Physiology

Reaction Diagram

reactionDiagram

Cross-References

Annotations

Reactions

Reactions
Name
Structure
Kinetics
Depiction
CaM_Ca3+CalciumCaM_Ca4 091 IC MassAction
Int_TrkB2TrkB 005 PM MassAction
CalciumCalcium_ER r44 ER_Membrane GeneralKinetics
PDE1+IBMXPDE1_IBMX r19 IC MassAction
Da+D1LR_GqbyDa_D1LR_Gqby r20 PM MassAction
IP3_145IP3_14 r40 IC HMMIrreversible
DARPP32_PiDARPP32 057 IC HMMIrreversible
Da_D1LR_GqbyG_by+Da_D1LR+Gq_GTP r28 PM MassAction
R2C_cAMP4PKA_active+R2_cAMP4 087 IC MassAction
Rolipram+PDE4_ERK_PKAPDE4_Rolipram r10 IC MassAction
AC5+FskAC5_Fsk r7 PM MassAction
IBMX+PDE4PDE4_IBMX r21 IC MassAction
CaMKII_286CaMKII 096 IC HMMIrreversible
DARPP32DARPP32_Pi 056 IC HMMIrreversible
ERKERK_Tyr 036 IC HMMIrreversible
Da+D1RDa_D1R 064 PM MassAction
cAMPAMP r52 IC HMMIrreversible
cAMPAMP 078 IC HMMIrreversible
Four1N+GluR1_845_818GluR1_Membrane 103 PM MassAction
Ga_GDP+GbyGaby 073 PM MassAction
IP3_145IP3_degraded r38 IC MassAction
cAMPAMP r12 IC HMMIrreversible
PDE3+IBMXPDE3_IBMX r6 IC MassAction
AMPAR_BulkGluR1 100 IC MassAction
Da_D5R_GabyDa_D5R+Gby+Ga_GTP r0 PM MassAction
Rolipram+PDE4_PKAPDE4_Rolipram r11 IC MassAction
ATPcAMP r3 PM HMMIrreversible
PDE4_ERK_PKAPDE4 r55 IC HMMIrreversible
ShcShc_Pi 011 IC HMMIrreversible
SoSSoS_Pi 012 IC HMMIrreversible
CaMKII_286_CaMCaMKII_CaM 097 IC HMMIrreversible
Da_D5R+GabyDa_D5R_Gaby 071 PM MassAction
TrkB+BDNF_TrkBBDNF_TrkB2 002 PM MassAction
PLC+CalciumPLC_Ca r35 PM MassAction
Ras_GTPRas_GDP 023 IC HMMIrreversible
BDNF+TrkBBDNF_TrkB 001 PM MassAction
PLC_GqGq_GDP+PLC r36 PM MassAction
R2C2_cAMP2+cAMPR2C2_cAMP3 084 IC MassAction
PDE1+CaM_Ca4PDE1_CaM_Ca4 098 IC MassAction
Da+D1LRDa_D1LR r26 PM MassAction
cAMPAMP 081 IC HMMIrreversible
GluR1_Membrane_dephosphorylated1GluR1+Four1N 104 PM MassAction
cAMPAMP 077 IC HMMIrreversible
MEK_SerMEK 032 IC HMMIrreversible
SoS_Pi+Grb2SoS_Pi_Grb2 008 IC MassAction
Shc_PiShc 006 IC MassAction
Da_D1LR+GqbyDa_D1LR_Gqby r27 PM MassAction
PDE4_PKAPDE4 046 IC HMMIrreversible
I1I1_Pi 060 IC HMMIrreversible
Ras_GDPRas_GTP 018 IC HMMIrreversible
cAMPAMP r48 IC HMMIrreversible
PDE4PDE4_PKA 045 IC HMMIrreversible
Ga_GTP+AC5AC5_Ga 075 PM MassAction
SoS_PiSoS 009 IC MassAction
cAMPAMP r50 IC HMMIrreversible
BDNF_TrkB2_PiInt_TrkB2 004 PM MassAction
GluR1_845_818GluR1_845 r56 IC HMMIrreversible
PLC_Gq+CalciumPLC_Ca_Gq r37 PM MassAction
PIP2DAG+IP3_145 r32 PM HMMIrreversible
SoS_Grb2+Shc_PiShc_Pi_SoS_Grb2 007 IC MassAction
GluR1GluR1_845 106 IC HMMIrreversible
Gq_GDP+G_byGqby r29 PM MassAction
D1R_Gaby+DaDa_D1R_Gaby 067 PM MassAction
PKA_active+PKA_InhibitorPKA_inhibited 088 IC MassAction
PDE4_ERK+IBMXPDE4_IBMX r24 IC MassAction
PIP2IP3_145+DAG r31 PM HMMIrreversible
PDE4_PKA+IBMXPDE4_IBMX r22 IC MassAction
PLC+Gq_GTPPLC_Gq r34 PM MassAction
Grb2+SoSSoS_Grb2 010 IC MassAction
DARPP32_Pi+PP1DARPP32_Pi_PP1 r18 IC MassAction
ATPcAMP r1 PM HMMIrreversible
ERK_activeERK_Tyr r49 IC HMMIrreversible
GluR1_MembraneGluR1_degraded 105 PM MassAction
MEKMEK_Ser 034 IC HMMIrreversible
BRaf_PiBRaf 063 IC HMMIrreversible
DARPP32_Pi_PP1PP1+DARPP32 r47 IC MassAction
CaMKII_CaMCaMKII_286_CaM 095 IC HMMIrreversible
Gaby+D1RD1R_Gaby 065 PM MassAction
PDE2+IBMXPDE2_IBMX r51 IC MassAction
MEK_SerMEK_active 029 IC HMMIrreversible
CaM+CalciumCaM_Ca2 089 IC MassAction
Calcium_ERCalcium r43 ER_Membrane MassAction
I1_Pi+PP1I1_Pi_PP1 r53 IC MassAction
PIP2DAG+IP3_145 r33 PM HMMIrreversible
R2C2+cAMPR2C2_cAMP 082 IC MassAction
STEPSTEP_PKA 040 IC HMMIrreversible
PDE4+RolipramPDE4_Rolipram r9 IC MassAction
PDE4_ERKPDE4_ERK_PKA 052 IC HMMIrreversible
Da+D5R_GabyDa_D5R_Gaby 070 PM MassAction
Gq_GTPGq_GDP r30 PM MassAction
Gaby+D5RD5R_Gaby 069 PM MassAction
cAMPAMP 079 IC HMMIrreversible
ATPcAMP r4 PM HMMIrreversible
ERK_TyrERK_active 037 IC HMMIrreversible
Ras_GTP+RafRas_Raf_active 016 IC MassAction
Ga_GTPGa_GDP 074 PM MassAction
CaMKII_286+CaM_Ca4CaMKII_286_CaM 093 IC MassAction
I1_Pi_PP1PP1+I1 r54 IC MassAction
cAMPAMP 080 IC HMMIrreversible
Da_D1R_GabyGby+Ga_GTP+Da_D1R 072 PM MassAction
PDE4_PKAPDE4_ERK_PKA 049 IC HMMIrreversible
MEK+U0126MEK_inhibited r16 IC MassAction
IP3_145IP3_14 r39 IC HMMIrreversible
D5R+DaDa_D5R 068 PM MassAction
PDE4PDE4_ERK 047 IC HMMIrreversible
PDE1_CaM_Ca4+IBMXPDE1_IBMX r5 IC MassAction
ERK_TyrERK 044 IC HMMIrreversible
cAMP+R2C2_cAMPR2C2_cAMP2 083 IC MassAction
CaM_Ca2+CalciumCaM_Ca3 090 IC MassAction
Calcium_ERCalcium r45 ER_Membrane GeneralKinetics
MEKMEK_Ser 028 IC HMMIrreversible
CaMKIICaMKII_286 094 IC MassAction
BDNF_TrkB2BDNF_TrkB2_Pi 003 PM MassAction
MEK_SerMEK_active 035 IC HMMIrreversible
MEK_activeMEK_Ser 033 IC HMMIrreversible
MEK_Ser+U0126MEK_inhibited r14 IC MassAction
MEK_active+U0126MEK_inhibited r15 IC MassAction
GluR1_845GluR1 108 IC HMMIrreversible
GluR1_845GluR1_845_818 r57 IC HMMIrreversible
Rolipram+PDE4_ERKPDE4_Rolipram r8 IC MassAction
PDE4_ERK_PKA+IBMXPDE4_IBMX r23 IC MassAction
Gqby+D1LRD1LR_Gqby r13 PM MassAction
I1_PiI1 061 IC HMMIrreversible
Gaby+Da_D1RDa_D1R_Gaby 066 PM MassAction
Ras_GTPRas_GDP 014 IC MassAction
GluR1_MembraneGluR1_Membrane_dephosphorylated1 r17 PM HMMIrreversible
BRafBRaf_Pi 062 IC HMMIrreversible
SERCA+CalciumSERCA_active r42 ER_Membrane GeneralKinetics
PDE1_CaM_Ca4PDE1 099 IC MassAction
ATPcAMP r25 PM HMMIrreversible
R2C2_cAMP4PKA_active+R2C_cAMP4 086 IC MassAction
IP3R+IP3_145IP3R_open r41 ER_Membrane MassAction
PDE4_ERKPDE4 048 IC HMMIrreversible
ERK_TyrERK 043 IC HMMIrreversible
R2C2_cAMP3+cAMPR2C2_cAMP4 085 IC MassAction
CaM_Ca4+CaMKIICaMKII_CaM 092 IC MassAction
STEP_PKASTEP 041 IC HMMIrreversible

