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Name - RS_JBC2016

BioModel ID - 102802266

Reaction Diagram

Physiology

Universal ID's	Text Annotations

Reactions See in Dashboard
Reaction	Name Structure	Kinetics	Depiction
STEP_PKASTEP	r097 IC	HMMIrreversible	STEP_PKASTEP
		reaction rate (J): ((Vmax * STEP_PKA) / (Km + STEP_PKA))[uM.s-1] Km (1/2 max) (Km): 6.0[uM] max reaction rate (Vmax): (Kcat * PP1)[uM.s-1] user defined (Kcat): 5.0[s-1]
STEPSTEP_PKA	r096 IC	HMMIrreversible	STEPSTEP_PKA
		reaction rate (J): ((Vmax * STEP) / (Km + STEP))[uM.s-1] Km (1/2 max) (Km): 25.641[uM] max reaction rate (Vmax): (Kcat * PKA)[uM.s-1] user defined (Kcat): 1.0[s-1]
ATPcAMP	r010 PM	HMMIrreversible	ATPcAMP
		reaction rate (J): ((Vmax * ATP) / (Km + ATP))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] Km (1/2 max) (Km): 315.0[uM] max reaction rate (Vmax): (Kcat * AC5_Ga)[molecules.um-2.s-1] user defined (Kcat): 8.5[s-1]
ERK_activeERK_Tyr	r093 IC	HMMIrreversible	ERK_activeERK_Tyr
		reaction rate (J): ((Vmax * ERK_active) / (Km + ERK_active))[uM.s-1] Km (1/2 max) (Km): 0.77[uM] max reaction rate (Vmax): (Kcat * PP2A)[uM.s-1] user defined (Kcat): 0.636[s-1]
ERK_TyrERK	r094 IC	HMMIrreversible	ERK_TyrERK
		reaction rate (J): ((Vmax * ERK_Tyr) / (Km + ERK_Tyr))[uM.s-1] Km (1/2 max) (Km): 0.46[uM] max reaction rate (Vmax): (Kcat * STEP)[uM.s-1] user defined (Kcat): 1.06[s-1]
PDE1_cAMPPDE1+AMP	r027 IC	MassAction	PDE1_cAMPPDE1+AMP
		reaction rate (J): ((Kf * PDE1_cAMP) - ((Kr * PDE1) * AMP))[uM.s-1] forward rate constant (Kf): 4.73[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1]
R2C2_cAMP4PKA+R2C_cAMP4	r044 IC	MassAction	R2C2_cAMP4PKA+R2C_cAMP4
		reaction rate (J): ((Kf * R2C2_cAMP4) - ((Kr * PKA) * R2C_cAMP4))[uM.s-1] forward rate constant (Kf): 0.05[s-1] reverse rate constant (Kr): 0.085[s-1.uM-1]
DARPP32_Pi_PP1PP1+DARPP32	r073 IC	MassAction	DARPP32_Pi_PP1PP1+DARPP32
		reaction rate (J): ((Kf * DARPP32_Pi_PP1) - ((Kr * PP1) * DARPP32))[uM.s-1] forward rate constant (Kf): 10.0[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1]
PDE1+MMPXPDE1_inhibited	r051 IC	MassAction	PDE1+MMPXPDE1_inhibited
		reaction rate (J): (((Kf * PDE1) * MMPX) - (Kr * PDE1_inhibited))[uM.s-1] forward rate constant (Kf): 1.0[s-1.uM-1] reverse rate constant (Kr): 1.2[s-1]
DARPP32DARPP32_Pi	r070 IC	HMMIrreversible	DARPP32DARPP32_Pi
		reaction rate (J): ((Vmax * DARPP32) / (Km + DARPP32))[uM.s-1] Km (1/2 max) (Km): 2.4[uM] max reaction rate (Vmax): (Kcat * PKA)[uM.s-1] user defined (Kcat): 2.7[s-1]
DARPP32_Pi+PP1DARPP32_Pi_PP1	r071 IC	MassAction	DARPP32_Pi+PP1DARPP32_Pi_PP1
		reaction rate (J): (((Kf * DARPP32_Pi) * PP1) - (Kr * DARPP32_Pi_PP1))[uM.s-1] forward rate constant (Kf): 100.0[s-1.uM-1] reverse rate constant (Kr): 0.2[s-1]
PDE2_active+cGMPPDE2_active_cGMP	r019 IC	MassAction	PDE2_active+cGMPPDE2_active_cGMP
		reaction rate (J): (((Kf * PDE2_active) * cGMP) - (Kr * PDE2_active_cGMP))[uM.s-1] forward rate constant (Kf): 10.7[s-1.uM-1] reverse rate constant (Kr): 86.0[s-1]
