ModelBricks - Model Print Page

Name - Podocyte Nested FFM model

BioModel ID - 81992349

Reaction Diagram

Physiology

Universal ID's	Text Annotations

Reactions See in Dashboard
Reaction	Name Structure	Kinetics	Depiction
BRaf_star_cellBRaf_cell	PP_deact_BRaf cell	HMMIrreversible	BRaf_star_cellBRaf_cell
		reaction rate (J): ((Vmax * BRaf_star_cell) / (Km + BRaf_star_cell))[uM.s-1] Km (1/2 max) (Km): 15.66[uM] max reaction rate (Vmax): (kcat * PP2A_cell)[uM.s-1] user defined (kcat): 6.0[s-1]
BRaf_cellBRaf_star_cell	PKA_act_BRaf cell	GeneralKinetics	BRaf_cellBRaf_star_cell
		reaction rate (J): (Vmax * BRaf_cell / (Km + BRaf_cell))[uM.s-1] user defined (Km): 1.0[uM] user defined (Vmax): (kcat * PKA_cell)[uM.s-1] user defined (kcat): 0.1[s-1]
GRK_PMGRK_cell	GRK to cytosol PM	MassAction	GRK_PMGRK_cell
		reaction rate (J): ((Kf * GRK_PM) - (Kr * GRK_cell))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 0.01[s-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-1]
Rap1_Epac_GMEpac_cAMP_cell+Rap1_GTP_GM	08: Epac exchange GM	GeneralKinetics	Rap1_Epac_GMEpac_cAMP_cell+Rap1_GTP_GM
		reaction rate (J_08__Epac_exchange): (Rap1_Epac_GM * kEpacEXCH)[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] user defined (kEpacEXCH): 0.2[s-1]
cAMP4_R2C2_cellcAMP4_R2C_cell+PKA_cell	Release of C1 cell	MassAction	cAMP4_R2C2_cellcAMP4_R2C_cell+PKA_cell
		reaction rate (J): ((Kf * cAMP4_R2C2_cell) - ((Kr * cAMP4_R2C_cell) * PKA_cell))[uM.s-1] forward rate constant (Kf): 0.6[s-1] reverse rate constant (Kr): 0.18[s-1.uM-1]
MAPKK_cellMAPKK_Ser_cell	Rap1raf_act_MAPKK GM	GeneralKinetics	MAPKK_cellMAPKK_Ser_cell
		reaction rate (J): (Vmax * MAPKK_cell / (Km + MAPKK_cell))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] user defined (Km): 0.4[uM] user defined (Vmax): (kcat * Rap1_BRaf_GM)[molecules.um-2.s-1] user defined (kcat): 0.95[s-1]
MKP1_cellMKP1p_cell	MKP1 phospho by MAPKactive cell	HMMIrreversible	MKP1_cellMKP1p_cell
		reaction rate (J): ((Vmax * MKP1_cell) / (Km + MKP1_cell))[uM.s-1] Km (1/2 max) (Km): 25.641[uM] max reaction rate (Vmax): (kcat * MAPK_active_cell)[uM.s-1] user defined (kcat): 1.0[s-1]
MKP1p_nucleus	MKP1p turnover nucleus nucleus	MassAction	MKP1p_nucleus
		reaction rate (J): (Kf * MKP1p_nucleus)[uM.s-1] forward rate constant (Kf): 1.0E-4[s-1] reverse rate constant (Kr): 0.0[uM.s-1]
cAMP_cellAMP_cell	07: PDE cell	HMMIrreversible	cAMP_cellAMP_cell
		reaction rate (J): ((Vmax_07__PDE * cAMP_cell) / (Km_07__PDE + cAMP_cell))[uM.s-1] Km (1/2 max) (Km_07__PDE): 1.3[uM] max reaction rate (Vmax_07__PDE): (kCATpde * PDE_cell)[uM.s-1] user defined (kCATpde): 8.0[s-1]
MAPK_active_nucleusMAPK_thr_nucleus	MKP1p deact MAPKact nucleus	HMMIrreversible	MAPK_active_nucleusMAPK_thr_nucleus
		reaction rate (J): ((Vmax * MAPK_active_nucleus) / (Km + MAPK_active_nucleus))[uM.s-1] Km (1/2 max) (Km): 0.0667[uM] max reaction rate (Vmax): (kcat * MKP1p_nucleus)[uM.s-1] user defined (kcat): 1.0[s-1]
MKP1_nucleus	MKP1 turnover in nucleus nucleus	MassAction	MKP1_nucleus
		reaction rate (J): (Kf * MKP1_nucleus)[uM.s-1] forward rate constant (Kf): 3.7E-4[s-1] reverse rate constant (Kr): 0.0[uM.s-1]
isoprenaline_ec+beta_PMbeta_isop_PM	01b: isoprenaline binding PM	MassAction	isoprenaline_ec+beta_PMbeta_isop_PM
		reaction rate (J): (((Kf_01b__isoprenaline_binding * isoprenaline_ec) * beta_PM) - (Kr_01b__isoprenaline_binding * beta_isop_PM))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf_01b__isoprenaline_binding): 0.1[s-1.uM-1] reverse rate constant (Kr_01b__isoprenaline_binding): 0.1[s-1]
PTPSL_star_cellPTPSL_cell	PTPSL_dephos cell	HMMIrreversible	PTPSL_star_cellPTPSL_cell
		reaction rate (J): ((Vmax * PTPSL_star_cell) / (Km + PTPSL_star_cell))[uM.s-1] Km (1/2 max) (Km): 6.0[uM] max reaction rate (Vmax): (kcat * PP1_cell)[uM.s-1] user defined (kcat): 5.0[s-1]
MAPK_Thr_cellMAPK_active_cell	MAPKK_act_MAPK_thr cell	HMMIrreversible	MAPK_Thr_cellMAPK_active_cell
		reaction rate (J): ((Vmax * MAPK_Thr_cell) / (Km + MAPK_Thr_cell))[uM.s-1] Km (1/2 max) (Km): 0.046296[uM] max reaction rate (Vmax): (0.15 * MAPKK_active_cell)[uM.s-1]
beta_P_PMbeta_PM	Receptor recycling PM	MassAction	beta_P_PMbeta_PM
		reaction rate (J): ((Kf * beta_P_PM) - (Kr * beta_PM))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 4.7E-4[s-1] reverse rate constant (Kr): 0.0[s-1]
PDE_cellPDE_star_cell	PKA_act_PDE cell	HMMIrreversible	PDE_cellPDE_star_cell
		reaction rate (J): ((Vmax * PDE_cell) / (Km + PDE_cell))[uM.s-1] Km (1/2 max) (Km): 0.5[uM] max reaction rate (Vmax): (kcat * PKA_cell)[uM.s-1] user defined (kcat): 9.0[s-1]
MAPKK_active_cellMAPKK_Ser_cell	PP2A_inact_MAPKK_active cell	HMMIrreversible	MAPKK_active_cellMAPKK_Ser_cell
		reaction rate (J): ((Vmax * MAPKK_active_cell) / (Km + MAPKK_active_cell))[uM.s-1] Km (1/2 max) (Km): 15.66[uM] max reaction rate (Vmax): (kcat * PP2A_cell)[uM.s-1] user defined (kcat): 6.0[s-1]
inhibitedPKA_cellPKI_cell+PKA_cell	PKA release by PKI cell	MassAction	inhibitedPKA_cellPKI_cell+PKA_cell
		reaction rate (J): ((Kf * inhibitedPKA_cell) - ((Kr * PKI_cell) * PKA_cell))[uM.s-1] forward rate constant (Kf): 1.0E-4[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1]
cAMP3_R2C2_cell+cAMP_cellcAMP4_R2C2_cell	cAMP_binds_A2 cell	MassAction	cAMP3_R2C2_cell+cAMP_cellcAMP4_R2C2_cell
		reaction rate (J): (((Kf * cAMP3_R2C2_cell) * cAMP_cell) - (Kr * cAMP4_R2C2_cell))[uM.s-1] forward rate constant (Kf): 75.0[s-1.uM-1] reverse rate constant (Kr): 32.5[s-1]
MAPKK_cellMAPKK_Ser_cell	BRaf_act_MAPKK cell	HMMIrreversible	MAPKK_cellMAPKK_Ser_cell
		reaction rate (J): ((Vmax * MAPKK_cell) / (Km + MAPKK_cell))[uM.s-1] Km (1/2 max) (Km): 0.159[uM] max reaction rate (Vmax): (kcat * BRaf_star_cell)[uM.s-1] user defined (kcat): 0.105[s-1]
Rap1_GDP_GM+Epac_cAMP_cellRap1_Epac_GM	8a: Rap1-Epac binding GM	MassAction	Rap1_GDP_GM+Epac_cAMP_cellRap1_Epac_GM
		reaction rate (J): (((Kf_8a__Rap1_Epac_binding * Rap1_GDP_GM) * Epac_cAMP_cell) - (Kr_8a__Rap1_Epac_binding * Rap1_Epac_GM))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf_8a__Rap1_Epac_binding): 2.0[s-1.uM-1] reverse rate constant (Kr_8a__Rap1_Epac_binding): 0.8[s-1]
cAMP_cell+Epac_cellEpac_cAMP_cell	Epac-cAMP binding cell	MassAction	cAMP_cell+Epac_cellEpac_cAMP_cell
		reaction rate (J): (((Kf_06__Epac_cAMP_binding * cAMP_cell) * Epac_cell) - (Kr_06__Epac_cAMP_binding * Epac_cAMP_cell))[uM.s-1] forward rate constant (Kf_06__Epac_cAMP_binding): 32.0[s-1.uM-1] reverse rate constant (Kr_06__Epac_cAMP_binding): 96.0[s-1]
G_bg_PM+GRK_cellGRK_Gbg_PM	GRK-Gbg binding PM	MassAction	G_bg_PM+GRK_cellGRK_Gbg_PM
		reaction rate (J): (((Kf * G_bg_PM) * GRK_cell) - (Kr * GRK_Gbg_PM))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 1.0[s-1.uM-1] reverse rate constant (Kr): 0.25[s-1]
MAPK_Thr_cellMAPK_cell	MKPp_decat_MAPKtyr cell	HMMIrreversible	MAPK_Thr_cellMAPK_cell
		reaction rate (J): ((Vmax * MAPK_Thr_cell) / (Km + MAPK_Thr_cell))[uM.s-1] Km (1/2 max) (Km): 0.067[uM] max reaction rate (Vmax): (kcat * MKP1p_cell)[uM.s-1] user defined (kcat): 1.0[s-1]
MAPK_thr_nucleusMAPK_nucleus	MKP1p deact MAPKtyr nucleus	HMMIrreversible	MAPK_thr_nucleusMAPK_nucleus
		reaction rate (J): ((Vmax * MAPK_thr_nucleus) / (Km + MAPK_thr_nucleus))[uM.s-1] Km (1/2 max) (Km): 0.0667[uM] max reaction rate (Vmax): (kcat * MKP1p_nucleus)[uM.s-1] user defined (kcat): 1.0[s-1]
Gsa_GDP_PM+G_bg_PMGs_trimer_PM	14b: Gs trimerization PM	MassAction	Gsa_GDP_PM+G_bg_PMGs_trimer_PM
		reaction rate (J): (((Kf_14b__Gs_trimerization * Gsa_GDP_PM) * G_bg_PM) - (Kr_14b__Gs_trimerization * Gs_trimer_PM))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf_14b__Gs_trimerization): 0.006[um2.s-1.molecules-1] reverse rate constant (Kr_14b__Gs_trimerization): 0.0[s-1]
PTPSL_cellPTPSL_star_cell	PKA_deact_PTPSL cell	HMMIrreversible	PTPSL_cellPTPSL_star_cell
		reaction rate (J): ((Vmax * PTPSL_cell) / (Km + PTPSL_cell))[uM.s-1] Km (1/2 max) (Km): 0.1[uM] max reaction rate (Vmax): (kcat * PKA_cell)[uM.s-1] user defined (kcat): 0.2[s-1]
CREB_nucleusCREB_Ser_nucleus	MSK_act_CREB nucleus	HMMIrreversible	CREB_nucleusCREB_Ser_nucleus
		reaction rate (J): ((Vmax * CREB_nucleus) / (Km + CREB_nucleus))[uM.s-1] Km (1/2 max) (Km): 2.0[uM] max reaction rate (Vmax): (kcat * MSK_active_nucleus)[uM.s-1] user defined (kcat): 1.5[s-1]
cAMP_cellAMP_cell	PDE_highKm deact cAMP cell	HMMIrreversible	cAMP_cellAMP_cell
		reaction rate (J): ((Vmax * cAMP_cell) / (Km + cAMP_cell))[uM.s-1] Km (1/2 max) (Km): 15.0[uM] max reaction rate (Vmax): (kcat * PDE_highKm_cell)[uM.s-1] user defined (kcat): 8.0[s-1]
MSK_active_nucleusMSK_nucleus	MSK_dephos nucleus	MassAction	MSK_active_nucleusMSK_nucleus
		reaction rate (J): ((Kf * MSK_active_nucleus) - (Kr * MSK_nucleus))[uM.s-1] forward rate constant (Kf): 0.04[s-1] reverse rate constant (Kr): 0.0[s-1]
Rap1_GDP_GMRap1_GTP_GM	constit exch+hydrolysis GM	MassAction	Rap1_GDP_GMRap1_GTP_GM
		reaction rate (J): ((Kf * Rap1_GDP_GM) - (Kr * Rap1_GTP_GM))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 3.0E-6[s-1] reverse rate constant (Kr): 8.5E-5[s-1]
CREB_nucleusCREB_Ser_nucleus	PKA_act_CREB nucleus	HMMIrreversible	CREB_nucleusCREB_Ser_nucleus
		reaction rate (J): ((Vmax * CREB_nucleus) / (Km + CREB_nucleus))[uM.s-1] Km (1/2 max) (Km): 17.0[uM] max reaction rate (Vmax): (kcat * PKA_nucleus)[uM.s-1] user defined (kcat): 6.0[s-1]
MAPK_active_cellMAPK_Thr_cell	MAPK dephosph by PTP cell	HMMIrreversible	MAPK_active_cellMAPK_Thr_cell
		reaction rate (J): ((Vmax * MAPK_active_cell) / (Km + MAPK_active_cell))[uM.s-1] Km (1/2 max) (Km): 0.5[uM] max reaction rate (Vmax): (kcat * PTPSL_cell)[uM.s-1] user defined (kcat): 1.0[s-1]
CREB_Ser_nucleusCREB_nucleus	PP1A_dephos_CREB nucleus	HMMIrreversible	CREB_Ser_nucleusCREB_nucleus
		reaction rate (J): ((Vmax * CREB_Ser_nucleus) / (Km + CREB_Ser_nucleus))[uM.s-1] Km (1/2 max) (Km): 3.0[uM] max reaction rate (Vmax): (kcatPP1A * PP1A_nucleus)[uM.s-1] user defined (kcatPP1A): 0.4[s-1]
MAPK_active_nucleusMAPK_thr_nucleus	MKP1 deact MAPKact nucleus	HMMIrreversible	MAPK_active_nucleusMAPK_thr_nucleus
		reaction rate (J): ((Vmax * MAPK_active_nucleus) / (Km + MAPK_active_nucleus))[uM.s-1] Km (1/2 max) (Km): 0.0667[uM] max reaction rate (Vmax): (kcat * MKP1_nucleus)[uM.s-1] user defined (kcat): 1.0[s-1]
MAPK_thr_nucleusMAPK_nucleus	MKP1 deact MAPKtyr nucleus	HMMIrreversible	MAPK_thr_nucleusMAPK_nucleus
		reaction rate (J): ((Vmax * MAPK_thr_nucleus) / (Km + MAPK_thr_nucleus))[uM.s-1] Km (1/2 max) (Km): 0.0667[uM] max reaction rate (Vmax): (kcat * MKP1_nucleus)[uM.s-1] user defined (kcat): 1.0[s-1]
MSK_nucleusMSK_active_nucleus	reaction2 nucleus	HMMIrreversible	MSK_nucleusMSK_active_nucleus