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Expressions for 091

reaction rate

J

(((Kf * CaM_Ca3) * Calcium) - (Kr * CaM_Ca4)) [uM.s-1]

forward rate constant

Kf

0.465 [s-1.uM-1]

reverse rate constant

Kr

10.0 [s-1]

Expressions for 005

reaction rate

J

((Kf * Int_TrkB2) - (Kr * TrkB)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

forward rate constant

Kf

0.001 [s-1]

reverse rate constant

Kr

0.001 [s-1]

Expressions for r44

reaction rate

J

(Kcat * SERCA_active * Calcium * Calcium / (0.0625 + (Calcium * Calcium))) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

local

Kcat

10.0 [s-1]

Expressions for r19

reaction rate

J

(((Kf * PDE1) * IBMX) - (Kr * PDE1_IBMX)) [uM.s-1]

forward rate constant

Kf

8.0 [s-1.uM-1]

reverse rate constant

Kr

0.8 [s-1]

Expressions for r20

reaction rate

J

(((Kf * Da) * D1LR_Gqby) - (Kr * Da_D1LR_Gqby)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

forward rate constant

Kf

3.33 [s-1.uM-1]

reverse rate constant

Kr

10.0 [s-1]

Expressions for r40

reaction rate

J

((Vmax * IP3_145) / (Km + IP3_145)) [uM.s-1]

Km (1/2 max)

Km

18.0 [uM]

max reaction rate

Vmax

(Kcat * IP3_5Pase2) [uM.s-1]

local

Kcat

10.667 [s-1]

Expressions for 057

reaction rate

J

((Vmax * DARPP32_Pi) / (Km + DARPP32_Pi)) [uM.s-1]

Km (1/2 max)

Km

0.37 [uM]

max reaction rate

Vmax

(Kcat * PP2A_DI) [uM.s-1]

local

Kcat

6.7 [s-1]

Expressions for r28

reaction rate

J

((Kf * Da_D1LR_Gqby) - (((Kr * G_by) * Da_D1LR) * Gq_GTP)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

forward rate constant

Kf

20.0 [s-1]

reverse rate constant

Kr

0.0 [um4.s-1.molecules-2]

Expressions for 087

reaction rate

J

((Kf * R2C_cAMP4) - ((Kr * PKA_active) * R2_cAMP4)) [uM.s-1]

forward rate constant

Kf

60.0 [s-1]

reverse rate constant

Kr

18.0 [s-1.uM-1]

Expressions for r10

reaction rate

J

(((Kf * Rolipram) * PDE4_ERK_PKA) - (Kr * PDE4_Rolipram)) [uM.s-1]

forward rate constant

Kf

1.0 [s-1.uM-1]

reverse rate constant

Kr

0.019 [s-1]

Expressions for r7

reaction rate

J

(((Kf * AC5) * Fsk) - (Kr * AC5_Fsk)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

forward rate constant

Kf

0.026 [s-1.uM-1]

reverse rate constant

Kr

1.0 [s-1]

Expressions for r21

reaction rate

J

(((Kf * IBMX) * PDE4) - (Kr * PDE4_IBMX)) [uM.s-1]

forward rate constant

Kf

8.0 [s-1.uM-1]

reverse rate constant

Kr

0.8 [s-1]

Expressions for 096

reaction rate

J

((Vmax * CaMKII_286) / (Km + CaMKII_286)) [uM.s-1]

Km (1/2 max)

Km

5.1 [uM]

max reaction rate

Vmax

(Kcat * PP1) [uM.s-1]

local

Kcat

0.35 [s-1]

Expressions for 056

reaction rate

J

((Vmax * DARPP32) / (Km + DARPP32)) [uM.s-1]

Km (1/2 max)

Km

2.4 [uM]

max reaction rate

Vmax

(Kcat * PKA_active) [uM.s-1]

local

Kcat

2.7 [s-1]

Expressions for 036

reaction rate

J

((Vmax * ERK) / (Km + ERK)) [uM.s-1]

Km (1/2 max)

Km

0.046296 [uM]

max reaction rate

Vmax

(Kcat * MEK_active) [uM.s-1]

local

Kcat

0.15 [s-1]

Expressions for 064

reaction rate

J

(((Kf * Da) * D1R) - (Kr * Da_D1R)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

forward rate constant

Kf

1.11 [s-1.uM-1]

reverse rate constant

Kr

10.0 [s-1]

Expressions for r52

reaction rate

J

((Vmax * cAMP) / (Km + cAMP)) [uM.s-1]

Km (1/2 max)

Km

90.0 [uM]

max reaction rate

Vmax

(Kcat * PDEbg) [uM.s-1]

local

Kcat

20.0 [s-1]

Expressions for 078

reaction rate

J

((Vmax * cAMP) / (Km + cAMP)) [uM.s-1]

Km (1/2 max)

Km

1.8 [uM]

max reaction rate

Vmax

(Kcat * PDE4_ERK_PKA) [uM.s-1]

local

Kcat

8.0 [s-1]

Expressions for 103

reaction rate

J

(((Kf * Four1N) * GluR1_845_818) - (Kr * GluR1_Membrane)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

forward rate constant

Kf

0.0108 [molecules.um-2.s-1.uM-2]

reverse rate constant

Kr

0.008 [s-1]

Expressions for 073

reaction rate

J

(((Kf * Ga_GDP) * Gby) - (Kr * Gaby)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

forward rate constant

Kf

100.0 [um2.s-1.molecules-1]

reverse rate constant

Kr

0.0 [s-1]

Expressions for r38

reaction rate

J

((Kf * IP3_145) - (Kr * IP3_degraded)) [uM.s-1]

forward rate constant

Kf

2.5 [s-1]

reverse rate constant

Kr

0.0 [s-1]

Expressions for r12

reaction rate

J

((Vmax * cAMP) / (Km + cAMP)) [uM.s-1]

Km (1/2 max)

Km

0.3 [uM]

max reaction rate

Vmax

(Kcat * PDE3) [uM.s-1]

local

Kcat

30.0 [s-1]

Expressions for r6

reaction rate

J

(((Kf * PDE3) * IBMX) - (Kr * PDE3_IBMX)) [uM.s-1]

forward rate constant

Kf

8.0 [s-1.uM-1]

reverse rate constant

Kr

0.8 [s-1]

Expressions for 100

reaction rate

J

((Kf * AMPAR_Bulk) - (Kr * GluR1)) [uM.s-1]

forward rate constant

Kf

0.018 [s-1]

reverse rate constant

Kr

1.0 [s-1]

Expressions for r0

reaction rate

J

((Kf * Da_D5R_Gaby) - (((Kr * Da_D5R) * Gby) * Ga_GTP)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

forward rate constant

Kf

20.0 [s-1]

reverse rate constant

Kr

0.0 [um4.s-1.molecules-2]

Expressions for r11

reaction rate

J

(((Kf * Rolipram) * PDE4_PKA) - (Kr * PDE4_Rolipram)) [uM.s-1]

forward rate constant

Kf

1.0 [s-1.uM-1]

reverse rate constant

Kr

0.019 [s-1]

Expressions for r3

reaction rate

J

((Vmax * ATP) / (Km + ATP)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

Km (1/2 max)

Km

20.1149 [uM]

max reaction rate

Vmax

(Kcat * AC_basal) [molecules.um-2.s-1]

local

Kcat

7.0 [s-1]

Expressions for r55

reaction rate

J

((Vmax * PDE4_ERK_PKA) / (Km + PDE4_ERK_PKA)) [uM.s-1]

Km (1/2 max)

Km

8.0 [uM]

max reaction rate

Vmax

(Kcat * PP1_PDE) [uM.s-1]

local

Kcat

1.0 [s-1]

Expressions for 011

reaction rate

J

((Vmax * Shc) / (Km + Shc)) [uM.s-1]

Km (1/2 max)

Km

0.83331 [uM]

max reaction rate

Vmax

(0.3 * BDNF_TrkB2_Pi) [uM.s-1]

Expressions for 012

reaction rate

J

((Vmax * SoS) / (Km + SoS)) [uM.s-1]

Km (1/2 max)

Km

25.641 [uM]

max reaction rate

Vmax

(10.0 * ERK_active) [uM.s-1]

Expressions for 097

reaction rate

J

((Vmax * CaMKII_286_CaM) / (Km + CaMKII_286_CaM)) [uM.s-1]

Km (1/2 max)

Km

5.1 [uM]

max reaction rate

Vmax

(Kcat * PP1) [uM.s-1]

local

Kcat

0.35 [s-1]

Expressions for 071

reaction rate

J

(((Kf * Da_D5R) * Gaby) - (Kr * Da_D5R_Gaby)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

forward rate constant

Kf

0.6 [um2.s-1.molecules-1]

reverse rate constant

Kr

0.001 [s-1]

Expressions for 002

reaction rate

J

(((Kf * TrkB) * BDNF_TrkB) - (Kr * BDNF_TrkB2)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

forward rate constant

Kf

1.0 [um2.s-1.molecules-1]

reverse rate constant

Kr

0.02 [s-1]

