ModelBricks - Model Print Page

Name - Falkenberg_GTPases_Rac_betaCell

BioModel ID - 60113862

Reaction Diagram

Physiology

Universal ID's	Text Annotations

Reactions See in Dashboard
Reaction	Name Structure	Kinetics	Depiction
GDIuuco_Rac1cgTpGDIuuco+Rac1cgTp	R20 Cytoplasm	GeneralKinetics	GDIuuco_Rac1cgTpGDIuuco+Rac1cgTp
		reaction rate (J): ((koffT_3d_R1 * GDIuuco_Rac1cgTp) - (konT_3d_R1 * GDIuuco * Rac1cgTp))[uM.s-1]
Rac1cgDpRac1ggDp	R14 Granules	GeneralKinetics	Rac1cgDpRac1ggDp
		reaction rate (J): (sbmlRateFactor * ((rateParam17 * Rac1cgDp) - (rateParam18 * Rac1ggDp * Rac1ggDp_ConcFactor)) / KMOLE)[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] user defined (Rac1ggDp_ConcFactor): 1.6611295681063123E-6[1000] user defined (sbmlRateFactor): 9.999999999999999E14[1.0E-15]
Rac1mgDpRac1mgTp	R15 Membrane	GeneralKinetics	Rac1mgDpRac1mgTp
		reaction rate (J): (sbmlRateFactor * ((rateParam21 * Rac1mgDp * Rac1mgDp_ConcFactor) - (rateParam22 * Rac1mgTp * Rac1mgTp_ConcFactor)) / KMOLE)[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] user defined (Rac1mgDp_ConcFactor): 1.6611295681063123E-6[1000] user defined (Rac1mgTp_ConcFactor): 1.6611295681063123E-6[1000] user defined (sbmlRateFactor): 9.999999999999999E14[1.0E-15]
Rac1cgDpRac1mgDp	R11 Membrane	GeneralKinetics	Rac1cgDpRac1mgDp
		reaction rate (J): (sbmlRateFactor * ((rateParam13 * Rac1cgDp) - (rateParam14 * Rac1mgDp * Rac1mgDp_ConcFactor)) / KMOLE)[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] user defined (Rac1mgDp_ConcFactor): 1.6611295681063123E-6[1000] user defined (sbmlRateFactor): 9.999999999999999E14[1.0E-15]
Rac1mgTpRac1cgTp	R13 Membrane	GeneralKinetics	Rac1mgTpRac1cgTp
		reaction rate (J): (sbmlRateFactor * ((rateParam16 * Rac1mgTp * Rac1mgTp_ConcFactor) - (rateParam15 * Rac1cgTp)) / KMOLE)[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] user defined (Rac1mgTp_ConcFactor): 1.6611295681063123E-6[1000] user defined (sbmlRateFactor): 9.999999999999999E14[1.0E-15]
GDIpuco+Rac1cgDpGDIpuco_Rac1cgDp	R21 Cytoplasm	GeneralKinetics	GDIpuco+Rac1cgDpGDIpuco_Rac1cgDp
		reaction rate (J): ((rateParam27 * GDIpuco * Rac1cgDp) - (koffD_3d_R1 * GDIpuco_Rac1cgDp))[uM.s-1]
Rac1ggDpRac1ggTp	R31 Granules	GeneralKinetics	Rac1ggDpRac1ggTp
		reaction rate (J): (sbmlRateFactor * ((rateParam23 * Rac1ggDp * Rac1ggDp_ConcFactor) - (rateParam24 * Rac1ggTp * Rac1ggTp_ConcFactor)) / KMOLE)[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] user defined (Rac1ggDp_ConcFactor): 1.6611295681063123E-6[1000] user defined (Rac1ggTp_ConcFactor): 1.6611295681063123E-6[1000] user defined (sbmlRateFactor): 9.999999999999999E14[1.0E-15]
GDIpuco+Rac1cgTpGDIpuco_Rac1cgTp	R35 Cytoplasm	GeneralKinetics	GDIpuco+Rac1cgTpGDIpuco_Rac1cgTp
		reaction rate (J): ((rateParam28 * GDIpuco * Rac1cgTp) - (koffT_3d_R1 * GDIpuco_Rac1cgTp))[uM.s-1]
Rac1cgDpRac1cgTp	R17 Cytoplasm	GeneralKinetics	Rac1cgDpRac1cgTp
		reaction rate (J): ((gef_Cyt_R1 * Rac1cgDp) - (gap_Cyt_R1 * Rac1cgTp))[uM.s-1]
GDIuuco+Rac1cgDpGDIuuco_Rac1cgDp	R18 Cytoplasm	GeneralKinetics	GDIuuco+Rac1cgDpGDIuuco_Rac1cgDp
		reaction rate (J): ((konD_3d_R1 * GDIuuco * Rac1cgDp) - (koffD_3d_R1 * GDIuuco_Rac1cgDp))[uM.s-1]
PLDmaTrashm	R41 Membrane	GeneralKinetics	PLDmaTrashm
		reaction rate (J): (sbmlRateFactor * rateParam3 * PLDma * PLDma_ConcFactor / KMOLE)[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] user defined (PLDma_ConcFactor): 1.6611295681063123E-6[1000] user defined (sbmlRateFactor): 9.999999999999999E14[1.0E-15]
