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Name - Activation_Mek

BioModel ID - 205506027

Reaction Diagram

reactionDiagram

Physiology

Universal ID's	Text Annotations

Reactions See in Dashboard
Reaction	Name Structure	Kinetics
Mek-->Mek_act	Mek_Activation cell	GeneralKinetics
Universal ID's:	Text Annotations:	reaction rate (J): (Kcat * Raf1_act * Mek / (km + Mek))[mmol.ml-1.min-1] user defined (km): 4768350.0[mmol.ml-1] user defined (Kcat): 185.759[min-1]
Mek_act-->Mek	Mek_Deactivation cell	GeneralKinetics
Universal ID's:	Text Annotations:	reaction rate (J): (Kcat * PP2A_act * Mek_act / (km + Mek_act))[mmol.ml-1.min-1] user defined (km): 518753.0[mmol.ml-1] user defined (Kcat): 2.83243[min-1]
Mek-->Mek_act	Mek_Activation_bRaf cell	GeneralKinetics
Universal ID's:	Text Annotations:	reaction rate (J): (kcat * bRaf_act * Mek / (km + Mek))[mmol.ml-1.min-1] user defined (km): 4768350.0[mmol.ml-1] user defined (kcat): 185.759[min-1]

Structures See in Dashboard
Name	Type Electrical (Membrane Polarity)
cell	Compartment (+) (-)
Universal ID's:	Text Annotations:

Species See in Dashboard
Name	Structure	BioNetGen Definition
Raf1_act	cell	Raf(Active~yes!-,).
Universal ID's:	Text Annotations:
Mek_act	cell	MEK(Active~yes!-,).
Universal ID's:	Text Annotations:
Mek	cell	MEK(Active~no!-,).
Universal ID's:	Text Annotations:
bRaf_act	cell	B_Raf(Active~yes!-,).
Universal ID's:	Text Annotations:
PP2A_act	cell	PP2A(Active~yes!-,).
Universal ID's:	Text Annotations:

Molecules See in Dashboard
Name	Text Annotations	BioNetGen Definition
Raf	Text Annotations	Raf(Active~yes~no,)
Universal ID's:
MEK	Text Annotations	MEK(Active~yes~no,)
Universal ID's:
B_Raf	Text Annotations	B_Raf(Active~yes~no,)
Universal ID's:
PP2A	Text Annotations	PP2A(Active~yes~no,)
Universal ID's:

Observables See in Dashboard
Name	Type Count	BioNetGen Definition

Applications

Applications See in Dashboard
Name	Math Type	Annotation
Deterministic	Deterministic (ODE) Compartmental	cloned from 'Deterministic' owned by user savi06 cloned from 'Deterministic' owned by user mblinov cloned from 'Deterministic' owned by user cab15130

0 - Deterministic

Specifications(Species) - Deterministic See in Dashboard
Species	Initial Condition	Diffusion Constant
Raf1_act	(1800.0 * (t > 1.0) * (t < 3.0))	0.0 [m2/min]
Mek_act	0.0	0.0 [m2/min]
Mek	600000.0	0.0 [m2/min]
bRaf_act	(14000.0 * (t > 1.0) * (t < 7.0))	0.0 [m2/min]
PP2A_act	120000.0	0.0 [m2/min]

Specifications(Reaction) - Deterministic See in Dashboard
Name	Reaction Mapping
Mek_Activation	included
Mek_Deactivation	included
Mek_Activation_bRaf	included

Simulations - Deterministic See in Dashboard
Name	End Time	Output Options
Simulation0	10.0 [min]	KeepEvery 1 KeepAtMost 1000

Global Parameters

Global Parameters See in Dashboard
Name	Expression