Physiology
Reaction Diagram
Cross-References
Annotations
Reactions
Reactions | Name | Structure | Kinetics | Depiction |
---|---|---|---|---|
CaM_Ca3+CalciumCaM_Ca4 | 091 | IC | MassAction | |
Int_TrkB2TrkB | 005 | PM | MassAction | |
CalciumCalcium_ER | r44 | ER_Membrane | GeneralKinetics | |
PDE1+IBMXPDE1_IBMX | r19 | IC | MassAction | |
Da+D1LR_GqbyDa_D1LR_Gqby | r20 | PM | MassAction | |
IP3_145IP3_14 | r40 | IC | HMMIrreversible | |
DARPP32_PiDARPP32 | 057 | IC | HMMIrreversible | |
Da_D1LR_GqbyG_by+Da_D1LR+Gq_GTP | r28 | PM | MassAction | |
R2C_cAMP4PKA_active+R2_cAMP4 | 087 | IC | MassAction | |
Rolipram+PDE4_ERK_PKAPDE4_Rolipram | r10 | IC | MassAction | |
AC5+FskAC5_Fsk | r7 | PM | MassAction | |
IBMX+PDE4PDE4_IBMX | r21 | IC | MassAction | |
CaMKII_286CaMKII | 096 | IC | HMMIrreversible | |
DARPP32DARPP32_Pi | 056 | IC | HMMIrreversible | |
ERKERK_Tyr | 036 | IC | HMMIrreversible | |
Da+D1RDa_D1R | 064 | PM | MassAction | |
cAMPAMP | r52 | IC | HMMIrreversible | |
cAMPAMP | 078 | IC | HMMIrreversible | |
Four1N+GluR1_845_818GluR1_Membrane | 103 | PM | MassAction | |
Ga_GDP+GbyGaby | 073 | PM | MassAction | |
IP3_145IP3_degraded | r38 | IC | MassAction | |
cAMPAMP | r12 | IC | HMMIrreversible | |
PDE3+IBMXPDE3_IBMX | r6 | IC | MassAction | |
AMPAR_BulkGluR1 | 100 | IC | MassAction | |
Da_D5R_GabyDa_D5R+Gby+Ga_GTP | r0 | PM | MassAction | |
Rolipram+PDE4_PKAPDE4_Rolipram | r11 | IC | MassAction | |
ATPcAMP | r3 | PM | HMMIrreversible | |
PDE4_ERK_PKAPDE4 | r55 | IC | HMMIrreversible | |
ShcShc_Pi | 011 | IC | HMMIrreversible | |
SoSSoS_Pi | 012 | IC | HMMIrreversible | |
CaMKII_286_CaMCaMKII_CaM | 097 | IC | HMMIrreversible | |
Da_D5R+GabyDa_D5R_Gaby | 071 | PM | MassAction | |
TrkB+BDNF_TrkBBDNF_TrkB2 | 002 | PM | MassAction | |
PLC+CalciumPLC_Ca | r35 | PM | MassAction | |
Ras_GTPRas_GDP | 023 | IC | HMMIrreversible | |
BDNF+TrkBBDNF_TrkB | 001 | PM | MassAction | |
PLC_GqGq_GDP+PLC | r36 | PM | MassAction | |
R2C2_cAMP2+cAMPR2C2_cAMP3 | 084 | IC | MassAction | |
PDE1+CaM_Ca4PDE1_CaM_Ca4 | 098 | IC | MassAction | |
Da+D1LRDa_D1LR | r26 | PM | MassAction | |
cAMPAMP | 081 | IC | HMMIrreversible | |
GluR1_Membrane_dephosphorylated1GluR1+Four1N | 104 | PM | MassAction | |
cAMPAMP | 077 | IC | HMMIrreversible | |
MEK_SerMEK | 032 | IC | HMMIrreversible | |
SoS_Pi+Grb2SoS_Pi_Grb2 | 008 | IC | MassAction | |
Shc_PiShc | 006 | IC | MassAction | |
Da_D1LR+GqbyDa_D1LR_Gqby | r27 | PM | MassAction | |
PDE4_PKAPDE4 | 046 | IC | HMMIrreversible | |
I1I1_Pi | 060 | IC | HMMIrreversible | |
Ras_GDPRas_GTP | 018 | IC | HMMIrreversible | |
cAMPAMP | r48 | IC | HMMIrreversible | |
PDE4PDE4_PKA | 045 | IC | HMMIrreversible | |
Ga_GTP+AC5AC5_Ga | 075 | PM | MassAction | |
SoS_PiSoS | 009 | IC | MassAction | |
cAMPAMP | r50 | IC | HMMIrreversible | |
BDNF_TrkB2_PiInt_TrkB2 | 004 | PM | MassAction | |
GluR1_845_818GluR1_845 | r56 | IC | HMMIrreversible | |
PLC_Gq+CalciumPLC_Ca_Gq | r37 | PM | MassAction | |
PIP2DAG+IP3_145 | r32 | PM | HMMIrreversible | |
SoS_Grb2+Shc_PiShc_Pi_SoS_Grb2 | 007 | IC | MassAction | |
GluR1GluR1_845 | 106 | IC | HMMIrreversible | |
Gq_GDP+G_byGqby | r29 | PM | MassAction | |
D1R_Gaby+DaDa_D1R_Gaby | 067 | PM | MassAction | |
PKA_active+PKA_InhibitorPKA_inhibited | 088 | IC | MassAction | |
PDE4_ERK+IBMXPDE4_IBMX | r24 | IC | MassAction | |
PIP2IP3_145+DAG | r31 | PM | HMMIrreversible | |
PDE4_PKA+IBMXPDE4_IBMX | r22 | IC | MassAction | |
PLC+Gq_GTPPLC_Gq | r34 | PM | MassAction | |
Grb2+SoSSoS_Grb2 | 010 | IC | MassAction | |
DARPP32_Pi+PP1DARPP32_Pi_PP1 | r18 | IC | MassAction | |
ATPcAMP | r1 | PM | HMMIrreversible | |
ERK_activeERK_Tyr | r49 | IC | HMMIrreversible | |
GluR1_MembraneGluR1_degraded | 105 | PM | MassAction | |
MEKMEK_Ser | 034 | IC | HMMIrreversible | |
BRaf_PiBRaf | 063 | IC | HMMIrreversible | |
DARPP32_Pi_PP1PP1+DARPP32 | r47 | IC | MassAction | |
CaMKII_CaMCaMKII_286_CaM | 095 | IC | HMMIrreversible | |
Gaby+D1RD1R_Gaby | 065 | PM | MassAction | |
PDE2+IBMXPDE2_IBMX | r51 | IC | MassAction | |
MEK_SerMEK_active | 029 | IC | HMMIrreversible | |
CaM+CalciumCaM_Ca2 | 089 | IC | MassAction | |
Calcium_ERCalcium | r43 | ER_Membrane | MassAction | |
I1_Pi+PP1I1_Pi_PP1 | r53 | IC | MassAction | |
PIP2DAG+IP3_145 | r33 | PM | HMMIrreversible | |
R2C2+cAMPR2C2_cAMP | 082 | IC | MassAction | |
STEPSTEP_PKA | 040 | IC | HMMIrreversible | |
PDE4+RolipramPDE4_Rolipram | r9 | IC | MassAction | |
PDE4_ERKPDE4_ERK_PKA | 052 | IC | HMMIrreversible | |
Da+D5R_GabyDa_D5R_Gaby | 070 | PM | MassAction | |
Gq_GTPGq_GDP | r30 | PM | MassAction | |
Gaby+D5RD5R_Gaby | 069 | PM | MassAction | |
cAMPAMP | 079 | IC | HMMIrreversible | |
ATPcAMP | r4 | PM | HMMIrreversible | |
ERK_TyrERK_active | 037 | IC | HMMIrreversible | |
Ras_GTP+RafRas_Raf_active | 016 | IC | MassAction | |
Ga_GTPGa_GDP | 074 | PM | MassAction | |
CaMKII_286+CaM_Ca4CaMKII_286_CaM | 093 | IC | MassAction | |
I1_Pi_PP1PP1+I1 | r54 | IC | MassAction | |
cAMPAMP | 080 | IC | HMMIrreversible | |
Da_D1R_GabyGby+Ga_GTP+Da_D1R | 072 | PM | MassAction | |
PDE4_PKAPDE4_ERK_PKA | 049 | IC | HMMIrreversible | |
MEK+U0126MEK_inhibited | r16 | IC | MassAction | |
IP3_145IP3_14 | r39 | IC | HMMIrreversible | |
D5R+DaDa_D5R | 068 | PM | MassAction | |
PDE4PDE4_ERK | 047 | IC | HMMIrreversible | |
PDE1_CaM_Ca4+IBMXPDE1_IBMX | r5 | IC | MassAction | |
ERK_TyrERK | 044 | IC | HMMIrreversible | |
cAMP+R2C2_cAMPR2C2_cAMP2 | 083 | IC | MassAction | |
CaM_Ca2+CalciumCaM_Ca3 | 090 | IC | MassAction | |
Calcium_ERCalcium | r45 | ER_Membrane | GeneralKinetics | |
MEKMEK_Ser | 028 | IC | HMMIrreversible | |
CaMKIICaMKII_286 | 094 | IC | MassAction | |
BDNF_TrkB2BDNF_TrkB2_Pi | 003 | PM | MassAction | |
MEK_SerMEK_active | 035 | IC | HMMIrreversible | |
MEK_activeMEK_Ser | 033 | IC | HMMIrreversible | |
MEK_Ser+U0126MEK_inhibited | r14 | IC | MassAction | |
MEK_active+U0126MEK_inhibited | r15 | IC | MassAction | |
GluR1_845GluR1 | 108 | IC | HMMIrreversible | |
GluR1_845GluR1_845_818 | r57 | IC | HMMIrreversible | |
Rolipram+PDE4_ERKPDE4_Rolipram | r8 | IC | MassAction | |
PDE4_ERK_PKA+IBMXPDE4_IBMX | r23 | IC | MassAction | |
Gqby+D1LRD1LR_Gqby | r13 | PM | MassAction | |
I1_PiI1 | 061 | IC | HMMIrreversible | |
Gaby+Da_D1RDa_D1R_Gaby | 066 | PM | MassAction | |
Ras_GTPRas_GDP | 014 | IC | MassAction | |
GluR1_MembraneGluR1_Membrane_dephosphorylated1 | r17 | PM | HMMIrreversible | |
BRafBRaf_Pi | 062 | IC | HMMIrreversible | |
SERCA+CalciumSERCA_active | r42 | ER_Membrane | GeneralKinetics | |
PDE1_CaM_Ca4PDE1 | 099 | IC | MassAction | |
ATPcAMP | r25 | PM | HMMIrreversible | |
R2C2_cAMP4PKA_active+R2C_cAMP4 | 086 | IC | MassAction | |
IP3R+IP3_145IP3R_open | r41 | ER_Membrane | MassAction | |
PDE4_ERKPDE4 | 048 | IC | HMMIrreversible | |
ERK_TyrERK | 043 | IC | HMMIrreversible | |
R2C2_cAMP3+cAMPR2C2_cAMP4 | 085 | IC | MassAction | |
