Physiology

Reaction Diagram

reactionDiagram

Cross-References

Annotations

Reactions

Reactions
Name
Structure
Kinetics
Depiction
GDIuuco_Rac1cgTpGDIuuco+Rac1cgTp R20 Cytoplasm GeneralKinetics
Rac1cgDpRac1ggDp R14 Granules GeneralKinetics
Rac1mgDpRac1mgTp R15 Membrane GeneralKinetics
Rac1cgDpRac1mgDp R11 Membrane GeneralKinetics
Rac1mgTpRac1cgTp R13 Membrane GeneralKinetics
GDIpuco+Rac1cgDpGDIpuco_Rac1cgDp R21 Cytoplasm GeneralKinetics
Rac1ggDpRac1ggTp R31 Granules GeneralKinetics
GDIpuco+Rac1cgTpGDIpuco_Rac1cgTp R35 Cytoplasm GeneralKinetics
Rac1cgDpRac1cgTp R17 Cytoplasm GeneralKinetics
GDIuuco+Rac1cgDpGDIuuco_Rac1cgDp R18 Cytoplasm GeneralKinetics
PLDmaTrashm R41 Membrane GeneralKinetics
PLDgiPLDci R1 Granules GeneralKinetics
GDIuucoGDIuumo R2 Membrane GeneralKinetics
GDIuucoGDIuugo R4 Granules GeneralKinetics
GDIpucoGDIpugo R5 Granules GeneralKinetics
pakucpakpc R6 Cytoplasm GeneralKinetics
GDIuucoGDIpuco R7 Cytoplasm GeneralKinetics
NonGlucLcGlucLc R9 Cytoplasm GeneralKinetics
GDIpucoGDIpumo R3 Membrane GeneralKinetics
Rac1cgTpRac1ggTp R30 Granules GeneralKinetics
PLDmiTrashm R36 Membrane GeneralKinetics
PLDciPLDmi R22 Membrane GeneralKinetics
PLDmiPLDma R37 Membrane GeneralKinetics

Structures

Name
Type
Electrical
Granules Membrane inGranules(+)   Cytoplasm(-)
Membrane Membrane Cytoplasm(+)   Extracellular(-)
Extracellular Compartment (+)   (-)
Cytoplasm Compartment (+)   (-)
inGranules Compartment (+)   (-)

Species

Name
Structure
BioNetGen Definition
Depiction
GDIuuco_Rac1cgTp Cytoplasm Cytoplasm
GDIuumo_Rac1mgDp Membrane Membrane
GDIuumo_Rac1mgTp Membrane Membrane
Rac1mgDp Membrane Membrane
Rac1mgTp Membrane Membrane
pakuc Cytoplasm Cytoplasm
NonGlucLc Cytoplasm Cytoplasm
glucc Cytoplasm Cytoplasm
GlucLc Cytoplasm Cytoplasm
PLDgi Granules Granules
Trashm Membrane Membrane
PLDci Cytoplasm Cytoplasm
GDIuumo Membrane Membrane
GDIpumo Membrane Membrane
GDIuugo Granules Granules
GDIpugo Granules Granules
pakpc Cytoplasm Cytoplasm
Rac1cgTp Cytoplasm Cytoplasm
Rac1ggDp Granules Granules
GDIpuco_Rac1cgDp Cytoplasm Cytoplasm
PLDmi Membrane Membrane
Rac1ggTp Granules Granules
GDIpuco_Rac1cgTp Cytoplasm Cytoplasm
PLDma Membrane Membrane
GDIuuco Cytoplasm Cytoplasm
GDIpuco Cytoplasm Cytoplasm
Rac1cgDp Cytoplasm Cytoplasm
GDIuuco_Rac1cgDp Cytoplasm Cytoplasm

Molecules

Name
BioNetGen Definition
DEPICTION

Observables

Name
Structure
Count
BNGL Definition
Sequence Type
DEPICTION

Applications

Name
Properties Math Type
Annotation
psGDIfactor_R1=0.1; find SS with no gluc Specs - Species
Specs - Reaction
Simulations
Deterministic (ODE) Compartmental (copied from C:\Documents and Settings\cfalkenberg\.vcell\BioNetGen\vcell_bng_1222\vcell_bng_1222_Compartmental)
psGDIfactor_R1=0.1+change konM+coefonGR; transient studies Specs - Species
Specs - Reaction
Simulations
Deterministic (ODE) Compartmental (copied from psGDIfactor_R1=0.1; transient studies) (copied from psGDIfactor_R1=0; transient studies) (copied from C:\Documents and Settings\cfalkenberg\.vcell\BioNetGen\vcell_bng_1222\vcell_bng_1222_Compartmental)

