Physiology

Reaction Diagram

reactionDiagram

Cross-References

Annotations

Reactions

Reactions
Name
Structure
Kinetics
Depiction
Gs_a_PM+AC_PMAC_Gsa_PM 04: Gs-AC binding PM GeneralKinetics
ATP_cellcAMP_cell 05b: cAMP production PM HMMIrreversible
R2C2_cell+cAMP_cellcAMP_R2C2_cell cAMP bind R2C2 cell MassAction
MAPK_active_nucleusMAPK_thr_nucleus MKP2 deact MAPKact nucleus HMMIrreversible
Rap1GAP_cell+Rap1_GTP_GMRap1_RGII_GM 10a: Rap1-RGII binding GM MassAction
cAMP_R2C2_cell+cAMP_cellcAMP2_R2C2_cell cAMP_binds_cAMPR2C2 cell MassAction
Gs_a_PMGsa_GDP_PM Gs GTPase PM GeneralKinetics
Rap1_RGII_GMRap1_GDP_GM+Rap1GAP_cell 10: Rap1 GTPase GM GeneralKinetics
MAPKK_Ser_cellMAPKK_cell PP2A_inact_MAPKKSer cell HMMIrreversible
MAPK_cellMAPK_Thr_cell MAPKK_act_MAPK cell HMMIrreversible
MKP1_RNA_cellMKP1_cell MKP_translation cell MassAction
MAPKK_Ser_cellMAPKK_active_cell reaction1 cell GeneralKinetics
PDE_star_cellPDE_cell PP2A_dephos_PDEstar cell HMMIrreversible
GRK_Gbg_PMGRK_PM+G_bg_PM GRK PM recruitment PM MassAction
PKI_nucleus+PKA_nucleusinhibitedPKA_nucleus PKA inhibition by PKI nucleus MassAction
cAMP_cell+cAMP2_R2C2_cellcAMP3_R2C2_cell cAMP_bind_cAMP2R2C2 cell MassAction
CREB_Ser_nucleusCREB_nucleus Pp2A_deact_CREB nucleus HMMIrreversible
beta_isop_PM+Gs_trimer_PMbetaAR_Gs_PM 2: ARbeta-Gs binding PM MassAction
MKP1gene_nucleusMKP1_RNA_nucleus MAPK_act_MKPtranscription nucleus HMMIrreversible
cAMP_cellAMP_cell PDEstar_deact_cAMP cell HMMIrreversible
beta_isop_PMbeta_P_PM 03: GRK activity PM GeneralKinetics
cAMP4_R2C_cellcAMP4_R2_cell+PKA_cell Release of C2 cell MassAction
MKP1gene_nucleusMKP1_RNA_nucleus MKP1 basal transcription nucleus MassAction
MAPK_Thr_cellMAPK_cell reaction0 cell HMMIrreversible
MAPK_active_cellMAPK_Thr_cell reaction3 cell HMMIrreversible
MAPK_Thr_cellMAPK_cell MKP_decat_MAPKtyr cell HMMIrreversible
MAPKK_Ser_cellMAPKK_active_cell RapRaf_act_MAPKKSer GM HMMIrreversible
MKP1p_cell MKP1p turnover cell MassAction
MKP1p_cellMKP1_cell MKP1 dephosph cell MassAction
MAPK_active_cellMAPK_Thr_cell MKP1p_deact_MAPKactive cell HMMIrreversible
betaAR_Gs_PMbeta_isop_PM+Gs_a_PM+G_bg_PM 02b: Gs activation PM MassAction
BRaf_cell+Rap1_GTP_GMRap1_BRaf_GM Rap1_binds_BRaf GM MassAction
MAPKK_cellMAPKK_Ser_cell BRaf_act_MAPKK cell HMMIrreversible
BRaf_star_cellBRaf_cell PP_deact_BRaf cell HMMIrreversible
BRaf_cellBRaf_star_cell PKA_act_BRaf cell GeneralKinetics
cAMP3_R2C2_cell+cAMP_cellcAMP4_R2C2_cell cAMP_binds_A2 cell MassAction
GRK_PMGRK_cell GRK to cytosol PM MassAction
Rap1_Epac_GMEpac_cAMP_cell+Rap1_GTP_GM 08: Epac exchange GM GeneralKinetics
cAMP4_R2C2_cellcAMP4_R2C_cell+PKA_cell Release of C1 cell MassAction
MAPKK_cellMAPKK_Ser_cell Rap1raf_act_MAPKK GM GeneralKinetics
MKP1_cellMKP1p_cell MKP1 phospho by MAPKactive cell HMMIrreversible
MKP1p_nucleus MKP1p turnover nucleus nucleus MassAction
cAMP_cellAMP_cell 07: PDE cell HMMIrreversible
MAPK_active_nucleusMAPK_thr_nucleus MKP1p deact MAPKact nucleus HMMIrreversible
MKP1_nucleus MKP1 turnover in nucleus nucleus MassAction
isoprenaline_ec+beta_PMbeta_isop_PM 01b: isoprenaline binding PM MassAction
PTPSL_star_cellPTPSL_cell PTPSL_dephos cell HMMIrreversible
MAPK_Thr_cellMAPK_active_cell MAPKK_act_MAPK_thr cell HMMIrreversible
beta_P_PMbeta_PM Receptor recycling PM MassAction
PDE_cellPDE_star_cell PKA_act_PDE cell HMMIrreversible
MAPKK_active_cellMAPKK_Ser_cell PP2A_inact_MAPKK_active cell HMMIrreversible
MAPK_active_cellMAPK_Thr_cell MAPK dephosph by PTP cell HMMIrreversible
G_bg_PM+GRK_cellGRK_Gbg_PM GRK-Gbg binding PM MassAction
MAPK_Thr_cellMAPK_cell MKPp_decat_MAPKtyr cell HMMIrreversible
inhibitedPKA_cellPKI_cell+PKA_cell PKA release by PKI cell MassAction
Rap1_GDP_GM+Epac_cAMP_cellRap1_Epac_GM 8a: Rap1-Epac binding GM MassAction
cAMP_cell+Epac_cellEpac_cAMP_cell Epac-cAMP binding cell MassAction
CREB_nucleusCREB_Ser_nucleus PKA_act_CREB nucleus HMMIrreversible
PTPSL_cellPTPSL_star_cell PKA_deact_PTPSL cell HMMIrreversible
CREB_nucleusCREB_Ser_nucleus MSK_act_CREB nucleus HMMIrreversible
cAMP_cellAMP_cell PDE_highKm deact cAMP cell HMMIrreversible
MSK_active_nucleusMSK_nucleus MSK_dephos nucleus MassAction
Rap1_GDP_GMRap1_GTP_GM constit exch+hydrolysis GM MassAction
MAPK_thr_nucleusMAPK_nucleus MKP1p deact MAPKtyr nucleus HMMIrreversible
CREB_Ser_nucleusCREB_nucleus PP1A_dephos_CREB nucleus HMMIrreversible
MAPK_active_nucleusMAPK_thr_nucleus MKP1 deact MAPKact nucleus HMMIrreversible
Gsa_GDP_PM+G_bg_PMGs_trimer_PM 14b: Gs trimerization PM MassAction
MAPK_thr_nucleusMAPK_nucleus MKP1 deact MAPKtyr nucleus HMMIrreversible
MSK_nucleusMSK_active_nucleus reaction2 nucleus HMMIrreversible
MKP1_cell MKP1 turnover cell MassAction
MAPK_thr_nucleusMAPK_nucleus MKP2 deact MAPK tyr nucleus HMMIrreversible
MKP1_nucleusMKP1p_nucleus MKP1 phosph by MAPKactive_nucleus nucleus HMMIrreversible
MKP1p_nucleusMKP1_nucleus MKP1 dephosph in nucleus nucleus MassAction
MAPK_active_cellMAPK_Thr_cell MKP1_deact_MAPKactive cell HMMIrreversible

