ModelBricks - Model Print Page

Universal ID's	Text Annotations

Reactions See in Dashboard
Reaction	Name Structure	Kinetics	Depiction
Raf1+GTP_RasRas_Raf1	Ras_Raf1_bind pm	MassAction	Raf1+GTP_RasRas_Raf1
		reaction rate (J): (((Kf * Raf1) * GTP_Ras) - (Kr * Ras_Raf1))[molecules.um-2.min-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kR1f[min-1.uM-1] reverse rate constant (Kr): kR1r[min-1]
Ras_BRaf+Ras_Raf1Ras_BRaf_Raf1_tetramer	BRaf_Raf1_bind pm	MassAction	Ras_BRaf+Ras_Raf1Ras_BRaf_Raf1_tetramer
		reaction rate (J): (((Kf * Ras_BRaf) * Ras_Raf1) - (Kr * Ras_BRaf_Raf1_tetramer))[molecules.um-2.min-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kdR1f[um2.min-1.molecules-1] reverse rate constant (Kr): kdR1r[min-1]
Ras_BRaf_Raf1_tetramerRas_BRaf_pRaf1_tetramer	BRaf_Raf1_phosph pm	MassAction	Ras_BRaf_Raf1_tetramerRas_BRaf_pRaf1_tetramer
		reaction rate (J): ((Kf * Ras_BRaf_Raf1_tetramer) - (Kr * Ras_BRaf_pRaf1_tetramer))[molecules.um-2.min-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kpR1[min-1] reverse rate constant (Kr): 0.0[min-1]
Ras_pRaf1pRaf1+GTP_Ras	Ras_pRaf1_unbind pm	MassAction	Ras_pRaf1pRaf1+GTP_Ras
		reaction rate (J): ((Kf * Ras_pRaf1) - ((Kr * pRaf1) * GTP_Ras))[molecules.um-2.min-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kR1r[min-1] reverse rate constant (Kr): kR1f[min-1.uM-1]
BRaf+GTP_RasRas_BRaf	Ras_BRaf_bind pm	MassAction	BRaf+GTP_RasRas_BRaf
		reaction rate (J): (((Kf * BRaf) * GTP_Ras) - (Kr * Ras_BRaf))[molecules.um-2.min-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kBf[min-1.uM-1] reverse rate constant (Kr): kBr[min-1]
Ras_pRaf1+Ras_Raf1Ras_pRaf1_Raf1_tetramer	pRaf1_Raf1_bind pm	MassAction	Ras_pRaf1+Ras_Raf1Ras_pRaf1_Raf1_tetramer
		reaction rate (J): (((Kf * Ras_pRaf1) * Ras_Raf1) - (Kr * Ras_pRaf1_Raf1_tetramer))[molecules.um-2.min-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kdR1f[um2.min-1.molecules-1] reverse rate constant (Kr): kdR1r[min-1]
Ras_pRaf1_Raf1_tetramerRas_pRaf1_tetramer	pRaf1_Raf1_phosph pm	MassAction	Ras_pRaf1_Raf1_tetramerRas_pRaf1_tetramer
		reaction rate (J): ((Kf * Ras_pRaf1_Raf1_tetramer) - (Kr * Ras_pRaf1_tetramer))[molecules.um-2.min-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kpR1[min-1] reverse rate constant (Kr): 0.0[min-1]
sorafenib+Raf1iRaf1	sorafenib_Raf1_bind_cyt cytoplasm	MassAction	sorafenib+Raf1iRaf1
		reaction rate (J): (((Kf * sorafenib) * Raf1) - (Kr * iRaf1))[uM.min-1] forward rate constant (Kf): kSon[min-1.uM-1] reverse rate constant (Kr): kSoff[min-1]
iRaf1+GTP_RasRas_iRaf1	Ras_iRaf1_bind pm	MassAction	iRaf1+GTP_RasRas_iRaf1
		reaction rate (J): (((Kf * iRaf1) * GTP_Ras) - (Kr * Ras_iRaf1))[molecules.um-2.min-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kiR1f[min-1.uM-1] reverse rate constant (Kr): kiR1r[min-1]
Ras_iRaf1Ras_iRaf1_tetramer	iRaf1_iRaf1_bind pm	MassAction	Ras_iRaf1Ras_iRaf1_tetramer
		reaction rate (J): ((Kf * pow(Ras_iRaf1,2.0)) - (Kr * Ras_iRaf1_tetramer))[molecules.um-2.min-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kdR1f[um2.min-1.molecules-1] reverse rate constant (Kr): kdR1r[min-1]
Ras_BRaf+Ras_iRaf1Ras_Braf_iRaf1_tetramer	BRaf_iRaf1_bind pm	MassAction	Ras_BRaf+Ras_iRaf1Ras_Braf_iRaf1_tetramer
		reaction rate (J): (((Kf * Ras_BRaf) * Ras_iRaf1) - (Kr * Ras_Braf_iRaf1_tetramer))[molecules.um-2.min-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kdR1f[um2.min-1.molecules-1] reverse rate constant (Kr): kdR1r[min-1]
pRaf1Raf1	pRaf1_dephosph cytoplasm	MassAction	pRaf1Raf1
		reaction rate (J): ((Kf * pRaf1) - (Kr * Raf1))[uM.min-1] forward rate constant (Kf): kdpR1[min-1] reverse rate constant (Kr): 0.0[min-1]
Ras_pRaf1_tetramerRas_pRaf1	pRaf1_pRaf1_unbind pm	MassAction	Ras_pRaf1_tetramerRas_pRaf1
		reaction rate (J): ((Kf * Ras_pRaf1_tetramer) - (Kr * pow(Ras_pRaf1,2.0)))[molecules.um-2.min-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kdR1r[min-1] reverse rate constant (Kr): kdR1f[um2.min-1.molecules-1]
Ras_BRaf_pRaf1_tetramerRas_BRaf+Ras_pRaf1	BRaf_pRaf1_unbind pm	MassAction	Ras_BRaf_pRaf1_tetramerRas_BRaf+Ras_pRaf1
		reaction rate (J): ((Kf * Ras_BRaf_pRaf1_tetramer) - ((Kr * Ras_BRaf) * Ras_pRaf1))[molecules.um-2.min-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kdR1r[min-1] reverse rate constant (Kr): kdR1f[um2.min-1.molecules-1]
sorafenib+BRafiBRaf	sorafenib_BRaf_bind_cyt cytoplasm	MassAction	sorafenib+BRafiBRaf
		reaction rate (J): (((Kf * sorafenib) * BRaf) - (Kr * iBRaf))[uM.min-1] forward rate constant (Kf): kSon[min-1.uM-1] reverse rate constant (Kr): kSoff[min-1]
MEKpMEK	MEK_p cytoplasm	MassAction	MEKpMEK
		reaction rate (J): ((Kf * MEK) - (Kr * pMEK))[uM.min-1] forward rate constant (Kf): (kMEKp * active_Raf)[min-1] reverse rate constant (Kr): 0.0[min-1]
pMEKMEK	MEK_dp cytoplasm	MassAction	pMEKMEK
		reaction rate (J): ((Kf * pMEK) - (Kr * MEK))[uM.min-1] forward rate constant (Kf): kMEKdp[min-1] reverse rate constant (Kr): 0.0[min-1]
ERKpERK	ERK_p cytoplasm	MassAction	ERKpERK
		reaction rate (J): ((Kf * ERK) - (Kr * pERK))[uM.min-1] forward rate constant (Kf): (kERKp * pMEK)[min-1] reverse rate constant (Kr): 0.0[min-1]
pERKERK	ERK_dp cytoplasm	MassAction	pERKERK
		reaction rate (J): ((Kf * pERK) - (Kr * ERK))[uM.min-1] forward rate constant (Kf): kERKdp[min-1] reverse rate constant (Kr): 0.0[min-1]
iBRafRas_iBRaf	Ras_iBRaf_b pm	MassAction	iBRafRas_iBRaf
		reaction rate (J): ((Kf * iBRaf) - (Kr * Ras_iBRaf))[molecules.um-2.min-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kiBf[molecules.um-2.min-1.uM-1] reverse rate constant (Kr): kiBr[min-1]