		reaction rate (J): ((Vmax * MSK_nucleus) / (Km + MSK_nucleus))[uM.s-1] Km (1/2 max) (Km): 25.0[uM] max reaction rate (Vmax): (10.0 * MAPK_active_nucleus)[uM.s-1]
MAPK_active_nucleusMAPK_thr_nucleus	MKP2 deact MAPKact nucleus	HMMIrreversible	MAPK_active_nucleusMAPK_thr_nucleus
		reaction rate (J): ((Vmax * MAPK_active_nucleus) / (Km + MAPK_active_nucleus))[uM.s-1] Km (1/2 max) (Km): 0.0667[uM] max reaction rate (Vmax): (kcat * MKP2_nucleus)[uM.s-1] user defined (kcat): 1.0[s-1]
cAMP_cell+cAMP2_R2C2_cellcAMP3_R2C2_cell	cAMP_bind_cAMP2R2C2 cell	MassAction	cAMP_cell+cAMP2_R2C2_cellcAMP3_R2C2_cell
		reaction rate (J): (((Kf * cAMP_cell) * cAMP2_R2C2_cell) - (Kr * cAMP3_R2C2_cell))[uM.s-1] forward rate constant (Kf): 75.0[s-1.uM-1] reverse rate constant (Kr): 110.0[s-1]
MAPK_thr_nucleusMAPK_nucleus	MKP2 deact MAPK tyr nucleus	HMMIrreversible	MAPK_thr_nucleusMAPK_nucleus
		reaction rate (J): ((Vmax * MAPK_thr_nucleus) / (Km + MAPK_thr_nucleus))[uM.s-1] Km (1/2 max) (Km): 0.0667[uM] max reaction rate (Vmax): (kcat * MKP2_nucleus)[uM.s-1] user defined (kcat): 1.0[s-1]
MKP1_nucleusMKP1p_nucleus	MKP1 phosph by MAPKactive_nucleus nucleus	HMMIrreversible	MKP1_nucleusMKP1p_nucleus
		reaction rate (J): ((Vmax * MKP1_nucleus) / (Km + MKP1_nucleus))[uM.s-1] Km (1/2 max) (Km): 25.641[uM] max reaction rate (Vmax): (kcat * MAPK_active_nucleus)[uM.s-1] user defined (kcat): 1.0[s-1]
MKP1p_nucleusMKP1_nucleus	MKP1 dephosph in nucleus nucleus	MassAction	MKP1p_nucleusMKP1_nucleus
		reaction rate (J): ((Kf * MKP1p_nucleus) - (Kr * MKP1_nucleus))[uM.s-1] forward rate constant (Kf): 1.0E-4[s-1] reverse rate constant (Kr): 0.0[s-1]
MAPK_active_cellMAPK_Thr_cell	MKP1_deact_MAPKactive cell	HMMIrreversible	MAPK_active_cellMAPK_Thr_cell
		reaction rate (J): ((Vmax * MAPK_active_cell) / (Km + MAPK_active_cell))[uM.s-1] Km (1/2 max) (Km): 0.0667[uM] max reaction rate (Vmax): (kcat * MKP1_cell)[uM.s-1] user defined (kcat): 1.0[s-1]
Gs_a_PM+AC_PMAC_Gsa_PM	04: Gs-AC binding PM	GeneralKinetics	Gs_a_PM+AC_PMAC_Gsa_PM
		reaction rate (J): ((AC_PM * Kf_04__Gs_AC_binding * Gs_a_PM) - (Kr_04__Gs_AC_binding * AC_Gsa_PM))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] user defined (Kf_04__Gs_AC_binding): 1.0[um2.molecules-1.s-1] user defined (Kr_04__Gs_AC_binding): 3.4[s-1]
ATP_cellcAMP_cell	05b: cAMP production PM	HMMIrreversible	ATP_cellcAMP_cell
		reaction rate (J): ((Vmax * ATP_cell) / (Km + ATP_cell))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] Km (1/2 max) (Km): 3.15[uM] max reaction rate (Vmax): (kcat * AC_Gsa_PM)[molecules.um-2.s-1] user defined (kcat): 8.5[s-1]
PKI_nucleus+PKA_nucleusinhibitedPKA_nucleus	PKA inhibition by PKI nucleus	MassAction	PKI_nucleus+PKA_nucleusinhibitedPKA_nucleus
		reaction rate (J): (((Kf * PKI_nucleus) * PKA_nucleus) - (Kr * inhibitedPKA_nucleus))[uM.s-1] forward rate constant (Kf): 1.0[s-1.uM-1] reverse rate constant (Kr): 1.0E-4[s-1]
R2C2_cell+cAMP_cellcAMP_R2C2_cell	cAMP bind R2C2 cell	MassAction	R2C2_cell+cAMP_cellcAMP_R2C2_cell
		reaction rate (J): (((Kf * R2C2_cell) * cAMP_cell) - (Kr * cAMP_R2C2_cell))[uM.s-1] forward rate constant (Kf): 54.0[s-1.uM-1] reverse rate constant (Kr): 33.0[s-1]
CREB_Ser_nucleusCREB_nucleus	Pp2A_deact_CREB nucleus	HMMIrreversible	CREB_Ser_nucleusCREB_nucleus
		reaction rate (J): ((Vmax * CREB_Ser_nucleus) / (Km + CREB_Ser_nucleus))[uM.s-1] Km (1/2 max) (Km): 15.66[uM] max reaction rate (Vmax): (6.0 * pp2a_nucleus)[uM.s-1]
beta_isop_PM+Gs_trimer_PMbetaAR_Gs_PM	2: ARbeta-Gs binding PM	MassAction	beta_isop_PM+Gs_trimer_PMbetaAR_Gs_PM
		reaction rate (J): (((Kf_2__ARbeta_Gs_binding * beta_isop_PM) * Gs_trimer_PM) - (Kr_2__ARbeta_Gs_binding * betaAR_Gs_PM))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf_2__ARbeta_Gs_binding): 0.01[um2.s-1.molecules-1] reverse rate constant (Kr_2__ARbeta_Gs_binding): 0.1[s-1]
MKP1gene_nucleusMKP1_RNA_nucleus	MAPK_act_MKPtranscription nucleus	HMMIrreversible	MKP1gene_nucleusMKP1_RNA_nucleus
		reaction rate (J): ((Vmax * MKP1gene_nucleus) / (Km + MKP1gene_nucleus))[uM.s-1] Km (1/2 max) (Km): 4.0[uM] max reaction rate (Vmax): (kcat * MAPK_active_nucleus)[uM.s-1] user defined (kcat): 3.0E-4[s-1]
cAMP_cellAMP_cell	PDEstar_deact_cAMP cell	HMMIrreversible	cAMP_cellAMP_cell
		reaction rate (J): ((Vmax * cAMP_cell) / (Km + cAMP_cell))[uM.s-1] Km (1/2 max) (Km): 1.3[uM] max reaction rate (Vmax): (20.0 * PDE_star_cell)[uM.s-1]
beta_isop_PMbeta_P_PM	03: GRK activity PM	GeneralKinetics	beta_isop_PMbeta_P_PM
		reaction rate (J_3__GRK_activity): ((beta_isop_PM * GRK_PM * kCATgrk / (KM + beta_isop_PM)) - (beta_P_PM * kdephos))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] user defined (KM): 250.0[molecules.um-2] user defined (kdephos): 0.0[s-1] user defined (kCATgrk): 0.204[s-1]
cAMP4_R2C_cellcAMP4_R2_cell+PKA_cell	Release of C2 cell	MassAction	cAMP4_R2C_cellcAMP4_R2_cell+PKA_cell
		reaction rate (J): ((Kf * cAMP4_R2C_cell) - ((Kr * cAMP4_R2_cell) * PKA_cell))[uM.s-1] forward rate constant (Kf): 0.6[s-1] reverse rate constant (Kr): 0.18[s-1.uM-1]
MKP1gene_nucleusMKP1_RNA_nucleus	MKP1 basal transcription nucleus	MassAction	MKP1gene_nucleusMKP1_RNA_nucleus
		reaction rate (J): ((Kf * MKP1gene_nucleus) - (Kr * MKP1_RNA_nucleus))[uM.s-1] forward rate constant (Kf): 2.0E-6[s-1] reverse rate constant (Kr): 0.0[s-1]
Rap1GAP_cell+Rap1_GTP_GMRap1_RGII_GM	10a: Rap1-RGII binding GM	MassAction	Rap1GAP_cell+Rap1_GTP_GMRap1_RGII_GM
		reaction rate (J): (((Kf_10a__Rap1_RGII_binding * Rap1GAP_cell) * Rap1_GTP_GM) - (Kr_10a__Rap1_RGII_binding * Rap1_RGII_GM))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf_10a__Rap1_RGII_binding): 0.62[s-1.uM-1] reverse rate constant (Kr_10a__Rap1_RGII_binding): 8.7[s-1]
MKP1_cell	MKP1 turnover cell	MassAction	MKP1_cell
		reaction rate (J): (Kf * MKP1_cell)[uM.s-1] forward rate constant (Kf): 3.7E-4[s-1] reverse rate constant (Kr): 0.0[uM.s-1]
cAMP_R2C2_cell+cAMP_cellcAMP2_R2C2_cell	cAMP_binds_cAMPR2C2 cell	MassAction	cAMP_R2C2_cell+cAMP_cellcAMP2_R2C2_cell
		reaction rate (J): (((Kf * cAMP_R2C2_cell) * cAMP_cell) - (Kr * cAMP2_R2C2_cell))[uM.s-1] forward rate constant (Kf): 54.0[s-1.uM-1] reverse rate constant (Kr): 33.0[s-1]
Gs_a_PMGsa_GDP_PM	Gs GTPase PM	GeneralKinetics	Gs_a_PMGsa_GDP_PM
		reaction rate (J): (Gs_a_PM * Kcat)[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] user defined (Kcat): 0.11[s-1]
Rap1_RGII_GMRap1_GDP_GM+Rap1GAP_cell	10: Rap1 GTPase GM	GeneralKinetics	Rap1_RGII_GMRap1_GDP_GM+Rap1GAP_cell
		reaction rate (J_10__Rap1_GTPase): (kcat * Rap1_RGII_GM)[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] user defined (kcat): 8.0[s-1]
MAPKK_Ser_cellMAPKK_cell	PP2A_inact_MAPKKSer cell	HMMIrreversible	MAPKK_Ser_cellMAPKK_cell
		reaction rate (J): ((Vmax * MAPKK_Ser_cell) / (Km + MAPKK_Ser_cell))[uM.s-1] Km (1/2 max) (Km): 15.66[uM] max reaction rate (Vmax): (kcat * PP2A_cell)[uM.s-1] user defined (kcat): 6.0[s-1]
MAPK_cellMAPK_Thr_cell	MAPKK_act_MAPK cell	HMMIrreversible	MAPK_cellMAPK_Thr_cell
		reaction rate (J): ((Vmax * MAPK_cell) / (Km + MAPK_cell))[uM.s-1] Km (1/2 max) (Km): 0.046296[uM] max reaction rate (Vmax): (kcat * MAPKK_active_cell)[uM.s-1] user defined (kcat): 0.15[s-1]
MKP1_RNA_cellMKP1_cell	MKP_translation cell	MassAction	MKP1_RNA_cellMKP1_cell
		reaction rate (J): ((Kf * MKP1_RNA_cell) - (Kr * MKP1_cell))[uM.s-1] forward rate constant (Kf): 0.004[s-1] reverse rate constant (Kr): 0.0[s-1]
MAPKK_Ser_cellMAPKK_active_cell	reaction1 cell	GeneralKinetics	MAPKK_Ser_cellMAPKK_active_cell
		reaction rate (J): (Vmax * MAPKK_Ser_cell / (Km + MAPKK_Ser_cell))[uM.s-1] user defined (Km): 0.159[uM] user defined (Vmax): (kcat * BRaf_star_cell)[uM.s-1] user defined (kcat): 0.105[s-1]
PDE_star_cellPDE_cell	PP2A_dephos_PDEstar cell	HMMIrreversible	PDE_star_cellPDE_cell
		reaction rate (J): ((Vmax * PDE_star_cell) / (Km + PDE_star_cell))[uM.s-1] Km (1/2 max) (Km): 0.96[uM] max reaction rate (Vmax): (0.77 * PDE_PP_cell)[uM.s-1]
GRK_Gbg_PMGRK_PM+G_bg_PM	GRK PM recruitment PM	MassAction	GRK_Gbg_PMGRK_PM+G_bg_PM
		reaction rate (J): ((Kf_GRK_PM_recruitment * GRK_Gbg_PM) - ((Kr_GRK_PM_recruitment * GRK_PM) * G_bg_PM))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf_GRK_PM_recruitment): 1.0[s-1] reverse rate constant (Kr_GRK_PM_recruitment): 1.0E-4[um2.s-1.molecules-1]
MAPK_Thr_cellMAPK_cell	reaction0 cell	HMMIrreversible	MAPK_Thr_cellMAPK_cell
		reaction rate (J): ((Vmax * MAPK_Thr_cell) / (Km + MAPK_Thr_cell))[uM.s-1] Km (1/2 max) (Km): 0.06667[uM] max reaction rate (Vmax): MKP2_cell[uM.s-1]
MAPK_active_cellMAPK_Thr_cell	reaction3 cell	HMMIrreversible	MAPK_active_cellMAPK_Thr_cell
		reaction rate (J): ((Vmax * MAPK_active_cell) / (Km + MAPK_active_cell))[uM.s-1] Km (1/2 max) (Km): 0.06667[uM] max reaction rate (Vmax): MKP2_cell[uM.s-1]
MAPK_Thr_cellMAPK_cell	MKP_decat_MAPKtyr cell	HMMIrreversible	MAPK_Thr_cellMAPK_cell
		reaction rate (J): ((Vmax * MAPK_Thr_cell) / (Km + MAPK_Thr_cell))[uM.s-1] Km (1/2 max) (Km): 0.067[uM] max reaction rate (Vmax): (kcat * MKP1_cell)[uM.s-1] user defined (kcat): 1.0[s-1]
MAPKK_Ser_cellMAPKK_active_cell	RapRaf_act_MAPKKSer GM	HMMIrreversible	MAPKK_Ser_cellMAPKK_active_cell
		reaction rate (J): ((Vmax * MAPKK_Ser_cell) / (Km + MAPKK_Ser_cell))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] Km (1/2 max) (Km): 0.4[uM] max reaction rate (Vmax): (kcat * Rap1_BRaf_GM)[molecules.um-2.s-1] user defined (kcat): 0.95[s-1]
MKP1p_cell	MKP1p turnover cell	MassAction	MKP1p_cell
		reaction rate (J): (Kf * MKP1p_cell)[uM.s-1] forward rate constant (Kf): 1.0E-4[s-1] reverse rate constant (Kr): 0.0[uM.s-1]
MKP1p_cellMKP1_cell	MKP1 dephosph cell	MassAction	MKP1p_cellMKP1_cell
		reaction rate (J): ((Kf * MKP1p_cell) - (Kr * MKP1_cell))[uM.s-1] forward rate constant (Kf): 1.0E-4[s-1] reverse rate constant (Kr): 0.0[s-1]
MAPK_active_cellMAPK_Thr_cell	MKP1p_deact_MAPKactive cell	HMMIrreversible	MAPK_active_cellMAPK_Thr_cell
		reaction rate (J): ((Vmax * MAPK_active_cell) / (Km + MAPK_active_cell))[uM.s-1] Km (1/2 max) (Km): 0.0667[uM] max reaction rate (Vmax): (kcat * MKP1p_cell)[uM.s-1] user defined (kcat): 1.0[s-1]
betaAR_Gs_PMbeta_isop_PM+Gs_a_PM+G_bg_PM	02b: Gs activation PM	MassAction	betaAR_Gs_PMbeta_isop_PM+Gs_a_PM+G_bg_PM
		reaction rate (J): ((Kf * betaAR_Gs_PM) - (((Kr * beta_isop_PM) * Gs_a_PM) * G_bg_PM))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 0.025[s-1] reverse rate constant (Kr): 0.0[um4.s-1.molecules-2]
BRaf_cell+Rap1_GTP_GMRap1_BRaf_GM	Rap1_binds_BRaf GM	MassAction	BRaf_cell+Rap1_GTP_GMRap1_BRaf_GM
		reaction rate (J): (((Kf * BRaf_cell) * Rap1_GTP_GM) - (Kr * Rap1_BRaf_GM))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 4.0[s-1.uM-1] reverse rate constant (Kr): 10.0[s-1]