04: Gs-AC binding Universal ID's

04: Gs-AC binding Text Annotations

05b: cAMP production Universal ID's

05b: cAMP production Text Annotations

cAMP bind R2C2 Universal ID's

cAMP bind R2C2 Text Annotations

MKP2 deact MAPKact Universal ID's

MKP2 deact MAPKact Text Annotations

10a: Rap1-RGII binding Universal ID's

10a: Rap1-RGII binding Text Annotations

cAMP_binds_cAMPR2C2 Universal ID's

cAMP_binds_cAMPR2C2 Text Annotations

Gs GTPase Universal ID's

Gs GTPase Text Annotations

10: Rap1 GTPase Universal ID's

10: Rap1 GTPase Text Annotations

PP2A_inact_MAPKKSer Universal ID's

PP2A_inact_MAPKKSer Text Annotations

MAPKK_act_MAPK Universal ID's

MAPKK_act_MAPK Text Annotations

MKP_translation Universal ID's

MKP_translation Text Annotations

reaction1 Universal ID's

reaction1 Text Annotations

PP2A_dephos_PDEstar Universal ID's

PP2A_dephos_PDEstar Text Annotations

GRK PM recruitment Universal ID's

GRK PM recruitment Text Annotations

PKA inhibition by PKI Universal ID's

PKA inhibition by PKI Text Annotations

cAMP_bind_cAMP2R2C2 Universal ID's

cAMP_bind_cAMP2R2C2 Text Annotations

Pp2A_deact_CREB Universal ID's

Pp2A_deact_CREB Text Annotations

2: ARbeta-Gs binding Universal ID's

2: ARbeta-Gs binding Text Annotations

MAPK_act_MKPtranscription Universal ID's

MAPK_act_MKPtranscription Text Annotations

PDEstar_deact_cAMP Universal ID's

PDEstar_deact_cAMP Text Annotations

03: GRK activity Universal ID's

03: GRK activity Text Annotations

Release of C2 Universal ID's

Release of C2 Text Annotations

MKP1 basal transcription Universal ID's

MKP1 basal transcription Text Annotations

reaction0 Universal ID's

reaction0 Text Annotations

reaction3 Universal ID's

reaction3 Text Annotations

MKP_decat_MAPKtyr Universal ID's

MKP_decat_MAPKtyr Text Annotations

RapRaf_act_MAPKKSer Universal ID's

RapRaf_act_MAPKKSer Text Annotations

MKP1p turnover Universal ID's

MKP1p turnover Text Annotations

MKP1 dephosph Universal ID's

MKP1 dephosph Text Annotations

MKP1p_deact_MAPKactive Universal ID's

MKP1p_deact_MAPKactive Text Annotations

02b: Gs activation Universal ID's

02b: Gs activation Text Annotations

Rap1_binds_BRaf Universal ID's

Rap1_binds_BRaf Text Annotations

BRaf_act_MAPKK Universal ID's

BRaf_act_MAPKK Text Annotations

PP_deact_BRaf Universal ID's

PP_deact_BRaf Text Annotations

PKA_act_BRaf Universal ID's

PKA_act_BRaf Text Annotations

cAMP_binds_A2 Universal ID's

cAMP_binds_A2 Text Annotations

GRK to cytosol Universal ID's

GRK to cytosol Text Annotations

08: Epac exchange Universal ID's

08: Epac exchange Text Annotations

Release of C1 Universal ID's

Release of C1 Text Annotations

Rap1raf_act_MAPKK Universal ID's

Rap1raf_act_MAPKK Text Annotations

MKP1 phospho by MAPKactive Universal ID's

MKP1 phospho by MAPKactive Text Annotations

MKP1p turnover nucleus Universal ID's

MKP1p turnover nucleus Text Annotations

07: PDE Universal ID's

07: PDE Text Annotations

MKP1p deact MAPKact Universal ID's

MKP1p deact MAPKact Text Annotations

MKP1 turnover in nucleus Universal ID's

MKP1 turnover in nucleus Text Annotations

01b: isoprenaline binding Universal ID's

01b: isoprenaline binding Text Annotations

PTPSL_dephos Universal ID's

PTPSL_dephos Text Annotations

MAPKK_act_MAPK_thr Universal ID's

MAPKK_act_MAPK_thr Text Annotations

Receptor recycling Universal ID's

Receptor recycling Text Annotations

PKA_act_PDE Universal ID's

PKA_act_PDE Text Annotations

PP2A_inact_MAPKK_active Universal ID's

PP2A_inact_MAPKK_active Text Annotations

MAPK dephosph by PTP Universal ID's

MAPK dephosph by PTP Text Annotations

GRK-Gbg binding Universal ID's

GRK-Gbg binding Text Annotations

MKPp_decat_MAPKtyr Universal ID's

MKPp_decat_MAPKtyr Text Annotations

PKA release by PKI Universal ID's

PKA release by PKI Text Annotations

8a: Rap1-Epac binding Universal ID's

8a: Rap1-Epac binding Text Annotations

Epac-cAMP binding Universal ID's

Epac-cAMP binding Text Annotations

PKA_act_CREB Universal ID's

PKA_act_CREB Text Annotations

PKA_deact_PTPSL Universal ID's

PKA_deact_PTPSL Text Annotations

MSK_act_CREB Universal ID's

MSK_act_CREB Text Annotations

PDE_highKm deact cAMP Universal ID's

PDE_highKm deact cAMP Text Annotations

MSK_dephos Universal ID's

MSK_dephos Text Annotations

constit exch+hydrolysis Universal ID's

constit exch+hydrolysis Text Annotations

MKP1p deact MAPKtyr Universal ID's

MKP1p deact MAPKtyr Text Annotations

PP1A_dephos_CREB Universal ID's

PP1A_dephos_CREB Text Annotations

MKP1 deact MAPKact Universal ID's

MKP1 deact MAPKact Text Annotations

14b: Gs trimerization Universal ID's

14b: Gs trimerization Text Annotations

MKP1 deact MAPKtyr Universal ID's

MKP1 deact MAPKtyr Text Annotations

reaction2 Universal ID's

reaction2 Text Annotations

MKP1 turnover Universal ID's

MKP1 turnover Text Annotations

MKP2 deact MAPK tyr Universal ID's

MKP2 deact MAPK tyr Text Annotations

MKP1 phosph by MAPKactive_nucleus Universal ID's

MKP1 phosph by MAPKactive_nucleus Text Annotations

MKP1 dephosph in nucleus Universal ID's

MKP1 dephosph in nucleus Text Annotations

MKP1_deact_MAPKactive Universal ID's

MKP1_deact_MAPKactive Text Annotations

Expressions for 04: Gs-AC binding

reaction rate

J

((AC_PM * Kf_04__Gs_AC_binding * Gs_a_PM) - (Kr_04__Gs_AC_binding * AC_Gsa_PM)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

local

Kf_04__Gs_AC_binding

1.0 [um2.molecules-1.s-1]

local

Kr_04__Gs_AC_binding

3.4 [s-1]

Expressions for 05b: cAMP production

reaction rate

J

((Vmax * ATP_cell) / (Km + ATP_cell)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

Km (1/2 max)

Km

3.15 [uM]

max reaction rate

Vmax

(kcat * AC_Gsa_PM) [molecules.um-2.s-1]

local

kcat

8.5 [s-1]

Expressions for cAMP bind R2C2

reaction rate

J

(((Kf * R2C2_cell) * cAMP_cell) - (Kr * cAMP_R2C2_cell)) [uM.s-1]

forward rate constant

Kf

54.0 [s-1.uM-1]

reverse rate constant

Kr

33.0 [s-1]

Expressions for MKP2 deact MAPKact

reaction rate

J

((Vmax * MAPK_active_nucleus) / (Km + MAPK_active_nucleus)) [uM.s-1]

Km (1/2 max)

Km

0.0667 [uM]

max reaction rate

Vmax

(kcat * MKP2_nucleus) [uM.s-1]

local

kcat

1.0 [s-1]

Expressions for 10a: Rap1-RGII binding

reaction rate

J

(((Kf_10a__Rap1_RGII_binding * Rap1GAP_cell) * Rap1_GTP_GM) - (Kr_10a__Rap1_RGII_binding * Rap1_RGII_GM)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

forward rate constant

Kf_10a__Rap1_RGII_binding

0.62 [s-1.uM-1]

reverse rate constant

Kr_10a__Rap1_RGII_binding

8.7 [s-1]

Expressions for cAMP_binds_cAMPR2C2

reaction rate

J

(((Kf * cAMP_R2C2_cell) * cAMP_cell) - (Kr * cAMP2_R2C2_cell)) [uM.s-1]

forward rate constant

Kf

54.0 [s-1.uM-1]

reverse rate constant

Kr

33.0 [s-1]

Expressions for Gs GTPase

reaction rate

J

(Gs_a_PM * Kcat) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

local

Kcat

0.11 [s-1]

Expressions for 10: Rap1 GTPase

reaction rate

J_10__Rap1_GTPase

(kcat * Rap1_RGII_GM) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

local

kcat

8.0 [s-1]

Expressions for PP2A_inact_MAPKKSer

reaction rate

J

((Vmax * MAPKK_Ser_cell) / (Km + MAPKK_Ser_cell)) [uM.s-1]

Km (1/2 max)

Km

15.66 [uM]

max reaction rate

Vmax

(kcat * PP2A_cell) [uM.s-1]

local

kcat

6.0 [s-1]

Expressions for MAPKK_act_MAPK

reaction rate

J

((Vmax * MAPK_cell) / (Km + MAPK_cell)) [uM.s-1]

Km (1/2 max)

Km

0.046296 [uM]

max reaction rate

Vmax

(kcat * MAPKK_active_cell) [uM.s-1]

local

kcat

0.15 [s-1]

Expressions for MKP_translation

reaction rate

J

((Kf * MKP1_RNA_cell) - (Kr * MKP1_cell)) [uM.s-1]

forward rate constant

Kf

0.004 [s-1]

reverse rate constant

Kr

0.0 [s-1]

Expressions for reaction1

reaction rate

J

(Vmax * MAPKK_Ser_cell / (Km + MAPKK_Ser_cell)) [uM.s-1]

local

Km

0.159 [uM]

local

Vmax

(kcat * BRaf_star_cell) [uM.s-1]

local

kcat

0.105 [s-1]

Expressions for PP2A_dephos_PDEstar

reaction rate

J

((Vmax * PDE_star_cell) / (Km + PDE_star_cell)) [uM.s-1]

Km (1/2 max)

Km

0.96 [uM]

max reaction rate

Vmax

(kcat * PDE_PP_cell) [uM.s-1]

local

kcat

0.77 [s-1]