PLDgiPLDci	R1 Granules	GeneralKinetics	PLDgiPLDci
		reaction rate (J): (sbmlRateFactor * rateParam1 * PLDgi * PLDgi_ConcFactor / KMOLE)[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] user defined (PLDgi_ConcFactor): 1.6611295681063123E-6[1000] user defined (sbmlRateFactor): 9.999999999999999E14[1.0E-15]
GDIuucoGDIuumo	R2 Membrane	GeneralKinetics	GDIuucoGDIuumo
		reaction rate (J): (sbmlRateFactor * ((rateParam5 * GDIuuco) - (rateParam4 * GDIuumo * GDIuumo_ConcFactor)) / KMOLE)[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] user defined (GDIuumo_ConcFactor): 1.6611295681063123E-6[1000] user defined (sbmlRateFactor): 9.999999999999999E14[1.0E-15]
GDIuucoGDIuugo	R4 Granules	GeneralKinetics	GDIuucoGDIuugo
		reaction rate (J): (sbmlRateFactor * ((rateParam9 * GDIuuco) - (rateParam8 * GDIuugo * GDIuugo_ConcFactor)) / KMOLE)[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] user defined (GDIuugo_ConcFactor): 1.6611295681063123E-6[1000] user defined (sbmlRateFactor): 9.999999999999999E14[1.0E-15]
GDIpucoGDIpugo	R5 Granules	GeneralKinetics	GDIpucoGDIpugo
		reaction rate (J): (sbmlRateFactor * ((rateParam9 * GDIpuco) - (rateParam8 * GDIpugo * GDIpugo_ConcFactor)) / KMOLE)[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] user defined (GDIpugo_ConcFactor): 1.6611295681063123E-6[1000] user defined (sbmlRateFactor): 9.999999999999999E14[1.0E-15]
pakucpakpc	R6 Cytoplasm	GeneralKinetics	pakucpakpc
		reaction rate (J): ((P_pak * pakuc) - (dP_pak * pakpc))[uM.s-1]
GDIuucoGDIpuco	R7 Cytoplasm	GeneralKinetics	GDIuucoGDIpuco
		reaction rate (J): ((P_G_s * GDIuuco) - (dP_G_s * GDIpuco))[uM.s-1]
NonGlucLcGlucLc	R9 Cytoplasm	GeneralKinetics	NonGlucLcGlucLc
		reaction rate (J): ((rateParam12 * NonGlucLc) - (koffGluc * GlucLc))[uM.s-1]
GDIpucoGDIpumo	R3 Membrane	GeneralKinetics	GDIpucoGDIpumo
		reaction rate (J): (sbmlRateFactor * ((rateParam5 * GDIpuco) - (rateParam4 * GDIpumo * GDIpumo_ConcFactor)) / KMOLE)[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] user defined (GDIpumo_ConcFactor): 1.6611295681063123E-6[1000] user defined (sbmlRateFactor): 9.999999999999999E14[1.0E-15]
Rac1cgTpRac1ggTp	R30 Granules	GeneralKinetics	Rac1cgTpRac1ggTp
		reaction rate (J): (sbmlRateFactor * ((rateParam19 * Rac1cgTp) - (rateParam20 * Rac1ggTp * Rac1ggTp_ConcFactor)) / KMOLE)[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] user defined (Rac1ggTp_ConcFactor): 1.6611295681063123E-6[1000] user defined (sbmlRateFactor): 9.999999999999999E14[1.0E-15]
PLDmiTrashm	R36 Membrane	GeneralKinetics	PLDmiTrashm
		reaction rate (J): (sbmlRateFactor * rateParam3 * PLDmi * PLDmi_ConcFactor / KMOLE)[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] user defined (PLDmi_ConcFactor): 1.6611295681063123E-6[1000] user defined (sbmlRateFactor): 9.999999999999999E14[1.0E-15]
PLDciPLDmi	R22 Membrane	GeneralKinetics	PLDciPLDmi
		reaction rate (J): (sbmlRateFactor * rateParam2 * PLDci / KMOLE)[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] user defined (sbmlRateFactor): 9.999999999999999E14[1.0E-15]
PLDmiPLDma	R37 Membrane	GeneralKinetics	PLDmiPLDma
		reaction rate (J): (sbmlRateFactor * ((actPLD * PLDmi * PLDmi_ConcFactor) - (inacPLD * PLDma * PLDma_ConcFactor)) / KMOLE)[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] user defined (PLDma_ConcFactor): 1.6611295681063123E-6[1000] user defined (PLDmi_ConcFactor): 1.6611295681063123E-6[1000] user defined (sbmlRateFactor): 9.999999999999999E14[1.0E-15]

