Reaction Diagram
Physiology
Universal ID's | Text Annotations |
---|---|
|
|
Reaction |
Name
Structure
|
Kinetics | Depiction |
---|---|---|---|
SHC_p_cytoSHC_cyto |
SHC dephosphorylation
cyto
|
MassAction | SHC_p_cytoSHC_cyto |
|
|
reaction rate (J): ((Kf * SHC_p_cyto) - (Kr * SHC_cyto))[uM.s-1]
forward rate constant (Kf): 0.001[s-1] reverse rate constant (Kr): 0.0[s-1] |
|
MEK_cytoMEK_active_cyto |
MEk activation
cyto
|
HMMIrreversible | MEK_cytoMEK_active_cyto |
|
|
reaction rate (J): ((Vmax * MEK_cyto) / (Km + MEK_cyto))[uM.s-1]
Km (1/2 max) (Km): 0.1591[uM] max reaction rate (Vmax): (0.105 * Raf_active_cyto)[uM.s-1] |
|
MAPK_active_cytoMAPK_active_N_nucleus |
nuclear transport
nuclear Membrane
|
MassAction | MAPK_active_cytoMAPK_active_N_nucleus |
|
|
reaction rate (J): ((Kf * MAPK_active_cyto) - (Kr * MAPK_active_N_nucleus))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): kf[molecules.um-2.s-1.uM-1] reverse rate constant (Kr): kr[molecules.um-2.s-1.uM-1] user defined (kf): 0.13[s-1] user defined (kr): 0.012[s-1] |
|
EGFR_cyto_mem+EGF_extraEGFR_active |
receptor ligand binding
cyto_mem
|
MassAction | EGFR_cyto_mem+EGF_extraEGFR_active |
|
|
reaction rate (J): (((Kf * EGFR_cyto_mem) * EGF_extra) - (Kr * EGFR_active))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 30.0[s-1.uM-1] reverse rate constant (Kr): 0.038[s-1] |
|
Ras_GDP_cyto_memRas_GTP_cyto_mem |
Ras activation by Sos
cyto_mem
|
HMMIrreversible | Ras_GDP_cyto_memRas_GTP_cyto_mem |
|
|
reaction rate (J): ((Vmax * Ras_GDP_cyto_mem) / (Km + Ras_GDP_cyto_mem))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] Km (1/2 max) (Km): 0.5[molecules.um-2] max reaction rate (Vmax): (kcat * EGFR_Sos_Grb2_Shc_cyto_mem)[molecules.um-2.s-1] user defined (kcat): 0.01[s-1] |
|
MAPK_active_cytoMAPK_cyto |
MAPK inactivation
cyto
|
HMMIrreversible | MAPK_active_cytoMAPK_cyto |
|
|
reaction rate (J): ((Vmax * MAPK_active_cyto) / (Km + MAPK_active_cyto))[uM.s-1]
Km (1/2 max) (Km): 0.77[uM] max reaction rate (Vmax): (kcat * PP2A_cyto)[uM.s-1] user defined (kcat): 0.636[s-1] |
|
MAPK_cytoMAPK_active_cyto |
MAPK activation
cyto
|
HMMIrreversible | MAPK_cytoMAPK_active_cyto |
|
|
reaction rate (J): ((Vmax * MAPK_cyto) / (Km + MAPK_cyto))[uM.s-1]
Km (1/2 max) (Km): 0.1591[uM] max reaction rate (Vmax): (0.01 * Raf_active_cyto)[uM.s-1] |
|
PP2A_inactivePP2A_cyto |
r0
cyto
|
MassAction | PP2A_inactivePP2A_cyto |
|
|
reaction rate (J): ((Kf * PP2A_inactive) - (Kr * PP2A_cyto))[uM.s-1]
forward rate constant (Kf): 0.001[s-1] reverse rate constant (Kr): 0.001[s-1] |
|
Raf_active_cytoRaf_cyto |
Raf inactivation
cyto
|
HMMIrreversible | Raf_active_cytoRaf_cyto |
|
|
reaction rate (J): ((Vmax * Raf_active_cyto) / (Km + Raf_active_cyto))[uM.s-1]
Km (1/2 max) (Km): 15.7[uM] max reaction rate (Vmax): (kcat * PP2A_cyto)[uM.s-1] user defined (kcat): 5.0[s-1] |
|
Ras_GTP_cyto_memRas_GDP_cyto_mem |
Ras GAP
cyto_mem
|
HMMIrreversible | Ras_GTP_cyto_memRas_GDP_cyto_mem |
|
|
reaction rate (J): ((Vmax * Ras_GTP_cyto_mem) / (Km + Ras_GTP_cyto_mem))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] Km (1/2 max) (Km): 1.0[molecules.um-2] max reaction rate (Vmax): (kcat * Ras_GAP_cyto)[molecules.um-2.s-1] user defined (kcat): 0.01[s-1] |
|
Raf_cytoRaf_active_cyto |
Raf activation
cyto_mem
|
HMMIrreversible | Raf_cytoRaf_active_cyto |
|
|
reaction rate (J): ((Vmax * Raf_cyto) / (Km + Raf_cyto))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] Km (1/2 max) (Km): 2.0[uM] max reaction rate (Vmax): (kcat * Ras_GTP_cyto_mem)[molecules.um-2.s-1] user defined (kcat): 0.01[1.0E-15 mol.item-1.m-1.s-1] |
|
MEK_active_cytoMEK_cyto |
MEK inactivation
cyto
|
HMMIrreversible | MEK_active_cytoMEK_cyto |
|
|
reaction rate (J): ((Vmax * MEK_active_cyto) / (Km + MEK_active_cyto))[uM.s-1]