Specifications (Species) - psGDIfactor_R1=0.1; find SS with no gluc go to Simulations

Species
Initial Condition
Diffusion Constant
Structure
GDIuuco_Rac1cgTp 0.0 [uM] 0.0 [um2/s] Cytoplasm
pakuc 0.5 [uM] 0.0 [um2/s] Cytoplasm
NonGlucLc 1.0 [uM] 0.0 [um2/s] Cytoplasm
glucc 0.0 [uM] 0.0 [um2/s] Cytoplasm
GlucLc 0.0 [uM] 0.0 [um2/s] Cytoplasm
PLDci 0.0 [uM] 0.0 [um2/s] Cytoplasm
pakpc 0.0 [uM] 0.0 [um2/s] Cytoplasm
Rac1cgTp 0.0 [uM] 0.0 [um2/s] Cytoplasm
GDIpuco_Rac1cgDp 0.0 [uM] 0.0 [um2/s] Cytoplasm
GDIpuco_Rac1cgTp 0.0 [uM] 0.0 [um2/s] Cytoplasm
GDIuuco 0.07 [uM] 0.0 [um2/s] Cytoplasm
GDIpuco 0.06 [uM] 0.0 [um2/s] Cytoplasm
Rac1cgDp 0.0427 [uM] 0.0 [um2/s] Cytoplasm
GDIuuco_Rac1cgDp 0.11 [uM] 0.0 [um2/s] Cytoplasm
PLDgi 2.7777777777777777 [uM] 0.0 [um2/s] Granules
GDIuugo 0.0 [uM] 0.0 [um2/s] Granules
GDIpugo 0.0 [uM] 0.0 [um2/s] Granules
Rac1ggDp 0.0 [uM] 0.0 [um2/s] Granules
Rac1ggTp 0.0 [uM] 0.0 [um2/s] Granules
GDIuumo_Rac1mgDp 0.0 [uM] 0.0 [um2/s] Membrane
GDIuumo_Rac1mgTp 0.0 [uM] 0.0 [um2/s] Membrane
Rac1mgDp 0.0 [uM] 0.0 [um2/s] Membrane
Rac1mgTp 0.0 [uM] 0.0 [um2/s] Membrane
Trashm 601999.9999999999 [uM] 0.0 [um2/s] Membrane
GDIuumo 0.0 [uM] 0.0 [um2/s] Membrane
GDIpumo 0.0 [uM] 0.0 [um2/s] Membrane
PLDmi 0.0 [uM] 0.0 [um2/s] Membrane
PLDma 0.0 [uM] 0.0 [um2/s] Membrane

Specifications (Reaction) - psGDIfactor_R1=0.1; find SS with no gluc go to Simulations

Name
Enabled?
R20 included
R14 included
R15 included
R11 included
R13 included
R21 included
R31 included
R35 included
R17 included
R18 included
R41 included
R1 included
R2 included
R4 included
R5 included
R6 included
R7 included
R9 included
R3 included
R30 included
R36 included
R22 included
R37 included

Simulations - psGDIfactor_R1=0.1; find SS with no gluc go to Specifications

Name
End Time
Output Options
find SS 5000.0

KeepEvery 500

KeepAtMost 1000

Assignments

Name Variable Assignment Function Expression

Events

Name Trigger Type Variable Assignment
event0 on condition: (t > tgluc) glucc --> 20000.0, actPak --> (0.116 + (0.116 * changePsGDI)), gef_R1 --> (gef0_R1 + (((gef0_R1 * coef_gef) - gef0_R1) * change_gef_only))

Geometry Compartmental1146174258

(Origin: 0.0, 0.0, 0.0; Extent: 10.0, 10.0, 10.0 [um])

Dimension Type Subdomain Adjacent Subvolumes Size Mapped Compartment
Compartmental Compartment Membrane