PDE2+Bay60PDE2_inhibited	r054 IC	MassAction	PDE2+Bay60PDE2_inhibited
		reaction rate (J): (((Kf * PDE2) * Bay60) - (Kr * PDE2_inhibited))[uM.s-1] forward rate constant (Kf): 1.0[s-1.uM-1] reverse rate constant (Kr): 0.01[s-1]
PDE2_active_cAMP+Bay60PDE2_inhibited	r058 IC	MassAction	PDE2_active_cAMP+Bay60PDE2_inhibited
		reaction rate (J): (((Kf * PDE2_active_cAMP) * Bay60) - (Kr * PDE2_inhibited))[uM.s-1] forward rate constant (Kf): 1.0[s-1.uM-1] reverse rate constant (Kr): 0.01[s-1]
Gaby+D1RD1R_Gaby	r001 PM	MassAction	Gaby+D1RD1R_Gaby
		reaction rate (J): (((Kf * Gaby) * D1R) - (Kr * D1R_Gaby))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): 0.06[um2.s-1.molecules-1] reverse rate constant (Kr): 3.0E-4[s-1]
PDE1_cGMPGMP+PDE1	r029 IC	MassAction	PDE1_cGMPGMP+PDE1
		reaction rate (J): ((Kf * PDE1_cGMP) - ((Kr * GMP) * PDE1))[uM.s-1] forward rate constant (Kf): 8.4[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1]
PDE2_active_cGMP+Bay60PDE2_inhibited	r059 IC	MassAction	PDE2_active_cGMP+Bay60PDE2_inhibited
		reaction rate (J): (((Kf * PDE2_active_cGMP) * Bay60) - (Kr * PDE2_inhibited))[uM.s-1] forward rate constant (Kf): 1.0[s-1.uM-1] reverse rate constant (Kr): 0.01[s-1]
cGMPGMP	r060 IC	HMMIrreversible	cGMPGMP
		reaction rate (J): ((Vmax * cGMP) / (Km + cGMP))[uM.s-1] Km (1/2 max) (Km): 25.0[uM] max reaction rate (Vmax): (Kcat * PDEbg_cGMP)[uM.s-1] user defined (Kcat): 25.0[s-1]
Four1N+GluA1_845AMPAR	r048 PM	MassAction	Four1N+GluA1_845AMPAR
		reaction rate (J): (((Kf * Four1N) * GluA1_845) - (Kr * AMPAR))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): 1.34[molecules.um-2.s-1.uM-2] reverse rate constant (Kr): 0.008[s-1]
PDE2_cGMPGMP+PDE2	r017 IC	MassAction	PDE2_cGMPGMP+PDE2
		reaction rate (J): ((Kf * PDE2_cGMP) - ((Kr * GMP) * PDE2))[uM.s-1] forward rate constant (Kf): 21.5[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1]
PDE2_cAMPAMP+PDE2	r016 IC	MassAction	PDE2_cAMPAMP+PDE2
		reaction rate (J): ((Kf * PDE2_cAMP) - ((Kr * AMP) * PDE2))[uM.s-1] forward rate constant (Kf): 21.0[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1]
PDE2+cAMPPDE2_cAMP	r018 IC	MassAction	PDE2+cAMPPDE2_cAMP
		reaction rate (J): (((Kf * PDE2) * cAMP) - (Kr * PDE2_cAMP))[uM.s-1] forward rate constant (Kf): 3.5[s-1.uM-1] reverse rate constant (Kr): 84.0[s-1]
PDE1+cGMPPDE1_cGMP	r028 IC	MassAction	PDE1+cGMPPDE1_cGMP
		reaction rate (J): (((Kf * PDE1) * cGMP) - (Kr * PDE1_cGMP))[uM.s-1] forward rate constant (Kf): 7.0[s-1.uM-1] reverse rate constant (Kr): 33.6[s-1]
DA_D1R_GabyGby+Ga_GTP+DA_D1R	r005 PM	MassAction	DA_D1R_GabyGby+Ga_GTP+DA_D1R
		reaction rate (J): ((Kf * DA_D1R_Gaby) - (((Kr * Gby) * Ga_GTP) * DA_D1R))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): 20.0[s-1] reverse rate constant (Kr): 0.0[um4.s-1.molecules-2]
PDE1_cGMP+MMPXPDE1_inhibited	r053 IC	MassAction	PDE1_cGMP+MMPXPDE1_inhibited
		reaction rate (J): (((Kf * PDE1_cGMP) * MMPX) - (Kr * PDE1_inhibited))[uM.s-1] forward rate constant (Kf): 1.0[s-1.uM-1] reverse rate constant (Kr): 1.2[s-1]