Expressions for GRK PM recruitment

reaction rate

J

((Kf_GRK_PM_recruitment * GRK_Gbg_PM) - ((Kr_GRK_PM_recruitment * GRK_PM) * G_bg_PM)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

forward rate constant

Kf_GRK_PM_recruitment

1.0 [s-1]

reverse rate constant

Kr_GRK_PM_recruitment

1.0E-4 [um2.s-1.molecules-1]

Expressions for PKA inhibition by PKI

reaction rate

J

(((Kf * PKI_nucleus) * PKA_nucleus) - (Kr * inhibitedPKA_nucleus)) [uM.s-1]

forward rate constant

Kf

1.0 [s-1.uM-1]

reverse rate constant

Kr

1.0E-4 [s-1]

Expressions for cAMP_bind_cAMP2R2C2

reaction rate

J

(((Kf * cAMP_cell) * cAMP2_R2C2_cell) - (Kr * cAMP3_R2C2_cell)) [uM.s-1]

forward rate constant

Kf

75.0 [s-1.uM-1]

reverse rate constant

Kr

110.0 [s-1]

Expressions for Pp2A_deact_CREB

reaction rate

J

((Vmax * CREB_Ser_nucleus) / (Km + CREB_Ser_nucleus)) [uM.s-1]

Km (1/2 max)

Km

15.66 [uM]

max reaction rate

Vmax

(kcat * pp2a_nucleus) [uM.s-1]

local

kcat

6.0 [s-1]

Expressions for 2: ARbeta-Gs binding

reaction rate

J

(((Kf_2__ARbeta_Gs_binding * beta_isop_PM) * Gs_trimer_PM) - (Kr_2__ARbeta_Gs_binding * betaAR_Gs_PM)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

forward rate constant

Kf_2__ARbeta_Gs_binding

0.01 [um2.s-1.molecules-1]

reverse rate constant

Kr_2__ARbeta_Gs_binding

0.1 [s-1]

Expressions for MAPK_act_MKPtranscription

reaction rate

J

((Vmax * MKP1gene_nucleus) / (Km + MKP1gene_nucleus)) [uM.s-1]

Km (1/2 max)

Km

4.0 [uM]

max reaction rate

Vmax

(kcat * MAPK_active_nucleus) [uM.s-1]

local

kcat

3.0E-4 [s-1]

Expressions for PDEstar_deact_cAMP

reaction rate

J

((Vmax * cAMP_cell) / (Km + cAMP_cell)) [uM.s-1]

Km (1/2 max)

Km

1.3 [uM]

max reaction rate

Vmax

(kcat * PDE_star_cell) [uM.s-1]

local

kcat

20.0 [s-1]

Expressions for 03: GRK activity

reaction rate

J_3__GRK_activity

((beta_isop_PM * GRK_PM * kCATgrk / (KM + beta_isop_PM)) - (beta_P_PM * kdephos)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

local

KM

250.0 [molecules.um-2]

local

kdephos

0.0 [s-1]

local

kCATgrk

0.204 [s-1]

Expressions for Release of C2

reaction rate

J

((Kf * cAMP4_R2C_cell) - ((Kr * cAMP4_R2_cell) * PKA_cell)) [uM.s-1]

forward rate constant

Kf

0.6 [s-1]

reverse rate constant

Kr

0.18 [s-1.uM-1]

Expressions for MKP1 basal transcription

reaction rate

J

((Kf * MKP1gene_nucleus) - (Kr * MKP1_RNA_nucleus)) [uM.s-1]

forward rate constant

Kf

2.0E-6 [s-1]

reverse rate constant

Kr

0.0 [s-1]

Expressions for reaction0

reaction rate

J

((Vmax * MAPK_Thr_cell) / (Km + MAPK_Thr_cell)) [uM.s-1]

Km (1/2 max)

Km

0.06667 [uM]

max reaction rate

Vmax

MKP2_cell [uM.s-1]

Expressions for reaction3

reaction rate

J

((Vmax * MAPK_active_cell) / (Km + MAPK_active_cell)) [uM.s-1]

Km (1/2 max)

Km

0.06667 [uM]

max reaction rate

Vmax

MKP2_cell [uM.s-1]

Expressions for MKP_decat_MAPKtyr

reaction rate

J

((Vmax * MAPK_Thr_cell) / (Km + MAPK_Thr_cell)) [uM.s-1]

Km (1/2 max)

Km

0.067 [uM]

max reaction rate

Vmax

(kcat * MKP1_cell) [uM.s-1]

local

kcat

1.0 [s-1]

Expressions for RapRaf_act_MAPKKSer

reaction rate

J

((Vmax * MAPKK_Ser_cell) / (Km + MAPKK_Ser_cell)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

Km (1/2 max)

Km

0.4 [uM]

max reaction rate

Vmax

(kcat * Rap1_BRaf_GM) [molecules.um-2.s-1]

local

kcat

0.95 [s-1]

Expressions for MKP1p turnover

reaction rate

J

(Kf * MKP1p_cell) [uM.s-1]

forward rate constant

Kf

1.0E-4 [s-1]

reverse rate constant

Kr

0.0 [uM.s-1]

Expressions for MKP1 dephosph

reaction rate

J

((Kf * MKP1p_cell) - (Kr * MKP1_cell)) [uM.s-1]

forward rate constant

Kf

1.0E-4 [s-1]

reverse rate constant

Kr

0.0 [s-1]

Expressions for MKP1p_deact_MAPKactive

reaction rate

J

((Vmax * MAPK_active_cell) / (Km + MAPK_active_cell)) [uM.s-1]

Km (1/2 max)

Km

0.0667 [uM]

max reaction rate

Vmax

(kcat * MKP1p_cell) [uM.s-1]

local

kcat

1.0 [s-1]

Expressions for 02b: Gs activation

reaction rate

J

((Kf * betaAR_Gs_PM) - (((Kr * beta_isop_PM) * Gs_a_PM) * G_bg_PM)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

forward rate constant

Kf

0.025 [s-1]

reverse rate constant

Kr

0.0 [um4.s-1.molecules-2]

Expressions for Rap1_binds_BRaf

reaction rate

J

(((Kf * BRaf_cell) * Rap1_GTP_GM) - (Kr * Rap1_BRaf_GM)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

forward rate constant

Kf

4.0 [s-1.uM-1]

reverse rate constant

Kr

10.0 [s-1]

Expressions for BRaf_act_MAPKK

reaction rate

J

((Vmax * MAPKK_cell) / (Km + MAPKK_cell)) [uM.s-1]

Km (1/2 max)

Km

0.159 [uM]

max reaction rate

Vmax

(kcat * BRaf_star_cell) [uM.s-1]

local

kcat

0.105 [s-1]

Expressions for PP_deact_BRaf

reaction rate

J

((Vmax * BRaf_star_cell) / (Km + BRaf_star_cell)) [uM.s-1]

Km (1/2 max)

Km

15.66 [uM]

max reaction rate

Vmax

(kcat * PP2A_cell) [uM.s-1]

local

kcat

6.0 [s-1]

Expressions for PKA_act_BRaf

reaction rate

J

(Vmax * BRaf_cell / (Km + BRaf_cell)) [uM.s-1]

local

Km

1.0 [uM]

local

Vmax

(kcat * PKA_cell) [uM.s-1]

local

kcat

0.1 [s-1]

Expressions for cAMP_binds_A2

reaction rate

J

(((Kf * cAMP3_R2C2_cell) * cAMP_cell) - (Kr * cAMP4_R2C2_cell)) [uM.s-1]

forward rate constant

Kf

75.0 [s-1.uM-1]

reverse rate constant

Kr

32.5 [s-1]

Expressions for GRK to cytosol

reaction rate

J

((Kf * GRK_PM) - (Kr * GRK_cell)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

forward rate constant

Kf

0.01 [s-1]

reverse rate constant

Kr

0.0 [molecules.um-2.s-1.uM-1]

Expressions for 08: Epac exchange

reaction rate

J_08__Epac_exchange

(Rap1_Epac_GM * kEpacEXCH) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

local

kEpacEXCH

0.2 [s-1]

Expressions for Release of C1

reaction rate

J

((Kf * cAMP4_R2C2_cell) - ((Kr * cAMP4_R2C_cell) * PKA_cell)) [uM.s-1]

forward rate constant

Kf

0.6 [s-1]

reverse rate constant

Kr

0.18 [s-1.uM-1]

Expressions for Rap1raf_act_MAPKK

reaction rate

J

(Vmax * MAPKK_cell / (Km + MAPKK_cell)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

local

Km

0.4 [uM]

local

Vmax

(kcat * Rap1_BRaf_GM) [molecules.um-2.s-1]

local

kcat

0.95 [s-1]

Expressions for MKP1 phospho by MAPKactive

reaction rate

J

((Vmax * MKP1_cell) / (Km + MKP1_cell)) [uM.s-1]

Km (1/2 max)

Km

25.641 [uM]

max reaction rate

Vmax

(kcat * MAPK_active_cell) [uM.s-1]

local

kcat

1.0 [s-1]

Expressions for MKP1p turnover nucleus

reaction rate

J

(Kf * MKP1p_nucleus) [uM.s-1]

forward rate constant

Kf

1.0E-4 [s-1]

reverse rate constant

Kr

0.0 [uM.s-1]

Expressions for 07: PDE

reaction rate

J

((Vmax_07__PDE * cAMP_cell) / (Km_07__PDE + cAMP_cell)) [uM.s-1]