Expressions for r35

reaction rate

J

(((Kf * PLC) * Calcium) - (Kr * PLC_Ca)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

forward rate constant

Kf

1.0 [s-1.uM-1]

reverse rate constant

Kr

1.0 [s-1]

Expressions for 023

reaction rate

J

((Vmax * Ras_GTP) / (Km + Ras_GTP)) [uM.s-1]

Km (1/2 max)

Km

1.0104 [uM]

max reaction rate

Vmax

(10.0 * Gap) [uM.s-1]

Expressions for 001

reaction rate

J

(((Kf * BDNF) * TrkB) - (Kr * BDNF_TrkB)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

forward rate constant

Kf

1.0 [s-1.uM-1]

reverse rate constant

Kr

0.05 [s-1]

Expressions for r36

reaction rate

J

((Kf * PLC_Gq) - ((Kr * Gq_GDP) * PLC)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

forward rate constant

Kf

0.094 [s-1]

reverse rate constant

Kr

0.0 [um2.s-1.molecules-1]

Expressions for 084

reaction rate

J

(((Kf * R2C2_cAMP2) * cAMP) - (Kr * R2C2_cAMP3)) [uM.s-1]

forward rate constant

Kf

75.0 [s-1.uM-1]

reverse rate constant

Kr

110.0 [s-1]

Expressions for 098

reaction rate

J

(((Kf * PDE1) * CaM_Ca4) - (Kr * PDE1_CaM_Ca4)) [uM.s-1]

forward rate constant

Kf

0.1 [s-1.uM-1]

reverse rate constant

Kr

1.0 [s-1]

Expressions for r26

reaction rate

J

(((Kf * Da) * D1LR) - (Kr * Da_D1LR)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

forward rate constant

Kf

1.11 [s-1.uM-1]

reverse rate constant

Kr

10.0 [s-1]

Expressions for 081

reaction rate

J

((Vmax * cAMP) / (Km + cAMP)) [uM.s-1]

Km (1/2 max)

Km

39.683 [uM]

max reaction rate

Vmax

(Kcat * PDE1_CaM_Ca4) [uM.s-1]

local

Kcat

10.0 [s-1]

Expressions for 104

reaction rate

J

((Kf * GluR1_Membrane_dephosphorylated1) - ((Kr * GluR1) * Four1N)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

forward rate constant

Kf

8.0E-4 [s-1]

reverse rate constant

Kr

0.0 [molecules.um-2.s-1.uM-2]

Expressions for 077

reaction rate

J

((Vmax * cAMP) / (Km + cAMP)) [uM.s-1]

Km (1/2 max)

Km

1.8 [uM]

max reaction rate

Vmax

(Kcat * PDE4) [uM.s-1]

local

Kcat

10.0 [s-1]

Expressions for 032

reaction rate

J

((Vmax * MEK_Ser) / (Km + MEK_Ser)) [uM.s-1]

Km (1/2 max)

Km

15.657 [uM]

max reaction rate

Vmax

(Kcat * PP2A) [uM.s-1]

local

Kcat

6.0 [s-1]

Expressions for 008

reaction rate

J

(((Kf * SoS_Pi) * Grb2) - (Kr * SoS_Pi_Grb2)) [uM.s-1]

forward rate constant

Kf

0.025 [s-1.uM-1]

reverse rate constant

Kr

0.0168 [s-1]

Expressions for 006

reaction rate

J

((Kf * Shc_Pi) - (Kr * Shc)) [uM.s-1]

forward rate constant

Kf

1.0E-4 [s-1]

reverse rate constant

Kr

0.0 [s-1]

Expressions for r27

reaction rate

J

(((Kf * Da_D1LR) * Gqby) - (Kr * Da_D1LR_Gqby)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

forward rate constant

Kf

0.6 [um2.s-1.molecules-1]

reverse rate constant

Kr

0.001 [s-1]

Expressions for 046

reaction rate

J

((Vmax * PDE4_PKA) / (Km + PDE4_PKA)) [uM.s-1]

Km (1/2 max)

Km

8.0 [uM]

max reaction rate

Vmax

(Kcat * PP1_PDE) [uM.s-1]

local

Kcat

5.0 [s-1]

Expressions for 060

reaction rate

J

((Vmax * I1) / (Km + I1)) [uM.s-1]

Km (1/2 max)

Km

7.5 [uM]

max reaction rate

Vmax

(Kcat * PKA_active) [uM.s-1]

local

Kcat

6.0 [s-1]

Expressions for 018

reaction rate

J

((Vmax * Ras_GDP) / (Km + Ras_GDP)) [uM.s-1]

Km (1/2 max)

Km

0.50505 [uM]

max reaction rate

Vmax

(0.2 * Shc_Pi_SoS_Grb2) [uM.s-1]

Expressions for r48

reaction rate

J

((Vmax * cAMP) / (Km + cAMP)) [uM.s-1]

Km (1/2 max)

Km

1.8 [uM]

max reaction rate

Vmax

(Kcat * PDE4_ERK) [uM.s-1]

local

Kcat

0.01 [s-1]

Expressions for 045

reaction rate

J

((Vmax * PDE4) / (Km + PDE4)) [uM.s-1]

Km (1/2 max)

Km

7.5 [uM]

max reaction rate

Vmax

(Kcat * PKA_active) [uM.s-1]

local

Kcat

3.0 [s-1]

Expressions for 075

reaction rate

J

(((Kf * Ga_GTP) * AC5) - (Kr * AC5_Ga)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

forward rate constant

Kf

38.5 [um2.s-1.molecules-1]

reverse rate constant

Kr

50.0 [s-1]

Expressions for 009

reaction rate

J

((Kf * SoS_Pi) - (Kr * SoS)) [uM.s-1]

forward rate constant

Kf

0.001 [s-1]

reverse rate constant

Kr

0.0 [s-1]

Expressions for r50

reaction rate

J

((Vmax * cAMP) / (Km + cAMP)) [uM.s-1]

Km (1/2 max)

Km

30.0 [uM]

max reaction rate

Vmax

(Kcat * PDE2) [uM.s-1]

local

Kcat

12.0 [s-1]

Expressions for 004

reaction rate

J

((Kf * BDNF_TrkB2_Pi) - (Kr * Int_TrkB2)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

forward rate constant

Kf

1.0E-4 [molecules.um-2.s-1.uM-1]

reverse rate constant

Kr

0.0 [s-1]

Expressions for r56

reaction rate

J

((Vmax * GluR1_845_818) / (Km + GluR1_845_818)) [uM.s-1]

Km (1/2 max)

Km

0.97145 [uM]

max reaction rate

Vmax

(Kcat * PP1) [uM.s-1]

local

Kcat

0.17 [s-1]

Expressions for r37

reaction rate

J

(((Kf * PLC_Gq) * Calcium) - (Kr * PLC_Ca_Gq)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

forward rate constant

Kf

30.0 [s-1.uM-1]

reverse rate constant

Kr

1.0 [s-1]

Expressions for r32

reaction rate

J

((Vmax * PIP2) / (Km + PIP2)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

Km (1/2 max)

Km

5.0 [molecules.um-2]

max reaction rate

Vmax

(Kcat * PLC_Ca_Gq) [molecules.um-2.s-1]

local

Kcat

48.0 [s-1]

Expressions for 007

reaction rate

J

(((Kf * SoS_Grb2) * Shc_Pi) - (Kr * Shc_Pi_SoS_Grb2)) [uM.s-1]

forward rate constant

Kf

0.5 [s-1.uM-1]

reverse rate constant

Kr

0.1 [s-1]

Expressions for 106

reaction rate

J

((Vmax * GluR1) / (Km + GluR1)) [uM.s-1]

Km (1/2 max)

Km

7.5002 [uM]

max reaction rate

Vmax

(Kcat * PKA_active) [uM.s-1]

local

Kcat

6.0 [s-1]

Expressions for r29

reaction rate

J

(((Kf * Gq_GDP) * G_by) - (Kr * Gqby)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

forward rate constant

Kf

100.0 [um2.s-1.molecules-1]

reverse rate constant

Kr

0.0 [s-1]

Expressions for 067

reaction rate

J

(((Kf * D1R_Gaby) * Da) - (Kr * Da_D1R_Gaby)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

forward rate constant

Kf

3.33 [s-1.uM-1]

reverse rate constant

Kr

10.0 [s-1]

Expressions for 088

reaction rate

J

(((Kf * PKA_active) * PKA_Inhibitor) - (Kr * PKA_inhibited)) [uM.s-1]

forward rate constant

Kf

60.0 [s-1.uM-1]

reverse rate constant

Kr

1.0 [s-1]

Expressions for r24

reaction rate

J

(((Kf * PDE4_ERK) * IBMX) - (Kr * PDE4_IBMX)) [uM.s-1]

forward rate constant

Kf

8.0 [s-1.uM-1]

reverse rate constant

Kr

0.8 [s-1]

Expressions for r31

reaction rate

J

((Vmax * PIP2) / (Km + PIP2)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

Km (1/2 max)

Km

5.0 [molecules.um-2]

max reaction rate

Vmax

(Kcat * PLC_Gq) [molecules.um-2.s-1]

local

Kcat

75.0 [s-1]

Expressions for r22

reaction rate

J

(((Kf * PDE4_PKA) * IBMX) - (Kr * PDE4_IBMX)) [uM.s-1]

forward rate constant

Kf

8.0 [s-1.uM-1]

reverse rate constant

Kr

0.8 [s-1]

