Physiology
Reaction Diagram
Cross-References
Annotations
Reactions
| Reactions | Name | Structure | Kinetics | Depiction |
|---|---|---|---|---|
| BRaf_star_cellBRaf_cell | PP_deact_BRaf | cell | HMMIrreversible | |
| BRaf_cellBRaf_star_cell | PKA_act_BRaf | cell | GeneralKinetics | |
| GRK_PMGRK_cell | GRK to cytosol | PM | MassAction | |
| Rap1_Epac_GMEpac_cAMP_cell+Rap1_GTP_GM | 08: Epac exchange | GM | GeneralKinetics | |
| cAMP4_R2C2_cellcAMP4_R2C_cell+PKA_cell | Release of C1 | cell | MassAction | |
| MAPKK_cellMAPKK_Ser_cell | Rap1raf_act_MAPKK | GM | GeneralKinetics | |
| MKP1_cellMKP1p_cell | MKP1 phospho by MAPKactive | cell | HMMIrreversible | |
| MKP1p_nucleus | MKP1p turnover nucleus | nucleus | MassAction | |
| cAMP_cellAMP_cell | 07: PDE | cell | HMMIrreversible | |
| MAPK_active_nucleusMAPK_thr_nucleus | MKP1p deact MAPKact | nucleus | HMMIrreversible | |
| MKP1_nucleus | MKP1 turnover in nucleus | nucleus | MassAction | |
| isoprenaline_ec+beta_PMbeta_isop_PM | 01b: isoprenaline binding | PM | MassAction | |
| PTPSL_star_cellPTPSL_cell | PTPSL_dephos | cell | HMMIrreversible | |
| MAPK_Thr_cellMAPK_active_cell | MAPKK_act_MAPK_thr | cell | HMMIrreversible | |
| beta_P_PMbeta_PM | Receptor recycling | PM | MassAction | |
| PDE_cellPDE_star_cell | PKA_act_PDE | cell | HMMIrreversible | |
| MAPKK_active_cellMAPKK_Ser_cell | PP2A_inact_MAPKK_active | cell | HMMIrreversible | |
| inhibitedPKA_cellPKI_cell+PKA_cell | PKA release by PKI | cell | MassAction | |
| cAMP3_R2C2_cell+cAMP_cellcAMP4_R2C2_cell | cAMP_binds_A2 | cell | MassAction | |
| MAPKK_cellMAPKK_Ser_cell | BRaf_act_MAPKK | cell | HMMIrreversible | |
| Rap1_GDP_GM+Epac_cAMP_cellRap1_Epac_GM | 8a: Rap1-Epac binding | GM | MassAction | |
| cAMP_cell+Epac_cellEpac_cAMP_cell | Epac-cAMP binding | cell | MassAction | |
| G_bg_PM+GRK_cellGRK_Gbg_PM | GRK-Gbg binding | PM | MassAction | |
| MAPK_Thr_cellMAPK_cell | MKPp_decat_MAPKtyr | cell | HMMIrreversible | |
| MAPK_thr_nucleusMAPK_nucleus | MKP1p deact MAPKtyr | nucleus | HMMIrreversible | |
| Gsa_GDP_PM+G_bg_PMGs_trimer_PM | 14b: Gs trimerization | PM | MassAction | |
| PTPSL_cellPTPSL_star_cell | PKA_deact_PTPSL | cell | HMMIrreversible | |
| CREB_nucleusCREB_Ser_nucleus | MSK_act_CREB | nucleus | HMMIrreversible | |
| cAMP_cellAMP_cell | PDE_highKm deact cAMP | cell | HMMIrreversible | |
| MSK_active_nucleusMSK_nucleus | MSK_dephos | nucleus | MassAction | |
| Rap1_GDP_GMRap1_GTP_GM | constit exch+hydrolysis | GM | MassAction | |
| CREB_nucleusCREB_Ser_nucleus | PKA_act_CREB | nucleus | HMMIrreversible | |
| MAPK_active_cellMAPK_Thr_cell | MAPK dephosph by PTP | cell | HMMIrreversible | |
| CREB_Ser_nucleusCREB_nucleus | PP1A_dephos_CREB | nucleus | HMMIrreversible | |
| MAPK_active_nucleusMAPK_thr_nucleus | MKP1 deact MAPKact | nucleus | HMMIrreversible | |
| MAPK_thr_nucleusMAPK_nucleus | MKP1 deact MAPKtyr | nucleus | HMMIrreversible | |
| MSK_nucleusMSK_active_nucleus | reaction2 | nucleus | HMMIrreversible | |
| MAPK_active_nucleusMAPK_thr_nucleus | MKP2 deact MAPKact | nucleus | HMMIrreversible | |
| cAMP_cell+cAMP2_R2C2_cellcAMP3_R2C2_cell | cAMP_bind_cAMP2R2C2 | cell | MassAction | |
| MAPK_thr_nucleusMAPK_nucleus | MKP2 deact MAPK tyr | nucleus | HMMIrreversible | |
| MKP1_nucleusMKP1p_nucleus | MKP1 phosph by MAPKactive_nucleus | nucleus | HMMIrreversible | |
| MKP1p_nucleusMKP1_nucleus | MKP1 dephosph in nucleus | nucleus | MassAction | |
| MAPK_active_cellMAPK_Thr_cell | MKP1_deact_MAPKactive | cell | HMMIrreversible | |
| Gs_a_PM+AC_PMAC_Gsa_PM | 04: Gs-AC binding | PM | GeneralKinetics | |
| ATP_cellcAMP_cell | 05b: cAMP production | PM | HMMIrreversible | |
| PKI_nucleus+PKA_nucleusinhibitedPKA_nucleus | PKA inhibition by PKI | nucleus | MassAction | |
| R2C2_cell+cAMP_cellcAMP_R2C2_cell | cAMP bind R2C2 | cell | MassAction | |
| CREB_Ser_nucleusCREB_nucleus | Pp2A_deact_CREB | nucleus | HMMIrreversible | |
| beta_isop_PM+Gs_trimer_PMbetaAR_Gs_PM | 2: ARbeta-Gs binding | PM | MassAction | |
| MKP1gene_nucleusMKP1_RNA_nucleus | MAPK_act_MKPtranscription | nucleus | HMMIrreversible | |
| cAMP_cellAMP_cell | PDEstar_deact_cAMP | cell | HMMIrreversible | |
| beta_isop_PMbeta_P_PM | 03: GRK activity | PM | GeneralKinetics | |
| cAMP4_R2C_cellcAMP4_R2_cell+PKA_cell | Release of C2 | cell | MassAction | |
| MKP1gene_nucleusMKP1_RNA_nucleus | MKP1 basal transcription | nucleus | MassAction | |
| Rap1GAP_cell+Rap1_GTP_GMRap1_RGII_GM | 10a: Rap1-RGII binding | GM | MassAction | |
| MKP1_cell | MKP1 turnover | cell | MassAction | |
| cAMP_R2C2_cell+cAMP_cellcAMP2_R2C2_cell | cAMP_binds_cAMPR2C2 | cell | MassAction | |
| Gs_a_PMGsa_GDP_PM | Gs GTPase | PM | GeneralKinetics | |
| Rap1_RGII_GMRap1_GDP_GM+Rap1GAP_cell | 10: Rap1 GTPase | GM | GeneralKinetics | |
| MAPKK_Ser_cellMAPKK_cell | PP2A_inact_MAPKKSer | cell | HMMIrreversible | |
| MAPK_cellMAPK_Thr_cell | MAPKK_act_MAPK | cell | HMMIrreversible | |
| MKP1_RNA_cellMKP1_cell | MKP_translation | cell | MassAction | |
| MAPKK_Ser_cellMAPKK_active_cell | reaction1 | cell | GeneralKinetics | |
| PDE_star_cellPDE_cell | PP2A_dephos_PDEstar | cell | HMMIrreversible | |
| GRK_Gbg_PMGRK_PM+G_bg_PM | GRK PM recruitment | PM | MassAction | |
| MAPK_Thr_cellMAPK_cell | reaction0 | cell | HMMIrreversible | |
| MAPK_active_cellMAPK_Thr_cell | reaction3 | cell | HMMIrreversible | |
| MAPK_Thr_cellMAPK_cell | MKP_decat_MAPKtyr | cell | HMMIrreversible | |
| MAPKK_Ser_cellMAPKK_active_cell | RapRaf_act_MAPKKSer | GM | HMMIrreversible | |
| MKP1p_cell | MKP1p turnover | cell | MassAction | |
| MKP1p_cellMKP1_cell | MKP1 dephosph | cell | MassAction | |
| MAPK_active_cellMAPK_Thr_cell | MKP1p_deact_MAPKactive | cell | HMMIrreversible | |
| betaAR_Gs_PMbeta_isop_PM+Gs_a_PM+G_bg_PM | 02b: Gs activation | PM | MassAction | |
| BRaf_cell+Rap1_GTP_GMRap1_BRaf_GM | Rap1_binds_BRaf | GM | MassAction |
PP_deact_BRaf Universal ID's
PP_deact_BRaf Text Annotations
PKA_act_BRaf Universal ID's
PKA_act_BRaf Text Annotations
GRK to cytosol Universal ID's
GRK to cytosol Text Annotations
08: Epac exchange Universal ID's
08: Epac exchange Text Annotations
Release of C1 Universal ID's
Release of C1 Text Annotations
Rap1raf_act_MAPKK Universal ID's
Rap1raf_act_MAPKK Text Annotations
MKP1 phospho by MAPKactive Universal ID's
MKP1 phospho by MAPKactive Text Annotations
MKP1p turnover nucleus Universal ID's
MKP1p turnover nucleus Text Annotations
07: PDE Universal ID's
07: PDE Text Annotations
MKP1p deact MAPKact Universal ID's
MKP1p deact MAPKact Text Annotations
MKP1 turnover in nucleus Universal ID's
MKP1 turnover in nucleus Text Annotations
01b: isoprenaline binding Universal ID's
01b: isoprenaline binding Text Annotations
PTPSL_dephos Universal ID's
PTPSL_dephos Text Annotations
MAPKK_act_MAPK_thr Universal ID's
MAPKK_act_MAPK_thr Text Annotations
Receptor recycling Universal ID's
Receptor recycling Text Annotations
PKA_act_PDE Universal ID's
PKA_act_PDE Text Annotations
PP2A_inact_MAPKK_active Universal ID's
PP2A_inact_MAPKK_active Text Annotations
PKA release by PKI Universal ID's
PKA release by PKI Text Annotations
cAMP_binds_A2 Universal ID's
cAMP_binds_A2 Text Annotations
BRaf_act_MAPKK Universal ID's
BRaf_act_MAPKK Text Annotations
8a: Rap1-Epac binding Universal ID's
8a: Rap1-Epac binding Text Annotations
Epac-cAMP binding Universal ID's
Epac-cAMP binding Text Annotations
GRK-Gbg binding Universal ID's
GRK-Gbg binding Text Annotations
MKPp_decat_MAPKtyr Universal ID's
MKPp_decat_MAPKtyr Text Annotations
MKP1p deact MAPKtyr Universal ID's
MKP1p deact MAPKtyr Text Annotations
14b: Gs trimerization Universal ID's
14b: Gs trimerization Text Annotations
PKA_deact_PTPSL Universal ID's
PKA_deact_PTPSL Text Annotations
MSK_act_CREB Universal ID's
MSK_act_CREB Text Annotations
PDE_highKm deact cAMP Universal ID's
PDE_highKm deact cAMP Text Annotations
MSK_dephos Universal ID's
MSK_dephos Text Annotations
constit exch+hydrolysis Universal ID's
constit exch+hydrolysis Text Annotations
PKA_act_CREB Universal ID's
PKA_act_CREB Text Annotations
MAPK dephosph by PTP Universal ID's
MAPK dephosph by PTP Text Annotations
PP1A_dephos_CREB Universal ID's
PP1A_dephos_CREB Text Annotations
MKP1 deact MAPKact Universal ID's
MKP1 deact MAPKact Text Annotations
MKP1 deact MAPKtyr Universal ID's