DARPP32_PiDARPP32	r072 IC	HMMIrreversible	DARPP32_PiDARPP32
		reaction rate (J): ((Vmax * DARPP32_Pi) / (Km + DARPP32_Pi))[uM.s-1] Km (1/2 max) (Km): 0.37[uM] max reaction rate (Vmax): (Kcat * PP2A)[uM.s-1] user defined (Kcat): 6.7[s-1]
D1R_Gaby+DADA_D1R_Gaby	r002 PM	MassAction	D1R_Gaby+DADA_D1R_Gaby
		reaction rate (J): (((Kf * D1R_Gaby) * DA) - (Kr * DA_D1R_Gaby))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): 3.33[s-1.uM-1] reverse rate constant (Kr): 10.0[s-1]
PDE1+cAMPPDE1_cAMP	r026 IC	MassAction	PDE1+cAMPPDE1_cAMP
		reaction rate (J): (((Kf * PDE1) * cAMP) - (Kr * PDE1_cAMP))[uM.s-1] forward rate constant (Kf): 0.36[s-1.uM-1] reverse rate constant (Kr): 18.9[s-1]
PDE1_cAMP+MMPXPDE1_inhibited	r052 IC	MassAction	PDE1_cAMP+MMPXPDE1_inhibited
		reaction rate (J): (((Kf * PDE1_cAMP) * MMPX) - (Kr * PDE1_inhibited))[uM.s-1] forward rate constant (Kf): 1.0[s-1.uM-1] reverse rate constant (Kr): 1.2[s-1]
PDE2+cGMPPDE2_active	r011 IC	MassAction	PDE2+cGMPPDE2_active
		reaction rate (J): (((Kf * PDE2) * cGMP) - (Kr * PDE2_active))[uM.s-1] forward rate constant (Kf): 4.1[s-1.uM-1] reverse rate constant (Kr): 0.9[s-1]
R2C2_cAMP2+cAMPR2C2_cAMP3	r042 IC	MassAction	R2C2_cAMP2+cAMPR2C2_cAMP3
		reaction rate (J): (((Kf * R2C2_cAMP2) * cAMP) - (Kr * R2C2_cAMP3))[uM.s-1] forward rate constant (Kf): 0.27[s-1.uM-1] reverse rate constant (Kr): 0.28[s-1]
BRafBRaf_PKA	r085 IC	HMMIrreversible	BRafBRaf_PKA
		reaction rate (J): ((Vmax * BRaf) / (Km + BRaf))[uM.s-1] Km (1/2 max) (Km): 7.5[uM] max reaction rate (Vmax): (Kcat * PKA)[uM.s-1] user defined (Kcat): 3.0[s-1]
BRaf_PKABRaf	r086 IC	HMMIrreversible	BRaf_PKABRaf
		reaction rate (J): ((Vmax * BRaf_PKA) / (Km + BRaf_PKA))[uM.s-1] Km (1/2 max) (Km): 15.657[uM] max reaction rate (Vmax): (Kcat * PP2A)[uM.s-1] user defined (Kcat): 6.0[s-1]
MEKMEK_Ser	r087 IC	HMMIrreversible	MEKMEK_Ser
		reaction rate (J): ((Vmax * MEK) / (Km + MEK))[uM.s-1] Km (1/2 max) (Km): 0.15909[uM] max reaction rate (Vmax): (Kcat * BRaf_PKA)[uM.s-1] user defined (Kcat): 0.18[s-1]
MEK_SerMEK_active	r088 IC	HMMIrreversible	MEK_SerMEK_active
		reaction rate (J): ((Vmax * MEK_Ser) / (Km + MEK_Ser))[uM.s-1] Km (1/2 max) (Km): 0.15909[uM] max reaction rate (Vmax): (Kcat * BRaf_PKA)[uM.s-1] user defined (Kcat): 0.18[s-1]
ERKERK_Tyr	r091 IC	HMMIrreversible	ERKERK_Tyr
		reaction rate (J): ((Vmax * ERK) / (Km + ERK))[uM.s-1] Km (1/2 max) (Km): 0.046296[uM] max reaction rate (Vmax): (Kcat * MEK_active)[uM.s-1] user defined (Kcat): 0.15[s-1]
MEK_activeMEK_Ser	r089 IC	HMMIrreversible	MEK_activeMEK_Ser
		reaction rate (J): ((Vmax * MEK_active) / (Km + MEK_active))[uM.s-1] Km (1/2 max) (Km): 15.657[uM] max reaction rate (Vmax): (Kcat * PP2A)[uM.s-1] user defined (Kcat): 6.0[s-1]
MEK_SerMEK	r090 IC	HMMIrreversible	MEK_SerMEK
		reaction rate (J): ((Vmax * MEK_Ser) / (Km + MEK_Ser))[uM.s-1] Km (1/2 max) (Km): 15.657[uM] max reaction rate (Vmax): (Kcat * PP2A)[uM.s-1] user defined (Kcat): 6.0[s-1]
ERK_TyrERK_active	r092 IC	HMMIrreversible	ERK_TyrERK_active