Expressions for r34

reaction rate

J

(((Kf * PLC) * Gq_GTP) - (Kr * PLC_Gq)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

forward rate constant

Kf

0.25 [um2.s-1.molecules-1]

reverse rate constant

Kr

0.003 [s-1]

Expressions for 010

reaction rate

J

(((Kf * Grb2) * SoS) - (Kr * SoS_Grb2)) [uM.s-1]

forward rate constant

Kf

0.025 [s-1.uM-1]

reverse rate constant

Kr

0.0168 [s-1]

Expressions for r18

reaction rate

J

(((Kf * DARPP32_Pi) * PP1) - (Kr * DARPP32_Pi_PP1)) [uM.s-1]

forward rate constant

Kf

100.0 [s-1.uM-1]

reverse rate constant

Kr

0.2 [s-1]

Expressions for r1

reaction rate

J

((Vmax * ATP) / (Km + ATP)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

Km (1/2 max)

Km

315.0 [uM]

max reaction rate

Vmax

(Kcat * AC5_Ga) [molecules.um-2.s-1]

local

Kcat

8.5 [s-1]

Expressions for r49

reaction rate

J

((Vmax * ERK_active) / (Km + ERK_active)) [uM.s-1]

Km (1/2 max)

Km

0.77 [uM]

max reaction rate

Vmax

(Kcat * PP2A) [uM.s-1]

local

Kcat

0.636 [s-1]

Expressions for 105

reaction rate

J

((Kf * GluR1_Membrane) - (Kr * GluR1_degraded)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

forward rate constant

Kf

3.6E-5 [s-1]

reverse rate constant

Kr

0.0 [molecules.um-2.s-1.uM-1]

Expressions for 034

reaction rate

J

((Vmax * MEK) / (Km + MEK)) [uM.s-1]

Km (1/2 max)

Km

0.15909 [uM]

max reaction rate

Vmax

(Kcat * BRaf_Pi) [uM.s-1]

local

Kcat

0.18 [s-1]

Expressions for 063

reaction rate

J

((Vmax * BRaf_Pi) / (Km + BRaf_Pi)) [uM.s-1]

Km (1/2 max)

Km

15.657 [uM]

max reaction rate

Vmax

(Kcat * PP2A) [uM.s-1]

local

Kcat

6.0 [s-1]

Expressions for r47

reaction rate

J

((Kf * DARPP32_Pi_PP1) - ((Kr * PP1) * DARPP32)) [uM.s-1]

forward rate constant

Kf

10.0 [s-1]

reverse rate constant

Kr

0.0 [s-1.uM-1]

Expressions for 095

reaction rate

J

((Vmax * CaMKII_CaM) / (Km + CaMKII_CaM)) [uM.s-1]

Km (1/2 max)

Km

113.6 [uM]

max reaction rate

Vmax

(Kcat * CaMKII) [uM.s-1]

local

Kcat

0.5 [s-1]

Expressions for 065

reaction rate

J

(((Kf * Gaby) * D1R) - (Kr * D1R_Gaby)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

forward rate constant

Kf

0.06 [um2.s-1.molecules-1]

reverse rate constant

Kr

3.0E-4 [s-1]

Expressions for r51

reaction rate

J

(((Kf * PDE2) * IBMX) - (Kr * PDE2_IBMX)) [uM.s-1]

forward rate constant

Kf

8.0 [s-1.uM-1]

reverse rate constant

Kr

0.8 [s-1]

Expressions for 029

reaction rate

J

((Vmax * MEK_Ser) / (Km + MEK_Ser)) [uM.s-1]

Km (1/2 max)

Km

0.15909 [uM]

max reaction rate

Vmax

(0.3 * Ras_Raf_active) [uM.s-1]

Expressions for 089

reaction rate

J

(((Kf * CaM) * pow(Calcium,2.0)) - (Kr * CaM_Ca2)) [uM.s-1]

forward rate constant

Kf

72.0 [s-1.uM-2]

reverse rate constant

Kr

72.0 [s-1]

Expressions for r43

reaction rate

J

((Kf * Calcium_ER) - (Kr * Calcium)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

forward rate constant

Kf

5.34E-4 [molecules.um-2.s-1.uM-1]

reverse rate constant

Kr

5.34E-4 [molecules.um-2.s-1.uM-1]

Expressions for r53

reaction rate

J

(((Kf * I1_Pi) * PP1) - (Kr * I1_Pi_PP1)) [uM.s-1]

forward rate constant

Kf

150.0 [s-1.uM-1]

reverse rate constant

Kr

0.1 [s-1]

Expressions for r33

reaction rate

J

((Vmax * PIP2) / (Km + PIP2)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

Km (1/2 max)

Km

19.8413 [molecules.um-2]

max reaction rate

Vmax

(Kcat * PLC_Ca) [molecules.um-2.s-1]

local

Kcat

10.0 [s-1]

Expressions for 082

reaction rate

J

(((Kf * R2C2) * cAMP) - (Kr * R2C2_cAMP)) [uM.s-1]

forward rate constant

Kf

54.0 [s-1.uM-1]

reverse rate constant

Kr

33.0 [s-1]

Expressions for 040

reaction rate

J

((Vmax * STEP) / (Km + STEP)) [uM.s-1]

Km (1/2 max)

Km

25.641 [uM]

max reaction rate

Vmax

(Kcat * PKA_active) [uM.s-1]

local

Kcat

1.0 [s-1]

Expressions for r9

reaction rate

J

(((Kf * PDE4) * Rolipram) - (Kr * PDE4_Rolipram)) [uM.s-1]

forward rate constant

Kf

1.0 [s-1.uM-1]

reverse rate constant

Kr

0.019 [s-1]

Expressions for 052

reaction rate

J

((Vmax * PDE4_ERK) / (Km + PDE4_ERK)) [uM.s-1]

Km (1/2 max)

Km

7.5 [uM]

max reaction rate

Vmax

(Kcat * PKA_active) [uM.s-1]

local

Kcat

0.1 [s-1]

Expressions for 070

reaction rate

J

(((Kf * Da) * D5R_Gaby) - (Kr * Da_D5R_Gaby)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

forward rate constant

Kf

3.33 [s-1.uM-1]

reverse rate constant

Kr

1.0 [s-1]

Expressions for r30

reaction rate

J

((Kf * Gq_GTP) - (Kr * Gq_GDP)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

forward rate constant

Kf

10.0 [s-1]

reverse rate constant

Kr

0.0 [s-1]

Expressions for 069

reaction rate

J

(((Kf * Gaby) * D5R) - (Kr * D5R_Gaby)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

forward rate constant

Kf

0.06 [um2.s-1.molecules-1]

reverse rate constant

Kr

3.0E-4 [s-1]

Expressions for 079

reaction rate

J

((Vmax * cAMP) / (Km + cAMP)) [uM.s-1]

Km (1/2 max)

Km

1.8 [uM]

max reaction rate

Vmax

(Kcat * PDE4_PKA) [uM.s-1]

local

Kcat

27.0 [s-1]

Expressions for r4

reaction rate

J

((Vmax * ATP) / (Km + ATP)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

Km (1/2 max)

Km

1030.0 [uM]

max reaction rate

Vmax

(Kcat * AC5) [molecules.um-2.s-1]

local

Kcat

0.2 [s-1]

Expressions for 037

reaction rate

J

((Vmax * ERK_Tyr) / (Km + ERK_Tyr)) [uM.s-1]

Km (1/2 max)

Km

0.046296 [uM]

max reaction rate

Vmax

(Kcat * MEK_active) [uM.s-1]

local

Kcat

0.15 [s-1]

Expressions for 016

reaction rate

J

(((Kf * Ras_GTP) * Raf) - (Kr * Ras_Raf_active)) [uM.s-1]

forward rate constant

Kf

6.0 [s-1.uM-1]

reverse rate constant

Kr

1.0 [s-1]

Expressions for 074

reaction rate

J

((Kf * Ga_GTP) - (Kr * Ga_GDP)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

forward rate constant

Kf

10.0 [s-1]

reverse rate constant

Kr

0.0 [s-1]

Expressions for 093

reaction rate

J

(((Kf * CaMKII_286) * CaM_Ca4) - (Kr * CaMKII_286_CaM)) [uM.s-1]

forward rate constant

Kf

1000.0 [s-1.uM-1]

reverse rate constant

Kr

0.1 [s-1]

Expressions for r54

reaction rate

J

((Kf * I1_Pi_PP1) - ((Kr * PP1) * I1)) [uM.s-1]

forward rate constant

Kf

1.0 [s-1]

reverse rate constant

Kr

0.0 [s-1.uM-1]

Expressions for 080

reaction rate

J

((Vmax * cAMP) / (Km + cAMP)) [uM.s-1]

Km (1/2 max)

Km

39.7 [uM]

max reaction rate

Vmax

(Kcat * PDE1) [uM.s-1]

local

Kcat

1.667 [s-1]

Expressions for 072

reaction rate

J

((Kf * Da_D1R_Gaby) - (((Kr * Gby) * Ga_GTP) * Da_D1R)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

forward rate constant

Kf

20.0 [s-1]

reverse rate constant

Kr

0.0 [um4.s-1.molecules-2]

Expressions for 049

reaction rate

J

((Vmax * PDE4_PKA) / (Km + PDE4_PKA)) [uM.s-1]