Structures See in Dashboard
Name	Type Electrical (Membrane Polarity)
cell	Compartment (+) (-)

ec	Compartment (+) (-)

golgi	Compartment (+) (-)

nucleus	Compartment (+) (-)

GM	Membrane N/A

PM	Membrane N/A

nuclear membrane	Membrane N/A

Species See in Dashboard
Name	Structure	BioNetGen Definition
MSK_nucleus	nucleus

R2C2_cell	cell

ATP_cell	cell

MKP1_cell	cell

MSK_active_nucleus	nucleus

AMP_cell	cell

BRaf_cell	cell

MAPK_act_cell	cell

cAMP4_R2C2_cell	cell

cAMP4_R2C_cell	cell

cAMP4_R2_cell	cell

MAPK_nucleus	nucleus

MKP1_nucleus	nucleus

MKP2_nucleus	nucleus

MAPK_thr_nucleus	nucleus

MKP1p_cell	cell

MKP1p_nucleus	nucleus

MKP2_cell	cell

G_bg_PM	PM

Rap1_RGII_GM	GM

Gsa_GDP_PM	PM

beta_isop_PM	PM

PDE_star_cell	cell

isoprenaline_ec	ec

MKP1gene_nucleus	nucleus

PP2A_cell	cell

MAPK_active_nucleus	nucleus

cAMP_R2C2_cell	cell

Rap1_GDP_GM	GM

beta_PM	PM

Epac_cAMP_cell	cell

beta_P_PM	PM

Rap1_Epac_GM	GM

MKP1_RNA_nucleus	nucleus

cAMP2_R2C2_cell	cell

PKA_cell	cell

MAPKK_Ser_cell	cell

PKI_cell	cell

inhibitedPKA_nucleus	nucleus

inhibitedPKA_cell	cell

Gs_trimer_PM	PM

GRK_Gbg_PM	PM

Gs_a_PM	PM

MAPK_active_cell	cell

Rap1GAP_cell	cell

MAPKK_cell	cell

cAMP3_R2C2_cell	cell

cAMP_cell	cell

PP1_cell	cell

PP1A_nucleus	nucleus

CREB_Ser_nucleus	nucleus

PTPSL_star_cell	cell

Epac_cell	cell

MKP1_RNA_cell	cell

Rap1_BRaf_GM	GM

MAPKK_active_cell	cell

PKI_nucleus	nucleus

GRK_cell	cell

AC_PM	PM

AC_Gsa_PM	PM

PDE_cell	cell

Rap1_GTP_GM	GM

pp2a_nucleus	nucleus

CREB_nucleus	nucleus

PTPSL_cell	cell

MAPK_Thr_cell	cell

PDE_PP_cell	cell

PDE_highKm_cell	cell

GRK_PM	PM

betaAR_Gs_PM	PM

BRaf_star_cell	cell

PKA_nucleus	nucleus

MAPK_cell	cell

Molecules See in Dashboard
Name	Text Annotations	BioNetGen Definition

Observables See in Dashboard
Name	Type Count	BioNetGen Definition

Applications

Applications See in Dashboard
Name	Math Type	Annotation
Compart	Deterministic (ODE) Compartmental	cloned from 'Compart' owned by user eungdamr cloned from 'Compart' owned by user argh

