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Name - spatial protection test- no flux two way competition orginal - paper model-shared

BioModel ID - 123269393

Reaction Diagram

reactionDiagram

Physiology

Universal ID's	Text Annotations

Reactions See in Dashboard
Reaction	Name Structure	Kinetics	Depiction
pYA+SH2ApYASH2A	r4 membrane	MassAction	pYA+SH2ApYASH2A
		reaction rate (J): (((Kf * pYA) * SH2A) - (Kr * pYASH2A))[uM.s-1] forward rate constant (Kf): 1.0[s-1.uM-1] reverse rate constant (Kr): 1.0[s-1]
pYA+SH2BpYASH2B	r1 membrane	MassAction	pYA+SH2BpYASH2B
		reaction rate (J): (((Kf * pYA) * SH2B) - (Kr * pYASH2B))[uM.s-1] forward rate constant (Kf): 1.0[s-1.uM-1] reverse rate constant (Kr): 1.0[s-1]

Structures See in Dashboard
Name	Type Electrical (Membrane Polarity)
nuclear membrane	Compartment (+) (-)

cytoplasm	Compartment (+) (-)

extracellular	Compartment (+) (-)

membrane	Compartment (+) (-)

nucleus	Compartment (+) (-)

Species See in Dashboard
Name	Structure	BioNetGen Definition
SH2A	cytoplasm

pYA	membrane

pYASH2A	membrane

pYASH2B	membrane

SH2B	cytoplasm

EGF	extracellular

kinase	membrane

Kinase_EGF	membrane

Molecules See in Dashboard
Name	Text Annotations	BioNetGen Definition

Observables See in Dashboard
Name	Type Count	BioNetGen Definition

Applications

Applications See in Dashboard
Name	Math Type	Annotation
Application2	Deterministic (ODE) Compartmental

Application - Application2

Specifications(Species) - Application2 See in Dashboard
Species	Initial Condition	Diffusion Constant
SH2A	0.24 [uM]	0.0 [um2/s]
SH2B	0.0 [uM]	0.0 [um2/s]
EGF	0.0 [uM]	0.0 [um2/s]
pYA	0.447 [uM]	0.0 [um2/s]
pYASH2A	0.0 [uM]	0.0 [um2/s]
pYASH2B	0.0 [uM]	0.0 [um2/s]
kinase	8.1 [uM]	0.0 [um2/s]
Kinase_EGF	0.0 [uM]	0.0 [um2/s]

Specifications(Reaction) - Application2 See in Dashboard
Name	Reaction Mapping
r4	included
r1	included

Simulations - Application2 See in Dashboard
Name	End Time	Output Options
Simulation1	100.0 [s]	OutputTimeStep 5.0
Copy of Simulation1	100.0 [s]	OutputTimeStep 5.0
Simulation0	100.0 [s]	OutputTimeStep 5.0
Simulation2	1000.0 [s]	OutputTimeStep 5.0
Simulation3	1000.0 [s]	OutputTimeStep 5.0
Simulation4	1000.0 [s]	OutputTimeStep 5.0
Copy of Simulation4	1000.0 [s]	OutputTimeStep 5.0
Copy of Simulation0	100.0 [s]	OutputTimeStep 5.0
Copy of Copy of Simulation0	100.0 [s]	OutputTimeStep 5.0

Geometry non-spatial210953455 See in Dashboard
(Origin: 0.0, 0.0, 0.0; Extent: 10.0, 10.0, 10.0[um])
Dimension	Type	Subdomain	Adjacent Subvolumes	Size	Mapped Compartment
	Compartmental	Compartment			nucleus

Global Parameters

Global Parameters See in Dashboard
Name	Expression