		reaction rate (J): ((Vmax * ERK_Tyr) / (Km + ERK_Tyr))[uM.s-1] Km (1/2 max) (Km): 0.046296[uM] max reaction rate (Vmax): (Kcat * MEK_active)[uM.s-1] user defined (Kcat): 0.15[s-1]
ERK_TyrERK	r095 IC	HMMIrreversible	ERK_TyrERK
		reaction rate (J): ((Vmax * ERK_Tyr) / (Km + ERK_Tyr))[uM.s-1] Km (1/2 max) (Km): 9.0[uM] max reaction rate (Vmax): (Kcat * STEP_PKA)[uM.s-1] user defined (Kcat): 0.1[s-1]
ATPcAMP	r025 PM	HMMIrreversible	ATPcAMP
		reaction rate (J): ((Vmax * ATP) / (Km + ATP))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] Km (1/2 max) (Km): 1030.0[uM] max reaction rate (Vmax): (Kcat * ACbg)[molecules.um-2.s-1] user defined (Kcat): 0.9[s-1]
D1R+DADA_D1R	r000 PM	MassAction	D1R+DADA_D1R
		reaction rate (J): (((Kf * D1R) * DA) - (Kr * DA_D1R))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): 1.11[s-1.uM-1] reverse rate constant (Kr): 10.0[s-1]
GluA1_845GluA1	r047 IC	HMMIrreversible	GluA1_845GluA1
		reaction rate (J): ((Vmax * GluA1_845) / (Km + GluA1_845))[uM.s-1] Km (1/2 max) (Km): 0.97145[uM] max reaction rate (Vmax): (Kcat * PP1)[uM.s-1] user defined (Kcat): 0.17[s-1]
AMPARGluA1_dephos	r049 PM	HMMIrreversible	AMPARGluA1_dephos
		reaction rate (J): ((Vmax * AMPAR) / (Km + AMPAR))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] Km (1/2 max) (Km): 121.0[molecules.um-2] max reaction rate (Vmax): (Kcat * PP1)[molecules.um-2.s-1] user defined (Kcat): 0.17[molecules.uM-1.um-2.s-1]
GluA1_dephosGluA1+Four1N	r050 PM	MassAction	GluA1_dephosGluA1+Four1N
		reaction rate (J): ((Kf * GluA1_dephos) - ((Kr * GluA1) * Four1N))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): 8.0E-4[s-1] reverse rate constant (Kr): 0.0[molecules.um-2.s-1.uM-2]
PDE4PDE4_PKA	r075 IC	HMMIrreversible	PDE4PDE4_PKA
		reaction rate (J): ((Vmax * PDE4) / (Km + PDE4))[uM.s-1] Km (1/2 max) (Km): 7.5[uM] max reaction rate (Vmax): (Kcat * PKA)[uM.s-1] user defined (Kcat): 3.0[s-1]
Ga_GTP+AC5AC5_Ga	r007 PM	MassAction	Ga_GTP+AC5AC5_Ga
		reaction rate (J): (((Kf * Ga_GTP) * AC5) - (Kr * AC5_Ga))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): 38.5[um2.s-1.molecules-1] reverse rate constant (Kr): 50.0[s-1]
Ga_GTPGa_GDP	r006 PM	MassAction	Ga_GTPGa_GDP
		reaction rate (J): ((Kf * Ga_GTP) - (Kr * Ga_GDP))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): 10.0[s-1] reverse rate constant (Kr): 0.0[s-1]
PDE4_ERKPDE4_ERK_PKA	r077 IC	HMMIrreversible	PDE4_ERKPDE4_ERK_PKA
		reaction rate (J): ((Vmax * PDE4_ERK) / (Km + PDE4_ERK))[uM.s-1] Km (1/2 max) (Km): 7.5[uM] max reaction rate (Vmax): (Kcat * PKA)[uM.s-1] user defined (Kcat): 0.1[s-1]
PDE4_ERK_PKAPDE4	r078 IC	HMMIrreversible	PDE4_ERK_PKAPDE4
		reaction rate (J): ((Vmax * PDE4_ERK_PKA) / (Km + PDE4_ERK_PKA))[uM.s-1] Km (1/2 max) (Km): 8.0[uM] max reaction rate (Vmax): (Kcat * PP1)[uM.s-1] user defined (Kcat): 1.0[s-1]
PDE4_PKAPDE4_ERK_PKA	r080 IC	HMMIrreversible	PDE4_PKAPDE4_ERK_PKA
		reaction rate (J): ((Vmax * PDE4_PKA) / (Km + PDE4_PKA))[uM.s-1] Km (1/2 max) (Km): 25.641[uM] max reaction rate (Vmax): (Kcat * ERK_active)[uM.s-1] user defined (Kcat): 0.1[s-1]