Application - Compart

Specifications(Species) - Compart See in Dashboard
Species	Initial Condition	Diffusion Constant
R2C2_cell	0.2 [uM]	0.0 [um2/s]
ATP_cell	4000.0 [uM]	0.0 [um2/s]
MKP1_cell	3.6E-4 [uM]	0.0 [um2/s]
AMP_cell	1.0E-6 [uM]	0.0 [um2/s]
BRaf_cell	0.2 [uM]	0.0 [um2/s]
MAPK_act_cell	0.0 [uM]	0.0 [um2/s]
cAMP4_R2C2_cell	0.0 [uM]	0.0 [um2/s]
cAMP4_R2C_cell	0.0 [uM]	0.0 [um2/s]
cAMP4_R2_cell	0.0 [uM]	0.0 [um2/s]
MKP1p_cell	0.0 [uM]	0.0 [um2/s]
MKP2_cell	0.001 [uM]	0.0 [um2/s]
PDE_star_cell	0.0 [uM]	0.0 [um2/s]
PP2A_cell	0.075 [uM]	0.0 [um2/s]
cAMP_R2C2_cell	0.0 [uM]	0.0 [um2/s]
Epac_cAMP_cell	1.0E-6 [uM]	0.0 [um2/s]
cAMP2_R2C2_cell	0.0 [uM]	0.0 [um2/s]
PKA_cell	0.0 [uM]	0.0 [um2/s]
MAPKK_Ser_cell	1.0E-6 [uM]	0.0 [um2/s]
PKI_cell	0.4 [uM]	0.0 [um2/s]
inhibitedPKA_cell	0.0 [uM]	0.0 [um2/s]
MAPK_active_cell	0.0 [uM]	0.0 [um2/s]
Rap1GAP_cell	0.15 [uM]	0.0 [um2/s]
MAPKK_cell	0.18 [uM]	0.0 [um2/s]
cAMP3_R2C2_cell	0.0 [uM]	0.0 [um2/s]
cAMP_cell	1.0E-4 [uM]	0.0 [um2/s]
PP1_cell	0.04 [uM]	0.0 [um2/s]
PTPSL_star_cell	0.0 [uM]	0.0 [um2/s]
Epac_cell	0.16 [uM]	0.0 [um2/s]
MKP1_RNA_cell	4.0E-5 [uM]	0.0 [um2/s]
MAPKK_active_cell	1.0E-6 [uM]	0.0 [um2/s]
GRK_cell	0.045 [uM]	0.0 [um2/s]
PDE_cell	0.4 [uM]	0.0 [um2/s]
PTPSL_cell	0.01 [uM]	0.0 [um2/s]
MAPK_Thr_cell	0.0 [uM]	0.0 [um2/s]
PDE_PP_cell	0.2 [uM]	0.0 [um2/s]
PDE_highKm_cell	0.5 [uM]	0.0 [um2/s]
BRaf_star_cell	0.0 [uM]	0.0 [um2/s]
MAPK_cell	0.263 [uM]	0.0 [um2/s]
isoprenaline_ec	10.0 [uM]	0.0 [um2/s]
MSK_nucleus	0.1 [uM]	0.0 [um2/s]
MSK_active_nucleus	0.0 [uM]	0.0 [um2/s]
MAPK_nucleus	0.233 [uM]	0.0 [um2/s]
MKP1_nucleus	2.2E-4 [uM]	0.0 [um2/s]
MKP2_nucleus	1.0E-4 [uM]	0.0 [um2/s]
MAPK_thr_nucleus	0.0 [uM]	0.0 [um2/s]
MKP1p_nucleus	0.0 [uM]	0.0 [um2/s]
MKP1gene_nucleus	0.2 [uM]	0.0 [um2/s]
MAPK_active_nucleus	0.0 [uM]	0.0 [um2/s]
MKP1_RNA_nucleus	6.5E-7 [uM]	0.0 [um2/s]
inhibitedPKA_nucleus	0.0 [uM]	0.0 [um2/s]
PP1A_nucleus	0.04 [uM]	0.0 [um2/s]
CREB_Ser_nucleus	0.0 [uM]	0.0 [um2/s]
PKI_nucleus	0.0 [uM]	0.0 [um2/s]
pp2a_nucleus	0.05 [uM]	0.0 [um2/s]
CREB_nucleus	0.3 [uM]	0.0 [um2/s]
PKA_nucleus	0.0 [uM]	0.0 [um2/s]
Rap1_RGII_GM	0.0 [uM]	0.0 [um2/s]
Rap1_GDP_GM	100.0 [uM]	0.0 [um2/s]
Rap1_Epac_GM	0.0 [uM]	0.0 [um2/s]
Rap1_BRaf_GM	0.0 [uM]	0.0 [um2/s]
Rap1_GTP_GM	0.0 [uM]	0.0 [um2/s]
G_bg_PM	0.0 [uM]	0.0 [um2/s]
Gsa_GDP_PM	1.0E-6 [uM]	0.0 [um2/s]
beta_isop_PM	1.0E-6 [uM]	0.0 [um2/s]
beta_PM	33.0 [uM]	0.0 [um2/s]
beta_P_PM	1.0E-6 [uM]	0.0 [um2/s]
Gs_trimer_PM	100.0 [uM]	0.0 [um2/s]
GRK_Gbg_PM	0.0 [uM]	0.0 [um2/s]
Gs_a_PM	1.0E-6 [uM]	0.0 [um2/s]
AC_PM	100.0 [uM]	0.0 [um2/s]
AC_Gsa_PM	1.0E-6 [uM]	0.0 [um2/s]
GRK_PM	1.0E-6 [uM]	0.0 [um2/s]
betaAR_Gs_PM	0.0 [uM]	0.0 [um2/s]

Specifications(Reaction) - Compart See in Dashboard
Name	Reaction Mapping
PP_deact_BRaf	included
PKA_act_BRaf	included
GRK to cytosol	included
08: Epac exchange	included
Release of C1	included
Rap1raf_act_MAPKK	included
MKP1 phospho by MAPKactive	included
MKP1p turnover nucleus	included
07: PDE	included
MKP1p deact MAPKact	included
MKP1 turnover in nucleus	included
01b: isoprenaline binding	included
PTPSL_dephos	included
MAPKK_act_MAPK_thr	included
Receptor recycling	included
PKA_act_PDE	included
PP2A_inact_MAPKK_active	included
PKA release by PKI	included
cAMP_binds_A2	included
BRaf_act_MAPKK	included
8a: Rap1-Epac binding	included
Epac-cAMP binding	included
GRK-Gbg binding	included
MKPp_decat_MAPKtyr	included
MKP1p deact MAPKtyr	included
14b: Gs trimerization	included
PKA_deact_PTPSL	included
MSK_act_CREB	included
PDE_highKm deact cAMP	included
MSK_dephos	included
constit exch+hydrolysis	included
PKA_act_CREB	included
MAPK dephosph by PTP	included
PP1A_dephos_CREB	included
MKP1 deact MAPKact	included
MKP1 deact MAPKtyr	included
reaction2	included
MKP2 deact MAPKact	included
cAMP_bind_cAMP2R2C2	included
MKP2 deact MAPK tyr	included
MKP1 phosph by MAPKactive_nucleus	included
MKP1 dephosph in nucleus	included
MKP1_deact_MAPKactive	included
04: Gs-AC binding	included
05b: cAMP production	included
PKA inhibition by PKI	included
cAMP bind R2C2	included
Pp2A_deact_CREB	included
2: ARbeta-Gs binding	included
MAPK_act_MKPtranscription	included
PDEstar_deact_cAMP	included
03: GRK activity	included
Release of C2	included
MKP1 basal transcription	included
10a: Rap1-RGII binding	included
MKP1 turnover	included
cAMP_binds_cAMPR2C2	included
Gs GTPase	included
10: Rap1 GTPase	included
PP2A_inact_MAPKKSer	included
MAPKK_act_MAPK	included
MKP_translation	included
reaction1	included
PP2A_dephos_PDEstar	included
GRK PM recruitment	included
reaction0	included
reaction3	included
MKP_decat_MAPKtyr	included
RapRaf_act_MAPKKSer	included
MKP1p turnover	included
MKP1 dephosph	included
MKP1p_deact_MAPKactive	included
02b: Gs activation	included
Rap1_binds_BRaf	included
PKI translocation	included
MKP1p translocation	included
MAPK translocation	included
MKP1 translocation	included
MAPKactive_translocation	included
PKA_translocation	included
inhibited PKA export	included
MKPRNA_export	included