Structures See in Dashboard
Name	Type Electrical (Membrane Polarity)
Extracellular	Compartment (+) (-)

Cytoplasm	Compartment (+) (-)

inGranules	Compartment (+) (-)

Granules	Membrane N/A

Membrane	Membrane N/A

Species See in Dashboard
Name	Structure	BioNetGen Definition
GDIuuco_Rac1cgTp	Cytoplasm

GDIuumo_Rac1mgDp	Membrane

GDIuumo_Rac1mgTp	Membrane

Rac1mgDp	Membrane

Rac1mgTp	Membrane

pakuc	Cytoplasm

NonGlucLc	Cytoplasm

glucc	Cytoplasm

GlucLc	Cytoplasm

PLDgi	Granules

Trashm	Membrane

PLDci	Cytoplasm

GDIuumo	Membrane

GDIpumo	Membrane

GDIuugo	Granules

GDIpugo	Granules

pakpc	Cytoplasm

Rac1cgTp	Cytoplasm

Rac1ggDp	Granules

GDIpuco_Rac1cgDp	Cytoplasm

PLDmi	Membrane

Rac1ggTp	Granules

GDIpuco_Rac1cgTp	Cytoplasm

PLDma	Membrane

GDIuuco	Cytoplasm

GDIpuco	Cytoplasm

Rac1cgDp	Cytoplasm

GDIuuco_Rac1cgDp	Cytoplasm

Molecules See in Dashboard
Name	Text Annotations	BioNetGen Definition

Observables See in Dashboard
Name	Type Count	BioNetGen Definition

Applications

Applications See in Dashboard
Name	Math Type	Annotation
psGDIfactor_R1=0.1; find SS with no gluc	Deterministic (ODE) Compartmental	(copied from C:\Documents and Settings\cfalkenberg\.vcell\BioNetGen\vcell_bng_1222\vcell_bng_1222_Compartmental)
psGDIfactor_R1=0.1+change konM+coefonGR; transient studies	Deterministic (ODE) Compartmental	(copied from psGDIfactor_R1=0.1; transient studies) (copied from psGDIfactor_R1=0; transient studies) (copied from C:\Documents and Settings\cfalkenberg\.vcell\BioNetGen\vcell_bng_1222\vcell_bng_1222_Compartmental)

Application - psGDIfactor_R1=0.1; find SS with no gluc

Specifications(Species) - psGDIfactor_R1=0.1; find SS with no gluc See in Dashboard
Species	Initial Condition	Diffusion Constant
GDIuuco_Rac1cgTp	0.0 [uM]	0.0 [um2/s]
pakuc	0.5 [uM]	0.0 [um2/s]
NonGlucLc	1.0 [uM]	0.0 [um2/s]
glucc	0.0 [uM]	0.0 [um2/s]
GlucLc	0.0 [uM]	0.0 [um2/s]
PLDci	0.0 [uM]	0.0 [um2/s]
pakpc	0.0 [uM]	0.0 [um2/s]
Rac1cgTp	0.0 [uM]	0.0 [um2/s]
GDIpuco_Rac1cgDp	0.0 [uM]	0.0 [um2/s]
GDIpuco_Rac1cgTp	0.0 [uM]	0.0 [um2/s]
GDIuuco	0.07 [uM]	0.0 [um2/s]
GDIpuco	0.06 [uM]	0.0 [um2/s]
Rac1cgDp	0.0427 [uM]	0.0 [um2/s]
GDIuuco_Rac1cgDp	0.11 [uM]	0.0 [um2/s]
PLDgi	2.7777777777777777 [uM]	0.0 [um2/s]
GDIuugo	0.0 [uM]	0.0 [um2/s]
GDIpugo	0.0 [uM]	0.0 [um2/s]
Rac1ggDp	0.0 [uM]	0.0 [um2/s]
Rac1ggTp	0.0 [uM]	0.0 [um2/s]
GDIuumo_Rac1mgDp	0.0 [uM]	0.0 [um2/s]
GDIuumo_Rac1mgTp	0.0 [uM]	0.0 [um2/s]
Rac1mgDp	0.0 [uM]	0.0 [um2/s]
Rac1mgTp	0.0 [uM]	0.0 [um2/s]
Trashm	601999.9999999999 [uM]	0.0 [um2/s]
GDIuumo	0.0 [uM]	0.0 [um2/s]
GDIpumo	0.0 [uM]	0.0 [um2/s]
PLDmi	0.0 [uM]	0.0 [um2/s]
PLDma	0.0 [uM]	0.0 [um2/s]

