Physiology
Reaction Diagram
Cross-References
Annotations
Reactions
| Reactions | Name | Structure | Kinetics | Depiction |
|---|---|---|---|---|
| L_5HT_1L_5HT | inj1 | EC | MassAction | |
| L_5HT_2L_5HT | inj2 | EC | MassAction | |
| L_5HT_3L_5HT | inj3 | EC | MassAction | |
| L_5HT_4L_5HT | inj4 | EC | MassAction | |
| L_5HT_5L_5HT | inj5 | EC | MassAction | |
| L_5HT_6L_5HT | inj6 | EC | MassAction | |
| L_5HT_7L_5HT | inj7 | EC | MassAction | |
| L_5HT_8L_5HT | inj8 | EC | MassAction | |
| L_5HT_9L_5HT | inj9 | EC | MassAction | |
| L_5HT_10L_5HT | inj10 | EC | MassAction | |
| L_5HT_11L_5HT | inj11 | EC | MassAction | |
| L_5HT_12L_5HT | inj12 | EC | MassAction | |
| L_5HT_13L_5HT | inj13 | EC | MassAction | |
| ss1_5HTL_5HT | ss_1 | EC | MassAction | |
| ss2_MTI_MT | ss_2 | EC | MassAction | |
| GDP_ICGDP_free | GDP_Inj | IC | MassAction | |
| GTP_ICGTP_free | GTP_Inj | IC | MassAction | |
| L_5HT_14L_5HT | inj14 | EC | MassAction | |
| L_5HT_15L_5HT | inj15 | EC | MassAction | |
| L_5HT_16L_5HT | inj16 | EC | MassAction | |
| ss3_IsoL_ISO | ss_3 | EC | MassAction | |
| L_ISO_1L_ISO | ISO1 | EC | MassAction | |
| L_ISO_2L_ISO | ISO2 | EC | MassAction | |
| L_ISO_3L_ISO | ISO3 | EC | MassAction | |
| L_ISO_4L_ISO | ISO_4 | EC | MassAction | |
| L_ISO_5L_ISO | ISO_5 | EC | MassAction | |
| L_ISO_6L_ISO | ISO_6 | EC | MassAction | |
| L_ISO_7L_ISO | ISO_7 | EC | MassAction | |
| L_ISO_8L_ISO | ISO_8 | EC | MassAction | |
| L_ISO_9L_ISO | ISO_9 | EC | MassAction | |
| L_ISO_10L_ISO | ISO_10 | EC | MassAction | |
| L_ISO_11L_ISO | ISO_11 | EC | MassAction | |
| L_ISO_12L_ISO | ISO_12 | EC | MassAction | |
| L_ISO_13L_ISO | ISO_13 | EC | MassAction | |
| L_ISO_14L_ISO | ISO_14 | EC | MassAction | |
| L_ISO_15L_ISO | ISO_15 | EC | MassAction | |
| L_ISO_16L_ISO | ISO_16 | EC | MassAction | |
| ss4_ICII_ICI | ss_4 | EC | MassAction |
inj1 Universal ID's
inj1 Text Annotations
inj2 Universal ID's
inj2 Text Annotations
inj3 Universal ID's
inj3 Text Annotations
inj4 Universal ID's
inj4 Text Annotations
inj5 Universal ID's
inj5 Text Annotations
inj6 Universal ID's
inj6 Text Annotations
inj7 Universal ID's
inj7 Text Annotations
inj8 Universal ID's
inj8 Text Annotations
inj9 Universal ID's
inj9 Text Annotations
inj10 Universal ID's
inj10 Text Annotations
inj11 Universal ID's
inj11 Text Annotations
inj12 Universal ID's
inj12 Text Annotations
inj13 Universal ID's
inj13 Text Annotations
ss_1 Universal ID's
ss_1 Text Annotations
ss_2 Universal ID's
ss_2 Text Annotations
GDP_Inj Universal ID's
GDP_Inj Text Annotations
GTP_Inj Universal ID's
GTP_Inj Text Annotations
inj14 Universal ID's
inj14 Text Annotations
inj15 Universal ID's
inj15 Text Annotations
inj16 Universal ID's
inj16 Text Annotations
ss_3 Universal ID's
ss_3 Text Annotations
ISO1 Universal ID's
ISO1 Text Annotations
ISO2 Universal ID's
ISO2 Text Annotations
ISO3 Universal ID's
ISO3 Text Annotations
ISO_4 Universal ID's
ISO_4 Text Annotations
ISO_5 Universal ID's
ISO_5 Text Annotations
ISO_6 Universal ID's
ISO_6 Text Annotations
ISO_7 Universal ID's
ISO_7 Text Annotations
ISO_8 Universal ID's
ISO_8 Text Annotations
ISO_9 Universal ID's
ISO_9 Text Annotations
ISO_10 Universal ID's
ISO_10 Text Annotations
ISO_11 Universal ID's
ISO_11 Text Annotations
ISO_12 Universal ID's
ISO_12 Text Annotations
ISO_13 Universal ID's
ISO_13 Text Annotations
ISO_14 Universal ID's
ISO_14 Text Annotations
ISO_15 Universal ID's
ISO_15 Text Annotations
ISO_16 Universal ID's
ISO_16 Text Annotations
ss_4 Universal ID's
ss_4 Text Annotations
Expressions for inj1
reaction rate
J
((Kf * L_5HT_1) - (Kr * L_5HT)) [uM.s-1]
forward rate constant
Kf
(50.0 * (t > start) * (t < end)) [s-1]
reverse rate constant
Kr
((50.0 * (t > end)) * (t < start1)) [s-1]
local
start
10500.0 [s]
local
end
12000.0 [s]
local
start1
12500.0 [s]
Expressions for inj2
