1	IC

Da_D1LR	PM

DARPP32_Pi	IC

Shc_Pi_SoS_Grb2	IC

PP2A_DI	IC

Molecules See in Dashboard
Name	Text Annotations	BioNetGen Definition

Observables See in Dashboard
Name	Type Count	BioNetGen Definition

Applications

Applications See in Dashboard
Name	Math Type	Annotation
Application0	Deterministic (ODE) Compartmental

Application - Application0

Specifications(Species) - Application0 See in Dashboard
Species	Initial Condition	Diffusion Constant
CaM_Ca4	0.0 [uM]	0.0 [um2/s]
PDE2_IBMX	0.0 [uM]	0.0 [um2/s]
Gap	0.01 [uM]	1.0 [um2/s]
R2C2_cAMP3	0.0 [uM]	0.0 [um2/s]
SoS_Pi_Grb2	0.0 [uM]	1.0 [um2/s]
PDE4_ERK_PKA	0.0 [uM]	0.0 [um2/s]
R2C2_cAMP	0.0 [uM]	0.0 [um2/s]
PP1	0.25 [uM]	0.0 [um2/s]
DARPP32_Pi_PP1	0.0 [uM]	0.0 [um2/s]
I1_Pi_PP1	0.0 [uM]	0.0 [um2/s]
PDE4_ERK	0.0 [uM]	0.0 [um2/s]
AMPAR_Bulk	0.011111 [uM]	0.0 [um2/s]
IP3_degraded	0.0 [uM]	0.0 [um2/s]
IP3_14	0.0 [uM]	0.0 [um2/s]
PKC_active	0.05 [uM]	0.0 [um2/s]
PP2A	0.2 [uM]	0.0 [um2/s]
PP1_PDE	0.1 [uM]	0.0 [um2/s]
cAMP	0.0 [uM]	0.0 [um2/s]
U0126	0.0 [uM]	0.0 [um2/s]
DARPP32	0.5 [uM]	0.0 [um2/s]
Rolipram	0.0 [uM]	0.0 [um2/s]
R2C_cAMP4	0.0 [uM]	0.0 [um2/s]
PDE3_IBMX	0.0 [uM]	0.0 [um2/s]
R2_cAMP4	0.0 [uM]	0.0 [um2/s]
STEP_PKA	0.0 [uM]	0.0 [um2/s]
BRaf_Pi	0.0 [uM]	0.0 [um2/s]
PDE1_CaM_Ca4	0.0 [uM]	0.0 [um2/s]
GluR1_845_818	0.0 [uM]	0.0 [um2/s]
Raf	3.0 [uM]	1.0 [um2/s]
IBMX	0.0 [uM]	0.0 [um2/s]
PDEbg	3.0 [uM]	0.0 [um2/s]
PKA_active	0.0 [uM]	0.0 [um2/s]
PDE1_IBMX	0.0 [uM]	0.0 [um2/s]
GluR1_degraded	0.0 [uM]	0.0 [um2/s]
GluR1	0.0 [uM]	0.0 [um2/s]
MEK_Ser	0.0 [uM]	1.0 [um2/s]
ERK_Tyr	0.0 [uM]	1.0 [um2/s]
IP3_5pase1	12.0 [uM]	0.0 [um2/s]
PDE4_PKA	0.0 [uM]	0.0 [um2/s]
MEK	0.18 [uM]	1.0 [um2/s]
CaM	2.0 [uM]	0.0 [um2/s]
Four1N	0.01 [uM]	0.0 [um2/s]
PDE4_IBMX	0.0 [uM]	0.0 [um2/s]
I1_Pi	0.0 [uM]	0.0 [um2/s]
ERK	0.36 [uM]	1.0 [um2/s]
PDE4_Rolipram	0.0 [uM]	0.0 [um2/s]
PKA_Inhibitor	0.25 [uM]	0.0 [um2/s]
CaMKII_286_CaM	0.0 [uM]	0.0 [um2/s]
Ras_GDP	3.0 [uM]	1.0 [um2/s]
MEK_inhibited	0.0 [uM]	0.0 [um2/s]
R2C2_cAMP4	0.0 [uM]	0.0 [um2/s]
Ras_Raf_active	0.0 [uM]	1.0 [um2/s]
SoS_Grb2	0.0 [uM]	1.0 [um2/s]
ATP	2000.0 [uM]	0.0 [um2/s]
GluR1_845	0.0 [uM]	0.0 [um2/s]
IP3_5Pase2	0.463 [uM]	0.0 [um2/s]