Simulations - Compart See in Dashboard
Name	End Time	Output Options
iso	3000.0 [s]	OutputTimes 0.0,0.01,0.02,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9,1.0,1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8,1.9,2.0,2.1,2.2,2.3,2.4,2.5,2.6,2.7,2.8,2.9,3.0,3.1,3.2,3.3,3.4,3.5,3.6,3.7,3.8,3.9,4.0,4.1,4.2,4.3,4.4,4.5,4.6,4.7,4.8,4.9,5.0,6.0,7.0,8.0,9.0,10.0,11.0,12.0,13.0,14.0,15.0,16.0,17.0,18.0,19.0,20.0,21.0,22.0,23.0,24.0,25.0,26.0,27.0,28.0,29.0,30.0,31.0,32.0,33.0,34.0,35.0,36.0,37.0,38.0,39.0,40.0,41.0,42.0,43.0,44.0,45.0,46.0,47.0,48.0,49.0,50.0,51.0,52.0,53.0,54.0,55.0,56.0,57.0,58.0,59.0,60.0,65.0,70.0,75.0,80.0,85.0,90.0,95.0,100.0,105.0,110.0,115.0,120.0,125.0,130.0,135.0,140.0,145.0,150.0,155.0,160.0,165.0,170.0,175.0,180.0,185.0,190.0,195.0,200.0,205.0,210.0,215.0,220.0,225.0,230.0,235.0,240.0,245.0,250.0,255.0,260.0,265.0,270.0,275.0,280.0,285.0,290.0,295.0,300.0,330.0,360.0,390.0,420.0,450.0,480.0,510.0,540.0,570.0,600.0,630.0,660.0,690.0,720.0,750.0,780.0,810.0,840.0,870.0,900.0,930.0,960.0,990.0,1020.0,1050.0,1080.0,1110.0,1140.0,1170.0,1200.0,1230.0,1260.0,1290.0,1320.0,1350.0,1380.0,1410.0,1440.0,1470.0,1500.0,1530.0,1560.0,1590.0,1620.0,1650.0,1680.0,1710.0,1740.0,1770.0,1800.0,1830.0,1860.0,1890.0,1920.0,1950.0,1980.0,2010.0,2040.0,2070.0,2100.0,2130.0,2160.0,2190.0,2220.0,2250.0,2280.0,2310.0,2340.0,2370.0,2400.0,2430.0,2460.0,2490.0,2520.0,2550.0,2580.0,2610.0,2640.0,2670.0,2700.0,2730.0,2760.0,2790.0,2820.0,2850.0,2880.0,2910.0,2940.0,2970.0,3000.0
rpcamp	3000.0 [s]	OutputTimes 0.0,0.01,0.02,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9,1.0,1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8,1.9,2.0,2.1,2.2,2.3,2.4,2.5,2.6,2.7,2.8,2.9,3.0,3.1,3.2,3.3,3.4,3.5,3.6,3.7,3.8,3.9,4.0,4.1,4.2,4.3,4.4,4.5,4.6,4.7,4.8,4.9,5.0,6.0,7.0,8.0,9.0,10.0,11.0,12.0,13.0,14.0,15.0,16.0,17.0,18.0,19.0,20.0,21.0,22.0,23.0,24.0,25.0,26.0,27.0,28.0,29.0,30.0,31.0,32.0,33.0,34.0,35.0,36.0,37.0,38.0,39.0,40.0,41.0,42.0,43.0,44.0,45.0,46.0,47.0,48.0,49.0,50.0,51.0,52.0,53.0,54.0,55.0,56.0,57.0,58.0,59.0,60.0,65.0,70.0,75.0,80.0,85.0,90.0,95.0,100.0,105.0,110.0,115.0,120.0,125.0,130.0,135.0,140.0,145.0,150.0,155.0,160.0,165.0,170.0,175.0,180.0,185.0,190.0,195.0,200.0,205.0,210.0,215.0,220.0,225.0,230.0,235.0,240.0,245.0,250.0,255.0,260.0,265.0,270.0,275.0,280.0,285.0,290.0,295.0,300.0,330.0,360.0,390.0,420.0,450.0,480.0,510.0,540.0,570.0,600.0,630.0,660.0,690.0,720.0,750.0,780.0,810.0,840.0,870.0,900.0,930.0,960.0,990.0,1020.0,1050.0,1080.0,1110.0,1140.0,1170.0,1200.0,1230.0,1260.0,1290.0,1320.0,1350.0,1380.0,1410.0,1440.0,1470.0,1500.0,1530.0,1560.0,1590.0,1620.0,1650.0,1680.0,1710.0,1740.0,1770.0,1800.0,1830.0,1860.0,1890.0,1920.0,1950.0,1980.0,2010.0,2040.0,2070.0,2100.0,2130.0,2160.0,2190.0,2220.0,2250.0,2280.0,2310.0,2340.0,2370.0,2400.0,2430.0,2460.0,2490.0,2520.0,2550.0,2580.0,2610.0,2640.0,2670.0,2700.0,2730.0,2760.0,2790.0,2820.0,2850.0,2880.0,2910.0,2940.0,2970.0,3000.0
U0126	3000.0 [s]	OutputTimes 0.0,0.01,0.02,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9,1.0,1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8,1.9,2.0,2.1,2.2,2.3,2.4,2.5,2.6,2.7,2.8,2.9,3.0,3.1,3.2,3.3,3.4,3.5,3.6,3.7,3.8,3.9,4.0,4.1,4.2,4.3,4.4,4.5,4.6,4.7,4.8,4.9,5.0,6.0,7.0,8.0,9.0,10.0,11.0,12.0,13.0,14.0,15.0,16.0,17.0,18.0,19.0,20.0,21.0,22.0,23.0,24.0,25.0,26.0,27.0,28.0,29.0,30.0,31.0,32.0,33.0,34.0,35.0,36.0,37.0,38.0,39.0,40.0,41.0,42.0,43.0,44.0,45.0,46.0,47.0,48.0,49.0,50.0,51.0,52.0,53.0,54.0,55.0,56.0,57.0,58.0,59.0,60.0,65.0,70.0,75.0,80.0,85.0,90.0,95.0,100.0,105.0,110.0,115.0,120.0,125.0,130.0,135.0,140.0,145.0,150.0,155.0,160.0,165.0,170.0,175.0,180.0,185.0,190.0,195.0,200.0,205.0,210.0,215.0,220.0,225.0,230.0,235.0,240.0,245.0,250.0,255.0,260.0,265.0,270.0,275.0,280.0,285.0,290.0,295.0,300.0,330.0,360.0,390.0,420.0,450.0,480.0,510.0,540.0,570.0,600.0,630.0,660.0,690.0,720.0,750.0,780.0,810.0,840.0,870.0,900.0,930.0,960.0,990.0,1020.0,1050.0,1080.0,1110.0,1140.0,1170.0,1200.0,1230.0,1260.0,1290.0,1320.0,1350.0,1380.0,1410.0,1440.0,1470.0,1500.0,1530.0,1560.0,1590.0,1620.0,1650.0,1680.0,1710.0,1740.0,1770.0,1800.0,1830.0,1860.0,1890.0,1920.0,1950.0,1980.0,2010.0,2040.0,2070.0,2100.0,2130.0,2160.0,2190.0,2220.0,2250.0,2280.0,2310.0,2340.0,2370.0,2400.0,2430.0,2460.0,2490.0,2520.0,2550.0,2580.0,2610.0,2640.0,2670.0,2700.0,2730.0,2760.0,2790.0,2820.0,2850.0,2880.0,2910.0,2940.0,2970.0,3000.0
baseline	30000.0 [s]	OutputTimes 0.0,0.01,0.02,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9,1.0,1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8,1.9,2.0,2.1,2.2,2.3,2.4,2.5,2.6,2.7,2.8,2.9,3.0,3.1,3.2,3.3,3.4,3.5,3.6,3.7,3.8,3.9,4.0,4.1,4.2,4.3,4.4,4.5,4.6,4.7,4.8,4.9,5.0,6.0,7.0,8.0,9.0,10.0,11.0,12.0,13.0,14.0,15.0,16.0,17.0,18.0,19.0,20.0,21.0,22.0,23.0,24.0,25.0,26.0,27.0,28.0,29.0,30.0,31.0,32.0,33.0,34.0,35.0,36.0,37.0,38.0,39.0,40.0,41.0,42.0,43.0,44.0,45.0,46.0,47.0,48.0,49.0,50.0,51.0,52.0,53.0,54.0,55.0,56.0,57.0,58.0,59.0,60.0,65.0,70.0,75.0,80.0,85.0,90.0,95.0,100.0,105.0,110.0,115.0,120.0,125.0,130.0,135.0,140.0,145.0,150.0,155.0,160.0,165.0,170.0,175.0,180.0,185.0,190.0,195.0,200.0,205.0,210.0,215.0,220.0,225.0,230.0,235.0,240.0,245.0,250.0,255.0,260.0,265.0,270.0,275.0,280.0,285.0,290.0,295.0,300.0,330.0,360.0,390.0,420.0,450.0,480.0,510.0,540.0,570.0,600.0,630.0,660.0,690.0,720.0,750.0,780.0,810.0,840.0,870.0,900.0,930.0,960.0,990.0,1020.0,1050.0,1080.0,1110.0,1140.0,1170.0,1200.0,1230.0,1260.0,1290.0,1320.0,1350.0,1380.0,1410.0,1440.0,1470.0,1500.0,1530.0,1560.0,1590.0,1620.0,1650.0,1680.0,1710.0,1740.0,1770.0,1800.0,1830.0,1860.0,1890.0,1920.0,1950.0,1980.0,2010.0,2040.0,2070.0,2100.0,2130.0,2160.0,2190.0,2220.0,2250.0,2280.0,2310.0,2340.0,2370.0,2400.0,2430.0,2460.0,2490.0,2520.0,2550.0,2580.0,2610.0,2640.0,2670.0,2700.0,2730.0,2760.0,2790.0,2820.0,2850.0,2880.0,2910.0,2940.0,2970.0,3000.0
Rolipram + U0216	3000.0 [s]	OutputTimes 0.0,0.01,0.02,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9,1.0,1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8,1.9,2.0,2.1,2.2,2.3,2.4,2.5,2.6,2.7,2.8,2.9,3.0,3.1,3.2,3.3,3.4,3.5,3.6,3.7,3.8,3.9,4.0,4.1,4.2,4.3,4.4,4.5,4.6,4.7,4.8,4.9,5.0,6.0,7.0,8.0,9.0,10.0,11.0,12.0,13.0,14.0,15.0,16.0,17.0,18.0,19.0,20.0,21.0,22.0,23.0,24.0,25.0,26.0,27.0,28.0,29.0,30.0,31.0,32.0,33.0,34.0,35.0,36.0,37.0,38.0,39.0,40.0,41.0,42.0,43.0,44.0,45.0,46.0,47.0,48.0,49.0,50.0,51.0,52.0,53.0,54.0,55.0,56.0,57.0,58.0,59.0,60.0,65.0,70.0,75.0,80.0,85.0,90.0,95.0,100.0,105.0,110.0,115.0,120.0,125.0,130.0,135.0,140.0,145.0,150.0,155.0,160.0,165.0,170.0,175.0,180.0,185.0,190.0,195.0,200.0,205.0,210.0,215.0,220.0,225.0,230.0,235.0,240.0,245.0,250.0,255.0,260.0,265.0,270.0,275.0,280.0,285.0,290.0,295.0,300.0,330.0,360.0,390.0,420.0,450.0,480.0,510.0,540.0,570.0,600.0,630.0,660.0,690.0,720.0,750.0,780.0,810.0,840.0,870.0,900.0,930.0,960.0,990.0,1020.0,1050.0,1080.0,1110.0,1140.0,1170.0,1200.0,1230.0,1260.0,1290.0,1320.0,1350.0,1380.0,1410.0,1440.0,1470.0,1500.0,1530.0,1560.0,1590.0,1620.0,1650.0,1680.0,1710.0,1740.0,1770.0,1800.0,1830.0,1860.0,1890.0,1920.0,1950.0,1980.0,2010.0,2040.0,2070.0,2100.0,2130.0,2160.0,2190.0,2220.0,2250.0,2280.0,2310.0,2340.0,2370.0,2400.0,2430.0,2460.0,2490.0,2520.0,2550.0,2580.0,2610.0,2640.0,2670.0,2700.0,2730.0,2760.0,2790.0,2820.0,2850.0,2880.0,2910.0,2940.0,2970.0,3000.0