Specifications(Reaction) - psGDIfactor_R1=0.1; find SS with no gluc See in Dashboard
Name	Reaction Mapping
R20	included
R14	included
R15	included
R11	included
R13	included
R21	included
R31	included
R35	included
R17	included
R18	included
R41	included
R1	included
R2	included
R4	included
R5	included
R6	included
R7	included
R9	included
R3	included
R30	included
R36	included
R22	included
R37	included

Simulations - psGDIfactor_R1=0.1; find SS with no gluc See in Dashboard
Name	End Time	Output Options
find SS	5000.0 [s]	KeepEvery 500 KeepAtMost 1000

Events - psGDIfactor_R1=0.1; find SS with no gluc See in Dashboard
Name	Trigger Type	Variable Assignment
event0	on condition: (t > tgluc)	glucc --> 20000.0, actPak --> (0.116 + (0.116 * changePsGDI)), gef_R1 --> (gef0_R1 + (((gef0_R1 * coef_gef) - gef0_R1) * change_gef_only))

Geometry Compartmental1146174258 See in Dashboard
(Origin: 0.0, 0.0, 0.0; Extent: 10.0, 10.0, 10.0[um])
Dimension	Type	Subdomain	Adjacent Subvolumes	Size	Mapped Compartment
	Compartmental	Compartment			Membrane

Application - psGDIfactor_R1=0.1+change konM+coefonGR; transient studies

Specifications(Species) - psGDIfactor_R1=0.1+change konM+coefonGR; transient studies See in Dashboard
Species	Initial Condition	Diffusion Constant
GDIuuco_Rac1cgTp	1.6563957705568633E-4 [uM]	0.0 [um2/s]
pakuc	0.11240310077519382 [uM]	0.0 [um2/s]
NonGlucLc	1.0 [uM]	0.0 [um2/s]
glucc	0.0 [uM]	0.0 [um2/s]
GlucLc	0.0 [uM]	0.0 [um2/s]
PLDci	0.0 [uM]	0.0 [um2/s]
pakpc	0.38759689922480617 [uM]	0.0 [um2/s]
Rac1cgTp	3.622850570650371E-7 [uM]	0.0 [um2/s]
GDIpuco_Rac1cgDp	0.011582451335819324 [uM]	0.0 [um2/s]
GDIpuco_Rac1cgTp	1.9214186222063993E-5 [uM]	0.0 [um2/s]
GDIuuco	0.05943702212607566 [uM]	0.0 [um2/s]
GDIpuco	0.06894692985331065 [uM]	0.0 [um2/s]
Rac1cgDp	2.183880698389099E-4 [uM]	0.0 [um2/s]
GDIuuco_Rac1cgDp	0.09984874292151663 [uM]	0.0 [um2/s]
PLDgi	2.7777777777777777 [uM]	0.0 [um2/s]
GDIuugo	0.0 [uM]	0.0 [um2/s]
GDIpugo	0.0 [uM]	0.0 [um2/s]
Rac1ggDp	4.770672010383799 [uM]	0.0 [um2/s]
Rac1ggTp	0.0031608535148760723 [uM]	0.0 [um2/s]
GDIuumo_Rac1mgDp	0.0 [uM]	0.0 [um2/s]
GDIuumo_Rac1mgTp	0.0 [uM]	0.0 [um2/s]
Rac1mgDp	4.554384740079095 [uM]	0.0 [um2/s]
Rac1mgTp	2.9446676851097253 [uM]	0.0 [um2/s]
Trashm	601999.9999999999 [uM]	0.0 [um2/s]
GDIuumo	0.0 [uM]	0.0 [um2/s]
GDIpumo	0.0 [uM]	0.0 [um2/s]
PLDmi	0.0 [uM]	0.0 [um2/s]
PLDma	0.0 [uM]	0.0 [um2/s]

