Physiology

Reaction Diagram

reactionDiagram

Cross-References

Annotations

Reactions

Reactions
Name
Structure
Kinetics
Mek Mek_act Mek_Activation cell GeneralKinetics
Mek_act Mek Mek_Deactivation cell GeneralKinetics
Mek Mek_act Mek_Activation_bRaf cell GeneralKinetics

Structures

Name
Type
Electrical
cell Compartment (+)   (-)

Species

Name
Structure
BioNetGen Definition
Depiction
Raf1_act cell Raf(Active~yes!-,).
Mek_act cell MEK(Active~yes!-,).
Mek cell MEK(Active~no!-,).
bRaf_act cell B_Raf(Active~yes!-,).
PP2A_act cell PP2A(Active~yes!-,).

Molecules

Name
BioNetGen Definition
DEPICTION
Raf Raf(Active~yes~no,)
MEK MEK(Active~yes~no,)
B_Raf B_Raf(Active~yes~no,)
PP2A PP2A(Active~yes~no,)

Observables

Name
Structure
Count
BNGL Definition
Sequence Type
DEPICTION

Applications

Specifications (Species) - Deterministic go to Simulations

Species
Initial Condition
Diffusion Constant
Raf1_act (1800.0 * (t > 1.0) * (t < 3.0)) 0.0
Mek_act 0.0 0.0
Mek 600000.0 0.0
bRaf_act (14000.0 * (t > 1.0) * (t < 7.0)) 0.0
PP2A_act 120000.0 0.0

Specifications (Reaction) - Deterministic go to Simulations

Name
Enabled?
Mek_Activation included
Mek_Deactivation included
Mek_Activation_bRaf included

Simulations - Deterministic go to Specifications

Name
End Time
Output Options
Simulation0 10.0 every

Global Parameters

Name
Expression

Downloads

Format
File
VCML VCML File
BNGL
MatLab
SBML
Formatted XML
SEDML