Events

Name Variable Rate Expression

Specifications (Species) - psGDIfactor_R1=0.1+change konM+coefonGR; transient studies go to Simulations

Species
Initial Condition
Diffusion Constant
Structure
GDIuuco_Rac1cgTp 1.6563957705568633E-4 [uM] 0.0 [um2/s] Cytoplasm
pakuc 0.11240310077519382 [uM] 0.0 [um2/s] Cytoplasm
NonGlucLc 1.0 [uM] 0.0 [um2/s] Cytoplasm
glucc 0.0 [uM] 0.0 [um2/s] Cytoplasm
GlucLc 0.0 [uM] 0.0 [um2/s] Cytoplasm
PLDci 0.0 [uM] 0.0 [um2/s] Cytoplasm
pakpc 0.38759689922480617 [uM] 0.0 [um2/s] Cytoplasm
Rac1cgTp 3.622850570650371E-7 [uM] 0.0 [um2/s] Cytoplasm
GDIpuco_Rac1cgDp 0.011582451335819324 [uM] 0.0 [um2/s] Cytoplasm
GDIpuco_Rac1cgTp 1.9214186222063993E-5 [uM] 0.0 [um2/s] Cytoplasm
GDIuuco 0.05943702212607566 [uM] 0.0 [um2/s] Cytoplasm
GDIpuco 0.06894692985331065 [uM] 0.0 [um2/s] Cytoplasm
Rac1cgDp 2.183880698389099E-4 [uM] 0.0 [um2/s] Cytoplasm
GDIuuco_Rac1cgDp 0.09984874292151663 [uM] 0.0 [um2/s] Cytoplasm
PLDgi 2.7777777777777777 [uM] 0.0 [um2/s] Granules
GDIuugo 0.0 [uM] 0.0 [um2/s] Granules
GDIpugo 0.0 [uM] 0.0 [um2/s] Granules
Rac1ggDp 4.770672010383799 [uM] 0.0 [um2/s] Granules
Rac1ggTp 0.0031608535148760723 [uM] 0.0 [um2/s] Granules
GDIuumo_Rac1mgDp 0.0 [uM] 0.0 [um2/s] Membrane
GDIuumo_Rac1mgTp 0.0 [uM] 0.0 [um2/s] Membrane
Rac1mgDp 4.554384740079095 [uM] 0.0 [um2/s] Membrane
Rac1mgTp 2.9446676851097253 [uM] 0.0 [um2/s] Membrane
Trashm 601999.9999999999 [uM] 0.0 [um2/s] Membrane
GDIuumo 0.0 [uM] 0.0 [um2/s] Membrane
GDIpumo 0.0 [uM] 0.0 [um2/s] Membrane
PLDmi 0.0 [uM] 0.0 [um2/s] Membrane
PLDma 0.0 [uM] 0.0 [um2/s] Membrane

Specifications (Reaction) - psGDIfactor_R1=0.1+change konM+coefonGR; transient studies go to Simulations

Name
Enabled?
R20 included
R14 included
R15 included
R11 included
R13 included
R21 included
R31 included
R35 included
R17 included
R18 included
R41 included
R1 included
R2 included
R4 included
R5 included
R6 included
R7 included
R9 included
R3 included
R30 included
R36 included
R22 included
R37 included

Simulations - psGDIfactor_R1=0.1+change konM+coefonGR; transient studies go to Specifications

Name
End Time
Output Options
effect of ps-gdi only 4000.0

KeepEvery 500

KeepAtMost 1000

effect of increase konM over t; coef on Gr=0; coef pld0=1.5 4000.0

KeepEvery 500

KeepAtMost 1000

effect of increase konM and konGr: coef on Gr=1.5; coef pld0=[1,1.5,2] 4000.0

KeepEvery 500

KeepAtMost 1000

effect of increase konM and konGr: coef on Gr=2; coef pld0=[1,1.5,2] 4000.0

KeepEvery 500

KeepAtMost 1000

Assignments

Name Variable Assignment Function Expression

Events

Name Trigger Type Variable Assignment
event0 on condition: (t > tgluc) glucc --> 20000.0, actPak --> (0.116 + (0.116 * changePsGDI)), gef_R1 --> (gef0_R1 + (((gef0_R1 * coef_gef) - gef0_R1) * change_gef_only))