Specifications(Reaction) - psGDIfactor_R1=0.1+change konM+coefonGR; transient studies See in Dashboard
Name	Reaction Mapping
R20	included
R14	included
R15	included
R11	included
R13	included
R21	included
R31	included
R35	included
R17	included
R18	included
R41	included
R1	included
R2	included
R4	included
R5	included
R6	included
R7	included
R9	included
R3	included
R30	included
R36	included
R22	included
R37	included

Simulations - psGDIfactor_R1=0.1+change konM+coefonGR; transient studies See in Dashboard
Name	End Time	Output Options
effect of ps-gdi only	4000.0 [s]	KeepEvery 500 KeepAtMost 1000
effect of increase konM over t; coef on Gr=0; coef pld0=1.5	4000.0 [s]	KeepEvery 500 KeepAtMost 1000
effect of increase konM and konGr: coef on Gr=1.5; coef pld0=[1,1.5,2]	4000.0 [s]	KeepEvery 500 KeepAtMost 1000
effect of increase konM and konGr: coef on Gr=2; coef pld0=[1,1.5,2]	4000.0 [s]	KeepEvery 500 KeepAtMost 1000

Events - psGDIfactor_R1=0.1+change konM+coefonGR; transient studies See in Dashboard
Name	Trigger Type	Variable Assignment
event0	on condition: (t > tgluc)	glucc --> 20000.0, actPak --> (0.116 + (0.116 * changePsGDI)), gef_R1 --> (gef0_R1 + (((gef0_R1 * coef_gef) - gef0_R1) * change_gef_only))

Geometry Compartmental1146174258 See in Dashboard
(Origin: 0.0, 0.0, 0.0; Extent: 10.0, 10.0, 10.0[um])
Dimension	Type	Subdomain	Adjacent Subvolumes	Size	Mapped Compartment
	Compartmental	Compartment			Membrane

Global Parameters

Global Parameters See in Dashboard
Name	Expression
SfRAVolNIH3T3	0.524[tbd]

SfRAVol	0.587[tbd]

toexport2	1.0E-12[tbd]

FR	1.0[tbd]

fusRate	((1.67E-5 * (t >= (600.0 + tgluc))) + (2.779166666666666E-7 * (t > (60.0 + tgluc)) * (t < (300.0 + tgluc)) * ( - (60.0 + tgluc) + t)) + ((t >= (300.0 + tgluc)) * (t < (600.0 + tgluc)) * (6.67E-5 - (1.6666666666666668E-7 * ( - (300.0 + tgluc) + t)))))[tbd]

coef_on_Gr	1.0[tbd]

actPLD	0.1[tbd]

inacPLD	0.1[tbd]

actPak	0.116[tbd]

coefP_G_s	0.02[tbd]

changePsGDI	0.0[tbd]

gluc0	glucc[tbd]

KDM_G	10.0[tbd]

koffM_G	1.0[tbd]

KDMp_G	0.1[tbd]

koffMp_G	0.1[tbd]

KDGr_G	10.0[tbd]

koffGr_G	1.0[tbd]

KDGrp_G	0.1[tbd]

koffGrp_G	0.1[tbd]

kon_Pak_G	1.0[tbd]

koff_Pak_G	1.0[tbd]

alphaPak	1.0[tbd]

KD_pak_C2	2.9[tbd]

KD_pak_R1	0.7[tbd]

koffPak_C2	1.0[tbd]

koffPak_R1	1.0[tbd]

gtpm_C2	1.0[tbd]

gtpm_R1	1.0[tbd]

dP_pak	0.1[tbd]

P_R1	0.0[tbd]

dP_R1	0.0[tbd]

pld0	(changekonM * PLDma / (0.1 + PLDma))[tbd]

koffMD_R1	0.1496[tbd]

koffMT_R1	0.011[tbd]

koffGrD_R1	0.1496[tbd]

koffGrT_R1	0.011[tbd]

gef_R1	gef0_R1[tbd]

gef_Cyt_R1	0.0[tbd]

gef_Gr_R1	0.01[tbd]

KDD_2d_R1	1.0[tbd]

KDT_2d_R1	1.0[tbd]

koff1_2d_R1	0.0[tbd]

phospFactor2_R1	1.0[tbd]

koff1P_2d_R1	0.0[tbd]

geomFac25_R1	1.0[tbd]

koff1_25d_R1	0.0[tbd]

phospFactor25_R1	1.0[tbd]

koff1P_25d_R1	0.0[tbd]

alpha_R1	1.0[tbd]

koff1_3d_R1	0.044[tbd]

phospFactor3_R1	1.0[tbd]

koff1P_3d_R1	0.044[tbd]

koffMD_gG_R1	0.1496[tbd]

koffMT_gG_R1	0.1496[tbd]

konM_gG_R1	0.0[tbd]

konE_R1	0.1[tbd]

koffE_R1	0.1[tbd]

pGdifactor_R1	0.1[tbd]

psGdifactor_R1	0.1[tbd]

konGluc	1.0E-7[tbd]

koffGluc	0.001[tbd]