reaction rate
J
((Kf * L_5HT_2) - (Kr * L_5HT)) [uM.s-1]
forward rate constant
Kf
(50.0 * (t > start1) * (t < end1)) [s-1]
reverse rate constant
Kr
((50.0 * (t > end1)) * (t < start2)) [s-1]
local
start1
12500.0 [s]
local
end1
14000.0 [s]
local
start2
14500.0 [s]
Expressions for inj3
reaction rate
J
((Kf * L_5HT_3) - (Kr * L_5HT)) [uM.s-1]
forward rate constant
Kf
(50.0 * (t > start2) * (t < end2)) [s-1]
reverse rate constant
Kr
((50.0 * (t > end2)) * (t < start3)) [s-1]
local
end2
16000.0 [s]
local
start2
14500.0 [s]
local
start3
16500.0 [s]
Expressions for inj4
reaction rate
J
((Kf * L_5HT_4) - (Kr * L_5HT)) [uM.s-1]
forward rate constant
Kf
(50.0 * (t > start3) * (t < end3)) [s-1]
reverse rate constant
Kr
((50.0 * (t > end3)) * (t < start4)) [s-1]
local
end3
18000.0 [s]
local
start3
16500.0 [s]
local
start4
18500.0 [s]
Expressions for inj5
reaction rate
J
((Kf * L_5HT_5) - (Kr * L_5HT)) [uM.s-1]
forward rate constant
Kf
(50.0 * (t > start4) * (t < end4)) [s-1]
reverse rate constant
Kr
((50.0 * (t > end4)) * (t < start5)) [s-1]
local
end4
20000.0 [s]
local
start4
18500.0 [s]
local
start5
20500.0 [s]
Expressions for inj6
reaction rate
J
((Kf * L_5HT_6) - (Kr * L_5HT)) [uM.s-1]
forward rate constant
Kf
(50.0 * (t > start5) * (t < end5)) [s-1]
reverse rate constant
Kr
((50.0 * (t > end5)) * (t < start6)) [s-1]
local
end5
22000.0 [s]
local
start5
20500.0 [s]
local
start6
22500.0 [s]
Expressions for inj7
reaction rate
J
((Kf * L_5HT_7) - (Kr * L_5HT)) [uM.s-1]
forward rate constant
Kf
(50.0 * (t > start6) * (t < end6)) [s-1]
reverse rate constant
Kr
((50.0 * (t > end6)) * (t < start7)) [s-1]
local
end6
24000.0 [s]
local
start6
22500.0 [s]
local
start7
24500.0 [s]
Expressions for inj8
reaction rate
J
((Kf * L_5HT_8) - (Kr * L_5HT)) [uM.s-1]
forward rate constant
Kf
(50.0 * (t > start7) * (t < end7)) [s-1]
reverse rate constant
Kr
((50.0 * (t > end7)) * (t < start8)) [s-1]
local
end7
26000.0 [s]
local
start7
24500.0 [s]
local
start8
26500.0 [s]
Expressions for inj9
reaction rate
J
((Kf * L_5HT_9) - (Kr * L_5HT)) [uM.s-1]
forward rate constant
Kf
(50.0 * (t > start8) * (t < end8)) [s-1]
reverse rate constant
Kr
((50.0 * (t > end8)) * (t < start9)) [s-1]
local
end8
28000.0 [s]
local
start8
26500.0 [s]
local
start9
28500.0 [s]
Expressions for inj10
reaction rate
J
((Kf * L_5HT_10) - (Kr * L_5HT)) [uM.s-1]
forward rate constant
Kf
(50.0 * (t > start9) * (t < end9)) [s-1]
reverse rate constant
Kr
((50.0 * (t > end9)) * (t < start10)) [s-1]
local
end9
30000.0 [s]
local
start9
28500.0 [s]
local
start10
30500.0 [s]
Expressions for inj11
reaction rate
J
((Kf * L_5HT_11) - (Kr * L_5HT)) [uM.s-1]
forward rate constant
Kf
(50.0 * (t > start10) * (t < end10)) [s-1]
reverse rate constant
Kr
((50.0 * (t > end10)) * (t < start11)) [s-1]
local
end10
32000.0 [s]
local
start10
30500.0 [s]
local
start11
32500.0 [s]
Expressions for inj12
reaction rate
J
((Kf * L_5HT_12) - (Kr * L_5HT)) [uM.s-1]
forward rate constant
Kf
(50.0 * (t > start11) * (t < end11)) [s-1]
reverse rate constant
Kr
((50.0 * (t > end11)) * (t < start12)) [s-1]
local
start11
32500.0 [s]
local
end11
34000.0 [s]
local
start12
34500.0 [s]
Expressions for inj13
reaction rate
J
((Kf * L_5HT_13) - (Kr * L_5HT)) [uM.s-1]
forward rate constant
Kf
(50.0 * (t > start12) * (t < end12)) [s-1]
reverse rate constant
Kr
((50.0 * (t > end12)) * (t < start13)) [s-1]
local
start12
34500.0 [s]
local
end12
36000.0 [s]
local
start13
36500.0 [s]
Expressions for ss_1
reaction rate
J
((Kf * ss1_5HT) - (Kr * L_5HT)) [uM.s-1]
forward rate constant
Kf
(50.0 * (t > start) * (t < end)) [s-1]
reverse rate constant
Kr
(50.0 * (t > end)) [s-1]
local
end
2300.0 [s]
local
start
530.0 [s]
Expressions for ss_2
reaction rate
J
((Kf * ss2_MT) - (Kr * I_MT)) [uM.s-1]
forward rate constant
Kf
(50.0 * (t > start)) [s-1]
reverse rate constant
Kr
