ModelBricks - Model Print Page

Name - 5HT7_Jang_2020

BioModel ID - 189321805

Reaction Diagram

Physiology

Universal ID's	Text Annotations

Reactions See in Dashboard
Reaction	Name Structure	Kinetics	Depiction
L_5HT_1L_5HT	inj1 EC	MassAction	L_5HT_1L_5HT
		reaction rate (J): ((Kf * L_5HT_1) - (Kr * L_5HT))[uM.s-1] forward rate constant (Kf): (50.0 * (t > start) * (t < end))[s-1] reverse rate constant (Kr): ((50.0 * (t > end)) * (t < start1))[s-1] user defined (start): 10500.0[s] user defined (end): 12000.0[s] user defined (start1): 12500.0[s]
L_5HT_2L_5HT	inj2 EC	MassAction	L_5HT_2L_5HT
		reaction rate (J): ((Kf * L_5HT_2) - (Kr * L_5HT))[uM.s-1] forward rate constant (Kf): (50.0 * (t > start1) * (t < end1))[s-1] reverse rate constant (Kr): ((50.0 * (t > end1)) * (t < start2))[s-1] user defined (start1): 12500.0[s] user defined (end1): 14000.0[s] user defined (start2): 14500.0[s]
L_5HT_3L_5HT	inj3 EC	MassAction	L_5HT_3L_5HT
		reaction rate (J): ((Kf * L_5HT_3) - (Kr * L_5HT))[uM.s-1] forward rate constant (Kf): (50.0 * (t > start2) * (t < end2))[s-1] reverse rate constant (Kr): ((50.0 * (t > end2)) * (t < start3))[s-1] user defined (end2): 16000.0[s] user defined (start2): 14500.0[s] user defined (start3): 16500.0[s]
L_5HT_4L_5HT	inj4 EC	MassAction	L_5HT_4L_5HT
		reaction rate (J): ((Kf * L_5HT_4) - (Kr * L_5HT))[uM.s-1] forward rate constant (Kf): (50.0 * (t > start3) * (t < end3))[s-1] reverse rate constant (Kr): ((50.0 * (t > end3)) * (t < start4))[s-1] user defined (end3): 18000.0[s] user defined (start3): 16500.0[s] user defined (start4): 18500.0[s]
L_5HT_5L_5HT	inj5 EC	MassAction	L_5HT_5L_5HT
		reaction rate (J): ((Kf * L_5HT_5) - (Kr * L_5HT))[uM.s-1] forward rate constant (Kf): (50.0 * (t > start4) * (t < end4))[s-1] reverse rate constant (Kr): ((50.0 * (t > end4)) * (t < start5))[s-1] user defined (end4): 20000.0[s] user defined (start4): 18500.0[s] user defined (start5): 20500.0[s]
L_5HT_6L_5HT	inj6 EC	MassAction	L_5HT_6L_5HT
		reaction rate (J): ((Kf * L_5HT_6) - (Kr * L_5HT))[uM.s-1] forward rate constant (Kf): (50.0 * (t > start5) * (t < end5))[s-1] reverse rate constant (Kr): ((50.0 * (t > end5)) * (t < start6))[s-1] user defined (end5): 22000.0[s] user defined (start5): 20500.0[s] user defined (start6): 22500.0[s]
L_5HT_7L_5HT	inj7 EC	MassAction	L_5HT_7L_5HT
		reaction rate (J): ((Kf * L_5HT_7) - (Kr * L_5HT))[uM.s-1] forward rate constant (Kf): (50.0 * (t > start6) * (t < end6))[s-1] reverse rate constant (Kr): ((50.0 * (t > end6)) * (t < start7))[s-1] user defined (end6): 24000.0[s] user defined (start6): 22500.0[s] user defined (start7): 24500.0[s]
L_5HT_8L_5HT	inj8 EC	MassAction	L_5HT_8L_5HT
		reaction rate (J): ((Kf * L_5HT_8) - (Kr * L_5HT))[uM.s-1] forward rate constant (Kf): (50.0 * (t > start7) * (t < end7))[s-1] reverse rate constant (Kr): ((50.0 * (t > end7)) * (t < start8))[s-1] user defined (end7): 26000.0[s] user defined (start7): 24500.0[s] user defined (start8): 26500.0[s]
L_5HT_9L_5HT	inj9 EC	MassAction	L_5HT_9L_5HT
		reaction rate (J): ((Kf * L_5HT_9) - (Kr * L_5HT))[uM.s-1] forward rate constant (Kf): (50.0 * (t > start8) * (t < end8))[s-1] reverse rate constant (Kr): ((50.0 * (t > end8)) * (t < start9))[s-1] user defined (end8): 28000.0[s] user defined (start8): 26500.0[s] user defined (start9): 28500.0[s]