CaM_Ca4+CaMKIICaMKII_CaM | 092 | IC | MassAction | |
STEP_PKASTEP | 041 | IC | HMMIrreversible |
091 Universal ID's
091 Text Annotations
005 Universal ID's
005 Text Annotations
r44 Universal ID's
r44 Text Annotations
r19 Universal ID's
r19 Text Annotations
r20 Universal ID's
r20 Text Annotations
r40 Universal ID's
r40 Text Annotations
057 Universal ID's
057 Text Annotations
r28 Universal ID's
r28 Text Annotations
087 Universal ID's
087 Text Annotations
r10 Universal ID's
r10 Text Annotations
r7 Universal ID's
r7 Text Annotations
r21 Universal ID's
r21 Text Annotations
096 Universal ID's
096 Text Annotations
056 Universal ID's
056 Text Annotations
036 Universal ID's
036 Text Annotations
064 Universal ID's
064 Text Annotations
r52 Universal ID's
r52 Text Annotations
078 Universal ID's
078 Text Annotations
103 Universal ID's
103 Text Annotations
073 Universal ID's
073 Text Annotations
r38 Universal ID's
r38 Text Annotations
r12 Universal ID's
r12 Text Annotations
r6 Universal ID's
r6 Text Annotations
100 Universal ID's
100 Text Annotations
r0 Universal ID's
r0 Text Annotations
r11 Universal ID's
r11 Text Annotations
r3 Universal ID's
r3 Text Annotations
r55 Universal ID's
r55 Text Annotations
011 Universal ID's
011 Text Annotations
012 Universal ID's
012 Text Annotations
097 Universal ID's
097 Text Annotations
071 Universal ID's
071 Text Annotations
002 Universal ID's
002 Text Annotations
r35 Universal ID's
r35 Text Annotations
023 Universal ID's
023 Text Annotations
001 Universal ID's
001 Text Annotations
r36 Universal ID's
r36 Text Annotations
084 Universal ID's
084 Text Annotations
098 Universal ID's
098 Text Annotations
r26 Universal ID's
r26 Text Annotations
081 Universal ID's
081 Text Annotations
104 Universal ID's
104 Text Annotations
077 Universal ID's
077 Text Annotations
032 Universal ID's
032 Text Annotations
008 Universal ID's
008 Text Annotations
006 Universal ID's
006 Text Annotations
r27 Universal ID's
r27 Text Annotations
046 Universal ID's
046 Text Annotations
060 Universal ID's
060 Text Annotations
018 Universal ID's
018 Text Annotations
r48 Universal ID's
r48 Text Annotations
045 Universal ID's
045 Text Annotations
075 Universal ID's
075 Text Annotations
009 Universal ID's
009 Text Annotations
r50 Universal ID's
r50 Text Annotations
004 Universal ID's
004 Text Annotations
r56 Universal ID's
r56 Text Annotations
r37 Universal ID's
r37 Text Annotations
r32 Universal ID's
r32 Text Annotations
007 Universal ID's
007 Text Annotations
106 Universal ID's
106 Text Annotations
r29 Universal ID's
r29 Text Annotations
067 Universal ID's
067 Text Annotations
088 Universal ID's
088 Text Annotations
r24 Universal ID's
r24 Text Annotations
r31 Universal ID's
r31 Text Annotations
r22 Universal ID's
r22 Text Annotations
r34 Universal ID's
r34 Text Annotations
010 Universal ID's
010 Text Annotations
r18 Universal ID's
r18 Text Annotations
r1 Universal ID's
r1 Text Annotations
r49 Universal ID's
r49 Text Annotations
105 Universal ID's
105 Text Annotations
034 Universal ID's
034 Text Annotations
063 Universal ID's
063 Text Annotations
r47 Universal ID's
r47 Text Annotations
095 Universal ID's
095 Text Annotations
065 Universal ID's
065 Text Annotations
r51 Universal ID's
r51 Text Annotations
029 Universal ID's
029 Text Annotations
089 Universal ID's
089 Text Annotations
r43 Universal ID's
r43 Text Annotations
r53 Universal ID's
r53 Text Annotations
r33 Universal ID's
r33 Text Annotations
082 Universal ID's
082 Text Annotations
040 Universal ID's
040 Text Annotations
r9 Universal ID's
r9 Text Annotations
052 Universal ID's
052 Text Annotations
070 Universal ID's
070 Text Annotations
r30 Universal ID's
r30 Text Annotations
069 Universal ID's
069 Text Annotations
079 Universal ID's
079 Text Annotations
r4 Universal ID's
r4 Text Annotations
037 Universal ID's
037 Text Annotations
016 Universal ID's
016 Text Annotations
074 Universal ID's
074 Text Annotations
093 Universal ID's
093 Text Annotations
r54 Universal ID's
r54 Text Annotations
080 Universal ID's
080 Text Annotations
072 Universal ID's
072 Text Annotations
049 Universal ID's
049 Text Annotations
r16 Universal ID's
r16 Text Annotations
r39 Universal ID's
r39 Text Annotations
068 Universal ID's
068 Text Annotations
047 Universal ID's
047 Text Annotations
r5 Universal ID's
r5 Text Annotations
044 Universal ID's
044 Text Annotations
083 Universal ID's
083 Text Annotations
090 Universal ID's
090 Text Annotations
r45 Universal ID's
r45 Text Annotations
028 Universal ID's
028 Text Annotations
094 Universal ID's
094 Text Annotations
003 Universal ID's
003 Text Annotations
035 Universal ID's
035 Text Annotations
033 Universal ID's
033 Text Annotations
r14 Universal ID's
r14 Text Annotations
r15 Universal ID's
r15 Text Annotations
108 Universal ID's
108 Text Annotations
r57 Universal ID's
r57 Text Annotations
r8 Universal ID's
r8 Text Annotations
r23 Universal ID's
r23 Text Annotations
r13 Universal ID's
r13 Text Annotations
061 Universal ID's
061 Text Annotations
066 Universal ID's
066 Text Annotations
014 Universal ID's
014 Text Annotations
r17 Universal ID's
r17 Text Annotations
062 Universal ID's
062 Text Annotations
r42 Universal ID's
r42 Text Annotations
099 Universal ID's
099 Text Annotations
r25 Universal ID's
r25 Text Annotations
086 Universal ID's
086 Text Annotations
r41 Universal ID's
r41 Text Annotations
048 Universal ID's
048 Text Annotations
043 Universal ID's
043 Text Annotations
085 Universal ID's
085 Text Annotations
092 Universal ID's
092 Text Annotations
041 Universal ID's
041 Text Annotations
Expressions for 091
reaction rate
J
(((Kf * CaM_Ca3) * Calcium) - (Kr * CaM_Ca4)) [uM.s-1]
forward rate constant
Kf
0.465 [s-1.uM-1]
reverse rate constant
Kr
10.0 [s-1]
Expressions for 005
reaction rate
J
((Kf * Int_TrkB2) - (Kr * TrkB)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
forward rate constant
Kf
0.001 [s-1]
reverse rate constant
Kr
0.001 [s-1]
Expressions for r44
reaction rate
J
(Kcat * SERCA_active * Calcium * Calcium / (0.0625 + (Calcium * Calcium))) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
local
Kcat
10.0 [s-1]
Expressions for r19
reaction rate
J
(((Kf * PDE1) * IBMX) - (Kr * PDE1_IBMX)) [uM.s-1]
forward rate constant
Kf
8.0 [s-1.uM-1]
reverse rate constant
Kr
0.8 [s-1]
Expressions for r20
reaction rate
J
(((Kf * Da) * D1LR_Gqby) - (Kr * Da_D1LR_Gqby)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
forward rate constant
Kf
3.33 [s-1.uM-1]
reverse rate constant
Kr
10.0 [s-1]
Expressions for r40
reaction rate
J
((Vmax * IP3_145) / (Km + IP3_145)) [uM.s-1]
Km (1/2 max)
Km
18.0 [uM]
max reaction rate
Vmax
(Kcat * IP3_5Pase2) [uM.s-1]
local
Kcat
10.667 [s-1]
Expressions for 057
reaction rate
J
((Vmax * DARPP32_Pi) / (Km + DARPP32_Pi)) [uM.s-1]
Km (1/2 max)
Km
0.37 [uM]
max reaction rate
Vmax
(Kcat * PP2A_DI) [uM.s-1]
local
Kcat
6.7 [s-1]