Rolipram2	3000.0 [s]	OutputTimes 0.0,0.01,0.02,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9,1.0,1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8,1.9,2.0,2.1,2.2,2.3,2.4,2.5,2.6,2.7,2.8,2.9,3.0,3.1,3.2,3.3,3.4,3.5,3.6,3.7,3.8,3.9,4.0,4.1,4.2,4.3,4.4,4.5,4.6,4.7,4.8,4.9,5.0,6.0,7.0,8.0,9.0,10.0,11.0,12.0,13.0,14.0,15.0,16.0,17.0,18.0,19.0,20.0,21.0,22.0,23.0,24.0,25.0,26.0,27.0,28.0,29.0,30.0,31.0,32.0,33.0,34.0,35.0,36.0,37.0,38.0,39.0,40.0,41.0,42.0,43.0,44.0,45.0,46.0,47.0,48.0,49.0,50.0,51.0,52.0,53.0,54.0,55.0,56.0,57.0,58.0,59.0,60.0,65.0,70.0,75.0,80.0,85.0,90.0,95.0,100.0,105.0,110.0,115.0,120.0,125.0,130.0,135.0,140.0,145.0,150.0,155.0,160.0,165.0,170.0,175.0,180.0,185.0,190.0,195.0,200.0,205.0,210.0,215.0,220.0,225.0,230.0,235.0,240.0,245.0,250.0,255.0,260.0,265.0,270.0,275.0,280.0,285.0,290.0,295.0,300.0,330.0,360.0,390.0,420.0,450.0,480.0,510.0,540.0,570.0,600.0,630.0,660.0,690.0,720.0,750.0,780.0,810.0,840.0,870.0,900.0,930.0,960.0,990.0,1020.0,1050.0,1080.0,1110.0,1140.0,1170.0,1200.0,1230.0,1260.0,1290.0,1320.0,1350.0,1380.0,1410.0,1440.0,1470.0,1500.0,1530.0,1560.0,1590.0,1620.0,1650.0,1680.0,1710.0,1740.0,1770.0,1800.0,1830.0,1860.0,1890.0,1920.0,1950.0,1980.0,2010.0,2040.0,2070.0,2100.0,2130.0,2160.0,2190.0,2220.0,2250.0,2280.0,2310.0,2340.0,2370.0,2400.0,2430.0,2460.0,2490.0,2520.0,2550.0,2580.0,2610.0,2640.0,2670.0,2700.0,2730.0,2760.0,2790.0,2820.0,2850.0,2880.0,2910.0,2940.0,2970.0,3000.0
Copy of iso	3000.0 [s]	OutputTimes 0.0,0.01,0.02,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9,1.0,1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8,1.9,2.0,2.1,2.2,2.3,2.4,2.5,2.6,2.7,2.8,2.9,3.0,3.1,3.2,3.3,3.4,3.5,3.6,3.7,3.8,3.9,4.0,4.1,4.2,4.3,4.4,4.5,4.6,4.7,4.8,4.9,5.0,6.0,7.0,8.0,9.0,10.0,11.0,12.0,13.0,14.0,15.0,16.0,17.0,18.0,19.0,20.0,21.0,22.0,23.0,24.0,25.0,26.0,27.0,28.0,29.0,30.0,31.0,32.0,33.0,34.0,35.0,36.0,37.0,38.0,39.0,40.0,41.0,42.0,43.0,44.0,45.0,46.0,47.0,48.0,49.0,50.0,51.0,52.0,53.0,54.0,55.0,56.0,57.0,58.0,59.0,60.0,65.0,70.0,75.0,80.0,85.0,90.0,95.0,100.0,105.0,110.0,115.0,120.0,125.0,130.0,135.0,140.0,145.0,150.0,155.0,160.0,165.0,170.0,175.0,180.0,185.0,190.0,195.0,200.0,205.0,210.0,215.0,220.0,225.0,230.0,235.0,240.0,245.0,250.0,255.0,260.0,265.0,270.0,275.0,280.0,285.0,290.0,295.0,300.0,330.0,360.0,390.0,420.0,450.0,480.0,510.0,540.0,570.0,600.0,630.0,660.0,690.0,720.0,750.0,780.0,810.0,840.0,870.0,900.0,930.0,960.0,990.0,1020.0,1050.0,1080.0,1110.0,1140.0,1170.0,1200.0,1230.0,1260.0,1290.0,1320.0,1350.0,1380.0,1410.0,1440.0,1470.0,1500.0,1530.0,1560.0,1590.0,1620.0,1650.0,1680.0,1710.0,1740.0,1770.0,1800.0,1830.0,1860.0,1890.0,1920.0,1950.0,1980.0,2010.0,2040.0,2070.0,2100.0,2130.0,2160.0,2190.0,2220.0,2250.0,2280.0,2310.0,2340.0,2370.0,2400.0,2430.0,2460.0,2490.0,2520.0,2550.0,2580.0,2610.0,2640.0,2670.0,2700.0,2730.0,2760.0,2790.0,2820.0,2850.0,2880.0,2910.0,2940.0,2970.0,3000.0
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Copy of iso 3	3000.0 [s]	OutputTimes 0.0,0.01,0.02,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9,1.0,1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8,1.9,2.0,2.1,2.2,2.3,2.4,2.5,2.6,2.7,2.8,2.9,3.0,3.1,3.2,3.3,3.4,3.5,3.6,3.7,3.8,3.9,4.0,4.1,4.2,4.3,4.4,4.5,4.6,4.7,4.8,4.9,5.0,6.0,7.0,8.0,9.0,10.0,11.0,12.0,13.0,14.0,15.0,16.0,17.0,18.0,19.0,20.0,21.0,22.0,23.0,24.0,25.0,26.0,27.0,28.0,29.0,30.0,31.0,32.0,33.0,34.0,35.0,36.0,37.0,38.0,39.0,40.0,41.0,42.0,43.0,44.0,45.0,46.0,47.0,48.0,49.0,50.0,51.0,52.0,53.0,54.0,55.0,56.0,57.0,58.0,59.0,60.0,65.0,70.0,75.0,80.0,85.0,90.0,95.0,100.0,105.0,110.0,115.0,120.0,125.0,130.0,135.0,140.0,145.0,150.0,155.0,160.0,165.0,170.0,175.0,180.0,185.0,190.0,195.0,200.0,205.0,210.0,215.0,220.0,225.0,230.0,235.0,240.0,245.0,250.0,255.0,260.0,265.0,270.0,275.0,280.0,285.0,290.0,295.0,300.0,330.0,360.0,390.0,420.0,450.0,480.0,510.0,540.0,570.0,600.0,630.0,660.0,690.0,720.0,750.0,780.0,810.0,840.0,870.0,900.0,930.0,960.0,990.0,1020.0,1050.0,1080.0,1110.0,1140.0,1170.0,1200.0,1230.0,1260.0,1290.0,1320.0,1350.0,1380.0,1410.0,1440.0,1470.0,1500.0,1530.0,1560.0,1590.0,1620.0,1650.0,1680.0,1710.0,1740.0,1770.0,1800.0,1830.0,1860.0,1890.0,1920.0,1950.0,1980.0,2010.0,2040.0,2070.0,2100.0,2130.0,2160.0,2190.0,2220.0,2250.0,2280.0,2310.0,2340.0,2370.0,2400.0,2430.0,2460.0,2490.0,2520.0,2550.0,2580.0,2610.0,2640.0,2670.0,2700.0,2730.0,2760.0,2790.0,2820.0,2850.0,2880.0,2910.0,2940.0,2970.0,3000.0
Removal of EPAC	2700.0 [s]	OutputTimes 0.0,0.01,0.02,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9,1.0,1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8,1.9,2.0,2.1,2.2,2.3,2.4,2.5,2.6,2.7,2.8,2.9,3.0,3.1,3.2,3.3,3.4,3.5,3.6,3.7,3.8,3.9,4.0,4.1,4.2,4.3,4.4,4.5,4.6,4.7,4.8,4.9,5.0,6.0,7.0,8.0,9.0,10.0,11.0,12.0,13.0,14.0,15.0,16.0,17.0,18.0,19.0,20.0,21.0,22.0,23.0,24.0,25.0,26.0,27.0,28.0,29.0,30.0,31.0,32.0,33.0,34.0,35.0,36.0,37.0,38.0,39.0,40.0,41.0,42.0,43.0,44.0,45.0,46.0,47.0,48.0,49.0,50.0,51.0,52.0,53.0,54.0,55.0,56.0,57.0,58.0,59.0,60.0,65.0,70.0,75.0,80.0,85.0,90.0,95.0,100.0,105.0,110.0,115.0,120.0,125.0,130.0,135.0,140.0,145.0,150.0,155.0,160.0,165.0,170.0,175.0,180.0,185.0,190.0,195.0,200.0,205.0,210.0,215.0,220.0,225.0,230.0,235.0,240.0,245.0,250.0,255.0,260.0,265.0,270.0,275.0,280.0,285.0,290.0,295.0,300.0,330.0,360.0,390.0,420.0,450.0,480.0,510.0,540.0,570.0,600.0,630.0,660.0,690.0,720.0,750.0,780.0,810.0,840.0,870.0,900.0,930.0,960.0,990.0,1020.0,1050.0,1080.0,1110.0,1140.0,1170.0,1200.0,1230.0,1260.0,1290.0,1320.0,1350.0,1380.0,1410.0,1440.0,1470.0,1500.0,1530.0,1560.0,1590.0,1620.0,1650.0,1680.0,1710.0,1740.0,1770.0,1800.0,1830.0,1860.0,1890.0,1920.0,1950.0,1980.0,2010.0,2040.0,2070.0,2100.0,2130.0,2160.0,2190.0,2220.0,2250.0,2280.0,2310.0,2340.0,2370.0,2400.0,2430.0,2460.0,2490.0,2520.0,2550.0,2580.0,2610.0,2640.0,2670.0,2700.0,2730.0,2760.0,2790.0,2820.0,2850.0,2880.0,2910.0,2940.0,2970.0,3000.0
Removal of bRaf activation by PKA	2700.0 [s]	OutputTimes 0.0,0.01,0.02,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9,1.0,1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8,1.9,2.0,2.1,2.2,2.3,2.4,2.5,2.6,2.7,2.8,2.9,3.0,3.1,3.2,3.3,3.4,3.5,3.6,3.7,3.8,3.9,4.0,4.1,4.2,4.3,4.4,4.5,4.6,4.7,4.8,4.9,5.0,6.0,7.0,8.0,9.0,10.0,11.0,12.0,13.0,14.0,15.0,16.0,17.0,18.0,19.0,20.0,21.0,22.0,23.0,24.0,25.0,26.0,27.0,28.0,29.0,30.0,31.0,32.0,33.0,34.0,35.0,36.0,37.0,38.0,39.0,40.0,41.0,42.0,43.0,44.0,45.0,46.0,47.0,48.0,49.0,50.0,51.0,52.0,53.0,54.0,55.0,56.0,57.0,58.0,59.0,60.0,65.0,70.0,75.0,80.0,85.0,90.0,95.0,100.0,105.0,110.0,115.0,120.0,125.0,130.0,135.0,140.0,145.0,150.0,155.0,160.0,165.0,170.0,175.0,180.0,185.0,190.0,195.0,200.0,205.0,210.0,215.0,220.0,225.0,230.0,235.0,240.0,245.0,250.0,255.0,260.0,265.0,270.0,275.0,280.0,285.0,290.0,295.0,300.0,330.0,360.0,390.0,420.0,450.0,480.0,510.0,540.0,570.0,600.0,630.0,660.0,690.0,720.0,750.0,780.0,810.0,840.0,870.0,900.0,930.0,960.0,990.0,1020.0,1050.0,1080.0,1110.0,1140.0,1170.0,1200.0,1230.0,1260.0,1290.0,1320.0,1350.0,1380.0,1410.0,1440.0,1470.0,1500.0,1530.0,1560.0,1590.0,1620.0,1650.0,1680.0,1710.0,1740.0,1770.0,1800.0,1830.0,1860.0,1890.0,1920.0,1950.0,1980.0,2010.0,2040.0,2070.0,2100.0,2130.0,2160.0,2190.0,2220.0,2250.0,2280.0,2310.0,2340.0,2370.0,2400.0,2430.0,2460.0,2490.0,2520.0,2550.0,2580.0,2610.0,2640.0,2670.0,2700.0,2730.0,2760.0,2790.0,2820.0,2850.0,2880.0,2910.0,2940.0,2970.0,3000.0
Iso 2	2700.0 [s]	OutputTimes 0.0,0.01,0.02,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9,1.0,1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8,1.9,2.0,2.1,2.2,2.3,2.4,2.5,2.6,2.7,2.8,2.9,3.0,3.1,3.2,3.3,3.4,3.5,3.6,3.7,3.8,3.9,4.0,4.1,4.2,4.3,4.4,4.5,4.6,4.7,4.8,4.9,5.0,6.0,7.0,8.0,9.0,10.0,11.0,12.0,13.0,14.0,15.0,16.0,17.0,18.0,19.0,20.0,21.0,22.0,23.0,24.0,25.0,26.0,27.0,28.0,29.0,30.0,31.0,32.0,33.0,34.0,35.0,36.0,37.0,38.0,39.0,40.0,41.0,42.0,43.0,44.0,45.0,46.0,47.0,48.0,49.0,50.0,51.0,52.0,53.0,54.0,55.0,56.0,57.0,58.0,59.0,60.0,65.0,70.0,75.0,80.0,85.0,90.0,95.0,100.0,105.0,110.0,115.0,120.0,125.0,130.0,135.0,140.0,145.0,150.0,155.0,160.0,165.0,170.0,175.0,180.0,185.0,190.0,195.0,200.0,205.0,210.0,215.0,220.0,225.0,230.0,235.0,240.0,245.0,250.0,255.0,260.0,265.0,270.0,275.0,280.0,285.0,290.0,295.0,300.0,330.0,360.0,390.0,420.0,450.0,480.0,510.0,540.0,570.0,600.0,630.0,660.0,690.0,720.0,750.0,780.0,810.0,840.0,870.0,900.0,930.0,960.0,990.0,1020.0,1050.0,1080.0,1110.0,1140.0,1170.0,1200.0,1230.0,1260.0,1290.0,1320.0,1350.0,1380.0,1410.0,1440.0,1470.0,1500.0,1530.0,1560.0,1590.0,1620.0,1650.0,1680.0,1710.0,1740.0,1770.0,1800.0,1830.0,1860.0,1890.0,1920.0,1950.0,1980.0,2010.0,2040.0,2070.0,2100.0,2130.0,2160.0,2190.0,2220.0,2250.0,2280.0,2310.0,2340.0,2370.0,2400.0,2430.0,2460.0,2490.0,2520.0,2550.0,2580.0,2610.0,2640.0,2670.0,2700.0,2730.0,2760.0,2790.0,2820.0,2850.0,2880.0,2910.0,2940.0,2970.0,3000.0