L_5HT_10L_5HT	inj10 EC	MassAction	L_5HT_10L_5HT
		reaction rate (J): ((Kf * L_5HT_10) - (Kr * L_5HT))[uM.s-1] forward rate constant (Kf): (50.0 * (t > start9) * (t < end9))[s-1] reverse rate constant (Kr): ((50.0 * (t > end9)) * (t < start10))[s-1] user defined (end9): 30000.0[s] user defined (start9): 28500.0[s] user defined (start10): 30500.0[s]
L_5HT_11L_5HT	inj11 EC	MassAction	L_5HT_11L_5HT
		reaction rate (J): ((Kf * L_5HT_11) - (Kr * L_5HT))[uM.s-1] forward rate constant (Kf): (50.0 * (t > start10) * (t < end10))[s-1] reverse rate constant (Kr): ((50.0 * (t > end10)) * (t < start11))[s-1] user defined (end10): 32000.0[s] user defined (start10): 30500.0[s] user defined (start11): 32500.0[s]
L_5HT_12L_5HT	inj12 EC	MassAction	L_5HT_12L_5HT
		reaction rate (J): ((Kf * L_5HT_12) - (Kr * L_5HT))[uM.s-1] forward rate constant (Kf): (50.0 * (t > start11) * (t < end11))[s-1] reverse rate constant (Kr): ((50.0 * (t > end11)) * (t < start12))[s-1] user defined (start11): 32500.0[s] user defined (end11): 34000.0[s] user defined (start12): 34500.0[s]
L_5HT_13L_5HT	inj13 EC	MassAction	L_5HT_13L_5HT
		reaction rate (J): ((Kf * L_5HT_13) - (Kr * L_5HT))[uM.s-1] forward rate constant (Kf): (50.0 * (t > start12) * (t < end12))[s-1] reverse rate constant (Kr): ((50.0 * (t > end12)) * (t < start13))[s-1] user defined (start12): 34500.0[s] user defined (end12): 36000.0[s] user defined (start13): 36500.0[s]
ss1_5HTL_5HT	ss_1 EC	MassAction	ss1_5HTL_5HT
		reaction rate (J): ((Kf * ss1_5HT) - (Kr * L_5HT))[uM.s-1] forward rate constant (Kf): (50.0 * (t > start) * (t < end))[s-1] reverse rate constant (Kr): (50.0 * (t > end))[s-1] user defined (end): 2300.0[s] user defined (start): 530.0[s]
ss2_MTI_MT	ss_2 EC	MassAction	ss2_MTI_MT
		reaction rate (J): ((Kf * ss2_MT) - (Kr * I_MT))[uM.s-1] forward rate constant (Kf): (50.0 * (t > start))[s-1] reverse rate constant (Kr): 0.0[s-1] user defined (start): 575.0[s]
GDP_ICGDP_free	GDP_Inj IC	MassAction	GDP_ICGDP_free
		reaction rate (J): ((Kf * GDP_IC) - (Kr * GDP_free))[uM.s-1] forward rate constant (Kf): (50.0 * (t > start))[s-1] reverse rate constant (Kr): 0.0[s-1] user defined (start): 0.0[s]
GTP_ICGTP_free	GTP_Inj IC	MassAction	GTP_ICGTP_free
		reaction rate (J): ((Kf * GTP_IC) - (Kr * GTP_free))[uM.s-1] forward rate constant (Kf): (50.0 * (t > start))[s-1] reverse rate constant (Kr): 0.0[s-1] user defined (start): 0.0[s]
L_5HT_14L_5HT	inj14 EC	MassAction	L_5HT_14L_5HT
		reaction rate (J): ((Kf * L_5HT_14) - (Kr * L_5HT))[uM.s-1] forward rate constant (Kf): (50.0 * (t > start13) * (t < end13))[s-1] reverse rate constant (Kr): ((50.0 * (t > end13)) * (t < start14))[s-1] user defined (start13): 36500.0[s] user defined (end13): 38000.0[s] user defined (start14): 38500.0[s]
L_5HT_15L_5HT	inj15 EC	MassAction	L_5HT_15L_5HT
		reaction rate (J): ((Kf * L_5HT_15) - (Kr * L_5HT))[uM.s-1] forward rate constant (Kf): (50.0 * (t > start14) * (t < end14))[s-1] reverse rate constant (Kr): (50.0 * (t > end14) * (t < start15))[s-1] user defined (end14): 40000.0[s] user defined (start14): 38500.0[s] user defined (start15): 40500.0[s]
