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Name - Activation_Raf1

BioModel ID - 211119506

Reaction Diagram

reactionDiagram

Physiology

Universal ID's	Text Annotations

Reactions See in Dashboard
Reaction	Name Structure	Kinetics	Depiction
Raf1_inactRaf1_act	Raf1_Activation cell	GeneralKinetics	Raf1_inactRaf1_act
		reaction rate (J): (Kcat_act * Ras_act * Raf1_inact / (km_act + Raf1_inact))[mmol.ml-1.min-1]
Raf1_actRaf1_inact	Raf1_Deactivation cell	GeneralKinetics	Raf1_actRaf1_inact
		reaction rate (J): (Kcat_inact_PPt * Raf1_PPtase * Raf1_act / (km_inact_PPt + Raf1_act))[mmol.ml-1.min-1]
Raf1_actRaf1_inact	Raf1_Deactivation_Akt cell	GeneralKinetics	Raf1_actRaf1_inact
		reaction rate (J): (Kcat_inact_Akt * Akt_act * Raf1_act / (km_inact_Akt + Raf1_act))[mmol.ml-1.min-1]

Structures See in Dashboard
Name	Type Electrical (Membrane Polarity)
cell	Compartment (+) (-)

Species See in Dashboard
Name	Structure	BioNetGen Definition
Ras_act	cell	Ras(status~active!-,).

Raf1_act	cell	Raf(status~active!-,).

Raf1_inact	cell	Raf(status~inactive!-,).

Akt_act	cell	Akt(status~active!-,).

Raf1_PPtase	cell	Raf(status~inactive!-,).Phosphotase().

Molecules See in Dashboard
Name	Text Annotations	BioNetGen Definition
Ras	Text Annotations	Ras(status~active~inactive,)

Raf	Text Annotations	Raf(status~active~inactive,)

Akt	Text Annotations	Akt(status~active~inactive,)

Phosphotase	Text Annotations	Phosphotase()

Observables See in Dashboard
Name	Type Count	BioNetGen Definition
Raf_total	Molecules Multimolecular	Raf(status!-,).

Applications

Applications See in Dashboard
Name	Math Type	Annotation
Deterministic	Deterministic (ODE) Compartmental	cloned from 'Deterministic' owned by user savi06 cloned from 'Deterministic' owned by user mblinov cloned from 'Deterministic' owned by user cab15130

Application - Deterministic

Specifications(Species) - Deterministic See in Dashboard
Species	Initial Condition	Diffusion Constant
Ras_act	0.0 [mmol]	0.0 [m2/min]
Raf1_act	0.0 [mmol]	0.0 [m2/min]
Raf1_inact	120000.0 [mmol]	0.0 [m2/min]
Akt_act	0.0 [mmol]	0.0 [m2/min]
Raf1_PPtase	120000.0 [mmol]	0.0 [m2/min]

Specifications(Reaction) - Deterministic See in Dashboard
Name	Reaction Mapping
Raf1_Activation	included
Raf1_Deactivation	included
Raf1_Deactivation_Akt	included

Simulations - Deterministic See in Dashboard
Name	End Time	Output Options

Geometry Compartmental1716227696 See in Dashboard
(Origin: 0.0, 0.0, 0.0; Extent: 10.0, 10.0, 10.0[m])
Dimension	Type	Subdomain	Adjacent Subvolumes	Size	Mapped Compartment
	Compartmental	Compartment			cell

Global Parameters

Global Parameters See in Dashboard
Name	Expression
km_act	62464.6[mmol.ml-1]

Kcat_act	0.884096[min-1]

Kcat_inact_PPt	0.126329[min-1]

km_inact_PPt	1061.71[mmol.ml-1]

Kcat_inact_Akt	15.1212[min-1]

km_inact_Akt	119355.0[mmol.ml-1]