Removal of PKA	2700.0 [s]	OutputTimes 0.0,0.01,0.02,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9,1.0,1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8,1.9,2.0,2.1,2.2,2.3,2.4,2.5,2.6,2.7,2.8,2.9,3.0,3.1,3.2,3.3,3.4,3.5,3.6,3.7,3.8,3.9,4.0,4.1,4.2,4.3,4.4,4.5,4.6,4.7,4.8,4.9,5.0,6.0,7.0,8.0,9.0,10.0,11.0,12.0,13.0,14.0,15.0,16.0,17.0,18.0,19.0,20.0,21.0,22.0,23.0,24.0,25.0,26.0,27.0,28.0,29.0,30.0,31.0,32.0,33.0,34.0,35.0,36.0,37.0,38.0,39.0,40.0,41.0,42.0,43.0,44.0,45.0,46.0,47.0,48.0,49.0,50.0,51.0,52.0,53.0,54.0,55.0,56.0,57.0,58.0,59.0,60.0,65.0,70.0,75.0,80.0,85.0,90.0,95.0,100.0,105.0,110.0,115.0,120.0,125.0,130.0,135.0,140.0,145.0,150.0,155.0,160.0,165.0,170.0,175.0,180.0,185.0,190.0,195.0,200.0,205.0,210.0,215.0,220.0,225.0,230.0,235.0,240.0,245.0,250.0,255.0,260.0,265.0,270.0,275.0,280.0,285.0,290.0,295.0,300.0,330.0,360.0,390.0,420.0,450.0,480.0,510.0,540.0,570.0,600.0,630.0,660.0,690.0,720.0,750.0,780.0,810.0,840.0,870.0,900.0,930.0,960.0,990.0,1020.0,1050.0,1080.0,1110.0,1140.0,1170.0,1200.0,1230.0,1260.0,1290.0,1320.0,1350.0,1380.0,1410.0,1440.0,1470.0,1500.0,1530.0,1560.0,1590.0,1620.0,1650.0,1680.0,1710.0,1740.0,1770.0,1800.0,1830.0,1860.0,1890.0,1920.0,1950.0,1980.0,2010.0,2040.0,2070.0,2100.0,2130.0,2160.0,2190.0,2220.0,2250.0,2280.0,2310.0,2340.0,2370.0,2400.0,2430.0,2460.0,2490.0,2520.0,2550.0,2580.0,2610.0,2640.0,2670.0,2700.0,2730.0,2760.0,2790.0,2820.0,2850.0,2880.0,2910.0,2940.0,2970.0,3000.0
Removal of PKA deact PTP	2700.0 [s]	OutputTimes 0.0,0.01,0.02,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9,1.0,1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8,1.9,2.0,2.1,2.2,2.3,2.4,2.5,2.6,2.7,2.8,2.9,3.0,3.1,3.2,3.3,3.4,3.5,3.6,3.7,3.8,3.9,4.0,4.1,4.2,4.3,4.4,4.5,4.6,4.7,4.8,4.9,5.0,6.0,7.0,8.0,9.0,10.0,11.0,12.0,13.0,14.0,15.0,16.0,17.0,18.0,19.0,20.0,21.0,22.0,23.0,24.0,25.0,26.0,27.0,28.0,29.0,30.0,31.0,32.0,33.0,34.0,35.0,36.0,37.0,38.0,39.0,40.0,41.0,42.0,43.0,44.0,45.0,46.0,47.0,48.0,49.0,50.0,51.0,52.0,53.0,54.0,55.0,56.0,57.0,58.0,59.0,60.0,65.0,70.0,75.0,80.0,85.0,90.0,95.0,100.0,105.0,110.0,115.0,120.0,125.0,130.0,135.0,140.0,145.0,150.0,155.0,160.0,165.0,170.0,175.0,180.0,185.0,190.0,195.0,200.0,205.0,210.0,215.0,220.0,225.0,230.0,235.0,240.0,245.0,250.0,255.0,260.0,265.0,270.0,275.0,280.0,285.0,290.0,295.0,300.0,330.0,360.0,390.0,420.0,450.0,480.0,510.0,540.0,570.0,600.0,630.0,660.0,690.0,720.0,750.0,780.0,810.0,840.0,870.0,900.0,930.0,960.0,990.0,1020.0,1050.0,1080.0,1110.0,1140.0,1170.0,1200.0,1230.0,1260.0,1290.0,1320.0,1350.0,1380.0,1410.0,1440.0,1470.0,1500.0,1530.0,1560.0,1590.0,1620.0,1650.0,1680.0,1710.0,1740.0,1770.0,1800.0,1830.0,1860.0,1890.0,1920.0,1950.0,1980.0,2010.0,2040.0,2070.0,2100.0,2130.0,2160.0,2190.0,2220.0,2250.0,2280.0,2310.0,2340.0,2370.0,2400.0,2430.0,2460.0,2490.0,2520.0,2550.0,2580.0,2610.0,2640.0,2670.0,2700.0,2730.0,2760.0,2790.0,2820.0,2850.0,2880.0,2910.0,2940.0,2970.0,3000.0
Removal of MSK	2700.0 [s]	OutputTimes 0.0,0.01,0.02,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9,1.0,1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8,1.9,2.0,2.1,2.2,2.3,2.4,2.5,2.6,2.7,2.8,2.9,3.0,3.1,3.2,3.3,3.4,3.5,3.6,3.7,3.8,3.9,4.0,4.1,4.2,4.3,4.4,4.5,4.6,4.7,4.8,4.9,5.0,6.0,7.0,8.0,9.0,10.0,11.0,12.0,13.0,14.0,15.0,16.0,17.0,18.0,19.0,20.0,21.0,22.0,23.0,24.0,25.0,26.0,27.0,28.0,29.0,30.0,31.0,32.0,33.0,34.0,35.0,36.0,37.0,38.0,39.0,40.0,41.0,42.0,43.0,44.0,45.0,46.0,47.0,48.0,49.0,50.0,51.0,52.0,53.0,54.0,55.0,56.0,57.0,58.0,59.0,60.0,65.0,70.0,75.0,80.0,85.0,90.0,95.0,100.0,105.0,110.0,115.0,120.0,125.0,130.0,135.0,140.0,145.0,150.0,155.0,160.0,165.0,170.0,175.0,180.0,185.0,190.0,195.0,200.0,205.0,210.0,215.0,220.0,225.0,230.0,235.0,240.0,245.0,250.0,255.0,260.0,265.0,270.0,275.0,280.0,285.0,290.0,295.0,300.0,330.0,360.0,390.0,420.0,450.0,480.0,510.0,540.0,570.0,600.0,630.0,660.0,690.0,720.0,750.0,780.0,810.0,840.0,870.0,900.0,930.0,960.0,990.0,1020.0,1050.0,1080.0,1110.0,1140.0,1170.0,1200.0,1230.0,1260.0,1290.0,1320.0,1350.0,1380.0,1410.0,1440.0,1470.0,1500.0,1530.0,1560.0,1590.0,1620.0,1650.0,1680.0,1710.0,1740.0,1770.0,1800.0,1830.0,1860.0,1890.0,1920.0,1950.0,1980.0,2010.0,2040.0,2070.0,2100.0,2130.0,2160.0,2190.0,2220.0,2250.0,2280.0,2310.0,2340.0,2370.0,2400.0,2430.0,2460.0,2490.0,2520.0,2550.0,2580.0,2610.0,2640.0,2670.0,2700.0,2730.0,2760.0,2790.0,2820.0,2850.0,2880.0,2910.0,2940.0,2970.0,3000.0
Removal of PKI inhibition	2700.0 [s]	OutputTimes 0.0,0.01,0.02,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9,1.0,1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8,1.9,2.0,2.1,2.2,2.3,2.4,2.5,2.6,2.7,2.8,2.9,3.0,3.1,3.2,3.3,3.4,3.5,3.6,3.7,3.8,3.9,4.0,4.1,4.2,4.3,4.4,4.5,4.6,4.7,4.8,4.9,5.0,6.0,7.0,8.0,9.0,10.0,11.0,12.0,13.0,14.0,15.0,16.0,17.0,18.0,19.0,20.0,21.0,22.0,23.0,24.0,25.0,26.0,27.0,28.0,29.0,30.0,31.0,32.0,33.0,34.0,35.0,36.0,37.0,38.0,39.0,40.0,41.0,42.0,43.0,44.0,45.0,46.0,47.0,48.0,49.0,50.0,51.0,52.0,53.0,54.0,55.0,56.0,57.0,58.0,59.0,60.0,65.0,70.0,75.0,80.0,85.0,90.0,95.0,100.0,105.0,110.0,115.0,120.0,125.0,130.0,135.0,140.0,145.0,150.0,155.0,160.0,165.0,170.0,175.0,180.0,185.0,190.0,195.0,200.0,205.0,210.0,215.0,220.0,225.0,230.0,235.0,240.0,245.0,250.0,255.0,260.0,265.0,270.0,275.0,280.0,285.0,290.0,295.0,300.0,330.0,360.0,390.0,420.0,450.0,480.0,510.0,540.0,570.0,600.0,630.0,660.0,690.0,720.0,750.0,780.0,810.0,840.0,870.0,900.0,930.0,960.0,990.0,1020.0,1050.0,1080.0,1110.0,1140.0,1170.0,1200.0,1230.0,1260.0,1290.0,1320.0,1350.0,1380.0,1410.0,1440.0,1470.0,1500.0,1530.0,1560.0,1590.0,1620.0,1650.0,1680.0,1710.0,1740.0,1770.0,1800.0,1830.0,1860.0,1890.0,1920.0,1950.0,1980.0,2010.0,2040.0,2070.0,2100.0,2130.0,2160.0,2190.0,2220.0,2250.0,2280.0,2310.0,2340.0,2370.0,2400.0,2430.0,2460.0,2490.0,2520.0,2550.0,2580.0,2610.0,2640.0,2670.0,2700.0,2730.0,2760.0,2790.0,2820.0,2850.0,2880.0,2910.0,2940.0,2970.0,3000.0
Removal of PKA act CREB	2700.0 [s]	OutputTimes 0.0,0.01,0.02,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9,1.0,1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8,1.9,2.0,2.1,2.2,2.3,2.4,2.5,2.6,2.7,2.8,2.9,3.0,3.1,3.2,3.3,3.4,3.5,3.6,3.7,3.8,3.9,4.0,4.1,4.2,4.3,4.4,4.5,4.6,4.7,4.8,4.9,5.0,6.0,7.0,8.0,9.0,10.0,11.0,12.0,13.0,14.0,15.0,16.0,17.0,18.0,19.0,20.0,21.0,22.0,23.0,24.0,25.0,26.0,27.0,28.0,29.0,30.0,31.0,32.0,33.0,34.0,35.0,36.0,37.0,38.0,39.0,40.0,41.0,42.0,43.0,44.0,45.0,46.0,47.0,48.0,49.0,50.0,51.0,52.0,53.0,54.0,55.0,56.0,57.0,58.0,59.0,60.0,65.0,70.0,75.0,80.0,85.0,90.0,95.0,100.0,105.0,110.0,115.0,120.0,125.0,130.0,135.0,140.0,145.0,150.0,155.0,160.0,165.0,170.0,175.0,180.0,185.0,190.0,195.0,200.0,205.0,210.0,215.0,220.0,225.0,230.0,235.0,240.0,245.0,250.0,255.0,260.0,265.0,270.0,275.0,280.0,285.0,290.0,295.0,300.0,330.0,360.0,390.0,420.0,450.0,480.0,510.0,540.0,570.0,600.0,630.0,660.0,690.0,720.0,750.0,780.0,810.0,840.0,870.0,900.0,930.0,960.0,990.0,1020.0,1050.0,1080.0,1110.0,1140.0,1170.0,1200.0,1230.0,1260.0,1290.0,1320.0,1350.0,1380.0,1410.0,1440.0,1470.0,1500.0,1530.0,1560.0,1590.0,1620.0,1650.0,1680.0,1710.0,1740.0,1770.0,1800.0,1830.0,1860.0,1890.0,1920.0,1950.0,1980.0,2010.0,2040.0,2070.0,2100.0,2130.0,2160.0,2190.0,2220.0,2250.0,2280.0,2310.0,2340.0,2370.0,2400.0,2430.0,2460.0,2490.0,2520.0,2550.0,2580.0,2610.0,2640.0,2670.0,2700.0,2730.0,2760.0,2790.0,2820.0,2850.0,2880.0,2910.0,2940.0,2970.0,3000.0