L_5HT_16L_5HT	inj16 EC	MassAction	L_5HT_16L_5HT
		reaction rate (J): ((Kf * L_5HT_16) - (Kr * L_5HT))[uM.s-1] forward rate constant (Kf): (50.0 * (t > start15) * (t < end15))[s-1] reverse rate constant (Kr): (50.0 * (t > end15))[s-1] user defined (end15): 42000.0[s] user defined (start15): 40500.0[s]
ss3_IsoL_ISO	ss_3 EC	MassAction	ss3_IsoL_ISO
		reaction rate (J): ((Kf * ss3_Iso) - (Kr * L_ISO))[uM.s-1] forward rate constant (Kf): (50.0 * (t > start))[s-1] reverse rate constant (Kr): 0.0[s-1] user defined (start): 530.0[s]
L_ISO_1L_ISO	ISO1 EC	MassAction	L_ISO_1L_ISO
		reaction rate (J): ((Kf * L_ISO_1) - (Kr * L_ISO))[uM.s-1] forward rate constant (Kf): (50.0 * (t > start) * (t < end))[s-1] reverse rate constant (Kr): ((50.0 * (t > end)) * (t < start1))[s-1] user defined (start): 10500.0[s] user defined (end): 12000.0[s] user defined (start1): 12500.0[s]
L_ISO_2L_ISO	ISO2 EC	MassAction	L_ISO_2L_ISO
		reaction rate (J): ((Kf * L_ISO_2) - (Kr * L_ISO))[uM.s-1] forward rate constant (Kf): (50.0 * (t > start1) * (t < end1))[s-1] reverse rate constant (Kr): ((50.0 * (t > end1)) * (t < start2))[s-1] user defined (start1): 12500.0[s] user defined (end1): 14000.0[s] user defined (start2): 14500.0[s]
L_ISO_3L_ISO	ISO3 EC	MassAction	L_ISO_3L_ISO
		reaction rate (J): ((Kf * L_ISO_3) - (Kr * L_ISO))[uM.s-1] forward rate constant (Kf): (50.0 * (t > start2) * (t < end2))[s-1] reverse rate constant (Kr): ((50.0 * (t > end2)) * (t < start3))[s-1] user defined (end2): 16000.0[s] user defined (start2): 14500.0[s] user defined (start3): 16500.0[s]
L_ISO_4L_ISO	ISO_4 EC	MassAction	L_ISO_4L_ISO
		reaction rate (J): ((Kf * L_ISO_4) - (Kr * L_ISO))[uM.s-1] forward rate constant (Kf): (50.0 * (t > start3) * (t < end3))[s-1] reverse rate constant (Kr): ((50.0 * (t > end3)) * (t < start4))[s-1] user defined (end3): 18000.0[s] user defined (start3): 16500.0[s] user defined (start4): 18500.0[s]
L_ISO_5L_ISO	ISO_5 EC	MassAction	L_ISO_5L_ISO
		reaction rate (J): ((Kf * L_ISO_5) - (Kr * L_ISO))[uM.s-1] forward rate constant (Kf): (50.0 * (t > start4) * (t < end4))[s-1] reverse rate constant (Kr): ((50.0 * (t > end4)) * (t < start5))[s-1] user defined (end4): 20000.0[s] user defined (start4): 18500.0[s] user defined (start5): 20500.0[s]
L_ISO_6L_ISO	ISO_6 EC	MassAction	L_ISO_6L_ISO
		reaction rate (J): ((Kf * L_ISO_6) - (Kr * L_ISO))[uM.s-1] forward rate constant (Kf): (50.0 * (t > start5) * (t < end5))[s-1] reverse rate constant (Kr): ((50.0 * (t > end5)) * (t < start6))[s-1] user defined (end5): 22000.0[s] user defined (start5): 20500.0[s] user defined (start6): 22500.0[s]
L_ISO_7L_ISO	ISO_7 EC	MassAction	L_ISO_7L_ISO
		reaction rate (J): ((Kf * L_ISO_7) - (Kr * L_ISO))[uM.s-1] forward rate constant (Kf): (50.0 * (t > start6) * (t < end6))[s-1] reverse rate constant (Kr): ((50.0 * (t > end6)) * (t < start7))[s-1] user defined (end6): 24000.0[s] user defined (start6): 22500.0[s] user defined (start7): 24500.0[s]
L_ISO_8L_ISO	ISO_8 EC	MassAction	L_ISO_8L_ISO