Geometry Compartmental1146174258

(Origin: 0.0, 0.0, 0.0; Extent: 10.0, 10.0, 10.0 [um])

Dimension Type Subdomain Adjacent Subvolumes Size Mapped Compartment
Compartmental Compartment Membrane

Events

Name Variable Rate Expression

Global Parameters

Name
Expression
SfRAVolNIH3T3 0.524[tbd]
SfRAVol 0.587[tbd]
toexport2 1.0E-12[tbd]
FR 1.0[tbd]
fusRate ((1.67E-5 * (t >= (600.0 + tgluc))) + (2.779166666666666E-7 * (t > (60.0 + tgluc)) * (t < (300.0 + tgluc)) * ( - (60.0 + tgluc) + t)) + ((t >= (300.0 + tgluc)) * (t < (600.0 + tgluc)) * (6.67E-5 - (1.6666666666666668E-7 * ( - (300.0 + tgluc) + t)))))[tbd]
coef_on_Gr 1.0[tbd]
actPLD 0.1[tbd]
inacPLD 0.1[tbd]
actPak 0.116[tbd]
coefP_G_s 0.02[tbd]
changePsGDI 0.0[tbd]
gluc0 glucc[tbd]
KDM_G 10.0[tbd]
koffM_G 1.0[tbd]
KDMp_G 0.1[tbd]
koffMp_G 0.1[tbd]
KDGr_G 10.0[tbd]
koffGr_G 1.0[tbd]
KDGrp_G 0.1[tbd]
koffGrp_G 0.1[tbd]
kon_Pak_G 1.0[tbd]
koff_Pak_G 1.0[tbd]
alphaPak 1.0[tbd]
KD_pak_C2 2.9[tbd]
KD_pak_R1 0.7[tbd]
koffPak_C2 1.0[tbd]
koffPak_R1 1.0[tbd]
gtpm_C2 1.0[tbd]
gtpm_R1 1.0[tbd]
dP_pak 0.1[tbd]
P_R1 0.0[tbd]
dP_R1 0.0[tbd]
pld0 (changekonM * PLDma / (0.1 + PLDma))[tbd]
koffMD_R1 0.1496[tbd]
koffMT_R1 0.011[tbd]
koffGrD_R1 0.1496[tbd]
koffGrT_R1 0.011[tbd]
gef_R1 gef0_R1[tbd]
gef_Cyt_R1 0.0[tbd]
gef_Gr_R1 0.01[tbd]
KDD_2d_R1 1.0[tbd]
KDT_2d_R1 1.0[tbd]
koff1_2d_R1 0.0[tbd]
phospFactor2_R1 1.0[tbd]
koff1P_2d_R1 0.0[tbd]
geomFac25_R1 1.0[tbd]
koff1_25d_R1 0.0[tbd]
phospFactor25_R1 1.0[tbd]
koff1P_25d_R1 0.0[tbd]
alpha_R1 1.0[tbd]
koff1_3d_R1 0.044[tbd]
phospFactor3_R1 1.0[tbd]
koff1P_3d_R1 0.044[tbd]
koffMD_gG_R1 0.1496[tbd]
koffMT_gG_R1 0.1496[tbd]
konM_gG_R1 0.0[tbd]
konE_R1 0.1[tbd]
koffE_R1 0.1[tbd]
pGdifactor_R1 0.1[tbd]
psGdifactor_R1 0.1[tbd]
konGluc 1.0E-7[tbd]
koffGluc 0.001[tbd]
Vol2Sfc (1.0 / SfRAVol)[tbd]
SfcGr 4.230317273795534[tbd]
VolGr 0.23501762632197415[tbd]
VolCyt2SfcGr (1.0 / SfcGr)[tbd]
toexportM 0.0019083969465648854[tbd]
toexport1 (0.001 * Vol2Sfc)[tbd]
toexport1gr (0.001 * VolCyt2SfcGr)[tbd]
pmp (toexportM * toexport2)[tbd]
pmp0 toexport2[tbd]
pmpGr (toexportM * toexport2)[tbd]
P_G_s (actPak * coefP_G_s)[tbd]
dP_G_s (0.1 * coefP_G_s)[tbd]
konM_G 0.0[tbd]