Km (1/2 max) (Km): 15.7[uM] max reaction rate (Vmax): (kcat * PP2A_cyto)[uM.s-1] user defined (kcat): 5.0[s-1] |
|
EGFR_GAP_Grb2+Sos_cytoEGFR_GAP_GRb2_Sos |
Sos binding
cyto_mem
|
MassAction | EGFR_GAP_Grb2+Sos_cytoEGFR_GAP_GRb2_Sos |
|
|
reaction rate (J): (((Kf * EGFR_GAP_Grb2) * Sos_cyto) - (Kr * EGFR_GAP_GRb2_Sos))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 1.66[s-1.uM-1] reverse rate constant (Kr): 0.06[s-1] |
|
SHC_cytoSHC_p_cyto |
Shc phosphorylation
cyto_mem
|
HMMIrreversible | SHC_cytoSHC_p_cyto |
|
|
reaction rate (J): ((Vmax * SHC_cyto) / (Km + SHC_cyto))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] Km (1/2 max) (Km): 1.0[uM] max reaction rate (Vmax): (0.1 * EGFR_GAP_GRb2_Sos)[molecules.um-2.s-1] |
|
GAP+EGFR_dimerEGFR_GAP |
GAP binding
cyto_mem
|
MassAction | GAP+EGFR_dimerEGFR_GAP |
|
|
reaction rate (J): (((Kf * GAP) * EGFR_dimer) - (Kr * EGFR_GAP))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 1.0[s-1.uM-1] reverse rate constant (Kr): 0.001[s-1] |
|
SHC_p_cyto+EGFR_GAP_GRb2_SosEGFR_Sos_Grb2_Shc_cyto_mem |
Shc binding EGFR
cyto_mem
|
MassAction | SHC_p_cyto+EGFR_GAP_GRb2_SosEGFR_Sos_Grb2_Shc_cyto_mem |
|
|
reaction rate (J): (((Kf * SHC_p_cyto) * EGFR_GAP_GRb2_Sos) - (Kr * EGFR_Sos_Grb2_Shc_cyto_mem))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 1.0[s-1.uM-1] reverse rate constant (Kr): 0.001[s-1] |
|
EGFR_activeEGFR_dimer |
dimerization
cyto_mem
|
MassAction | EGFR_activeEGFR_dimer |
|
|
reaction rate (J): ((Kf * pow(EGFR_active,2.0)) - (Kr * EGFR_dimer))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 1.0[um2.s-1.molecules-1] reverse rate constant (Kr): 0.1[s-1] |
|
EGFR_GAP+Grb2_cytoEGFR_GAP_Grb2 |
GRb2 binding
cyto_mem
|
MassAction | EGFR_GAP+Grb2_cytoEGFR_GAP_Grb2 |
|
|
reaction rate (J): (((Kf * EGFR_GAP) * Grb2_cyto) - (Kr * EGFR_GAP_Grb2))[molecules.um-2.s-1]
inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 0.0[1] forward rate constant (Kf): 0.166[s-1.uM-1] reverse rate constant (Kr): 0.0[s-1] |
Name |
Type
Electrical (Membrane Polarity)
|
---|---|
extra |
Compartment
(+) (-)
|
|
|
nucleus |
Compartment
(+) (-)
|
|
|
cyto |
Compartment
(+) (-)
|
|
|
cyto_mem |
Membrane
N/A
|
|
|
nuclear Membrane |
Membrane
N/A
|
|
|
Name | Structure | BioNetGen Definition |
---|---|---|
MAPK_active_N_nucleus | nucleus | |
|
|
|
Raf_active_cyto | cyto | |
|
|
|
ATP | cyto | |
|
|
|
EGFR_active | cyto_mem | |
|
|
|
GAP | cyto | |
|
|
|
EGFR_GAP | cyto_mem | |
|
|
|
MEK_cyto | cyto | |
|
|
|
MAPK_active_cyto | cyto | |
|
|
|
EGFR_cyto_mem | cyto_mem | |
|
|
|
EGFR_dimer | cyto_mem | |
|
|
|
Ras_GDP_cyto_mem | cyto_mem | |
|
|
|
Ras_GAP_cyto | cyto | |
|
|
|
MEK_active_cyto | cyto | |
|
|
|
MAPK_cyto | cyto | |
|
|
|
EGF_extra | extra | |
|
|
|
Sos_cyto | cyto | |
|
|
|
SHC_p_cyto | cyto | |
|
|
|
Ras_GTP_cyto_mem | cyto_mem | |
|
|
|
SHC_cyto | cyto | |
|
|
|
EGFR_GAP_GRb2_Sos | cyto_mem | |
|
|
|
Raf_cyto | cyto | |
|
|
|
EGFR_Sos_Grb2_Shc_cyto_mem | cyto_mem | |
|
|
|
Grb2_cyto | cyto | |
|
|
|
PP2A_cyto | cyto | |
|
|
|
EGFR_GAP_Grb2 | cyto_mem | |
|
|
|
PP2A_inactive | cyto | |
|
|
Name | Text Annotations | BioNetGen Definition |
---|
Name |
Type
Count
|
BioNetGen Definition |
---|
Applications
Name | Math Type | Annotation |
---|---|---|
compartmental | Deterministic (ODE) Compartmental | |
ellipse_0999 receptor activation only | Deterministic (ODE) Spatial (2D) | (copied from ellipse_0999) (copied from compartmental) |
circle | Deterministic (ODE) Spatial (2D) | (copied from ellipse_0999 receptor activation only) (copied from ellipse_0999) (copied from compartmental) |
ellipse_099_nucleus1_1 | Deterministic (ODE) Spatial (2D) | (copied from ellipse_0999 receptor activation only) (copied from ellipse_0999) (copied from compartmental) |