PDE4_ERKPDE4	r076 IC	HMMIrreversible	PDE4_ERKPDE4
		reaction rate (J): ((Vmax * PDE4_ERK) / (Km + PDE4_ERK))[uM.s-1] Km (1/2 max) (Km): 8.0[uM] max reaction rate (Vmax): (Kcat * PP1)[uM.s-1] user defined (Kcat): 5.0[s-1]
PDE4_PKAPDE4	r079 IC	HMMIrreversible	PDE4_PKAPDE4
		reaction rate (J): ((Vmax * PDE4_PKA) / (Km + PDE4_PKA))[uM.s-1] Km (1/2 max) (Km): 8.0[uM] max reaction rate (Vmax): (Kcat * PP1)[uM.s-1] user defined (Kcat): 5.0[s-1]
cAMPAMP	r083 IC	HMMIrreversible	cAMPAMP
		reaction rate (J): ((Vmax * cAMP) / (Km + cAMP))[uM.s-1] Km (1/2 max) (Km): 1.8[uM] max reaction rate (Vmax): (Kcat * PDE4_PKA)[uM.s-1] user defined (Kcat): 27.0[s-1]
cAMPAMP	r084 IC	HMMIrreversible	cAMPAMP
		reaction rate (J): ((Vmax * cAMP) / (Km + cAMP))[uM.s-1] Km (1/2 max) (Km): 1.8[uM] max reaction rate (Vmax): (Kcat * PDE4_ERK)[uM.s-1] user defined (Kcat): 0.01[s-1]
cAMPAMP	r024 IC	HMMIrreversible	cAMPAMP
		reaction rate (J): ((Vmax * cAMP) / (Km + cAMP))[uM.s-1] Km (1/2 max) (Km): 10.0[uM] max reaction rate (Vmax): (Kcat * PDEbg_cAMP)[uM.s-1] user defined (Kcat): 25.0[s-1]
Bay60+PDE2_cGMPPDE2_inhibited	r056 IC	MassAction	Bay60+PDE2_cGMPPDE2_inhibited
		reaction rate (J): (((Kf * Bay60) * PDE2_cGMP) - (Kr * PDE2_inhibited))[uM.s-1] forward rate constant (Kf): 1.0[s-1.uM-1] reverse rate constant (Kr): 0.01[s-1]
PDE4PDE4_ERK	r074 IC	HMMIrreversible	PDE4PDE4_ERK
		reaction rate (J): ((Vmax * PDE4) / (Km + PDE4))[uM.s-1] Km (1/2 max) (Km): 0.47[uM] max reaction rate (Vmax): (Kcat * ERK_active)[uM.s-1] user defined (Kcat): 10.0[s-1]
cAMPAMP	r081 IC	HMMIrreversible	cAMPAMP
		reaction rate (J): ((Vmax * cAMP) / (Km + cAMP))[uM.s-1] Km (1/2 max) (Km): 1.8[uM] max reaction rate (Vmax): (Kcat * PDE4)[uM.s-1] user defined (Kcat): 10.0[s-1]
cGMP+PDE2PDE2_cGMP	r012 IC	MassAction	cGMP+PDE2PDE2_cGMP
		reaction rate (J): (((Kf * cGMP) * PDE2) - (Kr * PDE2_cGMP))[uM.s-1] forward rate constant (Kf): 10.7[s-1.uM-1] reverse rate constant (Kr): 86.0[s-1]
GluA1GluA1_845	r046 IC	HMMIrreversible	GluA1GluA1_845
		reaction rate (J): ((Vmax * GluA1) / (Km + GluA1))[uM.s-1] Km (1/2 max) (Km): 7.5[uM] max reaction rate (Vmax): (Kcat * PKA)[uM.s-1] user defined (Kcat): 6.0[s-1]
cAMPAMP	r082 IC	HMMIrreversible	cAMPAMP
		reaction rate (J): ((Vmax * cAMP) / (Km + cAMP))[uM.s-1] Km (1/2 max) (Km): 1.8[uM] max reaction rate (Vmax): (Kcat * PDE4_ERK_PKA)[uM.s-1] user defined (Kcat): 8.0[s-1]
PDE2_active+Bay60PDE2_inhibited	r057 IC	MassAction	PDE2_active+Bay60PDE2_inhibited
		reaction rate (J): (((Kf * PDE2_active) * Bay60) - (Kr * PDE2_inhibited))[uM.s-1] forward rate constant (Kf): 1.0[s-1.uM-1] reverse rate constant (Kr): 0.01[s-1]
Bay60+PDE2_cAMPPDE2_inhibited	r055 IC	MassAction	Bay60+PDE2_cAMPPDE2_inhibited
		reaction rate (J): (((Kf * Bay60) * PDE2_cAMP) - (Kr * PDE2_inhibited))[uM.s-1] forward rate constant (Kf): 1.0[s-1.uM-1] reverse rate constant (Kr): 0.01[s-1]
PDE2_active_cGMPGMP+PDE2_active	r015 IC	MassAction	PDE2_active_cGMPGMP+PDE2_active