0.0 [s-1]
local
start
575.0 [s]
Expressions for GDP_Inj
reaction rate
J
((Kf * GDP_IC) - (Kr * GDP_free)) [uM.s-1]
forward rate constant
Kf
(50.0 * (t > start)) [s-1]
reverse rate constant
Kr
0.0 [s-1]
local
start
0.0 [s]
Expressions for GTP_Inj
reaction rate
J
((Kf * GTP_IC) - (Kr * GTP_free)) [uM.s-1]
forward rate constant
Kf
(50.0 * (t > start)) [s-1]
reverse rate constant
Kr
0.0 [s-1]
local
start
0.0 [s]
Expressions for inj14
reaction rate
J
((Kf * L_5HT_14) - (Kr * L_5HT)) [uM.s-1]
forward rate constant
Kf
(50.0 * (t > start13) * (t < end13)) [s-1]
reverse rate constant
Kr
((50.0 * (t > end13)) * (t < start14)) [s-1]
local
start13
36500.0 [s]
local
end13
38000.0 [s]
local
start14
38500.0 [s]
Expressions for inj15
reaction rate
J
((Kf * L_5HT_15) - (Kr * L_5HT)) [uM.s-1]
forward rate constant
Kf
(50.0 * (t > start14) * (t < end14)) [s-1]
reverse rate constant
Kr
(50.0 * (t > end14) * (t < start15)) [s-1]
local
end14
40000.0 [s]
local
start14
38500.0 [s]
local
start15
40500.0 [s]
Expressions for inj16
reaction rate
J
((Kf * L_5HT_16) - (Kr * L_5HT)) [uM.s-1]
forward rate constant
Kf
(50.0 * (t > start15) * (t < end15)) [s-1]
reverse rate constant
Kr
(50.0 * (t > end15)) [s-1]
local
end15
42000.0 [s]
local
start15
40500.0 [s]
Expressions for ss_3
reaction rate
J
((Kf * ss3_Iso) - (Kr * L_ISO)) [uM.s-1]
forward rate constant
Kf
(50.0 * (t > start)) [s-1]
reverse rate constant
Kr
0.0 [s-1]
local
start
530.0 [s]
Expressions for ISO1
reaction rate
J
((Kf * L_ISO_1) - (Kr * L_ISO)) [uM.s-1]
forward rate constant
Kf
(50.0 * (t > start) * (t < end)) [s-1]
reverse rate constant
Kr
((50.0 * (t > end)) * (t < start1)) [s-1]
local
start
10500.0 [s]
local
end
12000.0 [s]
local
start1
12500.0 [s]
Expressions for ISO2
reaction rate
J
((Kf * L_ISO_2) - (Kr * L_ISO)) [uM.s-1]
forward rate constant
Kf
(50.0 * (t > start1) * (t < end1)) [s-1]
reverse rate constant
Kr
((50.0 * (t > end1)) * (t < start2)) [s-1]
local
start1
12500.0 [s]
local
end1
14000.0 [s]
local
start2
14500.0 [s]
Expressions for ISO3
reaction rate
J
((Kf * L_ISO_3) - (Kr * L_ISO)) [uM.s-1]
forward rate constant
Kf
(50.0 * (t > start2) * (t < end2)) [s-1]
reverse rate constant
Kr
((50.0 * (t > end2)) * (t < start3)) [s-1]
local
end2
16000.0 [s]
local
start2
14500.0 [s]
local
start3
16500.0 [s]
Expressions for ISO_4
reaction rate
J
((Kf * L_ISO_4) - (Kr * L_ISO)) [uM.s-1]
forward rate constant
Kf
(50.0 * (t > start3) * (t < end3)) [s-1]
reverse rate constant
Kr
((50.0 * (t > end3)) * (t < start4)) [s-1]
local
end3
18000.0 [s]
local
start3
16500.0 [s]
local
start4
18500.0 [s]
Expressions for ISO_5
reaction rate
J
((Kf * L_ISO_5) - (Kr * L_ISO)) [uM.s-1]
forward rate constant
Kf
(50.0 * (t > start4) * (t < end4)) [s-1]
reverse rate constant
Kr
((50.0 * (t > end4)) * (t < start5)) [s-1]
local
end4
20000.0 [s]
local
start4
18500.0 [s]
local
start5
20500.0 [s]
Expressions for ISO_6
reaction rate
J
((Kf * L_ISO_6) - (Kr * L_ISO)) [uM.s-1]
forward rate constant
Kf
(50.0 * (t > start5) * (t < end5)) [s-1]
reverse rate constant
Kr
((50.0 * (t > end5)) * (t < start6)) [s-1]
local
end5
22000.0 [s]
local
start5
20500.0 [s]
local
start6
22500.0 [s]
Expressions for ISO_7
reaction rate
J
((Kf * L_ISO_7) - (Kr * L_ISO)) [uM.s-1]
forward rate constant
Kf
(50.0 * (t > start6) * (t < end6)) [s-1]
reverse rate constant
Kr
((50.0 * (t > end6)) * (t < start7)) [s-1]
local
end6
24000.0 [s]
local
start6
22500.0 [s]
local
start7
24500.0 [s]
Expressions for ISO_8
reaction rate
J
((Kf * L_ISO_8) - (Kr * L_ISO)) [uM.s-1]
forward rate constant
Kf
(50.0 * (t > start7) * (t < end7)) [s-1]
reverse rate constant
Kr
((50.0 * (t > end7)) * (t < start8)) [s-1]
local
end7
26000.0 [s]
local
start7
24500.0 [s]
local
start8
26500.0 [s]
Expressions for ISO_9
reaction rate
J
((Kf * L_ISO_9) - (Kr * L_ISO)) [uM.s-1]
forward rate constant
Kf
