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Name - Activation_PI3K

BioModel ID - 211728761

Reaction Diagram

reactionDiagram

Physiology

Universal ID's	Text Annotations

Reactions See in Dashboard
Reaction	Name Structure	Kinetics	Depiction
PI3KPI3K_act	PI3K_Activation_EGFR cell	GeneralKinetics	PI3KPI3K_act
		reaction rate (J): (Kcat_act * LR * PI3K / (km_act + PI3K))[mmol.ml-1.min-1]
PI3KPI3K_act	PI3K_Activation_Ras cell	GeneralKinetics	PI3KPI3K_act
		reaction rate (J): (Kcat_PI3Kact * Ras_act * PI3K / (km_PI3K_act + PI3K))[mmol.ml-1.min-1]
PI3K_actPI3K	PI3K_Deactivation cell	GeneralKinetics	PI3K_actPI3K
		reaction rate (J): (k1_act * PI3K_act)[mmol.ml-1.min-1]

Structures See in Dashboard
Name	Type Electrical (Membrane Polarity)
cell	Compartment (+) (-)

Species See in Dashboard
Name	Structure	BioNetGen Definition
LR	cell	EGF(EGF!1,).EGFR(ecd!1,Y~P!-,).

Ras_act	cell	Ras(Active~yes!-,).

PI3K_act	cell	PI3K(Active~yes!-,).

PI3K	cell	PI3K(Active~no!-,).

Molecules See in Dashboard
Name	Text Annotations	BioNetGen Definition
EGFR	Text Annotations	EGFR(ecd,Y~P~U,)

EGF	Text Annotations	EGF(EGF,)

Ras	Text Annotations	Ras(Active~yes~no,)

PI3K	Text Annotations	PI3K(Active~yes~no,)

Observables See in Dashboard
Name	Type Count	BioNetGen Definition

Applications

Applications See in Dashboard
Name	Math Type	Annotation
Deterministic	Deterministic (ODE) Compartmental	cloned from 'Deterministic' owned by user PraneetDangol cloned from 'Deterministic' owned by user ModelBrick cloned from 'Deterministic' owned by user savi06 cloned from 'Deterministic' owned by user mblinov cloned from 'Deterministic' owned by user cab15130

Application - Deterministic

Specifications(Species) - Deterministic See in Dashboard
Species	Initial Condition	Diffusion Constant
LR	0.0 [mmol]	0.0 [m2/min]
Ras_act	0.0 [mmol]	0.0 [m2/min]
PI3K_act	0.0 [mmol]	0.0 [m2/min]
PI3K	120000.0 [mmol]	0.0 [m2/min]

Specifications(Reaction) - Deterministic See in Dashboard
Name	Reaction Mapping
PI3K_Activation_EGFR	included
PI3K_Activation_Ras	included
PI3K_Deactivation	included

Simulations - Deterministic See in Dashboard
Name	End Time	Output Options

Geometry Compartmental1573685769 See in Dashboard
(Origin: 0.0, 0.0, 0.0; Extent: 10.0, 10.0, 10.0[m])
Dimension	Type	Subdomain	Adjacent Subvolumes	Size	Mapped Compartment
	Compartmental	Compartment			cell

Global Parameters

Global Parameters See in Dashboard
Name	Expression
Kcat_act	10.6737[min-1]

km_act	184912.0[mmol.ml-1]

km_PI3K_act	272056.0[mmol.ml-1]

Kcat_PI3Kact	0.0771067[min-1]

k1_act	0.005[min-1]