Km (1/2 max)

Km

25.641 [uM]

max reaction rate

Vmax

(Kcat * ERK_active) [uM.s-1]

local

Kcat

0.1 [s-1]

Expressions for r16

reaction rate

J

(((Kf * MEK) * U0126) - (Kr * MEK_inhibited)) [uM.s-1]

forward rate constant

Kf

1.0 [s-1.uM-1]

reverse rate constant

Kr

0.03 [s-1]

Expressions for r39

reaction rate

J

((Vmax * IP3_145) / (Km + IP3_145)) [uM.s-1]

Km (1/2 max)

Km

3.0 [uM]

max reaction rate

Vmax

(Kcat * IP3_5pase1) [uM.s-1]

local

Kcat

1.1 [s-1]

Expressions for 068

reaction rate

J

(((Kf * D5R) * Da) - (Kr * Da_D5R)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

forward rate constant

Kf

1.11 [s-1.uM-1]

reverse rate constant

Kr

1.0 [s-1]

Expressions for 047

reaction rate

J

((Vmax * PDE4) / (Km + PDE4)) [uM.s-1]

Km (1/2 max)

Km

0.47 [uM]

max reaction rate

Vmax

(Kcat * ERK_active) [uM.s-1]

local

Kcat

10.0 [s-1]

Expressions for r5

reaction rate

J

(((Kf * PDE1_CaM_Ca4) * IBMX) - (Kr * PDE1_IBMX)) [uM.s-1]

forward rate constant

Kf

8.0 [s-1.uM-1]

reverse rate constant

Kr

0.8 [s-1]

Expressions for 044

reaction rate

J

((Vmax * ERK_Tyr) / (Km + ERK_Tyr)) [uM.s-1]

Km (1/2 max)

Km

9.0 [uM]

max reaction rate

Vmax

(Kcat * STEP_PKA) [uM.s-1]

local

Kcat

0.1 [s-1]

Expressions for 083

reaction rate

J

(((Kf * cAMP) * R2C2_cAMP) - (Kr * R2C2_cAMP2)) [uM.s-1]

forward rate constant

Kf

54.0 [s-1.uM-1]

reverse rate constant

Kr

33.0 [s-1]

Expressions for 090

reaction rate

J

(((Kf * CaM_Ca2) * Calcium) - (Kr * CaM_Ca3)) [uM.s-1]

forward rate constant

Kf

3.6 [s-1.uM-1]

reverse rate constant

Kr

10.0 [s-1]

Expressions for r45

reaction rate

J

(J0 * Kc * (Calcium_ER - Calcium) * IP3R_open / (Kc + Calcium)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

local

J0

0.8 [uM-1.s-1]

local

Kc

4.69 [uM]

Expressions for 028

reaction rate

J

((Vmax * MEK) / (Km + MEK)) [uM.s-1]

Km (1/2 max)

Km

0.15909 [uM]

max reaction rate

Vmax

(0.3 * Ras_Raf_active) [uM.s-1]

Expressions for 094

reaction rate

J

((Kf * CaMKII) - (Kr * CaMKII_286)) [uM.s-1]

forward rate constant

Kf

0.003 [s-1]

reverse rate constant

Kr

0.0 [s-1]

Expressions for 003

reaction rate

J

((Kf * BDNF_TrkB2) - (Kr * BDNF_TrkB2_Pi)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

forward rate constant

Kf

0.02 [s-1]

reverse rate constant

Kr

0.0 [molecules.um-2.s-1.uM-1]

Expressions for 035

reaction rate

J

((Vmax * MEK_Ser) / (Km + MEK_Ser)) [uM.s-1]

Km (1/2 max)

Km

0.15909 [uM]

max reaction rate

Vmax

(Kcat * BRaf_Pi) [uM.s-1]

local

Kcat

0.18 [s-1]

Expressions for 033

reaction rate

J

((Vmax * MEK_active) / (Km + MEK_active)) [uM.s-1]

Km (1/2 max)

Km

15.657 [uM]

max reaction rate

Vmax

(Kcat * PP2A) [uM.s-1]

local

Kcat

6.0 [s-1]

Expressions for r14

reaction rate

J

(((Kf * MEK_Ser) * U0126) - (Kr * MEK_inhibited)) [uM.s-1]

forward rate constant

Kf

1.0 [s-1.uM-1]

reverse rate constant

Kr

0.03 [s-1]

Expressions for r15

reaction rate

J

(((Kf * MEK_active) * U0126) - (Kr * MEK_inhibited)) [uM.s-1]

forward rate constant

Kf

1.0 [s-1.uM-1]

reverse rate constant

Kr

0.03 [s-1]

Expressions for 108

reaction rate

J

((Vmax * GluR1_845) / (Km + GluR1_845)) [uM.s-1]

Km (1/2 max)

Km

0.97145 [uM]

max reaction rate

Vmax

(Kcat * PP1) [uM.s-1]

local

Kcat

0.17 [s-1]

Expressions for r57

reaction rate

J

((Vmax * GluR1_845) / (Km + GluR1_845)) [uM.s-1]

Km (1/2 max)

Km

33.0 [uM]

max reaction rate

Vmax

(Kcat * PKC_active) [uM.s-1]

local

Kcat

4.0 [s-1]

Expressions for r8

reaction rate

J

(((Kf * Rolipram) * PDE4_ERK) - (Kr * PDE4_Rolipram)) [uM.s-1]

forward rate constant

Kf

1.0 [s-1.uM-1]

reverse rate constant

Kr

0.019 [s-1]

Expressions for r23

reaction rate

J

(((Kf * PDE4_ERK_PKA) * IBMX) - (Kr * PDE4_IBMX)) [uM.s-1]

forward rate constant

Kf

8.0 [s-1.uM-1]

reverse rate constant

Kr

0.8 [s-1]

Expressions for r13

reaction rate

J

(((Kf * Gqby) * D1LR) - (Kr * D1LR_Gqby)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

forward rate constant

Kf

0.06 [um2.s-1.molecules-1]

reverse rate constant

Kr

3.0E-4 [s-1]

Expressions for 061

reaction rate

J

((Vmax * I1_Pi) / (Km + I1_Pi)) [uM.s-1]

Km (1/2 max)

Km

16.0 [uM]

max reaction rate

Vmax

(Kcat * PP2A_DI) [uM.s-1]

local

Kcat

2.0 [s-1]

Expressions for 066

reaction rate

J

(((Kf * Gaby) * Da_D1R) - (Kr * Da_D1R_Gaby)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

forward rate constant

Kf

0.6 [um2.s-1.molecules-1]

reverse rate constant

Kr

0.001 [s-1]

Expressions for 014

reaction rate

J

((Kf * Ras_GTP) - (Kr * Ras_GDP)) [uM.s-1]

forward rate constant

Kf

1.0E-4 [s-1]

reverse rate constant

Kr

0.0 [s-1]

Expressions for r17

reaction rate

J

((Vmax * GluR1_Membrane) / (Km + GluR1_Membrane)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

Km (1/2 max)

Km

0.97145 [molecules.um-2]

max reaction rate

Vmax

(Kcat * PP1) [molecules.um-2.s-1]

local

Kcat

0.17 [molecules.um-2.uM-1.s-1]

Expressions for 062

reaction rate

J

((Vmax * BRaf) / (Km + BRaf)) [uM.s-1]

Km (1/2 max)

Km

7.5 [uM]

max reaction rate

Vmax

(Kcat * PKA_active) [uM.s-1]

local

Kcat

3.0 [s-1]

Expressions for r42

reaction rate

J

(SERCA / (1.0 + (2.5 / (Calcium * Calcium)) + (0.25 / Calcium))) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

Expressions for 099

reaction rate

J

((Kf * PDE1_CaM_Ca4) - (Kr * PDE1)) [uM.s-1]

forward rate constant

Kf

0.1 [s-1]

reverse rate constant

Kr

0.0 [s-1]

Expressions for r25

reaction rate

J

((Vmax * ATP) / (Km + ATP)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

Km (1/2 max)

Km

315.0 [uM]

max reaction rate

Vmax

(Kcat * AC5_Fsk) [molecules.um-2.s-1]

local

Kcat

8.5 [s-1]

Expressions for 086

reaction rate

J

((Kf * R2C2_cAMP4) - ((Kr * PKA_active) * R2C_cAMP4)) [uM.s-1]

forward rate constant

Kf

60.0 [s-1]

reverse rate constant

Kr

18.0 [s-1.uM-1]

Expressions for r41

reaction rate

J

(((Kf * IP3R) * pow(IP3_145,3.0)) - (Kr * IP3R_open)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

forward rate constant

Kf

1.0 [s-1.uM-3]

reverse rate constant

Kr

2.7 [s-1]

Expressions for 048

reaction rate

J

((Vmax * PDE4_ERK) / (Km + PDE4_ERK)) [uM.s-1]

Km (1/2 max)

Km

8.0 [uM]

max reaction rate

Vmax

(Kcat * PP1_PDE) [uM.s-1]

local

Kcat

5.0 [s-1]

Expressions for 043

reaction rate

J

((Vmax * ERK_Tyr) / (Km + ERK_Tyr)) [uM.s-1]

Km (1/2 max)

Km

0.46 [uM]

max reaction rate

Vmax

(Kcat * STEP) [uM.s-1]

local

Kcat

1.06 [s-1]