(50.0 * (t > start8) * (t < end8)) [s-1]
reverse rate constant
Kr
((50.0 * (t > end8)) * (t < start9)) [s-1]
local
end8
28000.0 [s]
local
start8
26500.0 [s]
local
start9
28500.0 [s]
Expressions for ISO_10
reaction rate
J
((Kf * L_ISO_10) - (Kr * L_ISO)) [uM.s-1]
forward rate constant
Kf
(50.0 * (t > start9) * (t < end9)) [s-1]
reverse rate constant
Kr
((50.0 * (t > end9)) * (t < start10)) [s-1]
local
end9
30000.0 [s]
local
start9
28500.0 [s]
local
start10
30500.0 [s]
Expressions for ISO_11
reaction rate
J
((Kf * L_ISO_11) - (Kr * L_ISO)) [uM.s-1]
forward rate constant
Kf
(50.0 * (t > start10) * (t < end10)) [s-1]
reverse rate constant
Kr
((50.0 * (t > end10)) * (t < start11)) [s-1]
local
end10
32000.0 [s]
local
start10
30500.0 [s]
local
start11
32500.0 [s]
Expressions for ISO_12
reaction rate
J
((Kf * L_ISO_12) - (Kr * L_ISO)) [uM.s-1]
forward rate constant
Kf
(50.0 * (t > start11) * (t < end11)) [s-1]
reverse rate constant
Kr
((50.0 * (t > end11)) * (t < start12)) [s-1]
local
start11
32500.0 [s]
local
end11
34000.0 [s]
local
start12
34500.0 [s]
Expressions for ISO_13
reaction rate
J
((Kf * L_ISO_13) - (Kr * L_ISO)) [uM.s-1]
forward rate constant
Kf
(50.0 * (t > start12) * (t < end12)) [s-1]
reverse rate constant
Kr
((50.0 * (t > end12)) * (t < start13)) [s-1]
local
start12
34500.0 [s]
local
end12
36000.0 [s]
local
start13
36500.0 [s]
Expressions for ISO_14
reaction rate
J
((Kf * L_ISO_14) - (Kr * L_ISO)) [uM.s-1]
forward rate constant
Kf
(50.0 * (t > start13) * (t < end13)) [s-1]
reverse rate constant
Kr
((50.0 * (t > end13)) * (t < start14)) [s-1]
local
start13
36500.0 [s]
local
end13
38000.0 [s]
local
start14
38500.0 [s]
Expressions for ISO_15
reaction rate
J
((Kf * L_ISO_15) - (Kr * L_ISO)) [uM.s-1]
forward rate constant
Kf
(50.0 * (t > start14) * (t < end14)) [s-1]
reverse rate constant
Kr
((50.0 * (t > end14)) * (t < start15)) [s-1]
local
end14
40000.0 [s]
local
start14
38500.0 [s]
local
start15
40500.0 [s]
Expressions for ISO_16
reaction rate
J
((Kf * L_ISO_16) - (Kr * L_ISO)) [uM.s-1]
forward rate constant
Kf
(50.0 * (t > start15) * (t < end15)) [s-1]
reverse rate constant
Kr
0.0 [s-1]
local
start15
40500.0 [s]
local
end15
42000.0 [s]
Expressions for ss_4
reaction rate
J
((Kf * ss4_ICI) - (Kr * I_ICI)) [uM.s-1]
forward rate constant
Kf
(50.0 * (t > start)) [s-1]
reverse rate constant
Kr
0.0 [s-1]
local
start
575.0 [s]
Structures
PM Universal ID's
PM Text Annotations
EC Universal ID's
EC Text Annotations
IC Universal ID's
IC Text Annotations
Species
| Name | Structure | BioNetGen Definition | Depiction |
|---|---|---|---|
| Gs_GDP_s | PM | Gs(GxP!1,R_Bind!-,).GDP(B_GxP!1,). | |
| Gs_GTP_s | PM | Gs(GxP!1,R_Bind!-,).GTP(B_GxP!1,). | |
| Gs_Empty_s | PM | Gs(GxP!-,R_Bind!-,). | |
| GDP_free | IC | GDP(B_GxP!-,). | |
| GTP_free | IC | GTP(B_GxP!-,). | |
| HTR7_Apo_Inactive_Unbound | PM | HTR7(Gs_Bind!-,State~Inactive!-,L_Bind!-,). | |
| HTR7_L_Active_Unbound | PM | L_5HT(L_Site!1,).HTR7(Gs_Bind!-,State~Active!-,L_Bind!1,). | |
| HTR7_L_Inactive_Unbound | PM | L_5HT(L_Site!1,).HTR7(Gs_Bind!-,State~Inactive!-,L_Bind!1,). | |
| HTR7_L_Active_Gs_GDP | PM | L_5HT(L_Site!1,).HTR7(Gs_Bind!2,State~Active!-,L_Bind!1,).Gs(GxP!3,R_Bind!2,).GDP(B_GxP!3,). | |
| HTR7_L_Active_Gs_Empty | PM | L_5HT(L_Site!1,).HTR7(Gs_Bind!2,State~Active!-,L_Bind!1,).Gs(GxP!-,R_Bind!2,). | |
| HTR7_L_Active_Gs_GTP | PM | L_5HT(L_Site!1,).HTR7(Gs_Bind!2,State~Active!-,L_Bind!1,).Gs(GxP!3,R_Bind!2,).GTP(B_GxP!3,). | |
| HTR7_Apo_Active_Unbound | PM | HTR7(Gs_Bind!-,State~Active!-,L_Bind!-,). | |
| L_5HT | EC | L_5HT(L_Site!-,). | |
| L_5HT_1 | EC | ||
| L_5HT_2 | EC | ||
| L_5HT_3 | EC | ||
| L_5HT_4 | EC | ||
| L_5HT_5 | EC | ||
| L_5HT_6 | EC | ||
| L_5HT_7 | EC | ||
| L_5HT_8 | EC | ||
| L_5HT_9 | EC | ||
| L_5HT_10 | EC | ||
| L_5HT_11 | EC | ||
| L_5HT_12 | EC | ||
| L_5HT_13 | EC | ||