Ras_iBRafiBRaf_dimer	iBRaf_dim pm	MassAction	Ras_iBRafiBRaf_dimer
		reaction rate (J): ((Kf * Ras_iBRaf) - (Kr * iBRaf_dimer))[molecules.um-2.min-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kdR1f[min-1] reverse rate constant (Kr): kdR1r[min-1]
Ras_Raf1+Ras_iBRafRas_Raf1_iBRaf_tetramer	iBRaf_Raf1_bind pm	MassAction	Ras_Raf1+Ras_iBRafRas_Raf1_iBRaf_tetramer
		reaction rate (J): (((Kf * Ras_Raf1) * Ras_iBRaf) - (Kr * Ras_Raf1_iBRaf_tetramer))[molecules.um-2.min-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kdR1f[um2.min-1.molecules-1] reverse rate constant (Kr): kdR1r[min-1]
Ras_Raf1_iBRaf_tetramerRas_pRaf1_iBRaf_tetramer	Raf1_iBRaf_p pm	MassAction	Ras_Raf1_iBRaf_tetramerRas_pRaf1_iBRaf_tetramer
		reaction rate (J): ((Kf * Ras_Raf1_iBRaf_tetramer) - (Kr * Ras_pRaf1_iBRaf_tetramer))[molecules.um-2.min-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kpR1[min-1] reverse rate constant (Kr): 0.0[min-1]
Ras_pRaf1_iBRaf_tetramerRas_iBRaf+Ras_pRaf1	pRaf1_iBRaf_ub pm	MassAction	Ras_pRaf1_iBRaf_tetramerRas_iBRaf+Ras_pRaf1
		reaction rate (J): ((Kf * Ras_pRaf1_iBRaf_tetramer) - ((Kr * Ras_iBRaf) * Ras_pRaf1))[molecules.um-2.min-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kdR1r[min-1] reverse rate constant (Kr): kdR1f[um2.min-1.molecules-1]
Ras_BRafBRaf_dimer	BRaf_dim pm	MassAction	Ras_BRafBRaf_dimer
		reaction rate (J): ((Kf * Ras_BRaf) - (Kr * BRaf_dimer))[molecules.um-2.min-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kdR1f[min-1] reverse rate constant (Kr): kdR1r[min-1]
Ras_pRaf1Ras_Raf1	Ras_pRaf1_dp pm	MassAction	Ras_pRaf1Ras_Raf1
		reaction rate (J): ((Kf * Ras_pRaf1) - (Kr * Ras_Raf1))[molecules.um-2.min-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kdpR1[min-1] reverse rate constant (Kr): 0.0[min-1]
Ras_Raf1Ras_nfpRaf1	Ras_Raf1_nfp pm	MassAction	Ras_Raf1Ras_nfpRaf1
		reaction rate (J): ((Kf * Ras_Raf1) - (Kr * Ras_nfpRaf1))[molecules.um-2.min-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): (knfpBR1 * pERK)[min-1] reverse rate constant (Kr): 0.0[min-1]
Ras_nfpRaf1GTP_Ras+nfpRaf1	nfpRaf1_ub pm	MassAction	Ras_nfpRaf1GTP_Ras+nfpRaf1
		reaction rate (J): ((Kf * Ras_nfpRaf1) - ((Kr * GTP_Ras) * nfpRaf1))[molecules.um-2.min-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kfpR1r[min-1] reverse rate constant (Kr): 0.0[min-1.uM-1]
nfpRaf1Raf1	nfpRaf1_dp cytoplasm	MassAction	nfpRaf1Raf1
		reaction rate (J): ((Kf * nfpRaf1) - (Kr * Raf1))[uM.min-1] forward rate constant (Kf): kdpR1[min-1] reverse rate constant (Kr): 0.0[min-1]
Ras_BRafRas_nfpBRaf	BRaf_nfp pm	MassAction	Ras_BRafRas_nfpBRaf
		reaction rate (J): ((Kf * Ras_BRaf) - (Kr * Ras_nfpBRaf))[molecules.um-2.min-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): (knfpBR1 * pERK)[min-1] reverse rate constant (Kr): 0.0[min-1]
Ras_nfpBRafGTP_Ras+nfpBRaf	nfpBRaf_ub pm	MassAction	Ras_nfpBRafGTP_Ras+nfpBRaf
		reaction rate (J): ((Kf * Ras_nfpBRaf) - ((Kr * GTP_Ras) * nfpBRaf))[molecules.um-2.min-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kfpBr[min-1] reverse rate constant (Kr): 0.0[min-1.uM-1]
nfpBRafBRaf	nfpBRaf_dp cytoplasm	MassAction	nfpBRafBRaf
		reaction rate (J): ((Kf * nfpBRaf) - (Kr * BRaf))[uM.min-1] forward rate constant (Kf): kdpR1[min-1] reverse rate constant (Kr): 0.0[min-1]
Ras_iBRaf+Ras_BRafBRaf_iBRaf_dimer	BRaf_iBRaf_dim pm	MassAction	Ras_iBRaf+Ras_BRafBRaf_iBRaf_dimer
		reaction rate (J): (((Kf * Ras_iBRaf) * Ras_BRaf) - (Kr * BRaf_iBRaf_dimer))[molecules.um-2.min-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kdR1f[um2.min-1.molecules-1] reverse rate constant (Kr): kdR1r[min-1]
Ras_iRaf1Ras_nfpiRaf1	Ras_iRaf_nfp pm	MassAction	Ras_iRaf1Ras_nfpiRaf1
		reaction rate (J): ((Kf * Ras_iRaf1) - (Kr * Ras_nfpiRaf1))[molecules.um-2.min-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): (kpR1 * pERK)[min-1] reverse rate constant (Kr): 0.0[min-1]
Ras_nfpiRaf1nfpiRaf1+GTP_Ras	nfpiRaf1_ub pm	MassAction	Ras_nfpiRaf1nfpiRaf1+GTP_Ras
		reaction rate (J): ((Kf * Ras_nfpiRaf1) - ((Kr * nfpiRaf1) * GTP_Ras))[molecules.um-2.min-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kfpR1r[min-1] reverse rate constant (Kr): 0.0[min-1.uM-1]
nfpiRaf1iRaf1	nfpiRaf_dp cytoplasm	MassAction	nfpiRaf1iRaf1
		reaction rate (J): ((Kf * nfpiRaf1) - (Kr * iRaf1))[uM.min-1] forward rate constant (Kf): kdpR1[min-1] reverse rate constant (Kr): 0.0[min-1]
Ras_iBRafRas_nfpiBRaf	Ras_iBRaf_nfp pm	MassAction	Ras_iBRafRas_nfpiBRaf
		reaction rate (J): ((Kf * Ras_iBRaf) - (Kr * Ras_nfpiBRaf))[molecules.um-2.min-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): (knfpBR1 * pERK)[min-1] reverse rate constant (Kr): 0.0[min-1]
Ras_nfpiBRafnfpiBRaf+GTP_Ras	nfpiBRaf_ub pm	MassAction	Ras_nfpiBRafnfpiBRaf+GTP_Ras
		reaction rate (J): ((Kf * Ras_nfpiBRaf) - ((Kr * nfpiBRaf) * GTP_Ras))[molecules.um-2.min-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kfpBr[min-1] reverse rate constant (Kr): 0.0[min-1.uM-1]
nfpiBRafiBRaf	nfpiBRaf_dp cytoplasm	MassAction	nfpiBRafiBRaf
		reaction rate (J): ((Kf * nfpiBRaf) - (Kr * iBRaf))[uM.min-1] forward rate constant (Kf): kdpR1[min-1] reverse rate constant (Kr): 0.0[min-1]
Ras_iRaf1+Ras_iBRafRas_iRaf1_iBRaf1_tetramer	iRaf_iBRaf_dim pm	MassAction	Ras_iRaf1+Ras_iBRafRas_iRaf1_iBRaf1_tetramer
		reaction rate (J): (((Kf * Ras_iRaf1) * Ras_iBRaf) - (Kr * Ras_iRaf1_iBRaf1_tetramer))[molecules.um-2.min-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): kdR1f[um2.min-1.molecules-1] reverse rate constant (Kr): kdR1r[min-1]