Expressions for 085

reaction rate

J

(((Kf * R2C2_cAMP3) * cAMP) - (Kr * R2C2_cAMP4)) [uM.s-1]

forward rate constant

Kf

75.0 [s-1.uM-1]

reverse rate constant

Kr

32.5 [s-1]

Expressions for 092

reaction rate

J

(((Kf * CaM_Ca4) * CaMKII) - (Kr * CaMKII_CaM)) [uM.s-1]

forward rate constant

Kf

50.0 [s-1.uM-1]

reverse rate constant

Kr

5.0 [s-1]

Expressions for 041

reaction rate

J

((Vmax * STEP_PKA) / (Km + STEP_PKA)) [uM.s-1]

Km (1/2 max)

Km

6.0 [uM]

max reaction rate

Vmax

(Kcat * PP1) [uM.s-1]

local

Kcat

5.0 [s-1]

Structures

Name
Type
Electrical
PM Membrane IC(+)   EC(-)
ER_Membrane Membrane ER(+)   IC(-)
IC Compartment (+)   (-)
EC Compartment (+)   (-)
ER Compartment (+)   (-)

PM Universal ID's

PM Text Annotations

ER_Membrane Universal ID's

ER_Membrane Text Annotations

IC Universal ID's

IC Text Annotations

EC Universal ID's

EC Text Annotations

ER Universal ID's

ER Text Annotations

Species

Name
Structure
BioNetGen Definition
Depiction
BDNF EC EC
CaM_Ca4 IC IC
PDE2_IBMX IC IC
Gap IC IC
R2C2_cAMP3 IC IC
SoS_Pi_Grb2 IC IC
PDE4_ERK_PKA IC IC
Gby PM PM
R2C2_cAMP IC IC
AC5_Ga PM PM
D1LR_Gqby PM PM
PP1 IC IC
DARPP32_Pi_PP1 IC IC
I1_Pi_PP1 IC IC
PDE4_ERK IC IC
AMPAR_Bulk IC IC
GluR1_Membrane PM PM
Gqby PM PM
PLC PM PM
PLC_Ca PM PM
PLC_Ca_Gq PM PM
IP3_degraded IC IC
IP3_14 IC IC
IP3R ER_Membrane ER_Membrane
AC_basal PM PM
G_by PM PM
Gq_GDP PM PM
PKC_active IC IC
PP2A IC IC
Da_D5R PM PM
PP1_PDE IC IC
cAMP IC IC
Gaby PM PM
U0126 IC IC
DARPP32 IC IC
Rolipram IC IC
Da_D5R_Gaby PM PM
AC5 PM PM
R2C_cAMP4 IC IC
PDE3_IBMX IC IC
R2_cAMP4 IC IC
BDNF_TrkB PM PM
AC5_Fsk PM PM
STEP_PKA IC IC
BRaf_Pi IC IC
D1R_Gaby PM PM
Gq_GTP PM PM
PDE1_CaM_Ca4 IC IC
GluR1_845_818 IC IC
Raf IC IC
IBMX IC IC
PDEbg IC IC
PKA_active IC IC
PDE1_IBMX IC IC
TrkB PM PM
GluR1_degraded IC IC
GluR1 IC IC
MEK_Ser IC IC
IP3R_open ER_Membrane ER_Membrane
ERK_Tyr IC IC
D1LR PM PM
Da EC EC
SERCA ER_Membrane ER_Membrane
SERCA_active ER_Membrane ER_Membrane
IP3_5pase1 IC IC
PLC_Gq PM PM
PDE4_PKA IC IC
MEK IC IC
Ga_GDP PM PM
CaM IC IC
Fsk EC EC
Four1N IC IC
PDE4_IBMX IC IC
D5R_Gaby PM PM
BDNF_TrkB2 PM PM
I1_Pi IC IC
ERK IC IC
Ga_GTP PM PM
PDE4_Rolipram IC IC
PKA_Inhibitor IC IC
CaMKII_286_CaM IC IC
Ras_GDP IC IC
MEK_inhibited IC IC
R2C2_cAMP4 IC IC
Ras_Raf_active IC IC
Da_D1R_Gaby PM PM
SoS_Grb2 IC IC
ATP IC IC
GluR1_845 IC IC
IP3_5Pase2 IC IC
Shc IC IC
Ras_GTP IC IC
R2C2 IC IC
D1R PM PM
PIP2 PM PM
Da_D1LR_Gqby PM PM
Int_TrkB2 PM PM
CaMKII IC IC
BRaf IC IC
R2C2_cAMP2 IC IC
PDE1 IC IC
CaM_Ca2 IC IC
PDE2 IC IC
BDNF_TrkB2_Pi IC IC
ERK_active IC IC
Shc_Pi IC IC
DAG PM PM
IP3_145 IC IC
MEK_active IC IC
AMP IC IC
Grb2 IC IC
STEP IC IC
PDE3 IC IC
Calcium IC IC
CaMKII_CaM IC IC
SoS IC IC
PDE4 IC IC
CaMKII_286 IC IC
Da_D1R PM PM
SoS_Pi IC IC
D5R PM PM
PKA_inhibited IC IC
CaM_Ca3 IC IC
Calcium_ER ER ER
GluR1_Membrane_dephosphorylated1 PM PM
I1 IC IC
Da_D1LR PM PM
DARPP32_Pi IC IC
Shc_Pi_SoS_Grb2 IC IC
PP2A_DI IC IC