MKP1 deact MAPKtyr Text Annotations
reaction2 Universal ID's
reaction2 Text Annotations
MKP2 deact MAPKact Universal ID's
MKP2 deact MAPKact Text Annotations
cAMP_bind_cAMP2R2C2 Universal ID's
cAMP_bind_cAMP2R2C2 Text Annotations
MKP2 deact MAPK tyr Universal ID's
MKP2 deact MAPK tyr Text Annotations
MKP1 phosph by MAPKactive_nucleus Universal ID's
MKP1 phosph by MAPKactive_nucleus Text Annotations
MKP1 dephosph in nucleus Universal ID's
MKP1 dephosph in nucleus Text Annotations
MKP1_deact_MAPKactive Universal ID's
MKP1_deact_MAPKactive Text Annotations
04: Gs-AC binding Universal ID's
04: Gs-AC binding Text Annotations
05b: cAMP production Universal ID's
05b: cAMP production Text Annotations
PKA inhibition by PKI Universal ID's
PKA inhibition by PKI Text Annotations
cAMP bind R2C2 Universal ID's
cAMP bind R2C2 Text Annotations
Pp2A_deact_CREB Universal ID's
Pp2A_deact_CREB Text Annotations
2: ARbeta-Gs binding Universal ID's
2: ARbeta-Gs binding Text Annotations
MAPK_act_MKPtranscription Universal ID's
MAPK_act_MKPtranscription Text Annotations
PDEstar_deact_cAMP Universal ID's
PDEstar_deact_cAMP Text Annotations
03: GRK activity Universal ID's
03: GRK activity Text Annotations
Release of C2 Universal ID's
Release of C2 Text Annotations
MKP1 basal transcription Universal ID's
MKP1 basal transcription Text Annotations
10a: Rap1-RGII binding Universal ID's
10a: Rap1-RGII binding Text Annotations
MKP1 turnover Universal ID's
MKP1 turnover Text Annotations
cAMP_binds_cAMPR2C2 Universal ID's
cAMP_binds_cAMPR2C2 Text Annotations
Gs GTPase Universal ID's
Gs GTPase Text Annotations
10: Rap1 GTPase Universal ID's
10: Rap1 GTPase Text Annotations
PP2A_inact_MAPKKSer Universal ID's
PP2A_inact_MAPKKSer Text Annotations
MAPKK_act_MAPK Universal ID's
MAPKK_act_MAPK Text Annotations
MKP_translation Universal ID's
MKP_translation Text Annotations
reaction1 Universal ID's
reaction1 Text Annotations
PP2A_dephos_PDEstar Universal ID's
PP2A_dephos_PDEstar Text Annotations
GRK PM recruitment Universal ID's
GRK PM recruitment Text Annotations
reaction0 Universal ID's
reaction0 Text Annotations
reaction3 Universal ID's
reaction3 Text Annotations
MKP_decat_MAPKtyr Universal ID's
MKP_decat_MAPKtyr Text Annotations
RapRaf_act_MAPKKSer Universal ID's
RapRaf_act_MAPKKSer Text Annotations
MKP1p turnover Universal ID's
MKP1p turnover Text Annotations
MKP1 dephosph Universal ID's
MKP1 dephosph Text Annotations
MKP1p_deact_MAPKactive Universal ID's
MKP1p_deact_MAPKactive Text Annotations
02b: Gs activation Universal ID's
02b: Gs activation Text Annotations
Rap1_binds_BRaf Universal ID's
Rap1_binds_BRaf Text Annotations
Expressions for PP_deact_BRaf
reaction rate
J
((Vmax * BRaf_star_cell) / (Km + BRaf_star_cell)) [uM.s-1]
Km (1/2 max)
Km
15.66 [uM]
max reaction rate
Vmax
(kcat * PP2A_cell) [uM.s-1]
local
kcat
6.0 [s-1]
Expressions for PKA_act_BRaf
reaction rate
J
(Vmax * BRaf_cell / (Km + BRaf_cell)) [uM.s-1]
local
Km
1.0 [uM]
local
Vmax
(kcat * PKA_cell) [uM.s-1]
local
kcat
0.1 [s-1]
Expressions for GRK to cytosol
reaction rate
J
((Kf * GRK_PM) - (Kr * GRK_cell)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
forward rate constant
Kf
0.01 [s-1]
reverse rate constant
Kr
0.0 [molecules.um-2.s-1.uM-1]
Expressions for 08: Epac exchange
reaction rate
J_08__Epac_exchange
(Rap1_Epac_GM * kEpacEXCH) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
local
kEpacEXCH
0.2 [s-1]
Expressions for Release of C1
reaction rate
J
((Kf * cAMP4_R2C2_cell) - ((Kr * cAMP4_R2C_cell) * PKA_cell)) [uM.s-1]
forward rate constant
Kf
0.6 [s-1]
reverse rate constant
Kr
0.18 [s-1.uM-1]
Expressions for Rap1raf_act_MAPKK
reaction rate
J
(Vmax * MAPKK_cell / (Km + MAPKK_cell)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
local
Km
0.4 [uM]
local
Vmax
(kcat * Rap1_BRaf_GM) [molecules.um-2.s-1]
local
kcat
0.95 [s-1]
Expressions for MKP1 phospho by MAPKactive
reaction rate
J
((Vmax * MKP1_cell) / (Km + MKP1_cell)) [uM.s-1]
Km (1/2 max)
Km
25.641 [uM]
max reaction rate
Vmax
(kcat * MAPK_active_cell) [uM.s-1]
local
kcat
1.0 [s-1]
Expressions for MKP1p turnover nucleus
reaction rate
J
(Kf * MKP1p_nucleus) [uM.s-1]
forward rate constant
Kf
1.0E-4 [s-1]
reverse rate constant
Kr
0.0 [uM.s-1]
Expressions for 07: PDE
reaction rate
J
((Vmax_07__PDE * cAMP_cell) / (Km_07__PDE + cAMP_cell)) [uM.s-1]
Km (1/2 max)
Km_07__PDE
1.3 [uM]
max reaction rate
Vmax_07__PDE
(kCATpde * PDE_cell) [uM.s-1]
local
kCATpde
8.0 [s-1]
Expressions for MKP1p deact MAPKact
reaction rate
J
((Vmax * MAPK_active_nucleus) / (Km + MAPK_active_nucleus)) [uM.s-1]
Km (1/2 max)
Km
0.0667 [uM]
max reaction rate
Vmax
(kcat * MKP1p_nucleus) [uM.s-1]
local
kcat
1.0 [s-1]
Expressions for MKP1 turnover in nucleus
reaction rate
J
(Kf * MKP1_nucleus) [uM.s-1]
forward rate constant
Kf
3.7E-4 [s-1]
reverse rate constant
Kr
0.0 [uM.s-1]
Expressions for 01b: isoprenaline binding
reaction rate
J
(((Kf_01b__isoprenaline_binding * isoprenaline_ec) * beta_PM) - (Kr_01b__isoprenaline_binding * beta_isop_PM)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
forward rate constant
Kf_01b__isoprenaline_binding
0.1 [s-1.uM-1]
reverse rate constant
Kr_01b__isoprenaline_binding
0.1 [s-1]
Expressions for PTPSL_dephos
reaction rate
J
((Vmax * PTPSL_star_cell) / (Km + PTPSL_star_cell)) [uM.s-1]
Km (1/2 max)
Km
6.0 [uM]
max reaction rate
Vmax
(kcat * PP1_cell) [uM.s-1]
local
kcat
5.0 [s-1]
Expressions for MAPKK_act_MAPK_thr
reaction rate
J
((Vmax * MAPK_Thr_cell) / (Km + MAPK_Thr_cell)) [uM.s-1]
Km (1/2 max)
Km
0.046296 [uM]
max reaction rate
Vmax
(0.15 * MAPKK_active_cell) [uM.s-1]
Expressions for Receptor recycling
reaction rate
J
((Kf * beta_P_PM) - (Kr * beta_PM)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
forward rate constant
Kf
4.7E-4 [s-1]
reverse rate constant
Kr
0.0 [s-1]
Expressions for PKA_act_PDE
reaction rate
J
((Vmax * PDE_cell) / (Km + PDE_cell)) [uM.s-1]
Km (1/2 max)
Km
0.5 [uM]
max reaction rate
Vmax
(kcat * PKA_cell) [uM.s-1]
local
kcat
9.0 [s-1]
Expressions for PP2A_inact_MAPKK_active
reaction rate
J
((Vmax * MAPKK_active_cell) / (Km + MAPKK_active_cell)) [uM.s-1]
Km (1/2 max)
Km
15.66 [uM]
max reaction rate
Vmax
(kcat * PP2A_cell) [uM.s-1]
local
kcat
6.0 [s-1]
Expressions for PKA release by PKI
reaction rate
J
((Kf * inhibitedPKA_cell) - ((Kr * PKI_cell) * PKA_cell)) [uM.s-1]
forward rate constant
Kf
1.0E-4 [s-1]
reverse rate constant
Kr
0.0 [s-1.uM-1]
Expressions for cAMP_binds_A2
reaction rate
J
(((Kf * cAMP3_R2C2_cell) * cAMP_cell) - (Kr * cAMP4_R2C2_cell)) [uM.s-1]
forward rate constant
Kf
75.0 [s-1.uM-1]
reverse rate constant
Kr
32.5 [s-1]
Expressions for BRaf_act_MAPKK
reaction rate
J
((Vmax * MAPKK_cell) / (Km + MAPKK_cell)) [uM.s-1]
Km (1/2 max)
Km
0.159 [uM]
max reaction rate
Vmax
(kcat * BRaf_star_cell) [uM.s-1]
local
kcat
0.105 [s-1]
Expressions for 8a: Rap1-Epac binding
reaction rate
J
(((Kf_8a__Rap1_Epac_binding * Rap1_GDP_GM) * Epac_cAMP_cell) - (Kr_8a__Rap1_Epac_binding * Rap1_Epac_GM)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
forward rate constant
Kf_8a__Rap1_Epac_binding
2.0 [s-1.uM-1]
reverse rate constant
Kr_8a__Rap1_Epac_binding
0.8 [s-1]
Expressions for Epac-cAMP binding
reaction rate
J
(((Kf_06__Epac_cAMP_binding * cAMP_cell) * Epac_cell) - (Kr_06__Epac_cAMP_binding * Epac_cAMP_cell)) [uM.s-1]
forward rate constant
Kf_06__Epac_cAMP_binding
32.0 [s-1.uM-1]
reverse rate constant
Kr_06__Epac_cAMP_binding
96.0 [s-1]
Expressions for GRK-Gbg binding
reaction rate
J
(((Kf * G_bg_PM) * GRK_cell) - (Kr * GRK_Gbg_PM)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
forward rate constant
Kf
1.0 [s-1.uM-1]
reverse rate constant
Kr
0.25 [s-1]
Expressions for MKPp_decat_MAPKtyr
reaction rate
J
((Vmax * MAPK_Thr_cell) / (Km + MAPK_Thr_cell)) [uM.s-1]
Km (1/2 max)
Km
0.067 [uM]
max reaction rate
Vmax
(kcat * MKP1p_cell) [uM.s-1]
local
kcat
1.0 [s-1]
Expressions for MKP1p deact MAPKtyr
reaction rate
J
((Vmax * MAPK_thr_nucleus) / (Km + MAPK_thr_nucleus)) [uM.s-1]
Km (1/2 max)
Km
0.0667 [uM]
max reaction rate
Vmax
(kcat * MKP1p_nucleus) [uM.s-1]
local
kcat
1.0 [s-1]
Expressions for 14b: Gs trimerization
reaction rate
J
(((Kf_14b__Gs_trimerization * Gsa_GDP_PM) * G_bg_PM) - (Kr_14b__Gs_trimerization * Gs_trimer_PM)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