ellipse_099_nucleus3_1 | Deterministic (ODE) Spatial (2D) | (copied from ellipse_099_nucleus1_1) (copied from ellipse_0999 receptor activation only) (copied from ellipse_0999) (copied from compartmental) |
ellipse_099_nucleus5_1 | Deterministic (ODE) Spatial (2D) | (copied from ellipse_099_nucleus3_1) (copied from ellipse_099_nucleus1_1) (copied from ellipse_0999 receptor activation only) (copied from ellipse_0999) (copied from compartmental) |
spatially varying diffusion and receptor number | Deterministic (ODE) Spatial (2D) | (copied from ellipse_0999 receptor activation only) (copied from ellipse_0999) (copied from compartmental) |
circle fine mesh | Deterministic (ODE) Spatial (2D) | (copied from circle) (copied from ellipse_0999 receptor activation only) (copied from ellipse_0999) (copied from compartmental) |
ellipse fine mesh | Deterministic (ODE) Spatial (2D) | (copied from ellipse_099_nucleus5_1) (copied from ellipse_099_nucleus3_1) (copied from ellipse_099_nucleus1_1) (copied from ellipse_0999 receptor activation only) (copied from ellipse_0999) (copied from compartmental) |
Application - compartmental
Species | Initial Condition | Diffusion Constant | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
EGF_extra | 1.0 [uM] | 0.0
[um2/s] MAPK_active_N_nucleus |
0.0
[uM]
|
0.0
[um2/s] | Raf_active_cyto |
0.0
[uM]
|
0.0
[um2/s] | ATP |
5000.0
[uM]
|
0.0
[um2/s] | GAP |
0.1
[uM]
|
0.0
[um2/s] | MEK_cyto |
0.18
[uM]
|
0.0
[um2/s] | MAPK_active_cyto |
0.0
[uM]
|
0.0
[um2/s] | Ras_GAP_cyto |
0.002
[uM]
|
0.0
[um2/s] | MEK_active_cyto |
0.0
[uM]
|
0.0
[um2/s] | MAPK_cyto |
0.36
[uM]
|
0.0
[um2/s] | Sos_cyto |
0.1
[uM]
|
0.0
[um2/s] | SHC_p_cyto |
0.0
[uM]
|
0.0
[um2/s] | SHC_cyto |
0.5
[uM]
|
0.0
[um2/s] | Raf_cyto |
0.2
[uM]
|
0.0
[um2/s] | Grb2_cyto |
1.0
[uM]
|
0.0
[um2/s] | PP2A_cyto |
0.0
[uM]
|
0.0
[um2/s] | PP2A_inactive |
0.1
[uM]
|
0.0
[um2/s] | EGFR_active |
0.0
[uM]
|
0.0
[um2/s] | EGFR_GAP |
0.0
[uM]
|
0.0
[um2/s] | EGFR_cyto_mem |
400.0
[uM]
|
0.0
[um2/s] | EGFR_dimer |
0.0
[uM]
|
0.0
[um2/s] | Ras_GDP_cyto_mem |
500.0
[uM]
|
0.0
[um2/s] | Ras_GTP_cyto_mem |
0.0
[uM]
|
0.0
[um2/s] | EGFR_GAP_GRb2_Sos |
0.0
[uM]
|
0.0
[um2/s] | EGFR_Sos_Grb2_Shc_cyto_mem |
0.0
[uM]
|
0.0
[um2/s] | EGFR_GAP_Grb2 |
0.0
[uM]
|
0.0
[um2/s]
|
|
Name | Reaction Mapping |
---|---|
SHC dephosphorylation | included |
MEk activation | included |
nuclear transport | included |
receptor ligand binding | included |
Ras activation by Sos | included |
MAPK inactivation | included |
MAPK activation | included |
r0 | included |
Raf inactivation | included |
Ras GAP | included |
Raf activation | included |
MEK inactivation | included |
Sos binding | included |
Shc phosphorylation | included |
GAP binding | included |
Shc binding EGFR | included |
dimerization | included |
GRb2 binding | included |
Name | End Time | Output Options |
---|---|---|
Simulation0 | 3600.0 [s] |
OutputTimeStep 10.0 |
Simulation13 | 1.0 [s] |
OutputTimeStep 10.0 |
Dimension | Type | Subdomain | Adjacent Subvolumes | Size | Mapped Compartment |
---|---|---|---|---|---|
Compartmental | Compartment | nuclear Membrane |
Application - ellipse_0999 receptor activation only
Species | Initial Condition | Diffusion Constant | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
EGF_extra | 1.0 [uM] | 1.0
[um2/s] MAPK_active_N_nucleus |
0.0
[uM]
|
7.0
[um2/s] | Raf_active_cyto |
0.0
[uM]
|
7.0
[um2/s] | ATP |
5000.0
[uM]
|
10.0
[um2/s] | GAP |
0.1
[uM]
|
10.0
[um2/s] | MEK_cyto |
0.18
[uM]
|
6.0
[um2/s] | MAPK_active_cyto |
0.0
[uM]
|
7.0
[um2/s] | Ras_GAP_cyto |
0.002
[uM]
|
4.14
[um2/s] | MEK_active_cyto |
0.0
[uM]
|
6.0
[um2/s] | MAPK_cyto |
0.36
[uM]
|
7.0
[um2/s] | Sos_cyto |
1.0
[uM]
|
3.7
[um2/s] | SHC_p_cyto |
0.0
[uM]
|
6.4
[um2/s] | SHC_cyto |
1.0
[uM]
|
6.4