Vol2Sfc	(1.0 / SfRAVol)[tbd]

SfcGr	4.230317273795534[tbd]

VolGr	0.23501762632197415[tbd]

VolCyt2SfcGr	(1.0 / SfcGr)[tbd]

toexportM	0.0019083969465648854[tbd]

toexport1	(0.001 * Vol2Sfc)[tbd]

toexport1gr	(0.001 * VolCyt2SfcGr)[tbd]

pmp	(toexportM * toexport2)[tbd]

pmp0	toexport2[tbd]

pmpGr	(toexportM * toexport2)[tbd]

P_G_s	(actPak * coefP_G_s)[tbd]

dP_G_s	(0.1 * coefP_G_s)[tbd]

konM_G	0.0[tbd]

konMp_G	0.0[tbd]

konGr_G	0.0[tbd]

konGrp_G	0.0[tbd]

konPak_C2	(koffPak_C2 / KD_pak_C2)[tbd]

konPak_R1	(koffPak_R1 / KD_pak_R1)[tbd]

P_pak	(alphaPak * gtpm_C2 / KD_pak_C2)[tbd]

konM_R1	(2.84 * (1.0 + (coef_pld0 * pld0)))[tbd]

konGr_R1	(2.84 * (1.0 + (coef_on_Gr * pld0)))[tbd]

gap_R1	(1.5455950540958268 * gef0_R1)[tbd]

gap_Cyt_R1	(4.0 * gap_R1)[tbd]

gap_Gr_R1	gap_R1[tbd]

koffD_2d_R1	koff1_2d_R1[tbd]

koffT_2d_R1	koff1_2d_R1[tbd]

konD_2d_R1	(koffD_2d_R1 / KDD_2d_R1)[tbd]

konT_2d_R1	(koffT_2d_R1 / KDT_2d_R1)[tbd]

KDDP_2d_R1	(KDD_2d_R1 / phospFactor2_R1)[tbd]

KDTP_2d_R1	(KDD_2d_R1 / phospFactor2_R1)[tbd]

koffDP_2d_R1	koff1P_2d_R1[tbd]

koffTP_2d_R1	koff1P_2d_R1[tbd]

konDP_2d_R1	(koffDP_2d_R1 / KDDP_2d_R1)[tbd]

konTP_2d_R1	(koffTP_2d_R1 / KDTP_2d_R1)[tbd]

KDD_25d_R1	(5.2E-4 / geomFac25_R1)[tbd]

KDT_25d_R1	(5.2E-4 / geomFac25_R1)[tbd]

koffD_25d_R1	koff1_25d_R1[tbd]

koffT_25d_R1	koff1_25d_R1[tbd]

konD_25d_R1	(koffD_25d_R1 / KDD_25d_R1)[tbd]

konT_25d_R1	(koffT_25d_R1 / KDT_25d_R1)[tbd]

KDDP_25d_R1	(KDD_25d_R1 / phospFactor25_R1)[tbd]

KDTP_25d_R1	(KDD_25d_R1 / phospFactor25_R1)[tbd]

koffDP_25d_R1	koff1P_25d_R1[tbd]

koffTP_25d_R1	koff1P_25d_R1[tbd]

konDP_25d_R1	(koffDP_25d_R1 / KDDP_25d_R1)[tbd]

konTP_25d_R1	(koffTP_25d_R1 / KDTP_25d_R1)[tbd]

KDD_3d_R1	(1.3E-4 * alpha_R1)[tbd]

KDT_3d_R1	(1.3E-4 * alpha_R1)[tbd]

koffD_3d_R1	koff1_3d_R1[tbd]

koffT_3d_R1	koff1_3d_R1[tbd]

konD_3d_R1	(koffD_3d_R1 / KDD_3d_R1)[tbd]

konT_3d_R1	(koffT_3d_R1 / KDT_3d_R1)[tbd]

KDDP_3d_R1	(KDD_3d_R1 / phospFactor3_R1)[tbd]

KDTP_3d_R1	(KDD_3d_R1 / phospFactor3_R1)[tbd]

koffDP_3d_R1	koff1P_3d_R1[tbd]

koffTP_3d_R1	koff1P_3d_R1[tbd]

konDP_3d_R1	(koffDP_3d_R1 / KDDP_3d_R1)[tbd]

konTP_3d_R1	(koffTP_3d_R1 / KDTP_3d_R1)[tbd]

ppGdifactor_R1	(pGdifactor_R1 * psGdifactor_R1)[tbd]