		reaction rate (J): ((Kf * PDE2_active_cGMP) - ((Kr * GMP) * PDE2_active))[uM.s-1] forward rate constant (Kf): 21.5[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1]
ATPcAMP	r009 PM	HMMIrreversible	ATPcAMP
		reaction rate (J): ((Vmax * ATP) / (Km + ATP))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] Km (1/2 max) (Km): 1030.0[uM] max reaction rate (Vmax): (Kcat * AC5)[molecules.um-2.s-1] user defined (Kcat): 0.2[s-1]
PDE2_active_cAMPAMP+PDE2_active	r014 IC	MassAction	PDE2_active_cAMPAMP+PDE2_active
		reaction rate (J): ((Kf * PDE2_active_cAMP) - ((Kr * AMP) * PDE2_active))[uM.s-1] forward rate constant (Kf): 84.0[s-1] reverse rate constant (Kr): 0.0[s-1.uM-1]
GTPcGMP	r039 IC	HMMIrreversible	GTPcGMP
		reaction rate (J): ((Vmax * GTP) / (Km + GTP))[uM.s-1] Km (1/2 max) (Km): 100.0[uM] max reaction rate (Vmax): (Kcat * sGC_basal)[uM.s-1] user defined (Kcat): 0.18[s-1]
R2C2_cAMP+cAMPR2C2_cAMP2	r041 IC	MassAction	R2C2_cAMP+cAMPR2C2_cAMP2
		reaction rate (J): (((Kf * R2C2_cAMP) * cAMP) - (Kr * R2C2_cAMP2))[uM.s-1] forward rate constant (Kf): 0.035[s-1.uM-1] reverse rate constant (Kr): 0.06[s-1]
R2C_cAMP4R2_cAMP4+PKA	r045 IC	MassAction	R2C_cAMP4R2_cAMP4+PKA
		reaction rate (J): ((Kf * R2C_cAMP4) - ((Kr * R2_cAMP4) * PKA))[uM.s-1] forward rate constant (Kf): 0.05[s-1] reverse rate constant (Kr): 0.085[s-1.uM-1]
PDE2_active+cAMPPDE2_active_cAMP	r013 IC	MassAction	PDE2_active+cAMPPDE2_active_cAMP
		reaction rate (J): (((Kf * PDE2_active) * cAMP) - (Kr * PDE2_active_cAMP))[uM.s-1] forward rate constant (Kf): 14.0[s-1.uM-1] reverse rate constant (Kr): 84.0[s-1]
R2C2_cAMP3+cAMPR2C2_cAMP4	r043 IC	MassAction	R2C2_cAMP3+cAMPR2C2_cAMP4
		reaction rate (J): (((Kf * R2C2_cAMP3) * cAMP) - (Kr * R2C2_cAMP4))[uM.s-1] forward rate constant (Kf): 0.27[s-1.uM-1] reverse rate constant (Kr): 0.28[s-1]
Ga_GDP+GbyGaby	r004 PM	MassAction	Ga_GDP+GbyGaby
		reaction rate (J): (((Kf * Ga_GDP) * Gby) - (Kr * Gaby))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): 100.0[um2.s-1.molecules-1] reverse rate constant (Kr): 0.0[s-1]
DA_D1R+GabyDA_D1R_Gaby	r003 PM	MassAction	DA_D1R+GabyDA_D1R_Gaby
		reaction rate (J): (((Kf * DA_D1R) * Gaby) - (Kr * DA_D1R_Gaby))[molecules.um-2.s-1] inward current density (I): 0.0[pA.um-2] net charge valence (netValence): 1.0[1] forward rate constant (Kf): 0.6[um2.s-1.molecules-1] reverse rate constant (Kr): 0.001[s-1]
cAMP+R2C2R2C2_cAMP	r040 IC	MassAction	cAMP+R2C2R2C2_cAMP
		reaction rate (J): (((Kf * cAMP) * R2C2) - (Kr * R2C2_cAMP))[uM.s-1] forward rate constant (Kf): 0.035[s-1.uM-1] reverse rate constant (Kr): 0.06[s-1]
sGC_inactive+SNAPsGC_active	r098 IC	MassAction	sGC_inactive+SNAPsGC_active
		reaction rate (J): (((Kf * sGC_inactive) * SNAP) - (Kr * sGC_active))[uM.s-1] forward rate constant (Kf): 1.0[s-1.uM-1] reverse rate constant (Kr): 0.25[s-1]
GTPcGMP	r099 IC	HMMIrreversible	GTPcGMP
		reaction rate (J): ((Vmax * GTP) / (Km + GTP))[uM.s-1] Km (1/2 max) (Km): 45.0[uM] max reaction rate (Vmax): (Kcat * sGC_active)[uM.s-1] user defined (Kcat): 7.35[s-1]