[um2/s] | Raf_cyto |
0.2
[uM]
|
7.0
[um2/s] | Grb2_cyto |
1.0
[uM]
|
8.5
[um2/s] | PP2A_cyto |
0.0
[uM]
|
0.0
[um2/s] | PP2A_inactive |
0.05
[uM]
|
0.0
[um2/s] | EGFR_active |
0.0
[uM]
|
0.0
[um2/s] | EGFR_GAP |
0.0
[uM]
|
0.08
[um2/s] | EGFR_cyto_mem |
400.0
[uM]
|
0.112
[um2/s] | EGFR_dimer |
0.0
[uM]
|
0.08
[um2/s] | Ras_GDP_cyto_mem |
500.0
[uM]
|
0.16
[um2/s] | Ras_GTP_cyto_mem |
0.0
[uM]
|
0.16
[um2/s] | EGFR_GAP_GRb2_Sos |
0.0
[uM]
|
0.0
[um2/s] | EGFR_Sos_Grb2_Shc_cyto_mem |
0.0
[uM]
|
0.08
[um2/s] | EGFR_GAP_Grb2 |
0.0
[uM]
|
0.0
[um2/s]
|
|
Name | Reaction Mapping |
---|---|
SHC dephosphorylation | included |
MEk activation | included |
nuclear transport | included |
receptor ligand binding | included |
Ras activation by Sos | included |
MAPK inactivation | included |
MAPK activation | included |
r0 | included |
Raf inactivation | included |
Ras GAP | included |
Raf activation | included |
MEK inactivation | included |
Sos binding | included |
Shc phosphorylation | included |
GAP binding | included |
Shc binding EGFR | included |
dimerization | included |
GRb2 binding | included |
Name | End Time | Output Options |
---|---|---|
Simulation12 | 60.0 [s] |
OutputTimeStep 10.0 |
Copy of Simulation12 1 | 3600.0 [s] |
OutputTimeStep 10.0 |
Copy of Copy of Simulation12 1 | 7200.0 [s] |
OutputTimeStep 10.0 |
varying diffusion of EGFR | 3600.0 [s] |
OutputTimeStep 10.0 |
varying receptor density | 3600.0 [s] |
OutputTimeStep 10.0 |
Dimension | Type | Subdomain | Adjacent Subvolumes | Size | Mapped Compartment |
---|---|---|---|---|---|
Volume | Analytical | nucleus | 11.673486088379706 [um2] | nucleus | |
Volume | Analytical | cell | 158.12602291325695 [um2] | cyto | |
Volume | Analytical | ECM | 190.20049099836334 [um2] | extra | |
Surface | ECM_cell_membrane | ECM | cell | 109.6318051248791 [um] | cyto_mem | |
Surface | cell_nucleus_membrane | cell | nucleus | 37.823588052652646 [um] | nuclear Membrane |
Application - circle
Species | Initial Condition | Diffusion Constant | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
EGF_extra | 1.0 [uM] | 1.0
[um2/s] MAPK_active_N_nucleus |
0.0
[uM]
|
7.0
[um2/s] | Raf_active_cyto |
0.0
[uM]
|
7.0
[um2/s] | ATP |
5000.0
[uM]
|
10.0
[um2/s] | GAP |
0.1
[uM]
|
10.0
[um2/s] | MEK_cyto |
0.18
[uM]
|
6.0
[um2/s] | MAPK_active_cyto |
0.0
[uM]
|
7.0
[um2/s] | Ras_GAP_cyto |
0.002
[uM]
|
4.14
[um2/s] | MEK_active_cyto |
0.0
[uM]
|
6.0
[um2/s] | MAPK_cyto |
0.36
[uM]
|
7.0
[um2/s] | Sos_cyto |
1.0
[uM]
|
10.0
[um2/s] | SHC_p_cyto |
0.0
[uM]
|
6.4
[um2/s] | SHC_cyto |
1.0
[uM]
|
6.4
[um2/s] | Raf_cyto |
0.2
[uM]
|
7.0
[um2/s] | Grb2_cyto |
1.0
[uM]
|
8.5
[um2/s] | PP2A_cyto |
0.0
[uM]
|
0.0
[um2/s] | PP2A_inactive |
0.05
[uM]
|
0.0
[um2/s] | EGFR_active |
0.0
[uM]
|
0.0
[um2/s] | EGFR_GAP |
0.0
[uM]
|
0.08
[um2/s] | EGFR_cyto_mem |
400.0
[uM]
|
0.04
[um2/s] | EGFR_dimer |
0.0
[uM]
|
0.08
[um2/s] | Ras_GDP_cyto_mem |
500.0
[uM]
|
0.16
[um2/s] | Ras_GTP_cyto_mem |
0.0
[uM]
|
0.16
[um2/s] | EGFR_GAP_GRb2_Sos |
0.0
[uM]
|
0.0
[um2/s] | EGFR_Sos_Grb2_Shc_cyto_mem |
0.0
[uM]
|
0.08
[um2/s] | EGFR_GAP_Grb2 |
0.0
[uM]
|
0.0
[um2/s]
|
|
Name | Reaction Mapping |
---|---|
SHC dephosphorylation | included |
MEk activation | included |
nuclear transport | included |
receptor ligand binding | included |
Ras activation by Sos | included |
MAPK inactivation | included |
MAPK activation | included |
r0 | included |
Raf inactivation | included |
Ras GAP | included |
Raf activation | included |
MEK inactivation | included |
Sos binding | included |
Shc phosphorylation | included |
GAP binding | included |
Shc binding EGFR | included |
dimerization | included |
GRb2 binding | included |
Name | End Time | Output Options |
---|---|---|
Simulation1 | 480.0 [s] |
OutputTimeStep 10.0 |