| ss1_5HT | EC | ||
| ss2_MT | EC | ||
| I_MT | EC | I_MT(L_Site!-,). | |
| GDP_IC | IC | ||
| GTP_IC | IC | ||
| L_5HT_14 | EC | ||
| L_5HT_15 | EC | ||
| L_5HT_16 | EC | ||
| L_ISO | EC | Iso(L_Site!-,). | |
| ss3_Iso | EC | ||
| B2AR_Apo_Inactive | PM | B2AR(Gs_Bind!-,State~null!-,L_Bind!-,). | |
| G12_Empty_s | PM | G12(GxP!-,R_Bind!-,). | |
| G12_GDP_S | PM | G12(GxP!1,R_Bind!-,).GDP(B_GxP!1,). | |
| GRK_Kras_s | PM | GRK_KRAS(R_Bind!-,). | |
| L_ISO_1 | EC | ||
| L_ISO_2 | EC | ||
| L_ISO_3 | EC | ||
| L_ISO_4 | EC | ||
| L_ISO_5 | EC | ||
| L_ISO_6 | EC | ||
| L_ISO_7 | EC | ||
| L_ISO_8 | EC | ||
| L_ISO_9 | EC | ||
| L_ISO_10 | EC | ||
| L_ISO_11 | EC | ||
| L_ISO_12 | EC | ||
| L_ISO_13 | EC | ||
| L_ISO_14 | EC | ||
| L_ISO_15 | EC | ||
| L_ISO_16 | EC | ||
| I_ICI | EC | ICI(L_Site!-,). | |
| ss4_ICI | EC | ||
| HTR7_null_apo | PM | HTR7(Gs_Bind!-,State~null!-,L_Bind!-,). |
Gs_GDP_s Universal ID's
Gs_GDP_s Text Annotations
Gs_GTP_s Universal ID's
Gs_GTP_s Text Annotations
Gs_Empty_s Universal ID's
Gs_Empty_s Text Annotations
GDP_free Universal ID's
GDP_free Text Annotations
GTP_free Universal ID's
GTP_free Text Annotations
HTR7_Apo_Inactive_Unbound Universal ID's
HTR7_Apo_Inactive_Unbound Text Annotations
HTR7_L_Active_Unbound Universal ID's
HTR7_L_Active_Unbound Text Annotations
HTR7_L_Inactive_Unbound Universal ID's
HTR7_L_Inactive_Unbound Text Annotations
HTR7_L_Active_Gs_GDP Universal ID's
HTR7_L_Active_Gs_GDP Text Annotations
HTR7_L_Active_Gs_Empty Universal ID's
HTR7_L_Active_Gs_Empty Text Annotations
HTR7_L_Active_Gs_GTP Universal ID's
HTR7_L_Active_Gs_GTP Text Annotations
HTR7_Apo_Active_Unbound Universal ID's
HTR7_Apo_Active_Unbound Text Annotations
L_5HT Universal ID's
L_5HT Text Annotations
L_5HT_1 Universal ID's
L_5HT_1 Text Annotations
L_5HT_2 Universal ID's
L_5HT_2 Text Annotations
L_5HT_3 Universal ID's
L_5HT_3 Text Annotations
L_5HT_4 Universal ID's
L_5HT_4 Text Annotations
L_5HT_5 Universal ID's
L_5HT_5 Text Annotations
L_5HT_6 Universal ID's
L_5HT_6 Text Annotations
L_5HT_7 Universal ID's
L_5HT_7 Text Annotations
L_5HT_8 Universal ID's
L_5HT_8 Text Annotations
L_5HT_9 Universal ID's
L_5HT_9 Text Annotations
L_5HT_10 Universal ID's
L_5HT_10 Text Annotations
L_5HT_11 Universal ID's
L_5HT_11 Text Annotations
L_5HT_12 Universal ID's
L_5HT_12 Text Annotations
L_5HT_13 Universal ID's
L_5HT_13 Text Annotations
ss1_5HT Universal ID's
ss1_5HT Text Annotations
ss2_MT Universal ID's
ss2_MT Text Annotations
I_MT Universal ID's
I_MT Text Annotations
GDP_IC Universal ID's
GDP_IC Text Annotations
GTP_IC Universal ID's
GTP_IC Text Annotations
L_5HT_14 Universal ID's
L_5HT_14 Text Annotations
L_5HT_15 Universal ID's
L_5HT_15 Text Annotations
L_5HT_16 Universal ID's
L_5HT_16 Text Annotations
L_ISO Universal ID's
L_ISO Text Annotations
ss3_Iso Universal ID's
ss3_Iso Text Annotations
B2AR_Apo_Inactive Universal ID's
B2AR_Apo_Inactive Text Annotations
G12_Empty_s Universal ID's
G12_Empty_s Text Annotations
G12_GDP_S Universal ID's
G12_GDP_S Text Annotations
GRK_Kras_s Universal ID's
GRK_Kras_s Text Annotations
L_ISO_1 Universal ID's
L_ISO_1 Text Annotations
L_ISO_2 Universal ID's
L_ISO_2 Text Annotations
L_ISO_3 Universal ID's
L_ISO_3 Text Annotations
L_ISO_4 Universal ID's
L_ISO_4 Text Annotations
L_ISO_5 Universal ID's
L_ISO_5 Text Annotations
L_ISO_6 Universal ID's
L_ISO_6 Text Annotations
L_ISO_7 Universal ID's
L_ISO_7 Text Annotations
L_ISO_8 Universal ID's
L_ISO_8 Text Annotations
L_ISO_9 Universal ID's
L_ISO_9 Text Annotations
L_ISO_10 Universal ID's
L_ISO_10 Text Annotations
L_ISO_11 Universal ID's
L_ISO_11 Text Annotations
L_ISO_12 Universal ID's
L_ISO_12 Text Annotations
L_ISO_13 Universal ID's
L_ISO_13 Text Annotations
L_ISO_14 Universal ID's
L_ISO_14 Text Annotations
L_ISO_15 Universal ID's
L_ISO_15 Text Annotations