forward rate constant
Kf_14b__Gs_trimerization
0.006 [um2.s-1.molecules-1]
reverse rate constant
Kr_14b__Gs_trimerization
0.0 [s-1]
Expressions for PKA_deact_PTPSL
reaction rate
J
((Vmax * PTPSL_cell) / (Km + PTPSL_cell)) [uM.s-1]
Km (1/2 max)
Km
0.1 [uM]
max reaction rate
Vmax
(kcat * PKA_cell) [uM.s-1]
local
kcat
0.2 [s-1]
Expressions for MSK_act_CREB
reaction rate
J
((Vmax * CREB_nucleus) / (Km + CREB_nucleus)) [uM.s-1]
Km (1/2 max)
Km
2.0 [uM]
max reaction rate
Vmax
(kcat * MSK_active_nucleus) [uM.s-1]
local
kcat
1.5 [s-1]
Expressions for PDE_highKm deact cAMP
reaction rate
J
((Vmax * cAMP_cell) / (Km + cAMP_cell)) [uM.s-1]
Km (1/2 max)
Km
15.0 [uM]
max reaction rate
Vmax
(kcat * PDE_highKm_cell) [uM.s-1]
local
kcat
8.0 [s-1]
Expressions for MSK_dephos
reaction rate
J
((Kf * MSK_active_nucleus) - (Kr * MSK_nucleus)) [uM.s-1]
forward rate constant
Kf
0.04 [s-1]
reverse rate constant
Kr
0.0 [s-1]
Expressions for constit exch+hydrolysis
reaction rate
J
((Kf * Rap1_GDP_GM) - (Kr * Rap1_GTP_GM)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
forward rate constant
Kf
3.0E-6 [s-1]
reverse rate constant
Kr
8.5E-5 [s-1]
Expressions for PKA_act_CREB
reaction rate
J
((Vmax * CREB_nucleus) / (Km + CREB_nucleus)) [uM.s-1]
Km (1/2 max)
Km
17.0 [uM]
max reaction rate
Vmax
(kcat * PKA_nucleus) [uM.s-1]
local
kcat
6.0 [s-1]
Expressions for MAPK dephosph by PTP
reaction rate
J
((Vmax * MAPK_active_cell) / (Km + MAPK_active_cell)) [uM.s-1]
Km (1/2 max)
Km
0.5 [uM]
max reaction rate
Vmax
(kcat * PTPSL_cell) [uM.s-1]
local
kcat
1.0 [s-1]
Expressions for PP1A_dephos_CREB
reaction rate
J
((Vmax * CREB_Ser_nucleus) / (Km + CREB_Ser_nucleus)) [uM.s-1]
Km (1/2 max)
Km
3.0 [uM]
max reaction rate
Vmax
(kcatPP1A * PP1A_nucleus) [uM.s-1]
local
kcatPP1A
0.4 [s-1]
Expressions for MKP1 deact MAPKact
reaction rate
J
((Vmax * MAPK_active_nucleus) / (Km + MAPK_active_nucleus)) [uM.s-1]
Km (1/2 max)
Km
0.0667 [uM]
max reaction rate
Vmax
(kcat * MKP1_nucleus) [uM.s-1]
local
kcat
1.0 [s-1]
Expressions for MKP1 deact MAPKtyr
reaction rate
J
((Vmax * MAPK_thr_nucleus) / (Km + MAPK_thr_nucleus)) [uM.s-1]
Km (1/2 max)
Km
0.0667 [uM]
max reaction rate
Vmax
(kcat * MKP1_nucleus) [uM.s-1]
local
kcat
1.0 [s-1]
Expressions for reaction2
reaction rate
J
((Vmax * MSK_nucleus) / (Km + MSK_nucleus)) [uM.s-1]
Km (1/2 max)
Km
25.0 [uM]
max reaction rate
Vmax
(10.0 * MAPK_active_nucleus) [uM.s-1]
Expressions for MKP2 deact MAPKact
reaction rate
J
((Vmax * MAPK_active_nucleus) / (Km + MAPK_active_nucleus)) [uM.s-1]
Km (1/2 max)
Km
0.0667 [uM]
max reaction rate
Vmax
(kcat * MKP2_nucleus) [uM.s-1]
local
kcat
1.0 [s-1]
Expressions for cAMP_bind_cAMP2R2C2
reaction rate
J
(((Kf * cAMP_cell) * cAMP2_R2C2_cell) - (Kr * cAMP3_R2C2_cell)) [uM.s-1]
forward rate constant
Kf
75.0 [s-1.uM-1]
reverse rate constant
Kr
110.0 [s-1]
Expressions for MKP2 deact MAPK tyr
reaction rate
J
((Vmax * MAPK_thr_nucleus) / (Km + MAPK_thr_nucleus)) [uM.s-1]
Km (1/2 max)
Km
0.0667 [uM]
max reaction rate
Vmax
(kcat * MKP2_nucleus) [uM.s-1]
local
kcat
1.0 [s-1]
Expressions for MKP1 phosph by MAPKactive_nucleus
reaction rate
J
((Vmax * MKP1_nucleus) / (Km + MKP1_nucleus)) [uM.s-1]
Km (1/2 max)
Km
25.641 [uM]
max reaction rate
Vmax
(kcat * MAPK_active_nucleus) [uM.s-1]
local
kcat
1.0 [s-1]
Expressions for MKP1 dephosph in nucleus
reaction rate
J
((Kf * MKP1p_nucleus) - (Kr * MKP1_nucleus)) [uM.s-1]
forward rate constant
Kf
1.0E-4 [s-1]
reverse rate constant
Kr
0.0 [s-1]
Expressions for MKP1_deact_MAPKactive
reaction rate
J
((Vmax * MAPK_active_cell) / (Km + MAPK_active_cell)) [uM.s-1]
Km (1/2 max)
Km
0.0667 [uM]
max reaction rate
Vmax
(kcat * MKP1_cell) [uM.s-1]
local
kcat
1.0 [s-1]
Expressions for 04: Gs-AC binding
reaction rate
J
((AC_PM * Kf_04__Gs_AC_binding * Gs_a_PM) - (Kr_04__Gs_AC_binding * AC_Gsa_PM)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
local
Kf_04__Gs_AC_binding
1.0 [um2.molecules-1.s-1]
local
Kr_04__Gs_AC_binding
3.4 [s-1]
Expressions for 05b: cAMP production
reaction rate
J
((Vmax * ATP_cell) / (Km + ATP_cell)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
Km (1/2 max)
Km
3.15 [uM]
max reaction rate
Vmax
(kcat * AC_Gsa_PM) [molecules.um-2.s-1]
local
kcat
8.5 [s-1]
Expressions for PKA inhibition by PKI
reaction rate
J
(((Kf * PKI_nucleus) * PKA_nucleus) - (Kr * inhibitedPKA_nucleus)) [uM.s-1]
forward rate constant
Kf
1.0 [s-1.uM-1]
reverse rate constant
Kr
1.0E-4 [s-1]
Expressions for cAMP bind R2C2
reaction rate
J
(((Kf * R2C2_cell) * cAMP_cell) - (Kr * cAMP_R2C2_cell)) [uM.s-1]
forward rate constant
Kf
54.0 [s-1.uM-1]
reverse rate constant
Kr
33.0 [s-1]
Expressions for Pp2A_deact_CREB
reaction rate
J
((Vmax * CREB_Ser_nucleus) / (Km + CREB_Ser_nucleus)) [uM.s-1]
Km (1/2 max)
Km
15.66 [uM]
max reaction rate
Vmax
(6.0 * pp2a_nucleus) [uM.s-1]
Expressions for 2: ARbeta-Gs binding
reaction rate
J
(((Kf_2__ARbeta_Gs_binding * beta_isop_PM) * Gs_trimer_PM) - (Kr_2__ARbeta_Gs_binding * betaAR_Gs_PM)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
forward rate constant
Kf_2__ARbeta_Gs_binding
0.01 [um2.s-1.molecules-1]
reverse rate constant
Kr_2__ARbeta_Gs_binding
0.1 [s-1]
Expressions for MAPK_act_MKPtranscription
reaction rate
J
((Vmax * MKP1gene_nucleus) / (Km + MKP1gene_nucleus)) [uM.s-1]
Km (1/2 max)
Km
4.0 [uM]
max reaction rate
Vmax
(kcat * MAPK_active_nucleus) [uM.s-1]
local
kcat
3.0E-4 [s-1]
Expressions for PDEstar_deact_cAMP
reaction rate
J
((Vmax * cAMP_cell) / (Km + cAMP_cell)) [uM.s-1]
Km (1/2 max)
Km
1.3 [uM]
max reaction rate
Vmax
(20.0 * PDE_star_cell) [uM.s-1]
Expressions for 03: GRK activity
reaction rate
J_3__GRK_activity
((beta_isop_PM * GRK_PM * kCATgrk / (KM + beta_isop_PM)) - (beta_P_PM * kdephos)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
local
KM
250.0 [molecules.um-2]
local
kdephos
0.0 [s-1]
local
kCATgrk
0.204 [s-1]
Expressions for Release of C2
reaction rate
J
((Kf * cAMP4_R2C_cell) - ((Kr * cAMP4_R2_cell) * PKA_cell)) [uM.s-1]
forward rate constant
Kf
0.6 [s-1]
reverse rate constant
Kr
0.18 [s-1.uM-1]
Expressions for MKP1 basal transcription
reaction rate
J
((Kf * MKP1gene_nucleus) - (Kr * MKP1_RNA_nucleus)) [uM.s-1]
forward rate constant
Kf
2.0E-6 [s-1]
reverse rate constant
Kr
0.0 [s-1]
Expressions for 10a: Rap1-RGII binding
reaction rate
J
(((Kf_10a__Rap1_RGII_binding * Rap1GAP_cell) * Rap1_GTP_GM) - (Kr_10a__Rap1_RGII_binding * Rap1_RGII_GM)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
forward rate constant
Kf_10a__Rap1_RGII_binding
0.62 [s-1.uM-1]
reverse rate constant
Kr_10a__Rap1_RGII_binding
8.7 [s-1]
Expressions for MKP1 turnover
reaction rate
J
(Kf * MKP1_cell) [uM.s-1]
forward rate constant
Kf
3.7E-4 [s-1]
reverse rate constant
Kr
0.0 [uM.s-1]
Expressions for cAMP_binds_cAMPR2C2
reaction rate
J
(((Kf * cAMP_R2C2_cell) * cAMP_cell) - (Kr * cAMP2_R2C2_cell)) [uM.s-1]
forward rate constant
Kf
54.0 [s-1.uM-1]
reverse rate constant
Kr
33.0 [s-1]
Expressions for Gs GTPase
reaction rate
J
(Gs_a_PM * Kcat) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
local
Kcat
0.11 [s-1]
Expressions for 10: Rap1 GTPase
reaction rate
J_10__Rap1_GTPase
(kcat * Rap1_RGII_GM) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
local
kcat
8.0 [s-1]
Expressions for PP2A_inact_MAPKKSer
reaction rate
J
((Vmax * MAPKK_Ser_cell) / (Km + MAPKK_Ser_cell)) [uM.s-1]
Km (1/2 max)
Km
15.66 [uM]
max reaction rate
Vmax
(kcat * PP2A_cell) [uM.s-1]
local
kcat
6.0 [s-1]
Expressions for MAPKK_act_MAPK
reaction rate
J
((Vmax * MAPK_cell) / (Km + MAPK_cell)) [uM.s-1]
Km (1/2 max)
Km
0.046296 [uM]
max reaction rate
Vmax
(kcat * MAPKK_active_cell) [uM.s-1]
local
kcat
0.15 [s-1]
Expressions for MKP_translation
reaction rate
J
((Kf * MKP1_RNA_cell) - (Kr * MKP1_cell)) [uM.s-1]
forward rate constant
Kf
0.004 [s-1]
reverse rate constant
Kr
0.0 [s-1]
Expressions for reaction1
reaction rate
J
(Vmax * MAPKK_Ser_cell / (Km + MAPKK_Ser_cell)) [uM.s-1]
local
Km
0.159 [uM]
local
Vmax
(kcat * BRaf_star_cell) [uM.s-1]
local
kcat
0.105 [s-1]
Expressions for PP2A_dephos_PDEstar
reaction rate
J
((Vmax * PDE_star_cell) / (Km + PDE_star_cell)) [uM.s-1]
Km (1/2 max)
Km
0.96 [uM]
max reaction rate
Vmax
(0.77 * PDE_PP_cell) [uM.s-1]
Expressions for GRK PM recruitment
reaction rate
J
((Kf_GRK_PM_recruitment * GRK_Gbg_PM) - ((Kr_GRK_PM_recruitment * GRK_PM) * G_bg_PM)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