		reaction rate (J): ((Kf * L_ISO_8) - (Kr * L_ISO))[uM.s-1] forward rate constant (Kf): (50.0 * (t > start7) * (t < end7))[s-1] reverse rate constant (Kr): ((50.0 * (t > end7)) * (t < start8))[s-1] user defined (end7): 26000.0[s] user defined (start7): 24500.0[s] user defined (start8): 26500.0[s]
L_ISO_9L_ISO	ISO_9 EC	MassAction	L_ISO_9L_ISO
		reaction rate (J): ((Kf * L_ISO_9) - (Kr * L_ISO))[uM.s-1] forward rate constant (Kf): (50.0 * (t > start8) * (t < end8))[s-1] reverse rate constant (Kr): ((50.0 * (t > end8)) * (t < start9))[s-1] user defined (end8): 28000.0[s] user defined (start8): 26500.0[s] user defined (start9): 28500.0[s]
L_ISO_10L_ISO	ISO_10 EC	MassAction	L_ISO_10L_ISO
		reaction rate (J): ((Kf * L_ISO_10) - (Kr * L_ISO))[uM.s-1] forward rate constant (Kf): (50.0 * (t > start9) * (t < end9))[s-1] reverse rate constant (Kr): ((50.0 * (t > end9)) * (t < start10))[s-1] user defined (end9): 30000.0[s] user defined (start9): 28500.0[s] user defined (start10): 30500.0[s]
L_ISO_11L_ISO	ISO_11 EC	MassAction	L_ISO_11L_ISO
		reaction rate (J): ((Kf * L_ISO_11) - (Kr * L_ISO))[uM.s-1] forward rate constant (Kf): (50.0 * (t > start10) * (t < end10))[s-1] reverse rate constant (Kr): ((50.0 * (t > end10)) * (t < start11))[s-1] user defined (end10): 32000.0[s] user defined (start10): 30500.0[s] user defined (start11): 32500.0[s]
L_ISO_12L_ISO	ISO_12 EC	MassAction	L_ISO_12L_ISO
		reaction rate (J): ((Kf * L_ISO_12) - (Kr * L_ISO))[uM.s-1] forward rate constant (Kf): (50.0 * (t > start11) * (t < end11))[s-1] reverse rate constant (Kr): ((50.0 * (t > end11)) * (t < start12))[s-1] user defined (start11): 32500.0[s] user defined (end11): 34000.0[s] user defined (start12): 34500.0[s]
L_ISO_13L_ISO	ISO_13 EC	MassAction	L_ISO_13L_ISO
		reaction rate (J): ((Kf * L_ISO_13) - (Kr * L_ISO))[uM.s-1] forward rate constant (Kf): (50.0 * (t > start12) * (t < end12))[s-1] reverse rate constant (Kr): ((50.0 * (t > end12)) * (t < start13))[s-1] user defined (start12): 34500.0[s] user defined (end12): 36000.0[s] user defined (start13): 36500.0[s]
L_ISO_14L_ISO	ISO_14 EC	MassAction	L_ISO_14L_ISO
		reaction rate (J): ((Kf * L_ISO_14) - (Kr * L_ISO))[uM.s-1] forward rate constant (Kf): (50.0 * (t > start13) * (t < end13))[s-1] reverse rate constant (Kr): ((50.0 * (t > end13)) * (t < start14))[s-1] user defined (start13): 36500.0[s] user defined (end13): 38000.0[s] user defined (start14): 38500.0[s]
L_ISO_15L_ISO	ISO_15 EC	MassAction	L_ISO_15L_ISO
		reaction rate (J): ((Kf * L_ISO_15) - (Kr * L_ISO))[uM.s-1] forward rate constant (Kf): (50.0 * (t > start14) * (t < end14))[s-1] reverse rate constant (Kr): ((50.0 * (t > end14)) * (t < start15))[s-1] user defined (end14): 40000.0[s] user defined (start14): 38500.0[s] user defined (start15): 40500.0[s]
L_ISO_16L_ISO	ISO_16 EC	MassAction	L_ISO_16L_ISO
		reaction rate (J): ((Kf * L_ISO_16) - (Kr * L_ISO))[uM.s-1] forward rate constant (Kf): (50.0 * (t > start15) * (t < end15))[s-1] reverse rate constant (Kr): 0.0[s-1] user defined (start15): 40500.0[s] user defined (end15): 42000.0[s]
ss4_ICII_ICI	ss_4 EC	MassAction	ss4_ICII_ICI
		reaction rate (J): ((Kf * ss4_ICI) - (Kr * I_ICI))[uM.s-1] forward rate constant (Kf): (50.0 * (t > start))[s-1] reverse rate constant (Kr): 0.0[s-1] user defined (start): 575.0[s]