Structures See in Dashboard
Name	Type Electrical (Membrane Polarity)
IC	Compartment (+) (-)

EC	Compartment (+) (-)

PM	Membrane N/A

Species See in Dashboard
Name	Structure	BioNetGen Definition
PDE2_cGMP	IC

PDE2_inhibited	IC

Bay60	IC

PDEbg_cGMP	IC

GMP	IC

PDE2_cAMP	IC

GTP	IC

sGC_basal	IC

R2C2_cAMP	IC

R2C2	IC

R2C2_cAMP2	IC

PKA	IC

R2C_cAMP4	IC

R2_cAMP4	IC

R2C2_cAMP4	IC

GluA1_845	IC

Four1N	IC

AMPAR	PM

GluA1_dephos	PM

Ga_GTP	PM

PDE1	IC

D1R	PM

Gaby	PM

GluA1	IC

cAMP	IC

DA_D1R_Gaby	PM

PDE1_cGMP	IC

R2C2_cAMP3	IC

PDE2	IC

cGMP	IC

PDE2_active_cAMP	IC

AMP	IC

PDE2_active_cGMP	IC

Gby	PM

Ga_GDP	PM

D1R_Gaby	PM

DA_D1R	PM

PDEbg_cAMP	IC

ACbg	PM

PDE1_cAMP	IC

DA	EC

DARPP32	IC

DARPP32_Pi	IC

AC5	PM

AC5_Ga	PM

DARPP32_Pi_PP1	IC

PP2A	IC

MMPX	IC

PP1	IC

ERK_active	IC

PDE4_ERK	IC

PDE4	IC

PDE4_PKA	IC

PDE4_ERK_PKA	IC

PDE1_inhibited	IC

ATP	IC

BRaf	IC

BRaf_PKA	IC

MEK_active	IC

MEK_Ser	IC

MEK	IC

ERK_Tyr	IC

ERK	IC

STEP	IC

STEP_PKA	IC

PDE2_active	IC

SNAP	IC

sGC_inactive	IC

sGC_active	IC

Molecules See in Dashboard
Name	Text Annotations	BioNetGen Definition

Observables See in Dashboard
Name	Type Count	BioNetGen Definition

Applications

Applications See in Dashboard
Name	Math Type	Annotation
Application0	Deterministic (ODE) Compartmental