Structures See in Dashboard
Name	Type Electrical (Membrane Polarity)
cytoplasm	Compartment (+) (-)

pm	Membrane N/A

Species See in Dashboard
Name	Structure	BioNetGen Definition
sorafenib	cytoplasm

GTP_Ras	pm

Raf1	cytoplasm

pRaf1	cytoplasm

Ras_Raf1	pm

Ras_iRaf1	pm

Ras_pRaf1_Raf1_tetramer	pm

Ras_BRaf	pm

Ras_pRaf1	pm

Ras_BRaf_Raf1_tetramer	pm

Ras_iRaf1_tetramer	pm

iRaf1	cytoplasm

BRaf	cytoplasm

Ras_Braf_iRaf1_tetramer	pm

Ras_pRaf1_tetramer	pm

Ras_BRaf_pRaf1_tetramer	pm

MEK	cytoplasm

pMEK	cytoplasm

ERK	cytoplasm

iBRaf	cytoplasm

Ras_Raf1_iBRaf_tetramer	pm

Ras_pRaf1_iBRaf_tetramer	pm

pERK	cytoplasm

iBRaf_dimer	pm

BRaf_dimer	pm

Ras_iBRaf	pm

Ras_nfpRaf1	pm

nfpRaf1	cytoplasm

Ras_nfpBRaf	pm

nfpBRaf	cytoplasm

BRaf_iBRaf_dimer	pm

Ras_nfpiBRaf	pm

nfpiBRaf	cytoplasm

Ras_nfpiRaf1	pm

nfpiRaf1	cytoplasm

Ras_iRaf1_iBRaf1_tetramer	pm

Molecules See in Dashboard
Name	Text Annotations	BioNetGen Definition

Observables See in Dashboard
Name	Type Count	BioNetGen Definition

Applications See in Dashboard
Name	Math Type	Annotation
-sorafenib	Deterministic (ODE) Compartmental	cloned from 'Raf-1 activation, -sorafenib' owned by user pmyers1995
+sorafenib	Deterministic (ODE) Compartmental	cloned from 'Raf-1 activation, +sorafenib' owned by user pmyers1995 (copied from Raf-1 activation, -sorafenib)
+sorafenib after 60 min EGF pretreatment	Deterministic (ODE) Compartmental	(copied from -sorafenib) cloned from 'Raf-1 activation, -sorafenib' owned by user pmyers1995
+sorafenib after 15 min EGF pretreatment	Deterministic (ODE) Compartmental	(copied from +sorafenib after 60 min EGF pretreatment) (copied from -sorafenib) cloned from 'Raf-1 activation, -sorafenib' owned by user pmyers1995
+sorafenib after 30 min EGF pretreatment	Deterministic (ODE) Compartmental	(copied from Copy of +sorafenib after 60 min EGF pretreatment) (copied from +sorafenib after 60 min EGF pretreatment) (copied from -sorafenib) cloned from 'Raf-1 activation, -sorafenib' owned by user pmyers1995
+sorafenib after 5 min EGF pretreatment	Deterministic (ODE) Compartmental	(copied from Copy of Copy of +sorafenib after 60 min EGF pretreatment) (copied from Copy of +sorafenib after 60 min EGF pretreatment) (copied from +sorafenib after 60 min EGF pretreatment) (copied from -sorafenib) cloned from 'Raf-1 activation, -sorafenib' owned by user pmyers1995
const. active Ras-GTP, -sorafenib	Deterministic (ODE) Compartmental	(copied from -sorafenib) cloned from 'Raf-1 activation, -sorafenib' owned by user pmyers1995

Specifications(Species) - -sorafenib See in Dashboard
Species	Initial Condition	Diffusion Constant
sorafenib	0.0 [uM]	0.0 [um2/min]
Raf1	12000.0 [uM]	0.0 [um2/min]
pRaf1	0.0 [uM]	0.0 [um2/min]
iRaf1	0.0 [uM]	0.0 [um2/min]
BRaf	1000.0 [uM]	0.0 [um2/min]
MEK	500000.0 [uM]	0.0 [um2/min]
pMEK	0.0 [uM]	0.0 [um2/min]
ERK	600000.0 [uM]	0.0 [um2/min]
iBRaf	0.0 [uM]	0.0 [um2/min]
pERK	0.0 [uM]	0.0 [um2/min]
nfpRaf1	0.0 [uM]	0.0 [um2/min]
nfpBRaf	0.0 [uM]	0.0 [um2/min]
nfpiBRaf	0.0 [uM]	0.0 [um2/min]
nfpiRaf1	0.0 [uM]	0.0 [um2/min]
GTP_Ras	((A * t * exp(( - t / B))) + (C * t / (t + D))) [uM]	0.0 [um2/min]
Ras_Raf1	0.0 [uM]	0.0 [um2/min]
Ras_iRaf1	0.0 [uM]	0.0 [um2/min]
Ras_pRaf1_Raf1_tetramer	0.0 [uM]	0.0 [um2/min]
Ras_BRaf	0.0 [uM]	0.0 [um2/min]
Ras_pRaf1	0.0 [uM]	0.0 [um2/min]
Ras_BRaf_Raf1_tetramer	0.0 [uM]	0.0 [um2/min]
Ras_iRaf1_tetramer	0.0 [uM]	0.0 [um2/min]
Ras_Braf_iRaf1_tetramer	0.0 [uM]	0.0 [um2/min]
Ras_pRaf1_tetramer	0.0 [uM]	0.0 [um2/min]
Ras_BRaf_pRaf1_tetramer	0.0 [uM]	0.0 [um2/min]
Ras_Raf1_iBRaf_tetramer	0.0 [uM]	0.0 [um2/min]
Ras_pRaf1_iBRaf_tetramer	0.0 [uM]	0.0 [um2/min]
iBRaf_dimer	0.0 [uM]	0.0 [um2/min]
BRaf_dimer	0.0 [uM]	0.0 [um2/min]
Ras_iBRaf	0.0 [uM]	0.0 [um2/min]
Ras_nfpRaf1	0.0 [uM]	0.0 [um2/min]
Ras_nfpBRaf	0.0 [uM]	0.0 [um2/min]
BRaf_iBRaf_dimer	0.0 [uM]	0.0 [um2/min]
Ras_nfpiBRaf	0.0 [uM]	0.0 [um2/min]
Ras_nfpiRaf1	0.0 [uM]	0.0 [um2/min]
Ras_iRaf1_iBRaf1_tetramer	0.0 [uM]	0.0 [um2/min]

