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Name - Activation_ERK

BioModel ID - 211729099

Reaction Diagram

reactionDiagram

Physiology

Universal ID's	Text Annotations

Reactions See in Dashboard
Reaction	Name Structure	Kinetics	Depiction
ErkErk_act	Erk_Activation cell	GeneralKinetics	ErkErk_act
		reaction rate (J): (Kcat_act * Mek_act * Erk / (km_act + Erk))[mmol.ml-1.min-1]
Erk_actErk	Erk_Deactivation cell	GeneralKinetics	Erk_actErk
		reaction rate (J): (Kcat_inact * PP2A_act * Erk_act / (km_inact + Erk_act))[mmol.ml-1.min-1]

Structures See in Dashboard
Name	Type Electrical (Membrane Polarity)
cell	Compartment (+) (-)

Species See in Dashboard
Name	Structure	BioNetGen Definition
Mek_act	cell	MEK(Active~yes!-,).

Erk_act	cell	ERK(Phosphorylated~yes!-,).

Erk	cell	ERK(Phosphorylated~no!-,).

PP2A_act	cell	PP2A(Active~yes!-,).

Molecules See in Dashboard
Name	Text Annotations	BioNetGen Definition
MEK	Text Annotations	MEK(Active~yes~no,)

ERK	Text Annotations	ERK(Phosphorylated~yes~no,)

PP2A	Text Annotations	PP2A(Active~yes~no,)

Observables See in Dashboard
Name	Type Count	BioNetGen Definition

Applications

Applications See in Dashboard
Name	Math Type	Annotation
Deterministic	Deterministic (ODE) Compartmental	cloned from 'Deterministic' owned by user PraneetDangol cloned from 'Deterministic' owned by user ModelBrick cloned from 'Deterministic' owned by user savi06 cloned from 'Deterministic' owned by user mblinov cloned from 'Deterministic' owned by user cab15130

Application - Deterministic

Specifications(Species) - Deterministic See in Dashboard
Species	Initial Condition	Diffusion Constant
Mek_act	0.0 [mmol]	0.0 [m2/min]
Erk_act	0.0 [mmol]	0.0 [m2/min]
Erk	600000.0 [mmol]	0.0 [m2/min]
PP2A_act	120000.0 [mmol]	0.0 [m2/min]

Specifications(Reaction) - Deterministic See in Dashboard
Name	Reaction Mapping
Erk_Activation	included
Erk_Deactivation	included

Simulations - Deterministic See in Dashboard
Name	End Time	Output Options

Geometry Compartmental968719063 See in Dashboard
(Origin: 0.0, 0.0, 0.0; Extent: 10.0, 10.0, 10.0[m])
Dimension	Type	Subdomain	Adjacent Subvolumes	Size	Mapped Compartment
	Compartmental	Compartment			cell

Global Parameters

Global Parameters See in Dashboard
Name	Expression
km_inact	3496490.0[mmol.ml-1]

Kcat_inact	8.8912[min-1]

km_act	1007340.0[mmol.ml-1]

Kcat_act	9.85367[min-1]