forward rate constant
Kf_GRK_PM_recruitment
1.0 [s-1]
reverse rate constant
Kr_GRK_PM_recruitment
1.0E-4 [um2.s-1.molecules-1]
Expressions for reaction0
reaction rate
J
((Vmax * MAPK_Thr_cell) / (Km + MAPK_Thr_cell)) [uM.s-1]
Km (1/2 max)
Km
0.06667 [uM]
max reaction rate
Vmax
MKP2_cell [uM.s-1]
Expressions for reaction3
reaction rate
J
((Vmax * MAPK_active_cell) / (Km + MAPK_active_cell)) [uM.s-1]
Km (1/2 max)
Km
0.06667 [uM]
max reaction rate
Vmax
MKP2_cell [uM.s-1]
Expressions for MKP_decat_MAPKtyr
reaction rate
J
((Vmax * MAPK_Thr_cell) / (Km + MAPK_Thr_cell)) [uM.s-1]
Km (1/2 max)
Km
0.067 [uM]
max reaction rate
Vmax
(kcat * MKP1_cell) [uM.s-1]
local
kcat
1.0 [s-1]
Expressions for RapRaf_act_MAPKKSer
reaction rate
J
((Vmax * MAPKK_Ser_cell) / (Km + MAPKK_Ser_cell)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
Km (1/2 max)
Km
0.4 [uM]
max reaction rate
Vmax
(kcat * Rap1_BRaf_GM) [molecules.um-2.s-1]
local
kcat
0.95 [s-1]
Expressions for MKP1p turnover
reaction rate
J
(Kf * MKP1p_cell) [uM.s-1]
forward rate constant
Kf
1.0E-4 [s-1]
reverse rate constant
Kr
0.0 [uM.s-1]
Expressions for MKP1 dephosph
reaction rate
J
((Kf * MKP1p_cell) - (Kr * MKP1_cell)) [uM.s-1]
forward rate constant
Kf
1.0E-4 [s-1]
reverse rate constant
Kr
0.0 [s-1]
Expressions for MKP1p_deact_MAPKactive
reaction rate
J
((Vmax * MAPK_active_cell) / (Km + MAPK_active_cell)) [uM.s-1]
Km (1/2 max)
Km
0.0667 [uM]
max reaction rate
Vmax
(kcat * MKP1p_cell) [uM.s-1]
local
kcat
1.0 [s-1]
Expressions for 02b: Gs activation
reaction rate
J
((Kf * betaAR_Gs_PM) - (((Kr * beta_isop_PM) * Gs_a_PM) * G_bg_PM)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
forward rate constant
Kf
0.025 [s-1]
reverse rate constant
Kr
0.0 [um4.s-1.molecules-2]
Expressions for Rap1_binds_BRaf
reaction rate
J
(((Kf * BRaf_cell) * Rap1_GTP_GM) - (Kr * Rap1_BRaf_GM)) [molecules.um-2.s-1]
inward current density
I
0.0 [pA.um-2]
net charge valence
netValence
0.0 [1]
forward rate constant
Kf
4.0 [s-1.uM-1]
reverse rate constant
Kr
10.0 [s-1]
Structures
| Name | Type | Electrical |
|---|---|---|
| GM | Membrane | golgi(+) cell(-) |
| PM | Membrane | cell(+) ec(-) |
| nuclear membrane | Membrane | nucleus(+) cell(-) |
| cell | Compartment | (+) (-) |
| ec | Compartment | (+) (-) |
| golgi | Compartment | (+) (-) |
| nucleus | Compartment | (+) (-) |
GM Universal ID's
GM Text Annotations
PM Universal ID's
PM Text Annotations
nuclear membrane Universal ID's
nuclear membrane Text Annotations
cell Universal ID's
cell Text Annotations
ec Universal ID's
ec Text Annotations
golgi Universal ID's
golgi Text Annotations
nucleus Universal ID's
nucleus Text Annotations
Species
MSK_nucleus Universal ID's
MSK_nucleus Text Annotations
R2C2_cell Universal ID's
R2C2_cell Text Annotations
ATP_cell Universal ID's
ATP_cell Text Annotations
MKP1_cell Universal ID's
MKP1_cell Text Annotations
MSK_active_nucleus Universal ID's
MSK_active_nucleus Text Annotations
AMP_cell Universal ID's
AMP_cell Text Annotations
BRaf_cell Universal ID's
BRaf_cell Text Annotations
MAPK_act_cell Universal ID's
MAPK_act_cell Text Annotations
cAMP4_R2C2_cell Universal ID's
cAMP4_R2C2_cell Text Annotations
cAMP4_R2C_cell Universal ID's
cAMP4_R2C_cell Text Annotations
cAMP4_R2_cell Universal ID's
cAMP4_R2_cell Text Annotations
MAPK_nucleus Universal ID's
MAPK_nucleus Text Annotations
MKP1_nucleus Universal ID's
MKP1_nucleus Text Annotations
MKP2_nucleus Universal ID's
MKP2_nucleus Text Annotations
MAPK_thr_nucleus Universal ID's
MAPK_thr_nucleus Text Annotations
MKP1p_cell Universal ID's
MKP1p_cell Text Annotations
MKP1p_nucleus Universal ID's
MKP1p_nucleus Text Annotations
MKP2_cell Universal ID's
MKP2_cell Text Annotations
G_bg_PM Universal ID's
G_bg_PM Text Annotations
Rap1_RGII_GM Universal ID's
Rap1_RGII_GM Text Annotations
Gsa_GDP_PM Universal ID's
Gsa_GDP_PM Text Annotations
beta_isop_PM Universal ID's
beta_isop_PM Text Annotations
PDE_star_cell Universal ID's
PDE_star_cell Text Annotations
isoprenaline_ec Universal ID's
isoprenaline_ec Text Annotations
MKP1gene_nucleus Universal ID's
MKP1gene_nucleus Text Annotations
PP2A_cell Universal ID's
PP2A_cell Text Annotations
MAPK_active_nucleus Universal ID's
MAPK_active_nucleus Text Annotations
cAMP_R2C2_cell Universal ID's
cAMP_R2C2_cell Text Annotations
Rap1_GDP_GM Universal ID's
Rap1_GDP_GM Text Annotations
beta_PM Universal ID's
beta_PM Text Annotations
Epac_cAMP_cell Universal ID's
Epac_cAMP_cell Text Annotations
beta_P_PM Universal ID's
beta_P_PM Text Annotations
Rap1_Epac_GM Universal ID's
Rap1_Epac_GM Text Annotations
MKP1_RNA_nucleus Universal ID's
MKP1_RNA_nucleus Text Annotations
cAMP2_R2C2_cell Universal ID's
cAMP2_R2C2_cell Text Annotations
PKA_cell Universal ID's
PKA_cell Text Annotations
MAPKK_Ser_cell Universal ID's
MAPKK_Ser_cell Text Annotations
PKI_cell Universal ID's
PKI_cell Text Annotations
inhibitedPKA_nucleus Universal ID's
inhibitedPKA_nucleus Text Annotations
inhibitedPKA_cell Universal ID's
inhibitedPKA_cell Text Annotations
Gs_trimer_PM Universal ID's
Gs_trimer_PM Text Annotations
GRK_Gbg_PM Universal ID's
GRK_Gbg_PM Text Annotations
Gs_a_PM Universal ID's
Gs_a_PM Text Annotations
MAPK_active_cell Universal ID's
MAPK_active_cell Text Annotations
Rap1GAP_cell Universal ID's
Rap1GAP_cell Text Annotations
MAPKK_cell Universal ID's
MAPKK_cell Text Annotations
cAMP3_R2C2_cell Universal ID's
cAMP3_R2C2_cell Text Annotations
cAMP_cell Universal ID's
cAMP_cell Text Annotations
PP1_cell Universal ID's
PP1_cell Text Annotations
PP1A_nucleus Universal ID's
PP1A_nucleus Text Annotations
CREB_Ser_nucleus Universal ID's
CREB_Ser_nucleus Text Annotations
PTPSL_star_cell Universal ID's
PTPSL_star_cell Text Annotations
Epac_cell Universal ID's
Epac_cell Text Annotations
MKP1_RNA_cell Universal ID's
MKP1_RNA_cell Text Annotations
Rap1_BRaf_GM Universal ID's
Rap1_BRaf_GM Text Annotations
MAPKK_active_cell Universal ID's
MAPKK_active_cell Text Annotations
PKI_nucleus Universal ID's
PKI_nucleus Text Annotations
GRK_cell Universal ID's
GRK_cell Text Annotations
AC_PM Universal ID's
AC_PM Text Annotations
AC_Gsa_PM Universal ID's
AC_Gsa_PM Text Annotations
PDE_cell Universal ID's
PDE_cell Text Annotations
Rap1_GTP_GM Universal ID's
Rap1_GTP_GM Text Annotations
pp2a_nucleus Universal ID's
pp2a_nucleus Text Annotations
CREB_nucleus Universal ID's
CREB_nucleus Text Annotations
PTPSL_cell Universal ID's
PTPSL_cell Text Annotations
MAPK_Thr_cell Universal ID's
MAPK_Thr_cell Text Annotations
PDE_PP_cell Universal ID's
PDE_PP_cell Text Annotations
PDE_highKm_cell Universal ID's
PDE_highKm_cell Text Annotations
GRK_PM Universal ID's
GRK_PM Text Annotations
betaAR_Gs_PM Universal ID's
betaAR_Gs_PM Text Annotations
BRaf_star_cell Universal ID's
BRaf_star_cell Text Annotations
PKA_nucleus Universal ID's
PKA_nucleus Text Annotations
MAPK_cell Universal ID's
MAPK_cell Text Annotations
Applications
| Name | Properties | Math Type | Annotation |
|---|---|---|---|
| Compart |
Specs -
Species Specs - Reaction Simulations |
Deterministic (ODE) Compartmental | cloned from 'Compart' owned by user eungdamr cloned from 'Compart' owned by user argh |
Compart Universal ID's
Compart Text Annotations
Specifications (Species) - Compart go to Simulations
| Species | Initial Condition | Diffusion Constant | Structure |
|---|---|---|---|
| R2C2_cell | 0.2 [uM] | 0.0 [um2/s] | cell |
| ATP_cell | 4000.0 [uM] | 0.0 [um2/s] | cell |
| MKP1_cell | 3.6E-4 [uM] | 0.0 [um2/s] | cell |
| AMP_cell | 1.0E-6 [uM] | 0.0 [um2/s] | cell |
| BRaf_cell | 0.2 [uM] | 0.0 [um2/s] | cell |
| MAPK_act_cell | 0.0 [uM] | 0.0 [um2/s] | cell |
| cAMP4_R2C2_cell | 0.0 [uM] | 0.0 [um2/s] | cell |
| cAMP4_R2C_cell | 0.0 [uM] | 0.0 [um2/s] | cell |
| cAMP4_R2_cell | 0.0 [uM] | 0.0 [um2/s] | cell |
| MKP1p_cell | 0.0 [uM] | 0.0 [um2/s] | cell |
| MKP2_cell | 0.001 [uM] | 0.0 [um2/s] | cell |
| PDE_star_cell | 0.0 [uM] | 0.0 [um2/s] | cell |
| PP2A_cell | 0.075 [uM] | 0.0 [um2/s] | cell |
| cAMP_R2C2_cell | 0.0 [uM] | 0.0 [um2/s] | cell |
| Epac_cAMP_cell | 1.0E-6 [uM] | 0.0 [um2/s] | cell |
| cAMP2_R2C2_cell | 0.0 [uM] | 0.0 [um2/s] | cell |
| PKA_cell | 0.0 [uM] | 0.0 [um2/s] | cell |
| MAPKK_Ser_cell | 1.0E-6 [uM] | 0.0 [um2/s] | cell |
| PKI_cell | 0.4 [uM] | 0.0 [um2/s] | cell |