Km (1/2 max)

Km_07__PDE

1.3 [uM]

max reaction rate

Vmax_07__PDE

(kCATpde * PDE_cell) [uM.s-1]

local

kCATpde

8.0 [s-1]

Expressions for MKP1p deact MAPKact

reaction rate

J

((Vmax * MAPK_active_nucleus) / (Km + MAPK_active_nucleus)) [uM.s-1]

Km (1/2 max)

Km

0.0667 [uM]

max reaction rate

Vmax

(kcat * MKP1p_nucleus) [uM.s-1]

local

kcat

1.0 [s-1]

Expressions for MKP1 turnover in nucleus

reaction rate

J

(Kf * MKP1_nucleus) [uM.s-1]

forward rate constant

Kf

3.7E-4 [s-1]

reverse rate constant

Kr

0.0 [uM.s-1]

Expressions for 01b: isoprenaline binding

reaction rate

J

(((Kf_01b__isoprenaline_binding * isoprenaline_ec) * beta_PM) - (Kr_01b__isoprenaline_binding * beta_isop_PM)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

forward rate constant

Kf_01b__isoprenaline_binding

0.1 [s-1.uM-1]

reverse rate constant

Kr_01b__isoprenaline_binding

0.1 [s-1]

Expressions for PTPSL_dephos

reaction rate

J

((Vmax * PTPSL_star_cell) / (Km + PTPSL_star_cell)) [uM.s-1]

Km (1/2 max)

Km

6.0 [uM]

max reaction rate

Vmax

(kcat * PP1_cell) [uM.s-1]

local

kcat

5.0 [s-1]

Expressions for MAPKK_act_MAPK_thr

reaction rate

J

((Vmax * MAPK_Thr_cell) / (Km + MAPK_Thr_cell)) [uM.s-1]

Km (1/2 max)

Km

0.046296 [uM]

max reaction rate

Vmax

(kcat * MAPKK_active_cell) [uM.s-1]

local

kcat

0.15 [s-1]

Expressions for Receptor recycling

reaction rate

J

((Kf * beta_P_PM) - (Kr * beta_PM)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

forward rate constant

Kf

4.7E-4 [s-1]

reverse rate constant

Kr

0.0 [s-1]

Expressions for PKA_act_PDE

reaction rate

J

((Vmax * PDE_cell) / (Km + PDE_cell)) [uM.s-1]

Km (1/2 max)

Km

0.5 [uM]

max reaction rate

Vmax

(kcat * PKA_cell) [uM.s-1]

local

kcat

9.0 [s-1]

Expressions for PP2A_inact_MAPKK_active

reaction rate

J

((Vmax * MAPKK_active_cell) / (Km + MAPKK_active_cell)) [uM.s-1]

Km (1/2 max)

Km

15.66 [uM]

max reaction rate

Vmax

(kcat * PP2A_cell) [uM.s-1]

local

kcat

6.0 [s-1]

Expressions for MAPK dephosph by PTP

reaction rate

J

((Vmax * MAPK_active_cell) / (Km + MAPK_active_cell)) [uM.s-1]

Km (1/2 max)

Km

0.5 [uM]

max reaction rate

Vmax

(kcat * PTPSL_cell) [uM.s-1]

local

kcat

1.0 [s-1]

Expressions for GRK-Gbg binding

reaction rate

J

(((Kf * G_bg_PM) * GRK_cell) - (Kr * GRK_Gbg_PM)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

forward rate constant

Kf

1.0 [s-1.uM-1]

reverse rate constant

Kr

0.25 [s-1]

Expressions for MKPp_decat_MAPKtyr

reaction rate

J

((Vmax * MAPK_Thr_cell) / (Km + MAPK_Thr_cell)) [uM.s-1]

Km (1/2 max)

Km

0.067 [uM]

max reaction rate

Vmax

(kcat * MKP1p_cell) [uM.s-1]

local

kcat

1.0 [s-1]

Expressions for PKA release by PKI

reaction rate

J

((Kf * inhibitedPKA_cell) - ((Kr * PKI_cell) * PKA_cell)) [uM.s-1]

forward rate constant

Kf

1.0E-4 [s-1]

reverse rate constant

Kr

0.0 [s-1.uM-1]

Expressions for 8a: Rap1-Epac binding

reaction rate

J

(((Kf_8a__Rap1_Epac_binding * Rap1_GDP_GM) * Epac_cAMP_cell) - (Kr_8a__Rap1_Epac_binding * Rap1_Epac_GM)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

forward rate constant

Kf_8a__Rap1_Epac_binding

2.0 [s-1.uM-1]

reverse rate constant

Kr_8a__Rap1_Epac_binding

0.8 [s-1]

Expressions for Epac-cAMP binding

reaction rate

J

(((Kf_06__Epac_cAMP_binding * cAMP_cell) * Epac_cell) - (Kr_06__Epac_cAMP_binding * Epac_cAMP_cell)) [uM.s-1]

forward rate constant

Kf_06__Epac_cAMP_binding

32.0 [s-1.uM-1]

reverse rate constant

Kr_06__Epac_cAMP_binding

96.0 [s-1]

Expressions for PKA_act_CREB

reaction rate

J

((Vmax * CREB_nucleus) / (Km + CREB_nucleus)) [uM.s-1]

Km (1/2 max)

Km

17.0 [uM]

max reaction rate

Vmax

(kcat * PKA_nucleus) [uM.s-1]

local

kcat

6.0 [s-1]

Expressions for PKA_deact_PTPSL

reaction rate

J

((Vmax * PTPSL_cell) / (Km + PTPSL_cell)) [uM.s-1]

Km (1/2 max)

Km

0.1 [uM]

max reaction rate

Vmax

(kcat * PKA_cell) [uM.s-1]

local

kcat

0.2 [s-1]

Expressions for MSK_act_CREB

reaction rate

J

((Vmax * CREB_nucleus) / (Km + CREB_nucleus)) [uM.s-1]

Km (1/2 max)

Km

2.0 [uM]

max reaction rate

Vmax

(kcat * MSK_active_nucleus) [uM.s-1]

local

kcat

1.5 [s-1]

Expressions for PDE_highKm deact cAMP

reaction rate

J

((Vmax * cAMP_cell) / (Km + cAMP_cell)) [uM.s-1]

Km (1/2 max)

Km

15.0 [uM]

max reaction rate

Vmax

(kcat * PDE_highKm_cell) [uM.s-1]

local

kcat

8.0 [s-1]

Expressions for MSK_dephos

reaction rate

J

((Kf * MSK_active_nucleus) - (Kr * MSK_nucleus)) [uM.s-1]

forward rate constant

Kf

0.04 [s-1]

reverse rate constant

Kr

0.0 [s-1]

Expressions for constit exch+hydrolysis

reaction rate

J

((Kf * Rap1_GDP_GM) - (Kr * Rap1_GTP_GM)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

forward rate constant

Kf

3.0E-6 [s-1]

reverse rate constant

Kr

8.5E-5 [s-1]

Expressions for MKP1p deact MAPKtyr

reaction rate

J

((Vmax * MAPK_thr_nucleus) / (Km + MAPK_thr_nucleus)) [uM.s-1]

Km (1/2 max)

Km

0.0667 [uM]

max reaction rate

Vmax

(kcat * MKP1p_nucleus) [uM.s-1]

local

kcat

1.0 [s-1]

Expressions for PP1A_dephos_CREB

reaction rate

J

((Vmax * CREB_Ser_nucleus) / (Km + CREB_Ser_nucleus)) [uM.s-1]

Km (1/2 max)

Km

3.0 [uM]

max reaction rate

Vmax

(kcatPP1A * PP1A_nucleus) [uM.s-1]

local

kcatPP1A

0.4 [s-1]

Expressions for MKP1 deact MAPKact

reaction rate

J

((Vmax * MAPK_active_nucleus) / (Km + MAPK_active_nucleus)) [uM.s-1]

Km (1/2 max)

Km

0.0667 [uM]

max reaction rate

Vmax

(kcat * MKP1_nucleus) [uM.s-1]

local

kcat

1.0 [s-1]

Expressions for 14b: Gs trimerization

reaction rate

J

(((Kf_14b__Gs_trimerization * Gsa_GDP_PM) * G_bg_PM) - (Kr_14b__Gs_trimerization * Gs_trimer_PM)) [molecules.um-2.s-1]

inward current density

I

0.0 [pA.um-2]

net charge valence

netValence

0.0 [1]

forward rate constant

Kf_14b__Gs_trimerization

0.006 [um2.s-1.molecules-1]

reverse rate constant

Kr_14b__Gs_trimerization

0.0 [s-1]

Expressions for MKP1 deact MAPKtyr

reaction rate

J

((Vmax * MAPK_thr_nucleus) / (Km + MAPK_thr_nucleus)) [uM.s-1]

Km (1/2 max)

Km

0.0667 [uM]

max reaction rate

Vmax

(kcat * MKP1_nucleus) [uM.s-1]

local

kcat

1.0 [s-1]

Expressions for reaction2

reaction rate

J

((Vmax * MSK_nucleus) / (Km + MSK_nucleus)) [uM.s-1]

Km (1/2 max)

Km

25.0 [uM]

max reaction rate

Vmax

(kcat * MAPK_active_nucleus) [uM.s-1]

local

kcat

10.0 [s-1]