Application - Application0

Specifications(Species) - Application0 See in Dashboard
Species	Initial Condition	Diffusion Constant
PDE2_cGMP	0.0 [uM]	0.0 [um2/s]
PDE2_inhibited	0.0 [uM]	0.0 [um2/s]
Bay60	0.0 [uM]	0.0 [um2/s]
PDEbg_cGMP	0.1 [uM]	0.0 [um2/s]
GMP	0.0 [uM]	0.0 [um2/s]
PDE2_cAMP	0.0 [uM]	0.0 [um2/s]
GTP	500.0 [uM]	0.0 [um2/s]
sGC_basal	0.15 [uM]	0.0 [um2/s]
R2C2_cAMP	0.0 [uM]	0.0 [um2/s]
R2C2	0.5 [uM]	0.0 [um2/s]
R2C2_cAMP2	0.0 [uM]	0.0 [um2/s]
PKA	0.0 [uM]	0.0 [um2/s]
R2C_cAMP4	0.0 [uM]	0.0 [um2/s]
R2_cAMP4	0.0 [uM]	0.0 [um2/s]
R2C2_cAMP4	0.0 [uM]	0.0 [um2/s]
GluA1_845	0.0 [uM]	0.0 [um2/s]
Four1N	0.01 [uM]	0.0 [um2/s]
PDE1	0.5 [uM]	0.0 [um2/s]
GluA1	0.01 [uM]	0.0 [um2/s]
cAMP	0.0 [uM]	0.0 [um2/s]
PDE1_cGMP	0.0 [uM]	0.0 [um2/s]
R2C2_cAMP3	0.0 [uM]	0.0 [um2/s]
PDE2	0.5 [uM]	0.0 [um2/s]
cGMP	0.0 [uM]	0.0 [um2/s]
PDE2_active_cAMP	0.0 [uM]	0.0 [um2/s]
AMP	0.0 [uM]	0.0 [um2/s]
PDE2_active_cGMP	0.0 [uM]	0.0 [um2/s]
PDEbg_cAMP	0.1 [uM]	0.0 [um2/s]
PDE1_cAMP	0.0 [uM]	0.0 [um2/s]
DARPP32	0.5 [uM]	0.0 [um2/s]
DARPP32_Pi	0.0 [uM]	0.0 [um2/s]
DARPP32_Pi_PP1	0.0 [uM]	0.0 [um2/s]
PP2A	0.1 [uM]	0.0 [um2/s]
MMPX	0.0 [uM]	0.0 [um2/s]
PP1	0.11 [uM]	0.0 [um2/s]
ERK_active	0.0 [uM]	0.0 [um2/s]
PDE4_ERK	0.0 [uM]	0.0 [um2/s]
PDE4	0.1 [uM]	0.0 [um2/s]
PDE4_PKA	0.0 [uM]	0.0 [um2/s]
PDE4_ERK_PKA	0.0 [uM]	0.0 [um2/s]
PDE1_inhibited	0.0 [uM]	0.0 [um2/s]
ATP	5000.0 [uM]	0.0 [um2/s]
BRaf	0.18 [uM]	0.0 [um2/s]
BRaf_PKA	0.0 [uM]	0.0 [um2/s]
MEK_active	0.0 [uM]	0.0 [um2/s]
MEK_Ser	0.0 [uM]	0.0 [um2/s]
MEK	0.18 [uM]	0.0 [um2/s]
ERK_Tyr	0.0 [uM]	0.0 [um2/s]
ERK	0.36 [uM]	0.0 [um2/s]
STEP	0.2 [uM]	0.0 [um2/s]
STEP_PKA	0.0 [uM]	0.0 [um2/s]
PDE2_active	0.0 [uM]	0.0 [um2/s]
SNAP	0.0 [uM]	0.0 [um2/s]
sGC_inactive	0.15 [uM]	0.0 [um2/s]
sGC_active	0.0 [uM]	0.0 [um2/s]
DA	0.0 [uM]	0.0 [um2/s]
AMPAR	0.0 [uM]	0.0 [um2/s]
GluA1_dephos	0.0 [uM]	0.0 [um2/s]
Ga_GTP	0.0 [uM]	0.0 [um2/s]
D1R	20.0 [uM]	0.0 [um2/s]
Gaby	20.0 [uM]	0.0 [um2/s]
DA_D1R_Gaby	0.0 [uM]	0.0 [um2/s]
Gby	0.0 [uM]	0.0 [um2/s]
Ga_GDP	0.0 [uM]	0.0 [um2/s]
D1R_Gaby	0.0 [uM]	0.0 [um2/s]
DA_D1R	0.0 [uM]	0.0 [um2/s]
ACbg	15.0 [uM]	0.0 [um2/s]
AC5	55.0 [uM]	0.0 [um2/s]
AC5_Ga	0.0 [uM]	0.0 [um2/s]

Specifications(Reaction) - Application0 See in Dashboard
Name	Reaction Mapping
r097	included
r096	included
r010	included
r093	included
r094	included
r027	included
r044	included
r073	included
r051	included
r070	included
r071	included
r019	included
r054	included
r058	included
r001	included
r029	included
r059	included
r060	included
r048	included
r017	included
r016	included
r018	included
r028	included
r005	included
r053	included
r072	included
r002	included
r026	included
r052	included
r011	included
r042	included
r085	included
r086	included
r087	included
r088	included
r091	included
r089	included
r090	included
r092	included
r095	included
r025	included
r000	included
r047	included
r049	included
r050	included
r075	included
r007	included
r006	included
r077	included
r078	included
r080	included
r076	included
r079	included
r083	included
r084	included
r024	included
r056	included
r074	included
r081	included
r012	included
r046	included
r082	included
r057	included
r055	included
r015	included
r009	included
r014	included
r039	included
r041	included
r045	included
r013	included
r043	included
r004	included
r003	included
r040	included
r098	included
r099	included

Simulations - Application0 See in Dashboard
Name	End Time	Output Options
DA1.0	63000.0 [s]	OutputTimeStep 60.0
DA0.1	63000.0 [s]	OutputTimeStep 60.0
DA0.1 + MMPX	63000.0 [s]	OutputTimeStep 60.0
DA0.1 + BAY607550	63000.0 [s]	OutputTimeStep 60.0
DA0.1 + SNAP	63000.0 [s]	OutputTimeStep 60.0

Events - Application0 See in Dashboard
Name	Trigger Type	Variable Assignment
dopamine	on condition: 61200.0	DA --> 0.1
drug	on condition: 61800.0	MMPX --> 0.0, Bay60 --> 0.0, SNAP --> 0.0

Geometry non-spatial1459406324 See in Dashboard
(Origin: 0.0, 0.0, 0.0; Extent: 10.0, 10.0, 10.0[um])
Dimension	Type	Subdomain	Adjacent Subvolumes	Size	Mapped Compartment
	Compartmental	Compartment			PM

Global Parameters

Global Parameters See in Dashboard
Name	Expression