Structures See in Dashboard
Name	Type Electrical (Membrane Polarity)
EC	Compartment (+) (-)

IC	Compartment (+) (-)

PM	Membrane N/A

Species See in Dashboard
Name	Structure	BioNetGen Definition
Gs_GDP_s	PM	Gs(GxP!1,R_Bind!-,).GDP(B_GxP!1,).

Gs_GTP_s	PM	Gs(GxP!1,R_Bind!-,).GTP(B_GxP!1,).

Gs_Empty_s	PM	Gs(GxP!-,R_Bind!-,).

GDP_free	IC	GDP(B_GxP!-,).

GTP_free	IC	GTP(B_GxP!-,).

HTR7_Apo_Inactive_Unbound	PM	HTR7(Gs_Bind!-,State~Inactive!-,L_Bind!-,).

HTR7_L_Active_Unbound	PM	L_5HT(L_Site!1,).HTR7(Gs_Bind!-,State~Active!-,L_Bind!1,).

HTR7_L_Inactive_Unbound	PM	L_5HT(L_Site!1,).HTR7(Gs_Bind!-,State~Inactive!-,L_Bind!1,).

HTR7_L_Active_Gs_GDP	PM	L_5HT(L_Site!1,).HTR7(Gs_Bind!2,State~Active!-,L_Bind!1,).Gs(GxP!3,R_Bind!2,).GDP(B_GxP!3,).

HTR7_L_Active_Gs_Empty	PM	L_5HT(L_Site!1,).HTR7(Gs_Bind!2,State~Active!-,L_Bind!1,).Gs(GxP!-,R_Bind!2,).

HTR7_L_Active_Gs_GTP	PM	L_5HT(L_Site!1,).HTR7(Gs_Bind!2,State~Active!-,L_Bind!1,).Gs(GxP!3,R_Bind!2,).GTP(B_GxP!3,).

HTR7_Apo_Active_Unbound	PM	HTR7(Gs_Bind!-,State~Active!-,L_Bind!-,).

L_5HT	EC	L_5HT(L_Site!-,).

L_5HT_1	EC

L_5HT_2	EC

L_5HT_3	EC

L_5HT_4	EC

L_5HT_5	EC

L_5HT_6	EC

L_5HT_7	EC

L_5HT_8	EC

L_5HT_9	EC

L_5HT_10	EC

L_5HT_11	EC

L_5HT_12	EC

L_5HT_13	EC

ss1_5HT	EC

ss2_MT	EC

I_MT	EC	I_MT(L_Site!-,).

GDP_IC	IC

GTP_IC	IC

L_5HT_14	EC

L_5HT_15	EC

L_5HT_16	EC

L_ISO	EC	Iso(L_Site!-,).

ss3_Iso	EC

B2AR_Apo_Inactive	PM	B2AR(Gs_Bind!-,State~null!-,L_Bind!-,).