Expressions for MKP1 turnover

reaction rate

J

(Kf * MKP1_cell) [uM.s-1]

forward rate constant

Kf

3.7E-4 [s-1]

reverse rate constant

Kr

0.0 [uM.s-1]

Expressions for MKP2 deact MAPK tyr

reaction rate

J

((Vmax * MAPK_thr_nucleus) / (Km + MAPK_thr_nucleus)) [uM.s-1]

Km (1/2 max)

Km

0.0667 [uM]

max reaction rate

Vmax

(kcat * MKP2_nucleus) [uM.s-1]

local

kcat

1.0 [s-1]

Expressions for MKP1 phosph by MAPKactive_nucleus

reaction rate

J

((Vmax * MKP1_nucleus) / (Km + MKP1_nucleus)) [uM.s-1]

Km (1/2 max)

Km

25.641 [uM]

max reaction rate

Vmax

(kcat * MAPK_active_nucleus) [uM.s-1]

local

kcat

1.0 [s-1]

Expressions for MKP1 dephosph in nucleus

reaction rate

J

((Kf * MKP1p_nucleus) - (Kr * MKP1_nucleus)) [uM.s-1]

forward rate constant

Kf

1.0E-4 [s-1]

reverse rate constant

Kr

0.0 [s-1]

Expressions for MKP1_deact_MAPKactive

reaction rate

J

((Vmax * MAPK_active_cell) / (Km + MAPK_active_cell)) [uM.s-1]

Km (1/2 max)

Km

0.0667 [uM]

max reaction rate

Vmax

(kcat * MKP1_cell) [uM.s-1]

local

kcat

1.0 [s-1]

Structures

Name
Type
Electrical
GM Membrane golgi(+)   cell(-)
PM Membrane cell(+)   ec(-)
nuclear membrane Membrane nucleus(+)   cell(-)
golgi Compartment (+)   (-)
cell Compartment (+)   (-)
ec Compartment (+)   (-)
nucleus Compartment (+)   (-)

GM Universal ID's

GM Text Annotations

PM Universal ID's

PM Text Annotations

nuclear membrane Universal ID's

nuclear membrane Text Annotations

golgi Universal ID's

golgi Text Annotations

cell Universal ID's

cell Text Annotations

ec Universal ID's

ec Text Annotations

nucleus Universal ID's

nucleus Text Annotations

Species

Name
Structure
BioNetGen Definition
Depiction
MSK_active_nucleus nucleus nucleus
AMP_cell cell cell
BRaf_cell cell cell
MAPK_act_cell cell cell
cAMP4_R2C2_cell cell cell
cAMP4_R2C_cell cell cell
cAMP4_R2_cell cell cell
MAPK_nucleus nucleus nucleus
MKP1_nucleus nucleus nucleus
MKP2_nucleus nucleus nucleus
MAPK_thr_nucleus nucleus nucleus
MKP1p_cell cell cell
MKP1p_nucleus nucleus nucleus
MKP2_cell cell cell
G_bg_PM PM PM
Rap1_RGII_GM GM GM
Gsa_GDP_PM PM PM
beta_isop_PM PM PM
PDE_star_cell cell cell
isoprenaline_ec ec ec
MKP1gene_nucleus nucleus nucleus
MSK_nucleus nucleus nucleus
R2C2_cell cell cell
PP2A_cell cell cell
MAPK_active_nucleus nucleus nucleus
cAMP_R2C2_cell cell cell
Rap1_GDP_GM GM GM
beta_PM PM PM
Epac_cAMP_cell cell cell
beta_P_PM PM PM
Rap1_Epac_GM GM GM
MKP1_RNA_nucleus nucleus nucleus
cAMP2_R2C2_cell cell cell
PKA_cell cell cell
MAPKK_Ser_cell cell cell
PKI_cell cell cell
inhibitedPKA_nucleus nucleus nucleus
inhibitedPKA_cell cell cell
Gs_trimer_PM PM PM
GRK_Gbg_PM PM PM
Gs_a_PM PM PM
MAPK_active_cell cell cell
Rap1GAP_cell cell cell
MAPKK_cell cell cell
cAMP3_R2C2_cell cell cell
cAMP_cell cell cell
PP1_cell cell cell
PP1A_nucleus nucleus nucleus
CREB_Ser_nucleus nucleus nucleus
PTPSL_star_cell cell cell
Epac_cell cell cell
MKP1_RNA_cell cell cell
Rap1_BRaf_GM GM GM
MAPKK_active_cell cell cell
PKI_nucleus nucleus nucleus
GRK_cell cell cell
AC_PM PM PM
AC_Gsa_PM PM PM
PDE_cell cell cell
Rap1_GTP_GM GM GM
pp2a_nucleus nucleus nucleus
CREB_nucleus nucleus nucleus
PTPSL_cell cell cell
MAPK_Thr_cell cell cell
PDE_PP_cell cell cell
PDE_highKm_cell cell cell
GRK_PM PM PM
betaAR_Gs_PM PM PM
BRaf_star_cell cell cell
PKA_nucleus nucleus nucleus
MAPK_cell cell cell
ATP_cell cell cell
MKP1_cell cell cell