InitialConc1	0.0[tbd]

InitialConc2	0.0[tbd]

InitialConc3	0.0[tbd]

InitialConc4	0.0[tbd]

InitialConc5	(pmpGr / pmp0)[tbd]

rateParam1	(fusRate * pmp0)[tbd]

rateParam2	(1.0E10 * fusRate * pmpGr)[tbd]

rateParam3	(7.2 * fusRate * pmp0)[tbd]

rateParam4	(koffM_G * pmp0)[tbd]

rateParam5	(konM_G * pmp)[tbd]

rateParam6	(koffMp_G * pmp0)[tbd]

rateParam7	(konMp_G * pmp)[tbd]

rateParam8	(koffGr_G * pmp0)[tbd]

rateParam9	(konGr_G * pmp)[tbd]

rateParam10	(koffGrp_G * pmp0)[tbd]

rateParam11	(konGrp_G * pmp)[tbd]

rateParam12	(konGluc * gluc0)[tbd]

rateParam13	(konM_R1 * pmp)[tbd]

rateParam14	(koffMD_R1 * pmp0)[tbd]

rateParam15	(konM_R1 * pmp)[tbd]

rateParam16	(koffMT_R1 * pmp0)[tbd]

rateParam17	(konGr_R1 * pmpGr)[tbd]

rateParam18	(koffGrD_R1 * pmp0)[tbd]

rateParam19	(konGr_R1 * pmpGr)[tbd]

rateParam20	(koffGrT_R1 * pmp0)[tbd]

rateParam21	(gef_R1 * pmp0)[tbd]

rateParam22	(gap_R1 * pmp0)[tbd]

rateParam23	(gef_Gr_R1 * pmp0)[tbd]

rateParam24	(gap_Gr_R1 * pmp0)[tbd]

rateParam25	(pGdifactor_R1 * konD_3d_R1)[tbd]

rateParam26	(pGdifactor_R1 * konT_3d_R1)[tbd]

rateParam27	(psGdifactor_R1 * konD_3d_R1)[tbd]

rateParam28	(psGdifactor_R1 * konT_3d_R1)[tbd]

Group_nonG	NonGlucLc[tbd]

Group_glucL	GlucLc[tbd]

VC_SpConcFactor_1000_0	1.6611295681063123E-6 [1000]

Group_Rac1	(Rac1cgDp + GDIuuco_Rac1cgDp + GDIuuco_Rac1cgTp + (GDIuumo_Rac1mgDp * VC_SpConcFactor_1000_0) + (GDIuumo_Rac1mgTp * VC_SpConcFactor_1000_0) + (Rac1mgDp * VC_SpConcFactor_1000_0) + (Rac1mgTp * VC_SpConcFactor_1000_0) + Rac1cgTp + (Rac1ggDp * VC_SpConcFactor_1000_0) + GDIpuco_Rac1cgDp + (Rac1ggTp * VC_SpConcFactor_1000_0) + GDIpuco_Rac1cgTp)[tbd]

Group_GDI	(GDIuuco + GDIpuco + GDIuuco_Rac1cgDp + GDIuuco_Rac1cgTp + (GDIuumo_Rac1mgDp * VC_SpConcFactor_1000_0) + (GDIuumo_Rac1mgTp * VC_SpConcFactor_1000_0) + (GDIuumo * VC_SpConcFactor_1000_0) + (GDIpumo * VC_SpConcFactor_1000_0) + (GDIuugo * VC_SpConcFactor_1000_0) + (GDIpugo * VC_SpConcFactor_1000_0) + GDIpuco_Rac1cgDp + GDIpuco_Rac1cgTp)[tbd]

Group_pak	(pakuc + pakpc)[tbd]

Group_tot_Rac1_M	(((GDIuumo_Rac1mgDp * VC_SpConcFactor_1000_0) + (GDIuumo_Rac1mgTp * VC_SpConcFactor_1000_0) + (Rac1mgDp * VC_SpConcFactor_1000_0) + (Rac1mgTp * VC_SpConcFactor_1000_0)) / VC_SpConcFactor_1000_0)[tbd]

Group_tot_Rac1_G	(((Rac1ggDp * VC_SpConcFactor_1000_0) + (Rac1ggTp * VC_SpConcFactor_1000_0)) / VC_SpConcFactor_1000_0)[tbd]