Expressions for r28
reaction rate
J
((Kf * Da_D1LR_Gqby) - (((Kr * G_by) * Da_D1LR) * Gq_GTP)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
forward rate constant
Kf
20.0 [s-1]
reverse rate constant
Kr
0.0 [um4.s-1.molecules-2]
Expressions for 087
reaction rate
J
((Kf * R2C_cAMP4) - ((Kr * PKA_active) * R2_cAMP4)) [uM.s-1]
forward rate constant
Kf
60.0 [s-1]
reverse rate constant
Kr
18.0 [s-1.uM-1]
Expressions for r10
reaction rate
J
(((Kf * Rolipram) * PDE4_ERK_PKA) - (Kr * PDE4_Rolipram)) [uM.s-1]
forward rate constant
Kf
1.0 [s-1.uM-1]
reverse rate constant
Kr
0.019 [s-1]
Expressions for r7
reaction rate
J
(((Kf * AC5) * Fsk) - (Kr * AC5_Fsk)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
forward rate constant
Kf
0.026 [s-1.uM-1]
reverse rate constant
Kr
1.0 [s-1]
Expressions for r21
reaction rate
J
(((Kf * IBMX) * PDE4) - (Kr * PDE4_IBMX)) [uM.s-1]
forward rate constant
Kf
8.0 [s-1.uM-1]
reverse rate constant
Kr
0.8 [s-1]
Expressions for 096
reaction rate
J
((Vmax * CaMKII_286) / (Km + CaMKII_286)) [uM.s-1]
Km (1/2 max)
Km
5.1 [uM]
max reaction rate
Vmax
(Kcat * PP1) [uM.s-1]
local
Kcat
0.35 [s-1]
Expressions for 056
reaction rate
J
((Vmax * DARPP32) / (Km + DARPP32)) [uM.s-1]
Km (1/2 max)
Km
2.4 [uM]
max reaction rate
Vmax
(Kcat * PKA_active) [uM.s-1]
local
Kcat
2.7 [s-1]
Expressions for 036
reaction rate
J
((Vmax * ERK) / (Km + ERK)) [uM.s-1]
Km (1/2 max)
Km
0.046296 [uM]
max reaction rate
Vmax
(Kcat * MEK_active) [uM.s-1]
local
Kcat
0.15 [s-1]
Expressions for 064
reaction rate
J
(((Kf * Da) * D1R) - (Kr * Da_D1R)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
forward rate constant
Kf
1.11 [s-1.uM-1]
reverse rate constant
Kr
10.0 [s-1]
Expressions for r52
reaction rate
J
((Vmax * cAMP) / (Km + cAMP)) [uM.s-1]
Km (1/2 max)
Km
90.0 [uM]
max reaction rate
Vmax
(Kcat * PDEbg) [uM.s-1]
local
Kcat
20.0 [s-1]
Expressions for 078
reaction rate
J
((Vmax * cAMP) / (Km + cAMP)) [uM.s-1]
Km (1/2 max)
Km
1.8 [uM]
max reaction rate
Vmax
(Kcat * PDE4_ERK_PKA) [uM.s-1]
local
Kcat
8.0 [s-1]
Expressions for 103
reaction rate
J
(((Kf * Four1N) * GluR1_845_818) - (Kr * GluR1_Membrane)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
forward rate constant
Kf
0.0108 [molecules.um-2.s-1.uM-2]
reverse rate constant
Kr
0.008 [s-1]
Expressions for 073
reaction rate
J
(((Kf * Ga_GDP) * Gby) - (Kr * Gaby)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
forward rate constant
Kf
100.0 [um2.s-1.molecules-1]
reverse rate constant
Kr
0.0 [s-1]
Expressions for r38
reaction rate
J
((Kf * IP3_145) - (Kr * IP3_degraded)) [uM.s-1]
forward rate constant
Kf
2.5 [s-1]
reverse rate constant
Kr
0.0 [s-1]
Expressions for r12
reaction rate
J
((Vmax * cAMP) / (Km + cAMP)) [uM.s-1]
Km (1/2 max)
Km
0.3 [uM]
max reaction rate
Vmax
(Kcat * PDE3) [uM.s-1]
local
Kcat
30.0 [s-1]
Expressions for r6
reaction rate
J
(((Kf * PDE3) * IBMX) - (Kr * PDE3_IBMX)) [uM.s-1]
forward rate constant
Kf
8.0 [s-1.uM-1]
reverse rate constant
Kr
0.8 [s-1]
Expressions for 100
reaction rate
J
((Kf * AMPAR_Bulk) - (Kr * GluR1)) [uM.s-1]
forward rate constant
Kf
0.018 [s-1]
reverse rate constant
Kr
1.0 [s-1]
Expressions for r0
reaction rate
J
((Kf * Da_D5R_Gaby) - (((Kr * Da_D5R) * Gby) * Ga_GTP)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
forward rate constant
Kf
20.0 [s-1]
reverse rate constant
Kr
0.0 [um4.s-1.molecules-2]
Expressions for r11
reaction rate
J
(((Kf * Rolipram) * PDE4_PKA) - (Kr * PDE4_Rolipram)) [uM.s-1]
forward rate constant
Kf
1.0 [s-1.uM-1]
reverse rate constant
Kr
0.019 [s-1]
Expressions for r3
reaction rate
J
((Vmax * ATP) / (Km + ATP)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
Km (1/2 max)
Km
20.1149 [uM]
max reaction rate
Vmax
(Kcat * AC_basal) [molecules.um-2.s-1]
local
Kcat
7.0 [s-1]
Expressions for r55
reaction rate
J
((Vmax * PDE4_ERK_PKA) / (Km + PDE4_ERK_PKA)) [uM.s-1]
Km (1/2 max)
Km
8.0 [uM]
max reaction rate
Vmax
(Kcat * PP1_PDE) [uM.s-1]
local
Kcat
1.0 [s-1]
Expressions for 011
reaction rate
J
((Vmax * Shc) / (Km + Shc)) [uM.s-1]
Km (1/2 max)
Km
0.83331 [uM]
max reaction rate
Vmax
(0.3 * BDNF_TrkB2_Pi) [uM.s-1]
Expressions for 012
reaction rate
J
((Vmax * SoS) / (Km + SoS)) [uM.s-1]
Km (1/2 max)
Km
25.641 [uM]
max reaction rate
Vmax
(10.0 * ERK_active) [uM.s-1]
Expressions for 097
reaction rate
J
((Vmax * CaMKII_286_CaM) / (Km + CaMKII_286_CaM)) [uM.s-1]
Km (1/2 max)
Km
5.1 [uM]
max reaction rate
Vmax
(Kcat * PP1) [uM.s-1]
local
Kcat
0.35 [s-1]
Expressions for 071
reaction rate
J
(((Kf * Da_D5R) * Gaby) - (Kr * Da_D5R_Gaby)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
forward rate constant
Kf
0.6 [um2.s-1.molecules-1]
reverse rate constant
Kr
0.001 [s-1]
Expressions for 002
reaction rate
J
(((Kf * TrkB) * BDNF_TrkB) - (Kr * BDNF_TrkB2)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
forward rate constant
Kf
1.0 [um2.s-1.molecules-1]
reverse rate constant
Kr
0.02 [s-1]
Expressions for r35
reaction rate
J
(((Kf * PLC) * Calcium) - (Kr * PLC_Ca)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
forward rate constant
Kf
1.0 [s-1.uM-1]
reverse rate constant
Kr
1.0 [s-1]
Expressions for 023
reaction rate
J
((Vmax * Ras_GTP) / (Km + Ras_GTP)) [uM.s-1]
Km (1/2 max)
Km
1.0104 [uM]
max reaction rate
Vmax
(10.0 * Gap) [uM.s-1]
Expressions for 001
reaction rate
J
(((Kf * BDNF) * TrkB) - (Kr * BDNF_TrkB)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
forward rate constant
Kf
1.0 [s-1.uM-1]
reverse rate constant
Kr
0.05 [s-1]
Expressions for r36
reaction rate
J
((Kf * PLC_Gq) - ((Kr * Gq_GDP) * PLC)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
forward rate constant
Kf
0.094 [s-1]
reverse rate constant
Kr
0.0 [um2.s-1.molecules-1]
Expressions for 084
reaction rate
J
(((Kf * R2C2_cAMP2) * cAMP) - (Kr * R2C2_cAMP3)) [uM.s-1]
forward rate constant
Kf
75.0 [s-1.uM-1]
reverse rate constant
Kr
110.0 [s-1]
Expressions for 098
reaction rate
J
(((Kf * PDE1) * CaM_Ca4) - (Kr * PDE1_CaM_Ca4)) [uM.s-1]
forward rate constant
Kf
0.1 [s-1.uM-1]
reverse rate constant
Kr
1.0 [s-1]
Expressions for r26
reaction rate
J
(((Kf * Da) * D1LR) - (Kr * Da_D1LR)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
forward rate constant
Kf
1.11 [s-1.uM-1]
reverse rate constant
Kr
10.0 [s-1]
Expressions for 081
reaction rate
J
((Vmax * cAMP) / (Km + cAMP)) [uM.s-1]
Km (1/2 max)
Km
39.683 [uM]
max reaction rate
Vmax
(Kcat * PDE1_CaM_Ca4) [uM.s-1]
local
Kcat
10.0 [s-1]
Expressions for 104
reaction rate
J
((Kf * GluR1_Membrane_dephosphorylated1) - ((Kr * GluR1) * Four1N)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
forward rate constant
Kf
8.0E-4 [s-1]
reverse rate constant
Kr
0.0 [molecules.um-2.s-1.uM-2]
Expressions for 077
reaction rate
J
((Vmax * cAMP) / (Km + cAMP)) [uM.s-1]
Km (1/2 max)
Km
1.8 [uM]
max reaction rate
Vmax
(Kcat * PDE4) [uM.s-1]
local
Kcat
10.0 [s-1]
Expressions for 032
reaction rate