MSK_active_nucleus Universal ID's

MSK_active_nucleus Text Annotations

AMP_cell Universal ID's

AMP_cell Text Annotations

BRaf_cell Universal ID's

BRaf_cell Text Annotations

MAPK_act_cell Universal ID's

MAPK_act_cell Text Annotations

cAMP4_R2C2_cell Universal ID's

cAMP4_R2C2_cell Text Annotations

cAMP4_R2C_cell Universal ID's

cAMP4_R2C_cell Text Annotations

cAMP4_R2_cell Universal ID's

cAMP4_R2_cell Text Annotations

MAPK_nucleus Universal ID's

MAPK_nucleus Text Annotations

MKP1_nucleus Universal ID's

MKP1_nucleus Text Annotations

MKP2_nucleus Universal ID's

MKP2_nucleus Text Annotations

MAPK_thr_nucleus Universal ID's

MAPK_thr_nucleus Text Annotations

MKP1p_cell Universal ID's

MKP1p_cell Text Annotations

MKP1p_nucleus Universal ID's

MKP1p_nucleus Text Annotations

MKP2_cell Universal ID's

MKP2_cell Text Annotations

G_bg_PM Universal ID's

G_bg_PM Text Annotations

Rap1_RGII_GM Universal ID's

Rap1_RGII_GM Text Annotations

Gsa_GDP_PM Universal ID's

Gsa_GDP_PM Text Annotations

beta_isop_PM Universal ID's

beta_isop_PM Text Annotations

PDE_star_cell Universal ID's

PDE_star_cell Text Annotations

isoprenaline_ec Universal ID's

isoprenaline_ec Text Annotations

MKP1gene_nucleus Universal ID's

MKP1gene_nucleus Text Annotations

MSK_nucleus Universal ID's

MSK_nucleus Text Annotations

R2C2_cell Universal ID's

R2C2_cell Text Annotations

PP2A_cell Universal ID's

PP2A_cell Text Annotations

MAPK_active_nucleus Universal ID's

MAPK_active_nucleus Text Annotations

cAMP_R2C2_cell Universal ID's

cAMP_R2C2_cell Text Annotations

Rap1_GDP_GM Universal ID's

Rap1_GDP_GM Text Annotations

beta_PM Universal ID's

beta_PM Text Annotations

Epac_cAMP_cell Universal ID's

Epac_cAMP_cell Text Annotations

beta_P_PM Universal ID's

beta_P_PM Text Annotations

Rap1_Epac_GM Universal ID's

Rap1_Epac_GM Text Annotations

MKP1_RNA_nucleus Universal ID's

MKP1_RNA_nucleus Text Annotations

cAMP2_R2C2_cell Universal ID's

cAMP2_R2C2_cell Text Annotations

PKA_cell Universal ID's

PKA_cell Text Annotations

MAPKK_Ser_cell Universal ID's

MAPKK_Ser_cell Text Annotations

PKI_cell Universal ID's

PKI_cell Text Annotations

inhibitedPKA_nucleus Universal ID's

inhibitedPKA_nucleus Text Annotations

inhibitedPKA_cell Universal ID's

inhibitedPKA_cell Text Annotations

Gs_trimer_PM Universal ID's

Gs_trimer_PM Text Annotations

GRK_Gbg_PM Universal ID's

GRK_Gbg_PM Text Annotations

Gs_a_PM Universal ID's

Gs_a_PM Text Annotations

MAPK_active_cell Universal ID's

MAPK_active_cell Text Annotations

Rap1GAP_cell Universal ID's

Rap1GAP_cell Text Annotations

MAPKK_cell Universal ID's

MAPKK_cell Text Annotations

cAMP3_R2C2_cell Universal ID's

cAMP3_R2C2_cell Text Annotations

cAMP_cell Universal ID's

cAMP_cell Text Annotations

PP1_cell Universal ID's

PP1_cell Text Annotations

PP1A_nucleus Universal ID's

PP1A_nucleus Text Annotations

CREB_Ser_nucleus Universal ID's

CREB_Ser_nucleus Text Annotations

PTPSL_star_cell Universal ID's

PTPSL_star_cell Text Annotations

Epac_cell Universal ID's

Epac_cell Text Annotations

MKP1_RNA_cell Universal ID's

MKP1_RNA_cell Text Annotations

Rap1_BRaf_GM Universal ID's

Rap1_BRaf_GM Text Annotations

MAPKK_active_cell Universal ID's

MAPKK_active_cell Text Annotations

PKI_nucleus Universal ID's

PKI_nucleus Text Annotations

GRK_cell Universal ID's

GRK_cell Text Annotations

AC_PM Universal ID's

AC_PM Text Annotations

AC_Gsa_PM Universal ID's

AC_Gsa_PM Text Annotations

PDE_cell Universal ID's

PDE_cell Text Annotations

Rap1_GTP_GM Universal ID's

Rap1_GTP_GM Text Annotations

pp2a_nucleus Universal ID's

pp2a_nucleus Text Annotations

CREB_nucleus Universal ID's

CREB_nucleus Text Annotations

PTPSL_cell Universal ID's

PTPSL_cell Text Annotations

MAPK_Thr_cell Universal ID's

MAPK_Thr_cell Text Annotations

PDE_PP_cell Universal ID's

PDE_PP_cell Text Annotations

PDE_highKm_cell Universal ID's

PDE_highKm_cell Text Annotations

GRK_PM Universal ID's

GRK_PM Text Annotations

betaAR_Gs_PM Universal ID's

betaAR_Gs_PM Text Annotations

BRaf_star_cell Universal ID's

BRaf_star_cell Text Annotations

PKA_nucleus Universal ID's

PKA_nucleus Text Annotations

MAPK_cell Universal ID's

MAPK_cell Text Annotations

ATP_cell Universal ID's

ATP_cell Text Annotations

MKP1_cell Universal ID's

MKP1_cell Text Annotations

Molecules

Name
BioNetGen Definition
DEPICTION

Observables

Name
Structure
Count
BNGL Definition
Sequence Type
DEPICTION

Applications

Name
Properties Math Type
Annotation
Compart Specs - Species
Specs - Reaction
Simulations 		Deterministic (ODE) Compartmental cloned from 'Compart' owned by user eungdamr cloned from 'Compart' owned by user argh

Compart Universal ID's

Compart Text Annotations

Specifications (Species) - Compart go to Simulations

Species
Initial Condition
Diffusion Constant
Structure
AMP_cell 1.0E-6 [uM] 0.0 [um2/s] cell
BRaf_cell 0.2 [uM] 0.0 [um2/s] cell
MAPK_act_cell 0.0 [uM] 0.0 [um2/s] cell
cAMP4_R2C2_cell 0.0 [uM] 0.0 [um2/s] cell
cAMP4_R2C_cell 0.0 [uM] 0.0 [um2/s] cell
cAMP4_R2_cell 0.0 [uM] 0.0 [um2/s] cell
MKP1p_cell 0.0 [uM] 0.0 [um2/s] cell
MKP2_cell 0.001 [uM] 0.0 [um2/s] cell
PDE_star_cell 0.0 [uM] 0.0 [um2/s] cell
R2C2_cell 0.2 [uM] 0.0 [um2/s] cell
PP2A_cell 0.075 [uM] 0.0 [um2/s] cell
cAMP_R2C2_cell 0.0 [uM] 0.0 [um2/s] cell
Epac_cAMP_cell 1.0E-6 [uM] 0.0 [um2/s] cell
cAMP2_R2C2_cell 0.0 [uM] 0.0 [um2/s] cell
PKA_cell 0.0 [uM] 0.0 [um2/s] cell
MAPKK_Ser_cell 1.0E-6 [uM] 0.0 [um2/s] cell
PKI_cell 0.4 [uM] 0.0 [um2/s] cell
inhibitedPKA_cell 0.0 [uM] 0.0 [um2/s] cell
MAPK_active_cell 0.0 [uM] 0.0 [um2/s] cell
Rap1GAP_cell 0.15 [uM] 0.0 [um2/s] cell
MAPKK_cell 0.18 [uM] 0.0 [um2/s] cell
cAMP3_R2C2_cell 0.0 [uM] 0.0 [um2/s] cell
cAMP_cell 1.0E-4 [uM] 0.0 [um2/s] cell
PP1_cell 0.04 [uM] 0.0 [um2/s] cell
PTPSL_star_cell 0.0 [uM] 0.0 [um2/s] cell
Epac_cell 0.16 [uM] 0.0 [um2/s] cell
MKP1_RNA_cell 4.0E-5 [uM] 0.0 [um2/s] cell
MAPKK_active_cell 1.0E-6 [uM] 0.0 [um2/s] cell
GRK_cell 0.045 [uM] 0.0 [um2/s] cell
PDE_cell 0.4 [uM] 0.0 [um2/s] cell
PTPSL_cell 0.01 [uM] 0.0 [um2/s] cell
MAPK_Thr_cell 0.0 [uM] 0.0 [um2/s] cell
PDE_PP_cell 0.2 [uM] 0.0 [um2/s] cell
PDE_highKm_cell 0.5 [uM] 0.0 [um2/s] cell
BRaf_star_cell 0.0 [uM] 0.0 [um2/s] cell
MAPK_cell 0.263 [uM] 0.0 [um2/s] cell
ATP_cell 4000.0 [uM] 0.0 [um2/s] cell
MKP1_cell 3.6E-4 [uM] 0.0 [um2/s] cell
isoprenaline_ec 10.0 [uM] 0.0 [um2/s] ec
MSK_active_nucleus 0.0 [uM] 0.0 [um2/s] nucleus
MAPK_nucleus 0.233 [uM] 0.0 [um2/s] nucleus
MKP1_nucleus 2.2E-4 [uM] 0.0 [um2/s] nucleus
MKP2_nucleus 1.0E-4 [uM] 0.0 [um2/s] nucleus
MAPK_thr_nucleus 0.0 [uM] 0.0 [um2/s] nucleus
MKP1p_nucleus 0.0 [uM] 0.0 [um2/s] nucleus
MKP1gene_nucleus 0.2 [uM] 0.0 [um2/s] nucleus
MSK_nucleus 0.1 [uM] 0.0 [um2/s] nucleus
MAPK_active_nucleus 0.0 [uM] 0.0 [um2/s] nucleus
MKP1_RNA_nucleus 6.5E-7 [uM] 0.0 [um2/s] nucleus
inhibitedPKA_nucleus 0.0 [uM] 0.0 [um2/s] nucleus
PP1A_nucleus 0.04 [uM] 0.0 [um2/s] nucleus
CREB_Ser_nucleus 0.0 [uM] 0.0 [um2/s] nucleus
PKI_nucleus 0.0 [uM] 0.0 [um2/s] nucleus
pp2a_nucleus 0.05 [uM] 0.0 [um2/s] nucleus
CREB_nucleus 0.3 [uM] 0.0 [um2/s] nucleus
PKA_nucleus 0.0 [uM] 0.0 [um2/s] nucleus
Rap1_RGII_GM 0.0 [uM] 0.0 [um2/s] GM
Rap1_GDP_GM 100.0 [uM] 0.0 [um2/s] GM
Rap1_Epac_GM 0.0 [uM] 0.0 [um2/s] GM
Rap1_BRaf_GM 0.0 [uM] 0.0 [um2/s] GM
Rap1_GTP_GM 0.0 [uM] 0.0 [um2/s] GM
G_bg_PM 0.0 [uM] 0.0 [um2/s] PM
Gsa_GDP_PM 1.0E-6 [uM] 0.0 [um2/s] PM
beta_isop_PM 1.0E-6 [uM] 0.0 [um2/s] PM
beta_PM 33.0 [uM] 0.0 [um2/s] PM
beta_P_PM 1.0E-6 [uM] 0.0 [um2/s] PM
Gs_trimer_PM 100.0 [uM] 0.0 [um2/s] PM
GRK_Gbg_PM 0.0 [uM] 0.0 [um2/s] PM
Gs_a_PM 1.0E-6 [uM] 0.0 [um2/s] PM
AC_PM 100.0 [uM] 0.0 [um2/s] PM
AC_Gsa_PM 1.0E-6 [uM] 0.0 [um2/s] PM
GRK_PM 1.0E-6 [uM] 0.0 [um2/s] PM
betaAR_Gs_PM 0.0 [uM] 0.0 [um2/s] PM