Simulation2 | 7200.0 [s] |
OutputTimeStep 10.0 |
Copy of Simulation1 | 60.0 [s] |
OutputTimeStep 10.0 |
Dimension | Type | Subdomain | Adjacent Subvolumes | Size | Mapped Compartment |
---|---|---|---|---|---|
Volume | Analytical | nucleus | 12.313600000000001 [um2] | nucleus | |
Volume | Analytical | cyto | 156.97920000000002 [um2] | cyto | |
Volume | Analytical | ecm | 86.7072 [um2] | extra | |
Surface | cyto_ecm_membrane | cyto | ecm | 46.21278101811295 [um] | cyto_mem | |
Surface | cyto_nucleus_membrane | cyto | nucleus | 12.415157207294083 [um] | nuclear Membrane |
Application - ellipse_099_nucleus1_1
Species | Initial Condition | Diffusion Constant | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
EGF_extra | 1.0 [uM] | 1.0
[um2/s] MAPK_active_N_nucleus |
0.0
[uM]
|
7.0
[um2/s] | Raf_active_cyto |
0.0
[uM]
|
7.0
[um2/s] | ATP |
5000.0
[uM]
|
10.0
[um2/s] | GAP |
0.1
[uM]
|
10.0
[um2/s] | MEK_cyto |
0.18
[uM]
|
6.0
[um2/s] | MAPK_active_cyto |
0.0
[uM]
|
7.0
[um2/s] | Ras_GAP_cyto |
0.002
[uM]
|
4.14
[um2/s] | MEK_active_cyto |
0.0
[uM]
|
6.0
[um2/s] | MAPK_cyto |
0.36
[uM]
|
7.0
[um2/s] | Sos_cyto |
1.0
[uM]
|
10.0
[um2/s] | SHC_p_cyto |
0.0
[uM]
|
6.4
[um2/s] | SHC_cyto |
1.0
[uM]
|
6.4
[um2/s] | Raf_cyto |
0.2
[uM]
|
7.0
[um2/s] | Grb2_cyto |
1.0
[uM]
|
8.5
[um2/s] | PP2A_cyto |
0.0
[uM]
|
0.0
[um2/s] | PP2A_inactive |
0.05
[uM]
|
0.0
[um2/s] | EGFR_active |
0.0
[uM]
|
0.0
[um2/s] | EGFR_GAP |
0.0
[uM]
|
0.08
[um2/s] | EGFR_cyto_mem |
400.0
[uM]
|
0.04
[um2/s] | EGFR_dimer |
0.0
[uM]
|
0.08
[um2/s] | Ras_GDP_cyto_mem |
500.0
[uM]
|
0.16
[um2/s] | Ras_GTP_cyto_mem |
0.0
[uM]
|
0.16
[um2/s] | EGFR_GAP_GRb2_Sos |
0.0
[uM]
|
0.0
[um2/s] | EGFR_Sos_Grb2_Shc_cyto_mem |
0.0
[uM]
|
0.08
[um2/s] | EGFR_GAP_Grb2 |
0.0
[uM]
|
0.0
[um2/s]
|
|
Name | Reaction Mapping |
---|---|
SHC dephosphorylation | included |
MEk activation | included |
nuclear transport | included |
receptor ligand binding | included |
Ras activation by Sos | included |
MAPK inactivation | included |
MAPK activation | included |
r0 | included |
Raf inactivation | included |
Ras GAP | included |
Raf activation | included |
MEK inactivation | included |
Sos binding | included |
Shc phosphorylation | included |
GAP binding | included |
Shc binding EGFR | included |
dimerization | included |
GRb2 binding | included |
Name | End Time | Output Options |
---|---|---|
Simulation5 | 15000.0 [s] |
OutputTimeStep 10.0 |
Dimension | Type | Subdomain | Adjacent Subvolumes | Size | Mapped Compartment |
---|---|---|---|---|---|
Volume | Analytical | subdomain0 | 37.682249999999996 [um2] | nucleus | |
Volume | Analytical | Cell | 37.29449999999999 [um2] | cyto | |
Volume | Analytical | ECM | 42.52324999999999 [um2] | extra | |
Surface | Cell_ECM_membrane | Cell | ECM | 93.46482136095845 [um] | cyto_mem | |
Surface | Cell_subdomain0_membrane | Cell | subdomain0 | 65.35262936922854 [um] | nuclear Membrane |
Application - ellipse_099_nucleus3_1
Species | Initial Condition | Diffusion Constant | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
EGF_extra | 1.0 [uM] | 1.0
[um2/s] MAPK_active_N_nucleus |
0.0
[uM]
|
7.0
[um2/s] | Raf_active_cyto |
0.0
[uM]
|
7.0
[um2/s] | ATP |
5000.0
[uM]
|
10.0
[um2/s] | GAP |
0.1
[uM]
|
10.0
[um2/s] | MEK_cyto |
0.18
[uM]
|
6.0
[um2/s] | MAPK_active_cyto |
0.0
[uM]
|
7.0
[um2/s] | Ras_GAP_cyto |
0.002
[uM]
|
4.14
[um2/s] | MEK_active_cyto |
0.0
[uM]
|
6.0
[um2/s] | MAPK_cyto |
0.36
[uM]
|
7.0
[um2/s] | Sos_cyto |
1.0
[uM]
|
10.0
[um2/s] | SHC_p_cyto |
0.0
[uM]
|
6.4
[um2/s] | SHC_cyto |
1.0
[uM]
|
6.4
[um2/s] | Raf_cyto |
0.2
[uM]
|
7.0
[um2/s] | Grb2_cyto |
1.0
[uM]
|
8.5
[um2/s] | PP2A_cyto |
0.0
[uM]
|
0.0
[um2/s] | PP2A_inactive |
0.05
[uM]
|
0.0
[um2/s] | EGFR_active |
0.0
[uM]
|
0.0
[um2/s] | EGFR_GAP |
0.0
[uM]
|
0.08