| inhibitedPKA_cell | 0.0 [uM] | 0.0 [um2/s] | cell |
| MAPK_active_cell | 0.0 [uM] | 0.0 [um2/s] | cell |
| Rap1GAP_cell | 0.15 [uM] | 0.0 [um2/s] | cell |
| MAPKK_cell | 0.18 [uM] | 0.0 [um2/s] | cell |
| cAMP3_R2C2_cell | 0.0 [uM] | 0.0 [um2/s] | cell |
| cAMP_cell | 1.0E-4 [uM] | 0.0 [um2/s] | cell |
| PP1_cell | 0.04 [uM] | 0.0 [um2/s] | cell |
| PTPSL_star_cell | 0.0 [uM] | 0.0 [um2/s] | cell |
| Epac_cell | 0.16 [uM] | 0.0 [um2/s] | cell |
| MKP1_RNA_cell | 4.0E-5 [uM] | 0.0 [um2/s] | cell |
| MAPKK_active_cell | 1.0E-6 [uM] | 0.0 [um2/s] | cell |
| GRK_cell | 0.045 [uM] | 0.0 [um2/s] | cell |
| PDE_cell | 0.4 [uM] | 0.0 [um2/s] | cell |
| PTPSL_cell | 0.01 [uM] | 0.0 [um2/s] | cell |
| MAPK_Thr_cell | 0.0 [uM] | 0.0 [um2/s] | cell |
| PDE_PP_cell | 0.2 [uM] | 0.0 [um2/s] | cell |
| PDE_highKm_cell | 0.5 [uM] | 0.0 [um2/s] | cell |
| BRaf_star_cell | 0.0 [uM] | 0.0 [um2/s] | cell |
| MAPK_cell | 0.263 [uM] | 0.0 [um2/s] | cell |
| isoprenaline_ec | 10.0 [uM] | 0.0 [um2/s] | ec |
| MSK_nucleus | 0.1 [uM] | 0.0 [um2/s] | nucleus |
| MSK_active_nucleus | 0.0 [uM] | 0.0 [um2/s] | nucleus |
| MAPK_nucleus | 0.233 [uM] | 0.0 [um2/s] | nucleus |
| MKP1_nucleus | 2.2E-4 [uM] | 0.0 [um2/s] | nucleus |
| MKP2_nucleus | 1.0E-4 [uM] | 0.0 [um2/s] | nucleus |
| MAPK_thr_nucleus | 0.0 [uM] | 0.0 [um2/s] | nucleus |
| MKP1p_nucleus | 0.0 [uM] | 0.0 [um2/s] | nucleus |
| MKP1gene_nucleus | 0.2 [uM] | 0.0 [um2/s] | nucleus |
| MAPK_active_nucleus | 0.0 [uM] | 0.0 [um2/s] | nucleus |
| MKP1_RNA_nucleus | 6.5E-7 [uM] | 0.0 [um2/s] | nucleus |
| inhibitedPKA_nucleus | 0.0 [uM] | 0.0 [um2/s] | nucleus |
| PP1A_nucleus | 0.04 [uM] | 0.0 [um2/s] | nucleus |
| CREB_Ser_nucleus | 0.0 [uM] | 0.0 [um2/s] | nucleus |
| PKI_nucleus | 0.0 [uM] | 0.0 [um2/s] | nucleus |
| pp2a_nucleus | 0.05 [uM] | 0.0 [um2/s] | nucleus |
| CREB_nucleus | 0.3 [uM] | 0.0 [um2/s] | nucleus |
| PKA_nucleus | 0.0 [uM] | 0.0 [um2/s] | nucleus |
| Rap1_RGII_GM | 0.0 [uM] | 0.0 [um2/s] | GM |
| Rap1_GDP_GM | 100.0 [uM] | 0.0 [um2/s] | GM |
| Rap1_Epac_GM | 0.0 [uM] | 0.0 [um2/s] | GM |
| Rap1_BRaf_GM | 0.0 [uM] | 0.0 [um2/s] | GM |
| Rap1_GTP_GM | 0.0 [uM] | 0.0 [um2/s] | GM |
| G_bg_PM | 0.0 [uM] | 0.0 [um2/s] | PM |
| Gsa_GDP_PM | 1.0E-6 [uM] | 0.0 [um2/s] | PM |
| beta_isop_PM | 1.0E-6 [uM] | 0.0 [um2/s] | PM |
| beta_PM | 33.0 [uM] | 0.0 [um2/s] | PM |
| beta_P_PM | 1.0E-6 [uM] | 0.0 [um2/s] | PM |
| Gs_trimer_PM | 100.0 [uM] | 0.0 [um2/s] | PM |
| GRK_Gbg_PM | 0.0 [uM] | 0.0 [um2/s] | PM |
| Gs_a_PM | 1.0E-6 [uM] | 0.0 [um2/s] | PM |
| AC_PM | 100.0 [uM] | 0.0 [um2/s] | PM |
| AC_Gsa_PM | 1.0E-6 [uM] | 0.0 [um2/s] | PM |
| GRK_PM | 1.0E-6 [uM] | 0.0 [um2/s] | PM |
| betaAR_Gs_PM | 0.0 [uM] | 0.0 [um2/s] | PM |
Specifications (Reaction) - Compart go to Simulations
| Name | Enabled? |
|---|---|
| PP_deact_BRaf | included |
| PKA_act_BRaf | included |
| GRK to cytosol | included |
| 08: Epac exchange | included |
| Release of C1 | included |
| Rap1raf_act_MAPKK | included |
| MKP1 phospho by MAPKactive | included |
| MKP1p turnover nucleus | included |
| 07: PDE | included |
| MKP1p deact MAPKact | included |
| MKP1 turnover in nucleus | included |
| 01b: isoprenaline binding | included |
| PTPSL_dephos | included |
| MAPKK_act_MAPK_thr | included |
| Receptor recycling | included |
| PKA_act_PDE | included |
| PP2A_inact_MAPKK_active | included |
| PKA release by PKI | included |
| cAMP_binds_A2 | included |
| BRaf_act_MAPKK | included |
| 8a: Rap1-Epac binding | included |
| Epac-cAMP binding | included |
| GRK-Gbg binding | included |
| MKPp_decat_MAPKtyr | included |
| MKP1p deact MAPKtyr | included |
| 14b: Gs trimerization | included |
| PKA_deact_PTPSL | included |
| MSK_act_CREB | included |
| PDE_highKm deact cAMP | included |
| MSK_dephos | included |
| constit exch+hydrolysis | included |
| PKA_act_CREB | included |
| MAPK dephosph by PTP | included |
| PP1A_dephos_CREB | included |
| MKP1 deact MAPKact | included |
| MKP1 deact MAPKtyr | included |
| reaction2 | included |
| MKP2 deact MAPKact | included |
| cAMP_bind_cAMP2R2C2 | included |
| MKP2 deact MAPK tyr | included |
| MKP1 phosph by MAPKactive_nucleus | included |
| MKP1 dephosph in nucleus | included |
| MKP1_deact_MAPKactive | included |
| 04: Gs-AC binding | included |
| 05b: cAMP production | included |
| PKA inhibition by PKI | included |
| cAMP bind R2C2 | included |
| Pp2A_deact_CREB | included |
| 2: ARbeta-Gs binding | included |
| MAPK_act_MKPtranscription | included |
| PDEstar_deact_cAMP | included |
| 03: GRK activity | included |
| Release of C2 | included |
| MKP1 basal transcription | included |
| 10a: Rap1-RGII binding | included |
| MKP1 turnover | included |
| cAMP_binds_cAMPR2C2 | included |
| Gs GTPase | included |
| 10: Rap1 GTPase | included |
| PP2A_inact_MAPKKSer | included |
| MAPKK_act_MAPK | included |
| MKP_translation | included |
| reaction1 | included |
| PP2A_dephos_PDEstar | included |
| GRK PM recruitment | included |
| reaction0 | included |
| reaction3 | included |
| MKP_decat_MAPKtyr | included |
| RapRaf_act_MAPKKSer | included |
| MKP1p turnover | included |
| MKP1 dephosph | included |
| MKP1p_deact_MAPKactive | included |
| 02b: Gs activation | included |
| Rap1_binds_BRaf | included |
| PKI translocation | included |
| MKP1p translocation | included |
| MAPK translocation | included |
| MKP1 translocation | included |
| MAPKactive_translocation | included |
| PKA_translocation | included |
| inhibited PKA export | included |
| MKPRNA_export | included |
Simulations - Compart go to Specifications
| Name | End Time | Output Options |
|---|---|---|
| iso | 3000.0 |
OutputTimes 0.0,0.01,0.02,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9,1.0,1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8,1.9,2.0,2.1,2.2,2.3,2.4,2.5,2.6,2.7,2.8,2.9,3.0,3.1,3.2,3.3,3.4,3.5,3.6,3.7,3.8,3.9,4.0,4.1,4.2,4.3,4.4,4.5,4.6,4.7,4.8,4.9,5.0,6.0,7.0,8.0,9.0,10.0,11.0,12.0,13.0,14.0,15.0,16.0,17.0,18.0,19.0,20.0,21.0,22.0,23.0,24.0,25.0,26.0,27.0,28.0,29.0,30.0,31.0,32.0,33.0,34.0,35.0,36.0,37.0,38.0,39.0,40.0,41.0,42.0,43.0,44.0,45.0,46.0,47.0,48.0,49.0,50.0,51.0,52.0,53.0,54.0,55.0,56.0,57.0,58.0,59.0,60.0,65.0,70.0,75.0,80.0,85.0,90.0,95.0,100.0,105.0,110.0,115.0,120.0,125.0,130.0,135.0,140.0,145.0,150.0,155.0,160.0,165.0,170.0,175.0,180.0,185.0,190.0,195.0,200.0,205.0,210.0,215.0,220.0,225.0,230.0,235.0,240.0,245.0,250.0,255.0,260.0,265.0,270.0,275.0,280.0,285.0,290.0,295.0,300.0,330.0,360.0,390.0,420.0,450.0,480.0,510.0,540.0,570.0,600.0,630.0,660.0,690.0,720.0,750.0,780.0,810.0,840.0,870.0,900.0,930.0,960.0,990.0,1020.0,1050.0,1080.0,1110.0,1140.0,1170.0,1200.0,1230.0,1260.0,1290.0,1320.0,1350.0,1380.0,1410.0,1440.0,1470.0,1500.0,1530.0,1560.0,1590.0,1620.0,1650.0,1680.0,1710.0,1740.0,1770.0,1800.0,1830.0,1860.0,1890.0,1920.0,1950.0,1980.0,2010.0,2040.0,2070.0,2100.0,2130.0,2160.0,2190.0,2220.0,2250.0,2280.0,2310.0,2340.0,2370.0,2400.0,2430.0,2460.0,2490.0,2520.0,2550.0,2580.0,2610.0,2640.0,2670.0,2700.0,2730.0,2760.0,2790.0,2820.0,2850.0,2880.0,2910.0,2940.0,2970.0,3000.0 |
| rpcamp | 3000.0 |
OutputTimes 0.0,0.01,0.02,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9,1.0,1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8,1.9,2.0,2.1,2.2,2.3,2.4,2.5,2.6,2.7,2.8,2.9,3.0,3.1,3.2,3.3,3.4,3.5,3.6,3.7,3.8,3.9,4.0,4.1,4.2,4.3,4.4,4.5,4.6,4.7,4.8,4.9,5.0,6.0,7.0,8.0,9.0,10.0,11.0,12.0,13.0,14.0,15.0,16.0,17.0,18.0,19.0,20.0,21.0,22.0,23.0,24.0,25.0,26.0,27.0,28.0,29.0,30.0,31.0,32.0,33.0,34.0,35.0,36.0,37.0,38.0,39.0,40.0,41.0,42.0,43.0,44.0,45.0,46.0,47.0,48.0,49.0,50.0,51.0,52.0,53.0,54.0,55.0,56.0,57.0,58.0,59.0,60.0,65.0,70.0,75.0,80.0,85.0,90.0,95.0,100.0,105.0,110.0,115.0,120.0,125.0,130.0,135.0,140.0,145.0,150.0,155.0,160.0,165.0,170.0,175.0,180.0,185.0,190.0,195.0,200.0,205.0,210.0,215.0,220.0,225.0,230.0,235.0,240.0,245.0,250.0,255.0,260.0,265.0,270.0,275.0,280.0,285.0,290.0,295.0,300.0,330.0,360.0,390.0,420.0,450.0,480.0,510.0,540.0,570.0,600.0,630.0,660.0,690.0,720.0,750.0,780.0,810.0,840.0,870.0,900.0,930.0,960.0,990.0,1020.0,1050.0,1080.0,1110.0,1140.0,1170.0,1200.0,1230.0,1260.0,1290.0,1320.0,1350.0,1380.0,1410.0,1440.0,1470.0,1500.0,1530.0,1560.0,1590.0,1620.0,1650.0,1680.0,1710.0,1740.0,1770.0,1800.0,1830.0,1860.0,1890.0,1920.0,1950.0,1980.0,2010.0,2040.0,2070.0,2100.0,2130.0,2160.0,2190.0,2220.0,2250.0,2280.0,2310.0,2340.0,2370.0,2400.0,2430.0,2460.0,2490.0,2520.0,2550.0,2580.0,2610.0,2640.0,2670.0,2700.0,2730.0,2760.0,2790.0,2820.0,2850.0,2880.0,2910.0,2940.0,2970.0,3000.0 |
