Reaction Diagram
Physiology
| Universal ID's | Text Annotations |
|---|---|
|
|
|
| Reaction |
Name
Structure
|
Kinetics | Depiction |
|---|---|---|---|
| X_CMX_CM+X_CM |
r2
CM
|
GeneralKinetics | X_CMX_CM+X_CM |
|
|
|
reaction rate (J): (0.04 + (0.4 * N_CM) + (2.0 * X_CM * X_CM / (1.0 + (X_CM * X_CM))) - (0.4 * X_CM * Y_CM) + (0.008 * X_CM * S_CM))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] |
|
| Y_CMY_CM+Y_CM |
r3
CM
|
GeneralKinetics | Y_CMY_CM+Y_CM |
|
|
|
reaction rate (J): ((0.4 * X_CM) - (0.028 * Y_CM))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] |
|
| L_sourceL_EC |
rx
EC
|
GeneralKinetics | L_sourceL_EC |
|
|
|
reaction rate (J): ((kf * L_source) - (kr * L_EC))[uM.s-1]
user defined (kr): 1.0[s-1] user defined (kf): 10.0[s-1] |
|
| L_EC+R_CMS_CM |
r1
CM
|
GeneralKinetics | L_EC+R_CMS_CM |
|
|
|
reaction rate (J): ((kf * L_EC * R_CM) - (kr * S_CM))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] user defined (kr): 1.0[s-1] user defined (kf): 2.0[s-1.uM-1] |
| Name |
Type
Electrical (Membrane Polarity)
|
|---|---|
| IC |
Compartment
(+) (-)
|
|
|
|
| EC |
Compartment
(+) (-)
|
|
|
|
| CM |
Membrane
N/A
|
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|
|
| Name | Structure | BioNetGen Definition |
|---|---|---|
| L_EC | EC | |
|
|
|
|
| L_source | EC | |
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|
|
|
| N_CM | CM | |
|
|
|
|
| Y_CM | CM | |
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|
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| X_CM | CM | |
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|
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| S_CM | CM | |
|
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| R_CM | CM | |
|
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|
| Name | Text Annotations | BioNetGen Definition |
|---|
| Name |
Type
Count
|
BioNetGen Definition |
|---|
Applications
| Name | Math Type | Annotation |
|---|---|---|
| Needle | Deterministic (ODE) Spatial (3D) |
Application - Needle
| Species | Initial Condition | Diffusion Constant | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| L_EC | 0.0 [uM] | 15.0
[um2/s] | L_source |
(((( - 5.0 + x) * ( - 5.0 + x)) + (( - 5.0 + y) * ( - 5.0 + y)) + (( - 2.5 + z) * ( - 2.5 + z))) < 1.0)
[uM]
|
10.0
[um2/s] | N_CM |
(0.2 * ((t >= 15.0) && (t <= 16.0)))
[uM]
|
0.1
[um2/s] | Y_CM |
2.0
[uM]
|
0.0
[um2/s] | X_CM |
0.14
[uM]
|
0.0
[um2/s] | S_CM |
0.0
[uM]
|
0.0
[um2/s] | R_CM |
100.0
[uM]
|
0.0
[um2/s]
|
|
| Name | Reaction Mapping |
|---|---|
| r2 | included |
| r3 | included |
| rx | included |
| r1 | included |
| Name | End Time | Output Options |
|---|---|---|
| Simulation0 | 100.0 [s] |
OutputTimeStep 1.0 |
| Dimension | Type | Subdomain | Adjacent Subvolumes | Size | Mapped Compartment |
|---|---|---|---|---|---|
| Volume | Analytical | IC | 11.821125 [um3] | IC | |
| Volume | Analytical | EC | 113.17887499999999 [um3] | EC | |
| Surface | EC_IC_membrane | EC | IC | 25.03574790171551 [um2] | CM |
Global Parameters
| Name | Expression |
|---|