BDNF Universal ID's

BDNF Text Annotations

CaM_Ca4 Universal ID's

CaM_Ca4 Text Annotations

PDE2_IBMX Universal ID's

PDE2_IBMX Text Annotations

Gap Universal ID's

Gap Text Annotations

R2C2_cAMP3 Universal ID's

R2C2_cAMP3 Text Annotations

SoS_Pi_Grb2 Universal ID's

SoS_Pi_Grb2 Text Annotations

PDE4_ERK_PKA Universal ID's

PDE4_ERK_PKA Text Annotations

Gby Universal ID's

Gby Text Annotations

R2C2_cAMP Universal ID's

R2C2_cAMP Text Annotations

AC5_Ga Universal ID's

AC5_Ga Text Annotations

D1LR_Gqby Universal ID's

D1LR_Gqby Text Annotations

PP1 Universal ID's

PP1 Text Annotations

DARPP32_Pi_PP1 Universal ID's

DARPP32_Pi_PP1 Text Annotations

I1_Pi_PP1 Universal ID's

I1_Pi_PP1 Text Annotations

PDE4_ERK Universal ID's

PDE4_ERK Text Annotations

AMPAR_Bulk Universal ID's

AMPAR_Bulk Text Annotations

GluR1_Membrane Universal ID's

GluR1_Membrane Text Annotations

Gqby Universal ID's

Gqby Text Annotations

PLC Universal ID's

PLC Text Annotations

PLC_Ca Universal ID's

PLC_Ca Text Annotations

PLC_Ca_Gq Universal ID's

PLC_Ca_Gq Text Annotations

IP3_degraded Universal ID's

IP3_degraded Text Annotations

IP3_14 Universal ID's

IP3_14 Text Annotations

IP3R Universal ID's

IP3R Text Annotations

AC_basal Universal ID's

AC_basal Text Annotations

G_by Universal ID's

G_by Text Annotations

Gq_GDP Universal ID's

Gq_GDP Text Annotations

PKC_active Universal ID's

PKC_active Text Annotations

PP2A Universal ID's

PP2A Text Annotations

Da_D5R Universal ID's

Da_D5R Text Annotations

PP1_PDE Universal ID's

PP1_PDE Text Annotations

cAMP Universal ID's

cAMP Text Annotations

Gaby Universal ID's

Gaby Text Annotations

U0126 Universal ID's

U0126 Text Annotations

DARPP32 Universal ID's

DARPP32 Text Annotations

Rolipram Universal ID's

Rolipram Text Annotations

Da_D5R_Gaby Universal ID's

Da_D5R_Gaby Text Annotations

AC5 Universal ID's

AC5 Text Annotations

R2C_cAMP4 Universal ID's

R2C_cAMP4 Text Annotations

PDE3_IBMX Universal ID's

PDE3_IBMX Text Annotations

R2_cAMP4 Universal ID's

R2_cAMP4 Text Annotations

BDNF_TrkB Universal ID's

BDNF_TrkB Text Annotations

AC5_Fsk Universal ID's

AC5_Fsk Text Annotations

STEP_PKA Universal ID's

STEP_PKA Text Annotations

BRaf_Pi Universal ID's

BRaf_Pi Text Annotations

D1R_Gaby Universal ID's

D1R_Gaby Text Annotations

Gq_GTP Universal ID's

Gq_GTP Text Annotations

PDE1_CaM_Ca4 Universal ID's

PDE1_CaM_Ca4 Text Annotations

GluR1_845_818 Universal ID's

GluR1_845_818 Text Annotations

Raf Universal ID's

Raf Text Annotations

IBMX Universal ID's

IBMX Text Annotations

PDEbg Universal ID's

PDEbg Text Annotations

PKA_active Universal ID's

PKA_active Text Annotations

PDE1_IBMX Universal ID's

PDE1_IBMX Text Annotations

TrkB Universal ID's

TrkB Text Annotations

GluR1_degraded Universal ID's

GluR1_degraded Text Annotations

GluR1 Universal ID's

GluR1 Text Annotations

MEK_Ser Universal ID's

MEK_Ser Text Annotations

IP3R_open Universal ID's

IP3R_open Text Annotations

ERK_Tyr Universal ID's

ERK_Tyr Text Annotations

D1LR Universal ID's

D1LR Text Annotations

Da Universal ID's

Da Text Annotations

SERCA Universal ID's

SERCA Text Annotations

SERCA_active Universal ID's

SERCA_active Text Annotations

IP3_5pase1 Universal ID's

IP3_5pase1 Text Annotations

PLC_Gq Universal ID's

PLC_Gq Text Annotations

PDE4_PKA Universal ID's

PDE4_PKA Text Annotations

MEK Universal ID's

MEK Text Annotations

Ga_GDP Universal ID's

Ga_GDP Text Annotations

CaM Universal ID's

CaM Text Annotations

Fsk Universal ID's

Fsk Text Annotations

Four1N Universal ID's

Four1N Text Annotations

PDE4_IBMX Universal ID's

PDE4_IBMX Text Annotations

D5R_Gaby Universal ID's

D5R_Gaby Text Annotations

BDNF_TrkB2 Universal ID's

BDNF_TrkB2 Text Annotations

I1_Pi Universal ID's

I1_Pi Text Annotations

ERK Universal ID's

ERK Text Annotations

Ga_GTP Universal ID's

Ga_GTP Text Annotations

PDE4_Rolipram Universal ID's

PDE4_Rolipram Text Annotations

PKA_Inhibitor Universal ID's

PKA_Inhibitor Text Annotations

CaMKII_286_CaM Universal ID's

CaMKII_286_CaM Text Annotations

Ras_GDP Universal ID's

Ras_GDP Text Annotations

MEK_inhibited Universal ID's

MEK_inhibited Text Annotations

R2C2_cAMP4 Universal ID's

R2C2_cAMP4 Text Annotations

Ras_Raf_active Universal ID's

Ras_Raf_active Text Annotations

Da_D1R_Gaby Universal ID's

Da_D1R_Gaby Text Annotations

SoS_Grb2 Universal ID's

SoS_Grb2 Text Annotations

ATP Universal ID's

ATP Text Annotations

GluR1_845 Universal ID's

GluR1_845 Text Annotations

IP3_5Pase2 Universal ID's

IP3_5Pase2 Text Annotations

Shc Universal ID's

Shc Text Annotations

Ras_GTP Universal ID's

Ras_GTP Text Annotations

R2C2 Universal ID's

R2C2 Text Annotations

D1R Universal ID's

D1R Text Annotations

PIP2 Universal ID's

PIP2 Text Annotations

Da_D1LR_Gqby Universal ID's

Da_D1LR_Gqby Text Annotations

Int_TrkB2 Universal ID's

Int_TrkB2 Text Annotations

CaMKII Universal ID's

CaMKII Text Annotations

BRaf Universal ID's

BRaf Text Annotations

R2C2_cAMP2 Universal ID's

R2C2_cAMP2 Text Annotations

PDE1 Universal ID's

PDE1 Text Annotations

CaM_Ca2 Universal ID's

CaM_Ca2 Text Annotations

PDE2 Universal ID's

PDE2 Text Annotations

BDNF_TrkB2_Pi Universal ID's

BDNF_TrkB2_Pi Text Annotations

ERK_active Universal ID's

ERK_active Text Annotations

Shc_Pi Universal ID's

Shc_Pi Text Annotations

DAG Universal ID's

DAG Text Annotations

IP3_145 Universal ID's

IP3_145 Text Annotations

MEK_active Universal ID's

MEK_active Text Annotations

AMP Universal ID's

AMP Text Annotations

Grb2 Universal ID's

Grb2 Text Annotations

STEP Universal ID's

STEP Text Annotations

PDE3 Universal ID's

PDE3 Text Annotations

Calcium Universal ID's

Calcium Text Annotations

CaMKII_CaM Universal ID's

CaMKII_CaM Text Annotations

SoS Universal ID's

SoS Text Annotations

PDE4 Universal ID's

PDE4 Text Annotations

CaMKII_286 Universal ID's

CaMKII_286 Text Annotations

Da_D1R Universal ID's

Da_D1R Text Annotations

SoS_Pi Universal ID's

SoS_Pi Text Annotations

D5R Universal ID's

D5R Text Annotations

PKA_inhibited Universal ID's

PKA_inhibited Text Annotations

CaM_Ca3 Universal ID's

CaM_Ca3 Text Annotations

Calcium_ER Universal ID's

Calcium_ER Text Annotations

GluR1_Membrane_dephosphorylated1 Universal ID's

GluR1_Membrane_dephosphorylated1 Text Annotations

I1 Universal ID's

I1 Text Annotations

Da_D1LR Universal ID's

Da_D1LR Text Annotations

DARPP32_Pi Universal ID's

DARPP32_Pi Text Annotations

Shc_Pi_SoS_Grb2 Universal ID's

Shc_Pi_SoS_Grb2 Text Annotations

PP2A_DI Universal ID's

PP2A_DI Text Annotations

Molecules

Name
BioNetGen Definition
DEPICTION

Observables

Name
Structure
Count
BNGL Definition
Sequence Type
DEPICTION

Applications

Name
Properties Math Type
Annotation
Application0 Specs - Species
Specs - Reaction
Simulations 		Deterministic (ODE) Compartmental

