Dashboard

Name - Negative_feedback_homeostasis

BioModel ID - 176190469

Reaction Diagram

reactionDiagram

Physiology

Reactions See in Dashboard
Reaction Name Structure Kinetics
--> R R_synthesis env GeneralKinetics

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Reaction rate: (k0 * E) [mol.litre-1.s-1]

R --> R_degradation env GeneralKinetics

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Reaction rate: (k2 * R * S) [mol.litre-1.s-1]

Ep --> E E_dephosphorylation env GeneralKinetics

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Reaction rate: (k3 * Ep / (Km3 + Ep)) [mol.litre-1.s-1]

E --> Ep E_phosphorylation env GeneralKinetics

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Reaction rate: (k4 * R * E / (Km4 + E)) [mol.litre-1.s-1]

Structures See in Dashboard
Name Type Electrical (Membrane Polarity)
env Compartment (+)   (-)

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Species See in Dashboard
Name Structure
R env

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S env

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Ep env

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E env

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Molecules See in Dashboard
Name Description
R

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S

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E mod ~P ~U .

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Observables See in Dashboard
Name Type BioNetGen Defination Count
O0_R_tot Molecules R Multimolecular

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O0_S_tot Molecules S Multimolecular

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O0_E_tot Molecules E Multimolecular

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Applications

Applications
Name Math Type Annotation
Deterministic

0 - Deterministic

Specifications(Species) - Deterministic
Species Initial Condition Diffusion Constant
R 0.0 0.0
S 0.0 0.0
Ep (Et - E) 0.0
E (Et * ((2.0 * k3 * J4) / (((k4 * R) - k3) + (J3 * (k4 * R)) + (J4 * k3) + pow((pow((((k4 * R) - k3) + (J3 * (k4 * R)) + (J4 * k3)),2.0) - (4.0 * ((k4 * R) - k3) * k3 * J4)),(1.0 / 2.0))))) 0.0
Specifications(Reaction) - Deterministic
Name Reaction Mapping
R_synthesis included
R_degradation included
E_dephosphorylation included
E_phosphorylation included
Simulations - Deterministic
Name End Time Output Options
Simulation0 1.0 every

Global Parameters

Global Parameters See in Dashboard
Name Expression
k0 1.0

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k2 1.0

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k3 0.5

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J3 0.01

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k4 1.0

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J4 0.01

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Et 1.0

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Km3 (J3 * Et)

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Km4 (J4 * Et)

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