J
((Vmax * MEK_Ser) / (Km + MEK_Ser)) [uM.s-1]
Km (1/2 max)
Km
15.657 [uM]
max reaction rate
Vmax
(Kcat * PP2A) [uM.s-1]
local
Kcat
6.0 [s-1]
Expressions for 008
reaction rate
J
(((Kf * SoS_Pi) * Grb2) - (Kr * SoS_Pi_Grb2)) [uM.s-1]
forward rate constant
Kf
0.025 [s-1.uM-1]
reverse rate constant
Kr
0.0168 [s-1]
Expressions for 006
reaction rate
J
((Kf * Shc_Pi) - (Kr * Shc)) [uM.s-1]
forward rate constant
Kf
1.0E-4 [s-1]
reverse rate constant
Kr
0.0 [s-1]
Expressions for r27
reaction rate
J
(((Kf * Da_D1LR) * Gqby) - (Kr * Da_D1LR_Gqby)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
forward rate constant
Kf
0.6 [um2.s-1.molecules-1]
reverse rate constant
Kr
0.001 [s-1]
Expressions for 046
reaction rate
J
((Vmax * PDE4_PKA) / (Km + PDE4_PKA)) [uM.s-1]
Km (1/2 max)
Km
8.0 [uM]
max reaction rate
Vmax
(Kcat * PP1_PDE) [uM.s-1]
local
Kcat
5.0 [s-1]
Expressions for 060
reaction rate
J
((Vmax * I1) / (Km + I1)) [uM.s-1]
Km (1/2 max)
Km
7.5 [uM]
max reaction rate
Vmax
(Kcat * PKA_active) [uM.s-1]
local
Kcat
6.0 [s-1]
Expressions for 018
reaction rate
J
((Vmax * Ras_GDP) / (Km + Ras_GDP)) [uM.s-1]
Km (1/2 max)
Km
0.50505 [uM]
max reaction rate
Vmax
(0.2 * Shc_Pi_SoS_Grb2) [uM.s-1]
Expressions for r48
reaction rate
J
((Vmax * cAMP) / (Km + cAMP)) [uM.s-1]
Km (1/2 max)
Km
1.8 [uM]
max reaction rate
Vmax
(Kcat * PDE4_ERK) [uM.s-1]
local
Kcat
0.01 [s-1]
Expressions for 045
reaction rate
J
((Vmax * PDE4) / (Km + PDE4)) [uM.s-1]
Km (1/2 max)
Km
7.5 [uM]
max reaction rate
Vmax
(Kcat * PKA_active) [uM.s-1]
local
Kcat
3.0 [s-1]
Expressions for 075
reaction rate
J
(((Kf * Ga_GTP) * AC5) - (Kr * AC5_Ga)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
forward rate constant
Kf
38.5 [um2.s-1.molecules-1]
reverse rate constant
Kr
50.0 [s-1]
Expressions for 009
reaction rate
J
((Kf * SoS_Pi) - (Kr * SoS)) [uM.s-1]
forward rate constant
Kf
0.001 [s-1]
reverse rate constant
Kr
0.0 [s-1]
Expressions for r50
reaction rate
J
((Vmax * cAMP) / (Km + cAMP)) [uM.s-1]
Km (1/2 max)
Km
30.0 [uM]
max reaction rate
Vmax
(Kcat * PDE2) [uM.s-1]
local
Kcat
12.0 [s-1]
Expressions for 004
reaction rate
J
((Kf * BDNF_TrkB2_Pi) - (Kr * Int_TrkB2)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
forward rate constant
Kf
1.0E-4 [molecules.um-2.s-1.uM-1]
reverse rate constant
Kr
0.0 [s-1]
Expressions for r56
reaction rate
J
((Vmax * GluR1_845_818) / (Km + GluR1_845_818)) [uM.s-1]
Km (1/2 max)
Km
0.97145 [uM]
max reaction rate
Vmax
(Kcat * PP1) [uM.s-1]
local
Kcat
0.17 [s-1]
Expressions for r37
reaction rate
J
(((Kf * PLC_Gq) * Calcium) - (Kr * PLC_Ca_Gq)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
forward rate constant
Kf
30.0 [s-1.uM-1]
reverse rate constant
Kr
1.0 [s-1]
Expressions for r32
reaction rate
J
((Vmax * PIP2) / (Km + PIP2)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
Km (1/2 max)
Km
5.0 [molecules.um-2]
max reaction rate
Vmax
(Kcat * PLC_Ca_Gq) [molecules.um-2.s-1]
local
Kcat
48.0 [s-1]
Expressions for 007
reaction rate
J
(((Kf * SoS_Grb2) * Shc_Pi) - (Kr * Shc_Pi_SoS_Grb2)) [uM.s-1]
forward rate constant
Kf
0.5 [s-1.uM-1]
reverse rate constant
Kr
0.1 [s-1]
Expressions for 106
reaction rate
J
((Vmax * GluR1) / (Km + GluR1)) [uM.s-1]
Km (1/2 max)
Km
7.5002 [uM]
max reaction rate
Vmax
(Kcat * PKA_active) [uM.s-1]
local
Kcat
6.0 [s-1]
Expressions for r29
reaction rate
J
(((Kf * Gq_GDP) * G_by) - (Kr * Gqby)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
forward rate constant
Kf
100.0 [um2.s-1.molecules-1]
reverse rate constant
Kr
0.0 [s-1]
Expressions for 067
reaction rate
J
(((Kf * D1R_Gaby) * Da) - (Kr * Da_D1R_Gaby)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
forward rate constant
Kf
3.33 [s-1.uM-1]
reverse rate constant
Kr
10.0 [s-1]
Expressions for 088
reaction rate
J
(((Kf * PKA_active) * PKA_Inhibitor) - (Kr * PKA_inhibited)) [uM.s-1]
forward rate constant
Kf
60.0 [s-1.uM-1]
reverse rate constant
Kr
1.0 [s-1]
Expressions for r24
reaction rate
J
(((Kf * PDE4_ERK) * IBMX) - (Kr * PDE4_IBMX)) [uM.s-1]
forward rate constant
Kf
8.0 [s-1.uM-1]
reverse rate constant
Kr
0.8 [s-1]
Expressions for r31
reaction rate
J
((Vmax * PIP2) / (Km + PIP2)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
Km (1/2 max)
Km
5.0 [molecules.um-2]
max reaction rate
Vmax
(Kcat * PLC_Gq) [molecules.um-2.s-1]
local
Kcat
75.0 [s-1]
Expressions for r22
reaction rate
J
(((Kf * PDE4_PKA) * IBMX) - (Kr * PDE4_IBMX)) [uM.s-1]
forward rate constant
Kf
8.0 [s-1.uM-1]
reverse rate constant
Kr
0.8 [s-1]
Expressions for r34
reaction rate
J
(((Kf * PLC) * Gq_GTP) - (Kr * PLC_Gq)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
forward rate constant
Kf
0.25 [um2.s-1.molecules-1]
reverse rate constant
Kr
0.003 [s-1]
Expressions for 010
reaction rate
J
(((Kf * Grb2) * SoS) - (Kr * SoS_Grb2)) [uM.s-1]
forward rate constant
Kf
0.025 [s-1.uM-1]
reverse rate constant
Kr
0.0168 [s-1]
Expressions for r18
reaction rate
J
(((Kf * DARPP32_Pi) * PP1) - (Kr * DARPP32_Pi_PP1)) [uM.s-1]
forward rate constant
Kf
100.0 [s-1.uM-1]
reverse rate constant
Kr
0.2 [s-1]
Expressions for r1
reaction rate
J
((Vmax * ATP) / (Km + ATP)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
Km (1/2 max)
Km
315.0 [uM]
max reaction rate
Vmax
(Kcat * AC5_Ga) [molecules.um-2.s-1]
local
Kcat
8.5 [s-1]
Expressions for r49
reaction rate
J
((Vmax * ERK_active) / (Km + ERK_active)) [uM.s-1]
Km (1/2 max)
Km
0.77 [uM]
max reaction rate
Vmax
(Kcat * PP2A) [uM.s-1]
local
Kcat
0.636 [s-1]
Expressions for 105
reaction rate
J
((Kf * GluR1_Membrane) - (Kr * GluR1_degraded)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
forward rate constant
Kf
3.6E-5 [s-1]
reverse rate constant
Kr
0.0 [molecules.um-2.s-1.uM-1]
Expressions for 034
reaction rate
J
((Vmax * MEK) / (Km + MEK)) [uM.s-1]
Km (1/2 max)
Km
0.15909 [uM]
max reaction rate
Vmax
(Kcat * BRaf_Pi) [uM.s-1]
local
Kcat
0.18 [s-1]
Expressions for 063
reaction rate
J
((Vmax * BRaf_Pi) / (Km + BRaf_Pi)) [uM.s-1]
Km (1/2 max)
Km
15.657 [uM]
max reaction rate
Vmax
(Kcat * PP2A) [uM.s-1]
local
Kcat
6.0 [s-1]
Expressions for r47
reaction rate
J
((Kf * DARPP32_Pi_PP1) - ((Kr * PP1) * DARPP32)) [uM.s-1]
forward rate constant
Kf
10.0 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-1]
Expressions for 095
reaction rate
J
((Vmax * CaMKII_CaM) / (Km + CaMKII_CaM)) [uM.s-1]
Km (1/2 max)
Km
113.6 [uM]
max reaction rate
Vmax
(Kcat * CaMKII) [uM.s-1]
local
Kcat
0.5 [s-1]
Expressions for 065
reaction rate
J
(((Kf * Gaby) * D1R) - (Kr * D1R_Gaby)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
forward rate constant
Kf
0.06 [um2.s-1.molecules-1]
reverse rate constant
Kr
3.0E-4 [s-1]
Expressions for r51
reaction rate
J
(((Kf * PDE2) * IBMX) - (Kr * PDE2_IBMX)) [uM.s-1]
forward rate constant
Kf
8.0 [s-1.uM-1]
reverse rate constant
Kr
0.8 [s-1]
Expressions for 029
reaction rate
J
((Vmax * MEK_Ser) / (Km + MEK_Ser)) [uM.s-1]