L_ISO_16 Universal ID's
L_ISO_16 Text Annotations
I_ICI Universal ID's
I_ICI Text Annotations
ss4_ICI Universal ID's
ss4_ICI Text Annotations
HTR7_null_apo Universal ID's
HTR7_null_apo Text Annotations
Molecules
| Name | BioNetGen Definition | DEPICTION |
|---|---|---|
| Gs | Gs(GxP,R_Bind,) | |
| HTR7 | HTR7(Gs_Bind,State~Inactive~Active~null,L_Bind,) | |
| L_5HT | L_5HT(L_Site,) | |
| GDP | GDP(B_GxP,) | |
| GTP | GTP(B_GxP,) | |
| I_MT | I_MT(L_Site,) | |
| B2AR | B2AR(Gs_Bind,State~null~Active,L_Bind,) | |
| Iso | Iso(L_Site,) | |
| GRK_KRAS | GRK_KRAS(R_Bind,) | |
| G12 | G12(GxP,R_Bind,) | |
| ICI | ICI(L_Site,) |
Gs Universal ID's
Gs Text Annotations
HTR7 Universal ID's
HTR7 Text Annotations
L_5HT Universal ID's
L_5HT Text Annotations
GDP Universal ID's
GDP Text Annotations
GTP Universal ID's
GTP Text Annotations
I_MT Universal ID's
I_MT Text Annotations
B2AR Universal ID's
B2AR Text Annotations
Iso Universal ID's
Iso Text Annotations
GRK_KRAS Universal ID's
GRK_KRAS Text Annotations
G12 Universal ID's
G12 Text Annotations
ICI Universal ID's
ICI Text Annotations
Observables
| Name | Structure | Count | BNGL Definition | Sequence Type | DEPICTION | |||
|---|---|---|---|---|---|---|---|---|
| L_5HT_Total | EC | Molecules | L_5HT(L_Site!?,). | Multimolecular | ||||
| O0_GDP_tot | EC | Molecules | GDP(B_GxP!?,). | Multimolecular | ||||
| O0_GTP_tot | EC | Molecules | GTP(B_GxP!?,). | Multimolecular | ||||
| O0_I_MT_tot | EC | Molecules | I_MT(L_Site!?,). | Multimolecular | ||||
| Gs_GDP_Total | PM | Molecules | Gs(GxP!1,R_Bind!-,). | GDP(B_GxP!1,). | Multimolecular | |||
| Gs_GTP_Total | PM | Molecules | Gs(GxP!1,R_Bind!-,). | GTP(B_GxP!1,). | Multimolecular | |||
| Gs_Empty_Total | PM | Molecules | Gs(GxP!-,R_Bind!-,). | Multimolecular | ||||
| Active_coupled_HTR7complexes_Total | PM | Molecules | HTR7(Gs_Bind!1,State~Active!-,L_Bind!?,). | Gs(GxP!?,R_Bind!1,). | Multimolecular | |||
| Active_HTR7_Total | PM | Molecules | HTR7(Gs_Bind!?,State~Active!-,L_Bind!?,). | Multimolecular | ||||
| Inactive_HTR7_Total | PM | Molecules | HTR7(Gs_Bind!?,State~Inactive!-,L_Bind!?,). | Multimolecular | ||||
| HTR7_Total | PM | Molecules | HTR7(Gs_Bind!?,State!?,L_Bind!?,). | Multimolecular | ||||
| Gs_Total | PM | Molecules | Gs(GxP!?,R_Bind!?,). | Multimolecular | ||||
| Total_HTR7_Gs_Complexes | PM | Molecules | HTR7(Gs_Bind!1,State~Inactive!-,L_Bind!?,). | Gs(GxP!?,R_Bind!1,). | HTR7(Gs_Bind!1,State~Active!-,L_Bind!?,). | Gs(GxP!?,R_Bind!1,). | Multimolecular | |
| Inverse_coupled_HTR7complexes_Total | PM | Molecules | HTR7(Gs_Bind!1,State~Inactive!-,L_Bind!?,). | Gs(GxP!?,R_Bind!1,). | Multimolecular | |||
| Inverse_coupled_HTR7_Gs_GDP | PM | Molecules | HTR7(Gs_Bind!1,State~Inactive!-,L_Bind!?,). | Gs(GxP!2,R_Bind!1,). | GDP(B_GxP!2,). | Multimolecular | ||
| Inverse_coupled_HTR7_Gs_GTP | PM | Molecules | HTR7(Gs_Bind!1,State~Inactive!-,L_Bind!?,). | Gs(GxP!2,R_Bind!1,). | GTP(B_GxP!2,). | Multimolecular | ||
| Inverse_coupled_HTR7_Gs_Empty | PM | Molecules | HTR7(Gs_Bind!1,State~Inactive!-,L_Bind!?,). | Gs(GxP!-,R_Bind!1,). | Multimolecular | |||
| MT_Bound_HTR7_Total | PM | Molecules | I_MT(L_Site!1,). | HTR7(Gs_Bind!?,State!?,L_Bind!1,). | Multimolecular | |||
| B2AR_tot | EC | Molecules | B2AR(Gs_Bind!?,State!?,L_Bind!?,). | Multimolecular | ||||
| Iso_tot | EC | Molecules | Iso(L_Site!?,). | Multimolecular | ||||
| B2AR_Gs_Complexes | PM | Molecules | B2AR(Gs_Bind!1,State~Active!-,L_Bind!?,). | Gs(GxP!?,R_Bind!1,). | Multimolecular | |||
| B2AR_Active | PM | Molecules | B2AR(Gs_Bind!?,State~Active!-,L_Bind!?,). | Multimolecular | ||||
| B2AR_Iso_Bound | PM | Molecules | Iso(L_Site!1,). | B2AR(Gs_Bind!?,State!?,L_Bind!1,). | Multimolecular | |||
| B2AR_G_GDP | PM | Molecules | B2AR(Gs_Bind!2,State~Active!-,L_Bind!?,). | Gs(GxP!3,R_Bind!2,). | GDP(B_GxP!3,). | Multimolecular | ||