konMp_G 0.0[tbd]
konGr_G 0.0[tbd]
konGrp_G 0.0[tbd]
konPak_C2 (koffPak_C2 / KD_pak_C2)[tbd]
konPak_R1 (koffPak_R1 / KD_pak_R1)[tbd]
P_pak (alphaPak * gtpm_C2 / KD_pak_C2)[tbd]
konM_R1 (2.84 * (1.0 + (coef_pld0 * pld0)))[tbd]
konGr_R1 (2.84 * (1.0 + (coef_on_Gr * pld0)))[tbd]
gap_R1 (1.5455950540958268 * gef0_R1)[tbd]
gap_Cyt_R1 (4.0 * gap_R1)[tbd]
gap_Gr_R1 gap_R1[tbd]
koffD_2d_R1 koff1_2d_R1[tbd]
koffT_2d_R1 koff1_2d_R1[tbd]
konD_2d_R1 (koffD_2d_R1 / KDD_2d_R1)[tbd]
konT_2d_R1 (koffT_2d_R1 / KDT_2d_R1)[tbd]
KDDP_2d_R1 (KDD_2d_R1 / phospFactor2_R1)[tbd]
KDTP_2d_R1 (KDD_2d_R1 / phospFactor2_R1)[tbd]
koffDP_2d_R1 koff1P_2d_R1[tbd]
koffTP_2d_R1 koff1P_2d_R1[tbd]
konDP_2d_R1 (koffDP_2d_R1 / KDDP_2d_R1)[tbd]
konTP_2d_R1 (koffTP_2d_R1 / KDTP_2d_R1)[tbd]
KDD_25d_R1 (5.2E-4 / geomFac25_R1)[tbd]
KDT_25d_R1 (5.2E-4 / geomFac25_R1)[tbd]
koffD_25d_R1 koff1_25d_R1[tbd]
koffT_25d_R1 koff1_25d_R1[tbd]
konD_25d_R1 (koffD_25d_R1 / KDD_25d_R1)[tbd]
konT_25d_R1 (koffT_25d_R1 / KDT_25d_R1)[tbd]
KDDP_25d_R1 (KDD_25d_R1 / phospFactor25_R1)[tbd]
KDTP_25d_R1 (KDD_25d_R1 / phospFactor25_R1)[tbd]
koffDP_25d_R1 koff1P_25d_R1[tbd]
koffTP_25d_R1 koff1P_25d_R1[tbd]
konDP_25d_R1 (koffDP_25d_R1 / KDDP_25d_R1)[tbd]
konTP_25d_R1 (koffTP_25d_R1 / KDTP_25d_R1)[tbd]
KDD_3d_R1 (1.3E-4 * alpha_R1)[tbd]
KDT_3d_R1 (1.3E-4 * alpha_R1)[tbd]
koffD_3d_R1 koff1_3d_R1[tbd]
koffT_3d_R1 koff1_3d_R1[tbd]
konD_3d_R1 (koffD_3d_R1 / KDD_3d_R1)[tbd]
konT_3d_R1 (koffT_3d_R1 / KDT_3d_R1)[tbd]
KDDP_3d_R1 (KDD_3d_R1 / phospFactor3_R1)[tbd]
KDTP_3d_R1 (KDD_3d_R1 / phospFactor3_R1)[tbd]
koffDP_3d_R1 koff1P_3d_R1[tbd]
koffTP_3d_R1 koff1P_3d_R1[tbd]
konDP_3d_R1 (koffDP_3d_R1 / KDDP_3d_R1)[tbd]
konTP_3d_R1 (koffTP_3d_R1 / KDTP_3d_R1)[tbd]
ppGdifactor_R1 (pGdifactor_R1 * psGdifactor_R1)[tbd]
InitialConc1 0.0[tbd]
InitialConc2 0.0[tbd]
InitialConc3 0.0[tbd]
InitialConc4 0.0[tbd]
InitialConc5 (pmpGr / pmp0)[tbd]
rateParam1 (fusRate * pmp0)[tbd]
rateParam2 (1.0E10 * fusRate * pmpGr)[tbd]
rateParam3 (7.2 * fusRate * pmp0)[tbd]
rateParam4 (koffM_G * pmp0)[tbd]
rateParam5 (konM_G * pmp)[tbd]
rateParam6 (koffMp_G * pmp0)[tbd]
rateParam7 (konMp_G * pmp)[tbd]
rateParam8 (koffGr_G * pmp0)[tbd]