| U0126 | 3000.0 |
OutputTimes 0.0,0.01,0.02,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9,1.0,1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8,1.9,2.0,2.1,2.2,2.3,2.4,2.5,2.6,2.7,2.8,2.9,3.0,3.1,3.2,3.3,3.4,3.5,3.6,3.7,3.8,3.9,4.0,4.1,4.2,4.3,4.4,4.5,4.6,4.7,4.8,4.9,5.0,6.0,7.0,8.0,9.0,10.0,11.0,12.0,13.0,14.0,15.0,16.0,17.0,18.0,19.0,20.0,21.0,22.0,23.0,24.0,25.0,26.0,27.0,28.0,29.0,30.0,31.0,32.0,33.0,34.0,35.0,36.0,37.0,38.0,39.0,40.0,41.0,42.0,43.0,44.0,45.0,46.0,47.0,48.0,49.0,50.0,51.0,52.0,53.0,54.0,55.0,56.0,57.0,58.0,59.0,60.0,65.0,70.0,75.0,80.0,85.0,90.0,95.0,100.0,105.0,110.0,115.0,120.0,125.0,130.0,135.0,140.0,145.0,150.0,155.0,160.0,165.0,170.0,175.0,180.0,185.0,190.0,195.0,200.0,205.0,210.0,215.0,220.0,225.0,230.0,235.0,240.0,245.0,250.0,255.0,260.0,265.0,270.0,275.0,280.0,285.0,290.0,295.0,300.0,330.0,360.0,390.0,420.0,450.0,480.0,510.0,540.0,570.0,600.0,630.0,660.0,690.0,720.0,750.0,780.0,810.0,840.0,870.0,900.0,930.0,960.0,990.0,1020.0,1050.0,1080.0,1110.0,1140.0,1170.0,1200.0,1230.0,1260.0,1290.0,1320.0,1350.0,1380.0,1410.0,1440.0,1470.0,1500.0,1530.0,1560.0,1590.0,1620.0,1650.0,1680.0,1710.0,1740.0,1770.0,1800.0,1830.0,1860.0,1890.0,1920.0,1950.0,1980.0,2010.0,2040.0,2070.0,2100.0,2130.0,2160.0,2190.0,2220.0,2250.0,2280.0,2310.0,2340.0,2370.0,2400.0,2430.0,2460.0,2490.0,2520.0,2550.0,2580.0,2610.0,2640.0,2670.0,2700.0,2730.0,2760.0,2790.0,2820.0,2850.0,2880.0,2910.0,2940.0,2970.0,3000.0 |
| baseline | 30000.0 |
OutputTimes 0.0,0.01,0.02,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9,1.0,1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8,1.9,2.0,2.1,2.2,2.3,2.4,2.5,2.6,2.7,2.8,2.9,3.0,3.1,3.2,3.3,3.4,3.5,3.6,3.7,3.8,3.9,4.0,4.1,4.2,4.3,4.4,4.5,4.6,4.7,4.8,4.9,5.0,6.0,7.0,8.0,9.0,10.0,11.0,12.0,13.0,14.0,15.0,16.0,17.0,18.0,19.0,20.0,21.0,22.0,23.0,24.0,25.0,26.0,27.0,28.0,29.0,30.0,31.0,32.0,33.0,34.0,35.0,36.0,37.0,38.0,39.0,40.0,41.0,42.0,43.0,44.0,45.0,46.0,47.0,48.0,49.0,50.0,51.0,52.0,53.0,54.0,55.0,56.0,57.0,58.0,59.0,60.0,65.0,70.0,75.0,80.0,85.0,90.0,95.0,100.0,105.0,110.0,115.0,120.0,125.0,130.0,135.0,140.0,145.0,150.0,155.0,160.0,165.0,170.0,175.0,180.0,185.0,190.0,195.0,200.0,205.0,210.0,215.0,220.0,225.0,230.0,235.0,240.0,245.0,250.0,255.0,260.0,265.0,270.0,275.0,280.0,285.0,290.0,295.0,300.0,330.0,360.0,390.0,420.0,450.0,480.0,510.0,540.0,570.0,600.0,630.0,660.0,690.0,720.0,750.0,780.0,810.0,840.0,870.0,900.0,930.0,960.0,990.0,1020.0,1050.0,1080.0,1110.0,1140.0,1170.0,1200.0,1230.0,1260.0,1290.0,1320.0,1350.0,1380.0,1410.0,1440.0,1470.0,1500.0,1530.0,1560.0,1590.0,1620.0,1650.0,1680.0,1710.0,1740.0,1770.0,1800.0,1830.0,1860.0,1890.0,1920.0,1950.0,1980.0,2010.0,2040.0,2070.0,2100.0,2130.0,2160.0,2190.0,2220.0,2250.0,2280.0,2310.0,2340.0,2370.0,2400.0,2430.0,2460.0,2490.0,2520.0,2550.0,2580.0,2610.0,2640.0,2670.0,2700.0,2730.0,2760.0,2790.0,2820.0,2850.0,2880.0,2910.0,2940.0,2970.0,3000.0 |
| Rolipram + U0216 | 3000.0 |
OutputTimes 0.0,0.01,0.02,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9,1.0,1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8,1.9,2.0,2.1,2.2,2.3,2.4,2.5,2.6,2.7,2.8,2.9,3.0,3.1,3.2,3.3,3.4,3.5,3.6,3.7,3.8,3.9,4.0,4.1,4.2,4.3,4.4,4.5,4.6,4.7,4.8,4.9,5.0,6.0,7.0,8.0,9.0,10.0,11.0,12.0,13.0,14.0,15.0,16.0,17.0,18.0,19.0,20.0,21.0,22.0,23.0,24.0,25.0,26.0,27.0,28.0,29.0,30.0,31.0,32.0,33.0,34.0,35.0,36.0,37.0,38.0,39.0,40.0,41.0,42.0,43.0,44.0,45.0,46.0,47.0,48.0,49.0,50.0,51.0,52.0,53.0,54.0,55.0,56.0,57.0,58.0,59.0,60.0,65.0,70.0,75.0,80.0,85.0,90.0,95.0,100.0,105.0,110.0,115.0,120.0,125.0,130.0,135.0,140.0,145.0,150.0,155.0,160.0,165.0,170.0,175.0,180.0,185.0,190.0,195.0,200.0,205.0,210.0,215.0,220.0,225.0,230.0,235.0,240.0,245.0,250.0,255.0,260.0,265.0,270.0,275.0,280.0,285.0,290.0,295.0,300.0,330.0,360.0,390.0,420.0,450.0,480.0,510.0,540.0,570.0,600.0,630.0,660.0,690.0,720.0,750.0,780.0,810.0,840.0,870.0,900.0,930.0,960.0,990.0,1020.0,1050.0,1080.0,1110.0,1140.0,1170.0,1200.0,1230.0,1260.0,1290.0,1320.0,1350.0,1380.0,1410.0,1440.0,1470.0,1500.0,1530.0,1560.0,1590.0,1620.0,1650.0,1680.0,1710.0,1740.0,1770.0,1800.0,1830.0,1860.0,1890.0,1920.0,1950.0,1980.0,2010.0,2040.0,2070.0,2100.0,2130.0,2160.0,2190.0,2220.0,2250.0,2280.0,2310.0,2340.0,2370.0,2400.0,2430.0,2460.0,2490.0,2520.0,2550.0,2580.0,2610.0,2640.0,2670.0,2700.0,2730.0,2760.0,2790.0,2820.0,2850.0,2880.0,2910.0,2940.0,2970.0,3000.0 |
| Rolipram2 | 3000.0 |
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| Removal of EPAC | 2700.0 |
OutputTimes 0.0,0.01,0.02,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9,1.0,1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8,1.9,2.0,2.1,2.2,2.3,2.4,2.5,2.6,2.7,2.8,2.9,3.0,3.1,3.2,3.3,3.4,3.5,3.6,3.7,3.8,3.9,4.0,4.1,4.2,4.3,4.4,4.5,4.6,4.7,4.8,4.9,5.0,6.0,7.0,8.0,9.0,10.0,11.0,12.0,13.0,14.0,15.0,16.0,17.0,18.0,19.0,20.0,21.0,22.0,23.0,24.0,25.0,26.0,27.0,28.0,29.0,30.0,31.0,32.0,33.0,34.0,35.0,36.0,37.0,38.0,39.0,40.0,41.0,42.0,43.0,44.0,45.0,46.0,47.0,48.0,49.0,50.0,51.0,52.0,53.0,54.0,55.0,56.0,57.0,58.0,59.0,60.0,65.0,70.0,75.0,80.0,85.0,90.0,95.0,100.0,105.0,110.0,115.0,120.0,125.0,130.0,135.0,140.0,145.0,150.0,155.0,160.0,165.0,170.0,175.0,180.0,185.0,190.0,195.0,200.0,205.0,210.0,215.0,220.0,225.0,230.0,235.0,240.0,245.0,250.0,255.0,260.0,265.0,270.0,275.0,280.0,285.0,290.0,295.0,300.0,330.0,360.0,390.0,420.0,450.0,480.0,510.0,540.0,570.0,600.0,630.0,660.0,690.0,720.0,750.0,780.0,810.0,840.0,870.0,900.0,930.0,960.0,990.0,1020.0,1050.0,1080.0,1110.0,1140.0,1170.0,1200.0,1230.0,1260.0,1290.0,1320.0,1350.0,1380.0,1410.0,1440.0,1470.0,1500.0,1530.0,1560.0,1590.0,1620.0,1650.0,1680.0,1710.0,1740.0,1770.0,1800.0,1830.0,1860.0,1890.0,1920.0,1950.0,1980.0,2010.0,2040.0,2070.0,2100.0,2130.0,2160.0,2190.0,2220.0,2250.0,2280.0,2310.0,2340.0,2370.0,2400.0,2430.0,2460.0,2490.0,2520.0,2550.0,2580.0,2610.0,2640.0,2670.0,2700.0,2730.0,2760.0,2790.0,2820.0,2850.0,2880.0,2910.0,2940.0,2970.0,3000.0 |
| Removal of bRaf activation by PKA | 2700.0 |
OutputTimes 0.0,0.01,0.02,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9,1.0,1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8,1.9,2.0,2.1,2.2,2.3,2.4,2.5,2.6,2.7,2.8,2.9,3.0,3.1,3.2,3.3,3.4,3.5,3.6,3.7,3.8,3.9,4.0,4.1,4.2,4.3,4.4,4.5,4.6,4.7,4.8,4.9,5.0,6.0,7.0,8.0,9.0,10.0,11.0,12.0,13.0,14.0,15.0,16.0,17.0,18.0,19.0,20.0,21.0,22.0,23.0,24.0,25.0,26.0,27.0,28.0,29.0,30.0,31.0,32.0,33.0,34.0,35.0,36.0,37.0,38.0,39.0,40.0,41.0,42.0,43.0,44.0,45.0,46.0,47.0,48.0,49.0,50.0,51.0,52.0,53.0,54.0,55.0,56.0,57.0,58.0,59.0,60.0,65.0,70.0,75.0,80.0,85.0,90.0,95.0,100.0,105.0,110.0,115.0,120.0,125.0,130.0,135.0,140.0,145.0,150.0,155.0,160.0,165.0,170.0,175.0,180.0,185.0,190.0,195.0,200.0,205.0,210.0,215.0,220.0,225.0,230.0,235.0,240.0,245.0,250.0,255.0,260.0,265.0,270.0,275.0,280.0,285.0,290.0,295.0,300.0,330.0,360.0,390.0,420.0,450.0,480.0,510.0,540.0,570.0,600.0,630.0,660.0,690.0,720.0,750.0,780.0,810.0,840.0,870.0,900.0,930.0,960.0,990.0,1020.0,1050.0,1080.0,1110.0,1140.0,1170.0,1200.0,1230.0,1260.0,1290.0,1320.0,1350.0,1380.0,1410.0,1440.0,1470.0,1500.0,1530.0,1560.0,1590.0,1620.0,1650.0,1680.0,1710.0,1740.0,1770.0,1800.0,1830.0,1860.0,1890.0,1920.0,1950.0,1980.0,2010.0,2040.0,2070.0,2100.0,2130.0,2160.0,2190.0,2220.0,2250.0,2280.0,2310.0,2340.0,2370.0,2400.0,2430.0,2460.0,2490.0,2520.0,2550.0,2580.0,2610.0,2640.0,2670.0,2700.0,2730.0,2760.0,2790.0,2820.0,2850.0,2880.0,2910.0,2940.0,2970.0,3000.0 |
| Iso 2 | 2700.0 |