Km (1/2 max)
Km
0.15909 [uM]
max reaction rate
Vmax
(0.3 * Ras_Raf_active) [uM.s-1]
Expressions for 089
reaction rate
J
(((Kf * CaM) * pow(Calcium,2.0)) - (Kr * CaM_Ca2)) [uM.s-1]
forward rate constant
Kf
72.0 [s-1.uM-2]
reverse rate constant
Kr
72.0 [s-1]
Expressions for r43
reaction rate
J
((Kf * Calcium_ER) - (Kr * Calcium)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
forward rate constant
Kf
5.34E-4 [molecules.um-2.s-1.uM-1]
reverse rate constant
Kr
5.34E-4 [molecules.um-2.s-1.uM-1]
Expressions for r53
reaction rate
J
(((Kf * I1_Pi) * PP1) - (Kr * I1_Pi_PP1)) [uM.s-1]
forward rate constant
Kf
150.0 [s-1.uM-1]
reverse rate constant
Kr
0.1 [s-1]
Expressions for r33
reaction rate
J
((Vmax * PIP2) / (Km + PIP2)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
Km (1/2 max)
Km
19.8413 [molecules.um-2]
max reaction rate
Vmax
(Kcat * PLC_Ca) [molecules.um-2.s-1]
local
Kcat
10.0 [s-1]
Expressions for 082
reaction rate
J
(((Kf * R2C2) * cAMP) - (Kr * R2C2_cAMP)) [uM.s-1]
forward rate constant
Kf
54.0 [s-1.uM-1]
reverse rate constant
Kr
33.0 [s-1]
Expressions for 040
reaction rate
J
((Vmax * STEP) / (Km + STEP)) [uM.s-1]
Km (1/2 max)
Km
25.641 [uM]
max reaction rate
Vmax
(Kcat * PKA_active) [uM.s-1]
local
Kcat
1.0 [s-1]
Expressions for r9
reaction rate
J
(((Kf * PDE4) * Rolipram) - (Kr * PDE4_Rolipram)) [uM.s-1]
forward rate constant
Kf
1.0 [s-1.uM-1]
reverse rate constant
Kr
0.019 [s-1]
Expressions for 052
reaction rate
J
((Vmax * PDE4_ERK) / (Km + PDE4_ERK)) [uM.s-1]
Km (1/2 max)
Km
7.5 [uM]
max reaction rate
Vmax
(Kcat * PKA_active) [uM.s-1]
local
Kcat
0.1 [s-1]
Expressions for 070
reaction rate
J
(((Kf * Da) * D5R_Gaby) - (Kr * Da_D5R_Gaby)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
forward rate constant
Kf
3.33 [s-1.uM-1]
reverse rate constant
Kr
1.0 [s-1]
Expressions for r30
reaction rate
J
((Kf * Gq_GTP) - (Kr * Gq_GDP)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
forward rate constant
Kf
10.0 [s-1]
reverse rate constant
Kr
0.0 [s-1]
Expressions for 069
reaction rate
J
(((Kf * Gaby) * D5R) - (Kr * D5R_Gaby)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
forward rate constant
Kf
0.06 [um2.s-1.molecules-1]
reverse rate constant
Kr
3.0E-4 [s-1]
Expressions for 079
reaction rate
J
((Vmax * cAMP) / (Km + cAMP)) [uM.s-1]
Km (1/2 max)
Km
1.8 [uM]
max reaction rate
Vmax
(Kcat * PDE4_PKA) [uM.s-1]
local
Kcat
27.0 [s-1]
Expressions for r4
reaction rate
J
((Vmax * ATP) / (Km + ATP)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
Km (1/2 max)
Km
1030.0 [uM]
max reaction rate
Vmax
(Kcat * AC5) [molecules.um-2.s-1]
local
Kcat
0.2 [s-1]
Expressions for 037
reaction rate
J
((Vmax * ERK_Tyr) / (Km + ERK_Tyr)) [uM.s-1]
Km (1/2 max)
Km
0.046296 [uM]
max reaction rate
Vmax
(Kcat * MEK_active) [uM.s-1]
local
Kcat
0.15 [s-1]
Expressions for 016
reaction rate
J
(((Kf * Ras_GTP) * Raf) - (Kr * Ras_Raf_active)) [uM.s-1]
forward rate constant
Kf
6.0 [s-1.uM-1]
reverse rate constant
Kr
1.0 [s-1]
Expressions for 074
reaction rate
J
((Kf * Ga_GTP) - (Kr * Ga_GDP)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
forward rate constant
Kf
10.0 [s-1]
reverse rate constant
Kr
0.0 [s-1]
Expressions for 093
reaction rate
J
(((Kf * CaMKII_286) * CaM_Ca4) - (Kr * CaMKII_286_CaM)) [uM.s-1]
forward rate constant
Kf
1000.0 [s-1.uM-1]
reverse rate constant
Kr
0.1 [s-1]
Expressions for r54
reaction rate
J
((Kf * I1_Pi_PP1) - ((Kr * PP1) * I1)) [uM.s-1]
forward rate constant
Kf
1.0 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-1]
Expressions for 080
reaction rate
J
((Vmax * cAMP) / (Km + cAMP)) [uM.s-1]
Km (1/2 max)
Km
39.7 [uM]
max reaction rate
Vmax
(Kcat * PDE1) [uM.s-1]
local
Kcat
1.667 [s-1]
Expressions for 072
reaction rate
J
((Kf * Da_D1R_Gaby) - (((Kr * Gby) * Ga_GTP) * Da_D1R)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
forward rate constant
Kf
20.0 [s-1]
reverse rate constant
Kr
0.0 [um4.s-1.molecules-2]
Expressions for 049
reaction rate
J
((Vmax * PDE4_PKA) / (Km + PDE4_PKA)) [uM.s-1]
Km (1/2 max)
Km
25.641 [uM]
max reaction rate
Vmax
(Kcat * ERK_active) [uM.s-1]
local
Kcat
0.1 [s-1]
Expressions for r16
reaction rate
J
(((Kf * MEK) * U0126) - (Kr * MEK_inhibited)) [uM.s-1]
forward rate constant
Kf
1.0 [s-1.uM-1]
reverse rate constant
Kr
0.03 [s-1]
Expressions for r39
reaction rate
J
((Vmax * IP3_145) / (Km + IP3_145)) [uM.s-1]
Km (1/2 max)
Km
3.0 [uM]
max reaction rate
Vmax
(Kcat * IP3_5pase1) [uM.s-1]
local
Kcat
1.1 [s-1]
Expressions for 068
reaction rate
J
(((Kf * D5R) * Da) - (Kr * Da_D5R)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
forward rate constant
Kf
1.11 [s-1.uM-1]
reverse rate constant
Kr
1.0 [s-1]
Expressions for 047
reaction rate
J
((Vmax * PDE4) / (Km + PDE4)) [uM.s-1]
Km (1/2 max)
Km
0.47 [uM]
max reaction rate
Vmax
(Kcat * ERK_active) [uM.s-1]
local
Kcat
10.0 [s-1]
Expressions for r5
reaction rate
J
(((Kf * PDE1_CaM_Ca4) * IBMX) - (Kr * PDE1_IBMX)) [uM.s-1]
forward rate constant
Kf
8.0 [s-1.uM-1]
reverse rate constant
Kr
0.8 [s-1]
Expressions for 044
reaction rate
J
((Vmax * ERK_Tyr) / (Km + ERK_Tyr)) [uM.s-1]
Km (1/2 max)
Km
9.0 [uM]
max reaction rate
Vmax
(Kcat * STEP_PKA) [uM.s-1]
local
Kcat
0.1 [s-1]
Expressions for 083
reaction rate
J
(((Kf * cAMP) * R2C2_cAMP) - (Kr * R2C2_cAMP2)) [uM.s-1]
forward rate constant
Kf
54.0 [s-1.uM-1]
reverse rate constant
Kr
33.0 [s-1]
Expressions for 090
reaction rate
J
(((Kf * CaM_Ca2) * Calcium) - (Kr * CaM_Ca3)) [uM.s-1]
forward rate constant
Kf
3.6 [s-1.uM-1]
reverse rate constant
Kr
10.0 [s-1]
Expressions for r45
reaction rate
J
(J0 * Kc * (Calcium_ER - Calcium) * IP3R_open / (Kc + Calcium)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
local
J0
0.8 [uM-1.s-1]
local
Kc
4.69 [uM]
Expressions for 028
reaction rate
J
((Vmax * MEK) / (Km + MEK)) [uM.s-1]
Km (1/2 max)
Km
0.15909 [uM]
max reaction rate
Vmax
(0.3 * Ras_Raf_active) [uM.s-1]
Expressions for 094
reaction rate
J
((Kf * CaMKII) - (Kr * CaMKII_286)) [uM.s-1]
forward rate constant
Kf
0.003 [s-1]
reverse rate constant
Kr
0.0 [s-1]
Expressions for 003
reaction rate
J
((Kf * BDNF_TrkB2) - (Kr * BDNF_TrkB2_Pi)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
forward rate constant
Kf
0.02 [s-1]
reverse rate constant
Kr
0.0 [molecules.um-2.s-1.uM-1]
Expressions for 035
reaction rate
J
((Vmax * MEK_Ser) / (Km + MEK_Ser)) [uM.s-1]
Km (1/2 max)
Km
0.15909 [uM]
max reaction rate
Vmax
(Kcat * BRaf_Pi) [uM.s-1]
local
Kcat
0.18 [s-1]
Expressions for 033
reaction rate
J
((Vmax * MEK_active) / (Km + MEK_active)) [uM.s-1]
Km (1/2 max)
Km
15.657 [uM]
max reaction rate
Vmax
(Kcat * PP2A) [uM.s-1]
local
Kcat
6.0 [s-1]
Expressions for r14
reaction rate
J
(((Kf * MEK_Ser) * U0126) - (Kr * MEK_inhibited)) [uM.s-1]
forward rate constant
Kf
1.0 [s-1.uM-1]
reverse rate constant
Kr
0.03 [s-1]
Expressions for r15
reaction rate
J
(((Kf * MEK_active) * U0126) - (Kr * MEK_inhibited)) [uM.s-1]