Specifications(Reaction) - -sorafenib See in Dashboard
Name	Reaction Mapping
Ras_Raf1_bind	included
BRaf_Raf1_bind	included
BRaf_Raf1_phosph	included
Ras_pRaf1_unbind	included
Ras_BRaf_bind	included
pRaf1_Raf1_bind	included
pRaf1_Raf1_phosph	included
sorafenib_Raf1_bind_cyt	excluded
Ras_iRaf1_bind	excluded
iRaf1_iRaf1_bind	excluded
BRaf_iRaf1_bind	excluded
pRaf1_dephosph	included
pRaf1_pRaf1_unbind	included
BRaf_pRaf1_unbind	included
sorafenib_BRaf_bind_cyt	excluded
MEK_p	included
MEK_dp	included
ERK_p	included
ERK_dp	included
Ras_iBRaf_b	excluded
iBRaf_dim	excluded
iBRaf_Raf1_bind	excluded
Raf1_iBRaf_p	excluded
pRaf1_iBRaf_ub	excluded
BRaf_dim	included
Ras_pRaf1_dp	included
Ras_Raf1_nfp	included
nfpRaf1_ub	included
nfpRaf1_dp	included
BRaf_nfp	included
nfpBRaf_ub	included
nfpBRaf_dp	included
BRaf_iBRaf_dim	excluded
Ras_iRaf_nfp	excluded
nfpiRaf1_ub	excluded
nfpiRaf_dp	excluded
Ras_iBRaf_nfp	excluded
nfpiBRaf_ub	excluded
nfpiBRaf_dp	excluded
iRaf_iBRaf_dim	excluded

Simulations - -sorafenib See in Dashboard
Name	End Time	Output Options
60 min	60.0 [min]	KeepEvery 1 KeepAtMost 1000
Fitted binding rates	60.0 [min]	KeepEvery 1 KeepAtMost 1000

Geometry non-spatial1069339151 See in Dashboard
(Origin: 0.0, 0.0, 0.0; Extent: 10.0, 10.0, 10.0[um])
Dimension	Type	Subdomain	Adjacent Subvolumes	Size	Mapped Compartment
	Compartmental	Compartment			pm

Specifications(Species) - +sorafenib See in Dashboard
Species	Initial Condition	Diffusion Constant
sorafenib	10.0 [uM]	0.0 [um2/min]
Raf1	12000.0 [uM]	0.0 [um2/min]
pRaf1	0.0 [uM]	0.0 [um2/min]
iRaf1	0.0 [uM]	0.0 [um2/min]
BRaf	1000.0 [uM]	0.0 [um2/min]
MEK	500000.0 [uM]	0.0 [um2/min]
pMEK	0.0 [uM]	0.0 [um2/min]
ERK	600000.0 [uM]	0.0 [um2/min]
iBRaf	0.0 [uM]	0.0 [um2/min]
pERK	0.0 [uM]	0.0 [um2/min]
nfpRaf1	0.0 [uM]	0.0 [um2/min]
nfpBRaf	0.0 [uM]	0.0 [um2/min]
nfpiBRaf	0.0 [uM]	0.0 [um2/min]
nfpiRaf1	0.0 [uM]	0.0 [um2/min]
GTP_Ras	((As * t * exp(( - t / Bs))) + (Cs * t / (t + Ds))) [uM]	0.0 [um2/min]
Ras_Raf1	0.0 [uM]	0.0 [um2/min]
Ras_iRaf1	0.0 [uM]	0.0 [um2/min]
Ras_pRaf1_Raf1_tetramer	0.0 [uM]	0.0 [um2/min]
Ras_BRaf	0.0 [uM]	0.0 [um2/min]
Ras_pRaf1	0.0 [uM]	0.0 [um2/min]
Ras_BRaf_Raf1_tetramer	0.0 [uM]	0.0 [um2/min]
Ras_iRaf1_tetramer	0.0 [uM]	0.0 [um2/min]
Ras_Braf_iRaf1_tetramer	0.0 [uM]	0.0 [um2/min]
Ras_pRaf1_tetramer	0.0 [uM]	0.0 [um2/min]
Ras_BRaf_pRaf1_tetramer	0.0 [uM]	0.0 [um2/min]
Ras_Raf1_iBRaf_tetramer	0.0 [uM]	0.0 [um2/min]
Ras_pRaf1_iBRaf_tetramer	0.0 [uM]	0.0 [um2/min]
iBRaf_dimer	0.0 [uM]	0.0 [um2/min]
BRaf_dimer	0.0 [uM]	0.0 [um2/min]
Ras_iBRaf	0.0 [uM]	0.0 [um2/min]
Ras_nfpRaf1	0.0 [uM]	0.0 [um2/min]
Ras_nfpBRaf	0.0 [uM]	0.0 [um2/min]
BRaf_iBRaf_dimer	0.0 [uM]	0.0 [um2/min]
Ras_nfpiBRaf	0.0 [uM]	0.0 [um2/min]
Ras_nfpiRaf1	0.0 [uM]	0.0 [um2/min]
Ras_iRaf1_iBRaf1_tetramer	0.0 [uM]	0.0 [um2/min]

Specifications(Reaction) - +sorafenib See in Dashboard
Name	Reaction Mapping
Ras_Raf1_bind	included
BRaf_Raf1_bind	included
BRaf_Raf1_phosph	included
Ras_pRaf1_unbind	included
Ras_BRaf_bind	included
pRaf1_Raf1_bind	included
pRaf1_Raf1_phosph	included
sorafenib_Raf1_bind_cyt	included
Ras_iRaf1_bind	included
iRaf1_iRaf1_bind	included
BRaf_iRaf1_bind	included
pRaf1_dephosph	included
pRaf1_pRaf1_unbind	included
BRaf_pRaf1_unbind	included
sorafenib_BRaf_bind_cyt	included
MEK_p	included
MEK_dp	included
ERK_p	included
ERK_dp	included
Ras_iBRaf_b	included
iBRaf_dim	included
iBRaf_Raf1_bind	included
Raf1_iBRaf_p	included
pRaf1_iBRaf_ub	included
BRaf_dim	included
Ras_pRaf1_dp	included
Ras_Raf1_nfp	included
nfpRaf1_ub	included
nfpRaf1_dp	included
BRaf_nfp	included
nfpBRaf_ub	included
nfpBRaf_dp	included
BRaf_iBRaf_dim	included
Ras_iRaf_nfp	included
nfpiRaf1_ub	included
nfpiRaf_dp	included
Ras_iBRaf_nfp	included
nfpiBRaf_ub	included
nfpiBRaf_dp	included
iRaf_iBRaf_dim	included

Simulations - +sorafenib See in Dashboard
Name	End Time	Output Options
Fitted binding	60.0 [min]	KeepEvery 1 KeepAtMost 1000