G12_Empty_s	PM	G12(GxP!-,R_Bind!-,).

G12_GDP_S	PM	G12(GxP!1,R_Bind!-,).GDP(B_GxP!1,).

GRK_Kras_s	PM	GRK_KRAS(R_Bind!-,).

L_ISO_1	EC

L_ISO_2	EC

L_ISO_3	EC

L_ISO_4	EC

L_ISO_5	EC

L_ISO_6	EC

L_ISO_7	EC

L_ISO_8	EC

L_ISO_9	EC

L_ISO_10	EC

L_ISO_11	EC

L_ISO_12	EC

L_ISO_13	EC

L_ISO_14	EC

L_ISO_15	EC

L_ISO_16	EC

I_ICI	EC	ICI(L_Site!-,).

ss4_ICI	EC

HTR7_null_apo	PM	HTR7(Gs_Bind!-,State~null!-,L_Bind!-,).

Molecules See in Dashboard
Name	Text Annotations	BioNetGen Definition
Gs	Text Annotations	Gs(GxP,R_Bind,)

HTR7	Text Annotations	HTR7(Gs_Bind,State~Inactive~Active~null,L_Bind,)

L_5HT	Text Annotations	L_5HT(L_Site,)

GDP	Text Annotations	GDP(B_GxP,)

GTP	Text Annotations	GTP(B_GxP,)

I_MT	Text Annotations	I_MT(L_Site,)

B2AR	Text Annotations	B2AR(Gs_Bind,State~null~Active,L_Bind,)

Iso	Text Annotations	Iso(L_Site,)

GRK_KRAS	Text Annotations	GRK_KRAS(R_Bind,)

G12	Text Annotations	G12(GxP,R_Bind,)

ICI	Text Annotations	ICI(L_Site,)

Observables See in Dashboard
Name	Type Count	BioNetGen Definition
L_5HT_Total	Molecules Multimolecular	L_5HT(L_Site!?,).

O0_GDP_tot	Molecules Multimolecular	GDP(B_GxP!?,).

O0_GTP_tot	Molecules Multimolecular	GTP(B_GxP!?,).

O0_I_MT_tot	Molecules Multimolecular	I_MT(L_Site!?,).

Gs_GDP_Total	Molecules Multimolecular	Gs(GxP!1,R_Bind!-,).GDP(B_GxP!1,).

Gs_GTP_Total	Molecules Multimolecular	Gs(GxP!1,R_Bind!-,).GTP(B_GxP!1,).

Gs_Empty_Total	Molecules Multimolecular	Gs(GxP!-,R_Bind!-,).

Active_coupled_HTR7complexes_Total	Molecules Multimolecular	HTR7(Gs_Bind!1,State~Active!-,L_Bind!?,).Gs(GxP!?,R_Bind!1,).

Active_HTR7_Total	Molecules Multimolecular	HTR7(Gs_Bind!?,State~Active!-,L_Bind!?,).

Inactive_HTR7_Total	Molecules Multimolecular	HTR7(Gs_Bind!?,State~Inactive!-,L_Bind!?,).

HTR7_Total	Molecules Multimolecular	HTR7(Gs_Bind!?,State!?,L_Bind!?,).

Gs_Total	Molecules Multimolecular	Gs(GxP!?,R_Bind!?,).

Total_HTR7_Gs_Complexes	Molecules Multimolecular	HTR7(Gs_Bind!1,State~Inactive!-,L_Bind!?,).Gs(GxP!?,R_Bind!1,).HTR7(Gs_Bind!1,State~Active!-,L_Bind!?,).Gs(GxP!?,R_Bind!1,).

Inverse_coupled_HTR7complexes_Total	Molecules Multimolecular	HTR7(Gs_Bind!1,State~Inactive!-,L_Bind!?,).Gs(GxP!?,R_Bind!1,).

Inverse_coupled_HTR7_Gs_GDP	Molecules Multimolecular	HTR7(Gs_Bind!1,State~Inactive!-,L_Bind!?,).Gs(GxP!2,R_Bind!1,).GDP(B_GxP!2,).

