Reaction Diagram
Physiology
Universal ID's | Text Annotations |
---|---|
|
|
Reaction |
Name
Structure
|
Kinetics | Depiction |
---|---|---|---|
MekMek_act |
Mek_Activation
cell
|
GeneralKinetics | MekMek_act |
|
|
reaction rate (J): (Kcat * Raf1_act * Mek / (km + Mek))[mmol.ml-1.min-1]
user defined (km): 4768350.0[mmol.ml-1] user defined (Kcat): 185.759[min-1] |
|
Mek_actMek |
Mek_Deactivation
cell
|
GeneralKinetics | Mek_actMek |
|
|
reaction rate (J): (Kcat * PP2A_act * Mek_act / (km + Mek_act))[mmol.ml-1.min-1]
user defined (km): 518753.0[mmol.ml-1] user defined (Kcat): 2.83243[min-1] |
|
MekMek_act |
Mek_Activation_bRaf
cell
|
GeneralKinetics | MekMek_act |
|
|
reaction rate (J): (kcat * bRaf_act * Mek / (km + Mek))[mmol.ml-1.min-1]
user defined (km): 4768350.0[mmol.ml-1] user defined (kcat): 185.759[min-1] |
Name |
Type
Electrical (Membrane Polarity)
|
---|---|
cell |
Compartment
(+) (-)
|
|
|
Name | Structure | BioNetGen Definition |
---|---|---|
Raf1_act | cell | Raf(Active~yes!-,). |
|
|
|
Mek_act | cell | MEK(Active~yes!-,). |
|
|
|
Mek | cell | MEK(Active~no!-,). |
|
|
|
bRaf_act | cell | B_Raf(Active~yes!-,). |
|
|
|
PP2A_act | cell | PP2A(Active~yes!-,). |
|
|
Name | Text Annotations | BioNetGen Definition |
---|---|---|
Raf | Text Annotations | Raf(Active~yes~no,) |
|
|
|
MEK | Text Annotations | MEK(Active~yes~no,) |
|
|
|
B_Raf | Text Annotations | B_Raf(Active~yes~no,) |
|
|
|
PP2A | Text Annotations | PP2A(Active~yes~no,) |
|
|
Name |
Type
Count
|
BioNetGen Definition |
---|
Applications
Name | Math Type | Annotation |
---|---|---|
Deterministic | Deterministic (ODE) Compartmental | cloned from 'Deterministic' owned by user savi06 cloned from 'Deterministic' owned by user mblinov cloned from 'Deterministic' owned by user cab15130 |
Application - Deterministic
Species | Initial Condition | Diffusion Constant | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Raf1_act | (1800.0 * (t > 1.0) * (t < 3.0)) [mmol] | 0.0
[m2/min] Mek_act |
0.0
[mmol]
|
0.0
[m2/min] | Mek |
600000.0
[mmol]
|
0.0
[m2/min] | bRaf_act |
(14000.0 * (t > 1.0) * (t < 7.0))
[mmol]
|
0.0
[m2/min] | PP2A_act |
120000.0
[mmol]
|
0.0
[m2/min]
|
|
Name | Reaction Mapping |
---|---|
Mek_Activation | included |
Mek_Deactivation | included |
Mek_Activation_bRaf | included |
Name | End Time | Output Options |
---|---|---|
Simulation0 | 10.0 [min] |
KeepEvery 1 KeepAtMost 1000 |
Name | Variable | Assignment Function Expression |
---|---|---|
assignmentRule0 | Raf1_act | (1800.0 * (t > 1.0) * (t < 3.0)) |
assignmentRule1 | bRaf_act | (14000.0 * (t > 1.0) * (t < 7.0)) |
Dimension | Type | Subdomain | Adjacent Subvolumes | Size | Mapped Compartment |
---|---|---|---|---|---|
Compartmental | Compartment | cell |
Global Parameters
Name | Expression |
---|