Physiology

Reaction Diagram

reactionDiagram

Cross-References

Annotations

Reactions

Reactions
Name
Structure
Kinetics
noninactiveIP3R inactiveIP3R h_reaction_IP3Rinactivation ERM GeneralKinetics

Structures

Name
Type
Electrical
ERM Membrane Ca_store(+)   C(-)
Ca_store Compartment (+)   (-)
C Compartment (+)   (-)

Species

Name
Structure
BioNetGen Definition
Depiction
inactiveIP3R ERM IP3R(act~inact!-,).
Ca_C C Ca().
noninactiveIP3R ERM IP3R(act~act!-,).
Ca_Ca_store Ca_store Ca().
IP3_C C IP3().

Molecules

Name
BioNetGen Definition
DEPICTION
IP3 IP3()
Ca Ca()
IP3R IP3R(act~inact~act,)

Observables

Name
Structure
Count
BNGL Definition
Sequence Type
DEPICTION
O0_IP3_tot Ca_store Molecules IP3(). Multimolecular
O0_Ca_tot Ca_store Molecules Ca(). Multimolecular
O0_IP3R_tot Ca_store Molecules IP3R(act!?,). Multimolecular

Applications

Name
Properties Math Type

Global Parameters

Name
Expression
KD_act_Ca_IP3R 0.2[uM]
KD_IP3_IP3R 0.1[uM]
IP3R pow((h * IP3_C * Ca_C / (IP3_C + KD_IP3_IP3R) / (Ca_C + KD_act_Ca_IP3R)),3.0)[1]
h (noninactiveIP3R / (noninactiveIP3R + inactiveIP3R))[1]

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