forward rate constant
Kf
1.0 [s-1.uM-1]
reverse rate constant
Kr
0.03 [s-1]
Expressions for 108
reaction rate
J
((Vmax * GluR1_845) / (Km + GluR1_845)) [uM.s-1]
Km (1/2 max)
Km
0.97145 [uM]
max reaction rate
Vmax
(Kcat * PP1) [uM.s-1]
local
Kcat
0.17 [s-1]
Expressions for r57
reaction rate
J
((Vmax * GluR1_845) / (Km + GluR1_845)) [uM.s-1]
Km (1/2 max)
Km
33.0 [uM]
max reaction rate
Vmax
(Kcat * PKC_active) [uM.s-1]
local
Kcat
4.0 [s-1]
Expressions for r8
reaction rate
J
(((Kf * Rolipram) * PDE4_ERK) - (Kr * PDE4_Rolipram)) [uM.s-1]
forward rate constant
Kf
1.0 [s-1.uM-1]
reverse rate constant
Kr
0.019 [s-1]
Expressions for r23
reaction rate
J
(((Kf * PDE4_ERK_PKA) * IBMX) - (Kr * PDE4_IBMX)) [uM.s-1]
forward rate constant
Kf
8.0 [s-1.uM-1]
reverse rate constant
Kr
0.8 [s-1]
Expressions for r13
reaction rate
J
(((Kf * Gqby) * D1LR) - (Kr * D1LR_Gqby)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
forward rate constant
Kf
0.06 [um2.s-1.molecules-1]
reverse rate constant
Kr
3.0E-4 [s-1]
Expressions for 061
reaction rate
J
((Vmax * I1_Pi) / (Km + I1_Pi)) [uM.s-1]
Km (1/2 max)
Km
16.0 [uM]
max reaction rate
Vmax
(Kcat * PP2A_DI) [uM.s-1]
local
Kcat
2.0 [s-1]
Expressions for 066
reaction rate
J
(((Kf * Gaby) * Da_D1R) - (Kr * Da_D1R_Gaby)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
forward rate constant
Kf
0.6 [um2.s-1.molecules-1]
reverse rate constant
Kr
0.001 [s-1]
Expressions for 014
reaction rate
J
((Kf * Ras_GTP) - (Kr * Ras_GDP)) [uM.s-1]
forward rate constant
Kf
1.0E-4 [s-1]
reverse rate constant
Kr
0.0 [s-1]
Expressions for r17
reaction rate
J
((Vmax * GluR1_Membrane) / (Km + GluR1_Membrane)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
Km (1/2 max)
Km
0.97145 [molecules.um-2]
max reaction rate
Vmax
(Kcat * PP1) [molecules.um-2.s-1]
local
Kcat
0.17 [molecules.um-2.uM-1.s-1]
Expressions for 062
reaction rate
J
((Vmax * BRaf) / (Km + BRaf)) [uM.s-1]
Km (1/2 max)
Km
7.5 [uM]
max reaction rate
Vmax
(Kcat * PKA_active) [uM.s-1]
local
Kcat
3.0 [s-1]
Expressions for r42
reaction rate
J
(SERCA / (1.0 + (2.5 / (Calcium * Calcium)) + (0.25 / Calcium))) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
Expressions for 099
reaction rate
J
((Kf * PDE1_CaM_Ca4) - (Kr * PDE1)) [uM.s-1]
forward rate constant
Kf
0.1 [s-1]
reverse rate constant
Kr
0.0 [s-1]
Expressions for r25
reaction rate
J
((Vmax * ATP) / (Km + ATP)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
Km (1/2 max)
Km
315.0 [uM]
max reaction rate
Vmax
(Kcat * AC5_Fsk) [molecules.um-2.s-1]
local
Kcat
8.5 [s-1]
Expressions for 086
reaction rate
J
((Kf * R2C2_cAMP4) - ((Kr * PKA_active) * R2C_cAMP4)) [uM.s-1]
forward rate constant
Kf
60.0 [s-1]
reverse rate constant
Kr
18.0 [s-1.uM-1]
Expressions for r41
reaction rate
J
(((Kf * IP3R) * pow(IP3_145,3.0)) - (Kr * IP3R_open)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
forward rate constant
Kf
1.0 [s-1.uM-3]
reverse rate constant
Kr
2.7 [s-1]
Expressions for 048
reaction rate
J
((Vmax * PDE4_ERK) / (Km + PDE4_ERK)) [uM.s-1]
Km (1/2 max)
Km
8.0 [uM]
max reaction rate
Vmax
(Kcat * PP1_PDE) [uM.s-1]
local
Kcat
5.0 [s-1]
Expressions for 043
reaction rate
J
((Vmax * ERK_Tyr) / (Km + ERK_Tyr)) [uM.s-1]
Km (1/2 max)
Km
0.46 [uM]
max reaction rate
Vmax
(Kcat * STEP) [uM.s-1]
local
Kcat
1.06 [s-1]
Expressions for 085
reaction rate
J
(((Kf * R2C2_cAMP3) * cAMP) - (Kr * R2C2_cAMP4)) [uM.s-1]
forward rate constant
Kf
75.0 [s-1.uM-1]
reverse rate constant
Kr
32.5 [s-1]
Expressions for 092
reaction rate
J
(((Kf * CaM_Ca4) * CaMKII) - (Kr * CaMKII_CaM)) [uM.s-1]
forward rate constant
Kf
50.0 [s-1.uM-1]
reverse rate constant
Kr
5.0 [s-1]
Expressions for 041
reaction rate
J
((Vmax * STEP_PKA) / (Km + STEP_PKA)) [uM.s-1]
Km (1/2 max)
Km
6.0 [uM]
max reaction rate
Vmax
(Kcat * PP1) [uM.s-1]
local
Kcat
5.0 [s-1]
Structures
Name | Type | Electrical |
---|---|---|
PM | Membrane | IC(+) EC(-) |
ER_Membrane | Membrane | ER(+) IC(-) |
IC | Compartment | (+) (-) |
EC | Compartment | (+) (-) |
ER | Compartment | (+) (-) |
PM Universal ID's
PM Text Annotations
ER_Membrane Universal ID's
ER_Membrane Text Annotations
IC Universal ID's
IC Text Annotations
EC Universal ID's
EC Text Annotations
ER Universal ID's
ER Text Annotations
Species
BDNF Universal ID's
BDNF Text Annotations
CaM_Ca4 Universal ID's
CaM_Ca4 Text Annotations
PDE2_IBMX Universal ID's
PDE2_IBMX Text Annotations
Gap Universal ID's
Gap Text Annotations
R2C2_cAMP3 Universal ID's
R2C2_cAMP3 Text Annotations
SoS_Pi_Grb2 Universal ID's
SoS_Pi_Grb2 Text Annotations
PDE4_ERK_PKA Universal ID's
PDE4_ERK_PKA Text Annotations
Gby Universal ID's
Gby Text Annotations
R2C2_cAMP Universal ID's
R2C2_cAMP Text Annotations
AC5_Ga Universal ID's
AC5_Ga Text Annotations
D1LR_Gqby Universal ID's
D1LR_Gqby Text Annotations
PP1 Universal ID's
PP1 Text Annotations
DARPP32_Pi_PP1 Universal ID's
DARPP32_Pi_PP1 Text Annotations
I1_Pi_PP1 Universal ID's
I1_Pi_PP1 Text Annotations
PDE4_ERK Universal ID's
PDE4_ERK Text Annotations
AMPAR_Bulk Universal ID's
AMPAR_Bulk Text Annotations
GluR1_Membrane Universal ID's
GluR1_Membrane Text Annotations
Gqby Universal ID's
Gqby Text Annotations
PLC Universal ID's
PLC Text Annotations
PLC_Ca Universal ID's
PLC_Ca Text Annotations
PLC_Ca_Gq Universal ID's
PLC_Ca_Gq Text Annotations
IP3_degraded Universal ID's
IP3_degraded Text Annotations
IP3_14 Universal ID's
IP3_14 Text Annotations
IP3R Universal ID's
IP3R Text Annotations
AC_basal Universal ID's
AC_basal Text Annotations
G_by Universal ID's
G_by Text Annotations
Gq_GDP Universal ID's
Gq_GDP Text Annotations
PKC_active Universal ID's
PKC_active Text Annotations
PP2A Universal ID's
PP2A Text Annotations
Da_D5R Universal ID's
Da_D5R Text Annotations
PP1_PDE Universal ID's
PP1_PDE Text Annotations
cAMP Universal ID's
cAMP Text Annotations
Gaby Universal ID's
Gaby Text Annotations
U0126 Universal ID's
U0126 Text Annotations
DARPP32 Universal ID's
DARPP32 Text Annotations
Rolipram Universal ID's
Rolipram Text Annotations
Da_D5R_Gaby Universal ID's
Da_D5R_Gaby Text Annotations
AC5 Universal ID's
AC5 Text Annotations
R2C_cAMP4 Universal ID's
R2C_cAMP4 Text Annotations
PDE3_IBMX Universal ID's
PDE3_IBMX Text Annotations
R2_cAMP4 Universal ID's
R2_cAMP4 Text Annotations
BDNF_TrkB Universal ID's
BDNF_TrkB Text Annotations
AC5_Fsk Universal ID's
AC5_Fsk Text Annotations
STEP_PKA Universal ID's
STEP_PKA Text Annotations
BRaf_Pi Universal ID's
BRaf_Pi Text Annotations
D1R_Gaby Universal ID's
D1R_Gaby Text Annotations
Gq_GTP Universal ID's
Gq_GTP Text Annotations
PDE1_CaM_Ca4 Universal ID's
PDE1_CaM_Ca4 Text Annotations
GluR1_845_818 Universal ID's
GluR1_845_818 Text Annotations
Raf Universal ID's
Raf Text Annotations
IBMX Universal ID's
IBMX Text Annotations
PDEbg Universal ID's
PDEbg Text Annotations
PKA_active Universal ID's
PKA_active Text Annotations
PDE1_IBMX Universal ID's