Geometry non-spatial1102832951 See in Dashboard
(Origin: 0.0, 0.0, 0.0; Extent: 10.0, 10.0, 10.0[um])
Dimension	Type	Subdomain	Adjacent Subvolumes	Size	Mapped Compartment
	Compartmental	Compartment			pm

Specifications(Species) - +sorafenib after 60 min EGF pretreatment See in Dashboard
Species	Initial Condition	Diffusion Constant
sorafenib	(10.0 * (t > 60.0)) [uM]	0.0 [um2/min]
Raf1	12000.0 [uM]	0.0 [um2/min]
pRaf1	0.0 [uM]	0.0 [um2/min]
iRaf1	0.0 [uM]	0.0 [um2/min]
BRaf	1000.0 [uM]	0.0 [um2/min]
MEK	500000.0 [uM]	0.0 [um2/min]
pMEK	0.0 [uM]	0.0 [um2/min]
ERK	600000.0 [uM]	0.0 [um2/min]
iBRaf	0.0 [uM]	0.0 [um2/min]
pERK	0.0 [uM]	0.0 [um2/min]
nfpRaf1	0.0 [uM]	0.0 [um2/min]
nfpBRaf	0.0 [uM]	0.0 [um2/min]
nfpiBRaf	0.0 [uM]	0.0 [um2/min]
nfpiRaf1	0.0 [uM]	0.0 [um2/min]
GTP_Ras	((A * t * exp(( - t / B))) + (C * t / (t + D))) [uM]	0.0 [um2/min]
Ras_Raf1	0.0 [uM]	0.0 [um2/min]
Ras_iRaf1	0.0 [uM]	0.0 [um2/min]
Ras_pRaf1_Raf1_tetramer	0.0 [uM]	0.0 [um2/min]
Ras_BRaf	0.0 [uM]	0.0 [um2/min]
Ras_pRaf1	0.0 [uM]	0.0 [um2/min]
Ras_BRaf_Raf1_tetramer	0.0 [uM]	0.0 [um2/min]
Ras_iRaf1_tetramer	0.0 [uM]	0.0 [um2/min]
Ras_Braf_iRaf1_tetramer	0.0 [uM]	0.0 [um2/min]
Ras_pRaf1_tetramer	0.0 [uM]	0.0 [um2/min]
Ras_BRaf_pRaf1_tetramer	0.0 [uM]	0.0 [um2/min]
Ras_Raf1_iBRaf_tetramer	0.0 [uM]	0.0 [um2/min]
Ras_pRaf1_iBRaf_tetramer	0.0 [uM]	0.0 [um2/min]
iBRaf_dimer	0.0 [uM]	0.0 [um2/min]
BRaf_dimer	0.0 [uM]	0.0 [um2/min]
Ras_iBRaf	0.0 [uM]	0.0 [um2/min]
Ras_nfpRaf1	0.0 [uM]	0.0 [um2/min]
Ras_nfpBRaf	0.0 [uM]	0.0 [um2/min]
BRaf_iBRaf_dimer	0.0 [uM]	0.0 [um2/min]
Ras_nfpiBRaf	0.0 [uM]	0.0 [um2/min]
Ras_nfpiRaf1	0.0 [uM]	0.0 [um2/min]
Ras_iRaf1_iBRaf1_tetramer	0.0 [uM]	0.0 [um2/min]

Specifications(Reaction) - +sorafenib after 60 min EGF pretreatment See in Dashboard
Name	Reaction Mapping
Ras_Raf1_bind	included
BRaf_Raf1_bind	included
BRaf_Raf1_phosph	included
Ras_pRaf1_unbind	included
Ras_BRaf_bind	included
pRaf1_Raf1_bind	included
pRaf1_Raf1_phosph	included
sorafenib_Raf1_bind_cyt	included
Ras_iRaf1_bind	included
iRaf1_iRaf1_bind	included
BRaf_iRaf1_bind	included
pRaf1_dephosph	included
pRaf1_pRaf1_unbind	included
BRaf_pRaf1_unbind	included
sorafenib_BRaf_bind_cyt	included
MEK_p	included
MEK_dp	included
ERK_p	included
ERK_dp	included
Ras_iBRaf_b	included
iBRaf_dim	included
iBRaf_Raf1_bind	included
Raf1_iBRaf_p	included
pRaf1_iBRaf_ub	included
BRaf_dim	included
Ras_pRaf1_dp	included
Ras_Raf1_nfp	included
nfpRaf1_ub	included
nfpRaf1_dp	included
BRaf_nfp	included
nfpBRaf_ub	included
nfpBRaf_dp	included
BRaf_iBRaf_dim	included
Ras_iRaf_nfp	included
nfpiRaf1_ub	included
nfpiRaf_dp	included
Ras_iBRaf_nfp	included
nfpiBRaf_ub	included
nfpiBRaf_dp	included
iRaf_iBRaf_dim	included

Simulations - +sorafenib after 60 min EGF pretreatment See in Dashboard
Name	End Time	Output Options
60 min EGF pretreat	80.0 [min]	KeepEvery 1 KeepAtMost 1000

Geometry non-spatial1069339151 See in Dashboard
(Origin: 0.0, 0.0, 0.0; Extent: 10.0, 10.0, 10.0[um])
Dimension	Type	Subdomain	Adjacent Subvolumes	Size	Mapped Compartment
	Compartmental	Compartment			pm

Specifications(Species) - +sorafenib after 15 min EGF pretreatment See in Dashboard
Species	Initial Condition	Diffusion Constant
sorafenib	(10.0 * (t > 15.0)) [uM]	0.0 [um2/min]
Raf1	12000.0 [uM]	0.0 [um2/min]
pRaf1	0.0 [uM]	0.0 [um2/min]
iRaf1	0.0 [uM]	0.0 [um2/min]
BRaf	1000.0 [uM]	0.0 [um2/min]
MEK	500000.0 [uM]	0.0 [um2/min]
pMEK	0.0 [uM]	0.0 [um2/min]
ERK	600000.0 [uM]	0.0 [um2/min]
iBRaf	0.0 [uM]	0.0 [um2/min]
pERK	0.0 [uM]	0.0 [um2/min]
nfpRaf1	0.0 [uM]	0.0 [um2/min]
nfpBRaf	0.0 [uM]	0.0 [um2/min]
nfpiBRaf	0.0 [uM]	0.0 [um2/min]
nfpiRaf1	0.0 [uM]	0.0 [um2/min]
GTP_Ras	((A * t * exp(( - t / B))) + (C * t / (t + D))) [uM]	0.0 [um2/min]
Ras_Raf1	0.0 [uM]	0.0 [um2/min]
Ras_iRaf1	0.0 [uM]	0.0 [um2/min]
Ras_pRaf1_Raf1_tetramer	0.0 [uM]	0.0 [um2/min]
Ras_BRaf	0.0 [uM]	0.0 [um2/min]
Ras_pRaf1	0.0 [uM]	0.0 [um2/min]
Ras_BRaf_Raf1_tetramer	0.0 [uM]	0.0 [um2/min]
Ras_iRaf1_tetramer	0.0 [uM]	0.0 [um2/min]
Ras_Braf_iRaf1_tetramer	0.0 [uM]	0.0 [um2/min]
Ras_pRaf1_tetramer	0.0 [uM]	0.0 [um2/min]
Ras_BRaf_pRaf1_tetramer	0.0 [uM]	0.0 [um2/min]
Ras_Raf1_iBRaf_tetramer	0.0 [uM]	0.0 [um2/min]
Ras_pRaf1_iBRaf_tetramer	0.0 [uM]	0.0 [um2/min]
iBRaf_dimer	0.0 [uM]	0.0 [um2/min]
BRaf_dimer	0.0 [uM]	0.0 [um2/min]
Ras_iBRaf	0.0 [uM]	0.0 [um2/min]
Ras_nfpRaf1	0.0 [uM]	0.0 [um2/min]
Ras_nfpBRaf	0.0 [uM]	0.0 [um2/min]
BRaf_iBRaf_dimer	0.0 [uM]	0.0 [um2/min]
Ras_nfpiBRaf	0.0 [uM]	0.0 [um2/min]
Ras_nfpiRaf1	0.0 [uM]	0.0 [um2/min]
Ras_iRaf1_iBRaf1_tetramer	0.0 [uM]	0.0 [um2/min]