Shc	1.0 [uM]	1.0 [um2/s]
Ras_GTP	0.0 [uM]	1.0 [um2/s]
R2C2	0.5 [uM]	0.0 [um2/s]
CaMKII	2.0 [uM]	0.0 [um2/s]
BRaf	0.18 [uM]	0.0 [um2/s]
R2C2_cAMP2	0.0 [uM]	0.0 [um2/s]
PDE1	1.0 [uM]	0.0 [um2/s]
CaM_Ca2	0.0 [uM]	0.0 [um2/s]
PDE2	1.0 [uM]	0.0 [um2/s]
BDNF_TrkB2_Pi	0.0 [uM]	0.0 [um2/s]
ERK_active	0.0 [uM]	1.0 [um2/s]
Shc_Pi	0.0 [uM]	1.0 [um2/s]
IP3_145	0.0 [uM]	0.0 [um2/s]
MEK_active	0.0 [uM]	1.0 [um2/s]
AMP	0.0 [uM]	0.0 [um2/s]
Grb2	1.0 [uM]	1.0 [um2/s]
STEP	0.2 [uM]	0.0 [um2/s]
PDE3	0.005 [uM]	0.0 [um2/s]
Calcium	0.08 [uM]	0.0 [um2/s]
CaMKII_CaM	0.0 [uM]	0.0 [um2/s]
SoS	1.0 [uM]	1.0 [um2/s]
PDE4	0.4 [uM]	0.0 [um2/s]
CaMKII_286	0.0 [uM]	0.0 [um2/s]
SoS_Pi	0.0 [uM]	1.0 [um2/s]
PKA_inhibited	0.0 [uM]	0.0 [um2/s]
CaM_Ca3	0.0 [uM]	0.0 [um2/s]
I1	0.68 [uM]	0.0 [um2/s]
DARPP32_Pi	0.0 [uM]	0.0 [um2/s]
Shc_Pi_SoS_Grb2	0.0 [uM]	1.0 [um2/s]
PP2A_DI	0.11111 [uM]	0.0 [um2/s]
BDNF	0.0 [uM]	1.0 [um2/s]
Da	0.0 [uM]	0.0 [um2/s]
Fsk	0.0 [uM]	0.0 [um2/s]
Calcium_ER	900.0 [uM]	0.0 [um2/s]
Gby	0.0 [uM]	0.0 [um2/s]
AC5_Ga	0.0 [uM]	0.0 [um2/s]
D1LR_Gqby	0.0 [uM]	0.0 [um2/s]
GluR1_Membrane	0.0 [uM]	0.0 [um2/s]
Gqby	20.0 [uM]	0.0 [um2/s]
PLC	20.0 [uM]	0.0 [um2/s]
PLC_Ca	0.0 [uM]	0.0 [um2/s]
PLC_Ca_Gq	0.0 [uM]	0.0 [um2/s]
AC_basal	11.8 [uM]	0.0 [um2/s]
G_by	0.0 [uM]	0.0 [um2/s]
Gq_GDP	0.0 [uM]	0.0 [um2/s]
Da_D5R	0.0 [uM]	0.0 [um2/s]
Gaby	100.0 [uM]	0.0 [um2/s]
Da_D5R_Gaby	0.0 [uM]	0.0 [um2/s]
AC5	45.0 [uM]	0.0 [um2/s]
BDNF_TrkB	0.0 [uM]	0.0 [um2/s]
AC5_Fsk	0.0 [uM]	0.0 [um2/s]
D1R_Gaby	0.0 [uM]	0.0 [um2/s]
Gq_GTP	0.0 [uM]	0.0 [um2/s]
TrkB	200.0 [uM]	0.0 [um2/s]
D1LR	20.0 [uM]	0.0 [um2/s]
PLC_Gq	0.0 [uM]	0.0 [um2/s]
Ga_GDP	0.0 [uM]	0.0 [um2/s]
D5R_Gaby	0.0 [uM]	0.0 [um2/s]
BDNF_TrkB2	0.0 [uM]	0.0 [um2/s]
Ga_GTP	0.0 [uM]	0.0 [um2/s]
Da_D1R_Gaby	0.0 [uM]	0.0 [um2/s]
D1R	100.0 [uM]	0.0 [um2/s]
PIP2	100.0 [uM]	0.0 [um2/s]
Da_D1LR_Gqby	0.0 [uM]	0.0 [um2/s]
Int_TrkB2	0.0 [uM]	0.0 [um2/s]
DAG	0.0 [uM]	0.0 [um2/s]
Da_D1R	0.0 [uM]	0.0 [um2/s]
D5R	10.0 [uM]	0.0 [um2/s]
GluR1_Membrane_dephosphorylated1	0.0 [uM]	0.0 [um2/s]
Da_D1LR	0.0 [uM]	0.0 [um2/s]
IP3R	100.0 [uM]	0.0 [um2/s]
IP3R_open	0.0 [uM]	0.0 [um2/s]
SERCA	250.0 [uM]	0.0 [um2/s]
SERCA_active	0.0 [uM]	0.0 [um2/s]