| B2AR_G_Empty | PM | Molecules | B2AR(Gs_Bind!2,State~Active!-,L_Bind!?,). | Gs(GxP!-,R_Bind!2,). | Multimolecular | |||
| B2AR_G_GTP | PM | Molecules | B2AR(Gs_Bind!2,State~Active!-,L_Bind!?,). | Gs(GxP!3,R_Bind!2,). | GTP(B_GxP!3,). | Multimolecular | ||
| ICI_tot | EC | Molecules | ICI(L_Site!?,). | Multimolecular | ||||
| ICI_bound_B2AR | PM | Molecules | ICI(L_Site!1,). | B2AR(Gs_Bind!?,State!?,L_Bind!1,). | Multimolecular | |||
| Active_coupled_HTR7_Gs_GTP | PM | Molecules | HTR7(Gs_Bind!1,State~Active!-,L_Bind!?,). | Gs(GxP!2,R_Bind!1,). | GTP(B_GxP!2,). | Multimolecular | ||
| Agonist_bound_HTR7 | PM | Molecules | L_5HT(L_Site!1,). | HTR7(Gs_Bind!?,State!?,L_Bind!1,). | Multimolecular |
L_5HT_Total Universal ID's
L_5HT_Total Text Annotations
O0_GDP_tot Universal ID's
O0_GDP_tot Text Annotations
O0_GTP_tot Universal ID's
O0_GTP_tot Text Annotations
O0_I_MT_tot Universal ID's
O0_I_MT_tot Text Annotations
Gs_GDP_Total Universal ID's
Gs_GDP_Total Text Annotations
Gs_GTP_Total Universal ID's
Gs_GTP_Total Text Annotations
Gs_Empty_Total Universal ID's
Gs_Empty_Total Text Annotations
Active_coupled_HTR7complexes_Total Universal ID's
Active_coupled_HTR7complexes_Total Text Annotations
Active_HTR7_Total Universal ID's
Active_HTR7_Total Text Annotations
Inactive_HTR7_Total Universal ID's
Inactive_HTR7_Total Text Annotations
HTR7_Total Universal ID's
HTR7_Total Text Annotations
Gs_Total Universal ID's
Gs_Total Text Annotations
Total_HTR7_Gs_Complexes Universal ID's
Total_HTR7_Gs_Complexes Text Annotations
Inverse_coupled_HTR7complexes_Total Universal ID's
Inverse_coupled_HTR7complexes_Total Text Annotations
Inverse_coupled_HTR7_Gs_GDP Universal ID's
Inverse_coupled_HTR7_Gs_GDP Text Annotations
Inverse_coupled_HTR7_Gs_GTP Universal ID's
Inverse_coupled_HTR7_Gs_GTP Text Annotations
Inverse_coupled_HTR7_Gs_Empty Universal ID's
Inverse_coupled_HTR7_Gs_Empty Text Annotations
MT_Bound_HTR7_Total Universal ID's
MT_Bound_HTR7_Total Text Annotations
B2AR_tot Universal ID's
B2AR_tot Text Annotations
Iso_tot Universal ID's
Iso_tot Text Annotations
B2AR_Gs_Complexes Universal ID's
B2AR_Gs_Complexes Text Annotations
B2AR_Active Universal ID's
B2AR_Active Text Annotations
B2AR_Iso_Bound Universal ID's
B2AR_Iso_Bound Text Annotations
B2AR_G_GDP Universal ID's
B2AR_G_GDP Text Annotations
B2AR_G_Empty Universal ID's
B2AR_G_Empty Text Annotations
B2AR_G_GTP Universal ID's
B2AR_G_GTP Text Annotations
ICI_tot Universal ID's
ICI_tot Text Annotations
ICI_bound_B2AR Universal ID's
ICI_bound_B2AR Text Annotations
Active_coupled_HTR7_Gs_GTP Universal ID's
Active_coupled_HTR7_Gs_GTP Text Annotations
Agonist_bound_HTR7 Universal ID's
Agonist_bound_HTR7 Text Annotations
Applications
| Name | Properties | Math Type | Annotation |
|---|---|---|---|
| Application0 |
Specs -
Species Specs - Reaction Simulations |
Deterministic (ODE) Compartmental |
Application0 Universal ID's
Application0 Text Annotations
Specifications (Species) - Application0 go to Simulations
| Species | Initial Condition | Diffusion Constant | Structure |
|---|---|---|---|
| L_5HT | 0.0 [uM] | 0.0 [um2/s] | EC |
| L_5HT_1 | 3.16228E-5 [uM] | 0.0 [um2/s] | EC |
| L_5HT_2 | 1.0E-4 [uM] | 0.0 [um2/s] | EC |
| L_5HT_3 | 3.16E-4 [uM] | 0.0 [um2/s] | EC |
| L_5HT_4 | 0.001 [uM] | 0.0 [um2/s] | EC |
| L_5HT_5 | 0.003162 [uM] | 0.0 [um2/s] | EC |
| L_5HT_6 | 0.01 [uM] | 0.0 [um2/s] | EC |
| L_5HT_7 | 0.031623 [uM] | 0.0 [um2/s] | EC |
| L_5HT_8 | 0.1 [uM] | 0.0 [um2/s] | EC |
| L_5HT_9 | 0.31623 [uM] | 0.0 [um2/s] | EC |
| L_5HT_10 | 1.0 [uM] | 0.0 [um2/s] | EC |
| L_5HT_11 | 3.162278 [uM] | 0.0 [um2/s] | EC |
| L_5HT_12 | 10.0 [uM] | 0.0 [um2/s] | EC |
| L_5HT_13 | 31.62278 [uM] | 0.0 [um2/s] | EC |
| ss1_5HT | 1.0 [uM] | 0.0 [um2/s] | EC |
| ss2_MT | 100.0 [uM] | 0.0 [um2/s] | EC |
| I_MT | 0.0 [uM] | 0.0 [um2/s] | EC |