Specifications(Reaction) - +sorafenib after 15 min EGF pretreatment See in Dashboard
Name	Reaction Mapping
Ras_Raf1_bind	included
BRaf_Raf1_bind	included
BRaf_Raf1_phosph	included
Ras_pRaf1_unbind	included
Ras_BRaf_bind	included
pRaf1_Raf1_bind	included
pRaf1_Raf1_phosph	included
sorafenib_Raf1_bind_cyt	included
Ras_iRaf1_bind	included
iRaf1_iRaf1_bind	included
BRaf_iRaf1_bind	included
pRaf1_dephosph	included
pRaf1_pRaf1_unbind	included
BRaf_pRaf1_unbind	included
sorafenib_BRaf_bind_cyt	included
MEK_p	included
MEK_dp	included
ERK_p	included
ERK_dp	included
Ras_iBRaf_b	included
iBRaf_dim	included
iBRaf_Raf1_bind	included
Raf1_iBRaf_p	included
pRaf1_iBRaf_ub	included
BRaf_dim	included
Ras_pRaf1_dp	included
Ras_Raf1_nfp	included
nfpRaf1_ub	included
nfpRaf1_dp	included
BRaf_nfp	included
nfpBRaf_ub	included
nfpBRaf_dp	included
BRaf_iBRaf_dim	included
Ras_iRaf_nfp	included
nfpiRaf1_ub	included
nfpiRaf_dp	included
Ras_iBRaf_nfp	included
nfpiBRaf_ub	included
nfpiBRaf_dp	included
iRaf_iBRaf_dim	included

Simulations - +sorafenib after 15 min EGF pretreatment See in Dashboard
Name	End Time	Output Options
15 min EGF pretreat	35.0 [min]	KeepEvery 1 KeepAtMost 1000

Geometry non-spatial1069339151 See in Dashboard
(Origin: 0.0, 0.0, 0.0; Extent: 10.0, 10.0, 10.0[um])
Dimension	Type	Subdomain	Adjacent Subvolumes	Size	Mapped Compartment
	Compartmental	Compartment			pm

Specifications(Species) - +sorafenib after 30 min EGF pretreatment See in Dashboard
Species	Initial Condition	Diffusion Constant
sorafenib	(10.0 * (t > 30.0)) [uM]	0.0 [um2/min]
Raf1	12000.0 [uM]	0.0 [um2/min]
pRaf1	0.0 [uM]	0.0 [um2/min]
iRaf1	0.0 [uM]	0.0 [um2/min]
BRaf	1000.0 [uM]	0.0 [um2/min]
MEK	500000.0 [uM]	0.0 [um2/min]
pMEK	0.0 [uM]	0.0 [um2/min]
ERK	600000.0 [uM]	0.0 [um2/min]
iBRaf	0.0 [uM]	0.0 [um2/min]
pERK	0.0 [uM]	0.0 [um2/min]
nfpRaf1	0.0 [uM]	0.0 [um2/min]
nfpBRaf	0.0 [uM]	0.0 [um2/min]
nfpiBRaf	0.0 [uM]	0.0 [um2/min]
nfpiRaf1	0.0 [uM]	0.0 [um2/min]
GTP_Ras	((A * t * exp(( - t / B))) + (C * t / (t + D))) [uM]	0.0 [um2/min]
Ras_Raf1	0.0 [uM]	0.0 [um2/min]
Ras_iRaf1	0.0 [uM]	0.0 [um2/min]
Ras_pRaf1_Raf1_tetramer	0.0 [uM]	0.0 [um2/min]
Ras_BRaf	0.0 [uM]	0.0 [um2/min]
Ras_pRaf1	0.0 [uM]	0.0 [um2/min]
Ras_BRaf_Raf1_tetramer	0.0 [uM]	0.0 [um2/min]
Ras_iRaf1_tetramer	0.0 [uM]	0.0 [um2/min]
Ras_Braf_iRaf1_tetramer	0.0 [uM]	0.0 [um2/min]
Ras_pRaf1_tetramer	0.0 [uM]	0.0 [um2/min]
Ras_BRaf_pRaf1_tetramer	0.0 [uM]	0.0 [um2/min]
Ras_Raf1_iBRaf_tetramer	0.0 [uM]	0.0 [um2/min]
Ras_pRaf1_iBRaf_tetramer	0.0 [uM]	0.0 [um2/min]
iBRaf_dimer	0.0 [uM]	0.0 [um2/min]
BRaf_dimer	0.0 [uM]	0.0 [um2/min]
Ras_iBRaf	0.0 [uM]	0.0 [um2/min]
Ras_nfpRaf1	0.0 [uM]	0.0 [um2/min]
Ras_nfpBRaf	0.0 [uM]	0.0 [um2/min]
BRaf_iBRaf_dimer	0.0 [uM]	0.0 [um2/min]
Ras_nfpiBRaf	0.0 [uM]	0.0 [um2/min]
Ras_nfpiRaf1	0.0 [uM]	0.0 [um2/min]
Ras_iRaf1_iBRaf1_tetramer	0.0 [uM]	0.0 [um2/min]

Specifications(Reaction) - +sorafenib after 30 min EGF pretreatment See in Dashboard
Name	Reaction Mapping
Ras_Raf1_bind	included
BRaf_Raf1_bind	included
BRaf_Raf1_phosph	included
Ras_pRaf1_unbind	included
Ras_BRaf_bind	included
pRaf1_Raf1_bind	included
pRaf1_Raf1_phosph	included
sorafenib_Raf1_bind_cyt	included
Ras_iRaf1_bind	included
iRaf1_iRaf1_bind	included
BRaf_iRaf1_bind	included
pRaf1_dephosph	included
pRaf1_pRaf1_unbind	included
BRaf_pRaf1_unbind	included
sorafenib_BRaf_bind_cyt	included
MEK_p	included
MEK_dp	included
ERK_p	included
ERK_dp	included
Ras_iBRaf_b	included
iBRaf_dim	included
iBRaf_Raf1_bind	included
Raf1_iBRaf_p	included
pRaf1_iBRaf_ub	included
BRaf_dim	included
Ras_pRaf1_dp	included
Ras_Raf1_nfp	included
nfpRaf1_ub	included
nfpRaf1_dp	included
BRaf_nfp	included
nfpBRaf_ub	included
nfpBRaf_dp	included
BRaf_iBRaf_dim	included
Ras_iRaf_nfp	included
nfpiRaf1_ub	included
nfpiRaf_dp	included
Ras_iBRaf_nfp	included
nfpiBRaf_ub	included
nfpiBRaf_dp	included
iRaf_iBRaf_dim	included

