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Name - fXii_activation

BioModel ID - 84069156

Reaction Diagram

reactionDiagram

Physiology

Universal ID's	Text Annotations

Reactions See in Dashboard
Reaction	Name Structure	Kinetics	Depiction
fXiibfXiiba	fXii surface activation Membrane0	MassAction	fXiibfXiiba
		reaction rate (J): ((Kf * fXiib) - (Kr * fXiiba))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 1.0[s-1] reverse rate constant (Kr): 0.0[s-1]
fXiiba+fXiibafXiiba+fXiib	fXii autoinhibition Membrane0	MassAction	fXiiba+fXiibafXiiba+fXiib
		reaction rate (J): (((Kf * fXiiba) * fXiiba) - ((Kr * fXiiba) * fXiib))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 0.1[um2.s-1.molecules-1] reverse rate constant (Kr): 0.0[um2.s-1.molecules-1]
fXiifXiib	fXii binding Membrane0	MassAction	fXiifXiib
		reaction rate (J): ((Kf * fXii) - (Kr * fXiib))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 0.28[molecules.um-2.s-1.uM-1] reverse rate constant (Kr): 0.01[s-1]
fXiibafXiia	fXiai release Membrane0	MassAction	fXiibafXiia
		reaction rate (J): ((Kf * fXiiba) - (Kr * fXiia))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 0.0[s-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-1]

Structures See in Dashboard
Name	Type Electrical (Membrane Polarity)
c1	Compartment (+) (-)

c0	Compartment (+) (-)

Membrane0	Membrane N/A

Species See in Dashboard
Name	Structure	BioNetGen Definition
C1	c0

fXiib	Membrane0

fXiia	c0

fXiiba	Membrane0

fXii	c0

Molecules See in Dashboard
Name	Text Annotations	BioNetGen Definition

Observables See in Dashboard
Name	Type Count	BioNetGen Definition

Applications

Applications See in Dashboard
Name	Math Type	Annotation
Application0	Deterministic (ODE) Spatial (2D)

Application - Application0

Specifications(Species) - Application0 See in Dashboard
Species	Initial Condition	Diffusion Constant
C1	0.0 [uM]	10.0 [um2/s]
fXiia	0.0 [uM]	10.0 [um2/s]
fXii	0.09 [uM]	10.0 [um2/s]
fXiib	0.0 [uM]	0.1 [um2/s]
fXiiba	0.0 [uM]	0.1 [um2/s]

Specifications(Reaction) - Application0 See in Dashboard
Name	Reaction Mapping
fXii surface activation	included
fXii autoinhibition	included
fXii binding	included
fXiai release	included

Simulations - Application0 See in Dashboard
Name	End Time	Output Options
Simulation0	1600.0 [s]	OutputTimeStep 15.0

Geometry Geometry1877367473 See in Dashboard
(Origin: -10.0, -12.5, 0.0; Extent: 20.0, 25.0, 10.0[um])
Dimension	Type	Subdomain	Adjacent Subvolumes	Size	Mapped Compartment
Volume	Analytical	subdomain1		5.4 [um2]	c1
Volume	Analytical	subdomain0		494.6 [um2]	c0
Surface		subdomain0_subdomain1_membrane	subdomain0 \| subdomain1	9.146486470695088 [um]	Membrane0

Global Parameters

Global Parameters See in Dashboard
Name	Expression