[um2/s] | EGFR_cyto_mem |
400.0
[uM]
|
0.04
[um2/s] | EGFR_dimer |
0.0
[uM]
|
0.08
[um2/s] | Ras_GDP_cyto_mem |
500.0
[uM]
|
0.16
[um2/s] | Ras_GTP_cyto_mem |
0.0
[uM]
|
0.16
[um2/s] | EGFR_GAP_GRb2_Sos |
0.0
[uM]
|
0.0
[um2/s] | EGFR_Sos_Grb2_Shc_cyto_mem |
0.0
[uM]
|
0.08
[um2/s] | EGFR_GAP_Grb2 |
0.0
[uM]
|
0.0
[um2/s]
|
|
Name | Reaction Mapping |
---|---|
SHC dephosphorylation | included |
MEk activation | included |
nuclear transport | included |
receptor ligand binding | included |
Ras activation by Sos | included |
MAPK inactivation | included |
MAPK activation | included |
r0 | included |
Raf inactivation | included |
Ras GAP | included |
Raf activation | included |
MEK inactivation | included |
Sos binding | included |
Shc phosphorylation | included |
GAP binding | included |
Shc binding EGFR | included |
dimerization | included |
GRb2 binding | included |
Name | End Time | Output Options |
---|---|---|
Simulation3 | 15000.0 [s] |
OutputTimeStep 10.0 |
Dimension | Type | Subdomain | Adjacent Subvolumes | Size | Mapped Compartment |
---|---|---|---|---|---|
Volume | Analytical | subdomain0 | 18.858749999999997 [um2] | nucleus | |
Volume | Analytical | Cell | 56.117999999999995 [um2] | cyto | |
Volume | Analytical | ECM | 42.52324999999999 [um2] | extra | |
Surface | Cell_ECM_membrane | Cell | ECM | 93.46482136095845 [um] | cyto_mem | |
Surface | Cell_subdomain0_membrane | Cell | subdomain0 | 46.33232970167217 [um] | nuclear Membrane |
Application - ellipse_099_nucleus5_1
Species | Initial Condition | Diffusion Constant | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
EGF_extra | 1.0 [uM] | 1.0
[um2/s] MAPK_active_N_nucleus |
0.0
[uM]
|
7.0
[um2/s] | Raf_active_cyto |
0.0
[uM]
|
7.0
[um2/s] | ATP |
5000.0
[uM]
|
10.0
[um2/s] | GAP |
0.1
[uM]
|
10.0
[um2/s] | MEK_cyto |
0.18
[uM]
|
6.0
[um2/s] | MAPK_active_cyto |
0.0
[uM]
|
7.0
[um2/s] | Ras_GAP_cyto |
0.002
[uM]
|
4.14
[um2/s] | MEK_active_cyto |
0.0
[uM]
|
6.0
[um2/s] | MAPK_cyto |
0.36
[uM]
|
7.0
[um2/s] | Sos_cyto |
1.0
[uM]
|
10.0
[um2/s] | SHC_p_cyto |
0.0
[uM]
|
6.4
[um2/s] | SHC_cyto |
1.0
[uM]
|
6.4
[um2/s] | Raf_cyto |
0.2
[uM]
|
7.0
[um2/s] | Grb2_cyto |
1.0
[uM]
|
8.5
[um2/s] | PP2A_cyto |
0.0
[uM]
|
0.0
[um2/s] | PP2A_inactive |
0.05
[uM]
|
0.0
[um2/s] | EGFR_active |
0.0
[uM]
|
0.0
[um2/s] | EGFR_GAP |
0.0
[uM]
|
0.08
[um2/s] | EGFR_cyto_mem |
400.0
[uM]
|
0.04
[um2/s] | EGFR_dimer |
0.0
[uM]
|
0.08
[um2/s] | Ras_GDP_cyto_mem |
500.0
[uM]
|
0.16
[um2/s] | Ras_GTP_cyto_mem |
0.0
[uM]
|
0.16
[um2/s] | EGFR_GAP_GRb2_Sos |
0.0
[uM]
|
0.0
[um2/s] | EGFR_Sos_Grb2_Shc_cyto_mem |
0.0
[uM]
|
0.08
[um2/s] | EGFR_GAP_Grb2 |
0.0
[uM]
|
0.0
[um2/s]
|
|
Name | Reaction Mapping |
---|---|
SHC dephosphorylation | included |
MEk activation | included |
nuclear transport | included |
receptor ligand binding | included |
Ras activation by Sos | included |
MAPK inactivation | included |
MAPK activation | included |
r0 | included |
Raf inactivation | included |
Ras GAP | included |
Raf activation | included |
MEK inactivation | included |
Sos binding | included |
Shc phosphorylation | included |
GAP binding | included |
Shc binding EGFR | included |
dimerization | included |
GRb2 binding | included |
Name | End Time | Output Options |
---|---|---|
Simulation4 | 15000.0 [s] |
OutputTimeStep 10.0 |
Copy of Simulation4 | 60.0 [s] |
OutputTimeStep 10.0 |
Dimension | Type | Subdomain | Adjacent Subvolumes | Size | Mapped Compartment |
---|---|---|---|---|---|
Volume | Analytical | subdomain0 | 12.560749999999999 [um2] | nucleus | |
Volume | Analytical | Cell | 62.41599999999999 [um2] | cyto | |
Volume | Analytical | ECM | 42.52324999999999 [um2] | extra | |
Surface | Cell_ECM_membrane | Cell | ECM | 93.46482136095845 [um] | cyto_mem | |