Specifications(Reaction) - Application0 See in Dashboard
Name	Reaction Mapping
091	included
005	included
r44	included
r19	included
r20	included
r40	included
057	included
r28	included
087	included
r10	included
r7	included
r21	included
096	included
056	included
036	included
064	included
r52	included
078	included
103	included
073	included
r38	included
r12	included
r6	included
100	included
r0	included
r11	included
r3	included
r55	included
011	included
012	included
097	included
071	included
002	included
r35	included
023	included
001	included
r36	included
084	included
098	included
r26	included
081	included
104	included
077	included
032	included
008	included
006	included
r27	included
046	included
060	included
018	included
r48	included
045	included
075	included
009	included
r50	included
004	included
r56	included
r37	included
r32	included
007	included
106	included
r29	included
067	included
088	included
r24	included
r31	included
r22	included
r34	included
010	included
r18	included
r1	included
r49	included
105	included
034	included
063	included
r47	included
095	included
065	included
r51	included
029	included
089	included
r43	included
r53	included
r33	included
082	included
040	included
r9	included
052	included
070	included
r30	included
069	included
079	included
r4	included
037	included
016	included
074	included
093	included
r54	included
080	included
072	included
049	included
r16	included
r39	included
068	included
047	included
r5	included
044	included
083	included
090	included
r45	included
028	included
094	included
003	included
035	included
033	included
r14	included
r15	included
108	included
r57	included
r8	included
r23	included
r13	included
061	included
066	included
014	included
r17	included
062	included
r42	included
099	included
r25	included
086	included
r41	included
048	included
043	included
085	included
092	included
041	included

Simulations - Application0 See in Dashboard
Name	End Time	Output Options
DA0.1	6000.0 [s]	OutputTimeStep 60.0
DA0.1+U0126	5400.0 [s]	OutputTimeStep 60.0
DA0.1+Rolipram	5400.0 [s]	OutputTimeStep 60.0
DA0.1+BDNF	5400.0 [s]	OutputTimeStep 60.0
DA1.0	6000.0 [s]	OutputTimeStep 60.0
DA1.0+U0126	5400.0 [s]	OutputTimeStep 60.0
DA1.0+Rolipram	5400.0 [s]	OutputTimeStep 60.0
DA1.0+BDNF	5400.0 [s]	OutputTimeStep 60.0

Events - Application0 See in Dashboard
Name	Trigger Type	Variable Assignment
t3600	on condition: 3600.0	Da --> 0.1, U0126 --> 0.0, Rolipram --> 0.0, BDNF --> 0.0
t5400	on condition: 5400.0	IBMX --> 10.0, Fsk --> 10.0

Geometry non-spatial1634669173 See in Dashboard
(Origin: 0.0, 0.0, 0.0; Extent: 10.0, 10.0, 10.0[um])
Dimension	Type	Subdomain	Adjacent Subvolumes	Size	Mapped Compartment
	Compartmental	Compartment			ER_Membrane

Global Parameters

Global Parameters See in Dashboard
Name	Expression