Removal of bRaf->MEK	2700.0 [s]	OutputTimes 0.0,0.01,0.02,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9,1.0,1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8,1.9,2.0,2.1,2.2,2.3,2.4,2.5,2.6,2.7,2.8,2.9,3.0,3.1,3.2,3.3,3.4,3.5,3.6,3.7,3.8,3.9,4.0,4.1,4.2,4.3,4.4,4.5,4.6,4.7,4.8,4.9,5.0,6.0,7.0,8.0,9.0,10.0,11.0,12.0,13.0,14.0,15.0,16.0,17.0,18.0,19.0,20.0,21.0,22.0,23.0,24.0,25.0,26.0,27.0,28.0,29.0,30.0,31.0,32.0,33.0,34.0,35.0,36.0,37.0,38.0,39.0,40.0,41.0,42.0,43.0,44.0,45.0,46.0,47.0,48.0,49.0,50.0,51.0,52.0,53.0,54.0,55.0,56.0,57.0,58.0,59.0,60.0,65.0,70.0,75.0,80.0,85.0,90.0,95.0,100.0,105.0,110.0,115.0,120.0,125.0,130.0,135.0,140.0,145.0,150.0,155.0,160.0,165.0,170.0,175.0,180.0,185.0,190.0,195.0,200.0,205.0,210.0,215.0,220.0,225.0,230.0,235.0,240.0,245.0,250.0,255.0,260.0,265.0,270.0,275.0,280.0,285.0,290.0,295.0,300.0,330.0,360.0,390.0,420.0,450.0,480.0,510.0,540.0,570.0,600.0,630.0,660.0,690.0,720.0,750.0,780.0,810.0,840.0,870.0,900.0,930.0,960.0,990.0,1020.0,1050.0,1080.0,1110.0,1140.0,1170.0,1200.0,1230.0,1260.0,1290.0,1320.0,1350.0,1380.0,1410.0,1440.0,1470.0,1500.0,1530.0,1560.0,1590.0,1620.0,1650.0,1680.0,1710.0,1740.0,1770.0,1800.0,1830.0,1860.0,1890.0,1920.0,1950.0,1980.0,2010.0,2040.0,2070.0,2100.0,2130.0,2160.0,2190.0,2220.0,2250.0,2280.0,2310.0,2340.0,2370.0,2400.0,2430.0,2460.0,2490.0,2520.0,2550.0,2580.0,2610.0,2640.0,2670.0,2700.0,2730.0,2760.0,2790.0,2820.0,2850.0,2880.0,2910.0,2940.0,2970.0,3000.0
Removal MEK->MAPK	2700.0 [s]	OutputTimes 0.0,0.01,0.02,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9,1.0,1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8,1.9,2.0,2.1,2.2,2.3,2.4,2.5,2.6,2.7,2.8,2.9,3.0,3.1,3.2,3.3,3.4,3.5,3.6,3.7,3.8,3.9,4.0,4.1,4.2,4.3,4.4,4.5,4.6,4.7,4.8,4.9,5.0,6.0,7.0,8.0,9.0,10.0,11.0,12.0,13.0,14.0,15.0,16.0,17.0,18.0,19.0,20.0,21.0,22.0,23.0,24.0,25.0,26.0,27.0,28.0,29.0,30.0,31.0,32.0,33.0,34.0,35.0,36.0,37.0,38.0,39.0,40.0,41.0,42.0,43.0,44.0,45.0,46.0,47.0,48.0,49.0,50.0,51.0,52.0,53.0,54.0,55.0,56.0,57.0,58.0,59.0,60.0,65.0,70.0,75.0,80.0,85.0,90.0,95.0,100.0,105.0,110.0,115.0,120.0,125.0,130.0,135.0,140.0,145.0,150.0,155.0,160.0,165.0,170.0,175.0,180.0,185.0,190.0,195.0,200.0,205.0,210.0,215.0,220.0,225.0,230.0,235.0,240.0,245.0,250.0,255.0,260.0,265.0,270.0,275.0,280.0,285.0,290.0,295.0,300.0,330.0,360.0,390.0,420.0,450.0,480.0,510.0,540.0,570.0,600.0,630.0,660.0,690.0,720.0,750.0,780.0,810.0,840.0,870.0,900.0,930.0,960.0,990.0,1020.0,1050.0,1080.0,1110.0,1140.0,1170.0,1200.0,1230.0,1260.0,1290.0,1320.0,1350.0,1380.0,1410.0,1440.0,1470.0,1500.0,1530.0,1560.0,1590.0,1620.0,1650.0,1680.0,1710.0,1740.0,1770.0,1800.0,1830.0,1860.0,1890.0,1920.0,1950.0,1980.0,2010.0,2040.0,2070.0,2100.0,2130.0,2160.0,2190.0,2220.0,2250.0,2280.0,2310.0,2340.0,2370.0,2400.0,2430.0,2460.0,2490.0,2520.0,2550.0,2580.0,2610.0,2640.0,2670.0,2700.0,2730.0,2760.0,2790.0,2820.0,2850.0,2880.0,2910.0,2940.0,2970.0,3000.0
Removal of PTP-\|MAPK	2700.0 [s]	OutputTimes 0.0,0.01,0.02,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9,1.0,1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8,1.9,2.0,2.1,2.2,2.3,2.4,2.5,2.6,2.7,2.8,2.9,3.0,3.1,3.2,3.3,3.4,3.5,3.6,3.7,3.8,3.9,4.0,4.1,4.2,4.3,4.4,4.5,4.6,4.7,4.8,4.9,5.0,6.0,7.0,8.0,9.0,10.0,11.0,12.0,13.0,14.0,15.0,16.0,17.0,18.0,19.0,20.0,21.0,22.0,23.0,24.0,25.0,26.0,27.0,28.0,29.0,30.0,31.0,32.0,33.0,34.0,35.0,36.0,37.0,38.0,39.0,40.0,41.0,42.0,43.0,44.0,45.0,46.0,47.0,48.0,49.0,50.0,51.0,52.0,53.0,54.0,55.0,56.0,57.0,58.0,59.0,60.0,65.0,70.0,75.0,80.0,85.0,90.0,95.0,100.0,105.0,110.0,115.0,120.0,125.0,130.0,135.0,140.0,145.0,150.0,155.0,160.0,165.0,170.0,175.0,180.0,185.0,190.0,195.0,200.0,205.0,210.0,215.0,220.0,225.0,230.0,235.0,240.0,245.0,250.0,255.0,260.0,265.0,270.0,275.0,280.0,285.0,290.0,295.0,300.0,330.0,360.0,390.0,420.0,450.0,480.0,510.0,540.0,570.0,600.0,630.0,660.0,690.0,720.0,750.0,780.0,810.0,840.0,870.0,900.0,930.0,960.0,990.0,1020.0,1050.0,1080.0,1110.0,1140.0,1170.0,1200.0,1230.0,1260.0,1290.0,1320.0,1350.0,1380.0,1410.0,1440.0,1470.0,1500.0,1530.0,1560.0,1590.0,1620.0,1650.0,1680.0,1710.0,1740.0,1770.0,1800.0,1830.0,1860.0,1890.0,1920.0,1950.0,1980.0,2010.0,2040.0,2070.0,2100.0,2130.0,2160.0,2190.0,2220.0,2250.0,2280.0,2310.0,2340.0,2370.0,2400.0,2430.0,2460.0,2490.0,2520.0,2550.0,2580.0,2610.0,2640.0,2670.0,2700.0,2730.0,2760.0,2790.0,2820.0,2850.0,2880.0,2910.0,2940.0,2970.0,3000.0
Removal of PKA import	2700.0 [s]	OutputTimes 0.0,0.01,0.02,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9,1.0,1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8,1.9,2.0,2.1,2.2,2.3,2.4,2.5,2.6,2.7,2.8,2.9,3.0,3.1,3.2,3.3,3.4,3.5,3.6,3.7,3.8,3.9,4.0,4.1,4.2,4.3,4.4,4.5,4.6,4.7,4.8,4.9,5.0,6.0,7.0,8.0,9.0,10.0,11.0,12.0,13.0,14.0,15.0,16.0,17.0,18.0,19.0,20.0,21.0,22.0,23.0,24.0,25.0,26.0,27.0,28.0,29.0,30.0,31.0,32.0,33.0,34.0,35.0,36.0,37.0,38.0,39.0,40.0,41.0,42.0,43.0,44.0,45.0,46.0,47.0,48.0,49.0,50.0,51.0,52.0,53.0,54.0,55.0,56.0,57.0,58.0,59.0,60.0,65.0,70.0,75.0,80.0,85.0,90.0,95.0,100.0,105.0,110.0,115.0,120.0,125.0,130.0,135.0,140.0,145.0,150.0,155.0,160.0,165.0,170.0,175.0,180.0,185.0,190.0,195.0,200.0,205.0,210.0,215.0,220.0,225.0,230.0,235.0,240.0,245.0,250.0,255.0,260.0,265.0,270.0,275.0,280.0,285.0,290.0,295.0,300.0,330.0,360.0,390.0,420.0,450.0,480.0,510.0,540.0,570.0,600.0,630.0,660.0,690.0,720.0,750.0,780.0,810.0,840.0,870.0,900.0,930.0,960.0,990.0,1020.0,1050.0,1080.0,1110.0,1140.0,1170.0,1200.0,1230.0,1260.0,1290.0,1320.0,1350.0,1380.0,1410.0,1440.0,1470.0,1500.0,1530.0,1560.0,1590.0,1620.0,1650.0,1680.0,1710.0,1740.0,1770.0,1800.0,1830.0,1860.0,1890.0,1920.0,1950.0,1980.0,2010.0,2040.0,2070.0,2100.0,2130.0,2160.0,2190.0,2220.0,2250.0,2280.0,2310.0,2340.0,2370.0,2400.0,2430.0,2460.0,2490.0,2520.0,2550.0,2580.0,2610.0,2640.0,2670.0,2700.0,2730.0,2760.0,2790.0,2820.0,2850.0,2880.0,2910.0,2940.0,2970.0,3000.0
Removal of MAPK import	2700.0 [s]	OutputTimes 0.0,0.01,0.02,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9,1.0,1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8,1.9,2.0,2.1,2.2,2.3,2.4,2.5,2.6,2.7,2.8,2.9,3.0,3.1,3.2,3.3,3.4,3.5,3.6,3.7,3.8,3.9,4.0,4.1,4.2,4.3,4.4,4.5,4.6,4.7,4.8,4.9,5.0,6.0,7.0,8.0,9.0,10.0,11.0,12.0,13.0,14.0,15.0,16.0,17.0,18.0,19.0,20.0,21.0,22.0,23.0,24.0,25.0,26.0,27.0,28.0,29.0,30.0,31.0,32.0,33.0,34.0,35.0,36.0,37.0,38.0,39.0,40.0,41.0,42.0,43.0,44.0,45.0,46.0,47.0,48.0,49.0,50.0,51.0,52.0,53.0,54.0,55.0,56.0,57.0,58.0,59.0,60.0,65.0,70.0,75.0,80.0,85.0,90.0,95.0,100.0,105.0,110.0,115.0,120.0,125.0,130.0,135.0,140.0,145.0,150.0,155.0,160.0,165.0,170.0,175.0,180.0,185.0,190.0,195.0,200.0,205.0,210.0,215.0,220.0,225.0,230.0,235.0,240.0,245.0,250.0,255.0,260.0,265.0,270.0,275.0,280.0,285.0,290.0,295.0,300.0,330.0,360.0,390.0,420.0,450.0,480.0,510.0,540.0,570.0,600.0,630.0,660.0,690.0,720.0,750.0,780.0,810.0,840.0,870.0,900.0,930.0,960.0,990.0,1020.0,1050.0,1080.0,1110.0,1140.0,1170.0,1200.0,1230.0,1260.0,1290.0,1320.0,1350.0,1380.0,1410.0,1440.0,1470.0,1500.0,1530.0,1560.0,1590.0,1620.0,1650.0,1680.0,1710.0,1740.0,1770.0,1800.0,1830.0,1860.0,1890.0,1920.0,1950.0,1980.0,2010.0,2040.0,2070.0,2100.0,2130.0,2160.0,2190.0,2220.0,2250.0,2280.0,2310.0,2340.0,2370.0,2400.0,2430.0,2460.0,2490.0,2520.0,2550.0,2580.0,2610.0,2640.0,2670.0,2700.0,2730.0,2760.0,2790.0,2820.0,2850.0,2880.0,2910.0,2940.0,2970.0,3000.0

Geometry non-spatial1212631236 See in Dashboard
(Origin: 0.0, 0.0, 0.0; Extent: 10.0, 10.0, 10.0[um])
Dimension	Type	Subdomain	Adjacent Subvolumes	Size	Mapped Compartment
	Compartmental	Compartment			nuclear membrane

Global Parameters

Global Parameters See in Dashboard
Name	Expression
kimportPKI	0.001[um.s-1]

Km_Rap1BRaf	0.5[uM]

kcat_Rap1Braf	0.105[s-1]