Simulations - +sorafenib after 30 min EGF pretreatment See in Dashboard
Name	End Time	Output Options
30 min EGF pretreat	50.0 [min]	KeepEvery 1 KeepAtMost 1000

Geometry non-spatial1069339151 See in Dashboard
(Origin: 0.0, 0.0, 0.0; Extent: 10.0, 10.0, 10.0[um])
Dimension	Type	Subdomain	Adjacent Subvolumes	Size	Mapped Compartment
	Compartmental	Compartment			pm

Specifications(Species) - +sorafenib after 5 min EGF pretreatment See in Dashboard
Species	Initial Condition	Diffusion Constant
sorafenib	(10.0 * (t > 5.0)) [uM]	0.0 [um2/min]
Raf1	12000.0 [uM]	0.0 [um2/min]
pRaf1	0.0 [uM]	0.0 [um2/min]
iRaf1	0.0 [uM]	0.0 [um2/min]
BRaf	1000.0 [uM]	0.0 [um2/min]
MEK	500000.0 [uM]	0.0 [um2/min]
pMEK	0.0 [uM]	0.0 [um2/min]
ERK	600000.0 [uM]	0.0 [um2/min]
iBRaf	0.0 [uM]	0.0 [um2/min]
pERK	0.0 [uM]	0.0 [um2/min]
nfpRaf1	0.0 [uM]	0.0 [um2/min]
nfpBRaf	0.0 [uM]	0.0 [um2/min]
nfpiBRaf	0.0 [uM]	0.0 [um2/min]
nfpiRaf1	0.0 [uM]	0.0 [um2/min]
GTP_Ras	((A * t * exp(( - t / B))) + (C * t / (t + D))) [uM]	0.0 [um2/min]
Ras_Raf1	0.0 [uM]	0.0 [um2/min]
Ras_iRaf1	0.0 [uM]	0.0 [um2/min]
Ras_pRaf1_Raf1_tetramer	0.0 [uM]	0.0 [um2/min]
Ras_BRaf	0.0 [uM]	0.0 [um2/min]
Ras_pRaf1	0.0 [uM]	0.0 [um2/min]
Ras_BRaf_Raf1_tetramer	0.0 [uM]	0.0 [um2/min]
Ras_iRaf1_tetramer	0.0 [uM]	0.0 [um2/min]
Ras_Braf_iRaf1_tetramer	0.0 [uM]	0.0 [um2/min]
Ras_pRaf1_tetramer	0.0 [uM]	0.0 [um2/min]
Ras_BRaf_pRaf1_tetramer	0.0 [uM]	0.0 [um2/min]
Ras_Raf1_iBRaf_tetramer	0.0 [uM]	0.0 [um2/min]
Ras_pRaf1_iBRaf_tetramer	0.0 [uM]	0.0 [um2/min]
iBRaf_dimer	0.0 [uM]	0.0 [um2/min]
BRaf_dimer	0.0 [uM]	0.0 [um2/min]
Ras_iBRaf	0.0 [uM]	0.0 [um2/min]
Ras_nfpRaf1	0.0 [uM]	0.0 [um2/min]
Ras_nfpBRaf	0.0 [uM]	0.0 [um2/min]
BRaf_iBRaf_dimer	0.0 [uM]	0.0 [um2/min]
Ras_nfpiBRaf	0.0 [uM]	0.0 [um2/min]
Ras_nfpiRaf1	0.0 [uM]	0.0 [um2/min]
Ras_iRaf1_iBRaf1_tetramer	0.0 [uM]	0.0 [um2/min]

Specifications(Reaction) - +sorafenib after 5 min EGF pretreatment See in Dashboard
Name	Reaction Mapping
Ras_Raf1_bind	included
BRaf_Raf1_bind	included
BRaf_Raf1_phosph	included
Ras_pRaf1_unbind	included
Ras_BRaf_bind	included
pRaf1_Raf1_bind	included
pRaf1_Raf1_phosph	included
sorafenib_Raf1_bind_cyt	included
Ras_iRaf1_bind	included
iRaf1_iRaf1_bind	included
BRaf_iRaf1_bind	included
pRaf1_dephosph	included
pRaf1_pRaf1_unbind	included
BRaf_pRaf1_unbind	included
sorafenib_BRaf_bind_cyt	included
MEK_p	included
MEK_dp	included
ERK_p	included
ERK_dp	included
Ras_iBRaf_b	included
iBRaf_dim	included
iBRaf_Raf1_bind	included
Raf1_iBRaf_p	included
pRaf1_iBRaf_ub	included
BRaf_dim	included
Ras_pRaf1_dp	included
Ras_Raf1_nfp	included
nfpRaf1_ub	included
nfpRaf1_dp	included
BRaf_nfp	included
nfpBRaf_ub	included
nfpBRaf_dp	included
BRaf_iBRaf_dim	included
Ras_iRaf_nfp	included
nfpiRaf1_ub	included
nfpiRaf_dp	included
Ras_iBRaf_nfp	included
nfpiBRaf_ub	included
nfpiBRaf_dp	included
iRaf_iBRaf_dim	included

Simulations - +sorafenib after 5 min EGF pretreatment See in Dashboard
Name	End Time	Output Options
5 min EGF pretreat	25.0 [min]	KeepEvery 1 KeepAtMost 1000

Geometry non-spatial1069339151 See in Dashboard
(Origin: 0.0, 0.0, 0.0; Extent: 10.0, 10.0, 10.0[um])
Dimension	Type	Subdomain	Adjacent Subvolumes	Size	Mapped Compartment
	Compartmental	Compartment			pm

Specifications(Species) - const. active Ras-GTP, -sorafenib See in Dashboard
Species	Initial Condition	Diffusion Constant
sorafenib	0.0 [uM]	0.0 [um2/min]
Raf1	12000.0 [uM]	0.0 [um2/min]
pRaf1	0.0 [uM]	0.0 [um2/min]
iRaf1	0.0 [uM]	0.0 [um2/min]
BRaf	1000.0 [uM]	0.0 [um2/min]
MEK	500000.0 [uM]	0.0 [um2/min]
pMEK	0.0 [uM]	0.0 [um2/min]
ERK	600000.0 [uM]	0.0 [um2/min]
iBRaf	0.0 [uM]	0.0 [um2/min]
pERK	0.0 [uM]	0.0 [um2/min]
nfpRaf1	0.0 [uM]	0.0 [um2/min]
nfpBRaf	0.0 [uM]	0.0 [um2/min]
nfpiBRaf	0.0 [uM]	0.0 [um2/min]
nfpiRaf1	0.0 [uM]	0.0 [um2/min]
GTP_Ras	27000.0 [uM]	0.0 [um2/min]
Ras_Raf1	0.0 [uM]	0.0 [um2/min]
Ras_iRaf1	0.0 [uM]	0.0 [um2/min]
Ras_pRaf1_Raf1_tetramer	0.0 [uM]	0.0 [um2/min]
Ras_BRaf	0.0 [uM]	0.0 [um2/min]
Ras_pRaf1	0.0 [uM]	0.0 [um2/min]
Ras_BRaf_Raf1_tetramer	0.0 [uM]	0.0 [um2/min]
Ras_iRaf1_tetramer	0.0 [uM]	0.0 [um2/min]
Ras_Braf_iRaf1_tetramer	0.0 [uM]	0.0 [um2/min]
Ras_pRaf1_tetramer	0.0 [uM]	0.0 [um2/min]
Ras_BRaf_pRaf1_tetramer	0.0 [uM]	0.0 [um2/min]
Ras_Raf1_iBRaf_tetramer	0.0 [uM]	0.0 [um2/min]
Ras_pRaf1_iBRaf_tetramer	0.0 [uM]	0.0 [um2/min]
iBRaf_dimer	0.0 [uM]	0.0 [um2/min]
BRaf_dimer	0.0 [uM]	0.0 [um2/min]
Ras_iBRaf	0.0 [uM]	0.0 [um2/min]
Ras_nfpRaf1	0.0 [uM]	0.0 [um2/min]
Ras_nfpBRaf	0.0 [uM]	0.0 [um2/min]
BRaf_iBRaf_dimer	0.0 [uM]	0.0 [um2/min]
Ras_nfpiBRaf	0.0 [uM]	0.0 [um2/min]
Ras_nfpiRaf1	0.0 [uM]	0.0 [um2/min]
Ras_iRaf1_iBRaf1_tetramer	0.0 [uM]	0.0 [um2/min]