Surface | Cell_subdomain0_membrane | Cell | subdomain0 | 38.29432490973859 [um] | nuclear Membrane |
Application - spatially varying diffusion and receptor number
Species | Initial Condition | Diffusion Constant | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
EGF_extra | 1.0 [uM] | 1.0
[um2/s] MAPK_active_N_nucleus |
0.0
[uM]
|
7.0
[um2/s] | Raf_active_cyto |
0.0
[uM]
|
7.0
[um2/s] | ATP |
5000.0
[uM]
|
10.0
[um2/s] | GAP |
0.1
[uM]
|
10.0
[um2/s] | MEK_cyto |
0.18
[uM]
|
6.0
[um2/s] | MAPK_active_cyto |
0.0
[uM]
|
7.0
[um2/s] | Ras_GAP_cyto |
0.002
[uM]
|
4.14
[um2/s] | MEK_active_cyto |
0.0
[uM]
|
6.0
[um2/s] | MAPK_cyto |
0.36
[uM]
|
7.0
[um2/s] | Sos_cyto |
1.0
[uM]
|
3.7
[um2/s] | SHC_p_cyto |
0.0
[uM]
|
6.4
[um2/s] | SHC_cyto |
1.0
[uM]
|
6.4
[um2/s] | Raf_cyto |
0.2
[uM]
|
7.0
[um2/s] | Grb2_cyto |
1.0
[uM]
|
8.5
[um2/s] | PP2A_cyto |
0.0
[uM]
|
0.0
[um2/s] | PP2A_inactive |
0.05
[uM]
|
0.0
[um2/s] | EGFR_active |
0.0
[uM]
|
0.0
[um2/s] | EGFR_GAP |
0.0
[uM]
|
0.08
[um2/s] | EGFR_cyto_mem |
(213.0 * (1.0 + (0.018 * abs(x))))
[uM]
|
(0.112 * (1.0 + (0.018 * abs(x))))
[um2/s] | EGFR_dimer |
0.0
[uM]
|
0.08
[um2/s] | Ras_GDP_cyto_mem |
500.0
[uM]
|
0.16
[um2/s] | Ras_GTP_cyto_mem |
0.0
[uM]
|
0.16
[um2/s] | EGFR_GAP_GRb2_Sos |
0.0
[uM]
|
0.0
[um2/s] | EGFR_Sos_Grb2_Shc_cyto_mem |
0.0
[uM]
|
(0.08 * (1.0 + (0.03 * abs(x))))
[um2/s] | EGFR_GAP_Grb2 |
0.0
[uM]
|
0.0
[um2/s]
|
|
Name | Reaction Mapping |
---|---|
SHC dephosphorylation | included |
MEk activation | included |
nuclear transport | included |
receptor ligand binding | included |
Ras activation by Sos | included |
MAPK inactivation | included |
MAPK activation | included |
r0 | included |
Raf inactivation | included |
Ras GAP | included |
Raf activation | included |
MEK inactivation | included |
Sos binding | included |
Shc phosphorylation | included |
GAP binding | included |
Shc binding EGFR | included |
dimerization | included |
GRb2 binding | included |
Name | End Time | Output Options |
---|---|---|
Simulation6 | 60.0 [s] |
OutputTimeStep 10.0 |
Simulation7 | 3600.0 [s] |
OutputTimeStep 10.0 |
Simulation8 | 7200.0 [s] |
OutputTimeStep 10.0 |
Simulation9 | 3600.0 [s] |
OutputTimeStep 10.0 |
Simulation10 | 3600.0 [s] |
OutputTimeStep 10.0 |
Copy of Simulation6 | 480.0 [s] |
OutputTimeStep 10.0 |
Dimension | Type | Subdomain | Adjacent Subvolumes | Size | Mapped Compartment |
---|---|---|---|---|---|
Volume | Analytical | nucleus | 12.308944744072456 [um2] | nucleus | |
Volume | Analytical | cell | 156.20637020453853 [um2] | cyto | |
Volume | Analytical | ECM | 191.48468505138905 [um2] | extra | |
Surface | ECM_cell_membrane | ECM | cell | 108.81799234890245 [um] | cyto_mem | |
Surface | cell_nucleus_membrane | cell | nucleus | 36.43730612082122 [um] | nuclear Membrane |
Application - circle fine mesh
Species | Initial Condition | Diffusion Constant | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
EGF_extra | 1.0 [uM] | 1.0
[um2/s] MAPK_active_N_nucleus |
0.0
[uM]
|
7.0
[um2/s] | Raf_active_cyto |
0.0
[uM]
|
7.0
[um2/s] | ATP |
5000.0
[uM]
|
10.0
[um2/s] | GAP |
0.1
[uM]
|
10.0
[um2/s] | MEK_cyto |
0.18
[uM]
|
6.0
[um2/s] | MAPK_active_cyto |
0.0
[uM]
|
7.0
[um2/s] | Ras_GAP_cyto |
0.002
[uM]
|
4.14
[um2/s] | MEK_active_cyto |
0.0
[uM]
|
6.0
[um2/s] | MAPK_cyto |
0.36
[uM]
|
7.0
[um2/s] | Sos_cyto |
1.0
[uM]
|
10.0
[um2/s] | SHC_p_cyto |
0.0
[uM]
|
6.4
[um2/s] | SHC_cyto |
1.0
[uM]
|
6.4
[um2/s] | Raf_cyto |
0.2
[uM]
|
7.0
[um2/s] | Grb2_cyto |
1.0
[uM]
|
8.5
[um2/s] | PP2A_cyto |
0.0
[uM]
|
0.0
[um2/s] | PP2A_inactive |
0.05
[uM]
|
0.0
[um2/s] | EGFR_active |
0.0
[uM]
|
0.0
[um2/s] | EGFR_GAP |
0.0
[uM]
|
0.08
[um2/s] | EGFR_cyto_mem |
400.0
[uM]
|
0.04
[um2/s] | EGFR_dimer |
0.0
[uM]
|
0.08
[um2/s] | Ras_GDP_cyto_mem |
500.0
[uM]
|
0.16