Inverse_coupled_HTR7_Gs_GTP	Molecules Multimolecular	HTR7(Gs_Bind!1,State~Inactive!-,L_Bind!?,).Gs(GxP!2,R_Bind!1,).GTP(B_GxP!2,).

Inverse_coupled_HTR7_Gs_Empty	Molecules Multimolecular	HTR7(Gs_Bind!1,State~Inactive!-,L_Bind!?,).Gs(GxP!-,R_Bind!1,).

MT_Bound_HTR7_Total	Molecules Multimolecular	I_MT(L_Site!1,).HTR7(Gs_Bind!?,State!?,L_Bind!1,).

B2AR_tot	Molecules Multimolecular	B2AR(Gs_Bind!?,State!?,L_Bind!?,).

Iso_tot	Molecules Multimolecular	Iso(L_Site!?,).

B2AR_Gs_Complexes	Molecules Multimolecular	B2AR(Gs_Bind!1,State~Active!-,L_Bind!?,).Gs(GxP!?,R_Bind!1,).

B2AR_Active	Molecules Multimolecular	B2AR(Gs_Bind!?,State~Active!-,L_Bind!?,).

B2AR_Iso_Bound	Molecules Multimolecular	Iso(L_Site!1,).B2AR(Gs_Bind!?,State!?,L_Bind!1,).

B2AR_G_GDP	Molecules Multimolecular	B2AR(Gs_Bind!2,State~Active!-,L_Bind!?,).Gs(GxP!3,R_Bind!2,).GDP(B_GxP!3,).

B2AR_G_Empty	Molecules Multimolecular	B2AR(Gs_Bind!2,State~Active!-,L_Bind!?,).Gs(GxP!-,R_Bind!2,).

B2AR_G_GTP	Molecules Multimolecular	B2AR(Gs_Bind!2,State~Active!-,L_Bind!?,).Gs(GxP!3,R_Bind!2,).GTP(B_GxP!3,).

ICI_tot	Molecules Multimolecular	ICI(L_Site!?,).

ICI_bound_B2AR	Molecules Multimolecular	ICI(L_Site!1,).B2AR(Gs_Bind!?,State!?,L_Bind!1,).

Active_coupled_HTR7_Gs_GTP	Molecules Multimolecular	HTR7(Gs_Bind!1,State~Active!-,L_Bind!?,).Gs(GxP!2,R_Bind!1,).GTP(B_GxP!2,).

Agonist_bound_HTR7	Molecules Multimolecular	L_5HT(L_Site!1,).HTR7(Gs_Bind!?,State!?,L_Bind!1,).

Applications

Applications See in Dashboard
Name	Math Type	Annotation
Application0	Deterministic (ODE) Compartmental