OutputTimes 0.0,0.01,0.02,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9,1.0,1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8,1.9,2.0,2.1,2.2,2.3,2.4,2.5,2.6,2.7,2.8,2.9,3.0,3.1,3.2,3.3,3.4,3.5,3.6,3.7,3.8,3.9,4.0,4.1,4.2,4.3,4.4,4.5,4.6,4.7,4.8,4.9,5.0,6.0,7.0,8.0,9.0,10.0,11.0,12.0,13.0,14.0,15.0,16.0,17.0,18.0,19.0,20.0,21.0,22.0,23.0,24.0,25.0,26.0,27.0,28.0,29.0,30.0,31.0,32.0,33.0,34.0,35.0,36.0,37.0,38.0,39.0,40.0,41.0,42.0,43.0,44.0,45.0,46.0,47.0,48.0,49.0,50.0,51.0,52.0,53.0,54.0,55.0,56.0,57.0,58.0,59.0,60.0,65.0,70.0,75.0,80.0,85.0,90.0,95.0,100.0,105.0,110.0,115.0,120.0,125.0,130.0,135.0,140.0,145.0,150.0,155.0,160.0,165.0,170.0,175.0,180.0,185.0,190.0,195.0,200.0,205.0,210.0,215.0,220.0,225.0,230.0,235.0,240.0,245.0,250.0,255.0,260.0,265.0,270.0,275.0,280.0,285.0,290.0,295.0,300.0,330.0,360.0,390.0,420.0,450.0,480.0,510.0,540.0,570.0,600.0,630.0,660.0,690.0,720.0,750.0,780.0,810.0,840.0,870.0,900.0,930.0,960.0,990.0,1020.0,1050.0,1080.0,1110.0,1140.0,1170.0,1200.0,1230.0,1260.0,1290.0,1320.0,1350.0,1380.0,1410.0,1440.0,1470.0,1500.0,1530.0,1560.0,1590.0,1620.0,1650.0,1680.0,1710.0,1740.0,1770.0,1800.0,1830.0,1860.0,1890.0,1920.0,1950.0,1980.0,2010.0,2040.0,2070.0,2100.0,2130.0,2160.0,2190.0,2220.0,2250.0,2280.0,2310.0,2340.0,2370.0,2400.0,2430.0,2460.0,2490.0,2520.0,2550.0,2580.0,2610.0,2640.0,2670.0,2700.0,2730.0,2760.0,2790.0,2820.0,2850.0,2880.0,2910.0,2940.0,2970.0,3000.0 |
| Removal of PKA | 2700.0 |
OutputTimes 0.0,0.01,0.02,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9,1.0,1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8,1.9,2.0,2.1,2.2,2.3,2.4,2.5,2.6,2.7,2.8,2.9,3.0,3.1,3.2,3.3,3.4,3.5,3.6,3.7,3.8,3.9,4.0,4.1,4.2,4.3,4.4,4.5,4.6,4.7,4.8,4.9,5.0,6.0,7.0,8.0,9.0,10.0,11.0,12.0,13.0,14.0,15.0,16.0,17.0,18.0,19.0,20.0,21.0,22.0,23.0,24.0,25.0,26.0,27.0,28.0,29.0,30.0,31.0,32.0,33.0,34.0,35.0,36.0,37.0,38.0,39.0,40.0,41.0,42.0,43.0,44.0,45.0,46.0,47.0,48.0,49.0,50.0,51.0,52.0,53.0,54.0,55.0,56.0,57.0,58.0,59.0,60.0,65.0,70.0,75.0,80.0,85.0,90.0,95.0,100.0,105.0,110.0,115.0,120.0,125.0,130.0,135.0,140.0,145.0,150.0,155.0,160.0,165.0,170.0,175.0,180.0,185.0,190.0,195.0,200.0,205.0,210.0,215.0,220.0,225.0,230.0,235.0,240.0,245.0,250.0,255.0,260.0,265.0,270.0,275.0,280.0,285.0,290.0,295.0,300.0,330.0,360.0,390.0,420.0,450.0,480.0,510.0,540.0,570.0,600.0,630.0,660.0,690.0,720.0,750.0,780.0,810.0,840.0,870.0,900.0,930.0,960.0,990.0,1020.0,1050.0,1080.0,1110.0,1140.0,1170.0,1200.0,1230.0,1260.0,1290.0,1320.0,1350.0,1380.0,1410.0,1440.0,1470.0,1500.0,1530.0,1560.0,1590.0,1620.0,1650.0,1680.0,1710.0,1740.0,1770.0,1800.0,1830.0,1860.0,1890.0,1920.0,1950.0,1980.0,2010.0,2040.0,2070.0,2100.0,2130.0,2160.0,2190.0,2220.0,2250.0,2280.0,2310.0,2340.0,2370.0,2400.0,2430.0,2460.0,2490.0,2520.0,2550.0,2580.0,2610.0,2640.0,2670.0,2700.0,2730.0,2760.0,2790.0,2820.0,2850.0,2880.0,2910.0,2940.0,2970.0,3000.0 |
| Removal of PKA deact PTP | 2700.0 |
OutputTimes 0.0,0.01,0.02,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9,1.0,1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8,1.9,2.0,2.1,2.2,2.3,2.4,2.5,2.6,2.7,2.8,2.9,3.0,3.1,3.2,3.3,3.4,3.5,3.6,3.7,3.8,3.9,4.0,4.1,4.2,4.3,4.4,4.5,4.6,4.7,4.8,4.9,5.0,6.0,7.0,8.0,9.0,10.0,11.0,12.0,13.0,14.0,15.0,16.0,17.0,18.0,19.0,20.0,21.0,22.0,23.0,24.0,25.0,26.0,27.0,28.0,29.0,30.0,31.0,32.0,33.0,34.0,35.0,36.0,37.0,38.0,39.0,40.0,41.0,42.0,43.0,44.0,45.0,46.0,47.0,48.0,49.0,50.0,51.0,52.0,53.0,54.0,55.0,56.0,57.0,58.0,59.0,60.0,65.0,70.0,75.0,80.0,85.0,90.0,95.0,100.0,105.0,110.0,115.0,120.0,125.0,130.0,135.0,140.0,145.0,150.0,155.0,160.0,165.0,170.0,175.0,180.0,185.0,190.0,195.0,200.0,205.0,210.0,215.0,220.0,225.0,230.0,235.0,240.0,245.0,250.0,255.0,260.0,265.0,270.0,275.0,280.0,285.0,290.0,295.0,300.0,330.0,360.0,390.0,420.0,450.0,480.0,510.0,540.0,570.0,600.0,630.0,660.0,690.0,720.0,750.0,780.0,810.0,840.0,870.0,900.0,930.0,960.0,990.0,1020.0,1050.0,1080.0,1110.0,1140.0,1170.0,1200.0,1230.0,1260.0,1290.0,1320.0,1350.0,1380.0,1410.0,1440.0,1470.0,1500.0,1530.0,1560.0,1590.0,1620.0,1650.0,1680.0,1710.0,1740.0,1770.0,1800.0,1830.0,1860.0,1890.0,1920.0,1950.0,1980.0,2010.0,2040.0,2070.0,2100.0,2130.0,2160.0,2190.0,2220.0,2250.0,2280.0,2310.0,2340.0,2370.0,2400.0,2430.0,2460.0,2490.0,2520.0,2550.0,2580.0,2610.0,2640.0,2670.0,2700.0,2730.0,2760.0,2790.0,2820.0,2850.0,2880.0,2910.0,2940.0,2970.0,3000.0 |
| Removal of MSK | 2700.0 |
OutputTimes 0.0,0.01,0.02,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9,1.0,1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8,1.9,2.0,2.1,2.2,2.3,2.4,2.5,2.6,2.7,2.8,2.9,3.0,3.1,3.2,3.3,3.4,3.5,3.6,3.7,3.8,3.9,4.0,4.1,4.2,4.3,4.4,4.5,4.6,4.7,4.8,4.9,5.0,6.0,7.0,8.0,9.0,10.0,11.0,12.0,13.0,14.0,15.0,16.0,17.0,18.0,19.0,20.0,21.0,22.0,23.0,24.0,25.0,26.0,27.0,28.0,29.0,30.0,31.0,32.0,33.0,34.0,35.0,36.0,37.0,38.0,39.0,40.0,41.0,42.0,43.0,44.0,45.0,46.0,47.0,48.0,49.0,50.0,51.0,52.0,53.0,54.0,55.0,56.0,57.0,58.0,59.0,60.0,65.0,70.0,75.0,80.0,85.0,90.0,95.0,100.0,105.0,110.0,115.0,120.0,125.0,130.0,135.0,140.0,145.0,150.0,155.0,160.0,165.0,170.0,175.0,180.0,185.0,190.0,195.0,200.0,205.0,210.0,215.0,220.0,225.0,230.0,235.0,240.0,245.0,250.0,255.0,260.0,265.0,270.0,275.0,280.0,285.0,290.0,295.0,300.0,330.0,360.0,390.0,420.0,450.0,480.0,510.0,540.0,570.0,600.0,630.0,660.0,690.0,720.0,750.0,780.0,810.0,840.0,870.0,900.0,930.0,960.0,990.0,1020.0,1050.0,1080.0,1110.0,1140.0,1170.0,1200.0,1230.0,1260.0,1290.0,1320.0,1350.0,1380.0,1410.0,1440.0,1470.0,1500.0,1530.0,1560.0,1590.0,1620.0,1650.0,1680.0,1710.0,1740.0,1770.0,1800.0,1830.0,1860.0,1890.0,1920.0,1950.0,1980.0,2010.0,2040.0,2070.0,2100.0,2130.0,2160.0,2190.0,2220.0,2250.0,2280.0,2310.0,2340.0,2370.0,2400.0,2430.0,2460.0,2490.0,2520.0,2550.0,2580.0,2610.0,2640.0,2670.0,2700.0,2730.0,2760.0,2790.0,2820.0,2850.0,2880.0,2910.0,2940.0,2970.0,3000.0 |
| Removal of PKI inhibition | 2700.0 |
OutputTimes 0.0,0.01,0.02,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9,1.0,1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8,1.9,2.0,2.1,2.2,2.3,2.4,2.5,2.6,2.7,2.8,2.9,3.0,3.1,3.2,3.3,3.4,3.5,3.6,3.7,3.8,3.9,4.0,4.1,4.2,4.3,4.4,4.5,4.6,4.7,4.8,4.9,5.0,6.0,7.0,8.0,9.0,10.0,11.0,12.0,13.0,14.0,15.0,16.0,17.0,18.0,19.0,20.0,21.0,22.0,23.0,24.0,25.0,26.0,27.0,28.0,29.0,30.0,31.0,32.0,33.0,34.0,35.0,36.0,37.0,38.0,39.0,40.0,41.0,42.0,43.0,44.0,45.0,46.0,47.0,48.0,49.0,50.0,51.0,52.0,53.0,54.0,55.0,56.0,57.0,58.0,59.0,60.0,65.0,70.0,75.0,80.0,85.0,90.0,95.0,100.0,105.0,110.0,115.0,120.0,125.0,130.0,135.0,140.0,145.0,150.0,155.0,160.0,165.0,170.0,175.0,180.0,185.0,190.0,195.0,200.0,205.0,210.0,215.0,220.0,225.0,230.0,235.0,240.0,245.0,250.0,255.0,260.0,265.0,270.0,275.0,280.0,285.0,290.0,295.0,300.0,330.0,360.0,390.0,420.0,450.0,480.0,510.0,540.0,570.0,600.0,630.0,660.0,690.0,720.0,750.0,780.0,810.0,840.0,870.0,900.0,930.0,960.0,990.0,1020.0,1050.0,1080.0,1110.0,1140.0,1170.0,1200.0,1230.0,1260.0,1290.0,1320.0,1350.0,1380.0,1410.0,1440.0,1470.0,1500.0,1530.0,1560.0,1590.0,1620.0,1650.0,1680.0,1710.0,1740.0,1770.0,1800.0,1830.0,1860.0,1890.0,1920.0,1950.0,1980.0,2010.0,2040.0,2070.0,2100.0,2130.0,2160.0,2190.0,2220.0,2250.0,2280.0,2310.0,2340.0,2370.0,2400.0,2430.0,2460.0,2490.0,2520.0,2550.0,2580.0,2610.0,2640.0,2670.0,2700.0,2730.0,2760.0,2790.0,2820.0,2850.0,2880.0,2910.0,2940.0,2970.0,3000.0 |
| Removal of PKA act CREB | 2700.0 |
OutputTimes 0.0,0.01,0.02,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9,1.0,1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8,1.9,2.0,2.1,2.2,2.3,2.4,2.5,2.6,2.7,2.8,2.9,3.0,3.1,3.2,3.3,3.4,3.5,3.6,3.7,3.8,3.9,4.0,4.1,4.2,4.3,4.4,4.5,4.6,4.7,4.8,4.9,5.0,6.0,7.0,8.0,9.0,10.0,11.0,12.0,13.0,14.0,15.0,16.0,17.0,18.0,19.0,20.0,21.0,22.0,23.0,24.0,25.0,26.0,27.0,28.0,29.0,30.0,31.0,32.0,33.0,34.0,35.0,36.0,37.0,38.0,39.0,40.0,41.0,42.0,43.0,44.0,45.0,46.0,47.0,48.0,49.0,50.0,51.0,52.0,53.0,54.0,55.0,56.0,57.0,58.0,59.0,60.0,65.0,70.0,75.0,80.0,85.0,90.0,95.0,100.0,105.0,110.0,115.0,120.0,125.0,130.0,135.0,140.0,145.0,150.0,155.0,160.0,165.0,170.0,175.0,180.0,185.0,190.0,195.0,200.0,205.0,210.0,215.0,220.0,225.0,230.0,235.0,240.0,245.0,250.0,255.0,260.0,265.0,270.0,275.0,280.0,285.0,290.0,295.0,300.0,330.0,360.0,390.0,420.0,450.0,480.0,510.0,540.0,570.0,600.0,630.0,660.0,690.0,720.0,750.0,780.0,810.0,840.0,870.0,900.0,930.0,960.0,990.0,1020.0,1050.0,1080.0,1110.0,1140.0,1170.0,1200.0,1230.0,1260.0,1290.0,1320.0,1350.0,1380.0,1410.0,1440.0,1470.0,1500.0,1530.0,1560.0,1590.0,1620.0,1650.0,1680.0,1710.0,1740.0,1770.0,1800.0,1830.0,1860.0,1890.0,1920.0,1950.0,1980.0,2010.0,2040.0,2070.0,2100.0,2130.0,2160.0,2190.0,2220.0,2250.0,2280.0,2310.0,2340.0,2370.0,2400.0,2430.0,2460.0,2490.0,2520.0,2550.0,2580.0,2610.0,2640.0,2670.0,2700.0,2730.0,2760.0,2790.0,2820.0,2850.0,2880.0,2910.0,2940.0,2970.0,3000.0 |
| Removal of bRaf->MEK | 2700.0 |