PDE1_IBMX Text Annotations
TrkB Universal ID's
TrkB Text Annotations
GluR1_degraded Universal ID's
GluR1_degraded Text Annotations
GluR1 Universal ID's
GluR1 Text Annotations
MEK_Ser Universal ID's
MEK_Ser Text Annotations
IP3R_open Universal ID's
IP3R_open Text Annotations
ERK_Tyr Universal ID's
ERK_Tyr Text Annotations
D1LR Universal ID's
D1LR Text Annotations
Da Universal ID's
Da Text Annotations
SERCA Universal ID's
SERCA Text Annotations
SERCA_active Universal ID's
SERCA_active Text Annotations
IP3_5pase1 Universal ID's
IP3_5pase1 Text Annotations
PLC_Gq Universal ID's
PLC_Gq Text Annotations
PDE4_PKA Universal ID's
PDE4_PKA Text Annotations
MEK Universal ID's
MEK Text Annotations
Ga_GDP Universal ID's
Ga_GDP Text Annotations
CaM Universal ID's
CaM Text Annotations
Fsk Universal ID's
Fsk Text Annotations
Four1N Universal ID's
Four1N Text Annotations
PDE4_IBMX Universal ID's
PDE4_IBMX Text Annotations
D5R_Gaby Universal ID's
D5R_Gaby Text Annotations
BDNF_TrkB2 Universal ID's
BDNF_TrkB2 Text Annotations
I1_Pi Universal ID's
I1_Pi Text Annotations
ERK Universal ID's
ERK Text Annotations
Ga_GTP Universal ID's
Ga_GTP Text Annotations
PDE4_Rolipram Universal ID's
PDE4_Rolipram Text Annotations
PKA_Inhibitor Universal ID's
PKA_Inhibitor Text Annotations
CaMKII_286_CaM Universal ID's
CaMKII_286_CaM Text Annotations
Ras_GDP Universal ID's
Ras_GDP Text Annotations
MEK_inhibited Universal ID's
MEK_inhibited Text Annotations
R2C2_cAMP4 Universal ID's
R2C2_cAMP4 Text Annotations
Ras_Raf_active Universal ID's
Ras_Raf_active Text Annotations
Da_D1R_Gaby Universal ID's
Da_D1R_Gaby Text Annotations
SoS_Grb2 Universal ID's
SoS_Grb2 Text Annotations
ATP Universal ID's
ATP Text Annotations
GluR1_845 Universal ID's
GluR1_845 Text Annotations
IP3_5Pase2 Universal ID's
IP3_5Pase2 Text Annotations
Shc Universal ID's
Shc Text Annotations
Ras_GTP Universal ID's
Ras_GTP Text Annotations
R2C2 Universal ID's
R2C2 Text Annotations
D1R Universal ID's
D1R Text Annotations
PIP2 Universal ID's
PIP2 Text Annotations
Da_D1LR_Gqby Universal ID's
Da_D1LR_Gqby Text Annotations
Int_TrkB2 Universal ID's
Int_TrkB2 Text Annotations
CaMKII Universal ID's
CaMKII Text Annotations
BRaf Universal ID's
BRaf Text Annotations
R2C2_cAMP2 Universal ID's
R2C2_cAMP2 Text Annotations
PDE1 Universal ID's
PDE1 Text Annotations
CaM_Ca2 Universal ID's
CaM_Ca2 Text Annotations
PDE2 Universal ID's
PDE2 Text Annotations
BDNF_TrkB2_Pi Universal ID's
BDNF_TrkB2_Pi Text Annotations
ERK_active Universal ID's
ERK_active Text Annotations
Shc_Pi Universal ID's
Shc_Pi Text Annotations
DAG Universal ID's
DAG Text Annotations
IP3_145 Universal ID's
IP3_145 Text Annotations
MEK_active Universal ID's
MEK_active Text Annotations
AMP Universal ID's
AMP Text Annotations
Grb2 Universal ID's
Grb2 Text Annotations
STEP Universal ID's
STEP Text Annotations
PDE3 Universal ID's
PDE3 Text Annotations
Calcium Universal ID's
Calcium Text Annotations
CaMKII_CaM Universal ID's
CaMKII_CaM Text Annotations
SoS Universal ID's
SoS Text Annotations
PDE4 Universal ID's
PDE4 Text Annotations
CaMKII_286 Universal ID's
CaMKII_286 Text Annotations
Da_D1R Universal ID's
Da_D1R Text Annotations
SoS_Pi Universal ID's
SoS_Pi Text Annotations
D5R Universal ID's
D5R Text Annotations
PKA_inhibited Universal ID's
PKA_inhibited Text Annotations
CaM_Ca3 Universal ID's
CaM_Ca3 Text Annotations
Calcium_ER Universal ID's
Calcium_ER Text Annotations
GluR1_Membrane_dephosphorylated1 Universal ID's
GluR1_Membrane_dephosphorylated1 Text Annotations
I1 Universal ID's
I1 Text Annotations
Da_D1LR Universal ID's
Da_D1LR Text Annotations
DARPP32_Pi Universal ID's
DARPP32_Pi Text Annotations
Shc_Pi_SoS_Grb2 Universal ID's
Shc_Pi_SoS_Grb2 Text Annotations
PP2A_DI Universal ID's
PP2A_DI Text Annotations
Applications
Name | Properties | Math Type | Annotation |
---|---|---|---|
Application0 |
Specs -
Species Specs - Reaction Simulations |
Deterministic (ODE) Compartmental |
Application0 Universal ID's
Application0 Text Annotations
Specifications (Species) - Application0 go to Simulations
Species | Initial Condition | Diffusion Constant | Structure |
---|---|---|---|
CaM_Ca4 | 0.0 [uM] | 0.0 [um2/s] | IC |
PDE2_IBMX | 0.0 [uM] | 0.0 [um2/s] | IC |
Gap | 0.01 [uM] | 1.0 [um2/s] | IC |
R2C2_cAMP3 | 0.0 [uM] | 0.0 [um2/s] | IC |
SoS_Pi_Grb2 | 0.0 [uM] | 1.0 [um2/s] | IC |
PDE4_ERK_PKA | 0.0 [uM] | 0.0 [um2/s] | IC |
R2C2_cAMP | 0.0 [uM] | 0.0 [um2/s] | IC |
PP1 | 0.25 [uM] | 0.0 [um2/s] | IC |
DARPP32_Pi_PP1 | 0.0 [uM] | 0.0 [um2/s] | IC |
I1_Pi_PP1 | 0.0 [uM] | 0.0 [um2/s] | IC |
PDE4_ERK | 0.0 [uM] | 0.0 [um2/s] | IC |
AMPAR_Bulk | 0.011111 [uM] | 0.0 [um2/s] | IC |
IP3_degraded | 0.0 [uM] | 0.0 [um2/s] | IC |
IP3_14 | 0.0 [uM] | 0.0 [um2/s] | IC |
PKC_active | 0.05 [uM] | 0.0 [um2/s] | IC |
PP2A | 0.2 [uM] | 0.0 [um2/s] | IC |
PP1_PDE | 0.1 [uM] | 0.0 [um2/s] | IC |
cAMP | 0.0 [uM] | 0.0 [um2/s] | IC |
U0126 | 0.0 [uM] | 0.0 [um2/s] | IC |
DARPP32 | 0.5 [uM] | 0.0 [um2/s] | IC |
Rolipram | 0.0 [uM] | 0.0 [um2/s] | IC |
R2C_cAMP4 | 0.0 [uM] | 0.0 [um2/s] | IC |
PDE3_IBMX | 0.0 [uM] | 0.0 [um2/s] | IC |
R2_cAMP4 | 0.0 [uM] | 0.0 [um2/s] | IC |
STEP_PKA | 0.0 [uM] | 0.0 [um2/s] | IC |
BRaf_Pi | 0.0 [uM] | 0.0 [um2/s] | IC |
PDE1_CaM_Ca4 | 0.0 [uM] | 0.0 [um2/s] | IC |
GluR1_845_818 | 0.0 [uM] | 0.0 [um2/s] | IC |
Raf | 3.0 [uM] | 1.0 [um2/s] | IC |
IBMX | 0.0 [uM] | 0.0 [um2/s] | IC |
PDEbg | 3.0 [uM] | 0.0 [um2/s] | IC |
PKA_active | 0.0 [uM] | 0.0 [um2/s] | IC |
PDE1_IBMX | 0.0 [uM] | 0.0 [um2/s] | IC |
GluR1_degraded | 0.0 [uM] | 0.0 [um2/s] | IC |
GluR1 | 0.0 [uM] | 0.0 [um2/s] | IC |
MEK_Ser | 0.0 [uM] | 1.0 [um2/s] | IC |
ERK_Tyr | 0.0 [uM] | 1.0 [um2/s] | IC |
IP3_5pase1 | 12.0 [uM] | 0.0 [um2/s] | IC |
PDE4_PKA | 0.0 [uM] | 0.0 [um2/s] | IC |
MEK | 0.18 [uM] | 1.0 [um2/s] | IC |
CaM | 2.0 [uM] | 0.0 [um2/s] | IC |
Four1N | 0.01 [uM] | 0.0 [um2/s] | IC |
PDE4_IBMX | 0.0 [uM] | 0.0 [um2/s] | IC |
I1_Pi | 0.0 [uM] | 0.0 [um2/s] | IC |
ERK | 0.36 [uM] | 1.0 [um2/s] | IC |
PDE4_Rolipram | 0.0 [uM] | 0.0 [um2/s] | IC |
PKA_Inhibitor | 0.25 [uM] | 0.0 [um2/s] | IC |
CaMKII_286_CaM | 0.0 [uM] | 0.0 [um2/s] | IC |
Ras_GDP | 3.0 [uM] | 1.0 [um2/s] | IC |
MEK_inhibited | 0.0 [uM] | 0.0 [um2/s] | IC |
R2C2_cAMP4 | 0.0 [uM] | 0.0 [um2/s] | IC |
Ras_Raf_active | 0.0 [uM] | 1.0 [um2/s] | IC |
SoS_Grb2 | 0.0 [uM] | 1.0 [um2/s] | IC |
ATP | 2000.0 [uM] | 0.0 [um2/s] | IC |
GluR1_845 | 0.0 [uM] | 0.0 [um2/s] | IC |
IP3_5Pase2 | 0.463 [uM] | 0.0 [um2/s] | IC |
Shc | 1.0 [uM] | 1.0 [um2/s] | IC |
Ras_GTP | 0.0 [uM] | 1.0 [um2/s] | IC |
R2C2 | 0.5 [uM] | 0.0 [um2/s] | IC |
CaMKII | 2.0 [uM] | 0.0 [um2/s] | IC |
BRaf | 0.18 [uM] | 0.0 [um2/s] | IC |
R2C2_cAMP2 | 0.0 [uM] | 0.0 [um2/s] | IC |
PDE1 | 1.0 [uM] | 0.0 [um2/s] | IC |
CaM_Ca2 | 0.0 [uM] | 0.0 [um2/s] | IC |
PDE2 | 1.0 [uM] | 0.0 [um2/s] | IC |
BDNF_TrkB2_Pi | 0.0 [uM] | 0.0 [um2/s] | IC |