Application - Application0

Specifications(Species) - Application0 See in Dashboard
Species	Initial Condition	Diffusion Constant
L_5HT	0.0 [uM]	0.0 [um2/s]
L_5HT_1	3.16228E-5 [uM]	0.0 [um2/s]
L_5HT_2	1.0E-4 [uM]	0.0 [um2/s]
L_5HT_3	3.16E-4 [uM]	0.0 [um2/s]
L_5HT_4	0.001 [uM]	0.0 [um2/s]
L_5HT_5	0.003162 [uM]	0.0 [um2/s]
L_5HT_6	0.01 [uM]	0.0 [um2/s]
L_5HT_7	0.031623 [uM]	0.0 [um2/s]
L_5HT_8	0.1 [uM]	0.0 [um2/s]
L_5HT_9	0.31623 [uM]	0.0 [um2/s]
L_5HT_10	1.0 [uM]	0.0 [um2/s]
L_5HT_11	3.162278 [uM]	0.0 [um2/s]
L_5HT_12	10.0 [uM]	0.0 [um2/s]
L_5HT_13	31.62278 [uM]	0.0 [um2/s]
ss1_5HT	1.0 [uM]	0.0 [um2/s]
ss2_MT	100.0 [uM]	0.0 [um2/s]
I_MT	0.0 [uM]	0.0 [um2/s]
L_5HT_14	100.0 [uM]	0.0 [um2/s]
L_5HT_15	316.2278 [uM]	0.0 [um2/s]
L_5HT_16	1000.0 [uM]	0.0 [um2/s]
L_ISO	0.0 [uM]	0.0 [um2/s]
ss3_Iso	1.0 [uM]	0.0 [um2/s]
L_ISO_1	3.16228E-5 [uM]	0.0 [um2/s]
L_ISO_2	1.0E-4 [uM]	0.0 [um2/s]
L_ISO_3	3.16E-4 [uM]	0.0 [um2/s]
L_ISO_4	0.001 [uM]	0.0 [um2/s]
L_ISO_5	0.003162 [uM]	0.0 [um2/s]
L_ISO_6	0.01 [uM]	0.0 [um2/s]
L_ISO_7	0.031623 [uM]	0.0 [um2/s]
L_ISO_8	0.1 [uM]	0.0 [um2/s]
L_ISO_9	0.31623 [uM]	0.0 [um2/s]
L_ISO_10	1.0 [uM]	0.0 [um2/s]
L_ISO_11	3.162278 [uM]	0.0 [um2/s]
L_ISO_12	10.0 [uM]	0.0 [um2/s]
L_ISO_13	31.62278 [uM]	0.0 [um2/s]
L_ISO_14	100.0 [uM]	0.0 [um2/s]
L_ISO_15	316.2278 [uM]	0.0 [um2/s]
L_ISO_16	1000.0 [uM]	0.0 [um2/s]
I_ICI	0.0 [uM]	0.0 [um2/s]
ss4_ICI	8.0 [uM]	0.0 [um2/s]
GDP_free	0.0 [uM]	0.0 [um2/s]
GTP_free	0.0 [uM]	0.0 [um2/s]
GDP_IC	30.0 [uM]	0.0 [um2/s]
GTP_IC	300.0 [uM]	0.0 [um2/s]
Gs_GDP_s	50.0 [uM]	0.0 [um2/s]
Gs_GTP_s	0.0 [uM]	0.0 [um2/s]
Gs_Empty_s	0.0 [uM]	0.0 [um2/s]
HTR7_Apo_Inactive_Unbound	0.0 [uM]	0.0 [um2/s]
HTR7_L_Active_Unbound	0.0 [uM]	0.0 [um2/s]
HTR7_L_Inactive_Unbound	0.0 [uM]	0.0 [um2/s]
HTR7_L_Active_Gs_GDP	0.0 [uM]	0.0 [um2/s]
HTR7_L_Active_Gs_Empty	0.0 [uM]	0.0 [um2/s]
HTR7_L_Active_Gs_GTP	0.0 [uM]	0.0 [um2/s]
HTR7_Apo_Active_Unbound	0.0 [uM]	0.0 [um2/s]
B2AR_Apo_Inactive	0.0 [uM]	0.0 [um2/s]
G12_Empty_s	0.0 [uM]	0.0 [um2/s]
G12_GDP_S	0.0 [uM]	0.0 [um2/s]
GRK_Kras_s	0.0 [uM]	0.0 [um2/s]
HTR7_null_apo	0.5 [uM]	0.0 [um2/s]

Specifications(Reaction) - Application0 See in Dashboard
Name	Reaction Mapping
inj1	included
inj2	included
inj3	included
inj4	included
inj5	included
inj6	included
inj7	included
inj8	included
inj9	included
inj10	included
inj11	included
inj12	included
inj13	included
ss_1	included
ss_2	included
GDP_Inj	included
GTP_Inj	included
inj14	included
inj15	included
inj16	included
ss_3	excluded
ISO1	included
ISO2	included
ISO3	included
ISO_4	included
ISO_5	included
ISO_6	included
ISO_7	included
ISO_8	included
ISO_9	included
ISO_10	included
ISO_11	included
ISO_12	included
ISO_13	included
ISO_14	included
ISO_15	included
ISO_16	included
ss_4	excluded

Simulations - Application0 See in Dashboard
Name	End Time	Output Options
Simulation0	650.0 [s]	OutputTimeStep 0.5

Geometry non-spatial834646333 See in Dashboard
(Origin: 0.0, 0.0, 0.0; Extent: 10.0, 10.0, 10.0[um])
Dimension	Type	Subdomain	Adjacent Subvolumes	Size	Mapped Compartment
	Compartmental	Compartment			PM

Global Parameters

Global Parameters See in Dashboard
Name	Expression