Specifications(Reaction) - const. active Ras-GTP, -sorafenib See in Dashboard
Name	Reaction Mapping
Ras_Raf1_bind	included
BRaf_Raf1_bind	included
BRaf_Raf1_phosph	included
Ras_pRaf1_unbind	included
Ras_BRaf_bind	included
pRaf1_Raf1_bind	included
pRaf1_Raf1_phosph	included
sorafenib_Raf1_bind_cyt	excluded
Ras_iRaf1_bind	excluded
iRaf1_iRaf1_bind	excluded
BRaf_iRaf1_bind	excluded
pRaf1_dephosph	included
pRaf1_pRaf1_unbind	included
BRaf_pRaf1_unbind	included
sorafenib_BRaf_bind_cyt	included
MEK_p	included
MEK_dp	included
ERK_p	included
ERK_dp	included
Ras_iBRaf_b	excluded
iBRaf_dim	excluded
iBRaf_Raf1_bind	excluded
Raf1_iBRaf_p	excluded
pRaf1_iBRaf_ub	excluded
BRaf_dim	included
Ras_pRaf1_dp	included
Ras_Raf1_nfp	included
nfpRaf1_ub	included
nfpRaf1_dp	included
BRaf_nfp	included
nfpBRaf_ub	included
nfpBRaf_dp	included
BRaf_iBRaf_dim	excluded
Ras_iRaf_nfp	excluded
nfpiRaf1_ub	excluded
nfpiRaf_dp	excluded
Ras_iBRaf_nfp	excluded
nfpiBRaf_ub	excluded
nfpiBRaf_dp	excluded
iRaf_iBRaf_dim	excluded

Simulations - const. active Ras-GTP, -sorafenib See in Dashboard
Name	End Time	Output Options
Simulation0	60.0 [min]	KeepEvery 1 KeepAtMost 1000
10x Ras	60.0 [min]	KeepEvery 1 KeepAtMost 1000

Geometry non-spatial757173534 See in Dashboard
(Origin: 0.0, 0.0, 0.0; Extent: 10.0, 10.0, 10.0[um])
Dimension	Type	Subdomain	Adjacent Subvolumes	Size	Mapped Compartment
	Compartmental	Compartment			pm

Global Parameters See in Dashboard
Name	Expression
kSon	100000.0 [uM-1.min-1]

kSoff	420.0 [min-1]

kpR1	186.0 [min-1]

kdR1f	0.0191 [molecules-1.min-1]

kR1f	1.84E-7 [molecules.min-1]

kR1r	0.212 [min-1]

kBf	2.47E-7 [min-1.molecules-1]

kBr	0.0367 [min-1]

kdR1r	111.0 [min-1]

kdpR1	0.6 [min-1]

boundRaf_frac_parameter	(Raf1_pm_param / (Raf1_cyt_param + Raf1_pm_param))[tbd]

A	20671.0 [tbd]

B	3.6724 [tbd]

C	6.7089E16 [tbd]

RasGTP_parameter	(GTP_Ras + (2.0 * (Ras_iRaf1_tetramer + Ras_Braf_iRaf1_tetramer + Ras_BRaf_Raf1_tetramer + Ras_pRaf1_Raf1_tetramer + Ras_BRaf_pRaf1_tetramer + Ras_pRaf1_tetramer + BRaf_dimer + BRaf_iBRaf_dimer + iBRaf_dimer + Ras_iRaf1_iBRaf1_tetramer + Ras_Raf1_iBRaf_tetramer + Ras_pRaf1_iBRaf_tetramer)) + Ras_BRaf + Ras_iRaf1 + Ras_pRaf1 + Ras_Raf1 + Ras_nfpRaf1 + Ras_nfpiRaf1 + Ras_iBRaf + Ras_nfpiBRaf + Ras_nfpBRaf)[tbd]

kiR1f	1.84E-7 [min-1.molecules-1]

kiR1r	0.212 [min-1]

Raf1_pm_param	(Ras_pRaf1 + (2.0 * Ras_pRaf1_Raf1_tetramer) + Ras_BRaf_Raf1_tetramer + Ras_iRaf1 + Ras_Raf1 + (2.0 * Ras_iRaf1_tetramer) + Ras_Braf_iRaf1_tetramer + Ras_BRaf_pRaf1_tetramer + (2.0 * Ras_pRaf1_tetramer) + Ras_nfpiRaf1 + Ras_nfpRaf1 + Ras_iRaf1_iBRaf1_tetramer + Ras_Raf1_iBRaf_tetramer + Ras_pRaf1_iBRaf_tetramer)[tbd]

Raf1_cyt_param	(Raf1 + pRaf1 + iRaf1 + nfpRaf1 + nfpiRaf1)[tbd]

kMEKp	6.0E-6[molecules-1.min-1]

active_Raf	((2.0 * BRaf_dimer) + Ras_BRaf_Raf1_tetramer + (2.0 * Ras_BRaf_pRaf1_tetramer) + Ras_pRaf1_iBRaf_tetramer + Ras_pRaf1 + Ras_pRaf1_Raf1_tetramer + (2.0 * Ras_pRaf1_tetramer) + pRaf1 + BRaf_iBRaf_dimer + Ras_Braf_iRaf1_tetramer)[tbd]

kERKp	6.0E-5[min-1.molecules-1]

kERKdp	0.6[min-1]

kMEKdp	0.6[min-1]

kiBf	2.47E-7[molecules-1.min-1]

kiBr	0.0367[min-1]

kfpR1r	2.12[min-1]

kfpBr	0.367[min-1]

knfpBR1	6.0E-7[min-1.molecules-1]

D	1.1735E15[tbd]

As	21930.665775907[tbd]

Bs	3.30082007598438[tbd]

Cs	5.37755813880742E16[tbd]

Ds	1.42262832362309E15[tbd]

Name - Surve_et_al_RAF1

BioModel ID - 147699816

Reaction Diagram

Physiology

Applications

Application - -sorafenib

Application - +sorafenib

Application - +sorafenib after 60 min EGF pretreatment

Application - +sorafenib after 15 min EGF pretreatment

Application - +sorafenib after 30 min EGF pretreatment

Application - +sorafenib after 5 min EGF pretreatment

Application - const. active Ras-GTP, -sorafenib

Global Parameters