ERK_active | 0.0 [uM] | 1.0 [um2/s] | IC |
Shc_Pi | 0.0 [uM] | 1.0 [um2/s] | IC |
IP3_145 | 0.0 [uM] | 0.0 [um2/s] | IC |
MEK_active | 0.0 [uM] | 1.0 [um2/s] | IC |
AMP | 0.0 [uM] | 0.0 [um2/s] | IC |
Grb2 | 1.0 [uM] | 1.0 [um2/s] | IC |
STEP | 0.2 [uM] | 0.0 [um2/s] | IC |
PDE3 | 0.005 [uM] | 0.0 [um2/s] | IC |
Calcium | 0.08 [uM] | 0.0 [um2/s] | IC |
CaMKII_CaM | 0.0 [uM] | 0.0 [um2/s] | IC |
SoS | 1.0 [uM] | 1.0 [um2/s] | IC |
PDE4 | 0.4 [uM] | 0.0 [um2/s] | IC |
CaMKII_286 | 0.0 [uM] | 0.0 [um2/s] | IC |
SoS_Pi | 0.0 [uM] | 1.0 [um2/s] | IC |
PKA_inhibited | 0.0 [uM] | 0.0 [um2/s] | IC |
CaM_Ca3 | 0.0 [uM] | 0.0 [um2/s] | IC |
I1 | 0.68 [uM] | 0.0 [um2/s] | IC |
DARPP32_Pi | 0.0 [uM] | 0.0 [um2/s] | IC |
Shc_Pi_SoS_Grb2 | 0.0 [uM] | 1.0 [um2/s] | IC |
PP2A_DI | 0.11111 [uM] | 0.0 [um2/s] | IC |
BDNF | 0.0 [uM] | 1.0 [um2/s] | EC |
Da | 0.0 [uM] | 0.0 [um2/s] | EC |
Fsk | 0.0 [uM] | 0.0 [um2/s] | EC |
Calcium_ER | 900.0 [uM] | 0.0 [um2/s] | ER |
Gby | 0.0 [uM] | 0.0 [um2/s] | PM |
AC5_Ga | 0.0 [uM] | 0.0 [um2/s] | PM |
D1LR_Gqby | 0.0 [uM] | 0.0 [um2/s] | PM |
GluR1_Membrane | 0.0 [uM] | 0.0 [um2/s] | PM |
Gqby | 20.0 [uM] | 0.0 [um2/s] | PM |
PLC | 20.0 [uM] | 0.0 [um2/s] | PM |
PLC_Ca | 0.0 [uM] | 0.0 [um2/s] | PM |
PLC_Ca_Gq | 0.0 [uM] | 0.0 [um2/s] | PM |
AC_basal | 11.8 [uM] | 0.0 [um2/s] | PM |
G_by | 0.0 [uM] | 0.0 [um2/s] | PM |
Gq_GDP | 0.0 [uM] | 0.0 [um2/s] | PM |
Da_D5R | 0.0 [uM] | 0.0 [um2/s] | PM |
Gaby | 100.0 [uM] | 0.0 [um2/s] | PM |
Da_D5R_Gaby | 0.0 [uM] | 0.0 [um2/s] | PM |
AC5 | 45.0 [uM] | 0.0 [um2/s] | PM |
BDNF_TrkB | 0.0 [uM] | 0.0 [um2/s] | PM |
AC5_Fsk | 0.0 [uM] | 0.0 [um2/s] | PM |
D1R_Gaby | 0.0 [uM] | 0.0 [um2/s] | PM |
Gq_GTP | 0.0 [uM] | 0.0 [um2/s] | PM |
TrkB | 200.0 [uM] | 0.0 [um2/s] | PM |
D1LR | 20.0 [uM] | 0.0 [um2/s] | PM |
PLC_Gq | 0.0 [uM] | 0.0 [um2/s] | PM |
Ga_GDP | 0.0 [uM] | 0.0 [um2/s] | PM |
D5R_Gaby | 0.0 [uM] | 0.0 [um2/s] | PM |
BDNF_TrkB2 | 0.0 [uM] | 0.0 [um2/s] | PM |
Ga_GTP | 0.0 [uM] | 0.0 [um2/s] | PM |
Da_D1R_Gaby | 0.0 [uM] | 0.0 [um2/s] | PM |
D1R | 100.0 [uM] | 0.0 [um2/s] | PM |
PIP2 | 100.0 [uM] | 0.0 [um2/s] | PM |
Da_D1LR_Gqby | 0.0 [uM] | 0.0 [um2/s] | PM |
Int_TrkB2 | 0.0 [uM] | 0.0 [um2/s] | PM |
DAG | 0.0 [uM] | 0.0 [um2/s] | PM |
Da_D1R | 0.0 [uM] | 0.0 [um2/s] | PM |
D5R | 10.0 [uM] | 0.0 [um2/s] | PM |
GluR1_Membrane_dephosphorylated1 | 0.0 [uM] | 0.0 [um2/s] | PM |
Da_D1LR | 0.0 [uM] | 0.0 [um2/s] | PM |
IP3R | 100.0 [uM] | 0.0 [um2/s] | ER_Membrane |
IP3R_open | 0.0 [uM] | 0.0 [um2/s] | ER_Membrane |
SERCA | 250.0 [uM] | 0.0 [um2/s] | ER_Membrane |
SERCA_active | 0.0 [uM] | 0.0 [um2/s] | ER_Membrane |
Specifications (Reaction) - Application0 go to Simulations
Name | Enabled? |
---|---|
091 | included |
005 | included |
r44 | included |
r19 | included |
r20 | included |
r40 | included |
057 | included |
r28 | included |
087 | included |
r10 | included |
r7 | included |
r21 | included |
096 | included |
056 | included |
036 | included |
064 | included |
r52 | included |
078 | included |
103 | included |
073 | included |
r38 | included |
r12 | included |
r6 | included |
100 | included |
r0 | included |
r11 | included |
r3 | included |
r55 | included |
011 | included |
012 | included |
097 | included |
071 | included |
002 | included |
r35 | included |
023 | included |
001 | included |
r36 | included |
084 | included |
098 | included |
r26 | included |
081 | included |
104 | included |
077 | included |
032 | included |
008 | included |
006 | included |
r27 | included |
046 | included |
060 | included |
018 | included |
r48 | included |
045 | included |
075 | included |
009 | included |
r50 | included |
004 | included |
r56 | included |
r37 | included |
r32 | included |
007 | included |
106 | included |
r29 | included |
067 | included |
088 | included |
r24 | included |
r31 | included |
r22 | included |
r34 | included |
010 | included |
r18 | included |
r1 | included |
r49 | included |
105 | included |
034 | included |
063 | included |
r47 | included |
095 | included |
065 | included |
r51 | included |
029 | included |
089 | included |
r43 | included |
r53 | included |
r33 | included |
082 | included |
040 | included |
r9 | included |
052 | included |
070 | included |
r30 | included |
069 | included |
079 | included |
r4 | included |
037 | included |
016 | included |
074 | included |
093 | included |
r54 | included |
080 | included |
072 | included |
049 | included |
r16 | included |
r39 | included |
068 | included |
047 | included |
r5 | included |
044 | included |
083 | included |
090 | included |
r45 | included |
028 | included |
094 | included |
003 | included |
035 | included |
033 | included |
r14 | included |
r15 | included |
108 | included |
r57 | included |
r8 | included |
r23 | included |
r13 | included |
061 | included |
066 | included |
014 | included |
r17 | included |
062 | included |
r42 | included |
099 | included |
r25 | included |
086 | included |
r41 | included |
048 | included |
043 | included |
085 | included |
092 | included |
041 | included |
Simulations - Application0 go to Specifications
Name | End Time | Output Options |
---|---|---|
DA0.1 | 6000.0 |
OutputTimeStep 60.0 |
DA0.1+U0126 | 5400.0 |
OutputTimeStep 60.0 |
DA0.1+Rolipram | 5400.0 |
OutputTimeStep 60.0 |
DA0.1+BDNF | 5400.0 |
OutputTimeStep 60.0 |
DA1.0 | 6000.0 |
OutputTimeStep 60.0 |
DA1.0+U0126 | 5400.0 |
OutputTimeStep 60.0 |
DA1.0+Rolipram | 5400.0 |
OutputTimeStep 60.0 |
DA1.0+BDNF | 5400.0 |
OutputTimeStep 60.0 |
Application0 Universal ID's
Application0 Text Annotations
Application0 Universal ID's
Application0 Text Annotations
Application0 Universal ID's
Application0 Text Annotations
Application0 Universal ID's
Application0 Text Annotations
Application0 Universal ID's
Application0 Text Annotations
Application0 Universal ID's
Application0 Text Annotations
Application0 Universal ID's
Application0 Text Annotations
Application0 Universal ID's
Application0 Text Annotations
Assignments
Name | Variable | Assignment Function Expression |
---|
Events
Name | Trigger Type | Variable Assignment |
---|---|---|
t3600 | on condition: 3600.0 | Da --> 0.1, U0126 --> 0.0, Rolipram --> 0.0, BDNF --> 0.0 |
t5400 | on condition: 5400.0 | IBMX --> 10.0, Fsk --> 10.0 |
Geometry non-spatial1634669173
(Origin: 0.0, 0.0, 0.0; Extent: 10.0, 10.0, 10.0 [um])
Dimension | Type | Subdomain | Adjacent Subvolumes | Size | Mapped Compartment |
---|---|---|---|---|---|
Compartmental | Compartment | ER_Membrane |
Events
Name | Variable | Rate Expression |
---|
Downloads
Model Format | Model Downloads |
---|---|
Virtual Cell Markup Language | VCML File |
PDF Report | Report |
COMBINE Archive | OMEX File |
SEDML | SEDML File |
File Format | Application Downloads |
BNGL | Application0.bngl |
SBML | Application0.sbml |
Matlab | Application0.m |
NFSim XML | Application0.xml |