[um2/s] | Ras_GTP_cyto_mem |
0.0
[uM]
|
0.16
[um2/s] | EGFR_GAP_GRb2_Sos |
0.0
[uM]
|
0.0
[um2/s] | EGFR_Sos_Grb2_Shc_cyto_mem |
0.0
[uM]
|
0.08
[um2/s] | EGFR_GAP_Grb2 |
0.0
[uM]
|
0.0
[um2/s]
|
|
Name | Reaction Mapping |
---|---|
SHC dephosphorylation | included |
MEk activation | included |
nuclear transport | included |
receptor ligand binding | included |
Ras activation by Sos | included |
MAPK inactivation | included |
MAPK activation | included |
r0 | included |
Raf inactivation | included |
Ras GAP | included |
Raf activation | included |
MEK inactivation | included |
Sos binding | included |
Shc phosphorylation | included |
GAP binding | included |
Shc binding EGFR | included |
dimerization | included |
GRb2 binding | included |
Name | End Time | Output Options |
---|---|---|
Simulation11 | 60.0 [s] |
OutputTimeStep 10.0 |
Simulation14 | 7200.0 [s] |
OutputTimeStep 10.0 |
Dimension | Type | Subdomain | Adjacent Subvolumes | Size | Mapped Compartment |
---|---|---|---|---|---|
Volume | Analytical | nucleus | 12.313600000000001 [um2] | nucleus | |
Volume | Analytical | cyto | 156.97920000000002 [um2] | cyto | |
Volume | Analytical | ecm | 86.7072 [um2] | extra | |
Surface | cyto_ecm_membrane | cyto | ecm | 46.21278101811295 [um] | cyto_mem | |
Surface | cyto_nucleus_membrane | cyto | nucleus | 12.415157207294083 [um] | nuclear Membrane |
Application - ellipse fine mesh
Species | Initial Condition | Diffusion Constant | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
EGF_extra | 1.0 [uM] | 1.0
[um2/s] MAPK_active_N_nucleus |
0.0
[uM]
|
7.0
[um2/s] | Raf_active_cyto |
0.0
[uM]
|
7.0
[um2/s] | ATP |
5000.0
[uM]
|
10.0
[um2/s] | GAP |
0.1
[uM]
|
10.0
[um2/s] | MEK_cyto |
0.18
[uM]
|
6.0
[um2/s] | MAPK_active_cyto |
0.0
[uM]
|
7.0
[um2/s] | Ras_GAP_cyto |
0.002
[uM]
|
4.14
[um2/s] | MEK_active_cyto |
0.0
[uM]
|
6.0
[um2/s] | MAPK_cyto |
0.36
[uM]
|
7.0
[um2/s] | Sos_cyto |
1.0
[uM]
|
10.0
[um2/s] | SHC_p_cyto |
0.0
[uM]
|
6.4
[um2/s] | SHC_cyto |
1.0
[uM]
|
6.4
[um2/s] | Raf_cyto |
0.2
[uM]
|
7.0
[um2/s] | Grb2_cyto |
1.0
[uM]
|
8.5
[um2/s] | PP2A_cyto |
0.0
[uM]
|
0.0
[um2/s] | PP2A_inactive |
0.05
[uM]
|
0.0
[um2/s] | EGFR_active |
0.0
[uM]
|
0.0
[um2/s] | EGFR_GAP |
0.0
[uM]
|
0.08
[um2/s] | EGFR_cyto_mem |
400.0
[uM]
|
0.04
[um2/s] | EGFR_dimer |
0.0
[uM]
|
0.08
[um2/s] | Ras_GDP_cyto_mem |
500.0
[uM]
|
0.16
[um2/s] | Ras_GTP_cyto_mem |
0.0
[uM]
|
0.16
[um2/s] | EGFR_GAP_GRb2_Sos |
0.0
[uM]
|
0.0
[um2/s] | EGFR_Sos_Grb2_Shc_cyto_mem |
0.0
[uM]
|
0.08
[um2/s] | EGFR_GAP_Grb2 |
0.0
[uM]
|
0.0
[um2/s]
|
|
Name | Reaction Mapping |
---|---|
SHC dephosphorylation | included |
MEk activation | included |
nuclear transport | included |
receptor ligand binding | included |
Ras activation by Sos | included |
MAPK inactivation | included |
MAPK activation | included |
r0 | included |
Raf inactivation | included |
Ras GAP | included |
Raf activation | included |
MEK inactivation | included |
Sos binding | included |
Shc phosphorylation | included |
GAP binding | included |
Shc binding EGFR | included |
dimerization | included |
GRb2 binding | included |
Name | End Time | Output Options |
---|---|---|
Simulation15 | 60.0 [s] |
OutputTimeStep 10.0 |
Dimension | Type | Subdomain | Adjacent Subvolumes | Size | Mapped Compartment |
---|---|---|---|---|---|
Volume | Analytical | subdomain0 | 12.40975935828877 [um2] | nucleus | |
Volume | Analytical | Cell | 62.52005347593583 [um2] | cyto | |
Volume | Analytical | ECM | 42.5701871657754 [um2] | extra | |
Surface | Cell_ECM_membrane | Cell | ECM | 93.03794179617861 [um] | cyto_mem | |
Surface | Cell_subdomain0_membrane | Cell | subdomain0 | 37.60040211638436 [um] | nuclear Membrane |
Global Parameters
Name | Expression |
---|---|
n | 1200.0[molecules.um-2.uM-1] |
|
|