Group_tot_Rac1_C	(Rac1cgDp + GDIuuco_Rac1cgDp + GDIuuco_Rac1cgTp + Rac1cgTp + GDIpuco_Rac1cgDp + GDIpuco_Rac1cgTp)[tbd]

Group_Rac1_Mfree	(((Rac1mgDp * VC_SpConcFactor_1000_0) + (Rac1mgTp * VC_SpConcFactor_1000_0)) / VC_SpConcFactor_1000_0)[tbd]

Group_Rac1_GDP_m	(((GDIuumo_Rac1mgDp * VC_SpConcFactor_1000_0) + (Rac1mgDp * VC_SpConcFactor_1000_0)) / VC_SpConcFactor_1000_0)[tbd]

Group_Rac1_GTP_m	(((GDIuumo_Rac1mgTp * VC_SpConcFactor_1000_0) + (Rac1mgTp * VC_SpConcFactor_1000_0)) / VC_SpConcFactor_1000_0)[tbd]

Group_Rac1_GDP_c	(Rac1cgDp + GDIuuco_Rac1cgDp + GDIpuco_Rac1cgDp)[tbd]

Group_Rac1_GTP_c	(GDIuuco_Rac1cgTp + Rac1cgTp + GDIpuco_Rac1cgTp)[tbd]

Group_Rac1_c_g	(GDIuuco_Rac1cgDp + GDIpuco_Rac1cgDp)[tbd]

Group_GDI_c	(GDIuuco + GDIpuco + GDIuuco_Rac1cgDp + GDIuuco_Rac1cgTp + GDIpuco_Rac1cgDp + GDIpuco_Rac1cgTp)[tbd]

Group_GDI_m	(((GDIuumo_Rac1mgDp * VC_SpConcFactor_1000_0) + (GDIuumo_Rac1mgTp * VC_SpConcFactor_1000_0) + (GDIuumo * VC_SpConcFactor_1000_0) + (GDIpumo * VC_SpConcFactor_1000_0)) / VC_SpConcFactor_1000_0)[tbd]

Group_GDI_g	(((GDIuugo * VC_SpConcFactor_1000_0) + (GDIpugo * VC_SpConcFactor_1000_0)) / VC_SpConcFactor_1000_0)[tbd]

Group_GDI_mb_g	(((GDIuumo_Rac1mgDp * VC_SpConcFactor_1000_0) + (GDIuumo_Rac1mgTp * VC_SpConcFactor_1000_0)) / VC_SpConcFactor_1000_0)[tbd]

Group_GDI_mf	(((GDIuumo * VC_SpConcFactor_1000_0) + (GDIpumo * VC_SpConcFactor_1000_0)) / VC_SpConcFactor_1000_0)[tbd]

Group_GDI_cb	(GDIuuco_Rac1cgDp + GDIuuco_Rac1cgTp + GDIpuco_Rac1cgDp + GDIpuco_Rac1cgTp)[tbd]

Group_GDI_cf	(GDIuuco + GDIpuco)[tbd]

Group_GDI_py_m	0.0[tbd]

Group_GDI_py_c	0.0[tbd]

Group_gdiSp_m	(GDIpumo * VC_SpConcFactor_1000_0 / VC_SpConcFactor_1000_0)[tbd]

Group_gdiSp_c	(GDIpuco + GDIpuco_Rac1cgDp + GDIpuco_Rac1cgTp)[tbd]

Group_pak_m	0.0[tbd]

Group_pak_Ac_m	0.0[tbd]

Group_pak_Ac_c	pakpc[tbd]

g0	0.0[tbd]

tgluc	60.0[tbd]

gef0_R1	10.0[tbd]

changekonM	0.0[tbd]

coef_pld0	2.0[tbd]

change_gef_only	0.0[tbd]

coef_gef	5.0[tbd]

KD4_sys	(koff_granule * koff_membrane * SfRAVolNIH3T3 / (1.0E-20 + (koff_membrane * konGr_R1 * SfcGr) + (koff_granule * konM_R1 * SfRAVol)))[tbd]

koff_granule	(((koffGrD_R1 * Rac1ggDp) + (koffGrT_R1 * Rac1ggTp)) / (1.0E-20 + Rac1ggDp + Rac1ggTp))[tbd]

koff_membrane	(((koffMD_R1 * Rac1mgDp) + (koffMT_R1 * Rac1mgTp)) / (1.0E-20 + Rac1mgDp + Rac1mgTp))[tbd]

KD4_sys_c	((Rac1cgDp + Rac1cgTp) / (0.0016611295681063123 * (((Rac1mgDp + Rac1mgTp) * SfRAVol) + ((Rac1ggDp + Rac1ggTp) * SfcGr))))[tbd]