OutputTimes 0.0,0.01,0.02,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9,1.0,1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8,1.9,2.0,2.1,2.2,2.3,2.4,2.5,2.6,2.7,2.8,2.9,3.0,3.1,3.2,3.3,3.4,3.5,3.6,3.7,3.8,3.9,4.0,4.1,4.2,4.3,4.4,4.5,4.6,4.7,4.8,4.9,5.0,6.0,7.0,8.0,9.0,10.0,11.0,12.0,13.0,14.0,15.0,16.0,17.0,18.0,19.0,20.0,21.0,22.0,23.0,24.0,25.0,26.0,27.0,28.0,29.0,30.0,31.0,32.0,33.0,34.0,35.0,36.0,37.0,38.0,39.0,40.0,41.0,42.0,43.0,44.0,45.0,46.0,47.0,48.0,49.0,50.0,51.0,52.0,53.0,54.0,55.0,56.0,57.0,58.0,59.0,60.0,65.0,70.0,75.0,80.0,85.0,90.0,95.0,100.0,105.0,110.0,115.0,120.0,125.0,130.0,135.0,140.0,145.0,150.0,155.0,160.0,165.0,170.0,175.0,180.0,185.0,190.0,195.0,200.0,205.0,210.0,215.0,220.0,225.0,230.0,235.0,240.0,245.0,250.0,255.0,260.0,265.0,270.0,275.0,280.0,285.0,290.0,295.0,300.0,330.0,360.0,390.0,420.0,450.0,480.0,510.0,540.0,570.0,600.0,630.0,660.0,690.0,720.0,750.0,780.0,810.0,840.0,870.0,900.0,930.0,960.0,990.0,1020.0,1050.0,1080.0,1110.0,1140.0,1170.0,1200.0,1230.0,1260.0,1290.0,1320.0,1350.0,1380.0,1410.0,1440.0,1470.0,1500.0,1530.0,1560.0,1590.0,1620.0,1650.0,1680.0,1710.0,1740.0,1770.0,1800.0,1830.0,1860.0,1890.0,1920.0,1950.0,1980.0,2010.0,2040.0,2070.0,2100.0,2130.0,2160.0,2190.0,2220.0,2250.0,2280.0,2310.0,2340.0,2370.0,2400.0,2430.0,2460.0,2490.0,2520.0,2550.0,2580.0,2610.0,2640.0,2670.0,2700.0,2730.0,2760.0,2790.0,2820.0,2850.0,2880.0,2910.0,2940.0,2970.0,3000.0 |
| Removal MEK->MAPK | 2700.0 |
OutputTimes 0.0,0.01,0.02,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9,1.0,1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8,1.9,2.0,2.1,2.2,2.3,2.4,2.5,2.6,2.7,2.8,2.9,3.0,3.1,3.2,3.3,3.4,3.5,3.6,3.7,3.8,3.9,4.0,4.1,4.2,4.3,4.4,4.5,4.6,4.7,4.8,4.9,5.0,6.0,7.0,8.0,9.0,10.0,11.0,12.0,13.0,14.0,15.0,16.0,17.0,18.0,19.0,20.0,21.0,22.0,23.0,24.0,25.0,26.0,27.0,28.0,29.0,30.0,31.0,32.0,33.0,34.0,35.0,36.0,37.0,38.0,39.0,40.0,41.0,42.0,43.0,44.0,45.0,46.0,47.0,48.0,49.0,50.0,51.0,52.0,53.0,54.0,55.0,56.0,57.0,58.0,59.0,60.0,65.0,70.0,75.0,80.0,85.0,90.0,95.0,100.0,105.0,110.0,115.0,120.0,125.0,130.0,135.0,140.0,145.0,150.0,155.0,160.0,165.0,170.0,175.0,180.0,185.0,190.0,195.0,200.0,205.0,210.0,215.0,220.0,225.0,230.0,235.0,240.0,245.0,250.0,255.0,260.0,265.0,270.0,275.0,280.0,285.0,290.0,295.0,300.0,330.0,360.0,390.0,420.0,450.0,480.0,510.0,540.0,570.0,600.0,630.0,660.0,690.0,720.0,750.0,780.0,810.0,840.0,870.0,900.0,930.0,960.0,990.0,1020.0,1050.0,1080.0,1110.0,1140.0,1170.0,1200.0,1230.0,1260.0,1290.0,1320.0,1350.0,1380.0,1410.0,1440.0,1470.0,1500.0,1530.0,1560.0,1590.0,1620.0,1650.0,1680.0,1710.0,1740.0,1770.0,1800.0,1830.0,1860.0,1890.0,1920.0,1950.0,1980.0,2010.0,2040.0,2070.0,2100.0,2130.0,2160.0,2190.0,2220.0,2250.0,2280.0,2310.0,2340.0,2370.0,2400.0,2430.0,2460.0,2490.0,2520.0,2550.0,2580.0,2610.0,2640.0,2670.0,2700.0,2730.0,2760.0,2790.0,2820.0,2850.0,2880.0,2910.0,2940.0,2970.0,3000.0 |
| Removal of PTP-|MAPK | 2700.0 |
OutputTimes 0.0,0.01,0.02,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9,1.0,1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8,1.9,2.0,2.1,2.2,2.3,2.4,2.5,2.6,2.7,2.8,2.9,3.0,3.1,3.2,3.3,3.4,3.5,3.6,3.7,3.8,3.9,4.0,4.1,4.2,4.3,4.4,4.5,4.6,4.7,4.8,4.9,5.0,6.0,7.0,8.0,9.0,10.0,11.0,12.0,13.0,14.0,15.0,16.0,17.0,18.0,19.0,20.0,21.0,22.0,23.0,24.0,25.0,26.0,27.0,28.0,29.0,30.0,31.0,32.0,33.0,34.0,35.0,36.0,37.0,38.0,39.0,40.0,41.0,42.0,43.0,44.0,45.0,46.0,47.0,48.0,49.0,50.0,51.0,52.0,53.0,54.0,55.0,56.0,57.0,58.0,59.0,60.0,65.0,70.0,75.0,80.0,85.0,90.0,95.0,100.0,105.0,110.0,115.0,120.0,125.0,130.0,135.0,140.0,145.0,150.0,155.0,160.0,165.0,170.0,175.0,180.0,185.0,190.0,195.0,200.0,205.0,210.0,215.0,220.0,225.0,230.0,235.0,240.0,245.0,250.0,255.0,260.0,265.0,270.0,275.0,280.0,285.0,290.0,295.0,300.0,330.0,360.0,390.0,420.0,450.0,480.0,510.0,540.0,570.0,600.0,630.0,660.0,690.0,720.0,750.0,780.0,810.0,840.0,870.0,900.0,930.0,960.0,990.0,1020.0,1050.0,1080.0,1110.0,1140.0,1170.0,1200.0,1230.0,1260.0,1290.0,1320.0,1350.0,1380.0,1410.0,1440.0,1470.0,1500.0,1530.0,1560.0,1590.0,1620.0,1650.0,1680.0,1710.0,1740.0,1770.0,1800.0,1830.0,1860.0,1890.0,1920.0,1950.0,1980.0,2010.0,2040.0,2070.0,2100.0,2130.0,2160.0,2190.0,2220.0,2250.0,2280.0,2310.0,2340.0,2370.0,2400.0,2430.0,2460.0,2490.0,2520.0,2550.0,2580.0,2610.0,2640.0,2670.0,2700.0,2730.0,2760.0,2790.0,2820.0,2850.0,2880.0,2910.0,2940.0,2970.0,3000.0 |
| Removal of PKA import | 2700.0 |
OutputTimes 0.0,0.01,0.02,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9,1.0,1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8,1.9,2.0,2.1,2.2,2.3,2.4,2.5,2.6,2.7,2.8,2.9,3.0,3.1,3.2,3.3,3.4,3.5,3.6,3.7,3.8,3.9,4.0,4.1,4.2,4.3,4.4,4.5,4.6,4.7,4.8,4.9,5.0,6.0,7.0,8.0,9.0,10.0,11.0,12.0,13.0,14.0,15.0,16.0,17.0,18.0,19.0,20.0,21.0,22.0,23.0,24.0,25.0,26.0,27.0,28.0,29.0,30.0,31.0,32.0,33.0,34.0,35.0,36.0,37.0,38.0,39.0,40.0,41.0,42.0,43.0,44.0,45.0,46.0,47.0,48.0,49.0,50.0,51.0,52.0,53.0,54.0,55.0,56.0,57.0,58.0,59.0,60.0,65.0,70.0,75.0,80.0,85.0,90.0,95.0,100.0,105.0,110.0,115.0,120.0,125.0,130.0,135.0,140.0,145.0,150.0,155.0,160.0,165.0,170.0,175.0,180.0,185.0,190.0,195.0,200.0,205.0,210.0,215.0,220.0,225.0,230.0,235.0,240.0,245.0,250.0,255.0,260.0,265.0,270.0,275.0,280.0,285.0,290.0,295.0,300.0,330.0,360.0,390.0,420.0,450.0,480.0,510.0,540.0,570.0,600.0,630.0,660.0,690.0,720.0,750.0,780.0,810.0,840.0,870.0,900.0,930.0,960.0,990.0,1020.0,1050.0,1080.0,1110.0,1140.0,1170.0,1200.0,1230.0,1260.0,1290.0,1320.0,1350.0,1380.0,1410.0,1440.0,1470.0,1500.0,1530.0,1560.0,1590.0,1620.0,1650.0,1680.0,1710.0,1740.0,1770.0,1800.0,1830.0,1860.0,1890.0,1920.0,1950.0,1980.0,2010.0,2040.0,2070.0,2100.0,2130.0,2160.0,2190.0,2220.0,2250.0,2280.0,2310.0,2340.0,2370.0,2400.0,2430.0,2460.0,2490.0,2520.0,2550.0,2580.0,2610.0,2640.0,2670.0,2700.0,2730.0,2760.0,2790.0,2820.0,2850.0,2880.0,2910.0,2940.0,2970.0,3000.0 |
| Removal of MAPK import | 2700.0 |
OutputTimes 0.0,0.01,0.02,0.03,0.04,0.05,0.06,0.07,0.08,0.09,0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9,1.0,1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8,1.9,2.0,2.1,2.2,2.3,2.4,2.5,2.6,2.7,2.8,2.9,3.0,3.1,3.2,3.3,3.4,3.5,3.6,3.7,3.8,3.9,4.0,4.1,4.2,4.3,4.4,4.5,4.6,4.7,4.8,4.9,5.0,6.0,7.0,8.0,9.0,10.0,11.0,12.0,13.0,14.0,15.0,16.0,17.0,18.0,19.0,20.0,21.0,22.0,23.0,24.0,25.0,26.0,27.0,28.0,29.0,30.0,31.0,32.0,33.0,34.0,35.0,36.0,37.0,38.0,39.0,40.0,41.0,42.0,43.0,44.0,45.0,46.0,47.0,48.0,49.0,50.0,51.0,52.0,53.0,54.0,55.0,56.0,57.0,58.0,59.0,60.0,65.0,70.0,75.0,80.0,85.0,90.0,95.0,100.0,105.0,110.0,115.0,120.0,125.0,130.0,135.0,140.0,145.0,150.0,155.0,160.0,165.0,170.0,175.0,180.0,185.0,190.0,195.0,200.0,205.0,210.0,215.0,220.0,225.0,230.0,235.0,240.0,245.0,250.0,255.0,260.0,265.0,270.0,275.0,280.0,285.0,290.0,295.0,300.0,330.0,360.0,390.0,420.0,450.0,480.0,510.0,540.0,570.0,600.0,630.0,660.0,690.0,720.0,750.0,780.0,810.0,840.0,870.0,900.0,930.0,960.0,990.0,1020.0,1050.0,1080.0,1110.0,1140.0,1170.0,1200.0,1230.0,1260.0,1290.0,1320.0,1350.0,1380.0,1410.0,1440.0,1470.0,1500.0,1530.0,1560.0,1590.0,1620.0,1650.0,1680.0,1710.0,1740.0,1770.0,1800.0,1830.0,1860.0,1890.0,1920.0,1950.0,1980.0,2010.0,2040.0,2070.0,2100.0,2130.0,2160.0,2190.0,2220.0,2250.0,2280.0,2310.0,2340.0,2370.0,2400.0,2430.0,2460.0,2490.0,2520.0,2550.0,2580.0,2610.0,2640.0,2670.0,2700.0,2730.0,2760.0,2790.0,2820.0,2850.0,2880.0,2910.0,2940.0,2970.0,3000.0 |
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Assignments
| Name | Variable | Assignment Function Expression |
|---|
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| Name | Trigger Type | Variable Assignment |
|---|
Geometry non-spatial1212631236
(Origin: 0.0, 0.0, 0.0; Extent: 10.0, 10.0, 10.0 [um])
| Dimension | Type | Subdomain | Adjacent Subvolumes | Size | Mapped Compartment |
|---|---|---|---|---|---|
| Compartmental | Compartment | nuclear membrane |
Events
| Name | Variable | Rate Expression |
|---|
Global Parameters
| Name | Expression |
|---|---|
| kimportPKI | 0.001[um.s-1] |
| Km_Rap1BRaf | 0.5[uM] |
| kcat_Rap1Braf | 0.105[s-1] |
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Downloads
| Model Format | Model Downloads |
|---|---|
| Virtual Cell Markup Language | VCML File |
| PDF Report | Report |
| COMBINE Archive | OMEX File |
| SEDML | SEDML File |
| File Format | Application Downloads |
| BNGL | Compart.bngl |
| SBML | Compart.sbml |
| Matlab | Compart.m |
| NFSim XML | Compart.xml |