| L_5HT_14 | 100.0 [uM] | 0.0 [um2/s] | EC |
| L_5HT_15 | 316.2278 [uM] | 0.0 [um2/s] | EC |
| L_5HT_16 | 1000.0 [uM] | 0.0 [um2/s] | EC |
| L_ISO | 0.0 [uM] | 0.0 [um2/s] | EC |
| ss3_Iso | 1.0 [uM] | 0.0 [um2/s] | EC |
| L_ISO_1 | 3.16228E-5 [uM] | 0.0 [um2/s] | EC |
| L_ISO_2 | 1.0E-4 [uM] | 0.0 [um2/s] | EC |
| L_ISO_3 | 3.16E-4 [uM] | 0.0 [um2/s] | EC |
| L_ISO_4 | 0.001 [uM] | 0.0 [um2/s] | EC |
| L_ISO_5 | 0.003162 [uM] | 0.0 [um2/s] | EC |
| L_ISO_6 | 0.01 [uM] | 0.0 [um2/s] | EC |
| L_ISO_7 | 0.031623 [uM] | 0.0 [um2/s] | EC |
| L_ISO_8 | 0.1 [uM] | 0.0 [um2/s] | EC |
| L_ISO_9 | 0.31623 [uM] | 0.0 [um2/s] | EC |
| L_ISO_10 | 1.0 [uM] | 0.0 [um2/s] | EC |
| L_ISO_11 | 3.162278 [uM] | 0.0 [um2/s] | EC |
| L_ISO_12 | 10.0 [uM] | 0.0 [um2/s] | EC |
| L_ISO_13 | 31.62278 [uM] | 0.0 [um2/s] | EC |
| L_ISO_14 | 100.0 [uM] | 0.0 [um2/s] | EC |
| L_ISO_15 | 316.2278 [uM] | 0.0 [um2/s] | EC |
| L_ISO_16 | 1000.0 [uM] | 0.0 [um2/s] | EC |
| I_ICI | 0.0 [uM] | 0.0 [um2/s] | EC |
| ss4_ICI | 8.0 [uM] | 0.0 [um2/s] | EC |
| GDP_free | 0.0 [uM] | 0.0 [um2/s] | IC |
| GTP_free | 0.0 [uM] | 0.0 [um2/s] | IC |
| GDP_IC | 30.0 [uM] | 0.0 [um2/s] | IC |
| GTP_IC | 300.0 [uM] | 0.0 [um2/s] | IC |
| Gs_GDP_s | 50.0 [uM] | 0.0 [um2/s] | PM |
| Gs_GTP_s | 0.0 [uM] | 0.0 [um2/s] | PM |
| Gs_Empty_s | 0.0 [uM] | 0.0 [um2/s] | PM |
| HTR7_Apo_Inactive_Unbound | 0.0 [uM] | 0.0 [um2/s] | PM |
| HTR7_L_Active_Unbound | 0.0 [uM] | 0.0 [um2/s] | PM |
| HTR7_L_Inactive_Unbound | 0.0 [uM] | 0.0 [um2/s] | PM |
| HTR7_L_Active_Gs_GDP | 0.0 [uM] | 0.0 [um2/s] | PM |
| HTR7_L_Active_Gs_Empty | 0.0 [uM] | 0.0 [um2/s] | PM |
| HTR7_L_Active_Gs_GTP | 0.0 [uM] | 0.0 [um2/s] | PM |
| HTR7_Apo_Active_Unbound | 0.0 [uM] | 0.0 [um2/s] | PM |
| B2AR_Apo_Inactive | 0.0 [uM] | 0.0 [um2/s] | PM |
| G12_Empty_s | 0.0 [uM] | 0.0 [um2/s] | PM |
| G12_GDP_S | 0.0 [uM] | 0.0 [um2/s] | PM |
| GRK_Kras_s | 0.0 [uM] | 0.0 [um2/s] | PM |
| HTR7_null_apo | 0.5 [uM] | 0.0 [um2/s] | PM |
Specifications (Reaction) - Application0 go to Simulations
| Name | Enabled? |
|---|---|
| inj1 | included |
| inj2 | included |
| inj3 | included |
| inj4 | included |
| inj5 | included |
| inj6 | included |
| inj7 | included |
| inj8 | included |
| inj9 | included |
| inj10 | included |
| inj11 | included |
| inj12 | included |
| inj13 | included |
| ss_1 | included |
| ss_2 | included |
| GDP_Inj | included |
| GTP_Inj | included |
| inj14 | included |
| inj15 | included |
| inj16 | included |
| ss_3 | excluded |
| ISO1 | included |
| ISO2 | included |
| ISO3 | included |
| ISO_4 | included |
| ISO_5 | included |
| ISO_6 | included |
| ISO_7 | included |
| ISO_8 | included |
| ISO_9 | included |
| ISO_10 | included |
| ISO_11 | included |
| ISO_12 | included |
| ISO_13 | included |
| ISO_14 | included |
| ISO_15 | included |
| ISO_16 | included |
| ss_4 | excluded |
Simulations - Application0 go to Specifications
| Name | End Time | Output Options |
|---|---|---|
| Simulation0 | 650.0 |
OutputTimeStep 0.5 |
Application0 Universal ID's
Application0 Text Annotations
Assignments
| Name | Variable | Assignment Function Expression |
|---|
Events
| Name | Trigger Type | Variable Assignment |
|---|
Geometry non-spatial834646333
(Origin: 0.0, 0.0, 0.0; Extent: 10.0, 10.0, 10.0 [um])
| Dimension | Type | Subdomain | Adjacent Subvolumes | Size | Mapped Compartment |
|---|---|---|---|---|---|
| Compartmental | Compartment | PM |
Events
| Name | Variable | Rate Expression |
|---|
Downloads
| Model Format | Model Downloads |
|---|---|
| Virtual Cell Markup Language | VCML File |
| PDF Report | Report |
| COMBINE Archive | OMEX File |
| SEDML | SEDML File |
| File Format | Application Downloads |
| BNGL | Application0.bngl |
| SBML | Application0.sbml |
| Matlab | Application0.m |
| NFSim XML | Application0.xml |