Application0 Universal ID's

Application0 Text Annotations

Specifications (Species) - Application0 go to Simulations

Species
Initial Condition
Diffusion Constant
Structure
CaM_Ca4 0.0 [uM] 0.0 [um2/s] IC
PDE2_IBMX 0.0 [uM] 0.0 [um2/s] IC
Gap 0.01 [uM] 1.0 [um2/s] IC
R2C2_cAMP3 0.0 [uM] 0.0 [um2/s] IC
SoS_Pi_Grb2 0.0 [uM] 1.0 [um2/s] IC
PDE4_ERK_PKA 0.0 [uM] 0.0 [um2/s] IC
R2C2_cAMP 0.0 [uM] 0.0 [um2/s] IC
PP1 0.25 [uM] 0.0 [um2/s] IC
DARPP32_Pi_PP1 0.0 [uM] 0.0 [um2/s] IC
I1_Pi_PP1 0.0 [uM] 0.0 [um2/s] IC
PDE4_ERK 0.0 [uM] 0.0 [um2/s] IC
AMPAR_Bulk 0.011111 [uM] 0.0 [um2/s] IC
IP3_degraded 0.0 [uM] 0.0 [um2/s] IC
IP3_14 0.0 [uM] 0.0 [um2/s] IC
PKC_active 0.05 [uM] 0.0 [um2/s] IC
PP2A 0.2 [uM] 0.0 [um2/s] IC
PP1_PDE 0.1 [uM] 0.0 [um2/s] IC
cAMP 0.0 [uM] 0.0 [um2/s] IC
U0126 0.0 [uM] 0.0 [um2/s] IC
DARPP32 0.5 [uM] 0.0 [um2/s] IC
Rolipram 0.0 [uM] 0.0 [um2/s] IC
R2C_cAMP4 0.0 [uM] 0.0 [um2/s] IC
PDE3_IBMX 0.0 [uM] 0.0 [um2/s] IC
R2_cAMP4 0.0 [uM] 0.0 [um2/s] IC
STEP_PKA 0.0 [uM] 0.0 [um2/s] IC
BRaf_Pi 0.0 [uM] 0.0 [um2/s] IC
PDE1_CaM_Ca4 0.0 [uM] 0.0 [um2/s] IC
GluR1_845_818 0.0 [uM] 0.0 [um2/s] IC
Raf 3.0 [uM] 1.0 [um2/s] IC
IBMX 0.0 [uM] 0.0 [um2/s] IC
PDEbg 3.0 [uM] 0.0 [um2/s] IC
PKA_active 0.0 [uM] 0.0 [um2/s] IC
PDE1_IBMX 0.0 [uM] 0.0 [um2/s] IC
GluR1_degraded 0.0 [uM] 0.0 [um2/s] IC
GluR1 0.0 [uM] 0.0 [um2/s] IC
MEK_Ser 0.0 [uM] 1.0 [um2/s] IC
ERK_Tyr 0.0 [uM] 1.0 [um2/s] IC
IP3_5pase1 12.0 [uM] 0.0 [um2/s] IC
PDE4_PKA 0.0 [uM] 0.0 [um2/s] IC
MEK 0.18 [uM] 1.0 [um2/s] IC
CaM 2.0 [uM] 0.0 [um2/s] IC
Four1N 0.01 [uM] 0.0 [um2/s] IC
PDE4_IBMX 0.0 [uM] 0.0 [um2/s] IC
I1_Pi 0.0 [uM] 0.0 [um2/s] IC
ERK 0.36 [uM] 1.0 [um2/s] IC
PDE4_Rolipram 0.0 [uM] 0.0 [um2/s] IC
PKA_Inhibitor 0.25 [uM] 0.0 [um2/s] IC
CaMKII_286_CaM 0.0 [uM] 0.0 [um2/s] IC
Ras_GDP 3.0 [uM] 1.0 [um2/s] IC
MEK_inhibited 0.0 [uM] 0.0 [um2/s] IC
R2C2_cAMP4 0.0 [uM] 0.0 [um2/s] IC
Ras_Raf_active 0.0 [uM] 1.0 [um2/s] IC
SoS_Grb2 0.0 [uM] 1.0 [um2/s] IC
ATP 2000.0 [uM] 0.0 [um2/s] IC
GluR1_845 0.0 [uM] 0.0 [um2/s] IC
IP3_5Pase2 0.463 [uM] 0.0 [um2/s] IC
Shc 1.0 [uM] 1.0 [um2/s] IC
Ras_GTP 0.0 [uM] 1.0 [um2/s] IC
R2C2 0.5 [uM] 0.0 [um2/s] IC
CaMKII 2.0 [uM] 0.0 [um2/s] IC
BRaf 0.18 [uM] 0.0 [um2/s] IC
R2C2_cAMP2 0.0 [uM] 0.0 [um2/s] IC
PDE1 1.0 [uM] 0.0 [um2/s] IC
CaM_Ca2 0.0 [uM] 0.0 [um2/s] IC
PDE2 1.0 [uM] 0.0 [um2/s] IC
BDNF_TrkB2_Pi 0.0 [uM] 0.0 [um2/s] IC
ERK_active 0.0 [uM] 1.0 [um2/s] IC
Shc_Pi 0.0 [uM] 1.0 [um2/s] IC
IP3_145 0.0 [uM] 0.0 [um2/s] IC
MEK_active 0.0 [uM] 1.0 [um2/s] IC
AMP 0.0 [uM] 0.0 [um2/s] IC
Grb2 1.0 [uM] 1.0 [um2/s] IC
STEP 0.2 [uM] 0.0 [um2/s] IC
PDE3 0.005 [uM] 0.0 [um2/s] IC
Calcium 0.08 [uM] 0.0 [um2/s] IC
CaMKII_CaM 0.0 [uM] 0.0 [um2/s] IC
SoS 1.0 [uM] 1.0 [um2/s] IC
PDE4 0.4 [uM] 0.0 [um2/s] IC
CaMKII_286 0.0 [uM] 0.0 [um2/s] IC
SoS_Pi 0.0 [uM] 1.0 [um2/s] IC
PKA_inhibited 0.0 [uM] 0.0 [um2/s] IC
CaM_Ca3 0.0 [uM] 0.0 [um2/s] IC
I1 0.68 [uM] 0.0 [um2/s] IC
DARPP32_Pi 0.0 [uM] 0.0 [um2/s] IC
Shc_Pi_SoS_Grb2 0.0 [uM] 1.0 [um2/s] IC
PP2A_DI 0.11111 [uM] 0.0 [um2/s] IC
BDNF 0.0 [uM] 1.0 [um2/s] EC
Da 0.0 [uM] 0.0 [um2/s] EC
Fsk 0.0 [uM] 0.0 [um2/s] EC
Calcium_ER 900.0 [uM] 0.0 [um2/s] ER
Gby 0.0 [uM] 0.0 [um2/s] PM
AC5_Ga 0.0 [uM] 0.0 [um2/s] PM
D1LR_Gqby 0.0 [uM] 0.0 [um2/s] PM
GluR1_Membrane 0.0 [uM] 0.0 [um2/s] PM
Gqby 20.0 [uM] 0.0 [um2/s] PM
PLC 20.0 [uM] 0.0 [um2/s] PM
PLC_Ca 0.0 [uM] 0.0 [um2/s] PM
PLC_Ca_Gq 0.0 [uM] 0.0 [um2/s] PM
AC_basal 11.8 [uM] 0.0 [um2/s] PM
G_by 0.0 [uM] 0.0 [um2/s] PM
Gq_GDP 0.0 [uM] 0.0 [um2/s] PM
Da_D5R 0.0 [uM] 0.0 [um2/s] PM
Gaby 100.0 [uM] 0.0 [um2/s] PM
Da_D5R_Gaby 0.0 [uM] 0.0 [um2/s] PM
AC5 45.0 [uM] 0.0 [um2/s] PM
BDNF_TrkB 0.0 [uM] 0.0 [um2/s] PM
AC5_Fsk 0.0 [uM] 0.0 [um2/s] PM
D1R_Gaby 0.0 [uM] 0.0 [um2/s] PM
Gq_GTP 0.0 [uM] 0.0 [um2/s] PM
TrkB 200.0 [uM] 0.0 [um2/s] PM
D1LR 20.0 [uM] 0.0 [um2/s] PM
PLC_Gq 0.0 [uM] 0.0 [um2/s] PM
Ga_GDP 0.0 [uM] 0.0 [um2/s] PM
D5R_Gaby 0.0 [uM] 0.0 [um2/s] PM
BDNF_TrkB2 0.0 [uM] 0.0 [um2/s] PM
Ga_GTP 0.0 [uM] 0.0 [um2/s] PM
Da_D1R_Gaby 0.0 [uM] 0.0 [um2/s] PM
D1R 100.0 [uM] 0.0 [um2/s] PM
PIP2 100.0 [uM] 0.0 [um2/s] PM
Da_D1LR_Gqby 0.0 [uM] 0.0 [um2/s] PM
Int_TrkB2 0.0 [uM] 0.0 [um2/s] PM
DAG 0.0 [uM] 0.0 [um2/s] PM
Da_D1R 0.0 [uM] 0.0 [um2/s] PM
D5R 10.0 [uM] 0.0 [um2/s] PM
GluR1_Membrane_dephosphorylated1 0.0 [uM] 0.0 [um2/s] PM
Da_D1LR 0.0 [uM] 0.0 [um2/s] PM
IP3R 100.0 [uM] 0.0 [um2/s] ER_Membrane
IP3R_open 0.0 [uM] 0.0 [um2/s] ER_Membrane
SERCA 250.0 [uM] 0.0 [um2/s] ER_Membrane
SERCA_active 0.0 [uM] 0.0 [um2/s] ER_Membrane

Specifications (Reaction) - Application0 go to Simulations

Name
Enabled?
091 included
005 included
r44 included
r19 included
r20 included
r40 included
057 included
r28 included
087 included
r10 included
r7 included
r21 included
096 included
056 included
036 included
064 included
r52 included
078 included
103 included
073 included
r38 included
r12 included
r6 included
100 included
r0 included
r11 included
r3 included
r55 included
011 included
012 included
097 included
071 included
002 included
r35 included
023 included
001 included
r36 included
084 included
098 included
r26 included
081 included
104 included
077 included
032 included
008 included
006 included
r27 included
046 included
060 included
018 included
r48 included
045 included
075 included
009 included
r50 included
004 included
r56 included
r37 included
r32 included
007 included
106 included
r29 included
067 included
088 included
r24 included
r31 included
r22 included
r34 included
010 included
r18 included
r1 included
r49 included
105 included
034 included
063 included
r47 included
095 included
065 included
r51 included
029 included
089 included
r43 included
r53 included
r33 included
082 included
040 included
r9 included
052 included
070 included
r30 included
069 included
079 included
r4 included
037 included
016 included
074 included
093 included
r54 included
080 included
072 included
049 included
r16 included
r39 included
068 included
047 included
r5 included
044 included
083 included
090 included
r45 included
028 included
094 included
003 included
035 included
033 included
r14 included
r15 included
108 included
r57 included
r8 included
r23 included
r13 included
061 included
066 included
014 included
r17 included
062 included
r42 included
099 included
r25 included
086 included
r41 included
048 included
043 included
085 included
092 included
041 included

Simulations - Application0 go to Specifications

Name
End Time
Output Options
DA0.1 6000.0

OutputTimeStep 60.0
DA0.1+U0126 5400.0

OutputTimeStep 60.0
DA0.1+Rolipram 5400.0

OutputTimeStep 60.0
DA0.1+BDNF 5400.0

OutputTimeStep 60.0
DA1.0 6000.0

OutputTimeStep 60.0
DA1.0+U0126 5400.0

OutputTimeStep 60.0
DA1.0+Rolipram 5400.0

OutputTimeStep 60.0
DA1.0+BDNF 5400.0

OutputTimeStep 60.0

Application0 Universal ID's

Application0 Text Annotations

Application0 Universal ID's

Application0 Text Annotations

Application0 Universal ID's

Application0 Text Annotations

Application0 Universal ID's

Application0 Text Annotations

Application0 Universal ID's

Application0 Text Annotations

Application0 Universal ID's

Application0 Text Annotations

Application0 Universal ID's

Application0 Text Annotations

Application0 Universal ID's

Application0 Text Annotations

Assignments

Name Variable Assignment Function Expression

Events

Name Trigger Type Variable Assignment
t3600 on condition: 3600.0 Da --> 0.1, U0126 --> 0.0, Rolipram --> 0.0, BDNF --> 0.0
t5400 on condition: 5400.0 IBMX --> 10.0, Fsk --> 10.0

Geometry non-spatial1634669173

(Origin: 0.0, 0.0, 0.0; Extent: 10.0, 10.0, 10.0 [um])

Dimension Type Subdomain Adjacent Subvolumes Size Mapped Compartment
Compartmental Compartment ER_Membrane

Events

Name Variable Rate Expression

Global Parameters

Name
Expression

Downloads

Model Format
Model Downloads
Virtual Cell Markup Language VCML File
PDF Report Report
COMBINE Archive OMEX File
SEDML SEDML File
File Format
Application Downloads
BNGL Application0.bngl
SBML Application0.sbml
Matlab Application0.m
NFSim XML Application0.xml