rateParam9 (konGr_G * pmp)[tbd]
rateParam10 (koffGrp_G * pmp0)[tbd]
rateParam11 (konGrp_G * pmp)[tbd]
rateParam12 (konGluc * gluc0)[tbd]
rateParam13 (konM_R1 * pmp)[tbd]
rateParam14 (koffMD_R1 * pmp0)[tbd]
rateParam15 (konM_R1 * pmp)[tbd]
rateParam16 (koffMT_R1 * pmp0)[tbd]
rateParam17 (konGr_R1 * pmpGr)[tbd]
rateParam18 (koffGrD_R1 * pmp0)[tbd]
rateParam19 (konGr_R1 * pmpGr)[tbd]
rateParam20 (koffGrT_R1 * pmp0)[tbd]
rateParam21 (gef_R1 * pmp0)[tbd]
rateParam22 (gap_R1 * pmp0)[tbd]
rateParam23 (gef_Gr_R1 * pmp0)[tbd]
rateParam24 (gap_Gr_R1 * pmp0)[tbd]
rateParam25 (pGdifactor_R1 * konD_3d_R1)[tbd]
rateParam26 (pGdifactor_R1 * konT_3d_R1)[tbd]
rateParam27 (psGdifactor_R1 * konD_3d_R1)[tbd]
rateParam28 (psGdifactor_R1 * konT_3d_R1)[tbd]
Group_nonG NonGlucLc[tbd]
Group_glucL GlucLc[tbd]
VC_SpConcFactor_1000_0 1.6611295681063123E-6 [1000]
Group_Rac1 (Rac1cgDp + GDIuuco_Rac1cgDp + GDIuuco_Rac1cgTp + (GDIuumo_Rac1mgDp * VC_SpConcFactor_1000_0) + (GDIuumo_Rac1mgTp * VC_SpConcFactor_1000_0) + (Rac1mgDp * VC_SpConcFactor_1000_0) + (Rac1mgTp * VC_SpConcFactor_1000_0) + Rac1cgTp + (Rac1ggDp * VC_SpConcFactor_1000_0) + GDIpuco_Rac1cgDp + (Rac1ggTp * VC_SpConcFactor_1000_0) + GDIpuco_Rac1cgTp)[tbd]
Group_GDI (GDIuuco + GDIpuco + GDIuuco_Rac1cgDp + GDIuuco_Rac1cgTp + (GDIuumo_Rac1mgDp * VC_SpConcFactor_1000_0) + (GDIuumo_Rac1mgTp * VC_SpConcFactor_1000_0) + (GDIuumo * VC_SpConcFactor_1000_0) + (GDIpumo * VC_SpConcFactor_1000_0) + (GDIuugo * VC_SpConcFactor_1000_0) + (GDIpugo * VC_SpConcFactor_1000_0) + GDIpuco_Rac1cgDp + GDIpuco_Rac1cgTp)[tbd]
Group_pak (pakuc + pakpc)[tbd]
Group_tot_Rac1_M (((GDIuumo_Rac1mgDp * VC_SpConcFactor_1000_0) + (GDIuumo_Rac1mgTp * VC_SpConcFactor_1000_0) + (Rac1mgDp * VC_SpConcFactor_1000_0) + (Rac1mgTp * VC_SpConcFactor_1000_0)) / VC_SpConcFactor_1000_0)[tbd]
Group_tot_Rac1_G (((Rac1ggDp * VC_SpConcFactor_1000_0) + (Rac1ggTp * VC_SpConcFactor_1000_0)) / VC_SpConcFactor_1000_0)[tbd]
Group_tot_Rac1_C (Rac1cgDp + GDIuuco_Rac1cgDp + GDIuuco_Rac1cgTp + Rac1cgTp + GDIpuco_Rac1cgDp + GDIpuco_Rac1cgTp)[tbd]
Group_Rac1_Mfree (((Rac1mgDp * VC_SpConcFactor_1000_0) + (Rac1mgTp * VC_SpConcFactor_1000_0)) / VC_SpConcFactor_1000_0)[tbd]