Specifications (Reaction) - Compart go to Simulations

Name
Enabled?
04: Gs-AC binding included
05b: cAMP production included
cAMP bind R2C2 included
MKP2 deact MAPKact included
10a: Rap1-RGII binding included
cAMP_binds_cAMPR2C2 included
Gs GTPase included
10: Rap1 GTPase included
PP2A_inact_MAPKKSer included
MAPKK_act_MAPK included
MKP_translation included
reaction1 included
PP2A_dephos_PDEstar included
GRK PM recruitment included
PKA inhibition by PKI included
cAMP_bind_cAMP2R2C2 included
Pp2A_deact_CREB included
2: ARbeta-Gs binding included
MAPK_act_MKPtranscription included
PDEstar_deact_cAMP included
03: GRK activity included
Release of C2 included
MKP1 basal transcription included
reaction0 included
reaction3 included
MKP_decat_MAPKtyr included
RapRaf_act_MAPKKSer included
MKP1p turnover included
MKP1 dephosph included
MKP1p_deact_MAPKactive included
02b: Gs activation included
Rap1_binds_BRaf included
BRaf_act_MAPKK included
PP_deact_BRaf included
PKA_act_BRaf included
cAMP_binds_A2 included
GRK to cytosol included
08: Epac exchange included
Release of C1 included
Rap1raf_act_MAPKK included
MKP1 phospho by MAPKactive included
MKP1p turnover nucleus included
07: PDE included
MKP1p deact MAPKact included
MKP1 turnover in nucleus included
01b: isoprenaline binding included
PTPSL_dephos included
MAPKK_act_MAPK_thr included
Receptor recycling included
PKA_act_PDE included
PP2A_inact_MAPKK_active included
MAPK dephosph by PTP included
GRK-Gbg binding included
MKPp_decat_MAPKtyr included
PKA release by PKI included
8a: Rap1-Epac binding included
Epac-cAMP binding included
PKA_act_CREB included
PKA_deact_PTPSL included
MSK_act_CREB included
PDE_highKm deact cAMP included
MSK_dephos included
constit exch+hydrolysis included
MKP1p deact MAPKtyr included
PP1A_dephos_CREB included
MKP1 deact MAPKact included
14b: Gs trimerization included
MKP1 deact MAPKtyr included
reaction2 included
MKP1 turnover included
MKP2 deact MAPK tyr included
MKP1 phosph by MAPKactive_nucleus included
MKP1 dephosph in nucleus included
MKP1_deact_MAPKactive included
PKI translocation included
MKP1p translocation included
MAPK translocation included
MKP1 translocation included
MAPKactive_translocation included
PKA_translocation included
inhibited PKA export included
MKPRNA_export included