Group_Rac1_GDP_m (((GDIuumo_Rac1mgDp * VC_SpConcFactor_1000_0) + (Rac1mgDp * VC_SpConcFactor_1000_0)) / VC_SpConcFactor_1000_0)[tbd]
Group_Rac1_GTP_m (((GDIuumo_Rac1mgTp * VC_SpConcFactor_1000_0) + (Rac1mgTp * VC_SpConcFactor_1000_0)) / VC_SpConcFactor_1000_0)[tbd]
Group_Rac1_GDP_c (Rac1cgDp + GDIuuco_Rac1cgDp + GDIpuco_Rac1cgDp)[tbd]
Group_Rac1_GTP_c (GDIuuco_Rac1cgTp + Rac1cgTp + GDIpuco_Rac1cgTp)[tbd]
Group_Rac1_c_g (GDIuuco_Rac1cgDp + GDIpuco_Rac1cgDp)[tbd]
Group_GDI_c (GDIuuco + GDIpuco + GDIuuco_Rac1cgDp + GDIuuco_Rac1cgTp + GDIpuco_Rac1cgDp + GDIpuco_Rac1cgTp)[tbd]
Group_GDI_m (((GDIuumo_Rac1mgDp * VC_SpConcFactor_1000_0) + (GDIuumo_Rac1mgTp * VC_SpConcFactor_1000_0) + (GDIuumo * VC_SpConcFactor_1000_0) + (GDIpumo * VC_SpConcFactor_1000_0)) / VC_SpConcFactor_1000_0)[tbd]
Group_GDI_g (((GDIuugo * VC_SpConcFactor_1000_0) + (GDIpugo * VC_SpConcFactor_1000_0)) / VC_SpConcFactor_1000_0)[tbd]
Group_GDI_mb_g (((GDIuumo_Rac1mgDp * VC_SpConcFactor_1000_0) + (GDIuumo_Rac1mgTp * VC_SpConcFactor_1000_0)) / VC_SpConcFactor_1000_0)[tbd]
Group_GDI_mf (((GDIuumo * VC_SpConcFactor_1000_0) + (GDIpumo * VC_SpConcFactor_1000_0)) / VC_SpConcFactor_1000_0)[tbd]
Group_GDI_cb (GDIuuco_Rac1cgDp + GDIuuco_Rac1cgTp + GDIpuco_Rac1cgDp + GDIpuco_Rac1cgTp)[tbd]
Group_GDI_cf (GDIuuco + GDIpuco)[tbd]
Group_GDI_py_m 0.0[tbd]
Group_GDI_py_c 0.0[tbd]
Group_gdiSp_m (GDIpumo * VC_SpConcFactor_1000_0 / VC_SpConcFactor_1000_0)[tbd]
Group_gdiSp_c (GDIpuco + GDIpuco_Rac1cgDp + GDIpuco_Rac1cgTp)[tbd]
Group_pak_m 0.0[tbd]
Group_pak_Ac_m 0.0[tbd]
Group_pak_Ac_c pakpc[tbd]
g0 0.0[tbd]
tgluc 60.0[tbd]
gef0_R1 10.0[tbd]
changekonM 0.0[tbd]
coef_pld0 2.0[tbd]
change_gef_only 0.0[tbd]
coef_gef 5.0[tbd]
KD4_sys (koff_granule * koff_membrane * SfRAVolNIH3T3 / (1.0E-20 + (koff_membrane * konGr_R1 * SfcGr) + (koff_granule * konM_R1 * SfRAVol)))[tbd]
koff_granule (((koffGrD_R1 * Rac1ggDp) + (koffGrT_R1 * Rac1ggTp)) / (1.0E-20 + Rac1ggDp + Rac1ggTp))[tbd]
koff_membrane (((koffMD_R1 * Rac1mgDp) + (koffMT_R1 * Rac1mgTp)) / (1.0E-20 + Rac1mgDp + Rac1mgTp))[tbd]
KD4_sys_c ((Rac1cgDp + Rac1cgTp) / (0.0016611295681063123 * (((Rac1mgDp + Rac1mgTp) * SfRAVol) + ((Rac1ggDp + Rac1ggTp) * SfcGr))))[tbd]