Simulations - Compart go to Specifications

Name
End Time
Output Options
1) MAPK phospho MSK Km 3000.0

KeepEvery 1

KeepAtMost 1000
1) MAPK phospho MSK kcat 3000.0

KeepEvery 1

KeepAtMost 1000
2) MSK dephospho 3000.0

KeepEvery 1

KeepAtMost 1000
3) PKA phospho CREB Km 3000.0

KeepEvery 1

KeepAtMost 1000
3) PKA phospho CREB kcat 3000.0

KeepEvery 1

KeepAtMost 1000
4) MSK phospho CREB Km 3000.0

KeepEvery 1

KeepAtMost 1000
4) MSK phospho CREB kcat 3000.0

KeepEvery 1

KeepAtMost 1000
5) PP2A dephosho CREB Km 3000.0

KeepEvery 1

KeepAtMost 1000
5) PP2A dephosho CREB kcat 3000.0

KeepEvery 1

KeepAtMost 1000
6) PP1A dephospho CREB Km 3000.0

KeepEvery 1

KeepAtMost 1000
6) PP1A dephospho CREB kcat 3000.0

KeepEvery 1

KeepAtMost 1000
7) MKP1 gene activation Km 3000.0

KeepEvery 1

KeepAtMost 1000
7) MKP1 gene activation kcat 3000.0

KeepEvery 1

KeepAtMost 1000
8) MKP1 basal transcription 3000.0

KeepEvery 1

KeepAtMost 1000
9) MAPK_act dephospho by MKP2 Km 3000.0

KeepEvery 1

KeepAtMost 1000
9) MAPK_act dephospho by MKP2 kcat 3000.0

KeepEvery 1

KeepAtMost 1000
10) MAPK_act dephospho by MKP1 Km 3000.0

KeepEvery 1

KeepAtMost 1000
10) MAPK_act dephospho by MKP1 kcat 3000.0

KeepEvery 1

KeepAtMost 1000
11) MAPK_act dephospho by MKP1* Km 3000.0

KeepEvery 1

KeepAtMost 1000
11) MAPK_act dephospho by MKP1* kcat 3000.0

KeepEvery 1

KeepAtMost 1000
12) MAPK_tyr dephospho by MKP2 Km 3000.0

KeepEvery 1

KeepAtMost 1000
12) MAPK_tyr dephospho by MKP2 kcat 3000.0

KeepEvery 1

KeepAtMost 1000
13) MAPK_tyr dephospho by MKP Km 3000.0

KeepEvery 1

KeepAtMost 1000
13) MAPK_tyr dephospho by MKP kcat 3000.0

KeepEvery 1

KeepAtMost 1000
14) MAPK_tyr dephospho by MKP1* Km 3000.0

KeepEvery 1

KeepAtMost 1000
14) MAPK_tyr dephospho by MKP1* kcat 3000.0

KeepEvery 1

KeepAtMost 1000
15) MKP1 phospho by MAPK Km 3000.0

KeepEvery 1

KeepAtMost 1000
15) MKP1 phospho by MAPK kcat 3000.0

KeepEvery 1

KeepAtMost 1000
16) MKP1* dephospho kf 3000.0

KeepEvery 1

KeepAtMost 1000
17) MKP1 turnover kf 3000.0

KeepEvery 1

KeepAtMost 1000
18) MKP1* turnover kf 3000.0

KeepEvery 1

KeepAtMost 1000
19) PKI + PKA kf 3000.0

KeepEvery 1

KeepAtMost 1000
19) PKI + PKA kr 3000.0

KeepEvery 1

KeepAtMost 1000
20) MKP1 translation kf 3000.0

KeepEvery 1

KeepAtMost 1000
21) MEK phospho by Braf* Km 3000.0

KeepEvery 1

KeepAtMost 1000
21) MEK phospho by Braf* kcat 3000.0

KeepEvery 1

KeepAtMost 1000
22) MEK_ser phospho by Braf* Km 3000.0

KeepEvery 1

KeepAtMost 1000
22) MEK_ser phospho by Braf* kcat 3000.0

KeepEvery 1

KeepAtMost 1000
23) MAPK phospho by MEK* Km 3000.0

KeepEvery 1

KeepAtMost 1000
23) MAPK phospho by MEK* kcat 3000.0

KeepEvery 1

KeepAtMost 1000
24) MAPK_tyr phospho by MEK* Km 3000.0

KeepEvery 1

KeepAtMost 1000
24) MAPK_tyr phospho by MEK* kcat 3000.0

KeepEvery 1

KeepAtMost 1000
25) cAMP degradation by PDE Km 3000.0

KeepEvery 1

KeepAtMost 1000
25) cAMP degradation by PDE kcat 3000.0

KeepEvery 1

KeepAtMost 1000
26) cAMP degradation by PDE* Km 3000.0

KeepEvery 1

KeepAtMost 1000
26) cAMP degradation by PDE* kcat 3000.0

KeepEvery 1

KeepAtMost 1000
27) cAMP degradation by PDE_high Km 3000.0

KeepEvery 1

KeepAtMost 1000
27) cAMP degradation by PDE_high kcat 3000.0

KeepEvery 1

KeepAtMost 1000
28) Braf phospho by PKA Km 3000.0

KeepEvery 1

KeepAtMost 1000
28) Braf phospho by PKA kcat 3000.0

KeepEvery 1

KeepAtMost 1000
29) Braf dephospho by PP2A Km 3000.0

KeepEvery 1

KeepAtMost 1000
29) Braf dephospho by PP2A kcat 3000.0

KeepEvery 1

KeepAtMost 1000
30) PTP phospho by PKA Km 3000.0

KeepEvery 1

KeepAtMost 1000
30) PTP phospho by PKA kcat 3000.0

KeepEvery 1

KeepAtMost 1000
31) PTP dephospho by PP1 Km 3000.0

KeepEvery 1

KeepAtMost 1000
31) PTP dephospho by PP1 kcat 3000.0

KeepEvery 1

KeepAtMost 1000
32) MEK* dephospho by PP2A Km 3000.0

KeepEvery 1

KeepAtMost 1000
32) MEK* dephospho by PP2A kcat 3000.0

KeepEvery 1

KeepAtMost 1000
33) MEK_ser dephospho by PP2A Km 3000.0

KeepEvery 1

KeepAtMost 1000
33) MEK_ser dephospho by PP2A kcat 3000.0

KeepEvery 1

KeepAtMost 1000
34) MAPK* dephospho by MKP1 Km 3000.0

KeepEvery 1

KeepAtMost 1000
34) MAPK* dephospho by MKP1 kcat 3000.0

KeepEvery 1

KeepAtMost 1000
35) MAPK_tyr dephospho by MKP1 Km 3000.0

KeepEvery 1

KeepAtMost 1000
35) MAPK_tyr dephospho by MKP1 kcat 3000.0

KeepEvery 1

KeepAtMost 1000
36) MAPK* dephospho by MKP1* Km 3000.0

KeepEvery 1

KeepAtMost 1000
36) MAPK* dephospho by MKP1* kcat 3000.0

KeepEvery 1

KeepAtMost 1000
37) MAPK_tyr dephospho by MKP1* Km 3000.0

KeepEvery 1

KeepAtMost 1000
37) MAPK_tyr dephospho by MKP1* kcat 3000.0

KeepEvery 1

KeepAtMost 1000
38) MAPK* dephospho by MKP2 Km 3000.0

KeepEvery 1

KeepAtMost 1000
38) MAPK* dephospho by MKP2 kcat 3000.0

KeepEvery 1

KeepAtMost 1000
39) MAPK_tyr dephospho by MKP2 Km 3000.0

KeepEvery 1

KeepAtMost 1000
39) MAPK_tyr dephospho by MKP2 kcat 3000.0

KeepEvery 1

KeepAtMost 1000
40) MAPK* dephospho by PTP Km 3000.0

KeepEvery 1

KeepAtMost 1000
40) MAPK* dephospho by PTP kcat 3000.0

KeepEvery 1

KeepAtMost 1000
41) MKP1 phospho by MAPK* cyto Km 3000.0

KeepEvery 1

KeepAtMost 1000
41) MKP1 phospho by MAPK* cyto kcat 3000.0

KeepEvery 1

KeepAtMost 1000
42) MKP1* dephospho cyto kf 3000.0

KeepEvery 1

KeepAtMost 1000
43) MKP1 degradation kf 3000.0

KeepEvery 1

KeepAtMost 1000
44) MKP1* degradation kf 3000.0

KeepEvery 1

KeepAtMost 1000
45) PDE phospho by PKA Km 3000.0

KeepEvery 1

KeepAtMost 1000
45) PDE phospho by PKA kcat 3000.0

KeepEvery 1

KeepAtMost 1000
46) PDE* dephospho Km 3000.0

KeepEvery 1

KeepAtMost 1000
46) PDE* dephospho kcat 3000.0

KeepEvery 1

KeepAtMost 1000
47) R2C2 1 kf 3000.0

KeepEvery 1

KeepAtMost 1000
47) R2C2 1 kr 3000.0

KeepEvery 1

KeepAtMost 1000
48) R2C2 2 kf 3000.0

KeepEvery 1

KeepAtMost 1000
48) R2C2 2 kr 3000.0

KeepEvery 1

KeepAtMost 1000
49) R2C2 3 kf 3000.0

KeepEvery 1

KeepAtMost 1000
49) R2C2 3 kr 3000.0

KeepEvery 1

KeepAtMost 1000
50) R2C2 4 kf 3000.0

KeepEvery 1

KeepAtMost 1000
50) R2C2 4 kr 3000.0

KeepEvery 1

KeepAtMost 1000
51) PKA release 1 kf 3000.0

KeepEvery 1

KeepAtMost 1000
51) PKA release 1 kr 3000.0

KeepEvery 1

KeepAtMost 1000
52) PKA release 2 kf 3000.0

KeepEvery 1

KeepAtMost 1000
52) PKA release 2 kr 3000.0

KeepEvery 1

KeepAtMost 1000
53) PKA release by PKI kf 3000.0

KeepEvery 1

KeepAtMost 1000
54) EPAC activated by cAMP kf 3000.0

KeepEvery 1

KeepAtMost 1000
54) EPAC activated by cAMP kr 3000.0

KeepEvery 1

KeepAtMost 1000
55) MEK phospho by RapRaf Km 3000.0

KeepEvery 1

KeepAtMost 1000
55) MEK phospho by RapRaf kcat 3000.0

KeepEvery 1

KeepAtMost 1000
56) MEK_ser phospho by RapRaf Km 3000.0

KeepEvery 1

KeepAtMost 1000
56) MEK_ser phospho by RapRaf kcat 3000.0

KeepEvery 1

KeepAtMost 1000
57) Braf activation by Rap kf 3000.0

KeepEvery 1

KeepAtMost 1000
57) Braf activation by Rap kr 3000.0

KeepEvery 1

KeepAtMost 1000
58) RapGDP - RapGTP kf 3000.0

KeepEvery 1

KeepAtMost 1000
58) RapGDP - RapGTP kr 3000.0

KeepEvery 1

KeepAtMost 1000
59) Rap1 activation by EPAC step 1 3000.0

KeepEvery 1

KeepAtMost 1000
59) Rap1 activation by EPAC step 2 3000.0

KeepEvery 1

KeepAtMost 1000
60) Rap1 activation by EPAC step 3 3000.0

KeepEvery 1

KeepAtMost 1000
61) Rap1 deactivation step 1 3000.0

KeepEvery 1

KeepAtMost 1000
61) Rap1 deactivation step 2 3000.0

KeepEvery 1

KeepAtMost 1000
62) Rap1 deactivation step 3 3000.0

KeepEvery 1

KeepAtMost 1000
63) cAMP production Km 3000.0

KeepEvery 1

KeepAtMost 1000
63) cAMP production kcat 3000.0

KeepEvery 1

KeepAtMost 1000
64) BAR phosphorylation Km 3000.0

KeepEvery 1

KeepAtMost 1000
64) BAR phosphorylation kcat 3000.0

KeepEvery 1

KeepAtMost 1000
65) BAR activation by ISO kf 3000.0

KeepEvery 1

KeepAtMost 1000
65) BAR activation by ISO kr 3000.0

KeepEvery 1

KeepAtMost 1000
66) Gtrimer binds to BAR kf 3000.0

KeepEvery 1

KeepAtMost 1000
66) Gtrimer binds to BAR kr 3000.0

KeepEvery 1

KeepAtMost 1000
67) Gprotein activation kf 3000.0

KeepEvery 1

KeepAtMost 1000
67) Gprotein activation kr 3000.0

KeepEvery 1

KeepAtMost 1000
68) GRK recruitment by Gbg kf 3000.0

KeepEvery 1

KeepAtMost 1000
68) GRK recruitment by Gbg kr 3000.0

KeepEvery 1

KeepAtMost 1000
69) GRK on membrane kf 3000.0

KeepEvery 1

KeepAtMost 1000
69) GRK on membrane kr 3000.0

KeepEvery 1

KeepAtMost 1000
70) GRK to cytosol kf 3000.0

KeepEvery 1

KeepAtMost 1000
71) AC activation kf 3000.0

KeepEvery 1

KeepAtMost 1000
71) AC activation kr 3000.0

KeepEvery 1

KeepAtMost 1000
72) Gs deactivation kf 3000.0

KeepEvery 1

KeepAtMost 1000
73) G trimerization kf 3000.0

KeepEvery 1

KeepAtMost 1000
74) BAR recycling kf 3000.0

KeepEvery 1

KeepAtMost 1000
MAPK* import 3000.0

KeepEvery 1

KeepAtMost 1000
MAPK* export 3000.0

KeepEvery 1

KeepAtMost 1000
MAPK import 3000.0

KeepEvery 1

KeepAtMost 1000
MAPK export 3000.0

KeepEvery 1

KeepAtMost 1000
PKA import 3000.0

KeepEvery 1

KeepAtMost 1000
PKA export 3000.0

KeepEvery 1

KeepAtMost 1000
PKI.PKA export 3000.0

KeepEvery 1

KeepAtMost 1000
PKI import 3000.0

KeepEvery 1

KeepAtMost 1000
MKP1 mRNA export 3000.0

KeepEvery 1

KeepAtMost 1000
MKP1 import 3000.0

KeepEvery 1

KeepAtMost 1000
MKP1 export 3000.0

KeepEvery 1

KeepAtMost 1000
MKP1* import 3000.0

KeepEvery 1

KeepAtMost 1000
MKP1* export 3000.0

KeepEvery 1

KeepAtMost 1000
Iso 3000.0

KeepEvery 1

KeepAtMost 1000
BAR 3000.0

KeepEvery 1

KeepAtMost 1000
Gs trimer 3000.0

KeepEvery 1

KeepAtMost 1000
AC 3000.0

KeepEvery 1

KeepAtMost 1000
MAPK 3000.0

KeepEvery 1

KeepAtMost 1000
R2C2 3000.0

KeepEvery 1

KeepAtMost 1000
ATP 3000.0

KeepEvery 1

KeepAtMost 1000
MKP1 3000.0

KeepEvery 1

KeepAtMost 1000
bRaf 3000.0

KeepEvery 1

KeepAtMost 1000
Rap1GAP 3000.0

KeepEvery 1

KeepAtMost 1000
MEK 3000.0

KeepEvery 1

KeepAtMost 1000
EPAC 3000.0

KeepEvery 1

KeepAtMost 1000
PTP 3000.0

KeepEvery 1

KeepAtMost 1000
PP2A 3000.0

KeepEvery 1

KeepAtMost 1000
GRK 3000.0

KeepEvery 1

KeepAtMost 1000
PDE 3000.0

KeepEvery 1

KeepAtMost 1000
MKP2 3000.0

KeepEvery 1

KeepAtMost 1000
Rap1GDP 3000.0

KeepEvery 1

KeepAtMost 1000
MSK 3000.0

KeepEvery 1

KeepAtMost 1000
PP1A 3000.0

KeepEvery 1

KeepAtMost 1000
MKP1 DNA 3000.0

KeepEvery 1

KeepAtMost 1000
PP2A nucleus 3000.0

KeepEvery 1

KeepAtMost 1000
CREB 3000.0

KeepEvery 1

KeepAtMost 1000

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Assignments

Name Variable Assignment Function Expression

Events

Name Trigger Type Variable Assignment

Geometry non-spatial1212631236

(Origin: 0.0, 0.0, 0.0; Extent: 10.0, 10.0, 10.0 [um])

Dimension Type Subdomain Adjacent Subvolumes Size Mapped Compartment
Compartmental Compartment nuclear membrane

Events

Name Variable Rate Expression

Global Parameters

Name
Expression
kimportPKI 0.001[um.s-1]
Km_Rap1BRaf 0.5[uM]
kcat_Rap1Braf 0.105[s-1]

Universal ID's

Text Annotations

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Downloads

Model Format
Model Downloads
Virtual Cell Markup Language VCML File
PDF Report Report
COMBINE Archive OMEX File
SEDML SEDML File
File Format
Application Downloads
BNGL Compart.bngl
SBML Compart.sbml
Matlab Compart.m
NFSim XML Compart.xml